monocytes

Summary

Summary: Large, phagocytic mononuclear leukocytes produced in the vertebrate BONE MARROW and released into the BLOOD; contain a large, oval or somewhat indented nucleus surrounded by voluminous cytoplasm and numerous organelles.

Top Publications

  1. ncbi Development of monocytes, macrophages, and dendritic cells
    Frederic Geissmann
    Centre for Molecular and Cellular Biology of Inflammation, Division of Immunology, Infection, and Inflammatory Diseases, King s College London, Great Maze Pond, London SE1 1UL, UK
    Science 327:656-61. 2010
  2. ncbi Genetics and beyond--the transcriptome of human monocytes and disease susceptibility
    Tanja Zeller
    Medizinische Klinik und Poliklinik, Johannes Gutenberg Universitat Mainz, Mainz, Germany
    PLoS ONE 5:e10693. 2010
  3. ncbi Activated monocytes in peritumoral stroma of hepatocellular carcinoma promote expansion of memory T helper 17 cells
    Dong Ming Kuang
    State Key Laboratory of Oncology in Southern China, Cancer Center, Guangzhou, P R China
    Hepatology 51:154-64. 2010
  4. ncbi The chemokine system in diverse forms of macrophage activation and polarization
    Alberto Mantovani
    Centro di Eccellenza per l Innovazione Diagnostica e Terapeutica IDET, Institute of General Pathology, University of Milan, I 20133 Milan, Italy Istituto di Ricerche Farmacologiche Mario Negri, I 20157 Milan, Italy
    Trends Immunol 25:677-86. 2004
  5. ncbi SIVSM/HIV-2 Vpx proteins promote retroviral escape from a proteasome-dependent restriction pathway present in human dendritic cells
    Caroline Goujon
    LaboRetro, INSERM U758, Ecole Normale Superieure de Lyon, IFR 128 Biosciences Lyon Gerland, Lyon Biopole, France
    Retrovirology 4:2. 2007
  6. ncbi The CD14+ CD16+ blood monocytes: their role in infection and inflammation
    Loems Ziegler-Heitbrock
    Department of Infection, Immunity and Inflammation, University of Leicester, Medical Sciences Building, University Road, Leicester, UK
    J Leukoc Biol 81:584-92. 2007
  7. ncbi The identification of markers of macrophage differentiation in PMA-stimulated THP-1 cells and monocyte-derived macrophages
    Marc Daigneault
    Department of Infection and Immunity, Medical School, University of Sheffield, Sheffield, United Kingdom
    PLoS ONE 5:e8668. 2010
  8. ncbi Human CD14dim monocytes patrol and sense nucleic acids and viruses via TLR7 and TLR8 receptors
    Jerome Cros
    U838 INSERM, Universite Paris Descartes, Paris, France
    Immunity 33:375-86. 2010
  9. ncbi Nomenclature of monocytes and dendritic cells in blood
    Loems Ziegler-Heitbrock
    Helmholtz Zentrum Munchen, Gauting, Germany
    Blood 116:e74-80. 2010
  10. ncbi Microbial stimulation fully differentiates monocytes to DC-SIGN/CD209(+) dendritic cells for immune T cell areas
    Cheolho Cheong
    Chris Browne Center for Immunology and Immune Diseases, The Rockefeller University, New York, NY 10065, USA
    Cell 143:416-29. 2010

Research Grants

  1. THE CHEMOKINE RECEPTOR CXCR-2 IN ATHEROSCLEROSIS
    William Boisvert; Fiscal Year: 2002
  2. REGULATION OF INDUCIBLE GENE EXPRESSION IN MONOCYTES
    Nigel Mackman; Fiscal Year: 2007
  3. HO-1 and granuloma formation in TB pleurisy
    Veena B Antony; Fiscal Year: 2010
  4. ADENINE DEOXYNUCLEOTIDE METABOLISM AND IMMUNE FUNCTION
    Dennis Carson; Fiscal Year: 1993
  5. MONOCYTE ADHESION TO ATHEROMA IN GENE TARGETED MICE
    Klaus Ley; Fiscal Year: 2000
  6. EMAP II, a molecular link of inflammation and apoptosis in pulmonary emphysema.
    Irina Petrache; Fiscal Year: 2010
  7. EMAP II, a molecular link of inflammation and apoptosis in pulmonary emphysema.
    Matthias Clauss; Fiscal Year: 2009
  8. HDL Modulation of monocyte function in endotoxemia
    C Roger White; Fiscal Year: 2010
  9. HDL Modulation of monocyte function in endotoxemia
    Geeta Datta; Fiscal Year: 2009
  10. HDL Modulation of monocyte function in endotoxemia
    Geeta Datta; Fiscal Year: 2009

Detail Information

Publications210 found, 100 shown here

  1. ncbi Development of monocytes, macrophages, and dendritic cells
    Frederic Geissmann
    Centre for Molecular and Cellular Biology of Inflammation, Division of Immunology, Infection, and Inflammatory Diseases, King s College London, Great Maze Pond, London SE1 1UL, UK
    Science 327:656-61. 2010
    b>Monocytes and macrophages are critical effectors and regulators of inflammation and the innate immune response, the immediate arm of the immune system...
  2. ncbi Genetics and beyond--the transcriptome of human monocytes and disease susceptibility
    Tanja Zeller
    Medizinische Klinik und Poliklinik, Johannes Gutenberg Universitat Mainz, Mainz, Germany
    PLoS ONE 5:e10693. 2010
    ....
  3. ncbi Activated monocytes in peritumoral stroma of hepatocellular carcinoma promote expansion of memory T helper 17 cells
    Dong Ming Kuang
    State Key Laboratory of Oncology in Southern China, Cancer Center, Guangzhou, P R China
    Hepatology 51:154-64. 2010
    ..Most peritumoral CD68(+) cells exhibited an activated phenotype. Accordingly, tumor-activated monocytes were significantly superior to the suppressive tumor macrophages in inducing expansion of Th17 cells from ..
  4. ncbi The chemokine system in diverse forms of macrophage activation and polarization
    Alberto Mantovani
    Centro di Eccellenza per l Innovazione Diagnostica e Terapeutica IDET, Institute of General Pathology, University of Milan, I 20133 Milan, Italy Istituto di Ricerche Farmacologiche Mario Negri, I 20157 Milan, Italy
    Trends Immunol 25:677-86. 2004
    ....
  5. ncbi SIVSM/HIV-2 Vpx proteins promote retroviral escape from a proteasome-dependent restriction pathway present in human dendritic cells
    Caroline Goujon
    LaboRetro, INSERM U758, Ecole Normale Superieure de Lyon, IFR 128 Biosciences Lyon Gerland, Lyon Biopole, France
    Retrovirology 4:2. 2007
    ..However, since the requirement for Vpx is specific for DCs and not for other non-dividing cell types, this suggests that Vpx may play a role other than nuclear import...
  6. ncbi The CD14+ CD16+ blood monocytes: their role in infection and inflammation
    Loems Ziegler-Heitbrock
    Department of Infection, Immunity and Inflammation, University of Leicester, Medical Sciences Building, University Road, Leicester, UK
    J Leukoc Biol 81:584-92. 2007
    Blood monocyte subpopulations have been defined in man initially, and the two major types of monocytes are the CD14++ CD16- and the CD14+ CD16+ monocytes...
  7. ncbi The identification of markers of macrophage differentiation in PMA-stimulated THP-1 cells and monocyte-derived macrophages
    Marc Daigneault
    Department of Infection and Immunity, Medical School, University of Sheffield, Sheffield, United Kingdom
    PLoS ONE 5:e8668. 2010
    ..cell line after various protocols of differentiation utilising VD(3) and PMA in comparison to primary human monocytes or monocyte-derived macrophages (MDM)...
  8. ncbi Human CD14dim monocytes patrol and sense nucleic acids and viruses via TLR7 and TLR8 receptors
    Jerome Cros
    U838 INSERM, Universite Paris Descartes, Paris, France
    Immunity 33:375-86. 2010
    b>Monocytes are effectors of the inflammatory response to microbes...
  9. ncbi Nomenclature of monocytes and dendritic cells in blood
    Loems Ziegler-Heitbrock
    Helmholtz Zentrum Munchen, Gauting, Germany
    Blood 116:e74-80. 2010
    b>Monocytes and cells of the dendritic cell lineage circulate in blood and eventually migrate into tissue where they further mature and serve various functions, most notably in immune defense...
  10. ncbi Microbial stimulation fully differentiates monocytes to DC-SIGN/CD209(+) dendritic cells for immune T cell areas
    Cheolho Cheong
    Chris Browne Center for Immunology and Immune Diseases, The Rockefeller University, New York, NY 10065, USA
    Cell 143:416-29. 2010
    ..critical antigen-presenting cells for immune control, normally derive from bone marrow precursors distinct from monocytes. It is not yet established if the large reservoir of monocytes can develop into cells with critical features of ..
  11. ncbi Apoptosis-associated speck-like protein (ASC) controls Legionella pneumophila infection in human monocytes
    Dalia H Abdelaziz
    Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Center for Microbial Interface Biology and the Department of Internal Medicine, Ohio State University, Columbus, Ohio 43210, USA
    J Biol Chem 286:3203-8. 2011
    ..pneumophila to cause pneumonia is determined by its capability to evade the immune system and grow within human monocytes and their derived macrophages...
  12. ncbi Monocyte chemoattractant protein-1 (MCP-1): an overview
    Satish L Deshmane
    Department of Neuroscience, Temple University School of Medicine, Philadelphia, PA 19140, USA
    J Interferon Cytokine Res 29:313-26. 2009
    ..Chemokines play a major role in selectively recruiting monocytes, neutrophils, and lymphocytes, as well as in inducing chemotaxis through the activation of G-protein-coupled ..
  13. ncbi Altered redox state of monocytes from cryopyrin-associated periodic syndromes causes accelerated IL-1beta secretion
    Sara Tassi
    Cell Biology Unit, National Cancer Research Institute, 16132 Genoa, Italy
    Proc Natl Acad Sci U S A 107:9789-94. 2010
    In healthy monocytes, Toll-like receptor (TLR) engagement induces production of reactive oxygen species (ROS), followed by an antioxidant response involved in IL-1beta processing and secretion...
  14. ncbi A cellular restriction dictates the permissivity of nondividing monocytes/macrophages to lentivirus and gammaretrovirus infection
    Rajnish Kaushik
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Cell Host Microbe 6:68-80. 2009
    ..We further demonstrate that this restriction prevents transduction of quiescent monocytes by HIV-1...
  15. ncbi Interaction of Vpx and apolipoprotein B mRNA-editing catalytic polypeptide 3 family member A (APOBEC3A) correlates with efficient lentivirus infection of monocytes
    Andre Berger
    Division of Medical Biotechnology, Paul Ehrlich Institut, 63225 Langen, Germany
    J Biol Chem 285:12248-54. 2010
    ..HIV-1, which does not encode Vpx, is not able to infect human monocytes, but Vpx enables infection with HIV-1. The underlying mechanism is not completely understood...
  16. ncbi Migrating monocytes recruited to the spleen play an important role in control of blood stage malaria
    Anne Marit Sponaas
    Division of Parasitology, Medical Research Council MRC National Institute for Medical Research, London, UK
    Blood 114:5522-31. 2009
    ..During Plasmodium chabaudi infection in mice, a population of CD11b(high)Ly6C(+) monocytes are generated in bone marrow, most of which depend on the chemokine receptor CCR2 for migration from bone marrow ..
  17. ncbi Differential requirement for the activation of the inflammasome for processing and release of IL-1beta in monocytes and macrophages
    Mihai G Netea
    Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, USA
    Blood 113:2324-35. 2009
    ..Here we demonstrate that human blood monocytes release processed IL-1beta after a one-time stimulation with either TLR2 or TLR4 ligands, resulting from ..
  18. ncbi Circulating monocytes from systemic sclerosis patients with interstitial lung disease show an enhanced profibrotic phenotype
    Susan K Mathai
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA
    Lab Invest 90:812-23. 2010
    Profibrotic cells derived from circulating CD14+ monocytes include fibrocytes and alternatively activated macrophages...
  19. ncbi CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis
    Bin Zhi Qian
    Department of Developmental and Molecular Biology, Center for the Study of Reproductive Biology and Women s Health, Albert Einstein College of Medicine, New York, New York 10461, USA
    Nature 475:222-5. 2011
    ..Here we define the origin of these macrophages by showing that Gr1-positive inflammatory monocytes are preferentially recruited to pulmonary metastases but not to primary mammary tumours in mice...
  20. ncbi Heat shock protein 90 and heat shock protein 70 are components of dengue virus receptor complex in human cells
    Jorge Reyes-Del Valle
    Departamento de Patologia Experimental, Centro de Investigacion y de Estudios Avanzados del IPN, Av I P N 2508, Col San Pedro Zacatenco, Mexico City D F, C P 07360, Mexico
    J Virol 79:4557-67. 2005
    ..Based on the ability of HSP90 (84 kDa) to interact with HSP70 (74 kDa) on the surface of monocytes during lipopolysaccharide (LPS) signaling and evidence that LPS inhibits dengue virus infection, the presence of ..
  21. ncbi Soluble cell adhesion molecules in monocytes of Alzheimer's disease and mild cognitive impairment
    Tanja Hochstrasser
    Department of General and Social Psychiatry, Innsbruck Medical University, Austria
    Exp Gerontol 45:70-4. 2010
    ..The microglial compartment may arise to a greater part from activation and transmigration of circulating monocytes. The aim of the present pilot study was to explore, if different cell adhesion molecules (ICAM-1 and -3, PECAM-1,..
  22. ncbi Induction and regulatory function of miR-9 in human monocytes and neutrophils exposed to proinflammatory signals
    Flavia Bazzoni
    Department of Pathology, Division of General Pathology, University of Verona, Strada Le Grazie 8, I 37134 Verona, Italy
    Proc Natl Acad Sci U S A 106:5282-7. 2009
    ..study, we characterize the profile of miRNAs induced by LPS in human polymorphonuclear neutrophils (PMN) and monocytes. In particular, we identify miR-9 as the only miRNA (among 365 analyzed) up-regulated in both cell types after ..
  23. ncbi Oxidized low-density and high-density lipoproteins regulate the production of matrix metalloproteinase-1 and -9 by activated monocytes
    Jeanette A Ardans
    Immunopathology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Leukoc Biol 71:1012-8. 2002
    b>Monocytes/macrophages are prominent in atherosclerotic plaques where the vascular remodeling and plaque rupture may be influenced by the lipids and cytokines at these sites...
  24. ncbi miR-198 inhibits HIV-1 gene expression and replication in monocytes and its mechanism of action appears to involve repression of cyclin T1
    Tzu Ling Sung
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS Pathog 5:e1000263. 2009
    ..Translation of Cyclin T1 mRNA has been shown to be repressed in human monocytes, and this repression is relieved when cells differentiate to macrophages...
  25. ncbi CD38 orchestrates migration, survival, and Th1 immune response of human mature dendritic cells
    Loredana Frasca
    Department of Infectious, Parasitic, and Immune Mediated Diseases, Istituto Superiore di Sanita, Rome, Italy
    Blood 107:2392-9. 2006
    ..These findings may lay out the basis to assess the functional role(s) of human CD38 in infections, autoimmune diseases, and neoplastic disorders...
  26. ncbi Ly6c+ "inflammatory monocytes" are microglial precursors recruited in a pathogenic manner in West Nile virus encephalitis
    Daniel R Getts
    The Discipline of Pathology, School of Medical Sciences, The University of Sydney, Sydney NSW 2006, Australia
    J Exp Med 205:2319-37. 2008
    ..Gr1(-)(Ly6C(lo))CX3CR1(+)) and "inflammatory" (Gr1(hi)/Ly6C(hi)/CCR2(+)) classical monocytes during infection abrogated the increase in microglia...
  27. ncbi High mobility group box 1 protein binding to lipopolysaccharide facilitates transfer of lipopolysaccharide to CD14 and enhances lipopolysaccharide-mediated TNF-alpha production in human monocytes
    Ju Ho Youn
    Department of Microbiology, Brain Korea 21 Project for Medical Science, National Core Research Center for Nanomedical Technology, Yonsei University College of Medicine, Seoul, Republic of Korea
    J Immunol 180:5067-74. 2008
    ..HMGB1 and LPS treatment results in a higher increase in TNF-alpha production in human PBMCs and peripheral blood monocytes than LPS or HMGB1 treatment alone or their summation...
  28. ncbi Vitamin D3 induces autophagy in human monocytes/macrophages via cathelicidin
    Jae Min Yuk
    Department of Microbiology, College of Medicine, Chungnam National University, Daejeon, Korea
    Cell Host Microbe 6:231-43. 2009
    ..We show that 1,25-dihydroxyvitamin D3 (1,25D3), the active form of vitamin D, induced autophagy in human monocytes via cathelicidin, which activated transcription of the autophagy-related genes Beclin-1 and Atg5...
  29. ncbi Comparison of gene expression profiles between human and mouse monocyte subsets
    Molly A Ingersoll
    Department of Gene and Cell Medicine and Immunology Institute, Mount Sinai School of Medicine, New York, NY, USA
    Blood 115:e10-9. 2010
    ..differences included a prominent peroxisome proliferator-activated receptor gamma (PPARgamma) signature in mouse monocytes, which is absent in humans, and strikingly opposed patterns of receptors involved in uptake of apoptotic cells ..
  30. ncbi Monocytes in atherosclerosis: subsets and functions
    Kevin J Woollard
    Center for Molecular and Cellular Biology of Inflammation CMCBI, Division of Immunology, Infection and Inflammatory Diseases DIIID, Guys Campus, London SE1 1UL, UK
    Nat Rev Cardiol 7:77-86. 2010
    ..Plaque macrophages account for the majority of leukocytes in plaques, and are believed to differentiate from monocytes recruited from circulating blood. However, monocytes represent a heterogenous circulating population of cells...
  31. ncbi Cerebral microglia recruit monocytes into the brain in response to tumor necrosis factoralpha signaling during peripheral organ inflammation
    Charlotte D'Mello
    Immunology Research Group, Department of Medicine, University of Calgary, Calgary, Alberta, Canada T2N 4N1
    J Neurosci 29:2089-102. 2009
    ..using a mouse model of inflammatory liver injury, we have confirmed the significant infiltration of activated monocytes into the brain in mice with hepatic inflammation and have defined the mechanism that mediates this trafficking ..
  32. ncbi Enolase-1 promotes plasminogen-mediated recruitment of monocytes to the acutely inflamed lung
    Malgorzata Wygrecka
    Department of Biochemistry, Faculty of Medicine, University of Giessen Lung Center, Giessen, Germany
    Blood 113:5588-98. 2009
    ..LPS)-driven chemokine-directed monocyte migration and matrix invasion in vitro, as well as recruitment of monocytes to the alveolar compartment in vivo...
  33. ncbi Programmed death-1-induced interleukin-10 production by monocytes impairs CD4+ T cell activation during HIV infection
    Elias A Said
    Centre de recherche du Centre hospitalier de l Université de Montréal CRCHUM, Hôpital St Luc, Montreal, Quebec, Canada
    Nat Med 16:452-9. 2010
    ..and inflammatory cytokines in the plasma of HIV-infected subjects lead to upregulation of PD-1 expression on monocytes that correlates with high plasma concentrations of IL-10...
  34. ncbi Type I interferon modulates monocyte recruitment and maturation in chronic inflammation
    Pui Y Lee
    Center for Autoimmune Disease, University of Florida, Gainesville, 32610 0221, USA
    Am J Pathol 175:2023-33. 2009
    Chronic inflammation is characterized by continuous recruitment and activation of immune cells such as monocytes in response to a persistent stimulus...
  35. ncbi Homogeneous monocytes and macrophages from human embryonic stem cells following coculture-free differentiation in M-CSF and IL-3
    Karl R Karlsson
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, UK
    Exp Hematol 36:1167-75. 2008
    To develop a simple and efficient method for producing homogeneous populations of monocytes and macrophages from human embryonic stem cells (hES).
  36. ncbi Adiponectin primes human monocytes into alternative anti-inflammatory M2 macrophages
    Fina Lovren
    Division of Cardiac Surgery, Keenan Research Centre in Li Ka Shing Knowledge Institute of St Michael s Hospital, Toronto, Ontario, Canada
    Am J Physiol Heart Circ Physiol 299:H656-63. 2010
    ..Because monocytes can differentiate into either proatherogenic M1 macrophages or anti-inflammatory M2 macrophages, approaches that ..
  37. ncbi Cyclic di-GMP signaling regulates invasion by Ehrlichia chaffeensis of human monocytes
    Yumi Kumagai
    Department of Veterinary Biosciences, The Ohio State University, Columbus, OH 43210, USA
    J Bacteriol 192:4122-33. 2010
    ..Furthermore, anti-HtrA inhibited CDGA-induced TRP120 degradation. Our results suggest that E. chaffeensis invasion is regulated by c-di-GMP signaling, which stabilizes some bacterial surface-exposed proteins against proteases...
  38. ncbi Monocytes from patients with type 1 diabetes spontaneously secrete proinflammatory cytokines inducing Th17 cells
    Elizabeth M Bradshaw
    Division of Molecular Immunology, Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 183:4432-9. 2009
    ..We examined the monocytes isolated directly from the blood of T1D patients and found they spontaneously secreted the proinflammatory ..
  39. ncbi Mycobacteria exploit p38 signaling to affect CD1 expression and lipid antigen presentation by human dendritic cells
    Maria Cristina Gagliardi
    Dipartimento di Malattie Infettive, Parassitarie e Immunomediate, Istituto Superiore di Sanita, Viale Regina Elena, 299, 00161 Roma, Italy
    Infect Immun 77:4947-52. 2009
    ..that Mycobacterium tuberculosis and bacillus Calmette-Guérin (Mycobacterium bovis BCG) induce human monocytes to differentiate into CD1- dendritic cells (DC), which cannot present lipid antigens to specific T cells...
  40. ncbi Quantitative expression of RIG-like helicase, NOD-like receptor and inflammasome-related mRNAs in humans and mice
    Maciej Lech
    Medizinische Poliklinik, University of Munich, 80336 Munich, Germany
    Int Immunol 22:717-28. 2010
    ..Resting human and mouse monocytes and T cells expressed most molecules and produced IL-1 beta and CCL5/RANTES upon activation...
  41. ncbi Activated monocytes in peritumoral stroma of hepatocellular carcinoma foster immune privilege and disease progression through PD-L1
    Dong Ming Kuang
    State Key Laboratory of Biocontrol, Sun Yat Sen University, Guangzhou 510 275, China
    J Exp Med 206:1327-37. 2009
    ..recently found that tumors can alter the normal developmental process of Mphi to trigger transient activation of monocytes in peritumoral stroma...
  42. ncbi HIV-1 transforms the monocyte plasma membrane proteome
    Irena Kadiu
    Department of Pharmacology and Experimental Neuroscience, Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, NE 68198 5880, USA
    Cell Immunol 258:44-58. 2009
    ..In contrast, PMA-treated monocytes bypassed caspase 3, 9 pathways and lead to cathepsin B-dependent necrosis...
  43. ncbi Sialoadhesin expressed on IFN-induced monocytes binds HIV-1 and enhances infectivity
    Hans Rempel
    Department of Laboratory Medicine at the Veterans Affairs Medical Center, San Francisco, California, United States of America
    PLoS ONE 3:e1967. 2008
    HIV-1 infection dysregulates the immune system and alters gene expression in circulating monocytes. Differential gene expression analysis of CD14(+) monocytes from subjects infected with HIV-1 revealed increased expression of ..
  44. ncbi Inhibition of bone and muscle metastases of lung cancer cells by a decrease in the number of monocytes/macrophages
    Koji Hiraoka
    Department of Orthopedic Surgery, Kurume University Schoool of Medicine, Kurume 830 0011, Japan
    Cancer Sci 99:1595-602. 2008
    ..In this study, we examined the effect of a decrease in the number of monocytes/macrophages in peripheral blood and the tumor stroma on the development of bone and muscle metastases by lung ..
  45. ncbi Coronary intraplaque hemorrhage evokes a novel atheroprotective macrophage phenotype
    Joseph J Boyle
    Vascular Sciences Section, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0NN, U K
    Am J Pathol 174:1097-108. 2009
    ..Differentiating monocytes with HbHp complexes reproduced the CD163(high) human leukocyte antigen-DR(low) HA-mac phenotype in vitro...
  46. ncbi A new pathway of staphylococcal pathogenesis: apoptosis-like death induced by Staphopain B in human neutrophils and monocytes
    Jan Smagur
    Department of Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland
    J Innate Immun 1:98-108. 2009
    Circulating neutrophils and monocytes form the first line of cellular defense against invading bacteria. Here, we describe a novel and specific mechanism of disabling and eliminating phagocytes by Staphylococcus aureus...
  47. ncbi Metalloproteinase expression in monocytes and macrophages and its relationship to atherosclerotic plaque instability
    Andrew C Newby
    Bristol Heart Institute, Bristol Royal Infirmary, Bristol BS2 8HW, UK
    Arterioscler Thromb Vasc Biol 28:2108-14. 2008
    ..Moreover, recent evidence suggests that different macrophage phenotypes express characteristically different spectra of MMPs and their inhibitors. New therapies may result from targeting matrix MMP overproduction...
  48. ncbi Monocytes contribute to the atherosclerotic cap by transformation into fibrocytes
    H J Medbury
    Vascular Biology Research Centre, Department of Surgery, University of Sydney, Westmead Hospital, Westmead, NSW, Australia
    Int Angiol 27:114-23. 2008
    ..Recent evidence suggests that circulating progenitors may be a source of these cells. We hypothesized that they may be fibrocytes bone-marrow derived cells that acquire SM-like characteristics, including the expression of SM alfa actin...
  49. ncbi Altered M1/M2 activation patterns of monocytes in severe relapsing experimental rat model of multiple sclerosis. Amelioration of clinical status by M2 activated monocyte administration
    Joanna Mikita
    University Victor Segalen, France
    Mult Scler 17:2-15. 2011
    We investigated proinflammatory M1 and immunomodulatory M2 activation profiles of circulating monocytes in relapsing experimental autoimmune encephalomyelitis (EAE) model of multiple sclerosis, and tested whether altered M1/M2 ..
  50. ncbi The myeloid-related proteins 8 and 14 complex, a novel ligand of toll-like receptor 4, and interleukin-1beta form a positive feedback mechanism in systemic-onset juvenile idiopathic arthritis
    Michael Frosch
    University of Muenster, Muenster, Germany
    Arthritis Rheum 60:883-91. 2009
    ..We undertook this study to analyze the relevance of myeloid-related proteins (MRPs) 8 and 14, endogenous activators of Toll-like receptor 4, in diagnosis and pathogenesis of systemic-onset JIA...
  51. ncbi Influence of bevacizumab, sunitinib and sorafenib as single agents or in combination on the inhibitory effects of VEGF on human dendritic cell differentiation from monocytes
    C Alfaro
    Gene Therapy and Hepatology Division, CIMA, Universidad de Navarra, Pamplona, Spain
    Br J Cancer 100:1111-9. 2009
    ..of renal carcinoma cell lines cultured under hypoxia were found to alter the differentiation of human monocytes to DC. Resulting DC showed impaired activity, as assessed by the alloreactive mixed T-lymphocyte reaction...
  52. ncbi Analyses of all matrix metalloproteinase members in leukocytes emphasize monocytes as major inflammatory mediators in multiple sclerosis
    Amit Bar-Or
    Montreal Neurological Institute, Quebec, Canada
    Brain 126:2738-49. 2003
    ..Of interest is the enrichment of a majority of MMP members in monocytes: MMP-1, MMP-3, MMP-9, MMP-10, MMP-14, MMP-19 and MMP-25...
  53. ncbi The phagocytes: neutrophils and monocytes
    David C Dale
    Department of Medicine, University of Washington School of Medicine, Seattle A98195, USA
    Blood 112:935-45. 2008
    ..demonstrated the high production rate and short lifespan of neutrophils and allowed researchers to follow the monocytes as they moved from the marrow through the blood to become tissue macrophages, histiocytes, and dendritic cells...
  54. ncbi Enhanced expression of cytokines and chemokines by blood monocytes to in vitro lipopolysaccharide stimulation are associated with hostility and severity of depressive symptoms in healthy women
    Edward C Suarez
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, P O Box 3328, Durham, NC 27710, USA
    Psychoneuroendocrinology 29:1119-28. 2004
    ..the relation of hostility and severity of depressive symptoms, separately and jointly, to the capacity of blood monocytes to secrete an array of cytokines when stimulated by bacterial lipopolysaccharide (LPS)...
  55. ncbi Activation of caspase-3 by the Dot/Icm virulence system is essential for arrested biogenesis of the Legionella-containing phagosome
    Maelle Molmeret
    Department of Microbiology and Immunology, University of Louisville College of Medicine, Louisville, KY 40292, USA
    Cell Microbiol 6:33-48. 2004
    ..Pretreatment of U937 macrophages and human peripheral blood monocytes (hPBM) with the capase-3 inhibitor (DEVD-fmk) or the paninhibitor of caspases (Z-VAD-fmk) before infection ..
  56. ncbi Myeloid differentiation and susceptibility to HIV-1 are linked to APOBEC3 expression
    Gang Peng
    Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892 4352, USA
    Blood 110:393-400. 2007
    ..By comparison, circulating CD4(+)CCR5(+) monocytes appear relatively resistant to HIV-1, and a fundamental unresolved question involves deciphering restriction ..
  57. ncbi Soluble CD276 (B7-H3) is released from monocytes, dendritic cells and activated T cells and is detectable in normal human serum
    Guangbo Zhang
    Clinical Immunology Laboratory, Suzhou University No 1 Affiliated Hospital, Suzhou, China
    Immunology 123:538-46. 2008
    Expression of membrane CD276 (mB7-H3) has been reported on dendritic cells (DCs), monocytes, activated T cells, and various carcinoma cells. However, reports concerning its in vivo function have been inconsistent...
  58. ncbi Increased monocyte turnover from bone marrow correlates with severity of SIV encephalitis and CD163 levels in plasma
    Tricia H Burdo
    Biology Department, Boston College, Chestnut Hill, Massachusetts, United States of America
    PLoS Pathog 6:e1000842. 2010
    ..b>Monocytes play critical roles in innate and adaptive immunity during inflammation...
  59. ncbi Phenotyping of peripheral blood mononuclear cells during acute dengue illness demonstrates infection and increased activation of monocytes in severe cases compared to classic dengue fever
    Anna P Durbin
    Johns Hopkins Bloomberg School of Public Health, 624 North Broadway, Room 251, Baltimore, MD 21205, USA
    Virology 376:429-35. 2008
    ..DEN prM was detected primarily in activated monocytes (CD14(+), CD32(+), CD86(+), CD11c(+))...
  60. ncbi C1q and mannose binding lectin engagement of cell surface calreticulin and CD91 initiates macropinocytosis and uptake of apoptotic cells
    C A Ogden
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Exp Med 194:781-95. 2001
    ....
  61. ncbi Identification of splenic reservoir monocytes and their deployment to inflammatory sites
    Filip K Swirski
    Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Science 325:612-6. 2009
    A current paradigm states that monocytes circulate freely and patrol blood vessels but differentiate irreversibly into dendritic cells (DCs) or macrophages upon tissue entry...
  62. ncbi Molecular cloning of human eotaxin, an eosinophil-selective CC chemokine, and identification of a specific eosinophil eotaxin receptor, CC chemokine receptor 3
    M Kitaura
    Shionogi Institute for Medical Science, Osaka, Japan
    J Biol Chem 271:7725-30. 1996
    ..produced in insect cells induced a calcium flux response in normal human eosinophils, but not in neutrophils or monocytes. The response could not be desensitized by pretreatment of eosinophils with other CC chemokines, suggesting a ..
  63. ncbi Expression of the serine protease inhibitor neuroserpin in cells of the human myeloid lineage
    Sarah A Kennedy
    School of Biological Sciences, Level 4, Thomas Building, University of Auckland, Private Bag 92019, Auckland 1010, New Zealand
    Thromb Haemost 97:394-9. 2007
    ..Neuroserpin was highly expressed and secreted following the differentiation of monocytes to macrophages and dendritic cells...
  64. ncbi VIP Inhibits Porphyromonas gingivalis LPS-induced immune responses in human monocytes
    N Foster
    Oral Microbiology and Host Responses Group, School of Dental Sciences, University of Newcastle upon Tyne, NE2 4BW, UK
    J Dent Res 84:999-1004. 2005
    ..This is the first report to show the potential of VIP as an immunomodulator of Pg-stimulated inflammatory pathways in human monocytes.
  65. ncbi Impaired dendritic cell differentiation and maturation in the absence of C3
    Edimara S Reis
    Departamento de Imunologia, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Av Professor Lineu Prestes 1730, 05508 900 Sao Paulo, SP, Brazil
    Mol Immunol 45:1952-62. 2008
    Human monocytes can be differentiated into immature dendritic cells (DCs) in the presence of serum and cytokines. One of the main functions of immature DCs is to capture and process antigens...
  66. ncbi Activation of rainbow trout (Oncorhynchus mykiss) mononuclear phagocytes by different pathogen associated molecular pattern (PAMP) bearing agents
    Dimitar B Iliev
    Great Lakes WATER Institute, University of Wisconsin Milwaukee, 600 E. Greenfield Ave, Milwaukee, WI 53204, USA
    Mol Immunol 42:1215-23. 2005
    ..By analogy to the type of stimulation observed in mammals it can be hypothesized that different signaling pathways, possibly initiated by different receptors, may be involved in the recognition of these PAMPs by rtMOCs...
  67. ncbi Differential activation of dendritic cells by nerve growth factor and brain-derived neurotrophic factor
    O Noga
    Department of Infectious and Respiratory Diseases Charité, Universitatsmedizin Berlin, Berlin, Germany
    Clin Exp Allergy 37:1701-8. 2007
    ..Dendritic cells (DCs) play a major role in the induction of inflammatory processes with an increasing role in allergic diseases as well...
  68. ncbi Cytokine profiles of canine monocyte-derived dendritic cells as a function of lipopolysaccharide- or tumor necrosis factor-alpha-induced maturation
    Yu Shan Wang
    Animal Cancer Research Center, Department of Veterinary Medicine, National Taiwan University, 1 Roosevelt Road, Section 4, Taipei 106, Taiwan, ROC
    Vet Immunol Immunopathol 118:186-98. 2007
    ..Thus, canine DC maturing from different stimuli release different cytokine profiles that in turn promote different immune responses and activate innate and adaptive immune responses...
  69. ncbi LAG-3 (CD223) reduces macrophage and dendritic cell differentiation from monocyte precursors
    Sandrine Buisson
    , , , France
    Immunology 114:369-74. 2005
    Major histocompatibility complex (MHC) class II molecules expressed on monocytes may play a role in the control of differentiation of antigen-presenting cells...
  70. ncbi Airway epithelial cells modify immune responses by inducing an anti-inflammatory microenvironment
    Anja K Mayer
    Department of Hygiene and Medical Microbiology, University Heidelberg, Heidelberg, Germany
    Eur J Immunol 38:1689-99. 2008
    ..BEAS-2B bronchial epithelial cells inhibited secretion of the pro-inflammatory cytokines TNF-alpha and IL-12 by monocytes, macrophages and dendritic cells...
  71. ncbi Inorganic arsenite alters macrophage generation from human peripheral blood monocytes
    Teruaki Sakurai
    Laboratory of Environmental Chemistry, School of Life Science, Tokyo University of Pharmacy and Life Science, Horinouchi, Hachioji, Tokyo 192 0392, Japan
    Toxicol Appl Pharmacol 203:145-53. 2005
    ..arsenite at nanomolar concentrations on the in vitro differentiation of human macrophages from peripheral blood monocytes. While arsenite was found to induce cell death in a culture system containing macrophage colony stimulating ..
  72. ncbi LPS-induced up-regulation of TGF-beta receptor 1 is associated with TNF-alpha expression in human monocyte-derived macrophages
    Yan Chen
    Division of Paediatric Surgery, Department of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, China
    J Leukoc Biol 83:1165-73. 2008
    ..SB431542 had similar inhibitory effects on TNF-alpha production by human monocytes and endothelial cells as well as macrophages...
  73. ncbi Calcium/calmodulin-dependent kinase II is required for platelet-activating factor priming
    Joseph Cuschieri
    Department of Surgery, University of Washington, Seattle, WA 98104, USA
    Shock 23:99-106. 2005
    ..This priming event is mediated in part by modulation of ERK 1/2, JNK/SAPK, NF-kappaB, and AP-1 activation. CaMK IV, on the other hand, is not specific for priming by PAF and appears to have a direct link in TLR4-mediated events...
  74. ncbi LPS-induced ROS generation and changes in glutathione level and their relation to the maturation of human monocyte-derived dendritic cells
    Hiroko Yamada
    Department of Hematology and Oncology, Kyoto University Hospital, Kyoto 606-8507, Japan
    Life Sci 78:926-33. 2006
    ....
  75. ncbi Impaired maturation of monocyte-derived dendritic cells from birch allergic individuals in association with birch-specific immune responses
    R Casas
    Division of Paediatrics, Department of Molecular and Clinical Medicine, Faculty of Health Science, University of Linkoping, Linkoping, Sweden
    Scand J Immunol 66:591-8. 2007
    ..We investigated whether DC differentiated from monocytes from healthy and birch allergic asthmatic individuals and further maturated by stimulation with cat and birch ..
  76. ncbi Echinococcus granulosus antigen B impairs human dendritic cell differentiation and polarizes immature dendritic cell maturation towards a Th2 cell response
    Rachele Riganò
    Dipartimento di Malattie Infettive, Parassitarie ed Immunomediate, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    Infect Immun 75:1667-78. 2007
    ..granulosus-stimulated DC maturation. These results suggest that E. granulosus escapes host immunosurveillance in two ways: by interfering with monocyte differentiation and by modulating DC maturation...
  77. ncbi CCL20 production is induced in human dental pulp upon stimulation by Streptococcus mutans and proinflammatory cytokines
    K Takahashi
    Department of Conservative Dentistry, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Tokushima, Japan
    Oral Microbiol Immunol 23:320-7. 2008
    ..However, the mechanism of CCL20 expression remains unclear...
  78. ncbi Neisseria meningitidis type C capsular polysaccharide inhibits lipooligosaccharide-induced cell activation by binding to CD14
    Can Kocabas
    Laboratory of Bacterial Polysaccharides, Center for Biologics Evaluation and Research, U S Food and Drug Administration, 1410 Rockville Pike HFM 428, Rockville, MD 20852 1448, USA
    Cell Microbiol 9:1297-310. 2007
    ..meningitidis (MCPS) inhibited LOS-induced interleukin-6 and TNF-alpha secretion from monocytes, and blocked the maturation of dendritic cells induced by LOS, while the capsular polysaccharide from group B ..
  79. ncbi Differentiation of human monocytes in vitro following exposure to Canova in the absence of cytokines
    Eureke Smit
    Department of Anatomy, School of Medicine, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa
    Ultrastruct Pathol 32:147-52. 2008
    ..Since monocytes are the precursor cells of macrophages and dendritic cells, the objective of the current study was to ..
  80. ncbi Cadexomer as well as cadexomer iodine induces the production of proinflammatory cytokines and vascular endothelial growth factor by human macrophages
    Tomoyuki Ohtani
    Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Exp Dermatol 16:318-23. 2007
    ..Human macrophages were obtained by culturing CD14+ monocytes with macrophage colony stimulating factor (M-CSF) in the presence or absence of cadexomer or cadexomer iodine...
  81. ncbi Monocyte-derived dendritic cell function in chronic hepatitis C is impaired at physiological numbers of dendritic cells
    A J MacDonald
    iQur Ltd, Southampton General Hospital, Southampton, UK
    Clin Exp Immunol 148:494-500. 2007
    ..Because the functional defect was not apparent at high MoDC : T cell ratios, autologous MoDC therapy with sufficiently high numbers of DCs could, in theory, overcome any impairment of MoDC function in CHC...
  82. ncbi Expression of the alternative reading frame protein of Hepatitis C virus induces cytokines involved in hepatic injuries
    Marc Fiorucci
    FRE 2736 CNRS bioMérieux, IFR 128 Biosciences Lyon Gerland, Lyon, France
    J Gen Virol 88:1149-62. 2007
    ..This study was designed to evaluate the immunomodulatory functions of Core and ARFPs in monocytes, dendritic cells (DCs), macrophages (Mphi) and hepatocytes, cells that are all capable of supporting HCV ..
  83. ncbi alpha1-Antitrypsin regulates CD14 expression and soluble CD14 levels in human monocytes in vitro
    Izabela M Nita
    Department of Clinical Sciences, Wallenberg Laboratory, University Hospital Malmo, Lund University, SE 20502 Malmo, Sweden
    Int J Biochem Cell Biol 39:1165-76. 2007
    ..In contrast, longer term incubation (18 h) of monocytes with combined AAT/LPS results in a significant reduction in expression of both CD14 and TLR4, inhibition of LPS-..
  84. ncbi Mixed Langerhans cell and interstitial/dermal dendritic cell subsets emanating from monocytes in Th2-mediated inflammatory conditions respond differently to proinflammatory stimuli
    Nicolas Bechetoille
    INSERM Unit 346, Human Skin and Immunity, EA No. 37-32, Claude Bernard University Lyon 1, Edouard Herriot Hospital, 69437 Lyon Cedex 03, France
    J Leukoc Biol 80:45-58. 2006
    ..To demonstrate that monocytes may act as DC precursors for skin DC in postinflammatory recolonization, we generated LC and IDDC from monocytes ..
  85. ncbi Lactoferrin acts as an alarmin to promote the recruitment and activation of APCs and antigen-specific immune responses
    Gonzalo de la Rosa
    Laboratory of Molecular Immunoregulation, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, Fredrick, MD 21702, USA
    J Immunol 180:6868-76. 2008
    ..In this study, we show the ability of recombinant human lactoferrin (talactoferrin alfa (TLF)) to chemoattract monocytes. What is more, addition of TLF to human peripheral blood or monocyte-derived dendritic cell cultures resulted in ..
  86. ncbi Chloroquine inhibits production of TNF-alpha, IL-1beta and IL-6 from lipopolysaccharide-stimulated human monocytes/macrophages by different modes
    C-H Jang
    Department of Biochemistry, College of Medicine, Catholic University of Korea, 505 Banpo-dong, Seocho-gu, Seoul 137-701, South Korea
    Rheumatology (Oxford) 45:703-10. 2006
    ..METHODS: Human peripheral blood mononuclear cells and monocytes/macrophages and monocytic U-937 and THP-1 cells were stimulated with lipopolysaccharide, and TNF-alpha, IL-1beta ..
  87. ncbi TNF-alpha drives human CD14+ monocytes to differentiate into CD70+ dendritic cells evoking Th1 and Th17 responses
    Sanju Iwamoto
    Department of Biochemistry, School of Medicine, Showa University, Tokyo, Japan
    J Immunol 179:1449-57. 2007
    ..CD14(+) monocytes cultured in the presence of TNF-alpha and GM-CSF converted to CD14(+) CD1a(low) adherent cells with little ..
  88. ncbi Characterization of canine monocyte-derived dendritic cells with phenotypic and functional differentiation
    Yu Shan Wang
    Department of Veterinary Medicine, National Taiwan University
    Can J Vet Res 71:165-74. 2007
    ..The plasma enriched the population of CD14-positive monocytes by greatly enhancing the efficiency of monocyte adherence, the proportion of adherent cells increasing from 6...
  89. ncbi The cachectic mediator proteolysis inducing factor activates NF-kappaB and STAT3 in human Kupffer cells and monocytes
    Tammy M Watchorn
    Tissue Injury and Repair Group, Cell Injury and Apoptosis Section, Centre for Inflammation Research, University of Edinburgh, Edinburgh, UK
    Int J Oncol 27:1105-11. 2005
    ..able to activate pro-inflammatory pathways in human Kupffer cells, the resident macrophages of the liver, and in monocytes, resulting in the production of pro-inflammatory cytokines...
  90. ncbi Human ribonuclease A superfamily members, eosinophil-derived neurotoxin and pancreatic ribonuclease, induce dendritic cell maturation and activation
    De Yang
    Basic Research Program, Science Applications International Corporation SAIC Frederick, MD 21702, USA
    J Immunol 173:6134-42. 2004
    ..We therefore propose these mediators be considered as endogenous multifunctional immune alarmins...
  91. ncbi Inducible expression of PTX3, a new member of the pentraxin family, in human mononuclear phagocytes
    V V Alles
    Laboratory of Immunology, Istituto di Ricerche Farmacologiche, Mario Negri, Milano, Italy
    Blood 84:3483-93. 1994
    ..Among leukocytes, only monocytes exposed to inflammatory cytokines or LPS expressed the PTX3 transcript, which was undetectable in resting or ..
  92. ncbi TNF skews monocyte differentiation from macrophages to dendritic cells
    Pascale Chomarat
    Baylor Institute for Immunology Research, 3434 Live Oak, Dallas, TX 75204, USA
    J Immunol 171:2262-9. 2003
    b>Monocytes represent a large pool of circulating precursors of APCs, both macrophages and dendritic cells (DCs). It is thus important to identify the mechanisms by which microenvironment regulates monocyte differentiation...
  93. ncbi Heterogeneous requirement of IkappaB kinase 2 for inflammatory cytokine and matrix metalloproteinase production in rheumatoid arthritis: implications for therapy
    Evangelos Andreakos
    Kennedy Institute of Rheumatology, Imperial College of Science, Technology and Medicine, London, UK
    Arthritis Rheum 48:1901-12. 2003
    ....
  94. ncbi Leishmania (Leishmania) chagasi infection alters the expression of cell adhesion and costimulatory molecules on human monocyte and macrophage
    M C De Almeida
    Faculdade de Medicina, Universidade Federal da Bahia Gonçalo Moniz, FIOCRUZ, Salvador, BA, Brazil
    Int J Parasitol 33:153-62. 2003
    ..There is limited information on the Leishmania infected human monocytes, the first cells that the parasite lives in, particularly related to costimulatory molecules...
  95. ncbi Inhibition of endotoxin response by e5564, a novel Toll-like receptor 4-directed endotoxin antagonist
    Maureen Mullarkey
    Biology Section, Eisai Research Institute of Boston, Inc, Andover, Massachusetts, USA
    J Pharmacol Exp Ther 304:1093-102. 2003
    ..These results indicate that E5564 is a potent antagonist of LPS and lacks agonistic activity in human and animal model systems, making it a potentially effective therapeutic agent for treatment of disease states caused by endotoxin...
  96. ncbi Pertussis toxin and the adenylate cyclase toxin from Bordetella pertussis activate human monocyte-derived dendritic cells and dominantly inhibit cytokine production through a cAMP-dependent pathway
    Kenneth C Bagley
    Division of Vaccine Research, Institute of Human Virology, University of Maryland Biotechnology Institute, and Department of Microbiology, University of Maryland School of Medicine, Baltimore 21201, USA
    J Leukoc Biol 72:962-9. 2002
    ..Also, cAMP-dependent kinase inhibitors blocked the ability of PT, AT, d-cAMP, and Forskolin to activate MDDC. Taken together, these results show that the effects of PT and AT on MDDC are mediated strictly by cAMP...
  97. ncbi Activation of terminally differentiated human monocytes/macrophages by dengue virus: productive infection, hierarchical production of innate cytokines and chemokines, and the synergistic effect of lipopolysaccharide
    Yun Chi Chen
    Laboratory of Hematology, Department of Medical Research and Education, Veterans General Hospital Taipei, Taipei, Taiwan, Republic of China
    J Virol 76:9877-87. 2002
    Dengue virus (DV) primarily infects blood monocytes (MO) and tissue macrophages (M phi). We have shown in the present study that DV can productively infect primary human MO/M phi regardless of the stage of cell differentiation...
  98. ncbi The sesquiterpene lactone parthenolide inhibits LPS- but not TNF-alpha-induced maturation of human monocyte-derived dendritic cells by inhibition of the p38 mitogen-activated protein kinase pathway
    Hiroshi Uchi
    Division of Immunology and Allergology, University of Geneva, Geneva, Switzerland
    J Allergy Clin Immunol 110:269-76. 2002
    ..Dendritic cells (DCs) are the most potent antigen-presenting cells, and the manipulation of DC maturation provides a strategy for the treatment of allergic and inflammatory diseases...
  99. ncbi The human EGF-TM7 family member EMR2 is a heterodimeric receptor expressed on myeloid cells
    Mark J Kwakkenbos
    Laboratory for Experimental Immunology, Academic Medical Center, University of Amsterdam, The Netherlands
    J Leukoc Biol 71:854-62. 2002
    ..Highest expression levels were detected on the more mature CD16(+) blood monocytes, on macrophages, and on BDCA-3(+) myeloid DC, whereas little if any expression was found on granulocytes...
  100. ncbi Tumor-associated macrophages as a source of functional dendritic cells in ovarian cancer patients
    Christina S Chu
    Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Clin Immunol 102:291-301. 2002
    ..Therefore, TAMs have potential use for either ex vivo or in vivo DC-based immunotherapy, particularly in individuals in which more conventional sources of DCs have been depleted...
  101. ncbi Adenovirus type 5 vectors induce dendritic cell differentiation in human CD14(+) monocytes cultured under serum-free conditions
    Lyudmila A Lyakh
    Regulation of Cell Growth Laboratory, The Laboratory of Experimental Immunology, and the Mouse Cancer Genetics Program, National Cancer Institute at Frederick, MD 21702-1201, USA
    Blood 99:600-8. 2002
    ..by a model virus is capable of initiating dendritic cell (DC) differentiation, human CD14(+) peripheral blood monocytes were infected with replication-defective type 5 adenovirus...

Research Grants89

  1. THE CHEMOKINE RECEPTOR CXCR-2 IN ATHEROSCLEROSIS
    William Boisvert; Fiscal Year: 2002
    ..First they will determine if retention of lesion monocytes is greater in LDLR-/-, mIL-8RH+/+ than LDLR-/-, mIL-8RH-/- mice...
  2. REGULATION OF INDUCIBLE GENE EXPRESSION IN MONOCYTES
    Nigel Mackman; Fiscal Year: 2007
    ..Lipopolysaccharide (LPS [endotoxin]) from Gram-negative bacteria induces monocytes and endothelial cells to express the procoagulant protein tissue factor (TF), which initiates disseminated ..
  3. HO-1 and granuloma formation in TB pleurisy
    Veena B Antony; Fiscal Year: 2010
    ..b>Monocytes are recruited to the site of tuberculous infection by the interaction of C-C chemokines, (mainly monocyte ..
  4. ADENINE DEOXYNUCLEOTIDE METABOLISM AND IMMUNE FUNCTION
    Dennis Carson; Fiscal Year: 1993
    Lymphocytes and monocytes are critical cells in the pathogenesis of immunodeficiency, autoimmune, and certain malignant diseases...
  5. MONOCYTE ADHESION TO ATHEROMA IN GENE TARGETED MICE
    Klaus Ley; Fiscal Year: 2000
    ..An important component of atherosclerotic lesions is the presence of foam cells derived from blood monocytes which infiltrate the vessel wall at an early stage of lesion development...
  6. EMAP II, a molecular link of inflammation and apoptosis in pulmonary emphysema.
    Irina Petrache; Fiscal Year: 2010
    ..effect of EMAP II on endothelial cells, coupled with its ability to activate and recruit pro-inflammatory monocytes, we hypothesize that excessive EMAP II release in response to cigarette smoking engages both lung endothelial ..
  7. EMAP II, a molecular link of inflammation and apoptosis in pulmonary emphysema.
    Matthias Clauss; Fiscal Year: 2009
    ..effect of EMAP II on endothelial cells, coupled with its ability to activate and recruit pro-inflammatory monocytes, we hypothesize that excessive EMAP II release in response to cigarette smoking engages both lung endothelial ..
  8. HDL Modulation of monocyte function in endotoxemia
    C Roger White; Fiscal Year: 2010
    ..Under inflammatory conditions, monocytes infiltrate the artery wall and differentiate to either dendritic cells (DCs) or macrophages (MF)...
  9. HDL Modulation of monocyte function in endotoxemia
    Geeta Datta; Fiscal Year: 2009
    ..Under inflammatory conditions, monocytes infiltrate the artery wall and differentiate to either dendritic cells (DCs) or macrophages (MF)...
  10. HDL Modulation of monocyte function in endotoxemia
    Geeta Datta; Fiscal Year: 2009
    ..Under inflammatory conditions, monocytes infiltrate the artery wall and differentiate to either dendritic cells (DCs) or macrophages (MF)...
  11. ETHANOLS ROLE MEDIATION OF MONOCYTE IMMUNOSUPPRESSION
    Gyongyi Szabo; Fiscal Year: 2003
    ..These experiments will define monocyte alterations leading to the combined immunosuppressive effects of in vivo ethanol uptake and trauma. ..
  12. REGULATION OF INDUCIBLE GENE EXPRESSION IN MONOCYTES
    Nigel Mackman; Fiscal Year: 2009
    ..Lipopolysaccharide (LPS [endotoxin]) from Gram-negative bacteria induces monocytes and endothelial cells to express the procoagulant protein tissue factor (TF), which initiates disseminated ..
  13. Differentiation/migratory fate of monocyte-derived cells
    Gwendalyn J Randolph; Fiscal Year: 2010
    ..Indeed, no information is available on whether the two major subsets of monocytes are cleared from sites of inflammation by different mechanisms...
  14. MONOCYTE RECRUITMENT IN PLEUROPULMONARY TB IN AIDS
    Veena Antony; Fiscal Year: 2005
    ..b>Monocytes are recruited to the site of tuberculous infection by the interaction of C-C chemokines, (mainly monocyte ..
  15. METALLOTHIONEIN, MERCURY AND MONOCYTE ACTIVATION
    RUDOLFS ZALUPS; Fiscal Year: 2006
    ..Activation is the acute phase response and respiratory burst undergone by monocytes (and other leukocytes) as a response to extracellular events and signals...
  16. Monocyte Modulation in LAgP
    SUZANNE BARBOUR; Fiscal Year: 2005
    ..Several lines of evidence suggest that LAgP monocytes exhibit a unique phenotype...
  17. Lung Endothelial Barrier Function and its Deregulation by Sickle Erythrocytes
    Solomon Ofori Acquah; Fiscal Year: 2007
    ..cells fulfill a central role in the response to inflammation by controlling the number of circulating monocytes recruited to interstitial tissue compartments...
  18. Monocyte Adhesion to Atheroma in Gene Targeted
    Klaus Ley; Fiscal Year: 2005
    Atherosclerosis is considered an inflammatory disease triggered by the entry of monocytes into the wall of large arteries, where they differentiate into macrophages and foam cells and promote growth and dedifferentiation of smooth ..
  19. Monocyte activation and the role of CD11c in obesity-linked metabolic syndrome
    Huaizhu Wu; Fiscal Year: 2010
    ..CD11c is a b2 integrin primarily expressed on monocytes/macrophages and dendritic cells (DCs) that is a marker for monocyte/macrophage activation and participates in ..
  20. TRANSGENIC MICE, INFLAMMATION & THE ALZHEIMER PHENOTYPE
    Marcia N Gordon; Fiscal Year: 2010
    ..As an alternative delivery method, we propose to evaluate the use of monocytes, cells normally found in blood, as vectors to transport therapeutic genes to the brain...
  21. Monocyte Adhesive Hyaluronan Structures in Diabetes
    Aimin Wang; Fiscal Year: 2007
    ..and proliferation of the glomerular mesangial cells, followed by a prominent glomerular infiltration of monocytes and macrophages...
  22. Dopamine alters CNS migration of uninfected and HIV infected leukocytes to SDF-1
    JOAN WEINBERGER BERMAN; Fiscal Year: 2010
    ..Some studies have found that drug abuse increases the number of T lymphocytes and monocytes that enter the brain during HIV infection when compared to infected individuals without a history of drug abuse ..
  23. Dopamine alters CNS migration of uninfected and HIV infected leukocytes to SDF-1
    JOAN BERMAN; Fiscal Year: 2009
    ..Some studies have found that drug abuse increases the number of T lymphocytes and monocytes that enter the brain during HIV infection when compared to infected individuals without a history of drug abuse ..
  24. Monocyte Pathogenesis: Regulation of NADPH Oxidase
    MARTHA CATHCART; Fiscal Year: 2007
    The production of superoxide anion (02-) by activated monocytes and neutrophils is an essential element of host defense and inflammation. 02- is generated via the enzyme complex, NADPH oxidase...