Genomes and Genes
Summary: Large, phagocytic mononuclear leukocytes produced in the vertebrate BONE MARROW and released into the BLOOD; contain a large, oval or somewhat indented nucleus surrounded by voluminous cytoplasm and numerous organelles.
Publications256 found, 100 shown here
- Development of monocytes, macrophages, and dendritic cellsFrederic Geissmann
Centre for Molecular and Cellular Biology of Inflammation, Division of Immunology, Infection, and Inflammatory Diseases, King s College London, Great Maze Pond, London SE1 1UL, UK
Science 327:656-61. 2010b>Monocytes and macrophages are critical effectors and regulators of inflammation and the innate immune response, the immediate arm of the immune system...
- Monocyte and macrophage heterogeneitySiamon Gordon
Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
Nat Rev Immunol 5:953-64. 2005..Circulating monocytes give rise to mature macrophages and are also heterogeneous themselves, although the physiological relevance of ..
- Genetics and beyond--the transcriptome of human monocytes and disease susceptibilityTanja Zeller
Medizinische Klinik und Poliklinik, Johannes Gutenberg Universitat Mainz, Mainz, Germany
PLoS ONE 5:e10693. 2010....
- Monocyte recruitment during infection and inflammationChao Shi
Infectious Diseases Service, Department of Medicine, Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, USA
Nat Rev Immunol 11:762-74. 2011b>Monocytes originate from progenitors in the bone marrow and traffic via the bloodstream to peripheral tissues...
- Monocyte chemoattractant protein-1 (MCP-1): an overviewSatish L Deshmane
Department of Neuroscience, Temple University School of Medicine, Philadelphia, PA 19140, USA
J Interferon Cytokine Res 29:313-26. 2009..Chemokines play a major role in selectively recruiting monocytes, neutrophils, and lymphocytes, as well as in inducing chemotaxis through the activation of G-protein-coupled ..
- Nomenclature of monocytes and dendritic cells in bloodLoems Ziegler-Heitbrock
Helmholtz Zentrum Munchen, Gauting, Germany
Blood 116:e74-80. 2010b>Monocytes and cells of the dendritic cell lineage circulate in blood and eventually migrate into tissue where they further mature and serve various functions, most notably in immune defense...
- CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasisBin Zhi Qian
Department of Developmental and Molecular Biology, Center for the Study of Reproductive Biology and Women s Health, Albert Einstein College of Medicine, New York, New York 10461, USA
Nature 475:222-5. 2011..Here we define the origin of these macrophages by showing that Gr1-positive inflammatory monocytes are preferentially recruited to pulmonary metastases but not to primary mammary tumours in mice...
- Identification of splenic reservoir monocytes and their deployment to inflammatory sitesFilip K Swirski
Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
Science 325:612-6. 2009A current paradigm states that monocytes circulate freely and patrol blood vessels but differentiate irreversibly into dendritic cells (DCs) or macrophages upon tissue entry...
- Monitoring of blood vessels and tissues by a population of monocytes with patrolling behaviorCedric Auffray
Institut Nationale de la Santé et de la Recherche Médicale INSERM U838, Laboratory of Biology of the Mononuclear Phagocyte System, and Cellular and Molecular imaging core facility, Institut Federatif de Recherche Necker Enfants Malades, Paris, France
Science 317:666-70. 2007..We have shown, by direct examination of blood monocyte functions in vivo, that a subset of monocytes patrols healthy tissues through long-range crawling on the resting endothelium...
- Microbial stimulation fully differentiates monocytes to DC-SIGN/CD209(+) dendritic cells for immune T cell areasCheolho Cheong
Chris Browne Center for Immunology and Immune Diseases, The Rockefeller University, New York, NY 10065, USA
Cell 143:416-29. 2010..critical antigen-presenting cells for immune control, normally derive from bone marrow precursors distinct from monocytes. It is not yet established if the large reservoir of monocytes can develop into cells with critical features of ..
- Transcriptional profiling of the human monocyte-to-macrophage differentiation and polarization: new molecules and patterns of gene expressionFernando O Martinez
Istituto Clinico Humanitas, Rozzano, Italy
J Immunol 177:7303-11. 2006..is associated with activation of cell cycle genes, substantiating the underestimated proliferation potential of monocytes. 2) M-CSF leads to expression of a substantial part of the M2 transcriptome, suggesting that under homeostatic ..
- In vivo analysis of dendritic cell development and homeostasisKang Liu
Laboratory of Molecular Immunology, Rockefeller University, New York, NY 10065, USA
Science 324:392-7. 2009Dendritic cells (DCs) in lymphoid tissue arise from precursors that also produce monocytes and plasmacytoid DCs (pDCs)...
- Monocyte-mediated defense against microbial pathogensNatalya V Serbina
Infectious Diseases Service, Department of Medicine, Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
Annu Rev Immunol 26:421-52. 2008Circulating blood monocytes supply peripheral tissues with macrophage and dendritic cell (DC) precursors and, in the setting of infection, also contribute directly to immune defense against microbial pathogens...
- Quantitative expression of toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotidesVeit Hornung
Department of Internal Medicine, Division of Clinical Pharmacology, University of Munich, Munich, Germany
J Immunol 168:4531-7. 2002..High expression of TLR2 was characteristic for monocytes. PDC and B cells expressed marked levels of TLR7 and TLR9 and were directly sensitive to CpG ODN...
- Monocyte subsets differentially employ CCR2, CCR5, and CX3CR1 to accumulate within atherosclerotic plaquesFrank Tacke
Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
J Clin Invest 117:185-94. 2007b>Monocytes participate critically in atherosclerosis. There are 2 major subsets expressing different chemokine receptor patterns: CCR2(+)CX3CR1(+)Ly-6C(hi) and CCR2(-)CX3CR1(++)Ly-6C(lo) monocytes...
- Human IL-23-producing type 1 macrophages promote but IL-10-producing type 2 macrophages subvert immunity to (myco)bacteriaFrank A W Verreck
Department of Immunohematology and Blood Transfusion, Leiden University Medical Centre, Albinusdreef 2, NL 2333 ZA, Leiden, The Netherlands
Proc Natl Acad Sci U S A 101:4560-5. 2004..Mphi heterogeneity thus may be an important determinant of immunity and disease outcome in intracellular bacterial infection...
- Infiltrating monocytes trigger EAE progression, but do not contribute to the resident microglia poolBahareh Ajami
University of British Columbia, Biomedical Research Centre, Vancouver, British Columbia, Canada
Nat Neurosci 14:1142-9. 2011..Inhibition of chemokine receptor-dependent recruitment of monocytes to the CNS blocked EAE progression, suggesting that these infiltrating cells are essential for pathogenesis...
- Inflammatory monocytes recruited after skeletal muscle injury switch into antiinflammatory macrophages to support myogenesisLudovic Arnold
Institut National de la Sante et de la Recherche Medicale, Unite 841, Institut Mondor de Recherche Biomedicale, Cell Interactions in the Neuromuscular System Team, Universite Paris 12 Val de Marne, Creteil, France
J Exp Med 204:1057-69. 2007..In conclusion, injured skeletal muscle recruits MOs exhibiting inflammatory profiles that operate phagocytosis and rapidly convert to antiinflammatory MPs that stimulate myogenesis and fiber growth...
- Gene expression profiling reveals the defining features of the classical, intermediate, and nonclassical human monocyte subsetsKok Loon Wong
Singapore Immunology Network, Agency for Science, Technology and Research, Singapore
Blood 118:e16-31. 2011New official nomenclature subdivides human monocytes into 3 subsets: the classical (CD14(++)CD16(-)), intermediate (CD14(++)CD16(+)), and nonclassical (CD14(+)CD16(++)) monocytes...
- Microglia in the adult brain arise from Ly-6ChiCCR2+ monocytes only under defined host conditionsAlexander Mildner
Institute of Neuropathology, Georg August University, Gottingen, Germany
Nat Neurosci 10:1544-53. 2007..a panel of bone marrow chimeric and adoptive transfer experiments, we found that circulating Ly-6C(hi)CCR2(+) monocytes were preferentially recruited to the lesioned brain and differentiated into microglia...
- LPS induction of gene expression in human monocytesM Guha
Departments of Immunology, C-204, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Cell Signal 13:85-94. 2001..Recent studies have elucidated how LPS is recognized by monocytes and macrophages of the innate immune system...
- The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functionsMatthias Nahrendorf
Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
J Exp Med 204:3037-47. 2007Healing of myocardial infarction (MI) requires monocytes/macrophages...
- Ly-6Chi monocytes dominate hypercholesterolemia-associated monocytosis and give rise to macrophages in atheromataFilip K Swirski
Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
J Clin Invest 117:195-205. 2007..Circulating monocytes, the precursors of macrophages, display heterogeneity in mice and humans, but their relative contribution to ..
- Human CD14dim monocytes patrol and sense nucleic acids and viruses via TLR7 and TLR8 receptorsJerome Cros
U838 INSERM, Universite Paris Descartes, Paris, France
Immunity 33:375-86. 2010b>Monocytes are effectors of the inflammatory response to microbes...
- Use of Ly6G-specific monoclonal antibody to deplete neutrophils in miceJean M Daley
Department of Surgery, Division of Surgical Research, Rhode Island Hospital, NAB 214, 593 Eddy Street, Providence, RI 02903, USA
J Leukoc Biol 83:64-70. 2008..and to Ly6C, which is expressed on neutrophils, dendritic cells, and subpopulations of lymphocytes and monocytes. It is thus likely that in vivo administration of RB6-8C5 may deplete not only neutrophils but also other Gr-l+ (..
- The CD14+ CD16+ blood monocytes: their role in infection and inflammationLoems Ziegler-Heitbrock
Department of Infection, Immunity and Inflammation, University of Leicester, Medical Sciences Building, University Road, Leicester, UK
J Leukoc Biol 81:584-92. 2007Blood monocyte subpopulations have been defined in man initially, and the two major types of monocytes are the CD14++ CD16- and the CD14+ CD16+ monocytes...
- Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivoMarie Luise von Brühl
Deutsches Herzzentrum and I Medizinische Klinik, Technische Universität München TUM, 80333 Munich, Germany
J Exp Med 209:819-35. 2012..We demonstrate by intravital two-photon and epifluorescence microscopy that blood monocytes and neutrophils crawling along and adhering to the venous endothelium provide the initiating stimulus for DVT ..
- Ghrelin inhibits leptin- and activation-induced proinflammatory cytokine expression by human monocytes and T cellsVishwa Deep Dixit
Laboratory of Immunology, National Institute on Aging, NIH, Baltimore, Maryland 21224, USA
J Clin Invest 114:57-66. 2004..Here we report that GHS-R and ghrelin are expressed in human T lymphocytes and monocytes, where ghrelin acts via GHS-R to specifically inhibit the expression of proinflammatory anorectic cytokines such ..
- Endotoxin tolerance: new mechanisms, molecules and clinical significanceSubhra K Biswas
Singapore Immunology Network, Biomedical Sciences Institutes, Agency for Science, Technology and Research, 04 01 Immunos, 8A Biomedical Drive, 138648 Singapore
Trends Immunol 30:475-87. 2009Prior exposure of innate immune cells like monocytes/macrophages to minute amounts of endotoxin cause them to become refractory to subsequent endotoxin challenge, a phenomenon called "endotoxin tolerance"...
- Monocyte emigration from bone marrow during bacterial infection requires signals mediated by chemokine receptor CCR2Natalya V Serbina
Infectious Disease Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, Immunology Program, Sloan Kettering Institute, New York, New York 10021, USA
Nat Immunol 7:311-7. 2006b>Monocytes recruited to tissues mediate defense against microbes or contribute to inflammatory diseases. Regulation of the number of circulating monocytes thus has implications for disease pathogenesis...
- SuperSAGE evidence for CD14++CD16+ monocytes as a third monocyte subsetAdam M Zawada
Department of Internal Medicine IV, Saarland University Hospital, Homburg Saar, Germany
Blood 118:e50-61. 2011b>Monocytes are a heterogeneous cell population with subset-specific functions and phenotypes...
- PVP-coated silver nanoparticles and silver ions induce reactive oxygen species, apoptosis and necrosis in THP-1 monocytesRasmus Foldbjerg
Department of Environmental and Occupational Medicine, Institute of Public Health, Aarhus University, Bartholins Alle 2, Bygn 1260, 8000 Aarhus, Denmark
Toxicol Lett 190:156-62. 2009..A drastic increase in ROS levels could be detected after 6-24h suggesting that oxidative stress is an important mediator of cytotoxicity caused by Ag NPs and Ag+...
- Cellular microRNA expression correlates with susceptibility of monocytes/macrophages to HIV-1 infectionXu Wang
Division of Allergy and Immunology, Joseph Stokes Jr Research Institute at The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
Blood 113:671-4. 2009Although both monocytes and macrophages possess essential requirements for HIV-1 entry, peripheral blood monocytes are infrequently infected with HIV-1 in vivo and in vitro...
- Induction and regulatory function of miR-9 in human monocytes and neutrophils exposed to proinflammatory signalsFlavia Bazzoni
Department of Pathology, Division of General Pathology, University of Verona, Strada Le Grazie 8, I 37134 Verona, Italy
Proc Natl Acad Sci U S A 106:5282-7. 2009..study, we characterize the profile of miRNAs induced by LPS in human polymorphonuclear neutrophils (PMN) and monocytes. In particular, we identify miR-9 as the only miRNA (among 365 analyzed) up-regulated in both cell types after ..
- Integrating genome-wide genetic variations and monocyte expression data reveals trans-regulated gene modules in humansMaxime Rotival
INSERM UMRS 937, Pierre and Marie Curie University UPMC, Paris 6 and Medical School, Paris, France
PLoS Genet 7:e1002367. 2011..multiple expression traits was replicated in Cardiogenics, an independent study in which expression profiles of monocytes were available in 758 subjects...
- Vaccine adjuvants alum and MF59 induce rapid recruitment of neutrophils and monocytes that participate in antigen transport to draining lymph nodesSamuele Calabro
Novartis Vaccines and Diagnostics, Siena, Italy
Vaccine 29:1812-23. 2011..The earliest and most abundantly recruited cell type are neutrophils, followed by monocytes, eosinophils and later dendritic cells (DCs) and macrophages...
- The multifaceted contributions of leukocyte subsets to atherosclerosis: lessons from mouse modelsChristian Weber
Institute for Molecular Cardiovascular Research, RWTH Aachen University, 52074 Aachen, Germany
Nat Rev Immunol 8:802-15. 2008..Improved understanding of the selective contributions of specific cell types to atherogenesis will pave the way for new targeted approaches to therapy...
- Blood monocytes consist of two principal subsets with distinct migratory propertiesFrederic Geissmann
Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
Immunity 19:71-82. 2003Peripheral blood monocytes are a heterogeneous population of circulating leukocytes...
- Type I interferon inhibits interleukin-1 production and inflammasome activationGreta Guarda
Department of Biochemistry, University of Lausanne, Epalinges, Switzerland
Immunity 34:213-23. 2011..Importantly, monocytes from multiple sclerosis patients undergoing IFN-β treatment produced substantially less IL-1β than monocytes ..
- beta-Amyloid stimulation of microglia and monocytes results in TNFalpha-dependent expression of inducible nitric oxide synthase and neuronal apoptosisC K Combs
Alzheimer Research Laboratory, Department of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
J Neurosci 21:1179-88. 2001..Importantly, TNFalpha generated by the monocytes and microglia was responsible for the majority of the neuorotoxic activity secreted by these cells after beta-..
- Experimental human cytomegalovirus latency in CD14+ monocytesDanna Hargett
Department of Molecular Biology, Princeton University, Princeton, NJ 08544 1014, USA
Proc Natl Acad Sci U S A 107:20039-44. 2010CD14(+) monocytes are a reservoir for latent human cytomegalovirus, and virus replication is reactivated during their differentiation to macrophages or dendritic cells...
- Vitamin D3 induces autophagy in human monocytes/macrophages via cathelicidinJae Min Yuk
Department of Microbiology, College of Medicine, Chungnam National University, Daejeon, Korea
Cell Host Microbe 6:231-43. 2009..We show that 1,25-dihydroxyvitamin D3 (1,25D3), the active form of vitamin D, induced autophagy in human monocytes via cathelicidin, which activated transcription of the autophagy-related genes Beclin-1 and Atg5...
- How is mRNA expression predictive for protein expression? A correlation study on human circulating monocytesYanfang Guo
Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Changsha 410081, China
Acta Biochim Biophys Sin (Shanghai) 40:426-36. 2008..We carried out correlation analyses on mRNA-protein expressions in freshly isolated human circulating monocytes from 30 unrelated women...
- Absence of monocyte chemoattractant protein-1 reduces atherosclerosis in low density lipoprotein receptor-deficient miceL Gu
Department of Adult Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
Mol Cell 2:275-81. 1998Recruitment of blood monocytes into the arterial subendothelium is one of the earliest steps in atherogenesis. Monocyte chemoattractant protein-1 (MCP-1), a CC chemokine, is one likely signal involved in this process...
- C-type lectins DC-SIGN and L-SIGN mediate cellular entry by Ebola virus in cis and in transCarmen P Alvarez
Laboratory of Molecular Microbiology, Dept of Microbiology, Hospital 12 de Octubre, 28041 Madrid, Spain
J Virol 76:6841-4. 2002..Our data underscore a role for DC-SIGN and L-SIGN in the infective process and pathogenicity of Ebola virus infection...
- ATP is released by monocytes stimulated with pathogen-sensing receptor ligands and induces IL-1beta and IL-18 secretion in an autocrine wayAlessandra Piccini
Cell Biology Unit, National Cancer Research Institute, Largo Rosanna Benzi 10, 16132 Genoa, Italy
Proc Natl Acad Sci U S A 105:8067-72. 2008..Here, we show that in primary human monocytes microbial components acting on different pathogen-sensing receptors and the danger-associated molecule uric acid ..
- Adult Langerhans cells derive predominantly from embryonic fetal liver monocytes with a minor contribution of yolk sac-derived macrophagesGuillaume Hoeffel
Singapore Immunology Network, Agency for Science, Technology and Research A STAR, Immunos Building 3 4, Biopolis, 138648, Singapore
J Exp Med 209:1167-81. 2012..which remain of YS origin throughout life, YS-derived LC precursors are largely replaced by fetal liver monocytes during late embryogenesis...
- Modulating inflammatory monocytes with a unique microRNA gene signature ameliorates murine ALSOleg Butovsky
Department of Neurology, Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
J Clin Invest 122:3063-87. 2012..Here we investigated the role of innate immunity in a mouse model of ALS. We found that inflammatory monocytes were activated and that their progressive recruitment to the spinal cord, but not brain, correlated with ..
- Circulating monocyte-platelet aggregates are a more sensitive marker of in vivo platelet activation than platelet surface P-selectin: studies in baboons, human coronary intervention, and human acute myocardial infarctionA D Michelson
Center for Platelet Function Studies, Departments of Pediatrics and Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
Circulation 104:1533-7. 2001..Platelet surface P-selectin is considered the "gold standard" marker of platelet activation. Degranulated, P-selectin-positive platelets, however, aggregate with leukocytes in vitro and rapidly lose surface P-selectin in vivo...
- Inhibition of anti-HIV microRNA expression: a mechanism for opioid-mediated enhancement of HIV infection of monocytesXu Wang
Department of Pathology and Laboratory Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
Am J Pathol 178:41-7. 2011..heroin), widely abused drugs among people infected with HIV, on the expression of cellular anti-HIV miRNAs in monocytes. We found that morphine-treated monocytes expressed lower levels of cellular anti-HIV miRNAs than untreated ..
- Inflammation switches the differentiation program of Ly6Chi monocytes from antiinflammatory macrophages to inflammatory dendritic cells in the colonAymeric Rivollier
Mucosal Immunobiology Section, Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Exp Med 209:139-55. 2012..In noninflammatory conditions, Ly6C(hi) monocytes (MOs) differentiated primarily into CD11c(+) but not CD11c(-) MPs...
- Activated monocytes in peritumoral stroma of hepatocellular carcinoma promote expansion of memory T helper 17 cellsDong Ming Kuang
State Key Laboratory of Oncology in Southern China, Cancer Center, Guangzhou, P R China
Hepatology 51:154-64. 2010..Most peritumoral CD68(+) cells exhibited an activated phenotype. Accordingly, tumor-activated monocytes were significantly superior to the suppressive tumor macrophages in inducing expansion of Th17 cells from ..
- Hepatitis C core and nonstructural 3 proteins trigger toll-like receptor 2-mediated pathways and inflammatory activationAngela Dolganiuc
Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
Gastroenterology 127:1513-24. 2004..reported that hepatitis C virus (HCV) core and nonstructural 3 (NS3) proteins activate inflammatory pathways in monocytes. The aim of this study was to investigate the role of TLRs in innate immune cell activation by core and NS3 ..
- Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-kappaBY Ogura
Department of Pathology and Comprehensive Cancer Center, The University of Michigan Medical School, Ann Arbor, MI 48109, USA
J Biol Chem 276:4812-8. 2001..Although Nod1 and Apaf-1 were broadly expressed in tissues, the expression of Nod2 was highly restricted to monocytes. Nod2 induced nuclear factor kappaB (NF-kappaB) activation, which required IKKgamma and was inhibited by ..
- miR-198 inhibits HIV-1 gene expression and replication in monocytes and its mechanism of action appears to involve repression of cyclin T1Tzu Ling Sung
Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, United States of America
PLoS Pathog 5:e1000263. 2009..Translation of Cyclin T1 mRNA has been shown to be repressed in human monocytes, and this repression is relieved when cells differentiate to macrophages...
- Altered M1/M2 activation patterns of monocytes in severe relapsing experimental rat model of multiple sclerosis. Amelioration of clinical status by M2 activated monocyte administrationJoanna Mikita
University Victor Segalen, France
Mult Scler 17:2-15. 2011We investigated proinflammatory M1 and immunomodulatory M2 activation profiles of circulating monocytes in relapsing experimental autoimmune encephalomyelitis (EAE) model of multiple sclerosis, and tested whether altered M1/M2 ..
- Regulation of scavenger receptor CD163 expression in human monocytes and macrophages by pro- and antiinflammatory stimuliC Buechler
Institut fur Klinische Chemie und Laboratoriumsmedizin, Klinikum der Universitat Regensburg, Germany
J Leukoc Biol 67:97-103. 2000..In freshly isolated monocytes the CD14bright CD16+ monocyte subset revealed the highest expression of CD163 among all monocyte subsets...
- Monocytes in atherosclerosis: subsets and functionsKevin J Woollard
Center for Molecular and Cellular Biology of Inflammation CMCBI, Division of Immunology, Infection and Inflammatory Diseases DIIID, Guys Campus, London SE1 1UL, UK
Nat Rev Cardiol 7:77-86. 2010..Plaque macrophages account for the majority of leukocytes in plaques, and are believed to differentiate from monocytes recruited from circulating blood. However, monocytes represent a heterogenous circulating population of cells...
- The phagocytes: neutrophils and monocytesDavid C Dale
Department of Medicine, University of Washington School of Medicine, Seattle A98195, USA
Blood 112:935-45. 2008..demonstrated the high production rate and short lifespan of neutrophils and allowed researchers to follow the monocytes as they moved from the marrow through the blood to become tissue macrophages, histiocytes, and dendritic cells...
- A distinguishing gene signature shared by tumor-infiltrating Tie2-expressing monocytes, blood "resident" monocytes, and embryonic macrophages suggests common functions and developmental relationshipsFerdinando Pucci
Angiogenesis and Tumor Targeting Research Unit, San Raffaele Institute, Olgettina 58, Milan, Italy
Blood 114:901-14. 2009We previously showed that Tie2-expressing monocytes (TEMs) have nonredundant proangiogenic activity in tumors...
- Differential requirement for the activation of the inflammasome for processing and release of IL-1beta in monocytes and macrophagesMihai G Netea
Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, USA
Blood 113:2324-35. 2009..Here we demonstrate that human blood monocytes release processed IL-1beta after a one-time stimulation with either TLR2 or TLR4 ligands, resulting from ..
- miR-146a is critical for endotoxin-induced tolerance: IMPLICATION IN INNATE IMMUNITYMd A Nahid
Department of Oral Biology, University of Florida, Gainesville, Florida 32610, USA
J Biol Chem 284:34590-9. 2009..Thus our studies demonstrated that miR-146a is critical for the in vitro monocytic cell-based endotoxin tolerance...
- Magnetic resonance tracking of dendritic cells in melanoma patients for monitoring of cellular therapyI Jolanda M de Vries
Department of Tumor Immunology, Radboud University Nijmegen Medical Center and Nijmegen Center for Molecular Life Sciences, Geert Grooteplein 28, 6500 HB Nijmegen, The Netherlands
Nat Biotechnol 23:1407-13. 2005..MRI cell tracking using iron oxides appears clinically safe and well suited to monitor cellular therapy in humans...
- The chemokine system in diverse forms of macrophage activation and polarizationAlberto Mantovani
Centro di Eccellenza per l Innovazione Diagnostica e Terapeutica IDET, Institute of General Pathology, University of Milan, I 20133 Milan, Italy Istituto di Ricerche Farmacologiche Mario Negri, I 20157 Milan, Italy
Trends Immunol 25:677-86. 2004....
- SIVSM/HIV-2 Vpx proteins promote retroviral escape from a proteasome-dependent restriction pathway present in human dendritic cellsCaroline Goujon
LaboRetro, INSERM U758, Ecole Normale Superieure de Lyon, IFR 128 Biosciences Lyon Gerland, Lyon Biopole, France
Retrovirology 4:2. 2007..However, since the requirement for Vpx is specific for DCs and not for other non-dividing cell types, this suggests that Vpx may play a role other than nuclear import...
- Altered redox state of monocytes from cryopyrin-associated periodic syndromes causes accelerated IL-1beta secretionSara Tassi
Cell Biology Unit, National Cancer Research Institute, 16132 Genoa, Italy
Proc Natl Acad Sci U S A 107:9789-94. 2010In healthy monocytes, Toll-like receptor (TLR) engagement induces production of reactive oxygen species (ROS), followed by an antioxidant response involved in IL-1beta processing and secretion...
- Apoptosis-associated speck-like protein (ASC) controls Legionella pneumophila infection in human monocytesDalia H Abdelaziz
Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Center for Microbial Interface Biology and the Department of Internal Medicine, Ohio State University, Columbus, Ohio 43210, USA
J Biol Chem 286:3203-8. 2011..pneumophila to cause pneumonia is determined by its capability to evade the immune system and grow within human monocytes and their derived macrophages...
- The identification of markers of macrophage differentiation in PMA-stimulated THP-1 cells and monocyte-derived macrophagesMarc Daigneault
Department of Infection and Immunity, Medical School, University of Sheffield, Sheffield, United Kingdom
PLoS ONE 5:e8668. 2010..cell line after various protocols of differentiation utilising VD(3) and PMA in comparison to primary human monocytes or monocyte-derived macrophages (MDM)...
- A cellular restriction dictates the permissivity of nondividing monocytes/macrophages to lentivirus and gammaretrovirus infectionRajnish Kaushik
Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
Cell Host Microbe 6:68-80. 2009..We further demonstrate that this restriction prevents transduction of quiescent monocytes by HIV-1...
- Soluble cell adhesion molecules in monocytes of Alzheimer's disease and mild cognitive impairmentTanja Hochstrasser
Department of General and Social Psychiatry, Innsbruck Medical University, Austria
Exp Gerontol 45:70-4. 2010..The microglial compartment may arise to a greater part from activation and transmigration of circulating monocytes. The aim of the present pilot study was to explore, if different cell adhesion molecules (ICAM-1 and -3, PECAM-1,..
- Interaction of Vpx and apolipoprotein B mRNA-editing catalytic polypeptide 3 family member A (APOBEC3A) correlates with efficient lentivirus infection of monocytesAndre Berger
Division of Medical Biotechnology, Paul Ehrlich Institut, 63225 Langen, Germany
J Biol Chem 285:12248-54. 2010..HIV-1, which does not encode Vpx, is not able to infect human monocytes, but Vpx enables infection with HIV-1. The underlying mechanism is not completely understood...
- Heat shock protein 90 and heat shock protein 70 are components of dengue virus receptor complex in human cellsJorge Reyes-Del Valle
Departamento de Patologia Experimental, Centro de Investigacion y de Estudios Avanzados del IPN, Av I P N 2508, Col San Pedro Zacatenco, Mexico City D F, C P 07360, Mexico
J Virol 79:4557-67. 2005..Based on the ability of HSP90 (84 kDa) to interact with HSP70 (74 kDa) on the surface of monocytes during lipopolysaccharide (LPS) signaling and evidence that LPS inhibits dengue virus infection, the presence of ..
- Circulating monocytes from systemic sclerosis patients with interstitial lung disease show an enhanced profibrotic phenotypeSusan K Mathai
Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA
Lab Invest 90:812-23. 2010Profibrotic cells derived from circulating CD14+ monocytes include fibrocytes and alternatively activated macrophages...
- Migrating monocytes recruited to the spleen play an important role in control of blood stage malariaAnne Marit Sponaas
Division of Parasitology, Medical Research Council MRC National Institute for Medical Research, London, UK
Blood 114:5522-31. 2009..During Plasmodium chabaudi infection in mice, a population of CD11b(high)Ly6C(+) monocytes are generated in bone marrow, most of which depend on the chemokine receptor CCR2 for migration from bone marrow ..
- CD38 orchestrates migration, survival, and Th1 immune response of human mature dendritic cellsLoredana Frasca
Department of Infectious, Parasitic, and Immune Mediated Diseases, Istituto Superiore di Sanita, Rome, Italy
Blood 107:2392-9. 2006..These findings may lay out the basis to assess the functional role(s) of human CD38 in infections, autoimmune diseases, and neoplastic disorders...
- Oxidized low-density and high-density lipoproteins regulate the production of matrix metalloproteinase-1 and -9 by activated monocytesJeanette A Ardans
Immunopathology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, USA
J Leukoc Biol 71:1012-8. 2002b>Monocytes/macrophages are prominent in atherosclerotic plaques where the vascular remodeling and plaque rupture may be influenced by the lipids and cytokines at these sites...
- Cerebral microglia recruit monocytes into the brain in response to tumor necrosis factoralpha signaling during peripheral organ inflammationCharlotte D'Mello
Immunology Research Group, Department of Medicine, University of Calgary, Calgary, Alberta, Canada T2N 4N1
J Neurosci 29:2089-102. 2009..using a mouse model of inflammatory liver injury, we have confirmed the significant infiltration of activated monocytes into the brain in mice with hepatic inflammation and have defined the mechanism that mediates this trafficking ..
- Programmed death-1-induced interleukin-10 production by monocytes impairs CD4+ T cell activation during HIV infectionElias A Said
Centre de recherche du Centre hospitalier de l Université de Montréal CRCHUM, Hôpital St Luc, Montreal, Quebec, Canada
Nat Med 16:452-9. 2010..and inflammatory cytokines in the plasma of HIV-infected subjects lead to upregulation of PD-1 expression on monocytes that correlates with high plasma concentrations of IL-10...
- Enolase-1 promotes plasminogen-mediated recruitment of monocytes to the acutely inflamed lungMalgorzata Wygrecka
Department of Biochemistry, Faculty of Medicine, University of Giessen Lung Center, Giessen, Germany
Blood 113:5588-98. 2009..LPS)-driven chemokine-directed monocyte migration and matrix invasion in vitro, as well as recruitment of monocytes to the alveolar compartment in vivo...
- Comparison of gene expression profiles between human and mouse monocyte subsetsMolly A Ingersoll
Department of Gene and Cell Medicine and Immunology Institute, Mount Sinai School of Medicine, New York, NY, USA
Blood 115:e10-9. 2010..differences included a prominent peroxisome proliferator-activated receptor gamma (PPARgamma) signature in mouse monocytes, which is absent in humans, and strikingly opposed patterns of receptors involved in uptake of apoptotic cells ..
- Ly6c+ "inflammatory monocytes" are microglial precursors recruited in a pathogenic manner in West Nile virus encephalitisDaniel R Getts
The Discipline of Pathology, School of Medical Sciences, The University of Sydney, Sydney NSW 2006, Australia
J Exp Med 205:2319-37. 2008..Depletion of "circulating" (Gr1(-)(Ly6C(lo))CX3CR1(+)) and "inflammatory" (Gr1(hi)/Ly6C(hi)/CCR2(+)) classical monocytes during infection abrogated the increase in microglia...
- High mobility group box 1 protein binding to lipopolysaccharide facilitates transfer of lipopolysaccharide to CD14 and enhances lipopolysaccharide-mediated TNF-alpha production in human monocytesJu Ho Youn
Department of Microbiology, Brain Korea 21 Project for Medical Science, National Core Research Center for Nanomedical Technology, Yonsei University College of Medicine, Seoul, Republic of Korea
J Immunol 180:5067-74. 2008..HMGB1 and LPS treatment results in a higher increase in TNF-alpha production in human PBMCs and peripheral blood monocytes than LPS or HMGB1 treatment alone or their summation...
- Influence of bevacizumab, sunitinib and sorafenib as single agents or in combination on the inhibitory effects of VEGF on human dendritic cell differentiation from monocytesC Alfaro
Gene Therapy and Hepatology Division, CIMA, Universidad de Navarra, Pamplona, Spain
Br J Cancer 100:1111-9. 2009..of renal carcinoma cell lines cultured under hypoxia were found to alter the differentiation of human monocytes to DC. Resulting DC showed impaired activity, as assessed by the alloreactive mixed T-lymphocyte reaction...
- Metalloproteinase expression in monocytes and macrophages and its relationship to atherosclerotic plaque instabilityAndrew C Newby
Bristol Heart Institute, Bristol Royal Infirmary, Bristol BS2 8HW, UK
Arterioscler Thromb Vasc Biol 28:2108-14. 2008..Moreover, recent evidence suggests that different macrophage phenotypes express characteristically different spectra of MMPs and their inhibitors. New therapies may result from targeting matrix MMP overproduction...
- Coronary intraplaque hemorrhage evokes a novel atheroprotective macrophage phenotypeJoseph J Boyle
Vascular Sciences Section, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0NN, U K
Am J Pathol 174:1097-108. 2009..Differentiating monocytes with HbHp complexes reproduced the CD163(high) human leukocyte antigen-DR(low) HA-mac phenotype in vitro...
- A new pathway of staphylococcal pathogenesis: apoptosis-like death induced by Staphopain B in human neutrophils and monocytesJan Smagur
Department of Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland
J Innate Immun 1:98-108. 2009Circulating neutrophils and monocytes form the first line of cellular defense against invading bacteria. Here, we describe a novel and specific mechanism of disabling and eliminating phagocytes by Staphylococcus aureus...
- Monocytes from patients with type 1 diabetes spontaneously secrete proinflammatory cytokines inducing Th17 cellsElizabeth M Bradshaw
Division of Molecular Immunology, Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
J Immunol 183:4432-9. 2009..We examined the monocytes isolated directly from the blood of T1D patients and found they spontaneously secreted the proinflammatory ..
- Mycobacteria exploit p38 signaling to affect CD1 expression and lipid antigen presentation by human dendritic cellsMaria Cristina Gagliardi
Dipartimento di Malattie Infettive, Parassitarie e Immunomediate, Istituto Superiore di Sanita, Viale Regina Elena, 299, 00161 Roma, Italy
Infect Immun 77:4947-52. 2009..that Mycobacterium tuberculosis and bacillus Calmette-Guérin (Mycobacterium bovis BCG) induce human monocytes to differentiate into CD1- dendritic cells (DC), which cannot present lipid antigens to specific T cells...
- Homogeneous monocytes and macrophages from human embryonic stem cells following coculture-free differentiation in M-CSF and IL-3Karl R Karlsson
Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, UK
Exp Hematol 36:1167-75. 2008To develop a simple and efficient method for producing homogeneous populations of monocytes and macrophages from human embryonic stem cells (hES).
- HIV-1 transforms the monocyte plasma membrane proteomeIrena Kadiu
Department of Pharmacology and Experimental Neuroscience, Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, NE 68198 5880, USA
Cell Immunol 258:44-58. 2009..In contrast, PMA-treated monocytes bypassed caspase 3, 9 pathways and lead to cathepsin B-dependent necrosis...
- Quantitative expression of RIG-like helicase, NOD-like receptor and inflammasome-related mRNAs in humans and miceMaciej Lech
Medizinische Poliklinik, University of Munich, 80336 Munich, Germany
Int Immunol 22:717-28. 2010..Resting human and mouse monocytes and T cells expressed most molecules and produced IL-1 beta and CCL5/RANTES upon activation...
- Sialoadhesin expressed on IFN-induced monocytes binds HIV-1 and enhances infectivityHans Rempel
Department of Laboratory Medicine at the Veterans Affairs Medical Center, San Francisco, California, United States of America
PLoS ONE 3:e1967. 2008HIV-1 infection dysregulates the immune system and alters gene expression in circulating monocytes. Differential gene expression analysis of CD14(+) monocytes from subjects infected with HIV-1 revealed increased expression of ..
- Adiponectin primes human monocytes into alternative anti-inflammatory M2 macrophagesFina Lovren
Division of Cardiac Surgery, Keenan Research Centre in Li Ka Shing Knowledge Institute of St Michael s Hospital, Toronto, Ontario, Canada
Am J Physiol Heart Circ Physiol 299:H656-63. 2010..Because monocytes can differentiate into either proatherogenic M1 macrophages or anti-inflammatory M2 macrophages, approaches that ..
- Cyclic di-GMP signaling regulates invasion by Ehrlichia chaffeensis of human monocytesYumi Kumagai
Department of Veterinary Biosciences, The Ohio State University, Columbus, OH 43210, USA
J Bacteriol 192:4122-33. 2010..Furthermore, anti-HtrA inhibited CDGA-induced TRP120 degradation. Our results suggest that E. chaffeensis invasion is regulated by c-di-GMP signaling, which stabilizes some bacterial surface-exposed proteins against proteases...
- Monocytes contribute to the atherosclerotic cap by transformation into fibrocytesH J Medbury
Vascular Biology Research Centre, Department of Surgery, University of Sydney, Westmead Hospital, Westmead, NSW, Australia
Int Angiol 27:114-23. 2008..Recent evidence suggests that circulating progenitors may be a source of these cells. We hypothesized that they may be fibrocytes bone-marrow derived cells that acquire SM-like characteristics, including the expression of SM alfa actin...
- Type I interferon modulates monocyte recruitment and maturation in chronic inflammationPui Y Lee
Center for Autoimmune Disease, University of Florida, Gainesville, 32610 0221, USA
Am J Pathol 175:2023-33. 2009Chronic inflammation is characterized by continuous recruitment and activation of immune cells such as monocytes in response to a persistent stimulus...
- Activated monocytes in peritumoral stroma of hepatocellular carcinoma foster immune privilege and disease progression through PD-L1Dong Ming Kuang
State Key Laboratory of Biocontrol, Sun Yat Sen University, Guangzhou 510 275, China
J Exp Med 206:1327-37. 2009..recently found that tumors can alter the normal developmental process of Mphi to trigger transient activation of monocytes in peritumoral stroma...
- The myeloid-related proteins 8 and 14 complex, a novel ligand of toll-like receptor 4, and interleukin-1beta form a positive feedback mechanism in systemic-onset juvenile idiopathic arthritisMichael Frosch
University of Muenster, Muenster, Germany
Arthritis Rheum 60:883-91. 2009..We undertook this study to analyze the relevance of myeloid-related proteins (MRPs) 8 and 14, endogenous activators of Toll-like receptor 4, in diagnosis and pathogenesis of systemic-onset JIA...
- Inhibition of bone and muscle metastases of lung cancer cells by a decrease in the number of monocytes/macrophagesKoji Hiraoka
Department of Orthopedic Surgery, Kurume University Schoool of Medicine, Kurume 830 0011, Japan
Cancer Sci 99:1595-602. 2008..In this study, we examined the effect of a decrease in the number of monocytes/macrophages in peripheral blood and the tumor stroma on the development of bone and muscle metastases by lung ..
- Phenotyping of peripheral blood mononuclear cells during acute dengue illness demonstrates infection and increased activation of monocytes in severe cases compared to classic dengue feverAnna P Durbin
Johns Hopkins Bloomberg School of Public Health, 624 North Broadway, Room 251, Baltimore, MD 21205, USA
Virology 376:429-35. 2008..DEN prM was detected primarily in activated monocytes (CD14(+), CD32(+), CD86(+), CD11c(+))...
- Soluble CD276 (B7-H3) is released from monocytes, dendritic cells and activated T cells and is detectable in normal human serumGuangbo Zhang
Clinical Immunology Laboratory, Suzhou University No 1 Affiliated Hospital, Suzhou, China
Immunology 123:538-46. 2008Expression of membrane CD276 (mB7-H3) has been reported on dendritic cells (DCs), monocytes, activated T cells, and various carcinoma cells. However, reports concerning its in vivo function have been inconsistent...
- THE CHEMOKINE RECEPTOR CXCR-2 IN ATHEROSCLEROSISWilliam Boisvert; Fiscal Year: 2002..First they will determine if retention of lesion monocytes is greater in LDLR-/-, mIL-8RH+/+ than LDLR-/-, mIL-8RH-/- mice...
- REGULATION OF INDUCIBLE GENE EXPRESSION IN MONOCYTESNigel Mackman; Fiscal Year: 2007..Lipopolysaccharide (LPS [endotoxin]) from Gram-negative bacteria induces monocytes and endothelial cells to express the procoagulant protein tissue factor (TF), which initiates disseminated ..
- HO-1 and granuloma formation in TB pleurisyVeena B Antony; Fiscal Year: 2010..b>Monocytes are recruited to the site of tuberculous infection by the interaction of C-C chemokines, (mainly monocyte ..
- ADENINE DEOXYNUCLEOTIDE METABOLISM AND IMMUNE FUNCTIONDennis Carson; Fiscal Year: 1993Lymphocytes and monocytes are critical cells in the pathogenesis of immunodeficiency, autoimmune, and certain malignant diseases...
- MONOCYTE ADHESION TO ATHEROMA IN GENE TARGETED MICEKlaus Ley; Fiscal Year: 2000..An important component of atherosclerotic lesions is the presence of foam cells derived from blood monocytes which infiltrate the vessel wall at an early stage of lesion development...
- EMAP II, a molecular link of inflammation and apoptosis in pulmonary emphysema.Matthias Clauss; Fiscal Year: 2009..effect of EMAP II on endothelial cells, coupled with its ability to activate and recruit pro-inflammatory monocytes, we hypothesize that excessive EMAP II release in response to cigarette smoking engages both lung endothelial ..
- EMAP II, a molecular link of inflammation and apoptosis in pulmonary emphysema.Irina Petrache; Fiscal Year: 2010..effect of EMAP II on endothelial cells, coupled with its ability to activate and recruit pro-inflammatory monocytes, we hypothesize that excessive EMAP II release in response to cigarette smoking engages both lung endothelial ..
- HDL Modulation of monocyte function in endotoxemiaC Roger White; Fiscal Year: 2010..Under inflammatory conditions, monocytes infiltrate the artery wall and differentiate to either dendritic cells (DCs) or macrophages (MF)...
- HDL Modulation of monocyte function in endotoxemiaGeeta Datta; Fiscal Year: 2009..Under inflammatory conditions, monocytes infiltrate the artery wall and differentiate to either dendritic cells (DCs) or macrophages (MF)...
- HDL Modulation of monocyte function in endotoxemiaGeeta Datta; Fiscal Year: 2009..Under inflammatory conditions, monocytes infiltrate the artery wall and differentiate to either dendritic cells (DCs) or macrophages (MF)...
- REGULATION OF INDUCIBLE GENE EXPRESSION IN MONOCYTESNigel Mackman; Fiscal Year: 2009..Lipopolysaccharide (LPS [endotoxin]) from Gram-negative bacteria induces monocytes and endothelial cells to express the procoagulant protein tissue factor (TF), which initiates disseminated ..
- Differentiation/migratory fate of monocyte-derived cellsGwendalyn J Randolph; Fiscal Year: 2010..Indeed, no information is available on whether the two major subsets of monocytes are cleared from sites of inflammation by different mechanisms...
- MONOCYTE RECRUITMENT IN PLEUROPULMONARY TB IN AIDSVeena Antony; Fiscal Year: 2005..b>Monocytes are recruited to the site of tuberculous infection by the interaction of C-C chemokines, (mainly monocyte ..
- METALLOTHIONEIN, MERCURY AND MONOCYTE ACTIVATIONRUDOLFS ZALUPS; Fiscal Year: 2006..Activation is the acute phase response and respiratory burst undergone by monocytes (and other leukocytes) as a response to extracellular events and signals...
- Monocyte Modulation in LAgPSUZANNE BARBOUR; Fiscal Year: 2005..Several lines of evidence suggest that LAgP monocytes exhibit a unique phenotype...
- Lung Endothelial Barrier Function and its Deregulation by Sickle ErythrocytesSolomon Ofori Acquah; Fiscal Year: 2007..cells fulfill a central role in the response to inflammation by controlling the number of circulating monocytes recruited to interstitial tissue compartments...
- Monocyte Adhesion to Atheroma in Gene TargetedKlaus Ley; Fiscal Year: 2005Atherosclerosis is considered an inflammatory disease triggered by the entry of monocytes into the wall of large arteries, where they differentiate into macrophages and foam cells and promote growth and dedifferentiation of smooth ..
- ETHANOLS ROLE MEDIATION OF MONOCYTE IMMUNOSUPPRESSIONGyongyi Szabo; Fiscal Year: 2003..These experiments will define monocyte alterations leading to the combined immunosuppressive effects of in vivo ethanol uptake and trauma. ..
- Monocyte activation and the role of CD11c in obesity-linked metabolic syndromeHuaizhu Wu; Fiscal Year: 2010..CD11c is a b2 integrin primarily expressed on monocytes/macrophages and dendritic cells (DCs) that is a marker for monocyte/macrophage activation and participates in ..
- TRANSGENIC MICE, INFLAMMATION & THE ALZHEIMER PHENOTYPEMarcia N Gordon; Fiscal Year: 2010..As an alternative delivery method, we propose to evaluate the use of monocytes, cells normally found in blood, as vectors to transport therapeutic genes to the brain...
- Monocyte Adhesive Hyaluronan Structures in DiabetesAimin Wang; Fiscal Year: 2007..and proliferation of the glomerular mesangial cells, followed by a prominent glomerular infiltration of monocytes and macrophages...
- Dopamine alters CNS migration of uninfected and HIV infected leukocytes to SDF-1JOAN BERMAN; Fiscal Year: 2009..Some studies have found that drug abuse increases the number of T lymphocytes and monocytes that enter the brain during HIV infection when compared to infected individuals without a history of drug abuse ..
- Dopamine alters CNS migration of uninfected and HIV infected leukocytes to SDF-1JOAN WEINBERGER BERMAN; Fiscal Year: 2010..Some studies have found that drug abuse increases the number of T lymphocytes and monocytes that enter the brain during HIV infection when compared to infected individuals without a history of drug abuse ..
- Monocyte Pathogenesis: Regulation of NADPH OxidaseMARTHA CATHCART; Fiscal Year: 2007The production of superoxide anion (02-) by activated monocytes and neutrophils is an essential element of host defense and inflammation. 02- is generated via the enzyme complex, NADPH oxidase...