cytotoxic t lymphocytes

Summary

Summary: Immunized T-lymphocytes which can directly destroy appropriate target cells. These cytotoxic lymphocytes may be generated in vitro in mixed lymphocyte cultures (MLC), in vivo during a graft-versus-host (GVH) reaction, or after immunization with an allograft, tumor cell or virally transformed or chemically modified target cell. The lytic phenomenon is sometimes referred to as cell-mediated lympholysis (CML). These CD8-positive cells are distinct from natural killer cells (KILLER CELLS, NATURAL) and from KILLER CELLS mediating antibody-dependent cell cytotoxicity. There are two effector phenotypes: TC1 and TC2.

Top Publications

  1. ncbi T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions
    S P Schoenberger
    Department of Immunohematology and Blood Bank, University Hospital Leiden, The Netherlands
    Nature 393:480-3. 1998
  2. ncbi Help for cytotoxic-T-cell responses is mediated by CD40 signalling
    S R Bennett
    Immunology Division, The Walter and Eliza Hall Institute of Medical Research, PO The Royal Melbourne Hospital, Victoria, Australia
    Nature 393:478-80. 1998
  3. ncbi Cytotoxic T lymphocytes established by seasonal human influenza cross-react against 2009 pandemic H1N1 influenza virus
    Wenwei Tu
    Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Room L7 58, 7 F Laboratory Block, Faculty of Medicine Building, 21 Sassoon Road, Hong Kong
    J Virol 84:6527-35. 2010
  4. ncbi Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion
    Haidong Dong
    Department of Immunology, Mayo Clinic, Rochester, Minnesota, USA
    Nat Med 8:793-800. 2002
  5. ncbi Regulatory T cells reversibly suppress cytotoxic T cell function independent of effector differentiation
    Thorsten R Mempel
    CBR Institute for Biomedical Research and Department of Pathology, Harvard Medical School, 200 Longwood Avenue, Boston, Massachusetts 02115, USA
    Immunity 25:129-41. 2006
  6. ncbi A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell
    J P Ridge
    Ghost Lab, Section on T cell Tolerance and Memory, Laboratory of Cellular and Molecular Immunology, NIAID NIH, Bethesda, Maryland 20892, USA
    Nature 393:474-8. 1998
  7. ncbi The Fas death factor
    S Nagata
    Osaka Bioscience Institute, Japan
    Science 267:1449-56. 1995
  8. ncbi A gene encoding an antigen recognized by cytolytic T lymphocytes on a human melanoma
    P van der Bruggen
    Ludwig Institute for Cancer Research, Brussels, Belgium
    Science 254:1643-7. 1991
  9. ncbi Natural selection of tumor variants in the generation of "tumor escape" phenotypes
    Hung T Khong
    National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Nat Immunol 3:999-1005. 2002
  10. ncbi Control of viremia in simian immunodeficiency virus infection by CD8+ lymphocytes
    J E Schmitz
    Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Science 283:857-60. 1999

Research Grants

  1. Identification of biomarkers of fatty acid intake
    Hannia Campos; Fiscal Year: 2002
  2. CHARACTERIZATION OF THE MURINE COMPLEMENT RECEPTORS
    JOHN WEIS; Fiscal Year: 1993
  3. Define the role of dendritic cells in HTLV-1 associated neuroinflammatory disease
    Pooja Jain; Fiscal Year: 2009
  4. Define the role of dendritic cells in HTLV-1 associated neuroinflammatory disease
    Pooja Jain; Fiscal Year: 2010
  5. Define the role of dendritic cells in HTLV-1 associated neuroinflammatory disease
    Pooja Jain; Fiscal Year: 2011
  6. TH1 CYTOKINES AND IMPAIRED CD8* CTLS IN ELDERLY
    Innocent Mbawuike; Fiscal Year: 2001
  7. PATHOGENESIS OF HEPATITIS B VIRUS IN TRANSGENIC MICE
    FRANCIS CHISARI; Fiscal Year: 2004
  8. Differentiation of Glioma from Radiation Injury Using Cellular MRI
    Syed Ali; Fiscal Year: 2007
  9. Engineered tumor-specific T cells Resist Hypoxic-Tumor Immunosuppressive Attacks.
    Patricia Yotnda; Fiscal Year: 2010
  10. HIV-1 Specific Cytotoxic T Lymphocytes in Breastmilk
    Grace John Stewart; Fiscal Year: 2003

Detail Information

Publications301 found, 100 shown here

  1. ncbi T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions
    S P Schoenberger
    Department of Immunohematology and Blood Bank, University Hospital Leiden, The Netherlands
    Nature 393:480-3. 1998
    Although in vivo priming of CD8+ cytotoxic T lymphocytes (CTLs) generally requires the participation of CD4+ T-helper lymphocytes, the nature of the 'help' provided to CTLs is unknown...
  2. ncbi Help for cytotoxic-T-cell responses is mediated by CD40 signalling
    S R Bennett
    Immunology Division, The Walter and Eliza Hall Institute of Medical Research, PO The Royal Melbourne Hospital, Victoria, Australia
    Nature 393:478-80. 1998
    b>Cytotoxic T lymphocytes (CTLs) which carry the CD8 antigen recognize antigens that are presented on target cells by the class I major histocompatibility complex...
  3. ncbi Cytotoxic T lymphocytes established by seasonal human influenza cross-react against 2009 pandemic H1N1 influenza virus
    Wenwei Tu
    Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Room L7 58, 7 F Laboratory Block, Faculty of Medicine Building, 21 Sassoon Road, Hong Kong
    J Virol 84:6527-35. 2010
    ..In this study, we demonstrate that the bulk memory cytotoxic T lymphocytes (CTLs) established by seasonal influenza viruses from healthy individuals who have not been exposed to ..
  4. ncbi Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion
    Haidong Dong
    Department of Immunology, Mayo Clinic, Rochester, Minnesota, USA
    Nat Med 8:793-800. 2002
    ..These findings have implications for the design of T cell-based cancer immunotherapy...
  5. ncbi Regulatory T cells reversibly suppress cytotoxic T cell function independent of effector differentiation
    Thorsten R Mempel
    CBR Institute for Biomedical Research and Department of Pathology, Harvard Medical School, 200 Longwood Avenue, Boston, Massachusetts 02115, USA
    Immunity 25:129-41. 2006
    ..using multiphoton intravital microscopy in lymph nodes (LNs) of anesthetized mice, we have analyzed how cytotoxic T lymphocytes (CTLs) interact with antigen-presenting target cells in the presence or absence of activated T(reg) cells...
  6. ncbi A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell
    J P Ridge
    Ghost Lab, Section on T cell Tolerance and Memory, Laboratory of Cellular and Molecular Immunology, NIAID NIH, Bethesda, Maryland 20892, USA
    Nature 393:474-8. 1998
    ....
  7. ncbi The Fas death factor
    S Nagata
    Osaka Bioscience Institute, Japan
    Science 267:1449-56. 1995
    ..Malfunction of the Fas system causes lymphoproliferative disorders and accelerates autoimmune diseases, whereas its exacerbation may cause tissue destruction...
  8. ncbi A gene encoding an antigen recognized by cytolytic T lymphocytes on a human melanoma
    P van der Bruggen
    Ludwig Institute for Cancer Research, Brussels, Belgium
    Science 254:1643-7. 1991
    ..Thus, precisely targeted immunotherapy directed against antigen MZ2-E could be provided to individuals identified by HLA typing and analysis of the RNA of a small tumor sample...
  9. ncbi Natural selection of tumor variants in the generation of "tumor escape" phenotypes
    Hung T Khong
    National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Nat Immunol 3:999-1005. 2002
    ..Tumor escape variants are likely to emerge after treatment with increasingly effective immunotherapies...
  10. ncbi Control of viremia in simian immunodeficiency virus infection by CD8+ lymphocytes
    J E Schmitz
    Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Science 283:857-60. 1999
    ..These results confirm the importance of cell-mediated immunity in controlling HIV-1 infection and support the exploration of vaccination approaches for preventing infection that will elicit these immune responses...
  11. ncbi Cross-presentation: underlying mechanisms and role in immune surveillance
    Kenneth L Rock
    Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Immunol Rev 207:166-83. 2005
    ..In addition to the critical role of cross-presentation in normal immune physiology, this pathway has considerable potential for being exploited for developing subunit vaccines that elicit both CD4(+) and CD8(+) T-cell immunity...
  12. ncbi Analysis of a successful immune response against hepatitis C virus
    S Cooper
    Department of Structural Biology, Stanford University School of Medicine, California 94305 5400, USA
    Immunity 10:439-49. 1999
    ..Every specificity shown during acute hepatitis persisted in normal liver tissue more than 1 yr after resolution. These results suggest that CD8+CTL are better correlated with protection against HCV infection than antibodies...
  13. ncbi Distinct migrating and nonmigrating dendritic cell populations are involved in MHC class I-restricted antigen presentation after lung infection with virus
    Gabrielle T Belz
    Division of Immunology, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia
    Proc Natl Acad Sci U S A 101:8670-5. 2004
    ..Presentation by a nonairway-derived DC population argues that cytotoxic T lymphocyte priming may involve interplay between different DC subsets, not all of which originate within the site of infection...
  14. ncbi Melanoma cell expression of Fas(Apo-1/CD95) ligand: implications for tumor immune escape
    M Hahne
    Institute of Biochemistry, University of Lausanne, CH 1066 Epalinges, Switzerland
    Science 274:1363-6. 1996
    ..In contrast, tumorigenesis was delayed in Fas-deficient lpr mutant mice in which immune effector cells cannot be killed by FasL. Thus, FasL may contribute to the immune privilege of tumors...
  15. ncbi Antigen processing influences HIV-specific cytotoxic T lymphocyte immunodominance
    Stefan Tenzer
    Institute of Immunology, University of Mainz, Mainz, Germany
    Nat Immunol 10:636-46. 2009
    Although cytotoxic T lymphocytes (CTLs) in people infected with human immunodeficiency virus type 1 can potentially target multiple virus epitopes, the same few are recognized repeatedly...
  16. ncbi Cell therapy of stage IV nasopharyngeal carcinoma with autologous Epstein-Barr virus-targeted cytotoxic T lymphocytes
    Patrizia Comoli
    Laboratorio di Ricerca Area Trapianti e Oncoematologia Pediatrica, IRCCS Policlinico S Matteo, V le Golgi 19, 27100 Pavia, Italy
    J Clin Oncol 23:8942-9. 2005
    ..We conducted a clinical trial of EBV-targeted cell therapy with autologous virus-specific cytotoxic T lymphocytes (CTLs) for NPC refractory to conventional treatments.
  17. ncbi A structural basis for the selection of dominant alphabeta T cell receptors in antiviral immunity
    Lars Kjer-Nielsen
    Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria 3010, Australia
    Immunity 18:53-64. 2003
    ..These findings indicate that TCR immunodominance is associated with structural properties conferring receptor specificity and suggest a novel structural link between TCR ligation and intracellular signaling...
  18. ncbi Structural and functional constraints limit options for cytotoxic T-lymphocyte escape in the immunodominant HLA-B27-restricted epitope in human immunodeficiency virus type 1 capsid
    Arne Schneidewind
    Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Virol 82:5594-605. 2008
    ....
  19. ncbi Idiotype-specific cytotoxic T lymphocytes in multiple myeloma: evidence for their capacity to lyse autologous primary tumor cells
    Y J Wen
    Myeloma and Transplantation Research Center, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Blood 97:1750-5. 2001
    ..Taken together, these findings represent the first demonstration that Id-specific CTLs are able to lyse autologous tumor cells in MM and, thus, provide a rationale for Id-based immunotherapy in the disease...
  20. ncbi HIV-1 viral escape in infancy followed by emergence of a variant-specific CTL response
    Margaret E Feeney
    Partners AIDS Research Center and Infectious Disease Division, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Immunol 174:7524-30. 2005
    ..Taken together, these findings indicate that the developing immune system of children may exhibit greater plasticity in responding to a continually evolving chronic viral infection...
  21. ncbi Differential T cell costimulatory requirements in CD28-deficient mice
    A Shahinian
    Department of Medical Biophysics and Immunology, University of Toronto, Canada
    Science 261:609-12. 1993
    ..Thus, CD28 is not required for all T cell responses in vivo, suggesting that alternative costimulatory pathways may exist...
  22. ncbi Cytotoxic T lymphocytes in autoimmune and degenerative CNS diseases
    Harald Neumann
    Neuroimmunology Unit, European Neuroscience Institute Göttingen, Waldweg 33, 37073 Gottingen, Germany
    Trends Neurosci 25:313-9. 2002
    b>Cytotoxic T lymphocytes (CTLs) with a CD8(+) phenotype have the potential to recognize and attack major histocompatibility complex (MHC) class I-expressing brain cells...
  23. ncbi Prospects for an influenza vaccine that induces cross-protective cytotoxic T lymphocytes
    Lorena E Brown
    Department of Microbiology and Immunology, The University of Melbourne, Parkville, Victoria, Australia
    Immunol Cell Biol 87:300-8. 2009
    ..and those with the potential to cause a pandemic share amino acid sequences that form the targets of cytotoxic T lymphocytes (CTL)...
  24. ncbi In vivo high resolution three-dimensional imaging of antigen-specific cytotoxic T-lymphocyte trafficking to tumors
    Moritz F Kircher
    Center for Molecular Imaging Research, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Cancer Res 63:6838-46. 2003
    ..CD8+ cytotoxic T lymphocytes labeled with CLIO-HD were detectable via MRI with a detection threshold of 2 cells/voxel in vitro and ..
  25. ncbi Phase I study of adoptive T-cell therapy using antigen-specific CD8+ T cells for the treatment of patients with metastatic melanoma
    Andreas Mackensen
    Department of Hematology Oncology, University of Regensburg, Franz Josef Strauss Allee 11, D 93042 Regensburg, Germany
    J Clin Oncol 24:5060-9. 2006
    The adoptive transfer of in vitro generated tumor antigen-specific cytotoxic T lymphocytes (CTL) provides a promising approach to the immunotherapy of cancer...
  26. ncbi A prospective study demonstrates an association between JC virus-specific cytotoxic T lymphocytes and the early control of progressive multifocal leukoencephalopathy
    Renaud A Du Pasquier
    Division of ViralPathogenesis Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Brain 127:1970-8. 2004
    ..In previous studies, we showed that JCV-specific cytotoxic T lymphocytes (JCV-specific CTL) were associated with a favourable outcome in patients with PML...
  27. ncbi Induction of HM1.24 peptide-specific cytotoxic T lymphocytes by using peripheral-blood stem-cell harvests in patients with multiple myeloma
    Ali Jalili
    Department of Medicine and Bioregulatory Sciences, Institute of Health Biosciences, University of Tokushima Graduate School, Japan
    Blood 106:3538-45. 2005
    ..The ability of these peptides to generate cytotoxic T lymphocytes (CTLs) was examined in 20 healthy donors and 6 patients with MM by a reverse immunologic approach...
  28. ncbi HV-1-specific cytotoxic T lymphocytes and breast milk HIV-1 transmission
    Grace C John-Stewart
    Department of Paediatrics, University of Nairobi, Nairobi, Kenya
    J Infect Dis 199:889-98. 2009
    ....
  29. ncbi Human papillomavirus type 16 (HPV-16) virus-like particle L1-specific CD8+ cytotoxic T lymphocytes (CTLs) are equally effective as E7-specific CD8+ CTLs in killing autologous HPV-16-positive tumor cells in cervical cancer patients: implications for L1 den
    Stefania Bellone
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut 06520 8063, USA
    J Virol 83:6779-89. 2009
    ..expressed strong cytolytic activity against autologous tumor cells and were as effective as E7-specific cytotoxic T lymphocytes in lysing naturally HPV-16-infected autologous tumor cells...
  30. ncbi Intratumoral balance of regulatory and cytotoxic T cells is associated with prognosis of hepatocellular carcinoma after resection
    Qiang Gao
    Liver Cancer Institute, Zhong Shan Hospital and Shanghai Medical School, Fudan University, Key Laboratory for Carcinogenesis and Cancer Invasion, the Chinese Ministry of Education, Shanghai, People s Republic of China
    J Clin Oncol 25:2586-93. 2007
    ..To investigate the prognostic value of tumor-infiltrating lymphocytes (TILs), especially regulatory T cells (Tregs), in hepatocellular carcinoma (HCC) patients after resection...
  31. ncbi TGF-beta directly targets cytotoxic T cell functions during tumor evasion of immune surveillance
    Dori A Thomas
    Cancer Biology and Genetics Program and Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Cancer Cell 8:369-80. 2005
    ..We demonstrate that TGF-beta acts on cytotoxic T lymphocytes (CTLs) to specifically inhibit the expression of five cytolytic gene products-namely, perforin, granzyme ..
  32. ncbi The generation and characterization of LMP2-specific CTLs for use as adoptive transfer from patients with relapsed EBV-positive Hodgkin disease
    Catherine M Bollard
    Center for Cell and Gene Therapy, Baylor College of Medicine, The Methodist Hospital and Texas Children s Hospital, Houston, Texas 77030, USA
    J Immunother 27:317-27. 2004
    ..The authors aimed to generate cytotoxic T lymphocytes (CTLs) from patients with relapsed HD by specifically targeting LMP2A...
  33. ncbi Adoptive cellular therapy for early cytomegalovirus infection after allogeneic stem-cell transplantation with virus-specific T-cell lines
    Karl S Peggs
    Royal Free and University College London Medical School, London, UK
    Lancet 362:1375-7. 2003
    ..Massive in-vivo expansions of CMV-specific cytotoxic T lymphocytes were observed, resulting in reconstitution of viral immunity...
  34. ncbi The role of the proteasome in generating cytotoxic T-cell epitopes: insights obtained from improved predictions of proteasomal cleavage
    Morten Nielsen
    Center for Biological Sequence Analysis, Technical University of Denmark, BioCentrum DTU, Building 208, 2800, Lyngby, Denmark
    Immunogenetics 57:33-41. 2005
    ..e., the specificity of TAP has evolved to fit the specificity of the proteasome. This evolutionary relationship allows for a more efficient antigen presentation...
  35. ncbi Tumor lysate-specific cytotoxic T lymphocytes in multiple myeloma: promising effector cells for immunotherapy
    Yue-Jin Wen
    Myeloma and Transplantation Research Center, University of Arkansas for Medical Science, Little Rock 72205, USA
    Blood 99:3280-5. 2002
    ..immunotherapy, the current study was undertaken to generate and examine the function of myeloma-specific cytotoxic T lymphocytes (CTLs) by using dendritic cells (DCs) pulsed with myeloma cell lysates as stimulating cells...
  36. ncbi Control of viremia and prevention of clinical AIDS in rhesus monkeys by cytokine-augmented DNA vaccination
    D H Barouch
    Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
    Science 290:486-92. 2000
    With accumulating evidence indicating the importance of cytotoxic T lymphocytes (CTLs) in containing human immunodeficiency virus-1 (HIV-1) replication in infected individuals, strategies are being pursued to elicit virus-specific CTLs ..
  37. ncbi Increased CD95/Fas-induced apoptosis of HIV-specific CD8(+) T cells
    Y M Mueller
    Department of Microbiology and Immunology, MCP Hahnemann University, Philadelphia, Pennsylvania 19129, USA
    Immunity 15:871-82. 2001
    ..Our data suggest that the survival and differentiation of HIV-specific CD8(+) T cells may be compromised by CD95/Fas apoptosis induced by FasL-expressing HIV-infected cells...
  38. ncbi Ex vivo induction of multiple myeloma-specific cytotoxic T lymphocytes
    Toshiaki Hayashi
    Jerome Lipper Multiple Myeloma Center, Department of Medical Oncology, Dana-Farber Cancer Institute, 44 Binney St, Boston, MA 02115, USA
    Blood 102:1435-42. 2003
    ..sera inhibiting autologous anti-MM immunity and developed an ex vivo strategy for inducing MM-specific cytotoxic T lymphocytes (CTLs)...
  39. ncbi Critical role of cytotoxic T lymphocytes in immune clearance of rickettsial infection
    D H Walker
    Department of Pathology and WHO Collaborating Center for Tropical Diseases, University of Texas Medical Branch, Galveston, Texas 77555 0609, USA
    Infect Immun 69:1841-6. 2001
    ..CTLs appear to be crucial to recovery from rickettsial infection...
  40. ncbi Blocking chemokine responsive to gamma-2/interferon (IFN)-gamma inducible protein and monokine induced by IFN-gamma activity in vivo reduces the pathogenetic but not the antiviral potential of hepatitis B virus-specific cytotoxic T lymphocytes
    K Kakimi
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Exp Med 194:1755-66. 2001
    ..mice that replicate hepatitis B virus (HBV) at high levels in the liver as recipients of HBV-specific cytotoxic T lymphocytes (CTLs), we showed that the chemokines responsive to gamma-2/IFN-gamma inducible protein ([Crg2]IP-10) and ..
  41. ncbi Immune escape of tumors in vivo by expression of cellular FLICE-inhibitory protein
    J P Medema
    Department of Immunohematology and Bloodbank, Leiden University Medical Center, 2333AA Leiden, The Netherlands
    J Exp Med 190:1033-8. 1999
    ....
  42. ncbi Portable flanking sequences modulate CTL epitope processing
    Sylvie Le Gall
    Partners AIDS Research Center and Howard Hughes Medical Institute, Massachusetts General Hospital MGH, Harvard Medical School, Boston, Massachusetts 02129, USA
    J Clin Invest 117:3563-75. 2007
    ..Such portable epitope processing determinants provide what we believe is a novel approach to optimizing CTL responses elicited by vaccine vectors...
  43. ncbi Plasma cells from multiple myeloma patients express B7-H1 (PD-L1) and increase expression after stimulation with IFN-{gamma} and TLR ligands via a MyD88-, TRAF6-, and MEK-dependent pathway
    Jizhong Liu
    Institut National de la Sante et de la Recherche Medicale, Unité 837, Institut de Recherche sur le Cancer de Lille, France
    Blood 110:296-304. 2007
    ..MM plasma cells stimulated with IFN-gamma or TLR ligands inhibited cytotoxic T lymphocytes (CTLs) generation and this immunosuppressive effect was inhibited by preincubation with an anti-B7-H1 ..
  44. ncbi Cloning of a T cell growth factor that interacts with the beta chain of the interleukin-2 receptor
    K H Grabstein
    Immunex Research and Development Corporation, Seattle, WA 98101
    Science 264:965-8. 1994
    ..Monoclonal antibodies to the beta chain of the IL-2 receptor inhibited the biological activity of IL-15, and IL-15 competed for binding with IL-2, indicating that IL-15 uses components of the IL-2 receptor...
  45. ncbi Noninvasive detection of therapeutic cytolytic T cells with 18F-FHBG PET in a patient with glioma
    Shahriar S Yaghoubi
    Multimodality Molecular Imaging Lab, Department of Radiology and Bioengineering, Stanford University, Stanford, CA, USA
    Nat Clin Pract Oncol 6:53-8. 2009
    ....
  46. ncbi A role for the proteasome regulator PA28alpha in antigen presentation
    M Groettrup
    Institute for Biochemistry, Medical Faculty Charité, Humboldt University, Berlin, Germany
    Nature 381:166-8. 1996
    ..These results demonstrate a fundamental in vivo function for PA28alpha in antigen processing...
  47. ncbi Estimation of the rate of killing by cytotoxic T lymphocytes in vivo
    Roland R Regoes
    Department of Biology, Emory University, Atlanta, GA 30322, USA
    Proc Natl Acad Sci U S A 104:1599-603. 2007
    b>Cytotoxic T lymphocytes (CTL) help control virus infections by killing virus-infected (target) cells...
  48. ncbi Theileria parva candidate vaccine antigens recognized by immune bovine cytotoxic T lymphocytes
    Simon P Graham
    International Livestock Research Institute, Nairobi, Kenya
    Proc Natl Acad Sci U S A 103:3286-91. 2006
    ..Schizont-infected cell-directed CD8(+) cytotoxic T lymphocytes (CTL) constitute the dominant protective bovine immune response after a single exposure to infection...
  49. ncbi Human and mouse granzyme A induce a proinflammatory cytokine response
    Sunil S Metkar
    Department of Medicine, NorthShore University HealthSystem Research Institute, Evanston, IL 60201, USA
    Immunity 29:720-33. 2008
    ..Moreover, murine GzmA and GzmA(+) cytotoxic T lymphocytes (CTLs) induce IL-1beta from primary mouse macrophages, and GzmA(-/-) mice resist lipopolysaccharide-..
  50. ncbi Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells
    Susanne J Szabo
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    Science 295:338-42. 2002
    ..This difference is also apparent in the function of these cell subsets. Thus, the regulation of a single cytokine, IFN-gamma, is controlled by distinct transcriptional mechanisms within the T cell lineage...
  51. ncbi Effector and memory CTL differentiation
    Matthew A Williams
    Howard Hughes Medical Institute, Department of Immunology, University of Washington, Seattle, Washington 98195, USA
    Annu Rev Immunol 25:171-92. 2007
    ..models have all facilitated more precise and definitive analyses of the generation and function of cytotoxic T lymphocytes (CTL)...
  52. ncbi Functional significance of the perforin/granzyme cell death pathway
    Joseph A Trapani
    Cancer Immunology Laboratory, Trescowthick Research Laboratories, Research Division, Peter MacCallum Cancer Institute, Locked Bag 1, A Beckett Street, Melbourne 8006, Australia
    Nat Rev Immunol 2:735-47. 2002
    ....
  53. ncbi Toward an AIDS vaccine
    Bruce D Walker
    Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA
    Science 320:760-4. 2008
    ....
  54. ncbi Sublethal irradiation of human tumor cells modulates phenotype resulting in enhanced killing by cytotoxic T lymphocytes
    Charlie T Garnett
    Laboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892-1750, USA
    Cancer Res 64:7985-94. 2004
    ....
  55. ncbi Characterization of CD4(+) CTLs ex vivo
    Victor Appay
    Medical Research Council Human Immunology Unit, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, United Kingdom
    J Immunol 168:5954-8. 2002
    ..The existence of CD4(+) cytotoxic T cells in vivo at relatively high levels in chronic viral infection suggests a role in the immune response...
  56. ncbi In vivo depletion of CD11c+ dendritic cells abrogates priming of CD8+ T cells by exogenous cell-associated antigens
    Steffen Jung
    Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York 10016, USA
    Immunity 17:211-20. 2002
    b>Cytotoxic T lymphocytes (CTL) respond to antigenic peptides presented on MHC class I molecules. On most cells, these peptides are exclusively of endogenous, cytosolic origin...
  57. ncbi Protective immunity does not correlate with the hierarchy of virus-specific cytotoxic T cell responses to naturally processed peptides
    A Gallimore
    Institute of Experimental Immunology, CH 8091 Zurich, Switzerland
    J Exp Med 187:1647-57. 1998
    ..This report, therefore, indicates that immunodominant epitopes should be defined, not only by the strength of the CTL response that they stimulate, but also by the ability of the CTLs to protect against infection...
  58. ncbi Contrasting frequencies of antitumor and anti-vaccine T cells in metastases of a melanoma patient vaccinated with a MAGE tumor antigen
    Christophe Lurquin
    Cellular Genetics Unit, , B-1200 Brussels, Belgium
    J Exp Med 201:249-57. 2005
    ..Naive T cells appear to be stimulated in the course of this process as new antitumor clonotypes arise after vaccination...
  59. ncbi Characterization of an antigen that is recognized on a melanoma showing partial HLA loss by CTL expressing an NK inhibitory receptor
    H Ikeda
    Cellular Genetics Unit, Universite Catholique de Louvain, Brussels, Belgium
    Immunity 6:199-208. 1997
    ....
  60. ncbi Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade
    Yoshiko Iwai
    Department of Medical Chemistry, Graduate School of Medicine, Japan Science and Technology Corporation, Kyoto 606 8501, Japan
    Proc Natl Acad Sci U S A 99:12293-7. 2002
    ....
  61. ncbi The epitopes of influenza nucleoprotein recognized by cytotoxic T lymphocytes can be defined with short synthetic peptides. 1986
    A R M Townsend
    J Immunol 176:5141-50. 2006
  62. ncbi Identification of vaccine candidate peptides in the NcSRS2 surface protein of Neospora caninum by using CD4+ cytotoxic T lymphocytes and gamma interferon-secreting T lymphocytes of infected holstein cattle
    Lauren M Staska
    Department of Veterinary Microbiology and Pathology, Bustad Hall, Washington State University, Pullman, WA 99164-7040, USA
    Infect Immun 73:1321-9. 2005
    ..showed that Holstein cattle experimentally infected with Neospora caninum develop parasite-specific CD4+ cytotoxic T lymphocytes (CTL) that lyse infected, autologous target cells through a perforin-granzyme pathway...
  63. ncbi Cytotoxic CD4+ T cells use granulysin to kill Cryptococcus neoformans, and activation of this pathway is defective in HIV patients
    Chun Fu Zheng
    Department of Microbiology and Infectious Disease, University of Calgary, AB, Canada
    Blood 109:2049-57. 2007
    ..These cells use granulysin as the effector molecule, and priming is dysregulated in HIV-infected patients, which results in defective microbicidal activity...
  64. ncbi Interleukin-2 and inflammation induce distinct transcriptional programs that promote the differentiation of effector cytolytic T cells
    Matthew E Pipkin
    Harvard Medical School, Boston, MA 02115, USA Immune Disease Institute, Boston, MA 02115, USA
    Immunity 32:79-90. 2010
    ..Thus, inflammation influences both effector and memory CTL differentiation, whereas persistent IL-2 stimulation promotes effector at the expense of memory CTL development...
  65. ncbi Granule exocytosis, and not the fas/fas ligand system, is the main pathway of cytotoxicity mediated by alloantigen-specific CD4(+) as well as CD8(+) cytotoxic T lymphocytes in humans
    M Yasukawa
    First Department of Internal Medicine, Ehime University School of Medicine, Shigenobu, Ehime
    Blood 95:2352-5. 2000
    We investigated the cytotoxicity mechanisms of alloantigen-specific human CD4(+) and CD8(+) cytotoxic T lymphocytes (CTLs) using cells from family members with the Fas gene mutation...
  66. ncbi Cytotoxic T lymphocyte therapy for Epstein-Barr virus+ Hodgkin's disease
    Catherine M Bollard
    Center for Gene and Cell Therapy, Baylor College of Medicine, 6621 Fannin St, MC 3 3320, Houston, TX 77030, USA
    J Exp Med 200:1623-33. 2004
    ..One additional patient had a partial response, and five had stable disease. The performance and fate of these human tumor antigen-specific T cells in vivo suggests that they might be of value for the treatment of EBV+ Hodgkin lymphoma...
  67. ncbi Antigen-specific cytotoxic T lymphocytes can target chemoresistant side-population tumor cells in Hodgkin lymphoma
    Jessica A Shafer
    Center for Cell and Gene Therapy, Department of Pediatrics, Baylor College of Medicine, The Methodist Hospital and Texas Children s Cancer Center, Houston, TX 77030, USA
    Leuk Lymphoma 51:870-80. 2010
    ..SSX2, survivin, and NY-ESO-1, which allowed them to be specifically recognized and killed by TAA-specific cytotoxic T lymphocytes. This study suggests that chemoresistant HL SP cells can be targeted by the immune system, providing a ..
  68. ncbi Identification of ribosomal protein L19 as a novel tumor antigen recognized by autologous cytotoxic T lymphocytes in lung adenocarcinoma
    Koji Kuroda
    Second Department of Surgery, University of Occupational and Environmental Health, Kitakyushu, Japan
    Cancer Sci 101:46-53. 2010
    ..autologous lung adenocarcinoma cell line H1224L resulted in a successful induction of bulk cytotoxic T lymphocytes (CTL)...
  69. ncbi Cytotoxic T lymphocytes: all roads lead to death
    Michele Barry
    Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Canada
    Nat Rev Immunol 2:401-9. 2002
    b>Cytotoxic T lymphocytes (CTLs) provide potent defences against virus infection and intracellular pathogens...
  70. ncbi Multipotent adult germ-line stem cells, like other pluripotent stem cells, can be killed by cytotoxic T lymphocytes despite low expression of major histocompatibility complex class I molecules
    Ralf Dressel
    Department of Cellular and Molecular Immunology, University of Gottingen, Heinrich Düker Weg 12, 37073 Gottingen, Germany
    Biol Direct 4:31. 2009
    ..these stem cells can be rejected by the recipients, we have analyzed whether maGSCs and iPSCs can become targets for cytotoxic T lymphocytes (CTL) or whether they are protected, as previously proposed for embryonic stem cells (ESCs).
  71. ncbi Enhancement of anti-tumor immunity by high levels of Th1 and Th17 with a combination of dendritic cell fusion hybrids and regulatory T cell depletion in pancreatic cancer
    Masashi Yamamoto
    Department of Surgery, Kobe University Graduate School of Medicine, Hyogo 650 0017, Japan
    Oncol Rep 22:337-43. 2009
    ..These results demonstrate that Treg depletion combined with DC/TC fusion hybrid vaccine enhanced the efficacy of immunotherapy in pancreatic cancer by activating CTLs and NK cells...
  72. ncbi Two new tumor-specific antigenic peptides encoded by gene MAGE-C2 and presented to cytolytic T lymphocytes by HLA-A2
    Wenbin Ma
    Ludwig Institute for Cancer Research, Brussels Branch, Avenue Hippocrate 74, UCL 7459, B 1200 Brussels, Belgium
    Int J Cancer 109:698-702. 2004
    ..The CTL clones recognizing these 2 peptides also recognized allogeneic tumor cell lines expressing MAGE-C2 and HLA-A2. These 2 new peptides are the first known MAGE-C antigens and represent promising targets for cancer immunotherapy...
  73. ncbi Major histocompatibility complex class I alleles associated with slow simian immunodeficiency virus disease progression bind epitopes recognized by dominant acute-phase cytotoxic-T-lymphocyte responses
    Bianca R Mothe
    Wisconsin Regional Primate Research Center and Department of Pathology and Laboratory Medicine, Madison, Wisconsin, USA
    J Virol 77:9029-40. 2003
    ....
  74. ncbi Comparison of protective efficacies of plasmid DNAs encoding Japanese encephalitis virus proteins that induce neutralizing antibody or cytotoxic T lymphocytes in mice
    Eiji Konishi
    Department of Health Sciences, Kobe University School of Medicine, 7 10 2 Tomogaoka, Suma ku, Kobe 654 0142, Japan
    Vaccine 21:3675-83. 2003
    ..b>Cytotoxic T lymphocytes (CTLs) were induced by plasmids encoding capsid (C) or nonstructural proteins, NS1, NS2A, NS2B, NS3 or ..
  75. ncbi Feasibility of immunotherapy of relapsed leukemia with ex vivo-generated cytotoxic T lymphocytes specific for hematopoietic system-restricted minor histocompatibility antigens
    T Mutis
    Department of Immunohematology and Blood Bank, Leiden University Medical Center, Leiden, The Netherlands
    Blood 93:2336-41. 1999
    ..Recurrence of the underlying malignancy is a major cause of treatment failure. Donor-derived cytotoxic T lymphocytes (CTLs) specific for patients' minor histocompatibility antigens (mHags) play an important role in both ..
  76. ncbi Epstein Barr virus specific cytotoxic T lymphocytes expressing the anti-CD30zeta artificial chimeric T-cell receptor for immunotherapy of Hodgkin disease
    Barbara Savoldo
    Center for Cell and Gene Therapy, Baylor College of Medicine, The Methodist Hospital and Texas Children s Hospital, Houston, TX 77030, USA
    Blood 110:2620-30. 2007
    ..EBV-CTLs expressing both a native and a chimeric antigen receptor may therefore have added value for treatment of HD...
  77. ncbi Centrosome polarization delivers secretory granules to the immunological synapse
    Jane C Stinchcombe
    Sir William Dunn School of Pathology, South Parks Road, Oxford OX1 3RE, UK
    Nature 443:462-5. 2006
    b>Cytotoxic T lymphocytes (CTLs) destroy virally infected and tumorigenic cells by releasing the contents of specialized secretory lysosomes--termed 'lytic granules'--at the immunological synapse formed between the CTL and the target...
  78. ncbi Interleukin-2-induced, melanoma-specific T cells recognize CAMEL, an unexpected translation product of LAGE-1
    C A Aarnoudse
    Department of Clinical Oncology, Leiden University Medical Center, The Netherlands
    Int J Cancer 82:442-8. 1999
    Melanoma-specific cytotoxic T lymphocytes (CTLs) were induced by in vitro stimulation of peripheral blood mononuclear cells of a melanoma patient with autologous IL-2-producing melanoma 518/IL2.14 cells...
  79. ncbi CTL quality and the control of human retroviral infections
    Charles R M Bangham
    Department of Immunology, Imperial College, London, UK
    Eur J Immunol 39:1700-12. 2009
    ..e. in the frequency, phenotype and function or quality of T cells, are the causes or effects - or both - of the variation in the efficiency of virus control...
  80. ncbi Effects of cytotoxic T lymphocytes (CTL) directed against a single simian immunodeficiency virus (SIV) Gag CTL epitope on the course of SIVmac239 infection
    Todd M Allen
    Wisconsin Regional Primate Research Center, University of Wisconsin, Madison, WI 53715, USA
    J Virol 76:10507-11. 2002
    Vaccine-induced cytotoxic T lymphocytes (CTL) have been implicated in the control of virus replication in simian immunodeficiency virus (SIV)-challenged and simian-human immunodeficiency virus-challenged macaques...
  81. ncbi Neospora caninum-infected cattle develop parasite-specific CD4+ cytotoxic T lymphocytes
    Lauren M Staska
    Department of Veterinary Microbiology and Pathology, Washington State University, Pullman 99164, USA
    Infect Immun 71:3272-9. 2003
    ..b>Cytotoxic T lymphocytes (CTL) are important mediators of protective immunity against Toxoplasma gondii, an intracellular ..
  82. ncbi Gene vaccines
    Indresh K Srivastava
    Ann Intern Med 138:550-9. 2003
    ..Preclinical and clinical studies of these vaccines are discussed for various clinical applications, focusing on infectious diseases...
  83. ncbi Loss of cytotoxic T lymphocyte function in Chediak-Higashi syndrome arises from a secretory defect that prevents lytic granule exocytosis
    K Baetz
    Basel Institute for Immunology, Switzerland
    J Immunol 154:6122-31. 1995
    ..We suggest that the defect in CHS lies in a protein that is involved in membrane fusion and is essential for the secretion of lysosomal compartments in certain hemopoietic cells...
  84. ncbi Autologous dendritic cells transfected with prostate-specific antigen RNA stimulate CTL responses against metastatic prostate tumors
    Axel Heiser
    Cancer Immunotherapy Program, Division of Urology, Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Clin Invest 109:409-17. 2002
    ....
  85. ncbi A comparison of two types of dendritic cell as adjuvants for the induction of melanoma-specific T-cell responses in humans following intranodal injection
    H Jonuleit
    Department of Dermatology, University of Mainz, Langenbeckstrasse 1, 55101 Mainz, Germany
    Int J Cancer 93:243-51. 2001
    ..Thus, our data define FCS-free cultured mature DCs as superior inducers of T-cell responses in melanoma patients...
  86. ncbi The flexibility of the TCR allows recognition of a large set of naturally occurring epitope variants by HIV-specific cytotoxic T lymphocytes
    F Buseyne
    Laboratoire d'Immunopathologie Virale, URA CNRS 1930, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
    Int Immunol 13:941-50. 2001
    ..This flexibility of the TCR is probably of great importance for control of viruses with high genetic variability, such as HIV...
  87. ncbi Cutting edge: rapid and efficient in vivo cytotoxicity by cytotoxic T cells is independent of granzymes A and B
    Matthias Regner
    John Curtin School of Medical Research, Canberra, Australia
    J Immunol 183:37-40. 2009
    ..Specific target cell elimination occurred with similar kinetics in both spleen and lymph nodes. Thus, neither gzmA nor gzmB are required for rapid and efficient in vivo cytotoxicity by Tc cells...
  88. ncbi Human immunodeficiency virus type 1-specific CD8+ T-cell responses during primary infection are major determinants of the viral set point and loss of CD4+ T cells
    Hendrik Streeck
    Ragon Institute of MGH, MIT, and Harvard, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA
    J Virol 83:7641-8. 2009
    ..Taken together, these data show that the specificity of the initial CTL response to HIV is critical for the subsequent control of viremia and have important implications for the rational selection of antigens for future HIV-1 vaccines...
  89. ncbi Beta 2-microglobulin deficient mice lack CD4-8+ cytolytic T cells
    M Zijlstra
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts
    Nature 344:742-6. 1990
    ....
  90. ncbi Peptide epitopes from the Wilms' tumor 1 oncoprotein stimulate CD4+ and CD8+ T cells that recognize and kill human malignant mesothelioma tumor cells
    Rena J May
    Molecular Pharmacology and Chemistry Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Clin Cancer Res 13:4547-55. 2007
    ..The induction and maintenance of a robust memory CD8(+) cytotoxic T-cell response requires CD4(+) T-cell help...
  91. ncbi Generating p53-specific cytotoxic T lymphocytes by recombinant adenoviral vector-based vaccination in mice, but not man
    J Kuball
    Department of Hematology and Oncology, Johannes Gutenberg-University, Mainz, Germany
    Gene Ther 9:833-43. 2002
    ..The generation of p53 epitope-specific cytotoxic T lymphocytes (CTLs) in p53-proficient and p53-deficient A2K(b)-Tg mice was affected by self-tolerance and a selective ..
  92. ncbi Synthetic peptides coupled to the surface of liposomes effectively induce SARS coronavirus-specific cytotoxic T lymphocytes and viral clearance in HLA-A*0201 transgenic mice
    Satoshi Ohno
    Department of Microbiology, Faculty of Medicine, Saitama Medical University, Iruma gun, Saitama 350 0495, Japan
    Vaccine 27:3912-20. 2009
    We investigated whether the surface-linked liposomal peptide was applicable to a vaccine based on cytotoxic T lymphocytes (CTLs) against severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV)...
  93. ncbi Endoplasmic reticulum targeting sequence enhances HBV-specific cytotoxic T lymphocytes induced by a CTL epitope-based DNA vaccine
    Wei Xu
    Department of Immunology, Shanghai Medical College of Fudan University, Shanghai, PR China
    Virology 334:255-63. 2005
    ..DNA vaccines expressing HBV-dominant CTL epitopes can be used as candidate vaccines capable of inducing cytotoxic T Lymphocytes (CTL) responses. A plasmid DNA encoding a CTL epitope of HBV core antigen, HBc(18-27), was constructed...
  94. ncbi Cytotoxic T cells reactive to an immunodominant leukemia-associated antigen can be specifically primed and expanded by combining a specific priming step with nonspecific large-scale expansion
    Arnab Ghosh
    Transplantationsforschungszentrum, Department of Pediatric Hematology Oncology Medizinische Hochschule Hannover, Germany
    J Immunother 31:121-31. 2008
    ..However, increasing the leukemia-reactive precursor frequency to a clinically exploitable level will be the key for the design of successful T-cell therapy trials...
  95. ncbi Electroporation as a "prime/boost" strategy for naked DNA vaccination against a tumor antigen
    Sarah Buchan
    Molecular Immunology Group, Southampton University Hospitals Trust, Southampton, United Kingdom
    J Immunol 174:6292-8. 2005
    ..Therefore, boosting may not require viral vectors, but simply a physical change in delivery, facilitating application to the cancer clinic...
  96. ncbi Monocyte-derived dendritic cells generated after a short-term culture with IFN-alpha and granulocyte-macrophage colony-stimulating factor stimulate a potent Epstein-Barr virus-specific CD8+ T cell response
    Laura Santodonato
    Laboratory of Virology, Istituto Superiore di Sanit, Rome, Italy
    J Immunol 170:5195-202. 2003
    ..Our results indicate that IFN-DCs efficiently promote in vitro and in vivo the expansion of CD8(+) T lymphocytes acting as cytotoxic effectors against EBV-transformed cells...
  97. ncbi alpha-fetoprotein and interleukin-18 gene-modified dendritic cells effectively stimulate specific type-1 CD4- and CD8-mediated T-Cell response from hepatocellular carcinoma patients in Vitro
    Da Yong Cao
    Department of Hepatobiliary Surgery, Xijing Hospital, Fourth Military Medical University, Shaanxi Province, China
    Hum Immunol 68:334-41. 2007
    ....
  98. ncbi Transfection of dendritic cells with RNA induces CD4- and CD8-mediated T cell immunity against breast carcinomas and reveals the immunodominance of presented T cell epitopes
    Martin R Muller
    Department of Hematology, Oncology, and Immunology, University of Tubingen, Tubingen, Germany
    J Immunol 170:5892-6. 2003
    ..The induced Th cells were found to be entirely HLA class II restricted and showed a significant cross-reactivity to a renal cell carcinoma cell line, similar to the results obtained with cytotoxic T cells...
  99. ncbi TACI-BLyS signaling via B-cell-dendritic cell cooperation is required for naive CD8+ T-cell priming in vivo
    Yaiza Diaz-De-Durana
    Torrey Pines Institute for Molecular Studies, San Diego, CA, USA
    Blood 107:594-601. 2006
    ....
  100. ncbi Intramuscular immunization with plasmid coexpressing tumour antigen and Flt-3L results in potent tumour regression
    C L Fong
    Division of Cellular and Molecular Research, National Cancer Centre, Singapore
    Gene Ther 13:245-56. 2006
    ..However, systemic expansion of DC prior to immunization did not enhance the specific cellular response, suggesting that it is in situ recruitment or expansion of DC that is critical for pNGVL-hFLex-MUC-1 potency...
  101. ncbi Generation of cytotoxic responses in mice and human individuals against hematological malignancies using survivin-RNA-transfected dendritic cells
    Matthias Zeis
    General Hospital St Georg, Hamburg, Germany
    J Immunol 170:5391-7. 2003
    ..Our data provide evidence for the use of survivin as a target structure for immunotherapeutic strategies against hematological neoplasms...

Research Grants89

  1. Identification of biomarkers of fatty acid intake
    Hannia Campos; Fiscal Year: 2002
    ..toxicity, and efficacy of treating patients with relapsed follicular lymphomas with autologous CD8+ cytotoxic T lymphocytes (CTL) which have been genetically modified to express a chimeric T cell receptor recognizing the CD20 ..
  2. CHARACTERIZATION OF THE MURINE COMPLEMENT RECEPTORS
    JOHN WEIS; Fiscal Year: 1993
    ..participate in immune and inflammatory responses [including mast cells, basophils, natural killer cells, cytotoxic T lymphocytes, eosinophils, neutrophils, macrophages, and platelets] store a unique family of proteoglycans in an ..
  3. Define the role of dendritic cells in HTLV-1 associated neuroinflammatory disease
    Pooja Jain; Fiscal Year: 2009
    ..The progression of HAM/TSP is characterized by an intense proliferation of chronically activated CD8+ cytotoxic T lymphocytes (CTLs), 90% of which are specific for the HTLV-1 transactivator protein Tax...
  4. Define the role of dendritic cells in HTLV-1 associated neuroinflammatory disease
    Pooja Jain; Fiscal Year: 2010
    ..The progression of HAM/TSP is characterized by an intense proliferation of chronically activated CD8+ cytotoxic T lymphocytes (CTLs), 90% of which are specific for the HTLV-1 transactivator protein Tax...
  5. Define the role of dendritic cells in HTLV-1 associated neuroinflammatory disease
    Pooja Jain; Fiscal Year: 2011
    ..The progression of HAM/TSP is characterized by an intense proliferation of chronically activated CD8+ cytotoxic T lymphocytes (CTLs), 90% of which are specific for the HTLV-1 transactivator protein Tax...
  6. TH1 CYTOKINES AND IMPAIRED CD8* CTLS IN ELDERLY
    Innocent Mbawuike; Fiscal Year: 2001
    ..the Applicant's Abstract): The objectives of this proposal are to determine the mechanisms of deficient cytotoxic T lymphocytes (CD8+ CTL) activity against influenza virus among elderly persons and how this deficiency can be ..
  7. PATHOGENESIS OF HEPATITIS B VIRUS IN TRANSGENIC MICE
    FRANCIS CHISARI; Fiscal Year: 2004
    ..We recently proved that viral hepatitis has an immunologocal basis by showing that HBV-specific cytotoxic T lymphocytes (CTLs) cause acute hepatitis when injected into HBV transgenic mice...
  8. Differentiation of Glioma from Radiation Injury Using Cellular MRI
    Syed Ali; Fiscal Year: 2007
    ..Genetically engineered CTL can also be used. This magnetic labeling technique will also help investigators to track the injected CTL in the body as well as in the targeted areas by magnetic resonance imaging (MRI). ..
  9. Engineered tumor-specific T cells Resist Hypoxic-Tumor Immunosuppressive Attacks.
    Patricia Yotnda; Fiscal Year: 2010
    ..Although adoptive transfer of cytotoxic T lymphocytes (CTLs) is a promising therapy for many cancers, they often fail to eliminate tumors or to provide long-..
  10. HIV-1 Specific Cytotoxic T Lymphocytes in Breastmilk
    Grace John Stewart; Fiscal Year: 2003
    ..Some uninfected infants born to HIV-1 infected women generate HIV-1 specific cytotoxic T lymphocytes (CTLs), suggesting viral antigenic exposure sufficient to induce immunity but not to establish infection...
  11. GRANZYMES AND CYTOTOXIC LYMPHOCYTE FUNCTIONS
    TIMOTHY LEY; Fiscal Year: 1999
    ..The severityof GVHD wll be analysed using histopathologic and immunohistochemical methods. The Applicant also plans to determine whether granzyme- deficient NK cells are capable of normal rejection of hematopoietic stem cells. ..
  12. Immunoregulation and immunotherapy of breast cancer
    Robert H Vonderheide; Fiscal Year: 2010
    ..We have shown that cytotoxic T lymphocytes recognize peptides derived from hTERT and survivin and kill tumors cells expressing these proteins across ..
  13. Using the MHC class I cytoplasmic tail to control tumor Ag presentation by DCs
    Gregory A Lizee; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Immunotherapies that utilize cytotoxic T lymphocytes (CTLs) have proven effective at eradicating large tumor burdens in both animal models and human cancer patients...
  14. Adoptive Transfer of AlloCTL for Immunotherapy of Recurrent Gliomas
    Linda M Liau; Fiscal Year: 2010
    ..have achieved both pre-clinical and clinical success with adoptive transfer of intracavitary alloreactive cytotoxic T lymphocytes (aCTL), which are sensitized to the tumor host's human leukocyte antigens (HLA)...
  15. CELL-MEDIATED IMMUNITY IN HEPATITIS C VIRUS INFECTION
    Bruce Walker; Fiscal Year: 2000
    ..b>Cytotoxic T lymphocytes (CTL) have been shown to be an important component of protective immunity in a number of viral infections...
  16. New Approaches to the Biology and Treatment of Myelodysplastic Syndromes (MDS)
    Elihu Estey; Fiscal Year: 2007
    ..Achievement of these goals will be facilitated by the 240 patients seen annually at M.D. Anderson and the frequency with which these patients return for follow-up. ..
  17. HTLV Deregulation of CD40(L) in Cancer&Neurodegeneration
    Edward Harhaj; Fiscal Year: 2007
    The cellular immune response mediated by cytotoxic T lymphocytes (CTLs) plays a critical role in the identification and clearance of human T cell lymphotropic virus type I (HTLV-I)-infected cells...
  18. PROCESSED ANTIGEN CHARACTERIZATION BY MASS SPECTROMETRY
    Donald Hunt; Fiscal Year: 2009
    ..should make it possible to extend adoptive Tcell therapy beyond melanoma to other cancers including acute myeloid leukemia, chronic lymphocytic leukemia, pancreatic-, colorectal-, and heptocellullar adenocarcinoma and renal cancer ..
  19. PROCESSED ANTIGEN CHARACTERIZATION BY MASS SPECTROMETRY
    Donald F Hunt; Fiscal Year: 2010
    ..should make it possible to extend adoptive Tcell therapy beyond melanoma to other cancers including acute myeloid leukemia, chronic lymphocytic leukemia, pancreatic-, colorectal-, and heptocellullar adenocarcinoma and renal cancer ..
  20. CHEMOKINES IN CTL FUNCTION AND TRAFFICKING IN HIV
    Andrew Luster; Fiscal Year: 2004
    b>Cytotoxic T lymphocytes (CTL) play a critical role in host defense against viral infections, including HIV-1. Chemokines play an important role in several aspects of CTL function as CTL both produce and respond to chemokines...
  21. Nanoengineered HIV-1 Vaccines Based on Tat
    RUSSELL MUMPER; Fiscal Year: 2004
    ..Tat is efficiently processed by major histocompatibility complex (MHC) class I for presentation to cytotoxic T lymphocytes (CTL)...
  22. Inhibition of CTL killing by HSV
    KEITH JEROME; Fiscal Year: 2005
    ..One mechanism by which the host attempts to induce apoptosis of infected cells is through the action of cytotoxic T lymphocytes (Cm)...
  23. SPOTTED FEVER RICKETTSIAL ANTIGENS
    David H Walker; Fiscal Year: 2010
    ..Excellent animal models and the available human data reveal the critical importance of IFN-gamma, CD8 cytotoxic T lymphocytes, dendritic cells (DCs) and NK cells in host protective immunity against Rickettsia...
  24. ANTIGENIC DETERMINANTS ON HLA-B7 AND -A2
    VICTOR ENGELHARD; Fiscal Year: 1993
    ..to be the nature of the antigenic determinants on human MHC class molecules that are recognized by cytotoxic T lymphocytes (CTL)...
  25. MACROPHAGE ANTIGEN PROCESSING OF HIV SUBTYPES
    Kenneth Knox; Fiscal Year: 2005
    Adapted from applicant?s abstract) CD8+, MHC-1 restricted cytotoxic T lymphocytes (CTL) are responsible for controlling viremia associated with human immunodeficiency virus (HIV) infection...