cellular structures

Summary

Summary: Components of a cell.

Top Publications

  1. pmc Advances in high-resolution imaging--techniques for three-dimensional imaging of cellular structures
    Diane S Lidke
    Department of Pathology and Cancer Research and Treatment Center, University of New Mexico, Albuquerque, NM 87131, USA
    J Cell Sci 125:2571-80. 2012
  2. pmc The cell: an image library-CCDB: a curated repository of microscopy data
    David N Orloff
    Center for Research in Biological Systems, Basic Science Building, Room 1000, University of California, San Diego, 9500 Gilman Drive, Department Code 0608, La Jolla, CA 92093 0608, USA
    Nucleic Acids Res 41:D1241-50. 2013
  3. pmc CELDA -- an ontology for the comprehensive representation of cells in complex systems
    Stefanie Seltmann
    Charite Universitatsmedizin Berlin, Berlin Brandenburg Center for Regenerative Therapies BCRT, Berlin, Germany
    BMC Bioinformatics 14:228. 2013
  4. ncbi Investigating cellular structures at the nanoscale with organic fluorophores
    Sebastian van de Linde
    Department of Biotechnology and Biophysics, Biozentrum, Julius Maximilians University Würzburg, Am Hubland, 97074 Wurzburg, Germany
    Chem Biol 20:8-18. 2013
  5. ncbi Predicting subcellular localization of proteins using machine-learned classifiers
    Z Lu
    Department of Computing Science, University of Alberta, Edmonton, AB, Canada, T6G 2E8
    Bioinformatics 20:547-56. 2004
  6. ncbi Bacterial cell division: regulating Z-ring formation
    E J Harry
    Department of Biochemistry, University of Sydney, NSW 2006, Australia
    Mol Microbiol 40:795-803. 2001
  7. ncbi Prediction of protein subcellular locations by support vector machines using compositions of amino acids and amino acid pairs
    Keun Joon Park
    Bioinformatics Center, Institute for Chemical Research, Kyoto University, Uji, Kyoto 611 0011, Japan
    Bioinformatics 19:1656-63. 2003
  8. pmc M1 protein allows Group A streptococcal survival in phagocyte extracellular traps through cathelicidin inhibition
    Xavier Lauth
    Department of Pediatrics, University of California San Diego, La Jolla, Calif 92093 0687, USA
    J Innate Immun 1:202-14. 2009
  9. ncbi A cell-centered database for electron tomographic data
    Maryann E Martone
    National Center for Microscopy and Imaging Research, Center for Research in Biological Structure and Department of Neurosciences, University of California, San Diego, La Jolla, 92093 0608, USA
    J Struct Biol 138:145-55. 2002
  10. ncbi The cell-centered database: a database for multiscale structural and protein localization data from light and electron microscopy
    Maryann E Martone
    Department of Neurosciences, University of California at San Diego, San Diego, CA, USA
    Neuroinformatics 1:379-95. 2003

Detail Information

Publications257 found, 100 shown here

  1. pmc Advances in high-resolution imaging--techniques for three-dimensional imaging of cellular structures
    Diane S Lidke
    Department of Pathology and Cancer Research and Treatment Center, University of New Mexico, Albuquerque, NM 87131, USA
    J Cell Sci 125:2571-80. 2012
    ..below the diffraction limit and EM tomography provides high-resolution three-dimensional (3D) images of cellular structures. The ability to perform both fluorescence and electron microscopy on the same sample (correlative light and ..
  2. pmc The cell: an image library-CCDB: a curated repository of microscopy data
    David N Orloff
    Center for Research in Biological Systems, Basic Science Building, Room 1000, University of California, San Diego, 9500 Gilman Drive, Department Code 0608, La Jolla, CA 92093 0608, USA
    Nucleic Acids Res 41:D1241-50. 2013
    ..Since its public launch on 9 August 2010, it has been designed to serve as not only an archive but also an active site for researchers and educators...
  3. pmc CELDA -- an ontology for the comprehensive representation of cells in complex systems
    Stefanie Seltmann
    Charite Universitatsmedizin Berlin, Berlin Brandenburg Center for Regenerative Therapies BCRT, Berlin, Germany
    BMC Bioinformatics 14:228. 2013
    ..CELDA (Cell: Expression, Localization, Development, Anatomy) is a novel ontology for the association of primary experimental data and derived knowledge to various types of cells of organisms...
  4. ncbi Investigating cellular structures at the nanoscale with organic fluorophores
    Sebastian van de Linde
    Department of Biotechnology and Biophysics, Biozentrum, Julius Maximilians University Würzburg, Am Hubland, 97074 Wurzburg, Germany
    Chem Biol 20:8-18. 2013
    ....
  5. ncbi Predicting subcellular localization of proteins using machine-learned classifiers
    Z Lu
    Department of Computing Science, University of Alberta, Edmonton, AB, Canada, T6G 2E8
    Bioinformatics 20:547-56. 2004
    ..These are the most accurate subcellular predictors across the widest set of organisms ever published. Our predictors are part of the Proteome Analyst web-service...
  6. ncbi Bacterial cell division: regulating Z-ring formation
    E J Harry
    Department of Biochemistry, University of Sydney, NSW 2006, Australia
    Mol Microbiol 40:795-803. 2001
    ....
  7. ncbi Prediction of protein subcellular locations by support vector machines using compositions of amino acids and amino acid pairs
    Keun Joon Park
    Bioinformatics Center, Institute for Chemical Research, Kyoto University, Uji, Kyoto 611 0011, Japan
    Bioinformatics 19:1656-63. 2003
    ..We have developed a method based on support vector machines (SVMs)...
  8. pmc M1 protein allows Group A streptococcal survival in phagocyte extracellular traps through cathelicidin inhibition
    Xavier Lauth
    Department of Pediatrics, University of California San Diego, La Jolla, Calif 92093 0687, USA
    J Innate Immun 1:202-14. 2009
    ..We conclude increased resistance to host cathelicidin and killing within phagocyte extracellular traps contribute to the propensity of M1 GAS strains to produce invasive infections...
  9. ncbi A cell-centered database for electron tomographic data
    Maryann E Martone
    National Center for Microscopy and Imaging Research, Center for Research in Biological Structure and Department of Neurosciences, University of California, San Diego, La Jolla, 92093 0608, USA
    J Struct Biol 138:145-55. 2002
    ..The CCDB is designed to provide a resource for structural biologists and to make tomographic data sets available to the scientific community at large...
  10. ncbi The cell-centered database: a database for multiscale structural and protein localization data from light and electron microscopy
    Maryann E Martone
    Department of Neurosciences, University of California at San Diego, San Diego, CA, USA
    Neuroinformatics 1:379-95. 2003
    ....
  11. ncbi Inferring sub-cellular localization through automated lexical analysis
    Rajesh Nair
    CUBIC, Department of Biochemistry and Molecular Biophysics, Columbia University, 650 West 168th Street BB217, New York, NY 10032, USA
    Bioinformatics 18:S78-86. 2002
    ..With the rapid growth in sequence data, the biochemical characterisation of sequences has been falling behind. Our method may be a useful tool for supplementing functional information already automatically available...
  12. ncbi [Visualizing single fluorophores in live cells]
    T A Nenasheva
    Biofizika 51:454-65. 2006
    ..Methods used for lateral mobility studies of single molecules floating on cell membrane were also described...
  13. pmc An unbiased cell morphology-based screen for new, biologically active small molecules
    Masahiro Tanaka
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, USA
    PLoS Biol 3:e128. 2005
    ..Morphology-based screening of diverse cancer cell types has provided a method for discovering potent new small-molecule probes for cell biological studies and anticancer drug candidates...
  14. ncbi A novel three-dimensional variant of the watershed transform for segmentation of electron density maps
    Niels Volkmann
    The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Struct Biol 138:123-9. 2002
    ..The results indicate that the algorithm is reliable, efficient, accurate, and applicable to a wide variety of biological problems...
  15. ncbi Prediction of protein subcellular locations using fuzzy k-NN method
    Ying Huang
    State Key Laboratory of Intelligent Technology and Systems, Department of Automation, Institute of Bioinformatics, Tsinghua University, Beijing 100084, People s Republic of China
    Bioinformatics 20:21-8. 2004
    ..Protein localization data are a valuable information resource helpful in elucidating protein functions. It is highly desirable to predict a protein's subcellular locations automatically from its sequence...
  16. pmc Organelle DB: a cross-species database of protein localization and function
    Nuwee Wiwatwattana
    Department of Molecular, Cellular, and Developmental Biology and Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109 2216, USA
    Nucleic Acids Res 33:D598-604. 2005
    ..We also welcome new data for inclusion in Organelle DB, which may be freely accessed at http://organelledb.lsi.umich.edu...
  17. pmc Modeling the emergence of multi-protein dynamic structures by principles of self-organization through the use of 3DSpi, a multi-agent-based software
    Hedi Soula
    Laboratoire de Productique et d Informatique des Systèmes Manufacturiers, Institut National des Sciences Appliquees de Lyon, Villeurbanne, France
    BMC Bioinformatics 6:228. 2005
    ..Multi-agent systems (MAS) have been proposed as good candidates to achieve this goal...
  18. pmc The cell centered database project: an update on building community resources for managing and sharing 3D imaging data
    Maryann E Martone
    Department of Neurosciences, University of California at San Diego, San Diego, CA 92093 0608, USA
    J Struct Biol 161:220-31. 2008
    ..Here, we provide an update on the CCDB and how it is used by the scientific community. We also describe our work in developing additional knowledge tools, e.g., ontologies, for annotation and query of electron microscopic data...
  19. ncbi 3D reconstruction of high-resolution STED microscope images
    Annedore Punge
    Department of NanoBiophotonics, Max Planck Institute for Biophysical Chemistry, 37077 Gottingen, Germany
    Microsc Res Tech 71:644-50. 2008
    Tackling biological problems often involves the imaging and localization of cellular structures on the nanometer scale...
  20. ncbi [How to measure structures, or new stereology: III. Stereology and electron microscopy]
    A A Mironov
    Morfologiia 129:72-5. 2006
    ..Additionally, the modified version of the rotator for point counting is demonstrated, which significantly accelerates the morphometric procedure...
  21. ncbi A mercury arc lamp-based multi-color confocal real time imaging system for cellular structure and function
    Kenta Saito
    Nikon imaging center, Research Institute for Electronic Science, Hokkaido University, Sapporo, Hokkaido, Japan
    Cell Struct Funct 33:133-41. 2008
    ..Using this optical system, we demonstrate both the high-speed imaging (up to 100 Hz) of intracellular Ca(2+) propagation, and the multi-color imaging of Ca(2+) and PKC-gamma dynamics in living cells...
  22. ncbi Comparison of intensity based similarity measures for matching genomic structures in microscopic images of living cells
    Sambit Bhattacharya
    Dept of Math and Comput Sci, Fayetteville State Univ, NC 28311, USA
    Conf Proc IEEE Eng Med Biol Soc 1:3057-61. 2006
    ..This makes our approach widely applicable in the study of the dynamics of living cells with time-lapse microscopic imaging...
  23. ncbi Feature selection, matching, and evaluation for subcellular structure tracking
    Quan Wen
    Dept of Comput Sci and Eng, Texas Univ, Arlington, TX 76109, USA
    Conf Proc IEEE Eng Med Biol Soc 1:3013-6. 2006
    ..Our technique was validated on real confocal video data with comparison to traditional feature selection and matching methods...
  24. ncbi A C-terminal region dictates the apical plasma membrane targeting of the human sodium-dependent vitamin C transporter-1 in polarized epithelia
    Veedamali S Subramanian
    Department of Medicine, University of California, Irvine, California 92697, USA
    J Biol Chem 279:27719-28. 2004
    ..Our results provide the first direct resolution of functional hSVCT1 expression at the apical cell surface of polarized epithelia and define an apical targeting signal of relevance to transporters of diverse substrate specificity...
  25. ncbi Proteolysis: anytime, any place, anywhere?
    Jonathon Pines
    Wellcome Trust Cancer Research UK, Gurdon Institute and Department of Zoology, Tennis Court Road, Cambridge CB2 1QN, UK
    Nat Cell Biol 7:731-5. 2005
    ..Controlling where a protein is degraded can enhance the specificity and timing of proteolysis, generate asymmetry and maintain sub-compartments even in the mitotic cell. Here, we discuss this aspect of the UPS...
  26. pmc Dynamic microcompartmentation in synthetic cells
    M Scott Long
    Department of Chemistry, Pennsylvania State University, University Park, PA 16802, USA
    Proc Natl Acad Sci U S A 102:5920-5. 2005
    ..This model cytoplasm can be reversibly converted to a single phase by slight changes in temperature or osmolarity, such that local protein concentrations can be manipulated within the vesicle interior...
  27. ncbi Scanning probe evolution in biology
    J K H Hörber
    Department of Physiology, Wayne State University School of Medicine, 5229 Scott Hall, 540 East Canfield Avenue, Detroit, MI 48201, USA
    Science 302:1002-5. 2003
    ....
  28. ncbi Biological soft materials
    Ian W Hamley
    Department of Chemistry, University of Reading, Reading, Berkshire RG6 6AD, UK
    Angew Chem Int Ed Engl 46:4442-55. 2007
    ....
  29. ncbi Effects of acetone, methanol, or paraformaldehyde on cellular structure, visualized by reflection contrast microscopy and transmission and scanning electron microscopy
    R W Hoetelmans
    Department of Surgery, Leiden University Medical Center, The Netherlands
    Appl Immunohistochem Mol Morphol 9:346-51. 2001
    ..For studies on the intracellular localization of soluble or unknown types of antigen, the authors discourage the use of acetone and methanol as single fixatives...
  30. ncbi The in vitro cytopathology of a porcine and the simian (SA-11) strains of rotavirus
    Juliana Galera Castilho
    Departamento de Microbiologia, Universidade Estadual de Londrina, Londrina, PR, Brasil
    Mem Inst Oswaldo Cruz 99:313-7. 2004
    ..In situ terminal deoxynucleotidyl transferase (Tunel) assay did not show positive result. In conclusion, we demonstrated that both strains of rotavirus induced necrosis as the major degenerative effect...
  31. ncbi Markers for correlated light and electron microscopy
    Gina E Sosinsky
    National Center for Microscopy and Imaging Research and Center for Research in Biological Systems, University of California, San Diego, La Jolla, California 92093, USA
    Methods Cell Biol 79:575-91. 2007
  32. ncbi Structural inheritance in Paramecium: ultrastructural evidence for basal body and associated rootlets polarity transmission through binary fission
    Francine Iftode
    Laboratoire de Biologie Cellulaire 4, UPRESA 8080, Bat 444, Universite Paris XI, 91405 Orsay Cedex, France
    Biol Cell 95:39-51. 2003
    ..These results strongly suggest that basal body and associated rootlets (kinetid) polarity is driven by its immediate environment and provide a basis for the structural heredity property observed by Sonneborn some decades ago...
  33. ncbi Ultrastructure of Spironucleus salmonis n. comb. (formerly Octomitus salmonis sensu Moore 1922, Davis 1926, and Hexamita salmonis sensu Ferguson 1979), with a guide to spironucleus species
    Sarah L Poynton
    Department of Comparative Medicine, Johns Hopkins University School of Medicine, Broadway Research Building, Baltimore, Maryland 21205, USA
    Dis Aquat Organ 60:49-64. 2004
    ..salmonis, S. torosa and S. vortens). We recommend that type descriptions of diplomonads be based on organisms taken directly from the host rather than from in vitro culture in order to reliably include the cytoplasmic organelles...
  34. ncbi Protoreaction of protoplasm
    V V Matveev
    Laboratory of Cell Physiology, Institute of Cytology, Russian Academy of Sciences, Tikhoretsky Ave 4, St Petersburg 194064, Russia
    Cell Mol Biol (Noisy-le-grand) 51:715-23. 2005
    ..In addition, the concept of cell hydrophobicity is introduced. Nasonov's School proposed a concept of physiological standardization that allows comparison of data obtained by different investigators and that will also be described here...
  35. ncbi The histochemistry and cell biology vade mecum: a review of 2005-2006
    Douglas J Taatjes
    Department of Pathology, Microscopy Imaging Center, College of Medicine, University of Vermont, Burlington, VT 05405, USA
    Histochem Cell Biol 126:743-88. 2006
    ..In this spirit, this review will highlight some advancements made in these areas in the past 2 years...
  36. ncbi Single walled carbon nanotubes (SWCNT) affect cell physiology and cell architecture
    Jean Pierre Kaiser
    Materials Biology Interactions Laboratory, Materials Science and Technology Empa, Lerchenfeldstrasse 5, St Gallen CH 9014, Switzerland
    J Mater Sci Mater Med 19:1523-7. 2008
    ..The effect on cell behaviour (cell proliferation, cell activity, cytoskeleton organization, apoptosis and cell adhesion) were dependent on cell type, SWCNT quality (purified or not) and SWCNT concentration...
  37. pmc Teaching cell biology to nonscience majors through forensics, or how to design a killer course
    Laura Arwood
    Department of Biology, Marist College, 3399 North Road, Poughkeepsie, New York 12601, USA
    Cell Biol Educ 3:131-8. 2004
    ..In pre/post testing, students in this course significantly increased their performance on critical thinking assessment tests from 33.3% correct to 45.3% (p =.008, df = 4; n = 24)...
  38. ncbi Electron microscopy in cell biology: integrating structure and function
    Abraham J Koster
    Department of Molecular Cell Biology, Faculty of Biology Institute of Biomembranes, Utrecht, The Netherlands
    Nat Rev Mol Cell Biol . 2003
    ..Recent procedural and technical developments have increasingly improved the power of EM as a cell-biological tool...
  39. ncbi Prostasome-like granules from the PC-3 prostate cancer cell line increase the motility of washed human spermatozoa and adhere to the sperm
    J Wang
    Department of Medical Sciences, Clinical Chemistry, University Hospital, S-751 85, Uppsala, Sweden
    Eur J Obstet Gynecol Reprod Biol 96:88-97. 2001
    ..CONCLUSION: It is concluded that PC-3 prostasomes bear a functional resemblance to seminal prostasomes as regards sperm motility promotion...
  40. ncbi In vivo noninvasive identification of cell composition of intimal lesions: a combined approach with ultrasonography and immunocytochemistry
    M Puato
    Dipartamento di Medicina Clinica e Sperimentale, University of Padua, Via Giustiniani 2, 35128 Padua, Italy
    J Vasc Surg 38:1390-5. 2003
    ..We investigated whether differences in cellular composition of the shoulder region of carotid plaque, a cell-rich, debris-free area, can be revealed with computer-driven analysis of ultrasound scans...
  41. ncbi Use of frozen-hydrated axonemes to assess imaging parameters and resolution limits in cryoelectron tomography
    Bruce F McEwen
    Wadsworth Center, New York State Department of Health, P O Box 509, Empire State Plaza, Albany, NY 12201 0509, USA
    J Struct Biol 138:47-57. 2002
    ..Instrumental and computational strategies to circumvent this limitation are discussed...
  42. ncbi Translational polymorphism as a potential source of plant proteins variety in Arabidopsis thaliana
    Alex V Kochetov
    Institute of Cytology and Genetics, Pr Lavrentieva 10, Novosibirsk 630090, Russia
    Bioinformatics 20:445-7. 2004
    ..Functional significance of such a protein translational polymorphism is still unknown...
  43. ncbi Three-dimensional imaging of biological complexity
    Joachim Frank
    Howard Hughes Medical Institute, Health Research, Incorporated, Albany, NY 12201 0509, USA
    J Struct Biol 138:85-91. 2002
    ..As techniques of cryo-microtomy are perfected, we hope to be able to apply tomography to high-pressure frozen sections of tissue...
  44. ncbi Building the cell: design principles of cellular architecture
    Susanne M Rafelski
    Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California 94158, USA
    Nat Rev Mol Cell Biol 9:593-602. 2008
    ..By examining how these parameters are controlled in specific cell biological examples we can identify a handful of simple design principles that seem to underlie cellular architecture and assembly...
  45. ncbi Three-dimensional localization of ultrasmall immuno-gold labels by HAADF-STEM tomography
    Ulrike Ziese
    Molecular Cell Biology, Utrecht University, 3584 CH Utrecht, The Netherlands
    J Struct Biol 138:58-62. 2002
    ..We conclude that it is possible to combine the high-fidelity structural information of TEM tomograms with the ultrasmall label localization ability of HAADF-STEM tomograms...
  46. pmc Cracking up: symmetry breaking in cellular systems
    Ewa Paluch
    Max Planck Institute of Molecular Cell Biology and Genetics, Dresden 01307, Germany
    J Cell Biol 175:687-92. 2006
    ..A similar tension-induced polarization is observed in actin gels growing around beads, and we propose that a common mechanism governs actin gel rupture in both systems...
  47. ncbi Manipulation of host hepatocytes by the malaria parasite for delivery into liver sinusoids
    Angelika Sturm
    Bernhard Nocht Institute for Tropical Medicine, Bernhard Nocht Strasse 74, 20359 Hamburg, Germany
    Science 313:1287-90. 2006
    ..Thus, the hepatocyte-derived merosomes appear to ensure both the migration of parasites into the bloodstream and their protection from host immunity...
  48. ncbi Functional role of arginine 375 in transmembrane helix 6 of multidrug resistance protein 4 (MRP4/ABCC4)
    Azza A K El-Sheikh
    Department of Pharmacology and Toxicology, Radboud University Nijmegen Medical Centre, Nijmegen Centre for Molecular Life Sciences, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Mol Pharmacol 74:964-71. 2008
    ..A homology model of MRP4 showed that Arg375 and Arg998 face right into the central aqueous pore of MRP4. We conclude that positively charged amino acids in transmembrane helices 6 and 12 contribute to the MRP4 substrate-binding pocket...
  49. ncbi A novel embedment-free immunoelectron microscopy technique reveals association of apoptosis-regulating proteins with subcellular structures
    B Gajkowska
    Laboratory of Cell Ultrastructure, Medical Research Centre, Polish Academy of Sciences, 5 Pawinski Street, 02 106 Warsaw, Poland
    Histochem J 34:441-6. 2002
    ..Application of this technique in combination with EF-EM technique augments our knowledge on the precise identification and relationship of subcellular structures containing Bax, Bid, VDAC-1 and caspase-8...
  50. pmc Itinerant exosomes: emerging roles in cell and tissue polarity
    Aparna Lakkaraju
    Margaret M Dyson Vision Research Institute, Department of Ophthalmology, Weill Medical College of Cornell University, New York, NY 10021, USA
    Trends Cell Biol 18:199-209. 2008
    ..In this review, we discuss new evidence suggesting that exosomes participate in the transport of morphogens and RNA, and thus influence cell polarity and developmental patterning of tissues...
  51. ncbi Honey, we need to talk about the membrane progestin receptors
    Maria Sofia Fernandes
    Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Hospital, London W12 ONN, United Kingdom
    Steroids 73:942-52. 2008
    ..While the reason for these startling opposing results remains unclear, a critical review of existing data may help to shed some light onto the controversial mPRs. Time has come to talk...
  52. ncbi Modelling biological modularity with CellML
    M T Cooling
    Auckland Bioengineering Institute, The University of Auckland, Auckland, New Zealand
    IET Syst Biol 2:73-9. 2008
    ..Finally, the authors discuss the dilemmas associated with modelling protein-to-protein interactions, and the vision for using future CellML enhancements to resolve potential duplications when combining independently developed models...
  53. ncbi Compartmentalized signalling of Ras
    M R Philips
    Department of Medicine, Cell Biology and Pharmacology, NYU School of Medicine, New York, NY, USA
    Biochem Soc Trans 33:657-61. 2005
    ..Thus the signalling output of Ras depends on its subcellular localization...
  54. pmc Morphological and physiological changes induced by high hydrostatic pressure in exponential- and stationary-phase cells of Escherichia coli: relationship with cell death
    Pilar Mañas
    School of Food Biosciences, University of Reading, Whiteknights, Reading RG6 6AP, United Kingdom
    Appl Environ Microbiol 70:1545-54. 2004
    ..Although gross changes were detected in these cellular structures, they were not related to cell death, at least for stationary-phase cells...
  55. ncbi Fluorescence microscopy with super-resolved optical sections
    Alexander Egner
    Max Planck Institute for Biophysical Chemistry, Department of NanoBiophotonics 37077 Göttingen, Germany
    Trends Cell Biol 15:207-15. 2005
    ..Noninvasive axial sections of 80-160 nm thickness deliver more faithful 3D-images of subcellular features, providing a new opportunity to significantly enhance our understanding of cellular structure and function...
  56. ncbi [Muscular dystrophy and dystrophin and its associated proteins]
    E Ozawa
    National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo
    No To Hattatsu 28:102-8. 1996
    ..Duchenne and Becker muscular dystrophies are considered as having compound lesions of these two structures...
  57. pmc Evaluation of technetium-99m decay on Escherichia coli inactivation: effects of physical or chemical agents
    C R Silva
    , Universidade do Estado do Rio de Janeiro, Brazil
    Yale J Biol Med 71:7-14. 1998
    Technetium-99m (99mTc) has been used in nuclear medicine and in biomedical research to label molecular and cellular structures employed as radiotracers...
  58. ncbi Evolution of assisted protein folding: the distribution of the main chaperoning systems within the phylogenetic domain archaea
    Alberto J L Macario
    Wadsworth Center, New York State Department of Health, Division of Molecular Medicine The University at Albany SUNY, Albany, New York 12201 0509, USA
    Front Biosci 9:1318-32. 2004
    ..Also, the data suggest new avenues of research for elucidating the evolution of assisted protein folding and for uncovering roles and interactions not yet described for these molecules...
  59. ncbi Perspectives in the coordinate regulation of cell cycle events in Synechococcus
    Yukio Asato
    University of Massachusetts Dartmouth, N Dartmouth, Massachusetts 02747, USA
    Curr Issues Mol Biol 8:91-5. 2006
    ..coli. In any case, the genes that are involved in the formation of the cellular structures and the genes that control the orderly appearances of the cell cycle events must be coordinated by novel ..
  60. ncbi Characterization of hair follicle antigens targeted by the anti-hair follicle immune response
    Desmond J Tobin
    Department of Biomedical Sciences, University of Bradford, Bradford, England
    J Investig Dermatol Symp Proc 8:176-81. 2003
    ..We are currently applying a more molecular approach (e.g., cDNA library screening) to identify hair follicle antigens truly associated with the onset of the disorder...
  61. pmc Development of a rabbit corneal equivalent using an acellular corneal matrix of a porcine substrate
    Yong Gen Xu
    Department of Ophthalmology, Peking University Third Hospital, Beijing, China
    Mol Vis 14:2180-9. 2008
    ..The tissue engineered corneal epithelium, stroma, and endothelium scaffold are promising concepts in overcoming the current limitations of a cornea replacement with an allograft...
  62. ncbi pCMBS-induced swelling of dogfish (Squalus acanthias) rectal gland cells: role of the Na+,K(+)-ATPase and the cytoskeleton
    A Kleinzeller
    Department of Physiology, University of Pennsylvania, Philadelphia 19104 6085
    Biochim Biophys Acta 1025:21-31. 1990
    ....
  63. ncbi Ras-related proteins in signal transduction and growth control
    F McCormick
    Onyx Pharmaceuticals, Richmond, California 94806, USA
    Mol Reprod Dev 42:500-6. 1995
    ..The possible connection between R-Ras and apoptosis will be discussed...
  64. ncbi New tetrachromic VOF stain (Type III-G.S) for normal and pathological fish tissues
    C Sarasquete
    Instituto de Ciencias Marinas de Andalucia, CSIC, Poligono Rio San Pedro, Apdo Oficial, Puerto Real, Cadiz, Spain
    Eur J Histochem 49:211-27. 2005
    ..Cartilaginous tissues showed a blue or purple (Methyl Blue affinity) staining, and a specific red colour (Acid Fucshin affinity) was evident during calcification or in bone structures (i.e skeleton, fins, gills, teeth)...
  65. ncbi Sedimentation properties of chitosomal chitin synthetase from the wild-type strain and the 'slime' variant of Neurospora crassa
    J P Martinez
    Departamento de Microbiologia, Facultad de Farmacia, Universidad de Valencia, Spain
    Biochim Biophys Acta 990:45-52. 1989
    Marked differences in the pattern of sedimentation of cellular structures were observed after isopycnic centrifugation of crude cell-free preparations from the Neurospora crassa wall-less 'slime' variant and mycelial wild-type strain...
  66. ncbi Identification of glyceraldehyde-3-phosphate dehydrogenase of epithelial cells as a second molecule that binds to Porphyromonas gingivalis fimbriae
    Hakimuddin T Sojar
    Department of Oral Biology, School of Dental Medicine, State University of New York at Buffalo, 213 Foster Hall, 3435 Main Street, Buffalo, NY 14214 3092, USA
    FEMS Immunol Med Microbiol 45:25-30. 2005
    ..gingivalis major fimbriae and, as such, GAPDH likely plays a role in P. gingivalis adherence and colonization of the oral cavity, as well as triggering host cell processes involved in the pathogenesis of P. gingivalis infections...
  67. ncbi Expression of the Wilms' tumor gene WT1 in the murine urogenital system
    J Pelletier
    Center for Cancer Research, Massachusetts Institute of Technology, Cambridge 02139
    Genes Dev 5:1345-56. 1991
    ....
  68. ncbi In vitro cytotoxicity of the organophosphorus pesticide parathion to FG-9307 cells
    H Li
    Department of Marine Biology, Ocean University of Qingdao, 266003, Qingdao, PR China
    Toxicol In Vitro 15:643-7. 2001
    ..With the increase of the parathion concentration, the damage degree of the cellular structures was more serious...
  69. ncbi Sulfotransferase-mediated activation of mutagens studied using heterologous expression systems
    H Glatt
    German Institute of Human Nutrition, Department of Toxicology, Potsdam Rehbrucke
    Chem Biol Interact 109:195-219. 1998
    ..in some molecules leading to electrophilic cations which may form adducts with DNA and other important cellular structures. Since endogenous sulfotransferases do not appear to be expressed in indicator cells of standard ..
  70. pmc Binding of an ankyrin-1 isoform to obscurin suggests a molecular link between the sarcoplasmic reticulum and myofibrils in striated muscles
    Paola Bagnato
    Molecular Medicine Section, Department of Neuroscience, University of Siena, 53100 Siena, Italy
    J Cell Biol 160:245-53. 2003
    ..800 kD that binds to titin and has been proposed to mediate interactions between myofibrils and other cellular structures. The binding sites and the critical aa required in the interaction between ank1...
  71. ncbi Signal transduction networks and the biology of plant cells
    M J Chrispeels
    Department of Biology, University of California San Diego, La Jolla 92093 0116, USA
    Biol Res 32:35-60. 1999
    ..pass between organelles and a single signal transduction pathway usually involves multiple organelles or cellular structures. Here are some examples to illustrate this new paradigm...
  72. pmc Changes in cellular structures revealed by ultra-high resolution retinal imaging in optic neuropathies
    Stacey S Choi
    Department of Ophthalmology and Vision Science, 4860 Y Street, University of California Davis, Sacramento, CA 95817, USA
    Invest Ophthalmol Vis Sci 49:2103-19. 2008
    ..To study the integrity of inner and outer retinal layers in patients with various types of optic neuropathy by using high-resolution imaging modalities...
  73. ncbi Non-classical use of clathrin during bacterial infections
    P Cossart
    Institut Pasteur, Unité des Interactions Bactéries Cellules, Paris, France
    J Microsc 231:524-8. 2008
    ..They also shed light on a new function for clathrin in mammalian cells, i.e. internalization of objects much larger than previously accepted...
  74. ncbi X-ray tomography of Schizosaccharomyces pombe
    Weiwei Gu
    Department of Anatomy University of California, 513 Parnassus San Francisco, CA 94143, USA
    Differentiation 75:529-35. 2007
    ..absorbs approximately an order of magnitude more strongly than water, producing high-contrast images of cellular structures. As cells are examined in the absence of any chemical fixatives, stains, or contrast enhancement reagents, ..
  75. pmc The involvement of lysosomes in myocardial aging and disease
    Alexei Terman
    Division of Geriatric Medicine, Faculty of Health Sciences, Linkoping University, 58185 Linkoping, Sweden
    Curr Cardiol Rev 4:107-15. 2008
    ..The turnover of damaged cellular structures is hindered by an increased lipofuscin loading of the lysosomal compartment...
  76. ncbi Autoimmunity and molecular mimicry in tropical spastic paraparesis/human T-lymphotropic virus-associated myelopathy
    F Garcia-Vallejo
    Laboratorio de Biología Molecular y Patogénesis, Departamento de Ciencias Fisiologicas, Facultad de Ciencias da Saude, Universidad del Valle, Cali, Colombia
    Braz J Med Biol Res 38:241-50. 2005
    ....
  77. ncbi Toxocara canis (Nematoda, Ascarididae): ultrastructure of the rachis and the ovarian wall
    M Bruňanská
    Parasitological Institute, Slovak Academy of Sciences, Kosice
    Folia Parasitol (Praha) 41:149-53. 1994
    ..Multivesicular labyrinth-like formations can also be observed in the epithelial intercellular spaces in the central portion of the T. canis ovary...
  78. ncbi Protein-carboxyl methylation in adrenal medullary cells
    C Gagnon
    Urology Research Laboratory, Royal Victoria Hospital, Faculty of Medicine, McGill University, Montreal, Quebec, Canada
    Cell Mol Neurobiol 8:95-103. 1988
    ..They further suggest that methylation may occur on nascent peptide chains before they are injected into the rough endoplasmic reticulum...
  79. ncbi [Effect of bone marrow graft collection on composition of peripheral blood stem cell grafts from healthy donors after recombinant human granulocyte colony-stimulating factor application in vivo for mobilization]
    Ying Jun Chang
    People s Hospital and Institute of Hematology, Peking University, Bejing 100044, China
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 16:610-3. 2008
    ....
  80. ncbi Human umbilical cord blood-derived stromal cell, a new resource of feeder layer to expand human umbilical cord blood CD34+ cells in vitro
    Lei Gao
    Department of Hematology, Xinqiao Hospital, The Third Military Medical University, Chongqing, People s Republic of China
    Blood Cells Mol Dis 36:322-8. 2006
    ..05). The results indicate that human umbilical cord blood-derived stromal cells may be a suitable feeder layer for expansion of hematopoietic progenitors from hUCB in vitro...
  81. ncbi Extensive esterification of adrenal C19-delta 5-sex steroids to long-chain fatty acids in the ZR-75-1 human breast cancer cell line
    R Poulin
    Medical Research Council Group in Molecular Endocrinology, Laval University Medical Centre, Quebec, Canada
    J Biol Chem 264:9335-43. 1989
    ....
  82. ncbi Lipidomic processes in homeostatic and LPS-modified cell renewal cycle. Role of phosphatidylinositol 3-kinase pathway in biomembrane synthesis and restitution of apical epithelial membrane
    A Slomiany
    Research Center University of Medicine and Dentistry of New Jersey, Newark, NJ 07103, USA
    J Physiol Pharmacol 54:533-51. 2003
    ....
  83. ncbi Cluster analysis of p53 and Ki67 expression, apoptosis, alpha-fetoprotein, and human chorionic gonadotrophin indicates a favorable prognostic subgroup within the embryonal carcinoma germ cell tumor
    Madhu Mazumdar
    Memorial Sloan Kettering Cancer Center, 307 E 63rd St, 3rd Floor, New York, NY 10021, USA
    J Clin Oncol 21:2679-88. 2003
    ..We sought to determine whether simultaneous expression of one or more of these markers could identify clinically relevant subgroups of patients with nonseminomatous GCT (NSGCT)...
  84. ncbi Application of sonication to release DNA from Bacillus cereus for quantitative detection by real-time PCR
    Else Marie Fykse
    Norwegian Defence Research Establishment, Division for Protection and Materiel, PO Box 25, N 2027 Kjeller, Norway
    J Microbiol Methods 55:1-10. 2003
    ..The aim of this study was complete disruption of cellular structures and release of DNA without the need for lysing reagents and time-consuming sample preparation...
  85. ncbi Basal cell carcinoma with tricholemmal (at the lower portion) differentiation within seborrheic keratosis
    Noriyuki Misago
    Division of Dermatology, Department of Internal Medicine, Saga Medical School, Saga, Japan
    J Cutan Pathol 30:196-201. 2003
    ..However, it is generally thought that clear cell basal cell carcinoma is a result of degeneration rather than tricholemmal differentiation...
  86. ncbi Increased expression and purification of soluble iron-regulatory protein 1 from Escherichia coli co-expressing chaperonins GroES and GroEL
    H Carvalho
    Departamento de Ciencias Biologicas, Universidade Federal de Sao Paulo, Diadema, SP, Brasil
    Braz J Med Biol Res 41:270-6. 2008
    ..These results corroborate previous studies, which suggest the use of folding catalysts as a powerful strategy to increase protein solubility when expressing heterologous proteins in E. coli...
  87. ncbi The role of specific IgE and beta-propiolactone in reactions resulting from booster doses of human diploid cell rabies vaccine
    M C Anderson
    Office of Biologics Research and Review, Food and Drug Administration, Bethesda, MD 20892
    J Allergy Clin Immunol 80:861-8. 1987
    ..5:1.(abstract truncated at 250 words)..
  88. ncbi The novel lectin KM+ detects a specific subset of mannosyl-glycoconjugates in the rat cerebellum
    Silvia A Teixeira
    Department of Pharmacology, School of Medicine, University of Campinas, Brazil
    Glycoconj J 20:501-8. 2004
    ..Biotinylated KM+ stained most cellular structures in the adult rat cerebellum, particularly Purkinje cells bodies and the surface of granule cells, but not ..
  89. pmc Infertility with impaired zona pellucida adhesion of spermatozoa from mice lacking TauCstF-64
    Steve Tardif
    Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, Texas 79430, USA
    Biol Reprod 83:464-72. 2010
    Fertilization is a multistep process requiring spermatozoa with unique cellular structures and numerous germ cell-specific molecules that function in the various steps...
  90. ncbi Assessment of the effect of Punica granatum (pomegranata) on the bioavailability of the radiopharmaceutical sodium pertechnetate (99mTc) in Wistar rats
    L F Amorim
    Universidade Federal do Rio Grande do Norte, Centro de Biociencias, Depto de Fisiologia Av Salgado Filho, 3000, Natal, RN 59078 970, Brazil
    Cell Mol Biol (Noisy-le-grand) 49:501-7. 2003
    ..technetium-99m (99mTc) have stimulated the development of labeling techniques for different molecular and cellular structures. It is generally accepted that a variety of factors other than disease can alter the bioavailability of ..
  91. ncbi The Lip lipoprotein from Neisseria gonorrhoeae stimulates cytokine release and NF-kappaB activation in epithelial cells in a Toll-like receptor 2-dependent manner
    Philip L Fisette
    Division of Infectious Diseases, Department of Physiology and Biophysics, Boston University School of Medicine, 650 Albany Street, Boston, MA 02118, USA
    J Biol Chem 278:46252-60. 2003
    ..8/Lip in HEK cells was enhanced upon coexpression of TLR1 but not TLR6. These observations provide evidence that Lip is capable of inducing the release of inflammatory mediators from epithelial cells in a TLR2-dependent manner...
  92. ncbi pH-specific synthetic chemistry and solution studies in the binary system of iron(III) with the alpha-hydroxycarboxylate substrate quinic acid: potential relevance to iron chemistry in plant fluids
    M Menelaou
    Department of Chemical Engineering, Aristotle University of Thessaloniki, Thessaloniki 54124, Greece
    Inorg Chem 48:1844-56. 2009
    ..Iron is an essential metal ion in plant growth and development. Mobilization and further use of that metal by cellular structures in metabolic pathways entails the existence of soluble forms complexed with indigenous organic substrates, ..
  93. ncbi Impact of nano titanium dioxide exposure on cellular structure of Anabaena variabilis and evidence of internalization
    Carla Cherchi
    Department of Civil and Environmental Engineering, Northeastern University, Boston, Massachusetts, USA
    Environ Toxicol Chem 30:861-9. 2011
    The present study investigated the impact of nano titanium dioxide (nTiO(2) ) exposure on the cellular structures of the nitrogen-fixing cyanobacteria Anabaena variabilis...
  94. ncbi Dynamics of actin in cardiac myofibrils and fibroblast stress fibers
    Y Shimada
    Department of Anatomy Cell Biology, School of Medicine, Chiba University, Japan
    Cell Struct Funct 22:59-64. 1997
    ..After incorporation of the fluorescent actin analogue into cellular structures, small areas of labeled structures were photobleached with a laser pulse...
  95. pmc Monoclonal antibody to a triggering structure expressed on rat natural killer cells and adherent lymphokine-activated killer cells
    W H Chambers
    Pittsburgh Cancer Institute, University of Pittsburgh, Pennsylvania 15213
    J Exp Med 169:1373-89. 1989
    To study the cellular structures involved in NK and lymphokine-activated killer (LAK) cell function, we have produced a panel of mAbs that modulate the cytolytic function of a population of cells with LAK activity that derive from large ..
  96. pmc Cellular architecture of Treponema pallidum: novel flagellum, periplasmic cone, and cell envelope as revealed by cryo electron tomography
    Jun Liu
    Department of Pathology and Laboratory Medicine, University of Texas Medical School at Houston, 6431 Fannin, MSB 2 228, Houston, TX 77030, USA
    J Mol Biol 403:546-61. 2010
    ..Three-dimensional (3D) reconstructions from 304 infectious organisms revealed unprecedented cellular structures of this unusual member of the spirochetal family...
  97. ncbi Irradiation of platelet components: inhibition of lymphocyte proliferation assessed by limiting-dilution analysis
    N L Luban
    Children s National Medical Center, and The George Washington University School of Medicine, Washington, DC 20010, USA
    Transfusion 40:348-52. 2000
    ..In the current study, the LDA assay was used to investigate the effect of gamma radiation on the proliferative capacity of T cells in plateletpheresis components...
  98. ncbi Planar cell polarity pathway regulates actin rearrangement, cell shape, motility, and nephrin distribution in podocytes
    Sima Babayeva
    Department of Medicine, Nephrology Research Group, McGill University, Montreal, Quebec, Canada
    Am J Physiol Renal Physiol 300:F549-60. 2011
    ..PCP signals lead to the appearance of highly organized cellular structures that support directional cell movement and oriented cell division...
  99. ncbi Linoleic acid stimulates gluconeogenesis via Ca2+/PLC, cPLA2, and PPAR pathways through GPR40 in primary cultured chicken hepatocytes
    Han Na Suh
    Dept of Veterinary Physiology, Chonnam National University, Gwangju 500 757, Korea
    Am J Physiol Cell Physiol 295:C1518-27. 2008
    Fatty acids serve vital functions as sources of energy, building materials for cellular structures, and modulators of physiological responses...
  100. ncbi Mechanism of carbon tetrachloride-induced hepatotoxicity. Hepatocellular damage by reactive carbon tetrachloride metabolites
    M Boll
    Institute of Toxicology, GSF National Research Center for Environment and Health, , Neuherberg, Germany
    Z Naturforsch C 56:649-59. 2001
    ..The former process may result in adduct formation and, ultimately, cancer initiation, whereas the latter results in loss of calcium homeostasis and, ultimately, apoptosis and cell death...
  101. ncbi GFP-tagging of cell components reveals the dynamics of subcellular re-organization in response to infection of Arabidopsis by oomycete pathogens
    Daigo Takemoto
    Plant Cell Biology Group, Research School of Biological Sciences, Australian National University, PO Box 475 Canberra, ACT 2601, Australia
    Plant J 33:775-92. 2003
    ..This result indicates that the induction of cytoplasmic aggregation in Arabidopsis epidermal cells was neither suppressed by the virulent strain of Peronospora, nor effective in stopping infection...

Research Grants69

  1. Iron-mediated vascular disease in sickle cell disease.
    John C Wood; Fiscal Year: 2010
    ..This proposal represents an essential first step in the design of a subsequent clinical trial to improve vascular function in SCD patients. ..
  2. MECHANISMS OF MILK LIPID SECRETION
    JAMES LEWIS MCMANAMAN; Fiscal Year: 2013
    ..These cellular structures are the primary storage depots for triglycerides in liver, adipose and muscle cells;and the source of ..
  3. Roles of RhoA/Rho-kinase Signaling in Cavernous Neurons Following Axonal Injury
    TRINITY JUDE BIVALACQUA; Fiscal Year: 2013
    ..I hope to one day mentor other young surgeon/scientist and provide them with the means and opportunity that my department and K08 funding will afford me. ..
  4. Identifying Key Structural Elements in the Activation of the Arp2/3 Complex
    Patricia A Khuu; Fiscal Year: 2013
    ..Arp2/3 is also involved in metastasis as it is required in the formation of cellular structures such as lamellipodia of migrating cells and invadopodia of cancers cells [5, 6].
  5. Structure and function of Helicobacter pylori VacA
    Timothy L Cover; Fiscal Year: 2013
    ..abstract_text> ..
  6. Role of dyskerin in oral epithelial homeostasis
    Faizan Alawi; Fiscal Year: 2013
    ..mitosis, we have shown that dyskerin expression peaks during mitosis, the protein localizes to distinct sub-cellular structures in mitotic oral keratinocytes, and acute loss of dyskerin function triggers G2/M arrest and leads to the ..
  7. Immune response to Pneumocystis and bone marrow failure
    Nicole Meissner; Fiscal Year: 2013
    ..Understanding how the immune system supports hematopoiesis is needed to develop strategies for the prevention and treatment of pancytopenia in AIDS patients. ..
  8. DEVELOPMENT OF MAMMALIAN OOCYTE-GRANULOSA CELL COMPLEX
    John J Eppig; Fiscal Year: 2012
    ..Resolution of these mechanisms of intercellular signaling will lead to novel clinical solutions to female infertility. ..
  9. Fluorescent Copper Probes for Intracellular Imaging
    Christoph J Fahrni; Fiscal Year: 2013
    ..approach, thus enabling direct correlative light and X-ray fluorescence microscopy of copper and associated cellular structures. Both imaging techniques will be applied to elucidate the role of the Golgi apparatus in copper ..
  10. Inhibition of Reflux-Induced Esophageal Adenocarcinoma by Proanthocyanidins
    Laura A Kresty; Fiscal Year: 2013
    ..frequency-domain optical coherence tomography (FDOCT), to detect early changes in nuclear morphology or sub-cellular structures linked with the development of preneoplasia, biomarker modulation and potentially to detect early ..
  11. Novel approaches to evaluate carbon nanotube health impacts
    KENT ED PINKERTON; Fiscal Year: 2010
    ..surface imperfections, dangling bonds, surface area, reactive functional groups, and size) with vital cellular structures. Our research plan will implement a number of novel approaches for material synthesis and aerosolization, ..
  12. 3C Protease Polyubiquitylation as a Picornavirus Replication Success Determinant
    THOMAS GLEN LAWSON; Fiscal Year: 2012
    ..This is likely in turn to result in the identification of new strategies for treating diseases caused by picornavirus infections. ..
  13. The Role of Caveolins in Lung Inflammation
    CHRISTINA MARIA PABELICK; Fiscal Year: 2013
    ..In this regard, the potential role of cellular structures called caveolae and their constituent caveolin proteins in regulation of airway contractility is an ..
  14. Structure-function studies of alpha- and flaviviruses
    Richard J Kuhn; Fiscal Year: 2010
    ..Electron tomography and immuno-electron microscopy will also be employed as a means to image sub-cellular structures induced and/or utilized during virus infection...
  15. Actin dynamics and regulation of epithelial barrier in intestinal inflammation
    ANDREI IVANOVICH IVANOV; Fiscal Year: 2013
    ..The integrity of the epithelial barrier is regulated by cellular structures known as tight junctions (TJs) and adherens junctions (AJs)...
  16. Development of a 3D cell culture model of the glomerular filtration barrier
    LESLIE BRUGGEMAN; Fiscal Year: 2009
    ..will develop and characterize this 3D model, and will test requirements for the formation of mature cellular structures: foot processes, slit diaphragms, and fenestrae...
  17. Cell Analytics for Viability Experiments (CAVE (TM))
    Melanie M Tomczak; Fiscal Year: 2013
    ..We plan to market the software through our tie ups with microscopy vendors, UC drug discovery center and by directly providing customized services. ..
  18. 3-D optical imaging of the in vivo organ of Corti motion at a sub-nanometer scale
    Alfred L Nuttall; Fiscal Year: 2013
    ..tissue and is the theoretical basis of microscopes that are commercially available to image the lens and cellular structures of the human eye...
  19. Transgenic tools for Gal4 regulated gene expression in zebrafish
    Michael Parsons; Fiscal Year: 2012
    ..Versatile Gal4-based methods allow researchers to visualize subsets of cells or sub-cellular structures with fluorescent markers, to monitor processes that underlie organ formation real-time, to asses protein ..
  20. Actin-Based Motility of a Bacterial Pathogen
    Julie A Theriot; Fiscal Year: 2013
    ....
  21. Human Cardiomyopathy and HSP60
    Anne A Knowlton; Fiscal Year: 2012
    ..progression through cell death mediated by extracellular HSP60 and through abnormal trafficking of HSP60 to cellular structures. In this competing renewal, we propose to extend our studies and investigate the trafficking of HSP60 in ..
  22. STRUCTURAL ANALYSIS OF GAP JUNCTION TRAFFICKING
    Gina E Sosinsky; Fiscal Year: 2013
    ..These form discrete and recognizable cellular structures during quiescent (non-mitotic) phases...
  23. IDENTIFYING GERMLINE GENES AS TARGETS FOR THERAPEUTIC INTERVENTION IN CANCER
    Mary Lou King; Fiscal Year: 2013
    ..Our research will discover novel candidates for the development of new anti-cancer drugs. ..
  24. The Role of Tdrd7 in Mammalian Lens Development
    Richard L Maas; Fiscal Year: 2013
    ..These studies will increase our understanding of lens development, and provide new information on post-transcriptional regulatory mechanisms in oculogenesis. ..
  25. Development of the Gustatory Solitary Nucleus
    Robert M Bradley; Fiscal Year: 2013
    ..It is therefore important to characterize factors controlling normal development of rNST to understand how maternal diet, alcohol consumption and drugs can influence neural development and synaptogenesis of the rNST. ..
  26. Super-resolution studies of the entry mechanisms of influenza viruses
    Xiaowei Zhuang; Fiscal Year: 2013
    ..STORM), which provides near-molecular-scale resolution with high molecular specificity for imaging cellular structures. In this project, we will further improve the resolution of STORM and apply this novel technique to ..
  27. The Role of Autophagy in the Pathogenesis of interstitial Lung Disease
    TIMOTHY EDWARD WEAVER; Fiscal Year: 2013
    ..These studies will provide new diagnostic tools, new therapeutic targets and appropriate animal models to facilitate identification of pathogenetic pathways and development of novel treatment paradigms for ILD. ..
  28. VEGF regulation of neurogenesis
    DIANE CATHERINE DARLAND; Fiscal Year: 2011
    ..The current proposal will address specifically a role for VEGF in regulating the survival, proliferation, and differentiation of neural stem cells in the context of the developing vasculature. ..
  29. Developmental Dynamics of Ciliated Epithelia
    BRIAN JOSEPH MITCHELL; Fiscal Year: 2013
    ..The goal of this project is to understand how any organ develops the cellular structures called cilia that are required to generate this flow...
  30. Structural studies of tight junction proteins
    John M Flanagan; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Tight junctions (TJs) are essential cellular structures that form the selective paracellular barriers in endothelial and epithelial cells, including the blood-brain, and blood-retinal barriers, lung ..
  31. Proton-Coupling Strategies in Alkaliphilic Bacillus
    Terry Ann Krulwich; Fiscal Year: 2013
    ....
  32. The Production and Dissipation of Energy in the Hair Bundle of the Inner Ear
    ADRIA CLAIRE LEBOEUF; Fiscal Year: 2010
    ..further, how can such a movement be accomplished continuously for more than 80 years without harming the cellular structures and causing hearing loss? The present studies pursue two distinct lines of research addressing these ..
  33. Ophthalmic Imaging Using Adaptive Optics and OCT
    John S Werner; Fiscal Year: 2012
    ..The engineering goals are directed toward increasing contrast of cellular structures by use of autofluoresence, birefringence, the incorporation of "extreme AO" techniques, and functional ..
  34. International Conference on the Cell and Molecular Biology of Chlamydomonas
    David R Mitchell; Fiscal Year: 2013
    ..biochemistry, biophysics, structural biology, and genomics to learn about basic, evolutionarily conserved cellular structures and processes...
  35. The mechanism of action of a NudC domain small heat shock protein
    Nicholas J Kaplinsky; Fiscal Year: 2010
    ..At high temperatures BOB1 is incorporated into heat shock granules (HSGs), stress-induced sub-cellular structures whose function and behavior are poorly characterized...
  36. MECHANISMS OF BARTONELLA VIRULENCE IN AIDS PATIENTS
    Jane E Koehler; Fiscal Year: 2012
    ..We are investigating how this bacterium is able to cause long term infections in the blood of humans, sometimes for years, so that infection can be prevented. ..
  37. T cell Inhibitory receptor blockade in chronic blood-stage malaria
    John T Harty; Fiscal Year: 2013
    ..chabaudi chabaudi blood-stage infection. Aim 4. Determine if and how inhibitory receptor blockade during chronic blood-stage infection impacts cross- species and cross-stage-specific protective immunity to reinfection. ..
  38. Cell cycle regulation of Golgi membrane dynamics
    Joachim Seemann; Fiscal Year: 2013
    ..Defects in mitosis can lead to the missegregation and loss of vital cellular structures such as chromosomes and organelles...
  39. Extracellular Matrix and Outflow Resistance
    Kate E Keller; Fiscal Year: 2013
    ..Here, we propose a working model whereby ADAMTS4 is activated at specialized cellular structures, then cleaves its target molecules and is internalized into the cell in endosomes...
  40. MOLECULAR MECHANISMS OF POLYOMA INDUCED TRANSFORMATION
    Thomas M Roberts; Fiscal Year: 2013
    ..Each of these aims has considerable potential to facilitate therapy for a number of important human tumor types. ..
  41. High Resolution 3D Optics Coherence Phase Microscopy
    Johannes F de Boer; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Three-dimensional imaging of cells and sub cellular structures has enormous potential in studies on cell physiology and medicine, since it enables the observation of cell behavior in a variety of ..
  42. AXONAL PATHWAY SELECTION IN THE ZEBRAFISH EMBRYO
    Michael Granato; Fiscal Year: 2013
    ..cones and postsynaptic development might be transmitted through a signaling pathway known to position cellular structures or processes at defined positions within the tissue plane...
  43. A Clonable High-Density for 3-D Electron Microscopy of Cellular Structures
    Andreas Hoenger; Fiscal Year: 2010
    ..tag would revolutionize the utility of cellular tomography because the 3D position of proteins in complex cellular structures could be determined by tomography at nanometer resolution...
  44. Center for Nanobiology and Predictive Toxicology
    ANDRE ELIAS NEL; Fiscal Year: 2013
    ..physical and Chemical properties of carefully selected ENM libraries relate to interactions with cells and cellular structures, including how these bio-physicochemical interactions at the nano-bio interface may lead to pulmonary ..
  45. Ultra-Precise Laser Surgery to study Cell Biomechanics
    Yukiko Yamashita; Fiscal Year: 2013
    ..The ability to selectively ablate or cut cellular structures is central to this proposal...
  46. Amnis ImageStream Analyzer
    Anne I Sperling; Fiscal Year: 2010
    ..at its core understanding, requires the ability to measure many characteristics of cells and sub- cellular structures for the purpose of understanding the function of proteins within a cell, cell subtypes within a population, ..
  47. ACTIONS OF CYCLIC GMP IN SMOOTH MUSCLE
    Thomas Lincoln; Fiscal Year: 1999
    ..cGMP-regulated protein phosphorylation to occur in VSM cells, the cGMP kinase must be localized to cellular structures (organelles) that contain these substrate proteins...
  48. MIT LASER BIOMEDICAL RESEARCH CENTER
    RAMACHANDRA RAO DASARI; Fiscal Year: 2011
    ..New technology on quantitative interferometric microscopy will be exploited for measuring cellular structures at the nanometer level...
  49. Role of Wnts in Cardiac Repair
    Arjun Deb; Fiscal Year: 2013
    ..Identification of cell components secreting Wnts, target cells responding to Wnts, and physiological benefits of interrupting Wnt1 signaling in the infarcted heart can potentially lead to novel therapies for myocardial infarction. ..
  50. Quantitative models for controlling collective cell fate selection in stem cells
    Matthew Thomson; Fiscal Year: 2013
    ..However, our ability to coax stem cells to form complex multi- cellular structures is currently limited by deep conceptual and technical challenges...
  51. Organization of Sarcoplasmic Reticulum in Skeletal Muscle
    Robert J Bloch; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE. For skeletal muscle to function properly, it must organize and stabilize the cellular structures that store and release calcium ions...
  52. Structure and Function of Neurotransmitter Transporters
    Harel Weinstein; Fiscal Year: 2013
    ....
  53. Bacterial cytoskeletal structures and dynamics at single molecule level
    Ji Yu; Fiscal Year: 2013
    ..Although being an active area of research, mechanistic understandings of these cellular structures, especially their general impact on the dynamics of cellular chemistry is under-explored...
  54. A MULTI-SCALE APPROACH TO CELL STRUCTURE &FUNCTION
    Andreas Hoenger; Fiscal Year: 2013
    ..This way we provide a direct link between cellular structures and macromolecular detail and atomic-scale interpretation...
  55. Dual-Beam Scanning Electron Microscope for New York Structural Biology Center
    David L Stokes; Fiscal Year: 2010
    ..four neurobiology projects, two projects addressing pathogenesis of bacteria and HIV, and studies of cellular structures involved in autophagy, endocytosis, LDL processing and cell-cell adhesion...
  56. Structure and regulation of synaptic architecture
    AVITAL ADAH RODAL; Fiscal Year: 2012
    ..ultrastructures of presynaptic endosomes at the NMJ, and to determine their relationship to other cellular structures in wildtype and mutant animals...
  57. Mini-Chromosome and Fluorescent Proteins for Expression of Protein Complexes
    RONALD GODISKA; Fiscal Year: 2012
    ..It will also facilitate identification of binding partners and improved imaging of cellular structures. PUBLIC HEALTH RELEVANCE: A large number of proteins within cells form unique multi-subunit complexes, ..
  58. Semi-volatile PCBs: Sources, Exposures, Toxicities
    Larry W Robertson; Fiscal Year: 2013
    ..and/or initiate oxidative events that alter the intracellular redox environment, thereby compromising cellular structures and functions...
  59. Comparative molecular physiology of mammalian formins
    Henry N Higgs; Fiscal Year: 2012
    ..this proposal, I will use a combined biochemical/cellular approach to address assembly of formin-mediated cellular structures, using INF2 and FRL2 as models...
  60. A confocal microscope
    Nilgun E Tumer; Fiscal Year: 2010
    ..LSM 710 include excitation and detection of a wider range of fluorescent probes for multicolor imaging of cellular structures and proteins, fluorescence resonance energy transfer (FRET) for studies of protein-protein interactions and ..
  61. BIOGENESIS OF HYDROGENOSOMES OF A TRICHOMONAD PARASITE
    PATRICIA JEAN JOHNSON; Fiscal Year: 2013
    ..composition of the hydrogenosome and phylogenetic analyses of lits components should help clarify how novel cellular structures and functions were acquired in early eukaryotes and assist in understanding how energy-generating organeUes ..
  62. Water-Window Soft X-Ray Microscope for Small Laboratories
    STEPHEN HORNE; Fiscal Year: 2010
    ..DESCRIPTION (provided by applicant): Soft x-ray microscopy shows enormous promise as a technique for imaging cellular structures at resolutions well beyond what can be achieved in optical microscopes, and with much simpler sample ..
  63. IL-4 Signaling Pathway Regulation of Sjogren's Syndrome
    AMMON PECK; Fiscal Year: 2004
    ..Identification of this effector mechanism could be important to the long-term goal of developing targeted preventive or early intervention strategies. ..
  64. OXIDATION OF MACROMOLECULES IN SPINAL CORD INJURY
    Danxia Liu; Fiscal Year: 2001
    ..This will directly test whether free radicals damage neurons by inducing oxidation of major cell components and will provide strategies for therapy. ..
  65. CHROMOSOME STRUCTURES AND MEIOTIC MECHANISMS
    MARJORIE MAGUIRE; Fiscal Year: 1990
    ..Projects investigate, from several avenues of approach, the nature of cellular structures and processes involved in homologous chromosome pairing, genetic recombination, crossover interference, the ..
  66. Innate Immune Receptors in Host Responses to Neisseria
    ROBIN INGALLS; Fiscal Year: 2009
    ..abstract_text> ..
  67. AUTOANTIBODIES TO CELLULAR MATRIX ANTIGENS IN CFS
    ENG TAN; Fiscal Year: 2000
    ..b>Cellular structures (nuclear envelope, vimentin-containing intermediate filaments and a nuclear matrix particle visualized in ..
  68. ACTIVE SITES OF CREATINE KINASE FROM HEART AND MUSCLE
    GEORGE KENYON; Fiscal Year: 1999
    ..Within the human cell, two cytosolic and two mitochondrial isoenzymes interact with different cellular structures, and evidence suggests that this intracellular localization has profound functional consequences for ..
  69. CELLULAR CONCOMITANTS OF VINCRISTINE RESISTANCE
    JUNE BIEDLER; Fiscal Year: 1992
    ..In situ hybridization and cytogenetic methods with P-glycoprotein, sorcin, and N-myc probes will be used to being this study. Identification of parameters related to resistance development in the drug-treated patient is a long term goal...