t lymphocyte subsets

Summary

Summary: A classification of T-lymphocytes, especially into helper/inducer, suppressor/effector, and cytotoxic subsets, based on structurally or functionally different populations of cells.

Top Publications

  1. ncbi Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
    F Sallusto
    Basel Institute for Immunology, Switzerland
    Nature 401:708-12. 1999
  2. ncbi Central memory and effector memory T cell subsets: function, generation, and maintenance
    Federica Sallusto
    Institute for Research in Biomedicine, CH 6500 Bellinzona, Switzerland
    Annu Rev Immunol 22:745-63. 2004
  3. ncbi Control of regulatory T cell development by the transcription factor Foxp3
    Shohei Hori
    Laboratory of Immunopathology, Research Center for Allergy and Immunology, Institute for Physical and Chemical Research, Yokohama 230 0045, Japan
    Science 299:1057-61. 2003
  4. ncbi Development, cytokine profile and function of human interleukin 17-producing helper T cells
    Nicholas J Wilson
    Department of Discovery Research, Schering Plough Biopharma Formerly DNAX Research, Palo Alto, California 94304 1104, USA
    Nat Immunol 8:950-7. 2007
  5. ncbi Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells
    Eva V Acosta-Rodriguez
    Institute for Research in Biomedicine, CH 6500 Bellinzona, Switzerland
    Nat Immunol 8:942-9. 2007
  6. ncbi CD1d-restricted and TCR-mediated activation of valpha14 NKT cells by glycosylceramides
    T Kawano
    CREST Core Research for Evolutional Science and Technology Project, Japan Science and Technology Corporation JST, 1 8 1 Inohana, Chuo, Chiba 260, Japan
    Science 278:1626-9. 1997
  7. ncbi Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells
    Susan M Kaech
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, 1510 Clifton Road, Atlanta, Georgia 30322, USA
    Nat Immunol 4:1191-8. 2003
  8. ncbi Antigen-specific T cell sensitization is impaired in IL-17-deficient mice, causing suppression of allergic cellular and humoral responses
    Susumu Nakae
    Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo, Japan
    Immunity 17:375-87. 2002
  9. ncbi Transient expression of FOXP3 in human activated nonregulatory CD4+ T cells
    Jun Wang
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    Eur J Immunol 37:129-38. 2007
  10. ncbi Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
    S Sakaguchi
    Precursory Research for Embryonic Science and Technology PRESTO, Research and Development Corporation of Japan JRDC, Tsukuba Life Science Center
    J Immunol 155:1151-64. 1995

Detail Information

Publications331 found, 100 shown here

  1. ncbi Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
    F Sallusto
    Basel Institute for Immunology, Switzerland
    Nature 401:708-12. 1999
    ....
  2. ncbi Central memory and effector memory T cell subsets: function, generation, and maintenance
    Federica Sallusto
    Institute for Research in Biomedicine, CH 6500 Bellinzona, Switzerland
    Annu Rev Immunol 22:745-63. 2004
    ..This review addresses the heterogeneity of TCM and TEM, their differentiation stages, and the current models for their generation and maintenance in humans and mice...
  3. ncbi Control of regulatory T cell development by the transcription factor Foxp3
    Shohei Hori
    Laboratory of Immunopathology, Research Center for Allergy and Immunology, Institute for Physical and Chemical Research, Yokohama 230 0045, Japan
    Science 299:1057-61. 2003
    ..Thus, Foxp3 is a key regulatory gene for the development of regulatory T cells...
  4. ncbi Development, cytokine profile and function of human interleukin 17-producing helper T cells
    Nicholas J Wilson
    Department of Discovery Research, Schering Plough Biopharma Formerly DNAX Research, Palo Alto, California 94304 1104, USA
    Nat Immunol 8:950-7. 2007
    ..Our data collectively indicate that human and mouse T(H)-17 cells require distinct factors during differentiation and that human T(H)-17 cells may regulate innate immunity in epithelial cells...
  5. ncbi Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells
    Eva V Acosta-Rodriguez
    Institute for Research in Biomedicine, CH 6500 Bellinzona, Switzerland
    Nat Immunol 8:942-9. 2007
    ....
  6. ncbi CD1d-restricted and TCR-mediated activation of valpha14 NKT cells by glycosylceramides
    T Kawano
    CREST Core Research for Evolutional Science and Technology Project, Japan Science and Technology Corporation JST, 1 8 1 Inohana, Chuo, Chiba 260, Japan
    Science 278:1626-9. 1997
    ..Thus, this lymphocyte shares distinct recognition systems with either T or NK cells...
  7. ncbi Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells
    Susan M Kaech
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, 1510 Clifton Road, Atlanta, Georgia 30322, USA
    Nat Immunol 4:1191-8. 2003
    ..Thus, selective expression of IL-7R identifies memory cell precursors, and this marker may be useful in predicting the number of memory T cells generated after infection or immunization...
  8. ncbi Antigen-specific T cell sensitization is impaired in IL-17-deficient mice, causing suppression of allergic cellular and humoral responses
    Susumu Nakae
    Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo, Japan
    Immunity 17:375-87. 2002
    ..Our findings indicate that IL-17 plays an important role in activating T cells in allergen-specific T cell-mediated immune responses...
  9. ncbi Transient expression of FOXP3 in human activated nonregulatory CD4+ T cells
    Jun Wang
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    Eur J Immunol 37:129-38. 2007
    ..These data indicate that expression of endogenous FOXP3, in humans, is not sufficient to induce regulatory T cell activity or to identify T(reg) cells...
  10. ncbi Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
    S Sakaguchi
    Precursory Research for Embryonic Science and Technology PRESTO, Research and Development Corporation of Japan JRDC, Tsukuba Life Science Center
    J Immunol 155:1151-64. 1995
    ..Abnormality of this T cell-mediated mechanism of peripheral tolerance can be a possible cause of various autoimmune diseases...
  11. ncbi Phenotype and function of human T lymphocyte subsets: consensus and issues
    Victor Appay
    Cellular Immunology Laboratory, INSERM U543, Avenir Group, Hopital Pitie Salpetriere, Universite Pierre et Marie Curie PARIS6, 75013 Paris, France
    Cytometry A 73:975-83. 2008
    ..Finally, we discuss the problems which still limit general agreement...
  12. ncbi Transforming growth factor-beta regulation of immune responses
    Ming O Li
    Section of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Annu Rev Immunol 24:99-146. 2006
    ..This review highlights the findings that have advanced our understanding of TGF-beta in the immune system and in disease...
  13. ncbi Exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections
    Jochen Mattner
    Committee on Immunology, University of Chicago, Chicago, Illinois 60637, USA
    Nature 434:525-9. 2005
    ..These findings identify two novel antigenic targets of NKT cells in antimicrobial defence, and show that glycosylceramides are an alternative to LPS for innate recognition of the Gram-negative, LPS-negative bacterial cell wall...
  14. pmc Identification and functional characterization of human CD4(+)CD25(+) T cells with regulatory properties isolated from peripheral blood
    H Jonuleit
    Department of Dermatology, University of Mainz, D 55101 Mainz, Germany
    J Exp Med 193:1285-94. 2001
    ..However, the refractory state of CD4(+)CD25(+) T cells was partially reversible by the addition of IL-2 or IL-4. These data demonstrate that human blood contains a resident T cell population with potent regulatory properties...
  15. pmc Interleukin-22 but not interleukin-17 provides protection to hepatocytes during acute liver inflammation
    Lauren A Zenewicz
    Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Immunity 27:647-59. 2007
    ..Our data suggest that IL-22 serves as a protective molecule to counteract the destructive nature of the immune response to limit tissue damage...
  16. pmc IL-4 inhibits TGF-beta-induced Foxp3+ T cells and, together with TGF-beta, generates IL-9+ IL-10+ Foxp3(-) effector T cells
    Valerie Dardalhon
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Cambridge, Massachusetts 02139, USA
    Nat Immunol 9:1347-55. 2008
    ..Thus IL-9(+)IL-10(+) T cells lack suppressive function and constitute a distinct population of helper-effector T cells that promote tissue inflammation...
  17. pmc Late developmental plasticity in the T helper 17 lineage
    Yun Kyung Lee
    Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Immunity 30:92-107. 2009
    ..These results support a model of late Th17 developmental plasticity with implications for autoimmunity and host defense...
  18. ncbi Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid
    Daniel Mucida
    La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA
    Science 317:256-60. 2007
    ..These findings indicate that a common metabolite can regulate the balance between pro- and anti-inflammatory immunity...
  19. pmc Global mapping of H3K4me3 and H3K27me3 reveals specificity and plasticity in lineage fate determination of differentiating CD4+ T cells
    Gang Wei
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 30:155-67. 2009
    ..Our data suggest an epigenetic mechanism underlying the specificity and plasticity of effector and regulatory T cells and also provide a framework for understanding complexity of CD4(+) T helper cell differentiation...
  20. ncbi Immunology of tuberculosis
    J L Flynn
    Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Annu Rev Immunol 19:93-129. 2001
    ..The pace of this research must be maintained if we are to realize an effective vaccine in the next decades...
  21. ncbi Recognition of bacterial glycosphingolipids by natural killer T cells
    Yuki Kinjo
    Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, San Diego, 10355 Science Center Drive, San Diego, California 92121, USA
    Nature 434:520-5. 2005
    ....
  22. ncbi Inhibiting Stat3 signaling in the hematopoietic system elicits multicomponent antitumor immunity
    Marcin Kortylewski
    H Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, Florida 33612, USA
    Nat Med 11:1314-21. 2005
    ..Our findings show that Stat3 signaling restrains natural tumor immune surveillance and that inhibiting hematopoietic Stat3 in tumor-bearing hosts elicits multicomponent therapeutic antitumor immunity...
  23. ncbi Recognition of stress-induced MHC molecules by intestinal epithelial gammadelta T cells
    V Groh
    Fred Hutchinson Cancer Research Center, Clinical Research Division, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    Science 279:1737-40. 1998
    ..Thus, these molecules may broadly regulate protective responses by the Vdelta1 gammadelta T cells in the epithelium of the intestinal tract...
  24. ncbi Transforming growth factor-beta 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9-producing subset
    Marc Veldhoen
    Division of Molecular Immunology, Medical Research Council National Institute for Medical Research, London NW7 1AA, UK
    Nat Immunol 9:1341-6. 2008
    ..Thus, transforming growth factor-beta constitutes a regulatory 'switch' that in combination with other cytokines can 'reprogram' effector T cell differentiation along different pathways...
  25. ncbi NKT cells: what's in a name?
    Dale I Godfrey
    Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria 3010, Australia
    Nat Rev Immunol 4:231-7. 2004
  26. pmc T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma
    Xuexian O Yang
    Department of Immunology, M D Anderson Cancer Center, Houston, TX 77030, USA
    Immunity 28:29-39. 2008
    ..Therefore, Th17 differentiation is directed by two lineage-specific nuclear receptors, ROR alpha and ROR gamma...
  27. ncbi IL-25 induces IL-4, IL-5, and IL-13 and Th2-associated pathologies in vivo
    M M Fort
    DNAX Research Institute, Palo Alto, CA 94304, USA
    Immunity 15:985-95. 2001
    ..These results suggest that IL-25, derived from Th2 T cells, is capable of amplifying allergic type inflammatory responses by its actions on other cell types...
  28. pmc Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells
    Nabila Seddiki
    Centenary Institute of Cancer Medicine and Cell Biology, Faculty of Medicine, University of Sydney, Newtown, NSW 2042, Australia
    J Exp Med 203:1693-700. 2006
    ....
  29. pmc The biological functions of T helper 17 cell effector cytokines in inflammation
    Wenjun Ouyang
    Department of Immunology, Genentech, 1 DNA Way, South San Francisco, California 94080, USA
    Immunity 28:454-67. 2008
    ..The effector cytokines of Th17 cells, therefore, mediate the crucial crosstalk between immune system and tissues, and play indispensable roles in tissue immunity...
  30. pmc Molecular antagonism and plasticity of regulatory and inflammatory T cell programs
    Xuexian O Yang
    Department of Immunology, M D Anderson Cancer Center, Houston, TX 77030, USA
    Immunity 29:44-56. 2008
    ..STAT3 regulated Foxp3 downregulation, whereas STAT3, RORgamma, and ROR* were required for IL-17 expression in Treg cells. Our data demonstrate molecular antagonism and plasticity of Treg and Th17 cell programs...
  31. pmc IL-9 as a mediator of Th17-driven inflammatory disease
    Elizabeth C Nowak
    Department of Microbiology and Immunology, Dartmouth Medical School and the Norris Cotton Cancer Center, Lebanon, NH 03756, USA
    J Exp Med 206:1653-60. 2009
    ..Collectively, these data implicate IL-9 as a Th17-derived cytokine that can contribute to inflammatory disease...
  32. ncbi The VITAL assay: a versatile fluorometric technique for assessing CTL- and NKT-mediated cytotoxicity against multiple targets in vitro and in vivo
    Ian F Hermans
    Tumour Immunology Unit, Nuffield Department of Medicine, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK
    J Immunol Methods 285:25-40. 2004
    ..The VITAL assay is, therefore, a sensitive technique allowing analysis of complex multi-epitope responses...
  33. ncbi Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance
    Jun Shimizu
    Department of Immunopathology, Tokyo Metropolitan Institute of Gerontology, Tokyo 173 0015, Japan
    Nat Immunol 3:135-42. 2002
    ..Thus, GITR plays a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells and could be a suitable molecular target for preventing or treating autoimmune disease...
  34. pmc Th17 cells promote pancreatic inflammation but only induce diabetes efficiently in lymphopenic hosts after conversion into Th1 cells
    Natalia Martin-Orozco
    Department of Immunology, MD Anderson Cancer Center, Houston, TX 77030, USA
    Eur J Immunol 39:216-24. 2009
    ..These results indicate that islet-reactive Th17 cells promote pancreatic inflammation, but only induce IDDM upon conversion into IFN-gamma producers...
  35. ncbi Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity
    P Bouillet
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia
    Science 286:1735-8. 1999
    ..Thus, Bim is required for hematopoietic homeostasis and as a barrier to autoimmunity. Moreover, particular death stimuli appear to activate apoptosis through distinct BH3-only proteins...
  36. ncbi CD8 T cell dysfunction during chronic viral infection
    Haina Shin
    Immunology Program, The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA
    Curr Opin Immunol 19:408-15. 2007
    ..In this review, we will discuss recent work that highlights two main types of T cell dysfunction during chronic infection: exhaustion of effector functions and altered memory T cell development...
  37. pmc Essential role for CD103 in the T cell-mediated regulation of experimental colitis
    Oliver Annacker
    Sir William Dunn School of Pathology, University of Oxford, OX1 3RE, England, UK
    J Exp Med 202:1051-61. 2005
    ..Collectively, these data suggest that CD103+ and CD103- DCs represent functionally distinct subsets and that CD103 expression on DCs influences the balance between effector and regulatory T cell activity in the intestine...
  38. pmc Th17 cells in human disease
    Laura A Tesmer
    Department of Internal Medicine, Division of Rheumatology, Rheumatic Disease Core Center, University of Michigan, Ann Arbor, MI 48109 5358, USA
    Immunol Rev 223:87-113. 2008
    ....
  39. ncbi Toward an understanding of NKT cell biology: progress and paradoxes
    Mitchell Kronenberg
    La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    Annu Rev Immunol 23:877-900. 2005
    ..Despite this uncertainty, many investigators are hopeful that immune therapies can be developed based on NKT cell stimulation...
  40. pmc Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma
    Giao Q Phan
    Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 100:8372-7. 2003
    ..This study establishes CTLA-4 as an important molecule regulating tolerance to "self" antigens in humans and suggests a role for CTLA-4 blockade in breaking tolerance to human cancer antigens for cancer immunotherapy...
  41. pmc A crucial role for interleukin (IL)-1 in the induction of IL-17-producing T cells that mediate autoimmune encephalomyelitis
    Caroline Sutton
    Immune Regulation Research Group, School of Biochemistry and Immunology, Trinity College, Dublin 2, Ireland
    J Exp Med 203:1685-91. 2006
    ..Tumor necrosis factor alpha also synergized with IL-23 to enhance IL-17 production, and this was IL-1 dependent. Our findings demonstrate that IL-1 functions upstream of IL-17 to promote pathogenic ThIL-17 cells in EAE...
  42. pmc Expression of the integrin alpha Ebeta 7 identifies unique subsets of CD25+ as well as CD25- regulatory T cells
    Joachim Lehmann
    Experimentelle Rheumatologie, Universitatsklinikum Charite, Humboldt Universitat, c o Deutsches Rheumaforschungszentrum, 10117 Berlin, Germany
    Proc Natl Acad Sci U S A 99:13031-6. 2002
    ..Thus, the integrin alpha(E)beta(7) can be regarded as a novel marker for subsets of highly potent, functionally distinct regulatory T cells specialized for crosstalk with epithelial environments...
  43. ncbi Regulation of cutaneous malignancy by gammadelta T cells
    M Girardi
    Department of Dermatology and Yale Skin Diseases Research Core Center, King s College, London SE1 9RT, UK
    Science 294:605-9. 2001
    ..Thus, local T cells may use evolutionarily conserved proteins to negatively regulate malignancy...
  44. pmc Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction
    Kojiro Sato
    Department of Cell Signaling, Graduate School, and COE Program for Frontier Research on Molecular Destruction and Reconstruction of Tooth and Bone, Tokyo Medical and Dental University, Tokyo 113 8549, Japan
    J Exp Med 203:2673-82. 2006
    ..Thus, Th17 is a powerful therapeutic target for the bone destruction associated with T cell activation...
  45. pmc Selective expression of IL-7 receptor on memory T cells identifies early CD40L-dependent generation of distinct CD8+ memory T cell subsets
    Katharina M Huster
    Institute for Medical Microbiology, Immunology, and Hygiene, Technical University of Munich, 81675 Munich, Germany
    Proc Natl Acad Sci U S A 101:5610-5. 2004
    ....
  46. ncbi Inducing and expanding regulatory T cell populations by foreign antigen
    Karsten Kretschmer
    Department of Pathology, Harvard Medical School, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Nat Immunol 6:1219-27. 2005
    ..The extrathymic generation and proliferation of regulatory T cells may contribute to self-tolerance as well as the poor immunogenicity of tumors and may be exploited clinically to prevent or reverse unwanted immunity...
  47. ncbi Regulatory T cell lineage specification by the forkhead transcription factor foxp3
    Jason D Fontenot
    Department of Immunology, University of Washington, Seattle, Washington 98195, USA
    Immunity 22:329-41. 2005
    ..Analysis of Foxp3 expression during thymic development suggests that this mechanism is not hard-wired but is dependent on TCR/MHC ligand interactions...
  48. ncbi Impaired effector function of hepatitis C virus-specific CD8+ T cells in chronic hepatitis C virus infection
    Heiner Wedemeyer
    Liver Diseases Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 169:3447-58. 2002
    ..Thus, the defective functions of HCV-specific CD8+ T cells might contribute to viral persistence in chronically infected patients, and knowledge on their reversibility may facilitate the development of immunotherapeutic vaccines...
  49. ncbi Human CD4(+)CD25(+) cells: a naturally occurring population of regulatory T cells
    W F Ng
    Department of Immunology, Hammersmith Campus, Imperial College School of Medicine, London, United Kingdom
    Blood 98:2736-44. 2001
    ..Comparison with rodent CD4(+)CD25(+) cells suggests that this population may play a key role in the prevention of autoimmune diseases in humans...
  50. ncbi Preferential localization of effector memory cells in nonlymphoid tissue
    D Masopust
    Division of Immunology, Department of Medicine, University of Connecticut Health Center, Farmington, CT 06030, USA
    Science 291:2413-7. 2001
    ..These results point to the existence of a population of extralymphoid effector memory T cells poised for immediate response to infection...
  51. pmc Cutting edge: NKT cells constitutively express IL-23 receptor and RORgammat and rapidly produce IL-17 upon receptor ligation in an IL-6-independent fashion
    Aleksandra V Rachitskaya
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 180:5167-71. 2008
    ..These data suggest an important biological role for innate IL-17 production by NKT cells that is rapid and precedes the adaptive IL-17 response...
  52. pmc Differential tumor surveillance by natural killer (NK) and NKT cells
    M J Smyth
    Cellular Cytotoxicity Laboratory, Austin Research Institute, Austin and Repatriation Medical Centre, Heidelberg, 3084 Victoria, Australia
    J Exp Med 191:661-8. 2000
    ..This is the first description of an antitumor function for NKT cells in the absence of exogenously administered potent stimulators such as IL-12 or alpha-galactosylceramide...
  53. ncbi IFN-alpha and IL-10 induce the differentiation of human type 1 T regulatory cells
    M K Levings
    San Raffaele Telethon Institute for Gene Therapy (HSR-TIGET, Milan, Italy
    J Immunol 166:5530-9. 2001
    ....
  54. ncbi IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways
    Liang Zhou
    The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, New York 10016, USA
    Nat Immunol 8:967-74. 2007
    ..IL-6 therefore orchestrates a series of 'downstream' cytokine-dependent signaling pathways that, in concert with TGF-beta, amplify RORgammat-dependent differentiation of T(H)-17 cells...
  55. pmc CD4+CD25+ T cells regulate virus-specific primary and memory CD8+ T cell responses
    Susmit Suvas
    Department of Microbiology, University of Tennessee, Knoxville, TN 37996 0845, USA
    J Exp Med 198:889-901. 2003
    ..Thus, controlling suppressor effects at the time of vaccination could result in more effective immunity...
  56. pmc Rapid acquisition of tissue-specific homing phenotypes by CD4(+) T cells activated in cutaneous or mucosal lymphoid tissues
    Daniel J Campbell
    Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Exp Med 195:135-41. 2002
    ....
  57. ncbi Neuropilin-1: a surface marker of regulatory T cells
    Dunja Bruder
    Eur J Immunol 34:623-30. 2004
    ..Thus, Nrp1 constitutes a useful surface marker to distinguish Treg cells from both naive and recently activated CD4+CD25+ non-regulatory T cells...
  58. ncbi NKT cells: facts, functions and fallacies
    D I Godfrey
    Dept of Pathology and Immunology, Monash University Medical School, Commercial Road, VIC 3181, Prahran, Australia
    Immunol Today 21:573-83. 2000
    ..Heterogeneity of these cells contributes to the controversy surrounding their development and function. This review aims to provide an update on NKT cell biology and, whenever possible, to compare what is known about NKT-cell subsets...
  59. pmc Thymic selection determines gammadelta T cell effector fate: antigen-naive cells make interleukin-17 and antigen-experienced cells make interferon gamma
    Kirk D C Jensen
    Department of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA
    Immunity 29:90-100. 2008
    ..The swift IL-17 response mounted by antigen-naive gammadelta T cells suggests a critical role for these cells at the onset of an acute inflammatory response to novel antigens...
  60. pmc Cytokine-driven proliferation and differentiation of human naive, central memory, and effector memory CD4(+) T cells
    J Geginat
    Institute for Research in Biomedicine, Bellinzona 6500, Switzerland
    J Exp Med 194:1711-9. 2001
    ..The sustained antigen-independent generation of T(EM) from a pool of T(CM) cells provides a plausible mechanism for the maintenance of a polyclonal and functionally diverse repertoire of human CD4(+) memory T cells...
  61. ncbi CD25- T cells generate CD25+Foxp3+ regulatory T cells by peripheral expansion
    Maria A Curotto de Lafaille
    Molecular Pathogenesis Program, Skirball Institute, and Department of Pathology, New York University School of Medicine, New York, NY 10016, USA
    J Immunol 173:7259-68. 2004
    ..The maintenance of CD25 expression by CD4(+)CD25(+) cells depends on IL-2 secreted by cotransferred CD4(+)CD25(-) or by Ag-stimulated T cells in peripheral lymphoid organs...
  62. ncbi CD1d1 mutant mice are deficient in natural T cells that promptly produce IL-4
    S K Mendiratta
    Howard Hughes Medical Institute, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Immunity 6:469-77. 1997
    ..These results demonstrate a critical role for CD1 in the positive selection and function of NT cells...
  63. ncbi Cutting edge: control of CD8+ T cell activation by CD4+CD25+ immunoregulatory cells
    C A Piccirillo
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
    J Immunol 167:1137-40. 2001
    ....
  64. ncbi Galectins and their ligands: amplifiers, silencers or tuners of the inflammatory response?
    Gabriel A Rabinovich
    Division of Immunogenetics, Hospital de Clinicas Jose de San Martin, School of Medicine, University of Buenos Aires, Cordoba 2351, 3er Piso 1120, Buenos Aires, Argentina
    Trends Immunol 23:313-20. 2002
    ..The current wealth of new information promises a future scenario in which individual members of the galectin family or their ligands will be used as powerful anti-inflammatory mediators and selective modulators of the immune response...
  65. pmc Selective generation of gut tropic T cells in gut-associated lymphoid tissue (GALT): requirement for GALT dendritic cells and adjuvant
    Bengt Johansson-Lindbom
    Immunology Section, Dept of Cell and Molecular Biology, Lund University, BMC I 13, S 22184 Lund, Sweden
    J Exp Med 198:963-9. 2003
    ..Together, these results demonstrate that GALT DCs and T cell expression of CCR9 play critical and integrated roles during T cell homing to the gut...
  66. ncbi Crucial role of the pre-T-cell receptor alpha gene in development of alpha beta but not gamma delta T cells
    H J Fehling
    Basel Institute of Immunology, Switzerland
    Nature 375:795-8. 1995
    ..Here we show that alpha beta, but not gamma delta, cell development is severely hampered in pre-T-cell-receptor alpha-gene-deficient mice, which establishes a crucial role for the pre-T-cell receptor in early thymocyte development...
  67. ncbi IL-17 production is dominated by gammadelta T cells rather than CD4 T cells during Mycobacterium tuberculosis infection
    Euan Lockhart
    Department of Molecular Genetics and Biochemistry, Biomedical Science Tower, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    J Immunol 177:4662-9. 2006
    ..tuberculosis-infected dendritic cells. IL-23 is present in the lungs early in infection and the IL-17-producing cells, such as gammadelta T cells, may represent a central innate protective response to pulmonary infection...
  68. ncbi A role for CD40 expression on CD8+ T cells in the generation of CD8+ T cell memory
    Christine Bourgeois
    INSERM U345, Institut Necker, 156 rue de Vaugirard, F 75730 Paris Cedex 15, France
    Science 297:2060-3. 2002
    ..These results suggest that, like B cells, CD8+ T cells receive CD4 help directly through CD40 and that this interaction is fundamental for CD8+ T cell memory generation...
  69. pmc Major histocompatibility complex class I-recognizing receptors are disease risk genes in rheumatoid arthritis
    J H Yen
    Department of Medicine and the Department of Immunology, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Exp Med 193:1159-67. 2001
    ..Specifically, KIR2DS2 in conjunction with the appropriate HLA-C ligand may have a role in vascular damage by regulating CD4(+)CD28(null) T cells...
  70. ncbi Control of intestinal inflammation by regulatory T cells
    B Singh
    Sir William Dunn School of Pathology, University of Oxford, Oxford, UK
    Immunol Rev 182:190-200. 2001
    ....
  71. ncbi Requirement for CD4 T cell help in generating functional CD8 T cell memory
    Devon J Shedlock
    Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Science 300:337-9. 2003
    ..These results demonstrate a previously undescribed role for CD4 help in the development of functional CD8 memory...
  72. ncbi Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells
    Thomas Duhen
    Institute for Research in Biomedicine, Bellinzona, Switzerland
    Nat Immunol 10:857-63. 2009
    ..Our findings delineate a previously unknown subset of human CD4(+) effector T cells dedicated to skin pathophysiology...
  73. ncbi Tumor recognition following Vgamma9Vdelta2 T cell receptor interactions with a surface F1-ATPase-related structure and apolipoprotein A-I
    Emmanuel Scotet
    INSERM U601, Institut de Biologie, 9 quai Moncousu, F 44035 Nantes Cedex 01, France
    Immunity 22:71-80. 2005
    ..This study thus describes an unanticipated tumor recognition mechanism by Vgamma9Vdelta2 lymphocytes and a possible link between gammadelta T cell immunity and lipid metabolism...
  74. ncbi Homeostasis of peripheral CD4+ T cells: IL-2R alpha and IL-2 shape a population of regulatory cells that controls CD4+ T cell numbers
    Afonso R M Almeida
    Lymphocyte Population Biology, Unité de Recherche Associée Centre National de la Recherche Scientifique 1961, Institut Pasteur, Paris, France
    J Immunol 169:4850-60. 2002
    ....
  75. pmc CCL25 mediates the localization of recently activated CD8alphabeta(+) lymphocytes to the small-intestinal mucosa
    Marcus Svensson
    Immunology Section, Department of Cell and Molecular Biology, Lund University, Lund, Sweden
    J Clin Invest 110:1113-21. 2002
    ....
  76. ncbi Human gamma delta T cells recognize alkylamines derived from microbes, edible plants, and tea: implications for innate immunity
    J F Bukowski
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Immunity 11:57-65. 1999
    ....
  77. ncbi Stepwise differentiation of CD4 memory T cells defined by expression of CCR7 and CD27
    Ruth D Fritsch
    Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases NIAMS, Bethesda, MD 20892, USA
    J Immunol 175:6489-97. 2005
    ..IL-4 secretion was predominantly conducted by CCR7-CD27- memory CD4 T cells. Thus, by using both CCR7 and CD27, distinct maturational stages of CD4 memory T cells with different functional activities were defined...
  78. ncbi Nonpeptide antigens, presentation mechanisms, and immunological memory of human Vgamma2Vdelta2 T cells: discriminating friend from foe through the recognition of prenyl pyrophosphate antigens
    Craig T Morita
    Division of Rheumatology, Department of Internal Medicine, Interdisciplinary Graduate Program in Immunology, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    Immunol Rev 215:59-76. 2007
    ..Thus, primary infections with HMBPP-producing bacteria are perceived by Vgamma2Vdelta2 T cells as a repeat infection. Extensive efforts are underway to harness these cells to treat a variety of cancers and to provide microbial immunity...
  79. ncbi Activation-induced FOXP3 in human T effector cells does not suppress proliferation or cytokine production
    Sarah E Allan
    Department of Surgery, University of British Columbia, and Immunity and Infection Research Centre, Vancouver Coastal Health Research Institute, 2660 Oak Street, Vancouver, Canada
    Int Immunol 19:345-54. 2007
    ..These data indicate that our current understanding of how FOXP3 contributes to immune tolerance in humans needs to be re-evaluated...
  80. ncbi Mice lacking MHC class II molecules
    D Cosgrove
    Laboratoire de Genetique Moleculaire des Eucaryotes du CNRS, Unité 184 de Biologie Moléculaire de Génie Génétique de l INSERM, Faculte de Medecine, Strasbourg, France
    Cell 66:1051-66. 1991
    ..In short, the class II-negative mice have confirmed some old ideas about lymphocyte differentiation, but have provided some surprises...
  81. ncbi Mechanism of CD1d-restricted natural killer T cell activation during microbial infection
    Manfred Brigl
    Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Immunol 4:1230-7. 2003
    ..We propose this mechanism of activation as a major pathway responsible for the rapid activation of NKT cells in different microbial infections...
  82. ncbi Modulation of tryptophan catabolism by regulatory T cells
    Francesca Fallarino
    Department of Experimental Medicine, University of Perugia, 06126 Perugia, Italy
    Nat Immunol 4:1206-12. 2003
    ..Thus, regulation of immunosuppressive tryptophan catabolism in dendritic cells might represent a major mechanism of action of T(R) cells...
  83. ncbi A role for skin gammadelta T cells in wound repair
    Julie Jameson
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Science 296:747-9. 2002
    ..We propose that DETCs recognize antigen expressed by injured keratinocytes and produce factors that directly affect wound repair...
  84. ncbi IL-21 influences the frequency, phenotype, and affinity of the antigen-specific CD8 T cell response
    Yongqing Li
    Program in Immunology, Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    J Immunol 175:2261-9. 2005
    ....
  85. ncbi TGF-beta 1 plays an important role in the mechanism of CD4+CD25+ regulatory T cell activity in both humans and mice
    Kazuhiko Nakamura
    Mucosal Immunity Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 10, Room 11N238, 10 Center Drive, Bethesda, MD 20892, USA
    J Immunol 172:834-42. 2004
    ..Together, these studies demonstrate that TGF-beta1 produced by CD4+CD25+ T cells is involved in the suppressor activity of these cells, particularly in their ability to regulate intestinal inflammation...
  86. pmc Shared reactivity of V{delta}2(neg) {gamma}{delta} T cells against cytomegalovirus-infected cells and tumor intestinal epithelial cells
    Franck Halary
    UMR 5164, Centre National de la Recherche Scientifique, IFR 66, Universite Bordeaux 2, 33076 Bordeaux, France
    J Exp Med 201:1567-78. 2005
    ....
  87. ncbi Development of human lymphoid cells
    Bianca Blom
    Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Amsterdam 1105 AZ, The Netherlands
    Annu Rev Immunol 24:287-320. 2006
    ....
  88. ncbi IL-1beta and IL-2 convert human Treg into T(H)17 cells
    Florence Deknuydt
    Institut National de la Sante et de la Recherche Medicale, Unite 892, CLCC Rene Gauducheau, Saint Herblain, France
    Clin Immunol 131:298-307. 2009
    ..Our results indicate that, under inflammatory conditions, in the presence of IL-2, Treg can be converted into pro-inflammatory T(H)17 cells and establish a functional link between inflammation and autoimmunity...
  89. pmc Subspecialization of CXCR5+ T cells: B helper activity is focused in a germinal center-localized subset of CXCR5+ T cells
    C H Kim
    Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
    J Exp Med 193:1373-81. 2001
    ..Our results demonstrate that CXCR5+ T cells are functionally heterogeneous and that the GC-Th cells, a small subset of CXCR5+ T cells, are the key helpers for B cell differentiation and antibody production in lymphoid tissues...
  90. ncbi Unique subpopulations of CD56+ NK and NK-T peripheral blood lymphocytes identified by chemokine receptor expression repertoire
    J J Campbell
    Joint Program in Transfusion Medicine, Children s Hospital, 300 Longwood Avenue, Room BD 401, Boston, MA 02115
    J Immunol 166:6477-82. 2001
    ..These findings describe a diverse population of cells that may have trafficking patterns entirely different from each other, and from other lymphocyte types...
  91. ncbi NKT cells derive from double-positive thymocytes that are positively selected by CD1d
    L Gapin
    La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA
    Nat Immunol 2:971-8. 2001
    ..They also show that the early developmental stages of these T cells are not governed by a distinct mechanism, which is consistent with the TCR-instructive model of differentiation...
  92. pmc Implication of gammadelta T cells in the human immune response to cytomegalovirus
    J Dechanet
    Centre National de la Recherche Scientifique UMR 5540, Universite Bordeaux 2, FR60, 33076 Bordeaux, France
    J Clin Invest 103:1437-49. 1999
    ..This in vitro expansion was inhibited by anti-gammadelta TCR mAb's. These findings suggest that a population of gammadelta T cells might play an important role in the immune response of immunosuppressed patients to CMV infection...
  93. pmc IL-22-producing "T22" T cells account for upregulated IL-22 in atopic dermatitis despite reduced IL-17-producing TH17 T cells
    Kristine E Nograles
    Laboratory for Investigative Dermatology, The Rockefeller University, New York, NY 10065, USA
    J Allergy Clin Immunol 123:1244-52.e2. 2009
    ..An upregulated TH17/IL-23 pathway was demonstrated in psoriasis. Although potential involvement of TH17 T cells in AD was suggested during acute disease, the role of these cells in chronic AD remains unclear...
  94. ncbi CD4(+)CD25(+)FoxP3(+) regulatory T cells suppress Mycobacterium tuberculosis immunity in patients with active disease
    Xinchun Chen
    Shenzhen Donghu Hospital, 2019, Buxin Road, Shenzhen 518020, China
    Clin Immunol 123:50-9. 2007
    ..Therefore, CD4(+)CD25(+)FoxP3(+) Treg expanded in TB patients suppress M. tuberculosis immunity and may therefore contribute to the pathogenesis of human TB...
  95. ncbi Immunosuppressive networks in the tumour environment and their therapeutic relevance
    Weiping Zou
    Tulane University Health Sciences Center, Section of Hematology and Medical Oncology, 1430 Tulane Avenue, New Orleans, Louisiana 70112 2699, USA
    Nat Rev Cancer 5:263-74. 2005
    ..Why then has tumour immunotherapy resulted in a generally poor clinical efficiency? The reason might lie in the increasingly documented fact that tumours develop diverse strategies that escape tumour-specific immunity...
  96. pmc Heterogeneity and cell-fate decisions in effector and memory CD8+ T cell differentiation during viral infection
    Susan M Kaech
    Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06437, USA
    Immunity 27:393-405. 2007
    ..Here we discuss recent findings that might help redefine how heterogeneity in antiviral T cell populations gives rise to T cell subsets with short- and long-lived cell fates...
  97. ncbi CD4+CD25high regulatory cells in human peripheral blood
    C Baecher-Allan
    Laboratory of Molecular Immunology, Center for Neurologic Diseases, Brigham and Women s Hospital, Boston, MA 02115
    J Immunol 167:1245-53. 2001
    ....
  98. ncbi Prostaglandin E2 enhances Th17 responses via modulation of IL-17 and IFN-gamma production by memory CD4+ T cells
    Giorgio Napolitani
    Institute for Research in Biomedicine, Bellinzona, Switzerland
    Eur J Immunol 39:1301-12. 2009
    ....
  99. ncbi CD25 is a marker for CD4+ thymocytes that prevent autoimmune diabetes in rats, but peripheral T cells with this function are found in both CD25+ and CD25- subpopulations
    L A Stephens
    Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom
    J Immunol 165:3105-10. 2000
    ..Phenotypic analysis of human thymocytes showed the presence of CD25+ cells in the same proportions as in rat thymus. The possible developmental relationship between CD25+ and CD25- regulatory T cells is discussed...
  100. ncbi The NOD mouse: a model of immune dysregulation
    Mark S Anderson
    Diabetes Center, University of California, San Francisco, California 94143, USA
    Annu Rev Immunol 23:447-85. 2005
    ..The information gained from this highly relevant model of human disease will lead to potential therapies that may alter the development of the disease and its progression in patients with T1D...
  101. pmc Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis
    Vissia Viglietta
    Laboratory of Molecular Immunology, Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 199:971-9. 2004
    ..These data are the first to demonstrate alterations of CD4+CD25hi regulatory T cell function in patients with MS...

Research Grants62

  1. EPICARDIAL ADIPOSE TISSUE, OBESITY AND INFLAMMATION IN ATHEROSCLEROSIS
    Devendra K Agrawal; Fiscal Year: 2013
    ..The proposed studies will provide conceptual support of our hypothesis and position us to translate our investigation into a clinical study in obese patients with coronary artery disease. ..
  2. HIV-induced immune activation impairs immune reconstitution through S1P
    Christel H Uittenbogaart; Fiscal Year: 2013
    ..2. To determine whether HIV infection affects egress of nave T lymphocyte subsets from the thymus to the periphery through changes in S1P receptor expression...
  3. Immune correlates of steroid responsiveness in ITP
    ELINE TJETSKE LUNING PRAK; Fiscal Year: 2010
    ..determine if dexamethasone yields a different response from prednisone in B and T lymphocyte subsets over time;2...
  4. Regulation and Function of Polarity and Asymmetric Cell Division in Immunity
    John T Chang; Fiscal Year: 2013
    ..immunology to test the hypothesis that cell polarity regulates (1) the generation of effector and memory T lymphocyte subsets from their naive predecessors as well as (2) the execution of effector T lymphocyte function...
  5. OPIATE MODULATION OF PULMONARY INFECTION
    Thomas Molitor; Fiscal Year: 2000
    ..bovis activity of T lymphocyte subsets obtained from BCG-immunized swine; and (4) determine the effect of morphine in BCG-immunized swine on ..
  6. PATHOGENESIS OF FELINE LEUKEMIA VIRUS INDUCED AIDS
    Edward Hoover; Fiscal Year: 1993
    ..monoclonal antibodies will be employed to segregate the feline homologues of the human CD4, CD8, and pan T lymphocyte subsets for in vitro studies of viral susceptibility and cytopathicity, to identify the feline lymphocyte subsets ..
  7. Chemokine Signaling and Colitis in Gia2 Deficient Mice
    Robert Edwards; Fiscal Year: 2006
    ..This application has the support of outstanding mentors at two institutions, and funding of this application will foster Dr Edwards' continued development as a physician-scientist. ..
  8. T LYMPHOCYTE-WOUND INTERACTIONS IN TRAUMA
    Adrian Barbul; Fiscal Year: 1991
    ..different times post-wounding and determining the subsets present; c) studying the effect of purified wound T lymphocyte subsets harvested at various times post-wounding on in vitro fibroblast activity (replication, chemotaxis, collagen ..
  9. T LYMPHOCYTE SUBSETS AND HOST DEFENSE AGAINST P CARINII
    JUDD SHELLITO; Fiscal Year: 2001
    ..carinii infection are unknown. This application proposes to investigate the role of T lymphocyte subsets (Th1/Th2) in host responses to this infection. Preliminary data show that clearance of P...
  10. SUPPRESSION OF HEMOPOIESIS BY A NOVEL LYMPHOKINE
    David Tweardy; Fiscal Year: 1990
    ..The ability of their T-lymphocytes and T-lymphocyte subsets to produce CIL and CIL mRNA will be determined...
  11. TRANSPLANT IMMUNOLOGY OF IL2 IFNY DOUBLE KNOCKOUT MICE
    Martin Zand; Fiscal Year: 2002
    ..In contrast, if the DKO mice are tolerant to islet allografts, we will determine the mechanism by adoptive transfer of tolerance inducing T lymphocyte subsets.
  12. COSTIMULATION IN PERIPHERAL T CELL TOLERANCE AND ANERGY
    Jeffrey Bluestone; Fiscal Year: 2000
    ..between receptor-mediated signal transduction pathways that regulate the functions of different T lymphocyte subsets. The Pis will further characterize the signaling block in anergic T cells to produce IL-2...
  13. LYMPHOCYTE ENDOTHELIAL INTERACTIONS IN REJECTION
    Charles Orosz; Fiscal Year: 1993
    ..if regionalized lymphocyte-endothelial interactions are responsible for this anatomic segregation of T lymphocyte subsets. 4) determine if selected immunosuppressive drugs which interfere with T cell accumulation at a graft site ..
  14. INTRACELLULAR CALCIUM REGULATION IN ALZHEIMER'S DISEASE
    ANGELIKA GROSSMAN; Fiscal Year: 1991
    ....
  15. REGULATION OF GRANULOMA IN TUBERCULOSIS
    Padmini Salgame; Fiscal Year: 2001
    ....
  16. MECHANISMS OF SURGICAL ADJUVANT INTRAVESICAL BCG
    Timothy Ratliff; Fiscal Year: 1991
    ..Adoptive transfer of T lymphocyte subsets will be performed to identify the population required for antitumor activity...
  17. Functional Genomics of Inflammation
    JACK HAWIGER; Fiscal Year: 2006
    ..iv) to determine the function of novel genes in development and signaling of phagocytic and mast cells, T lymphocyte subsets, and B lymphocytes...
  18. POST TRANSPLANT T CELL RECONSTITUTION IN NEUROBLASTOMA
    Stephan Grupp; Fiscal Year: 2005
    ..cell reconstitution for patients undergoing SCR and T cell augmentation by measuring: (i) peripheral blood T lymphocyte subsets via flow cytometry, (ii) CD4+ T lymphocyte receptor repertoire via spectratyping, (iii) clinical DTH ..
  19. Neuro-Immune Interactions in Developing Airways
    Gary Larsen; Fiscal Year: 2005
    ..These studies of developmental airway biology in mammalian species allow definition of neuro-immune mechanisms that may have relevance to events that occur in infants and small children. ..
  20. IMMUNOLOGICAL CONTROLS IN HSV LATENCY AND REACTIVATION
    Stephen Jennings; Fiscal Year: 1990
    ..This will be studied by the adoptive transfer of phenotypically and functionally defined HSV-specific T lymphocyte subsets to naive recipients, and by selective in vivo depletion of these subsets by treatment with monoclonal ..
  21. NEUROPSYCHOLOGICAL ASPECTS OF STAGE II/III HIV INFECTION
    HUGH HANDSFIELD; Fiscal Year: 1991
    ..psychometric) testing, culture of peripheral blood lymphocytes for HIV, and monitoring of T lymphocyte subsets. The neuropsychological tests will include measurements of intelligence, attention, concentration, long- ..
  22. MUCOSAL IMMUNITY IN THE FEMALE GENITAL TRACT
    Margaret Parr; Fiscal Year: 1999
    ..to demonstrate that T lymphocytes play a role in immunity to vaginal infection using in vivo depletion of T lymphocyte subsets. Aim 7 is to measure the concentrations of interferons and tumor necrosis factor-alpha in vaginal mucus and ..
  23. TNF-Induced Apoptosis of Lymphocytes in Aged Humans
    Sudhir Gupta; Fiscal Year: 2004
    ..These studied should mechanism (s) for increased TNF-a-induced apoptosis during aging. ..
  24. Antigen Presentation Pathway by CD1 Molecules
    Mitchell Kronenberg; Fiscal Year: 2006
    ..The results from these studies will aid in our understanding of lipid antigen presentation, and they should help in the design of lipid antigen-based vaccines and in attempts to alter immune regulation by stimulating NK T cells. ..
  25. Impact of chronic infection in the aged on the response to vaccination
    Andrea Cooper; Fiscal Year: 2007
    ..These experiments are relevant to human health since determining the effect of inflammation on the response to vaccination will allow us to improve vaccination in the elderly. [unreadable] [unreadable] [unreadable] [unreadable]..
  26. 2007 Immunobiology and Immunochemistry Gordon Research Conference
    Mitchell Kronenberg; Fiscal Year: 2007
    ..Participation by women and under represented minorities[unreadable] is actively sought. In this application, we seek support for this important and prestigious[unreadable] conference. ..
  27. NKT Cell Recognition of Streptococcus Pneumoniae
    Mitchell Kronenberg; Fiscal Year: 2008
    ..pneumoniae, which could lead to the development of more effective vaccines against this organism. [unreadable] [unreadable] [unreadable] [unreadable]..
  28. Immunochemistry & Immunobiology 2008 Gordon Research Conference
    Mitchell Kronenberg; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  29. Recognition of bacterial antigens by NKT cells
    Mitchell Kronenberg; Fiscal Year: 2010
    ..abstract_text> ..
  30. The role of IL-12p40 in the response of pulmonary dendritic cells to tuberculosis
    Andrea M Cooper; Fiscal Year: 2010
    ..This increased understanding will allow targeted and novel interventions that will improve our ability to control disease. ..
  31. ANTIGEN PRESENTATION AND IMMUNE REGULATION BY CD1
    Mitchell Kronenberg; Fiscal Year: 2004
    ..Suck knowledge could lead to novel immune therapies for cancer and autoimmune disease. ..
  32. IMMUNOPATHOGENESIS OF MYCOBACTERIUM AVIUM DISEASE
    Andrea Cooper; Fiscal Year: 2001
    ..Finally, they will test the hypothesis that appropriate chemotherapy can restore the correct immunologic functions/signals, using both established regimens, as well as new compounds recently identified in their laboratory as active. ..
  33. Role of Notch 1 in Immune Tolerance
    Jeffrey Bluestone; Fiscal Year: 2005
    ..To Identify the biochemical, cellular and genetic effects of Notch signaling in T cells; and Specific Aim #2. In vivo application of Notch signaling for the establishment of peripheral T cell tolerance. ..
  34. Airway Function-Role of gamma/delta T Cells
    Willi Born; Fiscal Year: 2007
    ..We will examine the significance of these requirements with regard to ligand recognition and activation of the gammadelta T cells, and with regard to their interaction with DC. ..
  35. GENE SILENCING IN THE IMMUNE RESPONSE TO PARASITES
    STEVEN REINER; Fiscal Year: 2007
    ..Successful execution of the 3 specific aims of this proposal should provide novel insight into the way that helper T cells mature, and novel strategies to defend humans against parasitic invaders. ..
  36. GAMMA DELTA T CELL RESPONSES TO POLYVALENT ANTIGENS
    Willi Born; Fiscal Year: 2004
    ..4. To establish the phospholipid cardiolipin as an antigen for innate gamma/delta T-cell responses, and to investigate the role of gamma/delta T-cells in the development of pathogenic anti-phospholipid antibodies. ..
  37. IMMUNOLOGIC POLYMORPHISM IN EXPERIMENTAL LYME ARTHRITIS
    STEVEN REINER; Fiscal Year: 2001
    ....
  38. Conf on Mechanism and Applications of Immune Tolerance
    Jeffrey Bluestone; Fiscal Year: 2002
    ..Finally, specific talks in immunotherapy of autoimmunity, transplantation, cancer and infectious disease will be included. ..
  39. Minor H Antigen Regulatory Networks as an Alternative to Calcineurin Inhibitors i
    WILLIAM BURLINGHAM; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  40. CD8 T Cell Response to Influenza Virus Infection
    Leo Lefrancois; Fiscal Year: 2008
    ..Overall, these studies will fill a significant gap in our knowledge regarding the role of memory CD8 T cells in controlling influenza virus infection. [unreadable] [unreadable] [unreadable]..
  41. KIDNEY TRANSPLANTATION & NON-INHERITED MATERNAL ANTIGENS
    WILLIAM BURLINGHAM; Fiscal Year: 2003
    ..Our goal is to establish the basis for a rational approach to HLA-matching and selective NIMA mismatching to achieve the goal of clinical kidney transplantation tolerance. ..
  42. Signal Transduction and Cytokine Gene Regulation by Grail
    Chen Dong; Fiscal Year: 2008
    ..These proposed studies will greatly advance our knowledge on Grail function in T cells and give an important insight into T cell signal transduction and gene regulation programs in immune responses. ..
  43. CD4+ T CELLS PROMOTE EARLY ATHEROSCLEROSIS
    Sally Huber; Fiscal Year: 2002
    ..Specific Aim 3 will investigate the role of CD4+ T cells in atherogenesis and evaluate whether these cells promote Th1 cell dominance. ..
  44. CELL MEDIATED IMMUNITY TO SENDAI VIRUS
    DAVID WOODLAND; Fiscal Year: 2001
    ....
  45. Memory T cell subsets and pulmonary immunity
    David L Woodland; Fiscal Year: 2010
    ....
  46. T reg Cells in Myocarditis
    Sally A Huber; Fiscal Year: 2010
    ..Determine whether the T reg cells are antigen specific (virus), cardiovascular specific (autoimmunity), or non-antigen specific. ..
  47. Post-Thymic T-Cell Functional Heterogeneity
    Casey T Weaver; Fiscal Year: 2010
    ..We anticipate that successful completion of these studies will provide an understanding of CD4 T lineage effector and memory cell development that will suggest improved strategies for vaccine development and immunotherapy...
  48. Regulation and mechanism of agonist selection
    Hilde Cheroutre; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  49. INTESTINE AS A SITE OF EXTRATHYMIC T CELL GENERATION
    Leo Lefrancois; Fiscal Year: 2003
    ..Overall, these studies will provide basic answers to how T call development occurs in general and provide insight into the development and function of the mucosal immune system. ..
  50. CDI and Gamma Delta+ in Viral Myocarditis
    Sally Huber; Fiscal Year: 2005
    ..abstract_text> ..
  51. CD4+T cell immunity to respiratory virus infections
    DAVID WOODLAND; Fiscal Year: 2004
    ....
  52. FASEB Research Conference: Lymphocytes and Antibodies
    Leo Lefrancois; Fiscal Year: 2004
    ..In Vivo T Cell Activation - Marc Jenkins (UMINN), Session Organizer 9. Cytokine Control of Immunity - Leo Lefrancois (UCHC), Session Organizer ..
  53. Sex in Viral Myocarditis
    Sally Huber; Fiscal Year: 2004
    ..These studies may provide new insights as to how viruses affect developing host defense responses and how hormones can modulate this initial response. ..
  54. Leptin-based intervention in systemic autoimmunity
    Antonio La Cava; Fiscal Year: 2006
    ..abstract_text> ..
  55. Advances in Influenza Research - From Birds to Bench to Bedside
    DAVID WOODLAND; Fiscal Year: 2006
    ..The goal of this meeting is to bring together virologists, immunologists and vaccine researchers to discuss recent advances in influenza research and to develop better measures to prevent and control influenza. ..
  56. REGULATION OF MUCOSAL MEMORY T CELL INDUCTION
    Leo Lefrancois; Fiscal Year: 2006
    ..Overall, these studies will provide significant new information regarding the population dynamics of T cell memory generation and migration in vivo in response to infection. ..
  57. Large Scale Images of Gene Transcription in MS and EAE
    Lawrence Steinman; Fiscal Year: 2004
    ..The discovery of the role of osteopontin, first identified in large scale profiles, exemplifies how this approach may help us to understand MS and to develop new therapies. ..
  58. IMMUNE REGULATION IN LUNG TRANSPLANTATION
    WILLIAM BURLINGHAM; Fiscal Year: 2003
    ..We will determine how the sensitivity, specificity, and predictive value of each test would be clinically useful in the management of lung transplant patients. ..
  59. PEPTIDE MEDIATED IMMUNOTHERAPY FOR AUTOIMMUNE DISEASE
    Lawrence Steinman; Fiscal Year: 2003
    ..This work with APL may be applicable not only to MS, but to other autoimmune diseases including juvenile diabetes, rheumatoid arthritis, and inflammatory bowel disease. ..
  60. Sex in Myocarditis
    Sally Huber; Fiscal Year: 2008
    ..By understanding the factors controlling virus infection and induction of innate immunity, better mechanism for controlling viral disease should be possible. ..
  61. Genetics of Longevity and Age-Sensitive Traits in Mice
    Richard Miller; Fiscal Year: 2008
    ..abstract_text> ..