Genomes and Genes
Summary: Large, phagocytic mononuclear leukocytes produced in the vertebrate BONE MARROW and released into the BLOOD; contain a large, oval or somewhat indented nucleus surrounded by voluminous cytoplasm and numerous organelles.
Publications210 found, 100 shown here
- Development of monocytes, macrophages, and dendritic cellsFrederic Geissmann
Centre for Molecular and Cellular Biology of Inflammation, Division of Immunology, Infection, and Inflammatory Diseases, King s College London, Great Maze Pond, London SE1 1UL, UK
Science 327:656-61. 2010b>Monocytes and macrophages are critical effectors and regulators of inflammation and the innate immune response, the immediate arm of the immune system...
- Genetics and beyond--the transcriptome of human monocytes and disease susceptibilityTanja Zeller
Medizinische Klinik und Poliklinik, Johannes Gutenberg Universitat Mainz, Mainz, Germany
PLoS ONE 5:e10693. 2010....
- Activated monocytes in peritumoral stroma of hepatocellular carcinoma promote expansion of memory T helper 17 cellsDong Ming Kuang
State Key Laboratory of Oncology in Southern China, Cancer Center, Guangzhou, P R China
Hepatology 51:154-64. 2010..Most peritumoral CD68(+) cells exhibited an activated phenotype. Accordingly, tumor-activated monocytes were significantly superior to the suppressive tumor macrophages in inducing expansion of Th17 cells from ..
- The chemokine system in diverse forms of macrophage activation and polarizationAlberto Mantovani
Centro di Eccellenza per l Innovazione Diagnostica e Terapeutica IDET, Institute of General Pathology, University of Milan, I 20133 Milan, Italy Istituto di Ricerche Farmacologiche Mario Negri, I 20157 Milan, Italy
Trends Immunol 25:677-86. 2004....
- SIVSM/HIV-2 Vpx proteins promote retroviral escape from a proteasome-dependent restriction pathway present in human dendritic cellsCaroline Goujon
LaboRetro, INSERM U758, Ecole Normale Superieure de Lyon, IFR 128 Biosciences Lyon Gerland, Lyon Biopole, France
Retrovirology 4:2. 2007..However, since the requirement for Vpx is specific for DCs and not for other non-dividing cell types, this suggests that Vpx may play a role other than nuclear import...
- The CD14+ CD16+ blood monocytes: their role in infection and inflammationLoems Ziegler-Heitbrock
Department of Infection, Immunity and Inflammation, University of Leicester, Medical Sciences Building, University Road, Leicester, UK
J Leukoc Biol 81:584-92. 2007Blood monocyte subpopulations have been defined in man initially, and the two major types of monocytes are the CD14++ CD16- and the CD14+ CD16+ monocytes...
- The identification of markers of macrophage differentiation in PMA-stimulated THP-1 cells and monocyte-derived macrophagesMarc Daigneault
Department of Infection and Immunity, Medical School, University of Sheffield, Sheffield, United Kingdom
PLoS ONE 5:e8668. 2010..cell line after various protocols of differentiation utilising VD(3) and PMA in comparison to primary human monocytes or monocyte-derived macrophages (MDM)...
- Human CD14dim monocytes patrol and sense nucleic acids and viruses via TLR7 and TLR8 receptorsJerome Cros
U838 INSERM, Universite Paris Descartes, Paris, France
Immunity 33:375-86. 2010b>Monocytes are effectors of the inflammatory response to microbes...
- Nomenclature of monocytes and dendritic cells in bloodLoems Ziegler-Heitbrock
Helmholtz Zentrum Munchen, Gauting, Germany
Blood 116:e74-80. 2010b>Monocytes and cells of the dendritic cell lineage circulate in blood and eventually migrate into tissue where they further mature and serve various functions, most notably in immune defense...
- Microbial stimulation fully differentiates monocytes to DC-SIGN/CD209(+) dendritic cells for immune T cell areasCheolho Cheong
Chris Browne Center for Immunology and Immune Diseases, The Rockefeller University, New York, NY 10065, USA
Cell 143:416-29. 2010..critical antigen-presenting cells for immune control, normally derive from bone marrow precursors distinct from monocytes. It is not yet established if the large reservoir of monocytes can develop into cells with critical features of ..
- Apoptosis-associated speck-like protein (ASC) controls Legionella pneumophila infection in human monocytesDalia H Abdelaziz
Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Center for Microbial Interface Biology and the Department of Internal Medicine, Ohio State University, Columbus, Ohio 43210, USA
J Biol Chem 286:3203-8. 2011..pneumophila to cause pneumonia is determined by its capability to evade the immune system and grow within human monocytes and their derived macrophages...
- Monocyte chemoattractant protein-1 (MCP-1): an overviewSatish L Deshmane
Department of Neuroscience, Temple University School of Medicine, Philadelphia, PA 19140, USA
J Interferon Cytokine Res 29:313-26. 2009..Chemokines play a major role in selectively recruiting monocytes, neutrophils, and lymphocytes, as well as in inducing chemotaxis through the activation of G-protein-coupled ..
- Altered redox state of monocytes from cryopyrin-associated periodic syndromes causes accelerated IL-1beta secretionSara Tassi
Cell Biology Unit, National Cancer Research Institute, 16132 Genoa, Italy
Proc Natl Acad Sci U S A 107:9789-94. 2010In healthy monocytes, Toll-like receptor (TLR) engagement induces production of reactive oxygen species (ROS), followed by an antioxidant response involved in IL-1beta processing and secretion...
- A cellular restriction dictates the permissivity of nondividing monocytes/macrophages to lentivirus and gammaretrovirus infectionRajnish Kaushik
Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
Cell Host Microbe 6:68-80. 2009..We further demonstrate that this restriction prevents transduction of quiescent monocytes by HIV-1...
- Interaction of Vpx and apolipoprotein B mRNA-editing catalytic polypeptide 3 family member A (APOBEC3A) correlates with efficient lentivirus infection of monocytesAndre Berger
Division of Medical Biotechnology, Paul Ehrlich Institut, 63225 Langen, Germany
J Biol Chem 285:12248-54. 2010..HIV-1, which does not encode Vpx, is not able to infect human monocytes, but Vpx enables infection with HIV-1. The underlying mechanism is not completely understood...
- Migrating monocytes recruited to the spleen play an important role in control of blood stage malariaAnne Marit Sponaas
Division of Parasitology, Medical Research Council MRC National Institute for Medical Research, London, UK
Blood 114:5522-31. 2009..During Plasmodium chabaudi infection in mice, a population of CD11b(high)Ly6C(+) monocytes are generated in bone marrow, most of which depend on the chemokine receptor CCR2 for migration from bone marrow ..
- Differential requirement for the activation of the inflammasome for processing and release of IL-1beta in monocytes and macrophagesMihai G Netea
Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, USA
Blood 113:2324-35. 2009..Here we demonstrate that human blood monocytes release processed IL-1beta after a one-time stimulation with either TLR2 or TLR4 ligands, resulting from ..
- Circulating monocytes from systemic sclerosis patients with interstitial lung disease show an enhanced profibrotic phenotypeSusan K Mathai
Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA
Lab Invest 90:812-23. 2010Profibrotic cells derived from circulating CD14+ monocytes include fibrocytes and alternatively activated macrophages...
- CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasisBin Zhi Qian
Department of Developmental and Molecular Biology, Center for the Study of Reproductive Biology and Women s Health, Albert Einstein College of Medicine, New York, New York 10461, USA
Nature 475:222-5. 2011..Here we define the origin of these macrophages by showing that Gr1-positive inflammatory monocytes are preferentially recruited to pulmonary metastases but not to primary mammary tumours in mice...
- Heat shock protein 90 and heat shock protein 70 are components of dengue virus receptor complex in human cellsJorge Reyes-Del Valle
Departamento de Patologia Experimental, Centro de Investigacion y de Estudios Avanzados del IPN, Av I P N 2508, Col San Pedro Zacatenco, Mexico City D F, C P 07360, Mexico
J Virol 79:4557-67. 2005..Based on the ability of HSP90 (84 kDa) to interact with HSP70 (74 kDa) on the surface of monocytes during lipopolysaccharide (LPS) signaling and evidence that LPS inhibits dengue virus infection, the presence of ..
- Soluble cell adhesion molecules in monocytes of Alzheimer's disease and mild cognitive impairmentTanja Hochstrasser
Department of General and Social Psychiatry, Innsbruck Medical University, Austria
Exp Gerontol 45:70-4. 2010..The microglial compartment may arise to a greater part from activation and transmigration of circulating monocytes. The aim of the present pilot study was to explore, if different cell adhesion molecules (ICAM-1 and -3, PECAM-1,..
- Induction and regulatory function of miR-9 in human monocytes and neutrophils exposed to proinflammatory signalsFlavia Bazzoni
Department of Pathology, Division of General Pathology, University of Verona, Strada Le Grazie 8, I 37134 Verona, Italy
Proc Natl Acad Sci U S A 106:5282-7. 2009..study, we characterize the profile of miRNAs induced by LPS in human polymorphonuclear neutrophils (PMN) and monocytes. In particular, we identify miR-9 as the only miRNA (among 365 analyzed) up-regulated in both cell types after ..
- Oxidized low-density and high-density lipoproteins regulate the production of matrix metalloproteinase-1 and -9 by activated monocytesJeanette A Ardans
Immunopathology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, USA
J Leukoc Biol 71:1012-8. 2002b>Monocytes/macrophages are prominent in atherosclerotic plaques where the vascular remodeling and plaque rupture may be influenced by the lipids and cytokines at these sites...
- miR-198 inhibits HIV-1 gene expression and replication in monocytes and its mechanism of action appears to involve repression of cyclin T1Tzu Ling Sung
Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, United States of America
PLoS Pathog 5:e1000263. 2009..Translation of Cyclin T1 mRNA has been shown to be repressed in human monocytes, and this repression is relieved when cells differentiate to macrophages...
- CD38 orchestrates migration, survival, and Th1 immune response of human mature dendritic cellsLoredana Frasca
Department of Infectious, Parasitic, and Immune Mediated Diseases, Istituto Superiore di Sanita, Rome, Italy
Blood 107:2392-9. 2006..These findings may lay out the basis to assess the functional role(s) of human CD38 in infections, autoimmune diseases, and neoplastic disorders...
- Ly6c+ "inflammatory monocytes" are microglial precursors recruited in a pathogenic manner in West Nile virus encephalitisDaniel R Getts
The Discipline of Pathology, School of Medical Sciences, The University of Sydney, Sydney NSW 2006, Australia
J Exp Med 205:2319-37. 2008..Gr1(-)(Ly6C(lo))CX3CR1(+)) and "inflammatory" (Gr1(hi)/Ly6C(hi)/CCR2(+)) classical monocytes during infection abrogated the increase in microglia...
- High mobility group box 1 protein binding to lipopolysaccharide facilitates transfer of lipopolysaccharide to CD14 and enhances lipopolysaccharide-mediated TNF-alpha production in human monocytesJu Ho Youn
Department of Microbiology, Brain Korea 21 Project for Medical Science, National Core Research Center for Nanomedical Technology, Yonsei University College of Medicine, Seoul, Republic of Korea
J Immunol 180:5067-74. 2008..HMGB1 and LPS treatment results in a higher increase in TNF-alpha production in human PBMCs and peripheral blood monocytes than LPS or HMGB1 treatment alone or their summation...
- Vitamin D3 induces autophagy in human monocytes/macrophages via cathelicidinJae Min Yuk
Department of Microbiology, College of Medicine, Chungnam National University, Daejeon, Korea
Cell Host Microbe 6:231-43. 2009..We show that 1,25-dihydroxyvitamin D3 (1,25D3), the active form of vitamin D, induced autophagy in human monocytes via cathelicidin, which activated transcription of the autophagy-related genes Beclin-1 and Atg5...
- Comparison of gene expression profiles between human and mouse monocyte subsetsMolly A Ingersoll
Department of Gene and Cell Medicine and Immunology Institute, Mount Sinai School of Medicine, New York, NY, USA
Blood 115:e10-9. 2010..differences included a prominent peroxisome proliferator-activated receptor gamma (PPARgamma) signature in mouse monocytes, which is absent in humans, and strikingly opposed patterns of receptors involved in uptake of apoptotic cells ..
- Monocytes in atherosclerosis: subsets and functionsKevin J Woollard
Center for Molecular and Cellular Biology of Inflammation CMCBI, Division of Immunology, Infection and Inflammatory Diseases DIIID, Guys Campus, London SE1 1UL, UK
Nat Rev Cardiol 7:77-86. 2010..Plaque macrophages account for the majority of leukocytes in plaques, and are believed to differentiate from monocytes recruited from circulating blood. However, monocytes represent a heterogenous circulating population of cells...
- Cerebral microglia recruit monocytes into the brain in response to tumor necrosis factoralpha signaling during peripheral organ inflammationCharlotte D'Mello
Immunology Research Group, Department of Medicine, University of Calgary, Calgary, Alberta, Canada T2N 4N1
J Neurosci 29:2089-102. 2009..using a mouse model of inflammatory liver injury, we have confirmed the significant infiltration of activated monocytes into the brain in mice with hepatic inflammation and have defined the mechanism that mediates this trafficking ..
- Enolase-1 promotes plasminogen-mediated recruitment of monocytes to the acutely inflamed lungMalgorzata Wygrecka
Department of Biochemistry, Faculty of Medicine, University of Giessen Lung Center, Giessen, Germany
Blood 113:5588-98. 2009..LPS)-driven chemokine-directed monocyte migration and matrix invasion in vitro, as well as recruitment of monocytes to the alveolar compartment in vivo...
- Programmed death-1-induced interleukin-10 production by monocytes impairs CD4+ T cell activation during HIV infectionElias A Said
Centre de recherche du Centre hospitalier de l Université de Montréal CRCHUM, Hôpital St Luc, Montreal, Quebec, Canada
Nat Med 16:452-9. 2010..and inflammatory cytokines in the plasma of HIV-infected subjects lead to upregulation of PD-1 expression on monocytes that correlates with high plasma concentrations of IL-10...
- Type I interferon modulates monocyte recruitment and maturation in chronic inflammationPui Y Lee
Center for Autoimmune Disease, University of Florida, Gainesville, 32610 0221, USA
Am J Pathol 175:2023-33. 2009Chronic inflammation is characterized by continuous recruitment and activation of immune cells such as monocytes in response to a persistent stimulus...
- Homogeneous monocytes and macrophages from human embryonic stem cells following coculture-free differentiation in M-CSF and IL-3Karl R Karlsson
Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, UK
Exp Hematol 36:1167-75. 2008To develop a simple and efficient method for producing homogeneous populations of monocytes and macrophages from human embryonic stem cells (hES).
- Adiponectin primes human monocytes into alternative anti-inflammatory M2 macrophagesFina Lovren
Division of Cardiac Surgery, Keenan Research Centre in Li Ka Shing Knowledge Institute of St Michael s Hospital, Toronto, Ontario, Canada
Am J Physiol Heart Circ Physiol 299:H656-63. 2010..Because monocytes can differentiate into either proatherogenic M1 macrophages or anti-inflammatory M2 macrophages, approaches that ..
- Cyclic di-GMP signaling regulates invasion by Ehrlichia chaffeensis of human monocytesYumi Kumagai
Department of Veterinary Biosciences, The Ohio State University, Columbus, OH 43210, USA
J Bacteriol 192:4122-33. 2010..Furthermore, anti-HtrA inhibited CDGA-induced TRP120 degradation. Our results suggest that E. chaffeensis invasion is regulated by c-di-GMP signaling, which stabilizes some bacterial surface-exposed proteins against proteases...
- Monocytes from patients with type 1 diabetes spontaneously secrete proinflammatory cytokines inducing Th17 cellsElizabeth M Bradshaw
Division of Molecular Immunology, Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
J Immunol 183:4432-9. 2009..We examined the monocytes isolated directly from the blood of T1D patients and found they spontaneously secreted the proinflammatory ..
- Mycobacteria exploit p38 signaling to affect CD1 expression and lipid antigen presentation by human dendritic cellsMaria Cristina Gagliardi
Dipartimento di Malattie Infettive, Parassitarie e Immunomediate, Istituto Superiore di Sanita, Viale Regina Elena, 299, 00161 Roma, Italy
Infect Immun 77:4947-52. 2009..that Mycobacterium tuberculosis and bacillus Calmette-Guérin (Mycobacterium bovis BCG) induce human monocytes to differentiate into CD1- dendritic cells (DC), which cannot present lipid antigens to specific T cells...
- Quantitative expression of RIG-like helicase, NOD-like receptor and inflammasome-related mRNAs in humans and miceMaciej Lech
Medizinische Poliklinik, University of Munich, 80336 Munich, Germany
Int Immunol 22:717-28. 2010..Resting human and mouse monocytes and T cells expressed most molecules and produced IL-1 beta and CCL5/RANTES upon activation...
- Activated monocytes in peritumoral stroma of hepatocellular carcinoma foster immune privilege and disease progression through PD-L1Dong Ming Kuang
State Key Laboratory of Biocontrol, Sun Yat Sen University, Guangzhou 510 275, China
J Exp Med 206:1327-37. 2009..recently found that tumors can alter the normal developmental process of Mphi to trigger transient activation of monocytes in peritumoral stroma...
- HIV-1 transforms the monocyte plasma membrane proteomeIrena Kadiu
Department of Pharmacology and Experimental Neuroscience, Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, NE 68198 5880, USA
Cell Immunol 258:44-58. 2009..In contrast, PMA-treated monocytes bypassed caspase 3, 9 pathways and lead to cathepsin B-dependent necrosis...
- Sialoadhesin expressed on IFN-induced monocytes binds HIV-1 and enhances infectivityHans Rempel
Department of Laboratory Medicine at the Veterans Affairs Medical Center, San Francisco, California, United States of America
PLoS ONE 3:e1967. 2008HIV-1 infection dysregulates the immune system and alters gene expression in circulating monocytes. Differential gene expression analysis of CD14(+) monocytes from subjects infected with HIV-1 revealed increased expression of ..
- Inhibition of bone and muscle metastases of lung cancer cells by a decrease in the number of monocytes/macrophagesKoji Hiraoka
Department of Orthopedic Surgery, Kurume University Schoool of Medicine, Kurume 830 0011, Japan
Cancer Sci 99:1595-602. 2008..In this study, we examined the effect of a decrease in the number of monocytes/macrophages in peripheral blood and the tumor stroma on the development of bone and muscle metastases by lung ..
- Coronary intraplaque hemorrhage evokes a novel atheroprotective macrophage phenotypeJoseph J Boyle
Vascular Sciences Section, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0NN, U K
Am J Pathol 174:1097-108. 2009..Differentiating monocytes with HbHp complexes reproduced the CD163(high) human leukocyte antigen-DR(low) HA-mac phenotype in vitro...
- A new pathway of staphylococcal pathogenesis: apoptosis-like death induced by Staphopain B in human neutrophils and monocytesJan Smagur
Department of Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland
J Innate Immun 1:98-108. 2009Circulating neutrophils and monocytes form the first line of cellular defense against invading bacteria. Here, we describe a novel and specific mechanism of disabling and eliminating phagocytes by Staphylococcus aureus...
- Metalloproteinase expression in monocytes and macrophages and its relationship to atherosclerotic plaque instabilityAndrew C Newby
Bristol Heart Institute, Bristol Royal Infirmary, Bristol BS2 8HW, UK
Arterioscler Thromb Vasc Biol 28:2108-14. 2008..Moreover, recent evidence suggests that different macrophage phenotypes express characteristically different spectra of MMPs and their inhibitors. New therapies may result from targeting matrix MMP overproduction...
- Monocytes contribute to the atherosclerotic cap by transformation into fibrocytesH J Medbury
Vascular Biology Research Centre, Department of Surgery, University of Sydney, Westmead Hospital, Westmead, NSW, Australia
Int Angiol 27:114-23. 2008..Recent evidence suggests that circulating progenitors may be a source of these cells. We hypothesized that they may be fibrocytes bone-marrow derived cells that acquire SM-like characteristics, including the expression of SM alfa actin...
- Altered M1/M2 activation patterns of monocytes in severe relapsing experimental rat model of multiple sclerosis. Amelioration of clinical status by M2 activated monocyte administrationJoanna Mikita
University Victor Segalen, France
Mult Scler 17:2-15. 2011We investigated proinflammatory M1 and immunomodulatory M2 activation profiles of circulating monocytes in relapsing experimental autoimmune encephalomyelitis (EAE) model of multiple sclerosis, and tested whether altered M1/M2 ..
- The myeloid-related proteins 8 and 14 complex, a novel ligand of toll-like receptor 4, and interleukin-1beta form a positive feedback mechanism in systemic-onset juvenile idiopathic arthritisMichael Frosch
University of Muenster, Muenster, Germany
Arthritis Rheum 60:883-91. 2009..We undertook this study to analyze the relevance of myeloid-related proteins (MRPs) 8 and 14, endogenous activators of Toll-like receptor 4, in diagnosis and pathogenesis of systemic-onset JIA...
- Influence of bevacizumab, sunitinib and sorafenib as single agents or in combination on the inhibitory effects of VEGF on human dendritic cell differentiation from monocytesC Alfaro
Gene Therapy and Hepatology Division, CIMA, Universidad de Navarra, Pamplona, Spain
Br J Cancer 100:1111-9. 2009..of renal carcinoma cell lines cultured under hypoxia were found to alter the differentiation of human monocytes to DC. Resulting DC showed impaired activity, as assessed by the alloreactive mixed T-lymphocyte reaction...
- Analyses of all matrix metalloproteinase members in leukocytes emphasize monocytes as major inflammatory mediators in multiple sclerosisAmit Bar-Or
Montreal Neurological Institute, Quebec, Canada
Brain 126:2738-49. 2003..Of interest is the enrichment of a majority of MMP members in monocytes: MMP-1, MMP-3, MMP-9, MMP-10, MMP-14, MMP-19 and MMP-25...
- The phagocytes: neutrophils and monocytesDavid C Dale
Department of Medicine, University of Washington School of Medicine, Seattle A98195, USA
Blood 112:935-45. 2008..demonstrated the high production rate and short lifespan of neutrophils and allowed researchers to follow the monocytes as they moved from the marrow through the blood to become tissue macrophages, histiocytes, and dendritic cells...
- Enhanced expression of cytokines and chemokines by blood monocytes to in vitro lipopolysaccharide stimulation are associated with hostility and severity of depressive symptoms in healthy womenEdward C Suarez
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, P O Box 3328, Durham, NC 27710, USA
Psychoneuroendocrinology 29:1119-28. 2004..the relation of hostility and severity of depressive symptoms, separately and jointly, to the capacity of blood monocytes to secrete an array of cytokines when stimulated by bacterial lipopolysaccharide (LPS)...
- Activation of caspase-3 by the Dot/Icm virulence system is essential for arrested biogenesis of the Legionella-containing phagosomeMaelle Molmeret
Department of Microbiology and Immunology, University of Louisville College of Medicine, Louisville, KY 40292, USA
Cell Microbiol 6:33-48. 2004..Pretreatment of U937 macrophages and human peripheral blood monocytes (hPBM) with the capase-3 inhibitor (DEVD-fmk) or the paninhibitor of caspases (Z-VAD-fmk) before infection ..
- Myeloid differentiation and susceptibility to HIV-1 are linked to APOBEC3 expressionGang Peng
Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892 4352, USA
Blood 110:393-400. 2007..By comparison, circulating CD4(+)CCR5(+) monocytes appear relatively resistant to HIV-1, and a fundamental unresolved question involves deciphering restriction ..
- Soluble CD276 (B7-H3) is released from monocytes, dendritic cells and activated T cells and is detectable in normal human serumGuangbo Zhang
Clinical Immunology Laboratory, Suzhou University No 1 Affiliated Hospital, Suzhou, China
Immunology 123:538-46. 2008Expression of membrane CD276 (mB7-H3) has been reported on dendritic cells (DCs), monocytes, activated T cells, and various carcinoma cells. However, reports concerning its in vivo function have been inconsistent...
- Increased monocyte turnover from bone marrow correlates with severity of SIV encephalitis and CD163 levels in plasmaTricia H Burdo
Biology Department, Boston College, Chestnut Hill, Massachusetts, United States of America
PLoS Pathog 6:e1000842. 2010..b>Monocytes play critical roles in innate and adaptive immunity during inflammation...
- Phenotyping of peripheral blood mononuclear cells during acute dengue illness demonstrates infection and increased activation of monocytes in severe cases compared to classic dengue feverAnna P Durbin
Johns Hopkins Bloomberg School of Public Health, 624 North Broadway, Room 251, Baltimore, MD 21205, USA
Virology 376:429-35. 2008..DEN prM was detected primarily in activated monocytes (CD14(+), CD32(+), CD86(+), CD11c(+))...
- C1q and mannose binding lectin engagement of cell surface calreticulin and CD91 initiates macropinocytosis and uptake of apoptotic cellsC A Ogden
Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
J Exp Med 194:781-95. 2001....
- Identification of splenic reservoir monocytes and their deployment to inflammatory sitesFilip K Swirski
Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
Science 325:612-6. 2009A current paradigm states that monocytes circulate freely and patrol blood vessels but differentiate irreversibly into dendritic cells (DCs) or macrophages upon tissue entry...
- Molecular cloning of human eotaxin, an eosinophil-selective CC chemokine, and identification of a specific eosinophil eotaxin receptor, CC chemokine receptor 3M Kitaura
Shionogi Institute for Medical Science, Osaka, Japan
J Biol Chem 271:7725-30. 1996..produced in insect cells induced a calcium flux response in normal human eosinophils, but not in neutrophils or monocytes. The response could not be desensitized by pretreatment of eosinophils with other CC chemokines, suggesting a ..
- Expression of the serine protease inhibitor neuroserpin in cells of the human myeloid lineageSarah A Kennedy
School of Biological Sciences, Level 4, Thomas Building, University of Auckland, Private Bag 92019, Auckland 1010, New Zealand
Thromb Haemost 97:394-9. 2007..Neuroserpin was highly expressed and secreted following the differentiation of monocytes to macrophages and dendritic cells...
- VIP Inhibits Porphyromonas gingivalis LPS-induced immune responses in human monocytesN Foster
Oral Microbiology and Host Responses Group, School of Dental Sciences, University of Newcastle upon Tyne, NE2 4BW, UK
J Dent Res 84:999-1004. 2005..This is the first report to show the potential of VIP as an immunomodulator of Pg-stimulated inflammatory pathways in human monocytes.
- Impaired dendritic cell differentiation and maturation in the absence of C3Edimara S Reis
Departamento de Imunologia, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Av Professor Lineu Prestes 1730, 05508 900 Sao Paulo, SP, Brazil
Mol Immunol 45:1952-62. 2008Human monocytes can be differentiated into immature dendritic cells (DCs) in the presence of serum and cytokines. One of the main functions of immature DCs is to capture and process antigens...
- Activation of rainbow trout (Oncorhynchus mykiss) mononuclear phagocytes by different pathogen associated molecular pattern (PAMP) bearing agentsDimitar B Iliev
Great Lakes WATER Institute, University of Wisconsin Milwaukee, 600 E. Greenfield Ave, Milwaukee, WI 53204, USA
Mol Immunol 42:1215-23. 2005..By analogy to the type of stimulation observed in mammals it can be hypothesized that different signaling pathways, possibly initiated by different receptors, may be involved in the recognition of these PAMPs by rtMOCs...
- Differential activation of dendritic cells by nerve growth factor and brain-derived neurotrophic factorO Noga
Department of Infectious and Respiratory Diseases Charité, Universitatsmedizin Berlin, Berlin, Germany
Clin Exp Allergy 37:1701-8. 2007..Dendritic cells (DCs) play a major role in the induction of inflammatory processes with an increasing role in allergic diseases as well...
- Cytokine profiles of canine monocyte-derived dendritic cells as a function of lipopolysaccharide- or tumor necrosis factor-alpha-induced maturationYu Shan Wang
Animal Cancer Research Center, Department of Veterinary Medicine, National Taiwan University, 1 Roosevelt Road, Section 4, Taipei 106, Taiwan, ROC
Vet Immunol Immunopathol 118:186-98. 2007..Thus, canine DC maturing from different stimuli release different cytokine profiles that in turn promote different immune responses and activate innate and adaptive immune responses...
- LAG-3 (CD223) reduces macrophage and dendritic cell differentiation from monocyte precursorsSandrine Buisson
, , , France
Immunology 114:369-74. 2005Major histocompatibility complex (MHC) class II molecules expressed on monocytes may play a role in the control of differentiation of antigen-presenting cells...
- Airway epithelial cells modify immune responses by inducing an anti-inflammatory microenvironmentAnja K Mayer
Department of Hygiene and Medical Microbiology, University Heidelberg, Heidelberg, Germany
Eur J Immunol 38:1689-99. 2008..BEAS-2B bronchial epithelial cells inhibited secretion of the pro-inflammatory cytokines TNF-alpha and IL-12 by monocytes, macrophages and dendritic cells...
- Inorganic arsenite alters macrophage generation from human peripheral blood monocytesTeruaki Sakurai
Laboratory of Environmental Chemistry, School of Life Science, Tokyo University of Pharmacy and Life Science, Horinouchi, Hachioji, Tokyo 192 0392, Japan
Toxicol Appl Pharmacol 203:145-53. 2005..arsenite at nanomolar concentrations on the in vitro differentiation of human macrophages from peripheral blood monocytes. While arsenite was found to induce cell death in a culture system containing macrophage colony stimulating ..
- LPS-induced up-regulation of TGF-beta receptor 1 is associated with TNF-alpha expression in human monocyte-derived macrophagesYan Chen
Division of Paediatric Surgery, Department of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, China
J Leukoc Biol 83:1165-73. 2008..SB431542 had similar inhibitory effects on TNF-alpha production by human monocytes and endothelial cells as well as macrophages...
- Calcium/calmodulin-dependent kinase II is required for platelet-activating factor primingJoseph Cuschieri
Department of Surgery, University of Washington, Seattle, WA 98104, USA
Shock 23:99-106. 2005..This priming event is mediated in part by modulation of ERK 1/2, JNK/SAPK, NF-kappaB, and AP-1 activation. CaMK IV, on the other hand, is not specific for priming by PAF and appears to have a direct link in TLR4-mediated events...
- LPS-induced ROS generation and changes in glutathione level and their relation to the maturation of human monocyte-derived dendritic cellsHiroko Yamada
Department of Hematology and Oncology, Kyoto University Hospital, Kyoto 606-8507, Japan
Life Sci 78:926-33. 2006....
- Impaired maturation of monocyte-derived dendritic cells from birch allergic individuals in association with birch-specific immune responsesR Casas
Division of Paediatrics, Department of Molecular and Clinical Medicine, Faculty of Health Science, University of Linkoping, Linkoping, Sweden
Scand J Immunol 66:591-8. 2007..We investigated whether DC differentiated from monocytes from healthy and birch allergic asthmatic individuals and further maturated by stimulation with cat and birch ..
- Echinococcus granulosus antigen B impairs human dendritic cell differentiation and polarizes immature dendritic cell maturation towards a Th2 cell responseRachele Riganò
Dipartimento di Malattie Infettive, Parassitarie ed Immunomediate, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
Infect Immun 75:1667-78. 2007..granulosus-stimulated DC maturation. These results suggest that E. granulosus escapes host immunosurveillance in two ways: by interfering with monocyte differentiation and by modulating DC maturation...
- CCL20 production is induced in human dental pulp upon stimulation by Streptococcus mutans and proinflammatory cytokinesK Takahashi
Department of Conservative Dentistry, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Tokushima, Japan
Oral Microbiol Immunol 23:320-7. 2008..However, the mechanism of CCL20 expression remains unclear...
- Neisseria meningitidis type C capsular polysaccharide inhibits lipooligosaccharide-induced cell activation by binding to CD14Can Kocabas
Laboratory of Bacterial Polysaccharides, Center for Biologics Evaluation and Research, U S Food and Drug Administration, 1410 Rockville Pike HFM 428, Rockville, MD 20852 1448, USA
Cell Microbiol 9:1297-310. 2007..meningitidis (MCPS) inhibited LOS-induced interleukin-6 and TNF-alpha secretion from monocytes, and blocked the maturation of dendritic cells induced by LOS, while the capsular polysaccharide from group B ..
- Differentiation of human monocytes in vitro following exposure to Canova in the absence of cytokinesEureke Smit
Department of Anatomy, School of Medicine, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa
Ultrastruct Pathol 32:147-52. 2008..Since monocytes are the precursor cells of macrophages and dendritic cells, the objective of the current study was to ..
- Cadexomer as well as cadexomer iodine induces the production of proinflammatory cytokines and vascular endothelial growth factor by human macrophagesTomoyuki Ohtani
Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan
Exp Dermatol 16:318-23. 2007..Human macrophages were obtained by culturing CD14+ monocytes with macrophage colony stimulating factor (M-CSF) in the presence or absence of cadexomer or cadexomer iodine...
- Monocyte-derived dendritic cell function in chronic hepatitis C is impaired at physiological numbers of dendritic cellsA J MacDonald
iQur Ltd, Southampton General Hospital, Southampton, UK
Clin Exp Immunol 148:494-500. 2007..Because the functional defect was not apparent at high MoDC : T cell ratios, autologous MoDC therapy with sufficiently high numbers of DCs could, in theory, overcome any impairment of MoDC function in CHC...
- Expression of the alternative reading frame protein of Hepatitis C virus induces cytokines involved in hepatic injuriesMarc Fiorucci
FRE 2736 CNRS bioMérieux, IFR 128 Biosciences Lyon Gerland, Lyon, France
J Gen Virol 88:1149-62. 2007..This study was designed to evaluate the immunomodulatory functions of Core and ARFPs in monocytes, dendritic cells (DCs), macrophages (Mphi) and hepatocytes, cells that are all capable of supporting HCV ..
- alpha1-Antitrypsin regulates CD14 expression and soluble CD14 levels in human monocytes in vitroIzabela M Nita
Department of Clinical Sciences, Wallenberg Laboratory, University Hospital Malmo, Lund University, SE 20502 Malmo, Sweden
Int J Biochem Cell Biol 39:1165-76. 2007..In contrast, longer term incubation (18 h) of monocytes with combined AAT/LPS results in a significant reduction in expression of both CD14 and TLR4, inhibition of LPS-..
- Mixed Langerhans cell and interstitial/dermal dendritic cell subsets emanating from monocytes in Th2-mediated inflammatory conditions respond differently to proinflammatory stimuliNicolas Bechetoille
INSERM Unit 346, Human Skin and Immunity, EA No. 37-32, Claude Bernard University Lyon 1, Edouard Herriot Hospital, 69437 Lyon Cedex 03, France
J Leukoc Biol 80:45-58. 2006..To demonstrate that monocytes may act as DC precursors for skin DC in postinflammatory recolonization, we generated LC and IDDC from monocytes ..
- Lactoferrin acts as an alarmin to promote the recruitment and activation of APCs and antigen-specific immune responsesGonzalo de la Rosa
Laboratory of Molecular Immunoregulation, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, Fredrick, MD 21702, USA
J Immunol 180:6868-76. 2008..In this study, we show the ability of recombinant human lactoferrin (talactoferrin alfa (TLF)) to chemoattract monocytes. What is more, addition of TLF to human peripheral blood or monocyte-derived dendritic cell cultures resulted in ..
- Chloroquine inhibits production of TNF-alpha, IL-1beta and IL-6 from lipopolysaccharide-stimulated human monocytes/macrophages by different modesC-H Jang
Department of Biochemistry, College of Medicine, Catholic University of Korea, 505 Banpo-dong, Seocho-gu, Seoul 137-701, South Korea
Rheumatology (Oxford) 45:703-10. 2006..METHODS: Human peripheral blood mononuclear cells and monocytes/macrophages and monocytic U-937 and THP-1 cells were stimulated with lipopolysaccharide, and TNF-alpha, IL-1beta ..
- TNF-alpha drives human CD14+ monocytes to differentiate into CD70+ dendritic cells evoking Th1 and Th17 responsesSanju Iwamoto
Department of Biochemistry, School of Medicine, Showa University, Tokyo, Japan
J Immunol 179:1449-57. 2007..CD14(+) monocytes cultured in the presence of TNF-alpha and GM-CSF converted to CD14(+) CD1a(low) adherent cells with little ..
- Characterization of canine monocyte-derived dendritic cells with phenotypic and functional differentiationYu Shan Wang
Department of Veterinary Medicine, National Taiwan University
Can J Vet Res 71:165-74. 2007..The plasma enriched the population of CD14-positive monocytes by greatly enhancing the efficiency of monocyte adherence, the proportion of adherent cells increasing from 6...
- The cachectic mediator proteolysis inducing factor activates NF-kappaB and STAT3 in human Kupffer cells and monocytesTammy M Watchorn
Tissue Injury and Repair Group, Cell Injury and Apoptosis Section, Centre for Inflammation Research, University of Edinburgh, Edinburgh, UK
Int J Oncol 27:1105-11. 2005..able to activate pro-inflammatory pathways in human Kupffer cells, the resident macrophages of the liver, and in monocytes, resulting in the production of pro-inflammatory cytokines...
- Human ribonuclease A superfamily members, eosinophil-derived neurotoxin and pancreatic ribonuclease, induce dendritic cell maturation and activationDe Yang
Basic Research Program, Science Applications International Corporation SAIC Frederick, MD 21702, USA
J Immunol 173:6134-42. 2004..We therefore propose these mediators be considered as endogenous multifunctional immune alarmins...
- Inducible expression of PTX3, a new member of the pentraxin family, in human mononuclear phagocytesV V Alles
Laboratory of Immunology, Istituto di Ricerche Farmacologiche, Mario Negri, Milano, Italy
Blood 84:3483-93. 1994..Among leukocytes, only monocytes exposed to inflammatory cytokines or LPS expressed the PTX3 transcript, which was undetectable in resting or ..
- TNF skews monocyte differentiation from macrophages to dendritic cellsPascale Chomarat
Baylor Institute for Immunology Research, 3434 Live Oak, Dallas, TX 75204, USA
J Immunol 171:2262-9. 2003b>Monocytes represent a large pool of circulating precursors of APCs, both macrophages and dendritic cells (DCs). It is thus important to identify the mechanisms by which microenvironment regulates monocyte differentiation...
- Heterogeneous requirement of IkappaB kinase 2 for inflammatory cytokine and matrix metalloproteinase production in rheumatoid arthritis: implications for therapyEvangelos Andreakos
Kennedy Institute of Rheumatology, Imperial College of Science, Technology and Medicine, London, UK
Arthritis Rheum 48:1901-12. 2003....
- Leishmania (Leishmania) chagasi infection alters the expression of cell adhesion and costimulatory molecules on human monocyte and macrophageM C De Almeida
Faculdade de Medicina, Universidade Federal da Bahia Gonçalo Moniz, FIOCRUZ, Salvador, BA, Brazil
Int J Parasitol 33:153-62. 2003..There is limited information on the Leishmania infected human monocytes, the first cells that the parasite lives in, particularly related to costimulatory molecules...
- Inhibition of endotoxin response by e5564, a novel Toll-like receptor 4-directed endotoxin antagonistMaureen Mullarkey
Biology Section, Eisai Research Institute of Boston, Inc, Andover, Massachusetts, USA
J Pharmacol Exp Ther 304:1093-102. 2003..These results indicate that E5564 is a potent antagonist of LPS and lacks agonistic activity in human and animal model systems, making it a potentially effective therapeutic agent for treatment of disease states caused by endotoxin...
- Pertussis toxin and the adenylate cyclase toxin from Bordetella pertussis activate human monocyte-derived dendritic cells and dominantly inhibit cytokine production through a cAMP-dependent pathwayKenneth C Bagley
Division of Vaccine Research, Institute of Human Virology, University of Maryland Biotechnology Institute, and Department of Microbiology, University of Maryland School of Medicine, Baltimore 21201, USA
J Leukoc Biol 72:962-9. 2002..Also, cAMP-dependent kinase inhibitors blocked the ability of PT, AT, d-cAMP, and Forskolin to activate MDDC. Taken together, these results show that the effects of PT and AT on MDDC are mediated strictly by cAMP...
- Activation of terminally differentiated human monocytes/macrophages by dengue virus: productive infection, hierarchical production of innate cytokines and chemokines, and the synergistic effect of lipopolysaccharideYun Chi Chen
Laboratory of Hematology, Department of Medical Research and Education, Veterans General Hospital Taipei, Taipei, Taiwan, Republic of China
J Virol 76:9877-87. 2002Dengue virus (DV) primarily infects blood monocytes (MO) and tissue macrophages (M phi). We have shown in the present study that DV can productively infect primary human MO/M phi regardless of the stage of cell differentiation...
- The sesquiterpene lactone parthenolide inhibits LPS- but not TNF-alpha-induced maturation of human monocyte-derived dendritic cells by inhibition of the p38 mitogen-activated protein kinase pathwayHiroshi Uchi
Division of Immunology and Allergology, University of Geneva, Geneva, Switzerland
J Allergy Clin Immunol 110:269-76. 2002..Dendritic cells (DCs) are the most potent antigen-presenting cells, and the manipulation of DC maturation provides a strategy for the treatment of allergic and inflammatory diseases...
- The human EGF-TM7 family member EMR2 is a heterodimeric receptor expressed on myeloid cellsMark J Kwakkenbos
Laboratory for Experimental Immunology, Academic Medical Center, University of Amsterdam, The Netherlands
J Leukoc Biol 71:854-62. 2002..Highest expression levels were detected on the more mature CD16(+) blood monocytes, on macrophages, and on BDCA-3(+) myeloid DC, whereas little if any expression was found on granulocytes...
- Tumor-associated macrophages as a source of functional dendritic cells in ovarian cancer patientsChristina S Chu
Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Clin Immunol 102:291-301. 2002..Therefore, TAMs have potential use for either ex vivo or in vivo DC-based immunotherapy, particularly in individuals in which more conventional sources of DCs have been depleted...
- Adenovirus type 5 vectors induce dendritic cell differentiation in human CD14(+) monocytes cultured under serum-free conditionsLyudmila A Lyakh
Regulation of Cell Growth Laboratory, The Laboratory of Experimental Immunology, and the Mouse Cancer Genetics Program, National Cancer Institute at Frederick, MD 21702-1201, USA
Blood 99:600-8. 2002..by a model virus is capable of initiating dendritic cell (DC) differentiation, human CD14(+) peripheral blood monocytes were infected with replication-defective type 5 adenovirus...
- THE CHEMOKINE RECEPTOR CXCR-2 IN ATHEROSCLEROSISWilliam Boisvert; Fiscal Year: 2002..First they will determine if retention of lesion monocytes is greater in LDLR-/-, mIL-8RH+/+ than LDLR-/-, mIL-8RH-/- mice...
- REGULATION OF INDUCIBLE GENE EXPRESSION IN MONOCYTESNigel Mackman; Fiscal Year: 2007..Lipopolysaccharide (LPS [endotoxin]) from Gram-negative bacteria induces monocytes and endothelial cells to express the procoagulant protein tissue factor (TF), which initiates disseminated ..
- HO-1 and granuloma formation in TB pleurisyVeena B Antony; Fiscal Year: 2010..b>Monocytes are recruited to the site of tuberculous infection by the interaction of C-C chemokines, (mainly monocyte ..
- ADENINE DEOXYNUCLEOTIDE METABOLISM AND IMMUNE FUNCTIONDennis Carson; Fiscal Year: 1993Lymphocytes and monocytes are critical cells in the pathogenesis of immunodeficiency, autoimmune, and certain malignant diseases...
- MONOCYTE ADHESION TO ATHEROMA IN GENE TARGETED MICEKlaus Ley; Fiscal Year: 2000..An important component of atherosclerotic lesions is the presence of foam cells derived from blood monocytes which infiltrate the vessel wall at an early stage of lesion development...
- EMAP II, a molecular link of inflammation and apoptosis in pulmonary emphysema.Irina Petrache; Fiscal Year: 2010..effect of EMAP II on endothelial cells, coupled with its ability to activate and recruit pro-inflammatory monocytes, we hypothesize that excessive EMAP II release in response to cigarette smoking engages both lung endothelial ..
- EMAP II, a molecular link of inflammation and apoptosis in pulmonary emphysema.Matthias Clauss; Fiscal Year: 2009..effect of EMAP II on endothelial cells, coupled with its ability to activate and recruit pro-inflammatory monocytes, we hypothesize that excessive EMAP II release in response to cigarette smoking engages both lung endothelial ..
- HDL Modulation of monocyte function in endotoxemiaC Roger White; Fiscal Year: 2010..Under inflammatory conditions, monocytes infiltrate the artery wall and differentiate to either dendritic cells (DCs) or macrophages (MF)...
- HDL Modulation of monocyte function in endotoxemiaGeeta Datta; Fiscal Year: 2009..Under inflammatory conditions, monocytes infiltrate the artery wall and differentiate to either dendritic cells (DCs) or macrophages (MF)...
- HDL Modulation of monocyte function in endotoxemiaGeeta Datta; Fiscal Year: 2009..Under inflammatory conditions, monocytes infiltrate the artery wall and differentiate to either dendritic cells (DCs) or macrophages (MF)...
- ETHANOLS ROLE MEDIATION OF MONOCYTE IMMUNOSUPPRESSIONGyongyi Szabo; Fiscal Year: 2003..These experiments will define monocyte alterations leading to the combined immunosuppressive effects of in vivo ethanol uptake and trauma. ..
- REGULATION OF INDUCIBLE GENE EXPRESSION IN MONOCYTESNigel Mackman; Fiscal Year: 2009..Lipopolysaccharide (LPS [endotoxin]) from Gram-negative bacteria induces monocytes and endothelial cells to express the procoagulant protein tissue factor (TF), which initiates disseminated ..
- Differentiation/migratory fate of monocyte-derived cellsGwendalyn J Randolph; Fiscal Year: 2010..Indeed, no information is available on whether the two major subsets of monocytes are cleared from sites of inflammation by different mechanisms...
- MONOCYTE RECRUITMENT IN PLEUROPULMONARY TB IN AIDSVeena Antony; Fiscal Year: 2005..b>Monocytes are recruited to the site of tuberculous infection by the interaction of C-C chemokines, (mainly monocyte ..
- METALLOTHIONEIN, MERCURY AND MONOCYTE ACTIVATIONRUDOLFS ZALUPS; Fiscal Year: 2006..Activation is the acute phase response and respiratory burst undergone by monocytes (and other leukocytes) as a response to extracellular events and signals...
- Monocyte Modulation in LAgPSUZANNE BARBOUR; Fiscal Year: 2005..Several lines of evidence suggest that LAgP monocytes exhibit a unique phenotype...
- Lung Endothelial Barrier Function and its Deregulation by Sickle ErythrocytesSolomon Ofori Acquah; Fiscal Year: 2007..cells fulfill a central role in the response to inflammation by controlling the number of circulating monocytes recruited to interstitial tissue compartments...
- Monocyte Adhesion to Atheroma in Gene TargetedKlaus Ley; Fiscal Year: 2005Atherosclerosis is considered an inflammatory disease triggered by the entry of monocytes into the wall of large arteries, where they differentiate into macrophages and foam cells and promote growth and dedifferentiation of smooth ..
- Monocyte activation and the role of CD11c in obesity-linked metabolic syndromeHuaizhu Wu; Fiscal Year: 2010..CD11c is a b2 integrin primarily expressed on monocytes/macrophages and dendritic cells (DCs) that is a marker for monocyte/macrophage activation and participates in ..
- TRANSGENIC MICE, INFLAMMATION & THE ALZHEIMER PHENOTYPEMarcia N Gordon; Fiscal Year: 2010..As an alternative delivery method, we propose to evaluate the use of monocytes, cells normally found in blood, as vectors to transport therapeutic genes to the brain...
- Monocyte Adhesive Hyaluronan Structures in DiabetesAimin Wang; Fiscal Year: 2007..and proliferation of the glomerular mesangial cells, followed by a prominent glomerular infiltration of monocytes and macrophages...
- Dopamine alters CNS migration of uninfected and HIV infected leukocytes to SDF-1JOAN WEINBERGER BERMAN; Fiscal Year: 2010..Some studies have found that drug abuse increases the number of T lymphocytes and monocytes that enter the brain during HIV infection when compared to infected individuals without a history of drug abuse ..
- Dopamine alters CNS migration of uninfected and HIV infected leukocytes to SDF-1JOAN BERMAN; Fiscal Year: 2009..Some studies have found that drug abuse increases the number of T lymphocytes and monocytes that enter the brain during HIV infection when compared to infected individuals without a history of drug abuse ..
- Monocyte Pathogenesis: Regulation of NADPH OxidaseMARTHA CATHCART; Fiscal Year: 2007The production of superoxide anion (02-) by activated monocytes and neutrophils is an essential element of host defense and inflammation. 02- is generated via the enzyme complex, NADPH oxidase...