monocytes

Summary

Summary: Large, phagocytic mononuclear leukocytes produced in the vertebrate BONE MARROW and released into the BLOOD; contain a large, oval or somewhat indented nucleus surrounded by voluminous cytoplasm and numerous organelles.

Top Publications

  1. pmc Development of monocytes, macrophages, and dendritic cells
    Frederic Geissmann
    Centre for Molecular and Cellular Biology of Inflammation, Division of Immunology, Infection, and Inflammatory Diseases, King s College London, Great Maze Pond, London SE1 1UL, UK
    Science 327:656-61. 2010
  2. ncbi Monocyte and macrophage heterogeneity
    Siamon Gordon
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
    Nat Rev Immunol 5:953-64. 2005
  3. pmc Genetics and beyond--the transcriptome of human monocytes and disease susceptibility
    Tanja Zeller
    Medizinische Klinik und Poliklinik, Johannes Gutenberg Universitat Mainz, Mainz, Germany
    PLoS ONE 5:e10693. 2010
  4. doi Monocyte recruitment during infection and inflammation
    Chao Shi
    Infectious Diseases Service, Department of Medicine, Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, USA
    Nat Rev Immunol 11:762-74. 2011
  5. pmc Monocyte chemoattractant protein-1 (MCP-1): an overview
    Satish L Deshmane
    Department of Neuroscience, Temple University School of Medicine, Philadelphia, PA 19140, USA
    J Interferon Cytokine Res 29:313-26. 2009
  6. doi Nomenclature of monocytes and dendritic cells in blood
    Loems Ziegler-Heitbrock
    Helmholtz Zentrum Munchen, Gauting, Germany
    Blood 116:e74-80. 2010
  7. pmc CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis
    Bin Zhi Qian
    Department of Developmental and Molecular Biology, Center for the Study of Reproductive Biology and Women s Health, Albert Einstein College of Medicine, New York, New York 10461, USA
    Nature 475:222-5. 2011
  8. pmc Identification of splenic reservoir monocytes and their deployment to inflammatory sites
    Filip K Swirski
    Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Science 325:612-6. 2009
  9. ncbi Monitoring of blood vessels and tissues by a population of monocytes with patrolling behavior
    Cedric Auffray
    Institut Nationale de la Santé et de la Recherche Médicale INSERM U838, Laboratory of Biology of the Mononuclear Phagocyte System, and Cellular and Molecular imaging core facility, Institut Federatif de Recherche Necker Enfants Malades, Paris, France
    Science 317:666-70. 2007
  10. pmc Microbial stimulation fully differentiates monocytes to DC-SIGN/CD209(+) dendritic cells for immune T cell areas
    Cheolho Cheong
    Chris Browne Center for Immunology and Immune Diseases, The Rockefeller University, New York, NY 10065, USA
    Cell 143:416-29. 2010

Detail Information

Publications256 found, 100 shown here

  1. pmc Development of monocytes, macrophages, and dendritic cells
    Frederic Geissmann
    Centre for Molecular and Cellular Biology of Inflammation, Division of Immunology, Infection, and Inflammatory Diseases, King s College London, Great Maze Pond, London SE1 1UL, UK
    Science 327:656-61. 2010
    b>Monocytes and macrophages are critical effectors and regulators of inflammation and the innate immune response, the immediate arm of the immune system...
  2. ncbi Monocyte and macrophage heterogeneity
    Siamon Gordon
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
    Nat Rev Immunol 5:953-64. 2005
    ..Circulating monocytes give rise to mature macrophages and are also heterogeneous themselves, although the physiological relevance of ..
  3. pmc Genetics and beyond--the transcriptome of human monocytes and disease susceptibility
    Tanja Zeller
    Medizinische Klinik und Poliklinik, Johannes Gutenberg Universitat Mainz, Mainz, Germany
    PLoS ONE 5:e10693. 2010
    ....
  4. doi Monocyte recruitment during infection and inflammation
    Chao Shi
    Infectious Diseases Service, Department of Medicine, Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, USA
    Nat Rev Immunol 11:762-74. 2011
    b>Monocytes originate from progenitors in the bone marrow and traffic via the bloodstream to peripheral tissues...
  5. pmc Monocyte chemoattractant protein-1 (MCP-1): an overview
    Satish L Deshmane
    Department of Neuroscience, Temple University School of Medicine, Philadelphia, PA 19140, USA
    J Interferon Cytokine Res 29:313-26. 2009
    ..Chemokines play a major role in selectively recruiting monocytes, neutrophils, and lymphocytes, as well as in inducing chemotaxis through the activation of G-protein-coupled ..
  6. doi Nomenclature of monocytes and dendritic cells in blood
    Loems Ziegler-Heitbrock
    Helmholtz Zentrum Munchen, Gauting, Germany
    Blood 116:e74-80. 2010
    b>Monocytes and cells of the dendritic cell lineage circulate in blood and eventually migrate into tissue where they further mature and serve various functions, most notably in immune defense...
  7. pmc CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis
    Bin Zhi Qian
    Department of Developmental and Molecular Biology, Center for the Study of Reproductive Biology and Women s Health, Albert Einstein College of Medicine, New York, New York 10461, USA
    Nature 475:222-5. 2011
    ..Here we define the origin of these macrophages by showing that Gr1-positive inflammatory monocytes are preferentially recruited to pulmonary metastases but not to primary mammary tumours in mice...
  8. pmc Identification of splenic reservoir monocytes and their deployment to inflammatory sites
    Filip K Swirski
    Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Science 325:612-6. 2009
    A current paradigm states that monocytes circulate freely and patrol blood vessels but differentiate irreversibly into dendritic cells (DCs) or macrophages upon tissue entry...
  9. ncbi Monitoring of blood vessels and tissues by a population of monocytes with patrolling behavior
    Cedric Auffray
    Institut Nationale de la Santé et de la Recherche Médicale INSERM U838, Laboratory of Biology of the Mononuclear Phagocyte System, and Cellular and Molecular imaging core facility, Institut Federatif de Recherche Necker Enfants Malades, Paris, France
    Science 317:666-70. 2007
    ..We have shown, by direct examination of blood monocyte functions in vivo, that a subset of monocytes patrols healthy tissues through long-range crawling on the resting endothelium...
  10. pmc Microbial stimulation fully differentiates monocytes to DC-SIGN/CD209(+) dendritic cells for immune T cell areas
    Cheolho Cheong
    Chris Browne Center for Immunology and Immune Diseases, The Rockefeller University, New York, NY 10065, USA
    Cell 143:416-29. 2010
    ..critical antigen-presenting cells for immune control, normally derive from bone marrow precursors distinct from monocytes. It is not yet established if the large reservoir of monocytes can develop into cells with critical features of ..
  11. ncbi Transcriptional profiling of the human monocyte-to-macrophage differentiation and polarization: new molecules and patterns of gene expression
    Fernando O Martinez
    Istituto Clinico Humanitas, Rozzano, Italy
    J Immunol 177:7303-11. 2006
    ..is associated with activation of cell cycle genes, substantiating the underestimated proliferation potential of monocytes. 2) M-CSF leads to expression of a substantial part of the M2 transcriptome, suggesting that under homeostatic ..
  12. pmc In vivo analysis of dendritic cell development and homeostasis
    Kang Liu
    Laboratory of Molecular Immunology, Rockefeller University, New York, NY 10065, USA
    Science 324:392-7. 2009
    Dendritic cells (DCs) in lymphoid tissue arise from precursors that also produce monocytes and plasmacytoid DCs (pDCs)...
  13. pmc Monocyte-mediated defense against microbial pathogens
    Natalya V Serbina
    Infectious Diseases Service, Department of Medicine, Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Annu Rev Immunol 26:421-52. 2008
    Circulating blood monocytes supply peripheral tissues with macrophage and dendritic cell (DC) precursors and, in the setting of infection, also contribute directly to immune defense against microbial pathogens...
  14. ncbi Quantitative expression of toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides
    Veit Hornung
    Department of Internal Medicine, Division of Clinical Pharmacology, University of Munich, Munich, Germany
    J Immunol 168:4531-7. 2002
    ..High expression of TLR2 was characteristic for monocytes. PDC and B cells expressed marked levels of TLR7 and TLR9 and were directly sensitive to CpG ODN...
  15. pmc Monocyte subsets differentially employ CCR2, CCR5, and CX3CR1 to accumulate within atherosclerotic plaques
    Frank Tacke
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Clin Invest 117:185-94. 2007
    b>Monocytes participate critically in atherosclerosis. There are 2 major subsets expressing different chemokine receptor patterns: CCR2(+)CX3CR1(+)Ly-6C(hi) and CCR2(-)CX3CR1(++)Ly-6C(lo) monocytes...
  16. pmc Human IL-23-producing type 1 macrophages promote but IL-10-producing type 2 macrophages subvert immunity to (myco)bacteria
    Frank A W Verreck
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Centre, Albinusdreef 2, NL 2333 ZA, Leiden, The Netherlands
    Proc Natl Acad Sci U S A 101:4560-5. 2004
    ..Mphi heterogeneity thus may be an important determinant of immunity and disease outcome in intracellular bacterial infection...
  17. doi Infiltrating monocytes trigger EAE progression, but do not contribute to the resident microglia pool
    Bahareh Ajami
    University of British Columbia, Biomedical Research Centre, Vancouver, British Columbia, Canada
    Nat Neurosci 14:1142-9. 2011
    ..Inhibition of chemokine receptor-dependent recruitment of monocytes to the CNS blocked EAE progression, suggesting that these infiltrating cells are essential for pathogenesis...
  18. pmc Inflammatory monocytes recruited after skeletal muscle injury switch into antiinflammatory macrophages to support myogenesis
    Ludovic Arnold
    Institut National de la Sante et de la Recherche Medicale, Unite 841, Institut Mondor de Recherche Biomedicale, Cell Interactions in the Neuromuscular System Team, Universite Paris 12 Val de Marne, Creteil, France
    J Exp Med 204:1057-69. 2007
    ..In conclusion, injured skeletal muscle recruits MOs exhibiting inflammatory profiles that operate phagocytosis and rapidly convert to antiinflammatory MPs that stimulate myogenesis and fiber growth...
  19. doi Gene expression profiling reveals the defining features of the classical, intermediate, and nonclassical human monocyte subsets
    Kok Loon Wong
    Singapore Immunology Network, Agency for Science, Technology and Research, Singapore
    Blood 118:e16-31. 2011
    New official nomenclature subdivides human monocytes into 3 subsets: the classical (CD14(++)CD16(-)), intermediate (CD14(++)CD16(+)), and nonclassical (CD14(+)CD16(++)) monocytes...
  20. ncbi Microglia in the adult brain arise from Ly-6ChiCCR2+ monocytes only under defined host conditions
    Alexander Mildner
    Institute of Neuropathology, Georg August University, Gottingen, Germany
    Nat Neurosci 10:1544-53. 2007
    ..a panel of bone marrow chimeric and adoptive transfer experiments, we found that circulating Ly-6C(hi)CCR2(+) monocytes were preferentially recruited to the lesioned brain and differentiated into microglia...
  21. ncbi LPS induction of gene expression in human monocytes
    M Guha
    Departments of Immunology, C-204, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Cell Signal 13:85-94. 2001
    ..Recent studies have elucidated how LPS is recognized by monocytes and macrophages of the innate immune system...
  22. pmc The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions
    Matthias Nahrendorf
    Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    J Exp Med 204:3037-47. 2007
    Healing of myocardial infarction (MI) requires monocytes/macrophages...
  23. pmc Ly-6Chi monocytes dominate hypercholesterolemia-associated monocytosis and give rise to macrophages in atheromata
    Filip K Swirski
    Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Clin Invest 117:195-205. 2007
    ..Circulating monocytes, the precursors of macrophages, display heterogeneity in mice and humans, but their relative contribution to ..
  24. pmc Human CD14dim monocytes patrol and sense nucleic acids and viruses via TLR7 and TLR8 receptors
    Jerome Cros
    U838 INSERM, Universite Paris Descartes, Paris, France
    Immunity 33:375-86. 2010
    b>Monocytes are effectors of the inflammatory response to microbes...
  25. ncbi Use of Ly6G-specific monoclonal antibody to deplete neutrophils in mice
    Jean M Daley
    Department of Surgery, Division of Surgical Research, Rhode Island Hospital, NAB 214, 593 Eddy Street, Providence, RI 02903, USA
    J Leukoc Biol 83:64-70. 2008
    ..and to Ly6C, which is expressed on neutrophils, dendritic cells, and subpopulations of lymphocytes and monocytes. It is thus likely that in vivo administration of RB6-8C5 may deplete not only neutrophils but also other Gr-l+ (..
  26. ncbi The CD14+ CD16+ blood monocytes: their role in infection and inflammation
    Loems Ziegler-Heitbrock
    Department of Infection, Immunity and Inflammation, University of Leicester, Medical Sciences Building, University Road, Leicester, UK
    J Leukoc Biol 81:584-92. 2007
    Blood monocyte subpopulations have been defined in man initially, and the two major types of monocytes are the CD14++ CD16- and the CD14+ CD16+ monocytes...
  27. pmc Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo
    Marie Luise von Brühl
    Deutsches Herzzentrum and I Medizinische Klinik, Technische Universität München TUM, 80333 Munich, Germany
    J Exp Med 209:819-35. 2012
    ..We demonstrate by intravital two-photon and epifluorescence microscopy that blood monocytes and neutrophils crawling along and adhering to the venous endothelium provide the initiating stimulus for DVT ..
  28. pmc Ghrelin inhibits leptin- and activation-induced proinflammatory cytokine expression by human monocytes and T cells
    Vishwa Deep Dixit
    Laboratory of Immunology, National Institute on Aging, NIH, Baltimore, Maryland 21224, USA
    J Clin Invest 114:57-66. 2004
    ..Here we report that GHS-R and ghrelin are expressed in human T lymphocytes and monocytes, where ghrelin acts via GHS-R to specifically inhibit the expression of proinflammatory anorectic cytokines such ..
  29. doi Endotoxin tolerance: new mechanisms, molecules and clinical significance
    Subhra K Biswas
    Singapore Immunology Network, Biomedical Sciences Institutes, Agency for Science, Technology and Research, 04 01 Immunos, 8A Biomedical Drive, 138648 Singapore
    Trends Immunol 30:475-87. 2009
    Prior exposure of innate immune cells like monocytes/macrophages to minute amounts of endotoxin cause them to become refractory to subsequent endotoxin challenge, a phenomenon called "endotoxin tolerance"...
  30. ncbi Monocyte emigration from bone marrow during bacterial infection requires signals mediated by chemokine receptor CCR2
    Natalya V Serbina
    Infectious Disease Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, Immunology Program, Sloan Kettering Institute, New York, New York 10021, USA
    Nat Immunol 7:311-7. 2006
    b>Monocytes recruited to tissues mediate defense against microbes or contribute to inflammatory diseases. Regulation of the number of circulating monocytes thus has implications for disease pathogenesis...
  31. doi SuperSAGE evidence for CD14++CD16+ monocytes as a third monocyte subset
    Adam M Zawada
    Department of Internal Medicine IV, Saarland University Hospital, Homburg Saar, Germany
    Blood 118:e50-61. 2011
    b>Monocytes are a heterogeneous cell population with subset-specific functions and phenotypes...
  32. doi PVP-coated silver nanoparticles and silver ions induce reactive oxygen species, apoptosis and necrosis in THP-1 monocytes
    Rasmus Foldbjerg
    Department of Environmental and Occupational Medicine, Institute of Public Health, Aarhus University, Bartholins Alle 2, Bygn 1260, 8000 Aarhus, Denmark
    Toxicol Lett 190:156-62. 2009
    ..A drastic increase in ROS levels could be detected after 6-24h suggesting that oxidative stress is an important mediator of cytotoxicity caused by Ag NPs and Ag+...
  33. pmc Cellular microRNA expression correlates with susceptibility of monocytes/macrophages to HIV-1 infection
    Xu Wang
    Division of Allergy and Immunology, Joseph Stokes Jr Research Institute at The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Blood 113:671-4. 2009
    Although both monocytes and macrophages possess essential requirements for HIV-1 entry, peripheral blood monocytes are infrequently infected with HIV-1 in vivo and in vitro...
  34. pmc Induction and regulatory function of miR-9 in human monocytes and neutrophils exposed to proinflammatory signals
    Flavia Bazzoni
    Department of Pathology, Division of General Pathology, University of Verona, Strada Le Grazie 8, I 37134 Verona, Italy
    Proc Natl Acad Sci U S A 106:5282-7. 2009
    ..study, we characterize the profile of miRNAs induced by LPS in human polymorphonuclear neutrophils (PMN) and monocytes. In particular, we identify miR-9 as the only miRNA (among 365 analyzed) up-regulated in both cell types after ..
  35. pmc Integrating genome-wide genetic variations and monocyte expression data reveals trans-regulated gene modules in humans
    Maxime Rotival
    INSERM UMRS 937, Pierre and Marie Curie University UPMC, Paris 6 and Medical School, Paris, France
    PLoS Genet 7:e1002367. 2011
    ..multiple expression traits was replicated in Cardiogenics, an independent study in which expression profiles of monocytes were available in 758 subjects...
  36. doi Vaccine adjuvants alum and MF59 induce rapid recruitment of neutrophils and monocytes that participate in antigen transport to draining lymph nodes
    Samuele Calabro
    Novartis Vaccines and Diagnostics, Siena, Italy
    Vaccine 29:1812-23. 2011
    ..The earliest and most abundantly recruited cell type are neutrophils, followed by monocytes, eosinophils and later dendritic cells (DCs) and macrophages...
  37. doi The multifaceted contributions of leukocyte subsets to atherosclerosis: lessons from mouse models
    Christian Weber
    Institute for Molecular Cardiovascular Research, RWTH Aachen University, 52074 Aachen, Germany
    Nat Rev Immunol 8:802-15. 2008
    ..Improved understanding of the selective contributions of specific cell types to atherogenesis will pave the way for new targeted approaches to therapy...
  38. ncbi Blood monocytes consist of two principal subsets with distinct migratory properties
    Frederic Geissmann
    Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Immunity 19:71-82. 2003
    Peripheral blood monocytes are a heterogeneous population of circulating leukocytes...
  39. doi Type I interferon inhibits interleukin-1 production and inflammasome activation
    Greta Guarda
    Department of Biochemistry, University of Lausanne, Epalinges, Switzerland
    Immunity 34:213-23. 2011
    ..Importantly, monocytes from multiple sclerosis patients undergoing IFN-β treatment produced substantially less IL-1β than monocytes ..
  40. ncbi beta-Amyloid stimulation of microglia and monocytes results in TNFalpha-dependent expression of inducible nitric oxide synthase and neuronal apoptosis
    C K Combs
    Alzheimer Research Laboratory, Department of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    J Neurosci 21:1179-88. 2001
    ..Importantly, TNFalpha generated by the monocytes and microglia was responsible for the majority of the neuorotoxic activity secreted by these cells after beta-..
  41. pmc Experimental human cytomegalovirus latency in CD14+ monocytes
    Danna Hargett
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544 1014, USA
    Proc Natl Acad Sci U S A 107:20039-44. 2010
    CD14(+) monocytes are a reservoir for latent human cytomegalovirus, and virus replication is reactivated during their differentiation to macrophages or dendritic cells...
  42. doi Vitamin D3 induces autophagy in human monocytes/macrophages via cathelicidin
    Jae Min Yuk
    Department of Microbiology, College of Medicine, Chungnam National University, Daejeon, Korea
    Cell Host Microbe 6:231-43. 2009
    ..We show that 1,25-dihydroxyvitamin D3 (1,25D3), the active form of vitamin D, induced autophagy in human monocytes via cathelicidin, which activated transcription of the autophagy-related genes Beclin-1 and Atg5...
  43. ncbi How is mRNA expression predictive for protein expression? A correlation study on human circulating monocytes
    Yanfang Guo
    Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Changsha 410081, China
    Acta Biochim Biophys Sin (Shanghai) 40:426-36. 2008
    ..We carried out correlation analyses on mRNA-protein expressions in freshly isolated human circulating monocytes from 30 unrelated women...
  44. ncbi Absence of monocyte chemoattractant protein-1 reduces atherosclerosis in low density lipoprotein receptor-deficient mice
    L Gu
    Department of Adult Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Mol Cell 2:275-81. 1998
    Recruitment of blood monocytes into the arterial subendothelium is one of the earliest steps in atherogenesis. Monocyte chemoattractant protein-1 (MCP-1), a CC chemokine, is one likely signal involved in this process...
  45. pmc C-type lectins DC-SIGN and L-SIGN mediate cellular entry by Ebola virus in cis and in trans
    Carmen P Alvarez
    Laboratory of Molecular Microbiology, Dept of Microbiology, Hospital 12 de Octubre, 28041 Madrid, Spain
    J Virol 76:6841-4. 2002
    ..Our data underscore a role for DC-SIGN and L-SIGN in the infective process and pathogenicity of Ebola virus infection...
  46. pmc ATP is released by monocytes stimulated with pathogen-sensing receptor ligands and induces IL-1beta and IL-18 secretion in an autocrine way
    Alessandra Piccini
    Cell Biology Unit, National Cancer Research Institute, Largo Rosanna Benzi 10, 16132 Genoa, Italy
    Proc Natl Acad Sci U S A 105:8067-72. 2008
    ..Here, we show that in primary human monocytes microbial components acting on different pathogen-sensing receptors and the danger-associated molecule uric acid ..
  47. pmc Adult Langerhans cells derive predominantly from embryonic fetal liver monocytes with a minor contribution of yolk sac-derived macrophages
    Guillaume Hoeffel
    Singapore Immunology Network, Agency for Science, Technology and Research A STAR, Immunos Building 3 4, Biopolis, 138648, Singapore
    J Exp Med 209:1167-81. 2012
    ..which remain of YS origin throughout life, YS-derived LC precursors are largely replaced by fetal liver monocytes during late embryogenesis...
  48. pmc Modulating inflammatory monocytes with a unique microRNA gene signature ameliorates murine ALS
    Oleg Butovsky
    Department of Neurology, Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 122:3063-87. 2012
    ..Here we investigated the role of innate immunity in a mouse model of ALS. We found that inflammatory monocytes were activated and that their progressive recruitment to the spinal cord, but not brain, correlated with ..
  49. ncbi Circulating monocyte-platelet aggregates are a more sensitive marker of in vivo platelet activation than platelet surface P-selectin: studies in baboons, human coronary intervention, and human acute myocardial infarction
    A D Michelson
    Center for Platelet Function Studies, Departments of Pediatrics and Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Circulation 104:1533-7. 2001
    ..Platelet surface P-selectin is considered the "gold standard" marker of platelet activation. Degranulated, P-selectin-positive platelets, however, aggregate with leukocytes in vitro and rapidly lose surface P-selectin in vivo...
  50. pmc Inhibition of anti-HIV microRNA expression: a mechanism for opioid-mediated enhancement of HIV infection of monocytes
    Xu Wang
    Department of Pathology and Laboratory Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    Am J Pathol 178:41-7. 2011
    ..heroin), widely abused drugs among people infected with HIV, on the expression of cellular anti-HIV miRNAs in monocytes. We found that morphine-treated monocytes expressed lower levels of cellular anti-HIV miRNAs than untreated ..
  51. pmc Inflammation switches the differentiation program of Ly6Chi monocytes from antiinflammatory macrophages to inflammatory dendritic cells in the colon
    Aymeric Rivollier
    Mucosal Immunobiology Section, Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 209:139-55. 2012
    ..In noninflammatory conditions, Ly6C(hi) monocytes (MOs) differentiated primarily into CD11c(+) but not CD11c(-) MPs...
  52. doi Activated monocytes in peritumoral stroma of hepatocellular carcinoma promote expansion of memory T helper 17 cells
    Dong Ming Kuang
    State Key Laboratory of Oncology in Southern China, Cancer Center, Guangzhou, P R China
    Hepatology 51:154-64. 2010
    ..Most peritumoral CD68(+) cells exhibited an activated phenotype. Accordingly, tumor-activated monocytes were significantly superior to the suppressive tumor macrophages in inducing expansion of Th17 cells from ..
  53. ncbi Hepatitis C core and nonstructural 3 proteins trigger toll-like receptor 2-mediated pathways and inflammatory activation
    Angela Dolganiuc
    Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Gastroenterology 127:1513-24. 2004
    ..reported that hepatitis C virus (HCV) core and nonstructural 3 (NS3) proteins activate inflammatory pathways in monocytes. The aim of this study was to investigate the role of TLRs in innate immune cell activation by core and NS3 ..
  54. ncbi Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-kappaB
    Y Ogura
    Department of Pathology and Comprehensive Cancer Center, The University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Biol Chem 276:4812-8. 2001
    ..Although Nod1 and Apaf-1 were broadly expressed in tissues, the expression of Nod2 was highly restricted to monocytes. Nod2 induced nuclear factor kappaB (NF-kappaB) activation, which required IKKgamma and was inhibited by ..
  55. pmc miR-198 inhibits HIV-1 gene expression and replication in monocytes and its mechanism of action appears to involve repression of cyclin T1
    Tzu Ling Sung
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS Pathog 5:e1000263. 2009
    ..Translation of Cyclin T1 mRNA has been shown to be repressed in human monocytes, and this repression is relieved when cells differentiate to macrophages...
  56. doi Altered M1/M2 activation patterns of monocytes in severe relapsing experimental rat model of multiple sclerosis. Amelioration of clinical status by M2 activated monocyte administration
    Joanna Mikita
    University Victor Segalen, France
    Mult Scler 17:2-15. 2011
    We investigated proinflammatory M1 and immunomodulatory M2 activation profiles of circulating monocytes in relapsing experimental autoimmune encephalomyelitis (EAE) model of multiple sclerosis, and tested whether altered M1/M2 ..
  57. ncbi Regulation of scavenger receptor CD163 expression in human monocytes and macrophages by pro- and antiinflammatory stimuli
    C Buechler
    Institut fur Klinische Chemie und Laboratoriumsmedizin, Klinikum der Universitat Regensburg, Germany
    J Leukoc Biol 67:97-103. 2000
    ..In freshly isolated monocytes the CD14bright CD16+ monocyte subset revealed the highest expression of CD163 among all monocyte subsets...
  58. pmc Monocytes in atherosclerosis: subsets and functions
    Kevin J Woollard
    Center for Molecular and Cellular Biology of Inflammation CMCBI, Division of Immunology, Infection and Inflammatory Diseases DIIID, Guys Campus, London SE1 1UL, UK
    Nat Rev Cardiol 7:77-86. 2010
    ..Plaque macrophages account for the majority of leukocytes in plaques, and are believed to differentiate from monocytes recruited from circulating blood. However, monocytes represent a heterogenous circulating population of cells...
  59. doi The phagocytes: neutrophils and monocytes
    David C Dale
    Department of Medicine, University of Washington School of Medicine, Seattle A98195, USA
    Blood 112:935-45. 2008
    ..demonstrated the high production rate and short lifespan of neutrophils and allowed researchers to follow the monocytes as they moved from the marrow through the blood to become tissue macrophages, histiocytes, and dendritic cells...
  60. doi A distinguishing gene signature shared by tumor-infiltrating Tie2-expressing monocytes, blood "resident" monocytes, and embryonic macrophages suggests common functions and developmental relationships
    Ferdinando Pucci
    Angiogenesis and Tumor Targeting Research Unit, San Raffaele Institute, Olgettina 58, Milan, Italy
    Blood 114:901-14. 2009
    We previously showed that Tie2-expressing monocytes (TEMs) have nonredundant proangiogenic activity in tumors...
  61. pmc Differential requirement for the activation of the inflammasome for processing and release of IL-1beta in monocytes and macrophages
    Mihai G Netea
    Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, USA
    Blood 113:2324-35. 2009
    ..Here we demonstrate that human blood monocytes release processed IL-1beta after a one-time stimulation with either TLR2 or TLR4 ligands, resulting from ..
  62. pmc miR-146a is critical for endotoxin-induced tolerance: IMPLICATION IN INNATE IMMUNITY
    Md A Nahid
    Department of Oral Biology, University of Florida, Gainesville, Florida 32610, USA
    J Biol Chem 284:34590-9. 2009
    ..Thus our studies demonstrated that miR-146a is critical for the in vitro monocytic cell-based endotoxin tolerance...
  63. ncbi Magnetic resonance tracking of dendritic cells in melanoma patients for monitoring of cellular therapy
    I Jolanda M de Vries
    Department of Tumor Immunology, Radboud University Nijmegen Medical Center and Nijmegen Center for Molecular Life Sciences, Geert Grooteplein 28, 6500 HB Nijmegen, The Netherlands
    Nat Biotechnol 23:1407-13. 2005
    ..MRI cell tracking using iron oxides appears clinically safe and well suited to monitor cellular therapy in humans...
  64. ncbi The chemokine system in diverse forms of macrophage activation and polarization
    Alberto Mantovani
    Centro di Eccellenza per l Innovazione Diagnostica e Terapeutica IDET, Institute of General Pathology, University of Milan, I 20133 Milan, Italy Istituto di Ricerche Farmacologiche Mario Negri, I 20157 Milan, Italy
    Trends Immunol 25:677-86. 2004
    ....
  65. pmc SIVSM/HIV-2 Vpx proteins promote retroviral escape from a proteasome-dependent restriction pathway present in human dendritic cells
    Caroline Goujon
    LaboRetro, INSERM U758, Ecole Normale Superieure de Lyon, IFR 128 Biosciences Lyon Gerland, Lyon Biopole, France
    Retrovirology 4:2. 2007
    ..However, since the requirement for Vpx is specific for DCs and not for other non-dividing cell types, this suggests that Vpx may play a role other than nuclear import...
  66. pmc Altered redox state of monocytes from cryopyrin-associated periodic syndromes causes accelerated IL-1beta secretion
    Sara Tassi
    Cell Biology Unit, National Cancer Research Institute, 16132 Genoa, Italy
    Proc Natl Acad Sci U S A 107:9789-94. 2010
    In healthy monocytes, Toll-like receptor (TLR) engagement induces production of reactive oxygen species (ROS), followed by an antioxidant response involved in IL-1beta processing and secretion...
  67. pmc Apoptosis-associated speck-like protein (ASC) controls Legionella pneumophila infection in human monocytes
    Dalia H Abdelaziz
    Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Center for Microbial Interface Biology and the Department of Internal Medicine, Ohio State University, Columbus, Ohio 43210, USA
    J Biol Chem 286:3203-8. 2011
    ..pneumophila to cause pneumonia is determined by its capability to evade the immune system and grow within human monocytes and their derived macrophages...
  68. pmc The identification of markers of macrophage differentiation in PMA-stimulated THP-1 cells and monocyte-derived macrophages
    Marc Daigneault
    Department of Infection and Immunity, Medical School, University of Sheffield, Sheffield, United Kingdom
    PLoS ONE 5:e8668. 2010
    ..cell line after various protocols of differentiation utilising VD(3) and PMA in comparison to primary human monocytes or monocyte-derived macrophages (MDM)...
  69. pmc A cellular restriction dictates the permissivity of nondividing monocytes/macrophages to lentivirus and gammaretrovirus infection
    Rajnish Kaushik
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Cell Host Microbe 6:68-80. 2009
    ..We further demonstrate that this restriction prevents transduction of quiescent monocytes by HIV-1...
  70. doi Soluble cell adhesion molecules in monocytes of Alzheimer's disease and mild cognitive impairment
    Tanja Hochstrasser
    Department of General and Social Psychiatry, Innsbruck Medical University, Austria
    Exp Gerontol 45:70-4. 2010
    ..The microglial compartment may arise to a greater part from activation and transmigration of circulating monocytes. The aim of the present pilot study was to explore, if different cell adhesion molecules (ICAM-1 and -3, PECAM-1,..
  71. pmc Interaction of Vpx and apolipoprotein B mRNA-editing catalytic polypeptide 3 family member A (APOBEC3A) correlates with efficient lentivirus infection of monocytes
    Andre Berger
    Division of Medical Biotechnology, Paul Ehrlich Institut, 63225 Langen, Germany
    J Biol Chem 285:12248-54. 2010
    ..HIV-1, which does not encode Vpx, is not able to infect human monocytes, but Vpx enables infection with HIV-1. The underlying mechanism is not completely understood...
  72. pmc Heat shock protein 90 and heat shock protein 70 are components of dengue virus receptor complex in human cells
    Jorge Reyes-Del Valle
    Departamento de Patologia Experimental, Centro de Investigacion y de Estudios Avanzados del IPN, Av I P N 2508, Col San Pedro Zacatenco, Mexico City D F, C P 07360, Mexico
    J Virol 79:4557-67. 2005
    ..Based on the ability of HSP90 (84 kDa) to interact with HSP70 (74 kDa) on the surface of monocytes during lipopolysaccharide (LPS) signaling and evidence that LPS inhibits dengue virus infection, the presence of ..
  73. pmc Circulating monocytes from systemic sclerosis patients with interstitial lung disease show an enhanced profibrotic phenotype
    Susan K Mathai
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA
    Lab Invest 90:812-23. 2010
    Profibrotic cells derived from circulating CD14+ monocytes include fibrocytes and alternatively activated macrophages...
  74. doi Migrating monocytes recruited to the spleen play an important role in control of blood stage malaria
    Anne Marit Sponaas
    Division of Parasitology, Medical Research Council MRC National Institute for Medical Research, London, UK
    Blood 114:5522-31. 2009
    ..During Plasmodium chabaudi infection in mice, a population of CD11b(high)Ly6C(+) monocytes are generated in bone marrow, most of which depend on the chemokine receptor CCR2 for migration from bone marrow ..
  75. ncbi CD38 orchestrates migration, survival, and Th1 immune response of human mature dendritic cells
    Loredana Frasca
    Department of Infectious, Parasitic, and Immune Mediated Diseases, Istituto Superiore di Sanita, Rome, Italy
    Blood 107:2392-9. 2006
    ..These findings may lay out the basis to assess the functional role(s) of human CD38 in infections, autoimmune diseases, and neoplastic disorders...
  76. ncbi Oxidized low-density and high-density lipoproteins regulate the production of matrix metalloproteinase-1 and -9 by activated monocytes
    Jeanette A Ardans
    Immunopathology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Leukoc Biol 71:1012-8. 2002
    b>Monocytes/macrophages are prominent in atherosclerotic plaques where the vascular remodeling and plaque rupture may be influenced by the lipids and cytokines at these sites...
  77. doi Cerebral microglia recruit monocytes into the brain in response to tumor necrosis factoralpha signaling during peripheral organ inflammation
    Charlotte D'Mello
    Immunology Research Group, Department of Medicine, University of Calgary, Calgary, Alberta, Canada T2N 4N1
    J Neurosci 29:2089-102. 2009
    ..using a mouse model of inflammatory liver injury, we have confirmed the significant infiltration of activated monocytes into the brain in mice with hepatic inflammation and have defined the mechanism that mediates this trafficking ..
  78. doi Programmed death-1-induced interleukin-10 production by monocytes impairs CD4+ T cell activation during HIV infection
    Elias A Said
    Centre de recherche du Centre hospitalier de l Université de Montréal CRCHUM, Hôpital St Luc, Montreal, Quebec, Canada
    Nat Med 16:452-9. 2010
    ..and inflammatory cytokines in the plasma of HIV-infected subjects lead to upregulation of PD-1 expression on monocytes that correlates with high plasma concentrations of IL-10...
  79. doi Enolase-1 promotes plasminogen-mediated recruitment of monocytes to the acutely inflamed lung
    Malgorzata Wygrecka
    Department of Biochemistry, Faculty of Medicine, University of Giessen Lung Center, Giessen, Germany
    Blood 113:5588-98. 2009
    ..LPS)-driven chemokine-directed monocyte migration and matrix invasion in vitro, as well as recruitment of monocytes to the alveolar compartment in vivo...
  80. pmc Comparison of gene expression profiles between human and mouse monocyte subsets
    Molly A Ingersoll
    Department of Gene and Cell Medicine and Immunology Institute, Mount Sinai School of Medicine, New York, NY, USA
    Blood 115:e10-9. 2010
    ..differences included a prominent peroxisome proliferator-activated receptor gamma (PPARgamma) signature in mouse monocytes, which is absent in humans, and strikingly opposed patterns of receptors involved in uptake of apoptotic cells ..
  81. pmc Ly6c+ "inflammatory monocytes" are microglial precursors recruited in a pathogenic manner in West Nile virus encephalitis
    Daniel R Getts
    The Discipline of Pathology, School of Medical Sciences, The University of Sydney, Sydney NSW 2006, Australia
    J Exp Med 205:2319-37. 2008
    ..Depletion of "circulating" (Gr1(-)(Ly6C(lo))CX3CR1(+)) and "inflammatory" (Gr1(hi)/Ly6C(hi)/CCR2(+)) classical monocytes during infection abrogated the increase in microglia...
  82. ncbi High mobility group box 1 protein binding to lipopolysaccharide facilitates transfer of lipopolysaccharide to CD14 and enhances lipopolysaccharide-mediated TNF-alpha production in human monocytes
    Ju Ho Youn
    Department of Microbiology, Brain Korea 21 Project for Medical Science, National Core Research Center for Nanomedical Technology, Yonsei University College of Medicine, Seoul, Republic of Korea
    J Immunol 180:5067-74. 2008
    ..HMGB1 and LPS treatment results in a higher increase in TNF-alpha production in human PBMCs and peripheral blood monocytes than LPS or HMGB1 treatment alone or their summation...
  83. pmc Influence of bevacizumab, sunitinib and sorafenib as single agents or in combination on the inhibitory effects of VEGF on human dendritic cell differentiation from monocytes
    C Alfaro
    Gene Therapy and Hepatology Division, CIMA, Universidad de Navarra, Pamplona, Spain
    Br J Cancer 100:1111-9. 2009
    ..of renal carcinoma cell lines cultured under hypoxia were found to alter the differentiation of human monocytes to DC. Resulting DC showed impaired activity, as assessed by the alloreactive mixed T-lymphocyte reaction...
  84. doi Metalloproteinase expression in monocytes and macrophages and its relationship to atherosclerotic plaque instability
    Andrew C Newby
    Bristol Heart Institute, Bristol Royal Infirmary, Bristol BS2 8HW, UK
    Arterioscler Thromb Vasc Biol 28:2108-14. 2008
    ..Moreover, recent evidence suggests that different macrophage phenotypes express characteristically different spectra of MMPs and their inhibitors. New therapies may result from targeting matrix MMP overproduction...
  85. pmc Coronary intraplaque hemorrhage evokes a novel atheroprotective macrophage phenotype
    Joseph J Boyle
    Vascular Sciences Section, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0NN, U K
    Am J Pathol 174:1097-108. 2009
    ..Differentiating monocytes with HbHp complexes reproduced the CD163(high) human leukocyte antigen-DR(low) HA-mac phenotype in vitro...
  86. doi A new pathway of staphylococcal pathogenesis: apoptosis-like death induced by Staphopain B in human neutrophils and monocytes
    Jan Smagur
    Department of Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland
    J Innate Immun 1:98-108. 2009
    Circulating neutrophils and monocytes form the first line of cellular defense against invading bacteria. Here, we describe a novel and specific mechanism of disabling and eliminating phagocytes by Staphylococcus aureus...
  87. pmc Monocytes from patients with type 1 diabetes spontaneously secrete proinflammatory cytokines inducing Th17 cells
    Elizabeth M Bradshaw
    Division of Molecular Immunology, Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 183:4432-9. 2009
    ..We examined the monocytes isolated directly from the blood of T1D patients and found they spontaneously secreted the proinflammatory ..
  88. pmc Mycobacteria exploit p38 signaling to affect CD1 expression and lipid antigen presentation by human dendritic cells
    Maria Cristina Gagliardi
    Dipartimento di Malattie Infettive, Parassitarie e Immunomediate, Istituto Superiore di Sanita, Viale Regina Elena, 299, 00161 Roma, Italy
    Infect Immun 77:4947-52. 2009
    ..that Mycobacterium tuberculosis and bacillus Calmette-Guérin (Mycobacterium bovis BCG) induce human monocytes to differentiate into CD1- dendritic cells (DC), which cannot present lipid antigens to specific T cells...
  89. pmc Homogeneous monocytes and macrophages from human embryonic stem cells following coculture-free differentiation in M-CSF and IL-3
    Karl R Karlsson
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, UK
    Exp Hematol 36:1167-75. 2008
    To develop a simple and efficient method for producing homogeneous populations of monocytes and macrophages from human embryonic stem cells (hES).
  90. pmc HIV-1 transforms the monocyte plasma membrane proteome
    Irena Kadiu
    Department of Pharmacology and Experimental Neuroscience, Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, NE 68198 5880, USA
    Cell Immunol 258:44-58. 2009
    ..In contrast, PMA-treated monocytes bypassed caspase 3, 9 pathways and lead to cathepsin B-dependent necrosis...
  91. doi Quantitative expression of RIG-like helicase, NOD-like receptor and inflammasome-related mRNAs in humans and mice
    Maciej Lech
    Medizinische Poliklinik, University of Munich, 80336 Munich, Germany
    Int Immunol 22:717-28. 2010
    ..Resting human and mouse monocytes and T cells expressed most molecules and produced IL-1 beta and CCL5/RANTES upon activation...
  92. pmc Sialoadhesin expressed on IFN-induced monocytes binds HIV-1 and enhances infectivity
    Hans Rempel
    Department of Laboratory Medicine at the Veterans Affairs Medical Center, San Francisco, California, United States of America
    PLoS ONE 3:e1967. 2008
    HIV-1 infection dysregulates the immune system and alters gene expression in circulating monocytes. Differential gene expression analysis of CD14(+) monocytes from subjects infected with HIV-1 revealed increased expression of ..
  93. pmc Adiponectin primes human monocytes into alternative anti-inflammatory M2 macrophages
    Fina Lovren
    Division of Cardiac Surgery, Keenan Research Centre in Li Ka Shing Knowledge Institute of St Michael s Hospital, Toronto, Ontario, Canada
    Am J Physiol Heart Circ Physiol 299:H656-63. 2010
    ..Because monocytes can differentiate into either proatherogenic M1 macrophages or anti-inflammatory M2 macrophages, approaches that ..
  94. pmc Cyclic di-GMP signaling regulates invasion by Ehrlichia chaffeensis of human monocytes
    Yumi Kumagai
    Department of Veterinary Biosciences, The Ohio State University, Columbus, OH 43210, USA
    J Bacteriol 192:4122-33. 2010
    ..Furthermore, anti-HtrA inhibited CDGA-induced TRP120 degradation. Our results suggest that E. chaffeensis invasion is regulated by c-di-GMP signaling, which stabilizes some bacterial surface-exposed proteins against proteases...
  95. ncbi Monocytes contribute to the atherosclerotic cap by transformation into fibrocytes
    H J Medbury
    Vascular Biology Research Centre, Department of Surgery, University of Sydney, Westmead Hospital, Westmead, NSW, Australia
    Int Angiol 27:114-23. 2008
    ..Recent evidence suggests that circulating progenitors may be a source of these cells. We hypothesized that they may be fibrocytes bone-marrow derived cells that acquire SM-like characteristics, including the expression of SM alfa actin...
  96. pmc Type I interferon modulates monocyte recruitment and maturation in chronic inflammation
    Pui Y Lee
    Center for Autoimmune Disease, University of Florida, Gainesville, 32610 0221, USA
    Am J Pathol 175:2023-33. 2009
    Chronic inflammation is characterized by continuous recruitment and activation of immune cells such as monocytes in response to a persistent stimulus...
  97. pmc Activated monocytes in peritumoral stroma of hepatocellular carcinoma foster immune privilege and disease progression through PD-L1
    Dong Ming Kuang
    State Key Laboratory of Biocontrol, Sun Yat Sen University, Guangzhou 510 275, China
    J Exp Med 206:1327-37. 2009
    ..recently found that tumors can alter the normal developmental process of Mphi to trigger transient activation of monocytes in peritumoral stroma...
  98. doi The myeloid-related proteins 8 and 14 complex, a novel ligand of toll-like receptor 4, and interleukin-1beta form a positive feedback mechanism in systemic-onset juvenile idiopathic arthritis
    Michael Frosch
    University of Muenster, Muenster, Germany
    Arthritis Rheum 60:883-91. 2009
    ..We undertook this study to analyze the relevance of myeloid-related proteins (MRPs) 8 and 14, endogenous activators of Toll-like receptor 4, in diagnosis and pathogenesis of systemic-onset JIA...
  99. doi Inhibition of bone and muscle metastases of lung cancer cells by a decrease in the number of monocytes/macrophages
    Koji Hiraoka
    Department of Orthopedic Surgery, Kurume University Schoool of Medicine, Kurume 830 0011, Japan
    Cancer Sci 99:1595-602. 2008
    ..In this study, we examined the effect of a decrease in the number of monocytes/macrophages in peripheral blood and the tumor stroma on the development of bone and muscle metastases by lung ..
  100. pmc Phenotyping of peripheral blood mononuclear cells during acute dengue illness demonstrates infection and increased activation of monocytes in severe cases compared to classic dengue fever
    Anna P Durbin
    Johns Hopkins Bloomberg School of Public Health, 624 North Broadway, Room 251, Baltimore, MD 21205, USA
    Virology 376:429-35. 2008
    ..DEN prM was detected primarily in activated monocytes (CD14(+), CD32(+), CD86(+), CD11c(+))...
  101. pmc Soluble CD276 (B7-H3) is released from monocytes, dendritic cells and activated T cells and is detectable in normal human serum
    Guangbo Zhang
    Clinical Immunology Laboratory, Suzhou University No 1 Affiliated Hospital, Suzhou, China
    Immunology 123:538-46. 2008
    Expression of membrane CD276 (mB7-H3) has been reported on dendritic cells (DCs), monocytes, activated T cells, and various carcinoma cells. However, reports concerning its in vivo function have been inconsistent...

Research Grants91

  1. THE CHEMOKINE RECEPTOR CXCR-2 IN ATHEROSCLEROSIS
    William Boisvert; Fiscal Year: 2002
    ..First they will determine if retention of lesion monocytes is greater in LDLR-/-, mIL-8RH+/+ than LDLR-/-, mIL-8RH-/- mice...
  2. REGULATION OF INDUCIBLE GENE EXPRESSION IN MONOCYTES
    Nigel Mackman; Fiscal Year: 2007
    ..Lipopolysaccharide (LPS [endotoxin]) from Gram-negative bacteria induces monocytes and endothelial cells to express the procoagulant protein tissue factor (TF), which initiates disseminated ..
  3. HO-1 and granuloma formation in TB pleurisy
    Veena B Antony; Fiscal Year: 2010
    ..b>Monocytes are recruited to the site of tuberculous infection by the interaction of C-C chemokines, (mainly monocyte ..
  4. ADENINE DEOXYNUCLEOTIDE METABOLISM AND IMMUNE FUNCTION
    Dennis Carson; Fiscal Year: 1993
    Lymphocytes and monocytes are critical cells in the pathogenesis of immunodeficiency, autoimmune, and certain malignant diseases...
  5. MONOCYTE ADHESION TO ATHEROMA IN GENE TARGETED MICE
    Klaus Ley; Fiscal Year: 2000
    ..An important component of atherosclerotic lesions is the presence of foam cells derived from blood monocytes which infiltrate the vessel wall at an early stage of lesion development...
  6. EMAP II, a molecular link of inflammation and apoptosis in pulmonary emphysema.
    Matthias Clauss; Fiscal Year: 2009
    ..effect of EMAP II on endothelial cells, coupled with its ability to activate and recruit pro-inflammatory monocytes, we hypothesize that excessive EMAP II release in response to cigarette smoking engages both lung endothelial ..
  7. EMAP II, a molecular link of inflammation and apoptosis in pulmonary emphysema.
    Irina Petrache; Fiscal Year: 2010
    ..effect of EMAP II on endothelial cells, coupled with its ability to activate and recruit pro-inflammatory monocytes, we hypothesize that excessive EMAP II release in response to cigarette smoking engages both lung endothelial ..
  8. HDL Modulation of monocyte function in endotoxemia
    C Roger White; Fiscal Year: 2010
    ..Under inflammatory conditions, monocytes infiltrate the artery wall and differentiate to either dendritic cells (DCs) or macrophages (MF)...
  9. HDL Modulation of monocyte function in endotoxemia
    Geeta Datta; Fiscal Year: 2009
    ..Under inflammatory conditions, monocytes infiltrate the artery wall and differentiate to either dendritic cells (DCs) or macrophages (MF)...
  10. HDL Modulation of monocyte function in endotoxemia
    Geeta Datta; Fiscal Year: 2009
    ..Under inflammatory conditions, monocytes infiltrate the artery wall and differentiate to either dendritic cells (DCs) or macrophages (MF)...
  11. REGULATION OF INDUCIBLE GENE EXPRESSION IN MONOCYTES
    Nigel Mackman; Fiscal Year: 2009
    ..Lipopolysaccharide (LPS [endotoxin]) from Gram-negative bacteria induces monocytes and endothelial cells to express the procoagulant protein tissue factor (TF), which initiates disseminated ..
  12. Differentiation/migratory fate of monocyte-derived cells
    Gwendalyn J Randolph; Fiscal Year: 2010
    ..Indeed, no information is available on whether the two major subsets of monocytes are cleared from sites of inflammation by different mechanisms...
  13. MONOCYTE RECRUITMENT IN PLEUROPULMONARY TB IN AIDS
    Veena Antony; Fiscal Year: 2005
    ..b>Monocytes are recruited to the site of tuberculous infection by the interaction of C-C chemokines, (mainly monocyte ..
  14. METALLOTHIONEIN, MERCURY AND MONOCYTE ACTIVATION
    RUDOLFS ZALUPS; Fiscal Year: 2006
    ..Activation is the acute phase response and respiratory burst undergone by monocytes (and other leukocytes) as a response to extracellular events and signals...
  15. Monocyte Modulation in LAgP
    SUZANNE BARBOUR; Fiscal Year: 2005
    ..Several lines of evidence suggest that LAgP monocytes exhibit a unique phenotype...
  16. Lung Endothelial Barrier Function and its Deregulation by Sickle Erythrocytes
    Solomon Ofori Acquah; Fiscal Year: 2007
    ..cells fulfill a central role in the response to inflammation by controlling the number of circulating monocytes recruited to interstitial tissue compartments...
  17. Monocyte Adhesion to Atheroma in Gene Targeted
    Klaus Ley; Fiscal Year: 2005
    Atherosclerosis is considered an inflammatory disease triggered by the entry of monocytes into the wall of large arteries, where they differentiate into macrophages and foam cells and promote growth and dedifferentiation of smooth ..
  18. ETHANOLS ROLE MEDIATION OF MONOCYTE IMMUNOSUPPRESSION
    Gyongyi Szabo; Fiscal Year: 2003
    ..These experiments will define monocyte alterations leading to the combined immunosuppressive effects of in vivo ethanol uptake and trauma. ..
  19. Monocyte activation and the role of CD11c in obesity-linked metabolic syndrome
    Huaizhu Wu; Fiscal Year: 2010
    ..CD11c is a b2 integrin primarily expressed on monocytes/macrophages and dendritic cells (DCs) that is a marker for monocyte/macrophage activation and participates in ..
  20. TRANSGENIC MICE, INFLAMMATION & THE ALZHEIMER PHENOTYPE
    Marcia N Gordon; Fiscal Year: 2010
    ..As an alternative delivery method, we propose to evaluate the use of monocytes, cells normally found in blood, as vectors to transport therapeutic genes to the brain...
  21. Monocyte Adhesive Hyaluronan Structures in Diabetes
    Aimin Wang; Fiscal Year: 2007
    ..and proliferation of the glomerular mesangial cells, followed by a prominent glomerular infiltration of monocytes and macrophages...
  22. Dopamine alters CNS migration of uninfected and HIV infected leukocytes to SDF-1
    JOAN BERMAN; Fiscal Year: 2009
    ..Some studies have found that drug abuse increases the number of T lymphocytes and monocytes that enter the brain during HIV infection when compared to infected individuals without a history of drug abuse ..
  23. Dopamine alters CNS migration of uninfected and HIV infected leukocytes to SDF-1
    JOAN WEINBERGER BERMAN; Fiscal Year: 2010
    ..Some studies have found that drug abuse increases the number of T lymphocytes and monocytes that enter the brain during HIV infection when compared to infected individuals without a history of drug abuse ..
  24. Monocyte Pathogenesis: Regulation of NADPH Oxidase
    MARTHA CATHCART; Fiscal Year: 2007
    The production of superoxide anion (02-) by activated monocytes and neutrophils is an essential element of host defense and inflammation. 02- is generated via the enzyme complex, NADPH oxidase...