cytotoxic t lymphocytes

Summary

Summary: Immunized T-lymphocytes which can directly destroy appropriate target cells. These cytotoxic lymphocytes may be generated in vitro in mixed lymphocyte cultures (MLC), in vivo during a graft-versus-host (GVH) reaction, or after immunization with an allograft, tumor cell or virally transformed or chemically modified target cell. The lytic phenomenon is sometimes referred to as cell-mediated lympholysis (CML). These CD8-positive cells are distinct from natural killer cells (KILLER CELLS, NATURAL) and from KILLER CELLS mediating antibody-dependent cell cytotoxicity. There are two effector phenotypes: TC1 and TC2.

Top Publications

  1. ncbi A gene encoding an antigen recognized by cytolytic T lymphocytes on a human melanoma
    P van der Bruggen
    Ludwig Institute for Cancer Research, Brussels, Belgium
    Science 254:1643-7. 1991
  2. ncbi Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen
    H Pircher
    Department of Experimental Pathology, University Hospital, Zurich, Switzerland
    Nature 342:559-61. 1989
  3. ncbi Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion
    Haidong Dong
    Department of Immunology, Mayo Clinic, Rochester, Minnesota, USA
    Nat Med 8:793-800. 2002
  4. pmc Fitness cost of escape mutations in p24 Gag in association with control of human immunodeficiency virus type 1
    Javier Martinez-Picado
    IrsiCaixa Foundation, University Hospital Germans Trias i Pujol, Barcelona, Spain
    J Virol 80:3617-23. 2006
  5. ncbi The immunological synapse of CTL contains a secretory domain and membrane bridges
    J C Stinchcombe
    Sir William Dunn School of Pathology, South Parks Road, Oxford, OX1 3RE, United Kingdom
    Immunity 15:751-61. 2001
  6. ncbi Help for cytotoxic-T-cell responses is mediated by CD40 signalling
    S R Bennett
    Immunology Division, The Walter and Eliza Hall Institute of Medical Research, PO The Royal Melbourne Hospital, Victoria, Australia
    Nature 393:478-80. 1998
  7. ncbi Influence of HLA-B57 on clinical presentation and viral control during acute HIV-1 infection
    Marcus Altfeld
    Partners AIDS Research Center and Infectious Disease Division, Massachusetts General Hospital, Boston, Massachusetts, USA
    AIDS 17:2581-91. 2003
  8. ncbi Evidence of HIV-1 adaptation to HLA-restricted immune responses at a population level
    Corey B Moore
    Centre for Clinical Immunology and Biomedical Statistics, Royal Perth Hospital and Murdoch University, Level 2 North Block, Royal Perth Hospital, Wellington Street, WA 6000, Australia
    Science 296:1439-43. 2002
  9. ncbi Regulatory T cells reversibly suppress cytotoxic T cell function independent of effector differentiation
    Thorsten R Mempel
    CBR Institute for Biomedical Research and Department of Pathology, Harvard Medical School, 200 Longwood Avenue, Boston, Massachusetts 02115, USA
    Immunity 25:129-41. 2006
  10. pmc Cytotoxic T lymphocytes established by seasonal human influenza cross-react against 2009 pandemic H1N1 influenza virus
    Wenwei Tu
    Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Room L7 58, 7 F Laboratory Block, Faculty of Medicine Building, 21 Sassoon Road, Hong Kong
    J Virol 84:6527-35. 2010

Detail Information

Publications377 found, 100 shown here

  1. ncbi A gene encoding an antigen recognized by cytolytic T lymphocytes on a human melanoma
    P van der Bruggen
    Ludwig Institute for Cancer Research, Brussels, Belgium
    Science 254:1643-7. 1991
    ..Thus, precisely targeted immunotherapy directed against antigen MZ2-E could be provided to individuals identified by HLA typing and analysis of the RNA of a small tumor sample...
  2. ncbi Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen
    H Pircher
    Department of Experimental Pathology, University Hospital, Zurich, Switzerland
    Nature 342:559-61. 1989
    ..Thus the same transgenic TCR-expressing T cells may be tolerized at different stages of their maturation and at different locations in the thymus depending on the antigen involved...
  3. ncbi Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion
    Haidong Dong
    Department of Immunology, Mayo Clinic, Rochester, Minnesota, USA
    Nat Med 8:793-800. 2002
    ..These findings have implications for the design of T cell-based cancer immunotherapy...
  4. pmc Fitness cost of escape mutations in p24 Gag in association with control of human immunodeficiency virus type 1
    Javier Martinez-Picado
    IrsiCaixa Foundation, University Hospital Germans Trias i Pujol, Barcelona, Spain
    J Virol 80:3617-23. 2006
    ....
  5. ncbi The immunological synapse of CTL contains a secretory domain and membrane bridges
    J C Stinchcombe
    Sir William Dunn School of Pathology, South Parks Road, Oxford, OX1 3RE, United Kingdom
    Immunity 15:751-61. 2001
    b>Cytotoxic T lymphocytes (CTL) rapidly destroy their targets...
  6. ncbi Help for cytotoxic-T-cell responses is mediated by CD40 signalling
    S R Bennett
    Immunology Division, The Walter and Eliza Hall Institute of Medical Research, PO The Royal Melbourne Hospital, Victoria, Australia
    Nature 393:478-80. 1998
    b>Cytotoxic T lymphocytes (CTLs) which carry the CD8 antigen recognize antigens that are presented on target cells by the class I major histocompatibility complex...
  7. ncbi Influence of HLA-B57 on clinical presentation and viral control during acute HIV-1 infection
    Marcus Altfeld
    Partners AIDS Research Center and Infectious Disease Division, Massachusetts General Hospital, Boston, Massachusetts, USA
    AIDS 17:2581-91. 2003
    ..However, their impact on viral replication during acute HIV-1 infection is not known...
  8. ncbi Evidence of HIV-1 adaptation to HLA-restricted immune responses at a population level
    Corey B Moore
    Centre for Clinical Immunology and Biomedical Statistics, Royal Perth Hospital and Murdoch University, Level 2 North Block, Royal Perth Hospital, Wellington Street, WA 6000, Australia
    Science 296:1439-43. 2002
    ..At a population level, the degree of HLA-associated selection in viral sequence was predictive of viral load. These results support a fundamental role for HLA-restricted immune responses in driving and shaping HIV-1 evolution in vivo...
  9. ncbi Regulatory T cells reversibly suppress cytotoxic T cell function independent of effector differentiation
    Thorsten R Mempel
    CBR Institute for Biomedical Research and Department of Pathology, Harvard Medical School, 200 Longwood Avenue, Boston, Massachusetts 02115, USA
    Immunity 25:129-41. 2006
    ..using multiphoton intravital microscopy in lymph nodes (LNs) of anesthetized mice, we have analyzed how cytotoxic T lymphocytes (CTLs) interact with antigen-presenting target cells in the presence or absence of activated T(reg) cells...
  10. pmc Cytotoxic T lymphocytes established by seasonal human influenza cross-react against 2009 pandemic H1N1 influenza virus
    Wenwei Tu
    Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Room L7 58, 7 F Laboratory Block, Faculty of Medicine Building, 21 Sassoon Road, Hong Kong
    J Virol 84:6527-35. 2010
    ..In this study, we demonstrate that the bulk memory cytotoxic T lymphocytes (CTLs) established by seasonal influenza viruses from healthy individuals who have not been exposed to ..
  11. ncbi Functional significance of the perforin/granzyme cell death pathway
    Joseph A Trapani
    Cancer Immunology Laboratory, Trescowthick Research Laboratories, Research Division, Peter MacCallum Cancer Institute, Locked Bag 1, A Beckett Street, Melbourne 8006, Australia
    Nat Rev Immunol 2:735-47. 2002
    ....
  12. ncbi Mesenchymal stem cells inhibit the formation of cytotoxic T lymphocytes, but not activated cytotoxic T lymphocytes or natural killer cells
    Ida Rasmusson
    Department of Clinical Immunology, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden
    Transplantation 76:1208-13. 2003
    ..There are no publications on the effect that MSCs have on cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells, effector cells vital for the graft-versus-leukemia effect.
  13. pmc Natural selection of tumor variants in the generation of "tumor escape" phenotypes
    Hung T Khong
    National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Nat Immunol 3:999-1005. 2002
    ..Tumor escape variants are likely to emerge after treatment with increasingly effective immunotherapies...
  14. ncbi Sublethal irradiation of human tumor cells modulates phenotype resulting in enhanced killing by cytotoxic T lymphocytes
    Charlie T Garnett
    Laboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892 1750, USA
    Cancer Res 64:7985-94. 2004
    ....
  15. ncbi Evolutionary and immunological implications of contemporary HIV-1 variation
    B Korber
    Division of Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, New Mexico 98545, USA
    Br Med Bull 58:19-42. 2001
    ..The impact of HIV-1 variation on host immune response is reviewed in this context...
  16. ncbi Epidermal viral immunity induced by CD8alpha+ dendritic cells but not by Langerhans cells
    Rhys S Allan
    Department of Microbiology and Immunology, The University of Melbourne, Melbourne, Victoria 3010, Australia
    Science 301:1925-8. 2003
    ..infection of murine epidermis by herpes simplex virus did not result in the priming of virus-specific cytotoxic T lymphocytes by Langerhans cells. Rather, the priming response required a distinct CD8alpha+ dendritic cell subset...
  17. ncbi A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell
    J P Ridge
    Ghost Lab, Section on T cell Tolerance and Memory, Laboratory of Cellular and Molecular Immunology, NIAID NIH, Bethesda, Maryland 20892, USA
    Nature 393:474-8. 1998
    ....
  18. pmc Antiviral defense in mice lacking both alpha/beta and gamma interferon receptors
    M F van den Broek
    Institute of Experimental Immunology, University of Zurich, Switzerland
    J Virol 69:4792-6. 1995
    ..Even though global antiviral immunoglobulin G (IgG) titers were within normal ranges, the IgG subclass distribution was heavily biased toward IgG1...
  19. ncbi Cellular immune responses to HIV
    A J McMichael
    MRC Human Immunology Unit, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DS, UK
    Nature 410:980-7. 2001
    ..The failure of the latter to function efficiently facilitates the escape of virus from immune control and the collapse of the whole immune system...
  20. ncbi Role of CD4+ cytotoxic T lymphocytes in the control of viral diseases and cancer
    Debora Martorelli
    Cancer Bioimmunotherapy Unit, Centro di Riferimento Oncologico, IRCCS National Cancer Institute, Aviano PN, Italy
    Int Rev Immunol 29:371-402. 2010
    ..This review summarizes available data supporting the functional and therapeutic relevance of cytotoxic CD4(+) T cells, with a particular focus on Epstein-Barr virus (EBV)-related disorders...
  21. ncbi Identification of HLA-A2- or HLA-A24-restricted CTL epitopes possibly useful for glypican-3-specific immunotherapy of hepatocellular carcinoma
    Hiroyuki Komori
    Department of Immunogenetics, Graduate School of Medical Sciences, Kumamoto University, Honjo, Japan
    Clin Cancer Res 12:2689-97. 2006
    ..In addition, we used HLA-A2.1 (HHD) transgenic mice to identify the HLA-A2 (A*0201)-restricted GPC3 epitopes to expand the applications of GPC3-based immunotherapy to the HLA-A2+ HCC patients...
  22. pmc Clustered mutations in HIV-1 gag are consistently required for escape from HLA-B27-restricted cytotoxic T lymphocyte responses
    A D Kelleher
    Medical Research Council Human Immunology Unit, Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS, United Kingdom
    J Exp Med 193:375-86. 2001
    ..Outgrowth of CTL escape viruses required high viral loads and additional, possibly compensatory, mutations in the gag protein...
  23. pmc Relative dominance of Gag p24-specific cytotoxic T lymphocytes is associated with human immunodeficiency virus control
    Rosario Zuniga
    Asociacion Civil Impacta Salud y Educacion, Lima, Peru
    J Virol 80:3122-5. 2006
    ..Analyses in a second cohort in the United States confirm these findings and point towards a dominant role of Gag-specific immunity in effective control of HIV infection, providing important guidance for HIV vaccine development...
  24. ncbi Vaccination with tumor lysate-pulsed dendritic cells elicits antigen-specific, cytotoxic T-cells in patients with malignant glioma
    John S Yu
    Maxine Dunitz Neurosurgical Institute, Cedars Sinai Medical Center, 8631 West Third Street, Suite 800E, Los Angeles, CA 90048, USA
    Cancer Res 64:4973-9. 2004
    ..We demonstrate for the first time the ability of an active immunotherapy strategy to generate antigen-specific cytotoxicity in brain tumor patients...
  25. ncbi A prospective study demonstrates an association between JC virus-specific cytotoxic T lymphocytes and the early control of progressive multifocal leukoencephalopathy
    Renaud A Du Pasquier
    Division of ViralPathogenesis Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Brain 127:1970-8. 2004
    ..In previous studies, we showed that JCV-specific cytotoxic T lymphocytes (JCV-specific CTL) were associated with a favourable outcome in patients with PML...
  26. ncbi Idiotype-specific cytotoxic T lymphocytes in multiple myeloma: evidence for their capacity to lyse autologous primary tumor cells
    Y J Wen
    Myeloma and Transplantation Research Center, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Blood 97:1750-5. 2001
    ..Taken together, these findings represent the first demonstration that Id-specific CTLs are able to lyse autologous tumor cells in MM and, thus, provide a rationale for Id-based immunotherapy in the disease...
  27. pmc JC virus-specific cytotoxic T lymphocytes in individuals with progressive multifocal leukoencephalopathy
    I J Koralnik
    Department of Neurology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Virol 75:3483-7. 2001
    ..These cells were therefore cytotoxic T lymphocytes (CTL)...
  28. ncbi Analysis of a successful immune response against hepatitis C virus
    S Cooper
    Department of Structural Biology, Stanford University School of Medicine, California 94305 5400, USA
    Immunity 10:439-49. 1999
    ..Every specificity shown during acute hepatitis persisted in normal liver tissue more than 1 yr after resolution. These results suggest that CD8+CTL are better correlated with protection against HCV infection than antibodies...
  29. ncbi Cross-presentation: underlying mechanisms and role in immune surveillance
    Kenneth L Rock
    Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Immunol Rev 207:166-83. 2005
    ..In addition to the critical role of cross-presentation in normal immune physiology, this pathway has considerable potential for being exploited for developing subunit vaccines that elicit both CD4(+) and CD8(+) T-cell immunity...
  30. ncbi Cytotoxic T lymphocytes in autoimmune and degenerative CNS diseases
    Harald Neumann
    Neuroimmunology Unit, European Neuroscience Institute Göttingen, Waldweg 33, 37073 Gottingen, Germany
    Trends Neurosci 25:313-9. 2002
    b>Cytotoxic T lymphocytes (CTLs) with a CD8(+) phenotype have the potential to recognize and attack major histocompatibility complex (MHC) class I-expressing brain cells...
  31. ncbi Cross-presentation by intercellular peptide transfer through gap junctions
    Joost Neijssen
    Division of Tumor Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Nature 434:83-8. 2005
    ....
  32. ncbi CD4+ T cells are required for secondary expansion and memory in CD8+ T lymphocytes
    Edith M Janssen
    Division of Cellular Immunology and Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, California 92121, USA
    Nature 421:852-6. 2003
    ..Our results demonstrate that T-cell help is 'programmed' into CD8+ T cells during priming, conferring on these cells a hallmark of immune response memory: the capacity for functional expansion on re-encounter with antigen...
  33. ncbi T cell receptor recognition of a 'super-bulged' major histocompatibility complex class I-bound peptide
    Fleur E Tynan
    The Protein Crystallography Unit, Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Clayton, Victoria 3800, Australia
    Nat Immunol 6:1114-22. 2005
    ..Thus our findings simultaneously demonstrate the considerable adaptability of the TCR and the 'shape' of MHC restriction...
  34. ncbi DNAM-1, a novel adhesion molecule involved in the cytolytic function of T lymphocytes
    A Shibuya
    DNAX Research Institute of Molecular and Cellular Biology, Department of Human Immunology, Palo Alto, California 94304 1104, USA
    Immunity 4:573-81. 1996
    ..In addition, DNAM-1 is a tyrosine-phosphorylated signal-transducing molecule that participates in primary adhesion during cytotoxic T lymphocyte (CTL)-mediated cytotoxicity...
  35. ncbi Melanoma cell expression of Fas(Apo-1/CD95) ligand: implications for tumor immune escape
    M Hahne
    Institute of Biochemistry, University of Lausanne, CH 1066 Epalinges, Switzerland
    Science 274:1363-6. 1996
    ..In contrast, tumorigenesis was delayed in Fas-deficient lpr mutant mice in which immune effector cells cannot be killed by FasL. Thus, FasL may contribute to the immune privilege of tumors...
  36. ncbi Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells
    Susanne J Szabo
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    Science 295:338-42. 2002
    ..This difference is also apparent in the function of these cell subsets. Thus, the regulation of a single cytokine, IFN-gamma, is controlled by distinct transcriptional mechanisms within the T cell lineage...
  37. ncbi Reversible HLA multimers (Streptamers) for the isolation of human cytotoxic T lymphocytes functionally active against tumor- and virus-derived antigens
    Julia Neudorfer
    Department of Hematology Oncology, Klinikum rechts der Isar, Technical University of Munich, Germany
    J Immunol Methods 320:119-31. 2007
    ....
  38. ncbi Perforin gene defects in familial hemophagocytic lymphohistiocytosis
    S E Stepp
    Department of Pathology and the Graduate Program in Immunology, University of Texas Southwestern Medical School, Dallas, TX 75235, USA
    Science 286:1957-9. 1999
    ..Thus, defects in perforin are responsible for 10q21-22-linked FHL. Perforin-based effector systems are, therefore, involved not only in the lysis of abnormal cells but also in the down-regulation of cellular immune activation...
  39. pmc Structural and functional constraints limit options for cytotoxic T-lymphocyte escape in the immunodominant HLA-B27-restricted epitope in human immunodeficiency virus type 1 capsid
    Arne Schneidewind
    Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Virol 82:5594-605. 2008
    ....
  40. ncbi Cell therapy of stage IV nasopharyngeal carcinoma with autologous Epstein-Barr virus-targeted cytotoxic T lymphocytes
    Patrizia Comoli
    Laboratorio di Ricerca Area Trapianti e Oncoematologia Pediatrica, IRCCS Policlinico S Matteo, V le Golgi 19, 27100 Pavia, Italy
    J Clin Oncol 23:8942-9. 2005
    ..We conducted a clinical trial of EBV-targeted cell therapy with autologous virus-specific cytotoxic T lymphocytes (CTLs) for NPC refractory to conventional treatments.
  41. ncbi B7-H3: a costimulatory molecule for T cell activation and IFN-gamma production
    A I Chapoval
    Department of Immunology, Mayo Graduate and Medical Schools, Mayo Clinic, Rochester, MN 55905, USA
    Nat Immunol 2:269-74. 2001
    ..Thus, we describe a newly identified costimulatory pathway that may participate in the regulation of cell-mediated immune responses...
  42. ncbi T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions
    S P Schoenberger
    Department of Immunohematology and Blood Bank, University Hospital Leiden, The Netherlands
    Nature 393:480-3. 1998
    Although in vivo priming of CD8+ cytotoxic T lymphocytes (CTLs) generally requires the participation of CD4+ T-helper lymphocytes, the nature of the 'help' provided to CTLs is unknown...
  43. ncbi HIV evolution: CTL escape mutation and reversion after transmission
    A J Leslie
    Department of Pediatrics, Fuffield Department of Medicine, Peter Medawar Building for Pathogen Research, University of Oxford, Oxford OX1 3SY, UK
    Nat Med 10:282-9. 2004
    ..Complex epitope- and residue-specific selection forces, including CTL-mediated positive selection pressure and virus-mediated purifying selection, operate in tandem to shape HIV evolution at the population level...
  44. ncbi In vivo high resolution three-dimensional imaging of antigen-specific cytotoxic T-lymphocyte trafficking to tumors
    Moritz F Kircher
    Center for Molecular Imaging Research, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Cancer Res 63:6838-46. 2003
    ..CD8+ cytotoxic T lymphocytes labeled with CLIO-HD were detectable via MRI with a detection threshold of 2 cells/voxel in vitro and ..
  45. ncbi HIV-1 viral escape in infancy followed by emergence of a variant-specific CTL response
    Margaret E Feeney
    Partners AIDS Research Center and Infectious Disease Division, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Immunol 174:7524-30. 2005
    ..Taken together, these findings indicate that the developing immune system of children may exhibit greater plasticity in responding to a continually evolving chronic viral infection...
  46. ncbi Differential T cell costimulatory requirements in CD28-deficient mice
    A Shahinian
    Department of Medical Biophysics and Immunology, University of Toronto, Canada
    Science 261:609-12. 1993
    ..Thus, CD28 is not required for all T cell responses in vivo, suggesting that alternative costimulatory pathways may exist...
  47. ncbi Mutations in RAB27A cause Griscelli syndrome associated with haemophagocytic syndrome
    G Menasche
    1 Unité de Recherches sur le Dévelopment Normal et Pathologique du Système Immunitaire INSERM U429, Paris, France
    Nat Genet 25:173-6. 2000
    ..RAB27A appears to be a key effector of cytotoxic granule exocytosis, a pathway essential for immune homeostasis...
  48. ncbi The Fas death factor
    S Nagata
    Osaka Bioscience Institute, Japan
    Science 267:1449-56. 1995
    ..Malfunction of the Fas system causes lymphoproliferative disorders and accelerates autoimmune diseases, whereas its exacerbation may cause tissue destruction...
  49. ncbi Conflicting selective forces affect T cell receptor contacts in an immunodominant human immunodeficiency virus epitope
    Astrid K N Iversen
    Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9AD, UK
    Nat Immunol 7:179-89. 2006
    b>Cytotoxic T lymphocytes (CTLs) are critical for the control of human immunodeficiency virus, but containment of virus replication can be undermined by mutations in CTL epitopes that lead to virus escape...
  50. ncbi Prospects for an influenza vaccine that induces cross-protective cytotoxic T lymphocytes
    Lorena E Brown
    Department of Microbiology and Immunology, The University of Melbourne, Parkville, Victoria, Australia
    Immunol Cell Biol 87:300-8. 2009
    ..and those with the potential to cause a pandemic share amino acid sequences that form the targets of cytotoxic T lymphocytes (CTL)...
  51. ncbi Phase I study of adoptive T-cell therapy using antigen-specific CD8+ T cells for the treatment of patients with metastatic melanoma
    Andreas Mackensen
    Department of Hematology Oncology, University of Regensburg, Franz Josef Strauss Allee 11, D 93042 Regensburg, Germany
    J Clin Oncol 24:5060-9. 2006
    The adoptive transfer of in vitro generated tumor antigen-specific cytotoxic T lymphocytes (CTL) provides a promising approach to the immunotherapy of cancer...
  52. ncbi The vascular disrupting agent, DMXAA, directly activates dendritic cells through a MyD88-independent mechanism and generates antitumor cytotoxic T lymphocytes
    Africa Wallace
    Thoracic Oncology Research Laboratory, Department of Medicine, University of Pennsylvania School of Medicine, 421 Curie Boulevard, Philadelphia, PA 19104, USA
    Cancer Res 67:7011-9. 2007
    ..DMXAA thus has the ability to activate tumor-specific CD8(+) T cells through multiple pathways that include induction of tumor cell death, release of stimulatory cytokines, and direct activation of dendritic cells...
  53. ncbi A structural basis for the selection of dominant alphabeta T cell receptors in antiviral immunity
    Lars Kjer-Nielsen
    Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria 3010, Australia
    Immunity 18:53-64. 2003
    ..These findings indicate that TCR immunodominance is associated with structural properties conferring receptor specificity and suggest a novel structural link between TCR ligation and intracellular signaling...
  54. pmc The immunogenicity of a viral cytotoxic T cell epitope is controlled by its MHC-bound conformation
    Fleur E Tynan
    The Protein Crystallography Unit, Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Clayton, Victoria, Australia
    J Exp Med 202:1249-60. 2005
    ..It also illustrates a novel mechanism through which MHC polymorphism can further diversify the immune response to infecting pathogens...
  55. ncbi Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice
    D Kagi
    Department of Pathology, University of Zurich, Switzerland
    Nature 369:31-7. 1994
    ..The mice fail to clear lymphocytic choriomeningitis virus and they eliminate fibrosarcoma tumour cells with reduced efficiency. Perforin is therefore a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis...
  56. ncbi The HLA A*0201-restricted hTERT(540-548) peptide is not detected on tumor cells by a CTL clone or a high-affinity T-cell receptor
    Marco A Purbhoo
    Avidex Ltd, 57 59 Milton Park, Abingdon, OX14 4RX, United Kingdom
    Mol Cancer Ther 6:2081-91. 2007
    ..We propose that, in future, rigorous methods must be applied for the validation of peptide epitopes used for clinical applications...
  57. pmc Cellular immune responses and viral diversity in individuals treated during acute and early HIV-1 infection
    M Altfeld
    Partners AIDS Research Center and Infectious Disease Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02129, USA
    J Exp Med 193:169-80. 2001
    ..Using HIV as a model, we examined virus-specific cytotoxic T lymphocytes (CTLs), T helper cells, and viral genetic diversity in relation to duration of infection and subsequent ..
  58. ncbi Centrosome polarization delivers secretory granules to the immunological synapse
    Jane C Stinchcombe
    Sir William Dunn School of Pathology, South Parks Road, Oxford OX1 3RE, UK
    Nature 443:462-5. 2006
    b>Cytotoxic T lymphocytes (CTLs) destroy virally infected and tumorigenic cells by releasing the contents of specialized secretory lysosomes--termed 'lytic granules'--at the immunological synapse formed between the CTL and the target...
  59. pmc The human cytotoxic T-lymphocyte (CTL) response to cytomegalovirus is dominated by structural protein pp65: frequency, specificity, and T-cell receptor usage of pp65-specific CTL
    M R Wills
    Department of Medicine, University of Cambridge Clinical School, United Kingdom
    J Virol 70:7569-79. 1996
    b>Cytotoxic T lymphocytes (CTL) appear to play an important role in the control of human cytomegalovirus (HCMV) in the normal virus carrier: previous studies have identified peripheral blood CD8+ CTL specific for the HCMV major immediate-..
  60. pmc Escape from the dominant HLA-B27-restricted cytotoxic T-lymphocyte response in Gag is associated with a dramatic reduction in human immunodeficiency virus type 1 replication
    Arne Schneidewind
    Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    J Virol 81:12382-93. 2007
    ....
  61. ncbi Cross-reactive cytotoxic T lymphocytes against a HIV-1 p24 epitope in slow progressors with B*57
    Geraldine M A Gillespie
    MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, OX3 9DS, UK
    AIDS 16:961-72. 2002
    ....
  62. ncbi Recognition of ADP-ribosylation factor 4-like by HLA-A2-restricted and tumor-reactive cytotoxic T lymphocytes from patients with brain tumors
    Y Nonaka
    Department of Immunology, Kurume University School of Medicine, Fukuoka, Japan
    Tissue Antigens 60:319-27. 2002
    ..In this study, we tried to identify brain tumor antigens using HLA-A2-restricted and tumor-reactive cytotoxic T lymphocytes (CTLs)...
  63. pmc Intrinsic functional dysregulation of CD4 T cells occurs rapidly following persistent viral infection
    David G Brooks
    Division of Virology, Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Virol 79:10514-27. 2005
    ....
  64. pmc In vivo T lymphocyte dynamics in humans and the impact of human T-lymphotropic virus 1 infection
    Becca Asquith
    Department of Immunology, Imperial College, London W2 1PG, United Kingdom
    Proc Natl Acad Sci U S A 104:8035-40. 2007
    ..We suggest that there is persistent viral gene expression in vivo, which is necessary for the maintenance of the proviral load and determines HTLV-1-associated myelopathy/tropical spastic paraparesis risk...
  65. pmc Adeno-associated virus type 2 (AAV2) capsid-specific cytotoxic T lymphocytes eliminate only vector-transduced cells coexpressing the AAV2 capsid in vivo
    Chengwen Li
    Gene Therapy Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Virol 81:7540-7. 2007
    ..In addition, our data suggest that the mouse model may not mimic the immune response noted in humans and additional modification to AAV vectors may be required for further study in order to elicit a similar cellular immune response...
  66. ncbi Increased permeability of human endothelial cell line EA.hy926 induced by hantavirus-specific cytotoxic T lymphocytes
    Daisuke Hayasaka
    Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Virus Res 123:120-7. 2007
    ..Some evidence suggests that hantavirus disease pathogenesis is immunologically mediated by cytotoxic T lymphocytes and other immune cells in target organs producing inflammatory cytokines...
  67. ncbi Recognition of HLA-A2-restricted mammaglobin-A-derived epitopes by CD8+ cytotoxic T lymphocytes from breast cancer patients
    André Jaramillo
    Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    Breast Cancer Res Treat 88:29-41. 2004
    ..purpose of this study was to identify HLA-A2-restricted mammaglobin-A-derived epitopes recognized by CD8+ cytotoxic T lymphocytes (CTL). We identified seven mammaglobin-A-derived candidate epitopes that bind the HLA-A2 molecule (Mam-A2...
  68. ncbi Circulating donor-specific cytotoxic T lymphocytes with high avidity for donor human leukocyte antigens in pediatric and adult cardiac allograft valved conduit recipients
    F B Oei
    Departments of Thoracic Surgery, Internal Medicine I and Heart Valve Bank Rotterdam, Room BD158, University Hospital Rotterdam, P O Box 2040, 3000 CA, The, Rotterdam, Netherlands
    Eur J Cardiothorac Surg 18:466-72. 2000
    ..Rejection of heart and corneal allografts is preceded by an increase in the fraction of cytotoxic T lymphocytes (CTL) with high avidity for donor human leukocyte antigens (HLA) circulating in both peripheral blood and ..
  69. ncbi HLA-A*26, HLA-B*4002, HLA-B*4006, and HLA-B*4801 alleles predispose to adult T cell leukemia: the limited recognition of HTLV type 1 tax peptide anchor motifs and epitopes to generate anti-HTLV type 1 tax CD8(+) cytotoxic T lymphocytes
    S Yashiki
    Department of Virology, Faculty of Medicine, Kagoshima University, Kagoshima 890 8520, Japan
    AIDS Res Hum Retroviruses 17:1047-61. 2001
    ..anchor motifs of HTLV-1 peptides binding to HLA class I molecules, using 291 lines of anti-HTLV-1 CD8(+) cytotoxic T lymphocytes (CTLs) generated in vitro with a total of 165 synthetic peptides for HTLV-1 Tax and Env proteins...
  70. ncbi Cytotoxic lymphocytes; instigators of dramatic target cell death
    Nigel J Waterhouse
    Peter MacCallum Cancer Centre, Locked Bag 1, A Beckett St, Melbourne, VIC 8006, Australia
    Biochem Pharmacol 68:1033-40. 2004
    ....
  71. ncbi Adenovirus-based vaccines generate cytotoxic T lymphocytes to epitopes of NS1 from dengue virus that are present in all major serotypes
    Guangping Gao
    Vaccine Research Institute, Sun Yat Sen University, Guangzhou, 510630, China
    Hum Gene Ther 19:927-36. 2008
    ....
  72. pmc Generation of Epstein-Barr virus-specific cytotoxic T lymphocytes resistant to the immunosuppressive drug tacrolimus (FK506)
    Biagio De Angelis
    Center for Cell and Gene Therapy, Baylor College of Medicine, The Methodist Hospital and Texas Children s Hospital, Houston, TX 77030, USA
    Blood 114:4784-91. 2009
    Adoptive transfer of autologous Epstein-Barr virus-specific cytotoxic T lymphocytes (EBV-CTLs) to solid organ transplant (SOT) recipients has been shown safe and effective for the treatment of EBV-associated posttransplantation ..
  73. ncbi Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells
    J W Heusel
    Department of Medicine, Jewish Hospital, St Louis, Missouri 63110
    Cell 76:977-87. 1994
    ..Gzm B-/- mice develop normally and have normal hematopoiesis and lymphopoiesis. In vitro, cytotoxic T lymphocytes (CTL) derived from gzm B-/- animals are able to induce 51Cr release from allotarget cells, but with ..
  74. pmc Cytotoxic T lymphocytes directed to the preferentially expressed antigen of melanoma (PRAME) target chronic myeloid leukemia
    Concetta Quintarelli
    Center for Cell and Gene Therapy, Baylor College of Medicine, The Methodist Hospital and Texas Children s Hospital, Houston, TX 77030, USA
    Blood 112:1876-85. 2008
    ..We therefore tested whether functional PRAME-specific cytotoxic T lymphocytes (PRAME CTLs) could be generated and expanded from healthy donors and CML patients, or whether the limited ..
  75. ncbi Secretory cytotoxic granule maturation and exocytosis require the effector protein hMunc13-4
    Mickaël M Ménager
    Institut National de la Santé et de la Recherche Médicale Unité 768, Laboratoire du Développement Normal et Pathologique du Système Immunitaire, Paris F 75015 France
    Nat Immunol 8:257-67. 2007
    b>Cytotoxic T lymphocytes and natural killer cells exert their cytotoxic activity through the polarized secretion of cytotoxic granules at the immunological synapse...
  76. ncbi Highly efficient gene delivery by mRNA electroporation in human hematopoietic cells: superiority to lipofection and passive pulsing of mRNA and to electroporation of plasmid cDNA for tumor antigen loading of dendritic cells
    V F Van Tendeloo
    Laboratory of Experimental Hematology, Antwerp University Hospital, University of Antwerp, Antwerp, Belgium
    Blood 98:49-56. 2001
    ..Therefore, electroporation of mRNA-encoding tumor antigens is a powerful technique to charge human dendritic cells with tumor antigens and could serve applications in future DC-based tumor vaccines...
  77. ncbi Ex vivo induction of multiple myeloma-specific cytotoxic T lymphocytes
    Toshiaki Hayashi
    Jerome Lipper Multiple Myeloma Center, Department of Medical Oncology, Dana Farber Cancer Institute, 44 Binney St, Boston, MA 02115, USA
    Blood 102:1435-42. 2003
    ..sera inhibiting autologous anti-MM immunity and developed an ex vivo strategy for inducing MM-specific cytotoxic T lymphocytes (CTLs)...
  78. ncbi Tumor lysate-specific cytotoxic T lymphocytes in multiple myeloma: promising effector cells for immunotherapy
    Yue Jin Wen
    Myeloma and Transplantation Research Center, University of Arkansas for Medical Science, Little Rock 72205, USA
    Blood 99:3280-5. 2002
    ..immunotherapy, the current study was undertaken to generate and examine the function of myeloma-specific cytotoxic T lymphocytes (CTLs) by using dendritic cells (DCs) pulsed with myeloma cell lysates as stimulating cells...
  79. ncbi Characterization of an antigen that is recognized on a melanoma showing partial HLA loss by CTL expressing an NK inhibitory receptor
    H Ikeda
    Cellular Genetics Unit, Universite Catholique de Louvain, Brussels, Belgium
    Immunity 6:199-208. 1997
    ....
  80. pmc Human papillomavirus type 16 (HPV-16) virus-like particle L1-specific CD8+ cytotoxic T lymphocytes (CTLs) are equally effective as E7-specific CD8+ CTLs in killing autologous HPV-16-positive tumor cells in cervical cancer patients: implications for L1 den
    Stefania Bellone
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut 06520 8063, USA
    J Virol 83:6779-89. 2009
    ..expressed strong cytolytic activity against autologous tumor cells and were as effective as E7-specific cytotoxic T lymphocytes in lysing naturally HPV-16-infected autologous tumor cells...
  81. ncbi Induction of HM1.24 peptide-specific cytotoxic T lymphocytes by using peripheral-blood stem-cell harvests in patients with multiple myeloma
    Ali Jalili
    Department of Medicine and Bioregulatory Sciences, Institute of Health Biosciences, University of Tokushima Graduate School, Japan
    Blood 106:3538-45. 2005
    ..The ability of these peptides to generate cytotoxic T lymphocytes (CTLs) was examined in 20 healthy donors and 6 patients with MM by a reverse immunologic approach...
  82. pmc HV-1-specific cytotoxic T lymphocytes and breast milk HIV-1 transmission
    Grace C John-Stewart
    Department of Paediatrics, University of Nairobi, Nairobi, Kenya
    J Infect Dis 199:889-98. 2009
    ....
  83. ncbi TGF-beta directly targets cytotoxic T cell functions during tumor evasion of immune surveillance
    Dori A Thomas
    Cancer Biology and Genetics Program and Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Cancer Cell 8:369-80. 2005
    ..We demonstrate that TGF-beta acts on cytotoxic T lymphocytes (CTLs) to specifically inhibit the expression of five cytolytic gene products-namely, perforin, granzyme ..
  84. ncbi Intratumoral balance of regulatory and cytotoxic T cells is associated with prognosis of hepatocellular carcinoma after resection
    Qiang Gao
    Liver Cancer Institute, Zhong Shan Hospital and Shanghai Medical School, Fudan University, Key Laboratory for Carcinogenesis and Cancer Invasion, the Chinese Ministry of Education, Shanghai, People s Republic of China
    J Clin Oncol 25:2586-93. 2007
    ..To investigate the prognostic value of tumor-infiltrating lymphocytes (TILs), especially regulatory T cells (Tregs), in hepatocellular carcinoma (HCC) patients after resection...
  85. ncbi The generation and characterization of LMP2-specific CTLs for use as adoptive transfer from patients with relapsed EBV-positive Hodgkin disease
    Catherine M Bollard
    Center for Cell and Gene Therapy, Baylor College of Medicine, The Methodist Hospital and Texas Children s Hospital, Houston, Texas 77030, USA
    J Immunother 27:317-27. 2004
    ..The authors aimed to generate cytotoxic T lymphocytes (CTLs) from patients with relapsed HD by specifically targeting LMP2A...
  86. ncbi Fas ligand expression by neoplastic T lymphocytes mediates elimination of CD8+ cytotoxic T lymphocytes in mycosis fungoides: a potential mechanism of tumor immune escape?
    X Ni
    Department of Dermatology, University of Texas, M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 7:2682-92. 2001
    ..01 +/- 0.86%) compared with non-FasL expressing areas (13.53 +/- 3.54%; P < 0.02). These results suggest that a potential mechanism of tumor immune escape in MF is FasL-mediated apoptosis of infiltrating CD8+ CTLs...
  87. pmc B7H costimulates clonal expansion of, and cognate destruction of tumor cells by, CD8(+) T lymphocytes in vivo
    X Liu
    Department of Pathology and Comprehensive Cancer Center, Ohio State University Medical Center, Columbus, OH 43210, USA
    J Exp Med 194:1339-48. 2001
    ..Taken together, our results reveal that B7H costimulates clonal expansion of, and cognate destruction by CD8(+) T lymphocytes in vivo...
  88. pmc Autologous dendritic cells transfected with prostate-specific antigen RNA stimulate CTL responses against metastatic prostate tumors
    Axel Heiser
    Cancer Immunotherapy Program, Division of Urology, Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Clin Invest 109:409-17. 2002
    ....
  89. pmc Biological and immunological properties of human immunodeficiency virus type 1 envelope glycoprotein: analysis of proteins with truncations and deletions expressed by recombinant vaccinia viruses
    P L Earl
    Laboratories of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892
    J Virol 65:31-41. 1991
    ..The predominant conserved B-cell epitopes were mapped to gp41 and the C terminus of gp120, whereas cytotoxic T-cell epitopes were distributed throughout the length of the glycoproteins...
  90. ncbi Differences that matter: major cytotoxic T cell-stimulating minor histocompatibility antigens
    S Malarkannan
    Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA
    Immunity 13:333-44. 2000
    ..B immune response. The immunodominance of these antigens can be explained by their differential transcription in the donor versus the host strains and their expression in professional donor antigen-presenting cells...
  91. pmc Amino acid similarity accounts for T cell cross-reactivity and for "holes" in the T cell repertoire
    Sune Frankild
    Center for Biological Sequence Analysis, Technical University of Denmark, Lyngby, Denmark
    PLoS ONE 3:e1831. 2008
    ..Several studies suggest that CTL clones can recognize highly diverse peptides, some sharing no obvious sequence identity. The emerging realization in the field is that T cell receptors (TcR) recognize multiple distinct ligands...
  92. ncbi Complement component C3 promotes T-cell priming and lung migration to control acute influenza virus infection
    Manfred Kopf
    Molecular Biomedicine, Department of Environmental Sciences, Swiss Federal Institute of Technology, Zurich, Switzerland
    Nat Med 8:373-8. 2002
    ..Consequently, T-helper cell-dependent IgG responses were reduced in C3-/- mice but remained intact in Cr2-/- mice. These results demonstrate that complement induces specific immunity by promoting T-cell responses...
  93. ncbi HLA-A2 and -A24-restricted glypican-3-derived peptide vaccine induces specific CTLs: preclinical study using mice
    Yutaka Motomura
    Cancer Immunotherapy Project, Investigative Treatment Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa 277 8577, Japan
    Int J Oncol 32:985-90. 2008
    ..The results of this study suggested that IFA is one of the indispensable adjuvants for peptide-based immunotherapy, and that the immunological effect of peptide vaccines depends on the dose of peptide injected...
  94. ncbi Detection of peptide-specific cytotoxic T-lymphocyte precursors used for specific immunotherapy of pancreatic cancer
    Nobuaki Suzuki
    Department of Immunology, Kurume University School of Medicine, Fukuoka, Japan
    Int J Cancer 98:45-50. 2002
    ..Positive peptide profiles varied among patients. These results may provide a scientific basis for a new kind of cancer immunotherapy, namely, a CTL precursor-oriented peptide vaccine, for pancreatic cancer patients...
  95. pmc Identification of a gag-encoded cytotoxic T-lymphocyte epitope from FBL-3 leukemia shared by Friend, Moloney, and Rauscher murine leukemia virus-induced tumors
    W Chen
    Division of Oncology, Department of Medicine, University of Washington, Seattle 98195, USA
    J Virol 70:7773-82. 1996
    ..Immunization of C57BL/6 mice with FBL-3 readily elicits CD8+ cytotoxic T lymphocytes (CTL) capable of lysing FBL-3 as well as syngeneic leukemias induced by Moloney and Rauscher MuLV...
  96. ncbi Direct link between mhc polymorphism, T cell avidity, and diversity in immune defense
    Ilhem Messaoudi
    Vaccine and Gene Therapy Institute and the Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006, USA
    Science 298:1797-800. 2002
    ..Thus, much of the beneficial effect of the mhc polymorphism in immune defense may be due to its critical influence on the properties of the selected CTL repertoire...
  97. ncbi The HLA-A,B "negative" mutant cell line C1R expresses a novel HLA-B35 allele, which also has a point mutation in the translation initiation codon
    J Zemmour
    Department of Cell Biology, Stanford University, CA 94305 5400
    J Immunol 148:1941-8. 1992
    ....
  98. ncbi Assessment of the extent of variation in influenza A virus cytotoxic T-lymphocyte epitopes by using virus-specific CD8+ T-cell clones
    E G M Berkhoff
    Department of Virology and Postgraduate School of Molecular Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    J Gen Virol 88:530-5. 2007
    ..6 % of all CTL clones. For some of these CTL clones, the minimal epitope and the residues responsible for abrogation of T-cell recognition were identified...
  99. ncbi Antibodies to vascular endothelial growth factor enhance the efficacy of cancer immunotherapy by improving endogenous dendritic cell function
    D I Gabrilovich
    Department of Medicine and The Vanderbilt Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 6838, USA
    Clin Cancer Res 5:2963-70. 1999
    ..This effect was associated with the induction of significant anti-p53 CTL responses only in this group of mice. These data suggest that inhibition of VEGF may be a valuable adjuvant in the immunotherapy of cancer...
  100. pmc Concerted action of the FasL/Fas and perforin/granzyme A and B pathways is mandatory for the development of early viral hepatitis but not for recovery from viral infection
    S Balkow
    Max Planck Institut fur Immunbiologie, 79108 Freiburg, Universitat Freiburg, 79104 Freiburg, Germany
    J Virol 75:8781-91. 2001
    b>Cytotoxic T lymphocytes (CTL) play a major role in the recovery from primary viral infections and the accompanying tissue injuries...
  101. ncbi Virus-specific CD8(+) T cells with type 1 or type 2 cytokine profile are related to different disease activity in chronic hepatitis C virus infection
    C Prezzi
    Fondazione Andrea Cesalpino, Dipartimento di Medicina Interna, , Rome, Italy
    Eur J Immunol 31:894-906. 2001
    ....

Research Grants78

  1. Personalized Clinical Diagnostics and Beyond: Integrated Ring Resonator Arrays
    Ryan Bailey; Fiscal Year: 2009
    ..This technology promises to broadly impact the landscape of the biomedical sciences, both meeting the clinical diagnostic challenges of today and pioneering the paradigm-shifting discoveries of tomorrow. ..
  2. Importance of antigen specific immunoglobulin responses in controlling SIV/SHIV i
    Bapi Pahar; Fiscal Year: 2010
    ..Several studies have shown that strong CD8+ cytotoxic T lymphocytes (CTL) responses may be elicited by infection or vaccine candidates, which may correlate with marginal ..
  3. Prevention of Acute Lung Injury by IL-6 activated STAT3
    Ana Moran; Fiscal Year: 2010
    ....
  4. Present Homologous and Heterologous Antigen with Hepatitis E Virus
    R Holland Cheng; Fiscal Year: 2012
    ....
  5. Define the role of dendritic cells in HTLV-1 associated neuroinflammatory disease
    Pooja Jain; Fiscal Year: 2013
    ..The progression of HAM/TSP is characterized by an intense proliferation of chronically activated CD8+ cytotoxic T lymphocytes (CTLs), 90% of which are specific for the HTLV-1 transactivator protein Tax...
  6. Adipose Stem Cell Therapy for Krabbe Disease
    Bruce Bunnell; Fiscal Year: 2009
    ..is complicated by graft versus host disease, a severe immunological disorder characterized by engrafted cytotoxic T lymphocytes destruction of host tissues including the skin epithelium, intestinal mucosa, and kidneys...
  7. Polymicrobial interactions in the lung.
    JENNIFER MELINDA BOMBERGER; Fiscal Year: 2010
    ..reveal, suppresses influenza A virus antigen presentation by class I MHC molecules and the ability of cytotoxic T lymphocytes (CTL) to clear viral infections...
  8. Regulation of HBV Replication by the Immune System
    Luca G Guidotti; Fiscal Year: 2012
    ..Specifically, cytotoxic T lymphocytes (CTLs) play a major part in the development of liver disease and the resolution of HBV infection...
  9. HCV in Alcoholics
    Jack R Wands; Fiscal Year: 2011
    ..These investigations open new avenues to enhance antiviral immune response in the setting of chronic ethanol consumption by improving DC function. ..
  10. Polymicrobial Interactions in the Lung
    JENNIFER MELINDA BOMBERGER; Fiscal Year: 2013
    ..reveal, suppresses influenza A virus antigen presentation by class I MHC molecules and the ability of cytotoxic T lymphocytes (CTL) to clear viral infections...
  11. Use of Allogenicity to Stimulate Effector Responses Against Multiple Myeloma
    Christina N Johnson; Fiscal Year: 2013
    ..in Multiple myeloma cells, has been shown to stimulate interferon gamma expression by myeloma-specific cytotoxic T lymphocytes (CTLs)7...
  12. Effects of Ethanol on Proteasome-HCV Core Protein Interactions
    NATALIA ALEKSANDR OSNA; Fiscal Year: 2010
    ..We envision that this research will potentially have therapeutic applications, helping to improve chronic hepatitis C treatment and vaccine development ..
  13. CYTOTOXIC RESPONSE TO HISTOCOMPATIBILITY ANTIGENS
    Michael J Bevan; Fiscal Year: 2012
    ..b>Cytotoxic T lymphocytes which express the CD8 marker, are of vital importance in the response to many intracellular infectious ..
  14. mt-Nd2 and Resistance to Autoimmune Diabetes
    Clayton E Mathews; Fiscal Year: 2013
    ..genetic background, the ALR-derived genetic variant does in fact protect beta cells from destruction by cytotoxic T lymphocytes as well as combined cytokines...
  15. Structural Immunology of CD1 and CD1-TCR Complexes
    Dirk M Zajonc; Fiscal Year: 2013
    ..antigens presented by CD1 molecules and can trigger killing of the antigen presenting cell, through cytotoxic T lymphocytes (CTLs), or recruit help (T helper cells) from the humoral immune system through production of soluble ..
  16. Genome-wide Identification of Minor Histocompatibility Antigens
    Shoudan Liang; Fiscal Year: 2012
    ..GVL is mediated by cytotoxic T lymphocytes (CTLs) that recognize the minor histocompatibility antigens (mHAs) derived from the genetic differences ..
  17. mt-Nd2 and Resistance to Autoimmune Diabetes
    Clayton E Mathews; Fiscal Year: 2011
    ..genetic background, the ALR-derived genetic variant does in fact protect beta cells from destruction by cytotoxic T lymphocytes as well as combined cytokines...
  18. PROCESSED ANTIGEN CHARACTERIZATION BY MASS SPECTROMETRY
    Donald F Hunt; Fiscal Year: 2012
    ..abstract_text> ..
  19. Engineered tumor-specific T cells Resist Hypoxic-Tumor Immunosuppressive Attacks.
    Patricia Yotnda; Fiscal Year: 2013
    ..Although adoptive transfer of cytotoxic T lymphocytes (CTLs) is a promising therapy for many cancers, they often fail to eliminate tumors or to provide long-..
  20. Granzyme a Pathway of CTL-Mediated Cell Death
    Judy Lieberman; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Cytotoxic T lymphocytes and natural killer cells release granzymes and perforin from cytotoxic granules into the immune synapse to induce apoptosis of virally infected or tumor targets...
  21. Synthetic Gypsogenin Saponins as Synergistic Vaccine Adjuvants
    ASHISH KUMAR PATHAK; Fiscal Year: 2013
    ..antigens to the cytosol of antigen-presenting cells to be processed for presentation to and activation of cytotoxic T lymphocytes (CTL)...
  22. A High-throughput Screen of Lytic Granule Exocytosis
    Adam Zweifach; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Target cell killing by cytotoxic T lymphocytes (CTLs) is critical for the immune response to viruses and tumors, is involved in transplant rejection and contributes to autoimmune disease pathogenesis...
  23. Develop an Oral HIV Vaccine Using Papilloma Virus-Like Particles as a Vector
    Liang Qiao; Fiscal Year: 2012
    ..to mucosal and systemic gp41 and gp120- specific neutralizing antibodies and Gag and Envelop-specific cytotoxic T lymphocytes. We will also develop oral commensal bacteria (S. gordonii and L...
  24. Transforming Growth Factor-Beta Signal Transduction
    Joan Massague; Fiscal Year: 2013
    ..Building on this progress, we will investigate the connectivity and regulation of TGF-beta and BMP pathways with other major regulators of cell behavior in the normal and the malignant state. ..
  25. Oxygen as a master immunologic switch
    Christopher A Pennell; Fiscal Year: 2013
    ..We have reproducibly shown that lysates from glioma cells cultured in 5% O2 prime cytotoxic T lymphocytes (CTLs) with superior effector functions relative to lysate from glioma cells cultured in 20% O2 in human ..
  26. Regulation of nucleosome positions and transcription during CTL differentiation
    MATTHEW EUGENE PIPKIN; Fiscal Year: 2013
    ..Summary Activation of naive CD8 T cells initiates their differentiation into effector and memory cytotoxic T lymphocytes (CTL) that control infections and tumors using the cytotoxic proteins perforin (Prf1), granzyme B (Gzmb), ..
  27. Paraptosis induction by BK channel activation to improve glioma cancer therapy
    Martin R Jadus; Fiscal Year: 2013
    ..BK channel found within gliomas, called the glioma BK channel (gBK), has 2 epitopes that can stimulate cytotoxic T lymphocytes (CTLs)...
  28. Anti-viral and antileukemic T-cell therapy as prophylaxis after HSCT
    Helen E Heslop; Fiscal Year: 2013
    ..Our center has developed a novel approach that effectively expands cytotoxic T lymphocytes (CTL) specific for cytomegalovirus, Epstein-Barr virus and adenoviruses from T- cells in a single culture...
  29. Immunoregulation and immunotherapy of breast cancer
    Robert H Vonderheide; Fiscal Year: 2012
    ..We have shown that cytotoxic T lymphocytes recognize peptides derived from hTERT and survivin and kill tumors cells expressing these proteins across ..
  30. Ewing's Sarcoma Resistance to Immunity and Radiation
    Joyce C Solheim; Fiscal Year: 2013
    ..the function of MHC class I molecules is to present antigens (including cancer-associated antigens) to cytotoxic T lymphocytes, reduction of their surface expression could cause immune evasion...
  31. Uncontrolled diabetes, immune dysregulation and tuberculosis
    Blanca I Restrepo; Fiscal Year: 2010
    ..protection or exacerbation of TB (adaptive response), and iii) expression of effectors by macrophages or cytotoxic T lymphocytes that ultimately kill MTB (effector response)...
  32. Novel Immunotherapy of Glioma using miR-17-92 Transfected T Cells
    Hideho Okada; Fiscal Year: 2013
    ..We therefore hypothesize that engineering TA-specific cytotoxic T lymphocytes (CTLs) to express the miR-17-92 cluster will provide potent and durable antitumor activity by ..
  33. Optimizing Induction Conditions for Immunotherapeutic CTL
    Boris Minev; Fiscal Year: 2013
    ..NP-PRR activated DC will then be used to stimulate alloreactive or autologous naive T cells to effector cytotoxic T lymphocytes (CTL) "NP-PRR stimulated DC and subsequently stimulated CTL will be functionally and phenotypically ..
  34. Enhancing T Cell Therapy of Cancer
    Cliona M Rooney; Fiscal Year: 2013
    ..Project 1 tests the use of VZV vaccination to boost the expansion and antitumor activity of VZV-specific cytotoxic T lymphocytes (CTLs) engrafted with a GD2-directed chimeric antigen receptor (CAR) in patients with relapsed/refractory ..
  35. Pseudomonas-Host Interactions in Cystic Fibrosis
    Bruce A Stanton; Fiscal Year: 2013
    ..with Antigen Presentation), which suppresses vial antigen presentation by class I MHC and the ability of cytotoxic T lymphocytes to clear viral infections...
  36. Using the MHC class I cytoplasmic tail to control tumor Ag presentation by DCs
    Gregory A Lizee; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Immunotherapies that utilize cytotoxic T lymphocytes (CTLs) have proven effective at eradicating large tumor burdens in both animal models and human cancer patients...
  37. Cellular Immunity to JC Virus in AIDS-Associated Progressive Multifocal Leukoence
    Igor J Koralnik; Fiscal Year: 2010
    ..We have identified epitopes of JCV recognized by CD8+ cytotoxic T lymphocytes (CTL) of HLA A2+ patients and shown that despite their low frequency in peripheral blood, these cells are ..
  38. Viral Constraints on SIV Escape from Cytotoxic T Lymphocytes
    WENDY WEN LI YEH; Fiscal Year: 2010
    ..b>Cytotoxic T lymphocytes (CTL) play a central role in controlling human immunodeficiency virus (HIV) infection in humans and ..
  39. Tumor-produced TNF alpha as an inducer of immune resistance and tumor survival
    ELENA LEVITSKAIA; Fiscal Year: 2013
    ..Characterization of TNF function in neuroblastoma will prompt investigations on the role of this cytokine in the pathogenesis of other tumors. ..
  40. Mechanisms and optimization of epitope presentation by HIV-infectable cell subset
    Sylvie Le Gall; Fiscal Year: 2013
    ..abstract_text> ..
  41. SPOTTED FEVER RICKETTSIAL ANTIGENS
    David H Walker; Fiscal Year: 2013
    ..Excellent animal models and the available human data reveal the critical importance of IFN-gamma, CD8 cytotoxic T lymphocytes, dendritic cells (DCs) and NK cells in host protective immunity against Rickettsia...
  42. Kupffer Cells in Liver Immunopathology
    Ian Nicholas Crispe; Fiscal Year: 2010
    ..Furthermore, we postulate that KC-mediated killing of anti-viral cytotoxic T lymphocytes (CTLs) inhibits the antiviral CTL response (Aim 2) and that KC-mediated bystander effect contributes to ..
  43. Adoptive Transfer of AlloCTL for Immunotherapy of Recurrent Gliomas
    Linda M Liau; Fiscal Year: 2013
    ..have achieved both pre-clinical and clinical success with adoptive transfer of intracavitary alloreactive cytotoxic T lymphocytes (aCTL), which are sensitized to the tumor host's human leukocyte antigens (HLA)...
  44. Mechanisms Underlying Persistent Lentivirus Replication in Follicular T Cells
    Pamela J Skinner; Fiscal Year: 2013
    ..Reasons why lentiviruses are preferentially replicated by follicular CD4+ T cells and why virus-specific cytotoxic T lymphocytes (CTL) cannot suppress replication in these cells are not understood...
  45. Targeting EGFRvIII in Brain Tumors with Bispecific Antibodies
    Bryan Choi; Fiscal Year: 2013
    ..Substantial evidence suggests that T cells, particularly cytotoxic T lymphocytes (CTLs), have the ability to eradicate large, well-established tumors while leaving healthy cells ..
  46. Impact of Highly Active T Lymphocytes from Induced Pluripotent Stem Cells
    Jianxun Song; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Adoptive cell transfer (ACT) of antigen (Ag)-specific CD8+ cytotoxic T lymphocytes (CTLs) is a promising treatment for a variety of malignancies...
  47. Regulatory Immune Cell Networks in Cancer
    THORSTEN ROMAN MEMPEL; Fiscal Year: 2013
    ..is critical for their immunosuppressive function on anti-tumor effector cells, most prominently CD8+ cytotoxic T lymphocytes (CTL)...
  48. Nanog as a gateway to the immune-suppressive state in cancer
    Chih Ping Mao; Fiscal Year: 2013
    ..phenotype to these cancer cells, and inhibition of Nanog leads to tumor eradication by CD8+ cytotoxic T lymphocytes (CTLs) in mice...
  49. IMMUNOPATHOGENESIS OF LUPUS
    Charles S Via; Fiscal Year: 2012
    ..This application pursues the novel hypothesis that cytotoxic T lymphocytes (CTL) are an important early mechanism that limits breaks in tolerance to nuclear antigens and prevents ..
  50. Discovery and Targeting of West Nile Virus Epitopes
    William Hildebrand; Fiscal Year: 2013
    ..b>Cytotoxic T lymphocytes which continuously scan class I HLA at the cell surface are able to single out class I HLA carrying virus-..
  51. SPORE in Lymphoma
    Helen E Heslop; Fiscal Year: 2013
    ..new target antigens in Hodgkin's lymphoma, particularly cancer testis antigens, before testing cytotoxic T lymphocytes (CTLs) specific for these targets in patients with relapsed disease. Drs...
  52. Towards Structural Studies of Aminopeptidases in Antigen Processing
    Hwai Chen Guo; Fiscal Year: 2010
    ..peptides processed from viral proteins synthesized within infected cells, and present those peptides to cytotoxic T lymphocytes (CTLs), which can eliminate the infected cells and thus eliminate potential sources of new viral ..
  53. Pathogenesis of autoimmune myositis: Role of MHC Class 1
    Kanneboyina Nagaraju; Fiscal Year: 2009
    ..propose that skeletal muscle cell damage in MHC class I expressing muscle fibers can partly be induced by cytotoxic T lymphocytes and partly by perturbation of intracellular homeostasis (ER stress response)...
  54. THE ROLE OF CTL ESCAPE MUTATIONS IN ATTENUATING HIV-1 SUBTYPE C INFECTION
    Carolyn Williamson; Fiscal Year: 2011
    ..This project was previously funded through CIPRA (U19 A151794-01). . ..
  55. Local Therapy-A Novel Approach to Cancer Metastases
    Lisa Wei; Fiscal Year: 2009
    ..This grant application proposes a novel strategy to combat metastases by leveraging the tumor stroma and utilizing it to stimulate the immune system to eradicate both tumors and metastases. ..
  56. Enhancement of stem cell transplants using CAR.CD30-redirected T lymphocytes
    Barbara Savoldo; Fiscal Year: 2013
    ..after transplant remains a highly desirable objective and the adoptive transfer of antigen/tumor-specific cytotoxic T lymphocytes (CTLs) is one promising approach...
  57. Role of CXCR3 for CD8+ T cells in cancer immunotherapy
    David W Mullins; Fiscal Year: 2013
    ..of most clinical immunotherapy trials has been to generate maximal numbers of circulating tumor- specific cytotoxic T lymphocytes (CTL), predicated on the notion that "more is better...
  58. INHIBITION OF HIV 1 REPLICATION BY CYTOTOXIC LYMPHOCYTES
    Bruce D Walker; Fiscal Year: 2013
    ..The aim of this project is to understand how specific cells of the immune system, called cytotoxic T lymphocytes (CTL), identify and kill virus- infected cells, and to define the most vulnerable proteins of the virus ..
  59. Protein Signature in Memory CTL Differentiation
    Zhengguo Xiao; Fiscal Year: 2013
    ..goal is to understand the molecular and cellular mechanisms for the generation of functional memory cytotoxic T lymphocytes (CTLs) for the purpose of developing more effective vaccines...
  60. TGFbeta Blockade in MART TCR-Engineered T Cell Melanoma Immunotherapy in Man
    Richard C Koya; Fiscal Year: 2013
    ..We hypothesize that these highly activated and cytotoxic T lymphocytes, when entering an immunosuppressive tumor microenvironment, lose their effector function over time...
  61. MHC-BOUND, SIV-DERIVED, CTL AND HTL EPITOPES
    David I Watkins; Fiscal Year: 2011
    ..Given the important role that cytotoxic T lymphocytes (CTLs) and helper T lymphocytes (HTLs) play in controlling viral replication, it is critical that this ..
  62. Identification of biomarkers of fatty acid intake
    Hannia Campos; Fiscal Year: 2002
    ..toxicity, and efficacy of treating patients with relapsed follicular lymphomas with autologous CD8+ cytotoxic T lymphocytes (CTL) which have been genetically modified to express a chimeric T cell receptor recognizing the CD20 ..
  63. TH1 CYTOKINES AND IMPAIRED CD8* CTLS IN ELDERLY
    Innocent Mbawuike; Fiscal Year: 2001
    ..the Applicant's Abstract): The objectives of this proposal are to determine the mechanisms of deficient cytotoxic T lymphocytes (CD8+ CTL) activity against influenza virus among elderly persons and how this deficiency can be ..
  64. EPITOPES RECOGNIZED BY CTL FROM EIAV CARRIER HORSES
    SHERITTA RIDGELY; Fiscal Year: 2000
    ..Identification of viral epitopes recognized by CD8+, class I-restricted cytotoxic T lymphocytes in carrier horses and the ability of identified epitopes to induce protective immunity in horses will be ..
  65. HIV-1 Specific Cytotoxic T Lymphocytes in Breastmilk
    Grace John Stewart; Fiscal Year: 2003
    ..Some uninfected infants born to HIV-1 infected women generate HIV-1 specific cytotoxic T lymphocytes (CTLs), suggesting viral antigenic exposure sufficient to induce immunity but not to establish infection...
  66. SEQUENCING OF CLASS I MHC PEPTIDES BY MASS SPECTROMETRY
    Robert Cotter; Fiscal Year: 1999
    ..on cell surfaces by Class I MHC (multiple histocompatibility [Sic ]) molecules for recognition by cytotoxic T lymphocytes (CTL) or killer T cells...
  67. SPECIFIC ACTIVE IMMUNOTHERAPY OF HUMAN MELANOMA
    Malcolm Mitchell; Fiscal Year: 1993
    ..melanoma in 20% of patients, with a median response of 17 mo, associated with a rise in precursors of cytotoxic T lymphocytes (pCTL)...
  68. New Approaches to the Biology and Treatment of Myelodysplastic Syndromes (MDS)
    Hagop Kantarjian; Fiscal Year: 2009
    ..Achievement of these goals will be facilitated by the 240 patients seen annually at M.D. Anderson and the frequency with which these patients return for follow-up. ..
  69. HTLV Deregulation of CD40(L) in Cancer&Neurodegeneration
    Edward Harhaj; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): The cellular immune response mediated by cytotoxic T lymphocytes (CTLs) plays a critical role in the identification and clearance of human T cell lymphotropic virus type I (HTLV-I)-..
  70. CHEMOKINES IN CTL FUNCTION AND TRAFFICKING IN HIV
    Andrew Luster; Fiscal Year: 2004
    b>Cytotoxic T lymphocytes (CTL) play a critical role in host defense against viral infections, including HIV-1. Chemokines play an important role in several aspects of CTL function as CTL both produce and respond to chemokines...
  71. T CELL IMMUNE RESPONSE TO BREAST CARCINOMA
    Timothy Eberlein; Fiscal Year: 1999
    ..This cytolytic activity was mediated through the T cell receptor on CD8+ cytotoxic T lymphocytes (CTL) that bound to antigenic peptides presented by HLA-A2 molecules expressed on the tumor cells...
  72. CTL DEVELOPMENT BY L-ORNITHINE AND POLYAMINES
    Brian Susskind; Fiscal Year: 1990
    L-Ornithine has been shown to inhibit the development of cytotoxic T lymphocytes (CTL) in mixed lymphocyte cultures (MLC)...
  73. Nanoengineered HIV-1 Vaccines Based on Tat
    RUSSELL MUMPER; Fiscal Year: 2004
    ..Tat is efficiently processed by major histocompatibility complex (MHC) class I for presentation to cytotoxic T lymphocytes (CTL)...
  74. Inhibition of CTL killing by HSV
    KEITH JEROME; Fiscal Year: 2005
    ..One mechanism by which the host attempts to induce apoptosis of infected cells is through the action of cytotoxic T lymphocytes (Cm)...
  75. ANTIGENIC DETERMINENTS ON HLA-B7 AND HLA-A2
    VICTOR ENGELHARD; Fiscal Year: 2001
    ..to be the nature of the antigenic determinants on human MHC class molecules that are recognized by cytotoxic T lymphocytes (CTL)...
  76. ROLE OF FUCOSYLTRANSEFERASE IN ANTIVIRAL CYTOTOXICITY
    MANJUNATH SWAMY; Fiscal Year: 2000
    b>Cytotoxic T lymphocytes (CTL) are key immune effector cells in controlling viral infections and tumors. However, their differentiation in vivo is only partially understood...
  77. 2009 Antigen Cross Presentation Gordon-sponsored Meeting
    Stephen Schoenberger; Fiscal Year: 2009
    ..Background: Cytotoxic T lymphocytes (CTLs) represent a critical component of the adaptive immune response against viruses, intracellular ..
  78. MACROPHAGE ANTIGEN PROCESSING OF HIV SUBTYPES
    Kenneth Knox; Fiscal Year: 2005
    Adapted from applicant?s abstract) CD8+, MHC-1 restricted cytotoxic T lymphocytes (CTL) are responsible for controlling viremia associated with human immunodeficiency virus (HIV) infection...