t lymphocyte subsets

Summary

Summary: A classification of T-lymphocytes, especially into helper/inducer, suppressor/effector, and cytotoxic subsets, based on structurally or functionally different populations of cells.

Top Publications

  1. ncbi Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
    F Sallusto
    Basel Institute for Immunology, Switzerland
    Nature 401:708-12. 1999
  2. ncbi Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
    S Sakaguchi
    Precursory Research for Embryonic Science and Technology PRESTO, Research and Development Corporation of Japan JRDC, Tsukuba Life Science Center
    J Immunol 155:1151-64. 1995
  3. ncbi Central memory and effector memory T cell subsets: function, generation, and maintenance
    Federica Sallusto
    Institute for Research in Biomedicine, CH 6500 Bellinzona, Switzerland
    Annu Rev Immunol 22:745-63. 2004
  4. ncbi Control of regulatory T cell development by the transcription factor Foxp3
    Shohei Hori
    Laboratory of Immunopathology, Research Center for Allergy and Immunology, Institute for Physical and Chemical Research, Yokohama 230 0045, Japan
    Science 299:1057-61. 2003
  5. ncbi Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells
    Susan M Kaech
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, 1510 Clifton Road, Atlanta, Georgia 30322, USA
    Nat Immunol 4:1191-8. 2003
  6. pmc T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma
    Xuexian O Yang
    Department of Immunology, M D Anderson Cancer Center, Houston, TX 77030, USA
    Immunity 28:29-39. 2008
  7. ncbi Development, cytokine profile and function of human interleukin 17-producing helper T cells
    Nicholas J Wilson
    Department of Discovery Research, Schering Plough Biopharma Formerly DNAX Research, Palo Alto, California 94304 1104, USA
    Nat Immunol 8:950-7. 2007
  8. pmc Late developmental plasticity in the T helper 17 lineage
    Yun Kyung Lee
    Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Immunity 30:92-107. 2009
  9. ncbi Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance
    Jun Shimizu
    Department of Immunopathology, Tokyo Metropolitan Institute of Gerontology, Tokyo 173 0015, Japan
    Nat Immunol 3:135-42. 2002
  10. ncbi Transforming growth factor-beta regulation of immune responses
    Ming O Li
    Section of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Annu Rev Immunol 24:99-146. 2006

Research Grants

  1. ANALYSIS OF SPOTTED FEVER RICKETTSIAL ANTIGENS
    David Walker; Fiscal Year: 1993
  2. ANALYSIS OF SPOTTED FEVER RICKETTSIAL ANTIGENS
    David Walker; Fiscal Year: 1992
  3. HUMAN T LYMPHOCYTE FUNCTION IN LUPUS ERYTHEMATOSUS
    Gary Kammer; Fiscal Year: 1990
  4. OPIATE MODULATION OF PULMONARY INFECTION
    Thomas Molitor; Fiscal Year: 1999
  5. OPIATE MODULATION OF PULMONARY INFECTION
    Thomas Molitor; Fiscal Year: 2000
  6. T CELL FUNCTION IN ANTIVIRAL IMMUNITY
    Mary Graham; Fiscal Year: 1991
  7. PATHOGENESIS OF FELINE LEUKEMIA VIRUS INDUCED AIDS
    Edward Hoover; Fiscal Year: 1990
  8. Chemokine Signaling and Colitis in Gia2 Deficient Mice
    Robert Edwards; Fiscal Year: 2002
  9. Chemokine Signaling and Colitis in Gia2 Deficient Mice
    Robert Edwards; Fiscal Year: 2003
  10. Chemokine Signaling and Colitis in Gia2 Deficient Mice
    Robert Edwards; Fiscal Year: 2005

Detail Information

Publications312 found, 100 shown here

  1. ncbi Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
    F Sallusto
    Basel Institute for Immunology, Switzerland
    Nature 401:708-12. 1999
    ....
  2. ncbi Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
    S Sakaguchi
    Precursory Research for Embryonic Science and Technology PRESTO, Research and Development Corporation of Japan JRDC, Tsukuba Life Science Center
    J Immunol 155:1151-64. 1995
    ..Abnormality of this T cell-mediated mechanism of peripheral tolerance can be a possible cause of various autoimmune diseases...
  3. ncbi Central memory and effector memory T cell subsets: function, generation, and maintenance
    Federica Sallusto
    Institute for Research in Biomedicine, CH 6500 Bellinzona, Switzerland
    Annu Rev Immunol 22:745-63. 2004
    ..This review addresses the heterogeneity of TCM and TEM, their differentiation stages, and the current models for their generation and maintenance in humans and mice...
  4. ncbi Control of regulatory T cell development by the transcription factor Foxp3
    Shohei Hori
    Laboratory of Immunopathology, Research Center for Allergy and Immunology, Institute for Physical and Chemical Research, Yokohama 230 0045, Japan
    Science 299:1057-61. 2003
    ..Thus, Foxp3 is a key regulatory gene for the development of regulatory T cells...
  5. ncbi Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells
    Susan M Kaech
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, 1510 Clifton Road, Atlanta, Georgia 30322, USA
    Nat Immunol 4:1191-8. 2003
    ..Thus, selective expression of IL-7R identifies memory cell precursors, and this marker may be useful in predicting the number of memory T cells generated after infection or immunization...
  6. pmc T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma
    Xuexian O Yang
    Department of Immunology, M D Anderson Cancer Center, Houston, TX 77030, USA
    Immunity 28:29-39. 2008
    ..Therefore, Th17 differentiation is directed by two lineage-specific nuclear receptors, ROR alpha and ROR gamma...
  7. ncbi Development, cytokine profile and function of human interleukin 17-producing helper T cells
    Nicholas J Wilson
    Department of Discovery Research, Schering Plough Biopharma Formerly DNAX Research, Palo Alto, California 94304 1104, USA
    Nat Immunol 8:950-7. 2007
    ..Our data collectively indicate that human and mouse T(H)-17 cells require distinct factors during differentiation and that human T(H)-17 cells may regulate innate immunity in epithelial cells...
  8. pmc Late developmental plasticity in the T helper 17 lineage
    Yun Kyung Lee
    Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Immunity 30:92-107. 2009
    ..These results support a model of late Th17 developmental plasticity with implications for autoimmunity and host defense...
  9. ncbi Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance
    Jun Shimizu
    Department of Immunopathology, Tokyo Metropolitan Institute of Gerontology, Tokyo 173 0015, Japan
    Nat Immunol 3:135-42. 2002
    ..Thus, GITR plays a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells and could be a suitable molecular target for preventing or treating autoimmune disease...
  10. ncbi Transforming growth factor-beta regulation of immune responses
    Ming O Li
    Section of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Annu Rev Immunol 24:99-146. 2006
    ..This review highlights the findings that have advanced our understanding of TGF-beta in the immune system and in disease...
  11. ncbi Phenotype and function of human T lymphocyte subsets: consensus and issues
    Victor Appay
    Cellular Immunology Laboratory, INSERM U543, Avenir Group, Hopital Pitie Salpetriere, Universite Pierre et Marie Curie PARIS6, 75013 Paris, France
    Cytometry A 73:975-83. 2008
    ..Finally, we discuss the problems which still limit general agreement...
  12. pmc Identification and functional characterization of human CD4(+)CD25(+) T cells with regulatory properties isolated from peripheral blood
    H Jonuleit
    Department of Dermatology, University of Mainz, D 55101 Mainz, Germany
    J Exp Med 193:1285-94. 2001
    ..However, the refractory state of CD4(+)CD25(+) T cells was partially reversible by the addition of IL-2 or IL-4. These data demonstrate that human blood contains a resident T cell population with potent regulatory properties...
  13. doi Transforming growth factor-beta 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9-producing subset
    Marc Veldhoen
    Division of Molecular Immunology, Medical Research Council National Institute for Medical Research, London NW7 1AA, UK
    Nat Immunol 9:1341-6. 2008
    ..Thus, transforming growth factor-beta constitutes a regulatory 'switch' that in combination with other cytokines can 'reprogram' effector T cell differentiation along different pathways...
  14. pmc Global mapping of H3K4me3 and H3K27me3 reveals specificity and plasticity in lineage fate determination of differentiating CD4+ T cells
    Gang Wei
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 30:155-67. 2009
    ..Our data suggest an epigenetic mechanism underlying the specificity and plasticity of effector and regulatory T cells and also provide a framework for understanding complexity of CD4(+) T helper cell differentiation...
  15. ncbi Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells
    Eva V Acosta-Rodriguez
    Institute for Research in Biomedicine, CH 6500 Bellinzona, Switzerland
    Nat Immunol 8:942-9. 2007
    ....
  16. pmc The biological functions of T helper 17 cell effector cytokines in inflammation
    Wenjun Ouyang
    Department of Immunology, Genentech, 1 DNA Way, South San Francisco, California 94080, USA
    Immunity 28:454-67. 2008
    ..The effector cytokines of Th17 cells, therefore, mediate the crucial crosstalk between immune system and tissues, and play indispensable roles in tissue immunity...
  17. ncbi IL-17 production is dominated by gammadelta T cells rather than CD4 T cells during Mycobacterium tuberculosis infection
    Euan Lockhart
    Department of Molecular Genetics and Biochemistry, Biomedical Science Tower, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    J Immunol 177:4662-9. 2006
    ..tuberculosis-infected dendritic cells. IL-23 is present in the lungs early in infection and the IL-17-producing cells, such as gammadelta T cells, may represent a central innate protective response to pulmonary infection...
  18. pmc IL-4 inhibits TGF-beta-induced Foxp3+ T cells and, together with TGF-beta, generates IL-9+ IL-10+ Foxp3(-) effector T cells
    Valerie Dardalhon
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Cambridge, Massachusetts 02139, USA
    Nat Immunol 9:1347-55. 2008
    ..Thus IL-9(+)IL-10(+) T cells lack suppressive function and constitute a distinct population of helper-effector T cells that promote tissue inflammation...
  19. ncbi Regulatory T cell lineage specification by the forkhead transcription factor foxp3
    Jason D Fontenot
    Department of Immunology, University of Washington, Seattle, Washington 98195, USA
    Immunity 22:329-41. 2005
    ..Analysis of Foxp3 expression during thymic development suggests that this mechanism is not hard-wired but is dependent on TCR/MHC ligand interactions...
  20. ncbi Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid
    Daniel Mucida
    La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA
    Science 317:256-60. 2007
    ..These findings indicate that a common metabolite can regulate the balance between pro- and anti-inflammatory immunity...
  21. pmc Th17 cells promote pancreatic inflammation but only induce diabetes efficiently in lymphopenic hosts after conversion into Th1 cells
    Natalia Martin-Orozco
    Department of Immunology, MD Anderson Cancer Center, Houston, TX 77030, USA
    Eur J Immunol 39:216-24. 2009
    ..These results indicate that islet-reactive Th17 cells promote pancreatic inflammation, but only induce IDDM upon conversion into IFN-gamma producers...
  22. ncbi IL-25 induces IL-4, IL-5, and IL-13 and Th2-associated pathologies in vivo
    M M Fort
    DNAX Research Institute, Palo Alto, CA 94304, USA
    Immunity 15:985-95. 2001
    ..These results suggest that IL-25, derived from Th2 T cells, is capable of amplifying allergic type inflammatory responses by its actions on other cell types...
  23. pmc Molecular antagonism and plasticity of regulatory and inflammatory T cell programs
    Xuexian O Yang
    Department of Immunology, M D Anderson Cancer Center, Houston, TX 77030, USA
    Immunity 29:44-56. 2008
    ..STAT3 regulated Foxp3 downregulation, whereas STAT3, RORgamma, and ROR* were required for IL-17 expression in Treg cells. Our data demonstrate molecular antagonism and plasticity of Treg and Th17 cell programs...
  24. ncbi NKT cells: facts, functions and fallacies
    D I Godfrey
    Dept of Pathology and Immunology, Monash University Medical School, Commercial Road, VIC 3181, Prahran, Australia
    Immunol Today 21:573-83. 2000
    ..Heterogeneity of these cells contributes to the controversy surrounding their development and function. This review aims to provide an update on NKT cell biology and, whenever possible, to compare what is known about NKT-cell subsets...
  25. pmc IL-9 as a mediator of Th17-driven inflammatory disease
    Elizabeth C Nowak
    Department of Microbiology and Immunology, Dartmouth Medical School and the Norris Cotton Cancer Center, Lebanon, NH 03756, USA
    J Exp Med 206:1653-60. 2009
    ..Collectively, these data implicate IL-9 as a Th17-derived cytokine that can contribute to inflammatory disease...
  26. ncbi The VITAL assay: a versatile fluorometric technique for assessing CTL- and NKT-mediated cytotoxicity against multiple targets in vitro and in vivo
    Ian F Hermans
    Tumour Immunology Unit, Nuffield Department of Medicine, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK
    J Immunol Methods 285:25-40. 2004
    ..The VITAL assay is, therefore, a sensitive technique allowing analysis of complex multi-epitope responses...
  27. ncbi Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity
    P Bouillet
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia
    Science 286:1735-8. 1999
    ..Thus, Bim is required for hematopoietic homeostasis and as a barrier to autoimmunity. Moreover, particular death stimuli appear to activate apoptosis through distinct BH3-only proteins...
  28. ncbi Inducing and expanding regulatory T cell populations by foreign antigen
    Karsten Kretschmer
    Department of Pathology, Harvard Medical School, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Nat Immunol 6:1219-27. 2005
    ..The extrathymic generation and proliferation of regulatory T cells may contribute to self-tolerance as well as the poor immunogenicity of tumors and may be exploited clinically to prevent or reverse unwanted immunity...
  29. pmc Essential role for CD103 in the T cell-mediated regulation of experimental colitis
    Oliver Annacker
    Sir William Dunn School of Pathology, University of Oxford, OX1 3RE, England, UK
    J Exp Med 202:1051-61. 2005
    ..Collectively, these data suggest that CD103+ and CD103- DCs represent functionally distinct subsets and that CD103 expression on DCs influences the balance between effector and regulatory T cell activity in the intestine...
  30. ncbi CD8 T cell dysfunction during chronic viral infection
    Haina Shin
    Immunology Program, The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA
    Curr Opin Immunol 19:408-15. 2007
    ..In this review, we will discuss recent work that highlights two main types of T cell dysfunction during chronic infection: exhaustion of effector functions and altered memory T cell development...
  31. pmc Th17 cells in human disease
    Laura A Tesmer
    Department of Internal Medicine, Division of Rheumatology, Rheumatic Disease Core Center, University of Michigan, Ann Arbor, MI 48109 5358, USA
    Immunol Rev 223:87-113. 2008
    ....
  32. ncbi Recognition of bacterial glycosphingolipids by natural killer T cells
    Yuki Kinjo
    Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, San Diego, 10355 Science Center Drive, San Diego, California 92121, USA
    Nature 434:520-5. 2005
    ....
  33. ncbi Toward an understanding of NKT cell biology: progress and paradoxes
    Mitchell Kronenberg
    La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    Annu Rev Immunol 23:877-900. 2005
    ..Despite this uncertainty, many investigators are hopeful that immune therapies can be developed based on NKT cell stimulation...
  34. ncbi Exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections
    Jochen Mattner
    Committee on Immunology, University of Chicago, Chicago, Illinois 60637, USA
    Nature 434:525-9. 2005
    ..These findings identify two novel antigenic targets of NKT cells in antimicrobial defence, and show that glycosylceramides are an alternative to LPS for innate recognition of the Gram-negative, LPS-negative bacterial cell wall...
  35. pmc CD4+CD25+ T cells regulate virus-specific primary and memory CD8+ T cell responses
    Susmit Suvas
    Department of Microbiology, University of Tennessee, Knoxville, TN 37996 0845, USA
    J Exp Med 198:889-901. 2003
    ..Thus, controlling suppressor effects at the time of vaccination could result in more effective immunity...
  36. ncbi Homeostasis of peripheral CD4+ T cells: IL-2R alpha and IL-2 shape a population of regulatory cells that controls CD4+ T cell numbers
    Afonso R M Almeida
    Lymphocyte Population Biology, Unité de Recherche Associée Centre National de la Recherche Scientifique 1961, Institut Pasteur, Paris, France
    J Immunol 169:4850-60. 2002
    ....
  37. pmc A crucial role for interleukin (IL)-1 in the induction of IL-17-producing T cells that mediate autoimmune encephalomyelitis
    Caroline Sutton
    Immune Regulation Research Group, School of Biochemistry and Immunology, Trinity College, Dublin 2, Ireland
    J Exp Med 203:1685-91. 2006
    ..Tumor necrosis factor alpha also synergized with IL-23 to enhance IL-17 production, and this was IL-1 dependent. Our findings demonstrate that IL-1 functions upstream of IL-17 to promote pathogenic ThIL-17 cells in EAE...
  38. pmc Expression of the integrin alpha Ebeta 7 identifies unique subsets of CD25+ as well as CD25- regulatory T cells
    Joachim Lehmann
    Experimentelle Rheumatologie, Universitatsklinikum Charite, Humboldt Universitat, c o Deutsches Rheumaforschungszentrum, 10117 Berlin, Germany
    Proc Natl Acad Sci U S A 99:13031-6. 2002
    ..Thus, the integrin alpha(E)beta(7) can be regarded as a novel marker for subsets of highly potent, functionally distinct regulatory T cells specialized for crosstalk with epithelial environments...
  39. pmc Selective expression of IL-7 receptor on memory T cells identifies early CD40L-dependent generation of distinct CD8+ memory T cell subsets
    Katharina M Huster
    Institute for Medical Microbiology, Immunology, and Hygiene, Technical University of Munich, 81675 Munich, Germany
    Proc Natl Acad Sci U S A 101:5610-5. 2004
    ....
  40. ncbi Recognition of stress-induced MHC molecules by intestinal epithelial gammadelta T cells
    V Groh
    Fred Hutchinson Cancer Research Center, Clinical Research Division, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    Science 279:1737-40. 1998
    ..Thus, these molecules may broadly regulate protective responses by the Vdelta1 gammadelta T cells in the epithelium of the intestinal tract...
  41. ncbi Inhibiting Stat3 signaling in the hematopoietic system elicits multicomponent antitumor immunity
    Marcin Kortylewski
    H Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, Florida 33612, USA
    Nat Med 11:1314-21. 2005
    ..Our findings show that Stat3 signaling restrains natural tumor immune surveillance and that inhibiting hematopoietic Stat3 in tumor-bearing hosts elicits multicomponent therapeutic antitumor immunity...
  42. pmc Cutting edge: NKT cells constitutively express IL-23 receptor and RORgammat and rapidly produce IL-17 upon receptor ligation in an IL-6-independent fashion
    Aleksandra V Rachitskaya
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 180:5167-71. 2008
    ..These data suggest an important biological role for innate IL-17 production by NKT cells that is rapid and precedes the adaptive IL-17 response...
  43. pmc Differential tumor surveillance by natural killer (NK) and NKT cells
    M J Smyth
    Cellular Cytotoxicity Laboratory, Austin Research Institute, Austin and Repatriation Medical Centre, Heidelberg, 3084 Victoria, Australia
    J Exp Med 191:661-8. 2000
    ..This is the first description of an antitumor function for NKT cells in the absence of exogenously administered potent stimulators such as IL-12 or alpha-galactosylceramide...
  44. ncbi IFN-alpha and IL-10 induce the differentiation of human type 1 T regulatory cells
    M K Levings
    San Raffaele Telethon Institute for Gene Therapy (HSR-TIGET, Milan, Italy
    J Immunol 166:5530-9. 2001
    ....
  45. ncbi IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways
    Liang Zhou
    The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, New York 10016, USA
    Nat Immunol 8:967-74. 2007
    ..IL-6 therefore orchestrates a series of 'downstream' cytokine-dependent signaling pathways that, in concert with TGF-beta, amplify RORgammat-dependent differentiation of T(H)-17 cells...
  46. ncbi CD25- T cells generate CD25+Foxp3+ regulatory T cells by peripheral expansion
    Maria A Curotto de Lafaille
    Molecular Pathogenesis Program, Skirball Institute, and Department of Pathology, New York University School of Medicine, New York, NY 10016, USA
    J Immunol 173:7259-68. 2004
    ..The maintenance of CD25 expression by CD4(+)CD25(+) cells depends on IL-2 secreted by cotransferred CD4(+)CD25(-) or by Ag-stimulated T cells in peripheral lymphoid organs...
  47. pmc Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells
    Nabila Seddiki
    Centenary Institute of Cancer Medicine and Cell Biology, Faculty of Medicine, University of Sydney, Newtown, NSW 2042, Australia
    J Exp Med 203:1693-700. 2006
    ....
  48. ncbi CD1d-restricted and TCR-mediated activation of valpha14 NKT cells by glycosylceramides
    T Kawano
    CREST Core Research for Evolutional Science and Technology Project, Japan Science and Technology Corporation JST, 1 8 1 Inohana, Chuo, Chiba 260, Japan
    Science 278:1626-9. 1997
    ..Thus, this lymphocyte shares distinct recognition systems with either T or NK cells...
  49. ncbi Preferential localization of effector memory cells in nonlymphoid tissue
    D Masopust
    Division of Immunology, Department of Medicine, University of Connecticut Health Center, Farmington, CT 06030, USA
    Science 291:2413-7. 2001
    ..These results point to the existence of a population of extralymphoid effector memory T cells poised for immediate response to infection...
  50. ncbi Immunology of tuberculosis
    J L Flynn
    Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Annu Rev Immunol 19:93-129. 2001
    ..The pace of this research must be maintained if we are to realize an effective vaccine in the next decades...
  51. ncbi CD1d1 mutant mice are deficient in natural T cells that promptly produce IL-4
    S K Mendiratta
    Howard Hughes Medical Institute, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Immunity 6:469-77. 1997
    ..These results demonstrate a critical role for CD1 in the positive selection and function of NT cells...
  52. ncbi Cutting edge: control of CD8+ T cell activation by CD4+CD25+ immunoregulatory cells
    C A Piccirillo
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
    J Immunol 167:1137-40. 2001
    ....
  53. ncbi Unique subpopulations of CD56+ NK and NK-T peripheral blood lymphocytes identified by chemokine receptor expression repertoire
    J J Campbell
    Joint Program in Transfusion Medicine, Children s Hospital, 300 Longwood Avenue, Room BD 401, Boston, MA 02115
    J Immunol 166:6477-82. 2001
    ..These findings describe a diverse population of cells that may have trafficking patterns entirely different from each other, and from other lymphocyte types...
  54. pmc Major histocompatibility complex class I-recognizing receptors are disease risk genes in rheumatoid arthritis
    J H Yen
    Department of Medicine and the Department of Immunology, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Exp Med 193:1159-67. 2001
    ..Specifically, KIR2DS2 in conjunction with the appropriate HLA-C ligand may have a role in vascular damage by regulating CD4(+)CD28(null) T cells...
  55. ncbi NKT cells: what's in a name?
    Dale I Godfrey
    Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria 3010, Australia
    Nat Rev Immunol 4:231-7. 2004
  56. pmc Rapid acquisition of tissue-specific homing phenotypes by CD4(+) T cells activated in cutaneous or mucosal lymphoid tissues
    Daniel J Campbell
    Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Exp Med 195:135-41. 2002
    ....
  57. ncbi Control of intestinal inflammation by regulatory T cells
    B Singh
    Sir William Dunn School of Pathology, University of Oxford, Oxford, UK
    Immunol Rev 182:190-200. 2001
    ....
  58. ncbi Requirement for CD4 T cell help in generating functional CD8 T cell memory
    Devon J Shedlock
    Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Science 300:337-9. 2003
    ..These results demonstrate a previously undescribed role for CD4 help in the development of functional CD8 memory...
  59. doi Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells
    Thomas Duhen
    Institute for Research in Biomedicine, Bellinzona, Switzerland
    Nat Immunol 10:857-63. 2009
    ..Our findings delineate a previously unknown subset of human CD4(+) effector T cells dedicated to skin pathophysiology...
  60. ncbi Tumor recognition following Vgamma9Vdelta2 T cell receptor interactions with a surface F1-ATPase-related structure and apolipoprotein A-I
    Emmanuel Scotet
    INSERM U601, Institut de Biologie, 9 quai Moncousu, F 44035 Nantes Cedex 01, France
    Immunity 22:71-80. 2005
    ..This study thus describes an unanticipated tumor recognition mechanism by Vgamma9Vdelta2 lymphocytes and a possible link between gammadelta T cell immunity and lipid metabolism...
  61. ncbi Mice lacking MHC class II molecules
    D Cosgrove
    Laboratoire de Genetique Moleculaire des Eucaryotes du CNRS, Unité 184 de Biologie Moléculaire de Génie Génétique de l INSERM, Faculte de Medecine, Strasbourg, France
    Cell 66:1051-66. 1991
    ..In short, the class II-negative mice have confirmed some old ideas about lymphocyte differentiation, but have provided some surprises...
  62. pmc Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction
    Kojiro Sato
    Department of Cell Signaling, Graduate School, and COE Program for Frontier Research on Molecular Destruction and Reconstruction of Tooth and Bone, Tokyo Medical and Dental University, Tokyo 113 8549, Japan
    J Exp Med 203:2673-82. 2006
    ..Thus, Th17 is a powerful therapeutic target for the bone destruction associated with T cell activation...
  63. ncbi Mechanism of CD1d-restricted natural killer T cell activation during microbial infection
    Manfred Brigl
    Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Immunol 4:1230-7. 2003
    ..We propose this mechanism of activation as a major pathway responsible for the rapid activation of NKT cells in different microbial infections...
  64. ncbi Modulation of tryptophan catabolism by regulatory T cells
    Francesca Fallarino
    Department of Experimental Medicine, University of Perugia, 06126 Perugia, Italy
    Nat Immunol 4:1206-12. 2003
    ..Thus, regulation of immunosuppressive tryptophan catabolism in dendritic cells might represent a major mechanism of action of T(R) cells...
  65. pmc Cytokine-driven proliferation and differentiation of human naive, central memory, and effector memory CD4(+) T cells
    J Geginat
    Institute for Research in Biomedicine, Bellinzona 6500, Switzerland
    J Exp Med 194:1711-9. 2001
    ..The sustained antigen-independent generation of T(EM) from a pool of T(CM) cells provides a plausible mechanism for the maintenance of a polyclonal and functionally diverse repertoire of human CD4(+) memory T cells...
  66. ncbi A role for skin gammadelta T cells in wound repair
    Julie Jameson
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Science 296:747-9. 2002
    ..We propose that DETCs recognize antigen expressed by injured keratinocytes and produce factors that directly affect wound repair...
  67. ncbi CD4(+)CD25(+)FoxP3(+) regulatory T cells suppress Mycobacterium tuberculosis immunity in patients with active disease
    Xinchun Chen
    Shenzhen Donghu Hospital, 2019, Buxin Road, Shenzhen 518020, China
    Clin Immunol 123:50-9. 2007
    ..Therefore, CD4(+)CD25(+)FoxP3(+) Treg expanded in TB patients suppress M. tuberculosis immunity and may therefore contribute to the pathogenesis of human TB...
  68. ncbi Immunosuppressive networks in the tumour environment and their therapeutic relevance
    Weiping Zou
    Tulane University Health Sciences Center, Section of Hematology and Medical Oncology, 1430 Tulane Avenue, New Orleans, Louisiana 70112 2699, USA
    Nat Rev Cancer 5:263-74. 2005
    ..Why then has tumour immunotherapy resulted in a generally poor clinical efficiency? The reason might lie in the increasingly documented fact that tumours develop diverse strategies that escape tumour-specific immunity...
  69. pmc Heterogeneity and cell-fate decisions in effector and memory CD8+ T cell differentiation during viral infection
    Susan M Kaech
    Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06437, USA
    Immunity 27:393-405. 2007
    ..Here we discuss recent findings that might help redefine how heterogeneity in antiviral T cell populations gives rise to T cell subsets with short- and long-lived cell fates...
  70. ncbi Activation-induced FOXP3 in human T effector cells does not suppress proliferation or cytokine production
    Sarah E Allan
    Department of Surgery, University of British Columbia, and Immunity and Infection Research Centre, Vancouver Coastal Health Research Institute, 2660 Oak Street, Vancouver, Canada
    Int Immunol 19:345-54. 2007
    ..These data indicate that our current understanding of how FOXP3 contributes to immune tolerance in humans needs to be re-evaluated...
  71. ncbi CD4+CD25high regulatory cells in human peripheral blood
    C Baecher-Allan
    Laboratory of Molecular Immunology, Center for Neurologic Diseases, Brigham and Women s Hospital, Boston, MA 02115
    J Immunol 167:1245-53. 2001
    ....
  72. doi Prostaglandin E2 enhances Th17 responses via modulation of IL-17 and IFN-gamma production by memory CD4+ T cells
    Giorgio Napolitani
    Institute for Research in Biomedicine, Bellinzona, Switzerland
    Eur J Immunol 39:1301-12. 2009
    ....
  73. ncbi CD25 is a marker for CD4+ thymocytes that prevent autoimmune diabetes in rats, but peripheral T cells with this function are found in both CD25+ and CD25- subpopulations
    L A Stephens
    Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom
    J Immunol 165:3105-10. 2000
    ..Phenotypic analysis of human thymocytes showed the presence of CD25+ cells in the same proportions as in rat thymus. The possible developmental relationship between CD25+ and CD25- regulatory T cells is discussed...
  74. pmc Thymic selection determines gammadelta T cell effector fate: antigen-naive cells make interleukin-17 and antigen-experienced cells make interferon gamma
    Kirk D C Jensen
    Department of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA
    Immunity 29:90-100. 2008
    ..The swift IL-17 response mounted by antigen-naive gammadelta T cells suggests a critical role for these cells at the onset of an acute inflammatory response to novel antigens...
  75. ncbi The NOD mouse: a model of immune dysregulation
    Mark S Anderson
    Diabetes Center, University of California, San Francisco, California 94143, USA
    Annu Rev Immunol 23:447-85. 2005
    ..The information gained from this highly relevant model of human disease will lead to potential therapies that may alter the development of the disease and its progression in patients with T1D...
  76. doi A fundamental role for interleukin-21 in the generation of T follicular helper cells
    Alexis Vogelzang
    Department of Immunology, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, NSW 2010, Australia
    Immunity 29:127-37. 2008
    ..This study reveals a previously unappreciated role for Tfh cells in the formation of the GC and isotype switching through a CD4(+) T cell-intrinsic requirement for IL-21...
  77. doi CD4(+)CD25(+)FoxP3(+) regulatory T cells are increased whilst CD3(+)CD4(-)CD8(-)alphabetaTCR(+) Double Negative T cells are decreased in the peripheral blood of patients with multiple myeloma which correlates with disease burden
    Sylvia Feyler
    Transplant Immunology Group, Academic Department of Oncology and Haematology, University of Leeds, Leeds, UK
    Br J Haematol 144:686-95. 2009
    ..This data adds further evidence to the understanding of the role of T(Reg) cell subsets in tumour immunology and the fundamentals of the host/tumour immune conflict...
  78. pmc Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma
    Giao Q Phan
    Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 100:8372-7. 2003
    ..This study establishes CTLA-4 as an important molecule regulating tolerance to "self" antigens in humans and suggests a role for CTLA-4 blockade in breaking tolerance to human cancer antigens for cancer immunotherapy...
  79. pmc Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis
    Vissia Viglietta
    Laboratory of Molecular Immunology, Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 199:971-9. 2004
    ..These data are the first to demonstrate alterations of CD4+CD25hi regulatory T cell function in patients with MS...
  80. pmc Optimization and validation of an 8-color intracellular cytokine staining (ICS) assay to quantify antigen-specific T cells induced by vaccination
    Helen Horton
    Program in Infectious Diseases, Fred Hutchinson Cancer Research Center FHCRC, Seattle, WA 98109, USA
    J Immunol Methods 323:39-54. 2007
    ..In conclusion, we provide the first description of a quantitatively validated ICS assay, which permits quantitative and qualitative evaluation of vaccine-induced immunogenicity and analysis of immune correlates of protection...
  81. doi Grass pollen immunotherapy induces Foxp3-expressing CD4+ CD25+ cells in the nasal mucosa
    Suzana Radulovic
    Department of Upper Respiratory Medicine, Section of Allergy and Clinical Immunology, National Heart and Lung Institute, Imperial College and Royal Brompton Hospital London, London, United Kingdom
    J Allergy Clin Immunol 121:1467-72, 1472.e1. 2008
    ..Regulatory T (Treg) cells play an important role in controlling allergic inflammation. The transcription factor Foxp3 regulates the development and function of natural and adaptive CD4(+)CD25(+) Treg cells...
  82. pmc Interleukin-22 but not interleukin-17 provides protection to hepatocytes during acute liver inflammation
    Lauren A Zenewicz
    Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Immunity 27:647-59. 2007
    ..Our data suggest that IL-22 serves as a protective molecule to counteract the destructive nature of the immune response to limit tissue damage...
  83. ncbi Loss of tolerance and autoimmunity affecting multiple organs in STAT5A/5B-deficient mice
    Jonathan W Snow
    Gladstone Institute of Virology and Immunology, and Department of Microbiology and Immunology, University of California, San Francisco, CA 94114, USA
    J Immunol 171:5042-50. 2003
    ..These data provide strong evidence for a requirement for STAT5 in the maintenance of tolerance in vivo...
  84. ncbi Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting
    H Schorle
    Institute of Virology and Immunobiology, University of Wurzburg, Germany
    Nature 352:621-4. 1991
    ....
  85. ncbi Impaired proliferative response of V alpha 24 NKT cells from cancer patients against alpha-galactosylceramide
    Kazuhiko Yanagisawa
    Department of Surgery, Institute of Clinical Medicine, University of Tsukuba, Tsukuba Science City, Ibaraki, Japan
    J Immunol 168:6494-9. 2002
    ..These results suggest that some functions of NKT cells in cancer patients are impaired, and this observation carries significant implications for immunotherapy-based cancer treatments...
  86. pmc Defective NKT cell development in mice and humans lacking the adapter SAP, the X-linked lymphoproliferative syndrome gene product
    Benoit Pasquier
    Laboratoire du Développement Normal et Pathologique du Système Immunitaire, Unité INSERM 429
    J Exp Med 201:695-701. 2005
    ..They also identify for the first time a defect in NKT cells associated with a human primary immunodeficiency, revealing a potential role of NKT cells in the immune response to EBV...
  87. pmc Interleukin 15 controls both proliferation and survival of a subset of memory-phenotype CD8(+) T cells
    Adam D Judge
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Exp Med 196:935-46. 2002
    ..Thus, subsets of memory-phenotype T cells differ radically in their sensitivity to IL-15...
  88. ncbi TGFbeta1, a "Jack of all trades": the link with pro-inflammatory IL-17-producing T cells
    Marc Veldhoen
    Division of Molecular Immunology, MRC National Institute for Medical Research, London NW7 1AA, UK
    Trends Immunol 27:358-61. 2006
    ..An excess production of Th17 cells in response to infection or trauma could result in leakage into peripheral tissues and cause autoimmune pathology...
  89. ncbi Chemokine receptor expression and function in CD4+ T lymphocytes with regulatory activity
    S Sebastiani
    Laboratory of Immunology, Istituto Dermopatico dell'Immacolata, IRCCS, Rome, Italy
    J Immunol 166:996-1002. 2001
    ....
  90. pmc Delayed maturation of an IL-12-producing dendritic cell subset explains the early Th2 bias in neonatal immunity
    Hyun Hee Lee
    Department of Molecular Microbiology and Immunology, University of Missouri School of Medicine, Columbia, MO 65212, USA
    J Exp Med 205:2269-80. 2008
    ....
  91. ncbi CD4+CD25+ regulatory T cells control the severity of viral immunoinflammatory lesions
    Susmit Suvas
    Department of Microbiology, University of Tennessee, Knoxville, TN 37996, USA
    J Immunol 172:4123-32. 2004
    ..Our results decipher the in vivo role of T(reg) in a virus-induced immunopathology and imply that manipulation of regulatory cell function represents a useful approach to control viral-induced immunoinflammatory disease...
  92. pmc Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages
    Roza I Nurieva
    Department of Immunology, University of Texas MD Anderson Cancer Center and Graduate School of Biomedical Sciences, Houston, TX 77030, USA
    Immunity 29:138-49. 2008
    ..This study thus demonstrates that Tfh is a distinct Th cell lineage...
  93. pmc LAT-mediated signaling in CD4+CD25+ regulatory T cell development
    Surapong Koonpaew
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Exp Med 203:119-29. 2006
    ..Our data indicate that the LAT-PLC-gamma1 interaction plays a critical role in Foxp3 expression and the development of CD4+CD25+ T reg cells...
  94. pmc How regulatory T cells work
    Dario A A Vignali
    Department of Immunology, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee 38105 2794, USA
    Nat Rev Immunol 8:523-32. 2008
    ..In addition, we propose the hypothesis that effector T cells may not be 'innocent' parties in this suppressive process and might in fact potentiate T(Reg)-cell function...
  95. ncbi CD4+ regulatory T cells control TH17 responses in a Stat3-dependent manner
    Ashutosh Chaudhry
    Howard Hughes Medical Institute and Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Science 326:986-91. 2009
    ..These findings suggest that T(regs) adapt to their environment by engaging distinct effector response-specific suppression modalities upon activation of STAT proteins that direct the corresponding class of the immune response...
  96. ncbi B7-H1 is expressed by human endothelial cells and suppresses T cell cytokine synthesis
    Melissa M Mazanet
    Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697, USA
    J Immunol 169:3581-8. 2002
    ..Our results demonstrate that B7-H1 negatively regulates cytokine synthesis in T cells activated by ECs...
  97. ncbi Expression and function of NKG2D in CD4+ T cells specific for human cytomegalovirus
    Andrea Sáez-Borderías
    Molecular Immunopathology Unit, Universitat Pompeu Fabra DCEXS, Barcelona, Spain
    Eur J Immunol 36:3198-206. 2006
    ....
  98. ncbi Vgamma2Vdelta2 T-cell receptor-mediated recognition of aminobisphosphonates
    H Das
    Lymphocyte Biology Section, Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA
    Blood 98:1616-8. 2001
    ....
  99. ncbi Expression and cellular provenance of thymic stromal lymphopoietin and chemokines in patients with severe asthma and chronic obstructive pulmonary disease
    Sun Ying
    King s College London, Division of Asthma, Allergy and Lung Biology, Medical Research Council and Asthma UK Centre in Allergic Mechanisms of Asthma, London, United Kingdom
    J Immunol 181:2790-8. 2008
    ..Increased expression of these chemokines is not, however, associated with selective accumulation of T cells bearing their receptors...
  100. ncbi Gammadelta T cells and the lymphoid stress-surveillance response
    Adrian C Hayday
    London Research Institute, Cancer Research UK, Lincoln s Inn Fields, London WC2A 3PX, UK
    Immunity 31:184-96. 2009
    ....
  101. pmc Upregulation of PD-1 expression on circulating and intrahepatic hepatitis C virus-specific CD8+ T cells associated with reversible immune dysfunction
    Lucy Golden-Mason
    Division of Gastroenterology Hepatology, Hepatitis C Center, University of Colorado Health Sciences Center and National Jewish Hospital, Denver, CO 80262, USA
    J Virol 81:9249-58. 2007
    ..Our data indicate that the PD-1/PD-L pathway is critical in persistent HCV infection in humans and represents a potential novel target for restoring function of exhausted HCV-specific CTLs...

Research Grants68

  1. ANALYSIS OF SPOTTED FEVER RICKETTSIAL ANTIGENS
    David Walker; Fiscal Year: 1993
    ..australis), Israel tick typhus (unnamed Rickettsia sp.), and the recognized Oriental spotted fever (R. japonica) comprise scientifically and medically important diseases that offer a fertile focus of investigation...
  2. ANALYSIS OF SPOTTED FEVER RICKETTSIAL ANTIGENS
    David Walker; Fiscal Year: 1992
    ..australis), Israel tick typhus (unnamed Rickettsia sp.), and the recognized Oriental spotted fever (R. japonica) comprise scientifically and medically important diseases that offer a fertile focus of investigation...
  3. HUMAN T LYMPHOCYTE FUNCTION IN LUPUS ERYTHEMATOSUS
    Gary Kammer; Fiscal Year: 1990
    ..to compare protein kinase A activities in the nonparticulate and particulate fractions of T lymphocytes and T lymphocyte subsets from active and inactive SLE subjects with controls...
  4. OPIATE MODULATION OF PULMONARY INFECTION
    Thomas Molitor; Fiscal Year: 1999
    ..bovis activity of T lymphocyte subsets obtained from BCG-immunized swine; and (4) determine the effect of morphine in BCG-immunized swine on ..
  5. OPIATE MODULATION OF PULMONARY INFECTION
    Thomas Molitor; Fiscal Year: 2000
    ..bovis activity of T lymphocyte subsets obtained from BCG-immunized swine; and (4) determine the effect of morphine in BCG-immunized swine on ..
  6. T CELL FUNCTION IN ANTIVIRAL IMMUNITY
    Mary Graham; Fiscal Year: 1991
    ..These T lymphocyte subsets appear to have different cytokine profiles and may exhibit different functional activity in vivo...
  7. PATHOGENESIS OF FELINE LEUKEMIA VIRUS INDUCED AIDS
    Edward Hoover; Fiscal Year: 1990
    ..monoclonal antibodies will be employed to segregate the feline homologues of the human CD4, CD8, and pan T lymphocyte subsets for in vitro studies of viral susceptibility and cytopathicity, to identify the feline lymphocyte subsets ..
  8. Chemokine Signaling and Colitis in Gia2 Deficient Mice
    Robert Edwards; Fiscal Year: 2002
    ..This application has the support of outstanding mentors at two institutions, and funding of this application will foster Dr Edwards' continued development as a physician-scientist. ..
  9. Chemokine Signaling and Colitis in Gia2 Deficient Mice
    Robert Edwards; Fiscal Year: 2003
    ..This application has the support of outstanding mentors at two institutions, and funding of this application will foster Dr Edwards' continued development as a physician-scientist. ..
  10. Chemokine Signaling and Colitis in Gia2 Deficient Mice
    Robert Edwards; Fiscal Year: 2005
    ..This application has the support of outstanding mentors at two institutions, and funding of this application will foster Dr Edwards' continued development as a physician-scientist. ..
  11. PATHOGENESIS OF FELINE LEUKEMIA VIRUS INDUCED AIDS
    Edward Hoover; Fiscal Year: 1993
    ..monoclonal antibodies will be employed to segregate the feline homologues of the human CD4, CD8, and pan T lymphocyte subsets for in vitro studies of viral susceptibility and cytopathicity, to identify the feline lymphocyte subsets ..
  12. HIV-induced immune activation impairs immune reconstitution through S1P
    Christel H Uittenbogaart; Fiscal Year: 2012
    ..2. To determine whether HIV infection affects egress of nave T lymphocyte subsets from the thymus to the periphery through changes in S1P receptor expression...
  13. ROLE OF DPP1 AND GRANZYMES IN INFLAMMATORY ARTHRITIS
    Christine Pham; Fiscal Year: 2002
    ..cells from arthritic mice will be depleted of CD4+ or CD8+ T cells prior to transfer into SCID mice to elucidate the specific role of T lymphocyte subsets (and granzymes) in the induction and progression of arthritis.
  14. ROLE OF DPP1 AND GRANZYMES IN INFLAMMATORY ARTHRITIS
    Christine Pham; Fiscal Year: 2001
    ..cells from arthritic mice will be depleted of CD4+ or CD8+ T cells prior to transfer into SCID mice to elucidate the specific role of T lymphocyte subsets (and granzymes) in the induction and progression of arthritis.
  15. FACTORS AFFECTING HUMAN LUNG TUMOR GROWTH IN SCID MICE
    Richard Bankert; Fiscal Year: 1991
    ..To address this question T lymphocyte subsets, B lymphocytes, NK cells, and monocytes are selectively eliminated from the tumor either prior to ..
  16. Chemokine Signaling and Colitis in Gia2 Deficient Mice
    Robert Edwards; Fiscal Year: 2006
    ..This application has the support of outstanding mentors at two institutions, and funding of this application will foster Dr Edwards' continued development as a physician-scientist. ..
  17. Chemokine Signaling and Colitis in Gia2 Deficient Mice
    Robert Edwards; Fiscal Year: 2004
    ..This application has the support of outstanding mentors at two institutions, and funding of this application will foster Dr Edwards' continued development as a physician-scientist. ..
  18. T LYMPHOCYTE-WOUND INTERACTIONS IN TRAUMA
    Adrian Barbul; Fiscal Year: 1990
    ..different times post-wounding and determining the subsets present; c) studying the effect of purified wound T lymphocyte subsets harvested at various times post-wounding on in vitro fibroblast activity (replication, chemotaxis, collagen ..
  19. IMMUNOREGULATION & ADAPTATION IN ORGAN TRANSPLANTATION
    Joshua Miller; Fiscal Year: 1980
    ..centrifugation and fluorescence-activated cell sorter analysis to further purify and characterize the T lymphocyte subsets. We will attempt to maintain and retrieve the MLC generated suppressor cell sub-populations by continuous ..
  20. LOCAL CYTOKINE ENVIRONMENT IN ACUTE REJECTION
    CLAUDIA MORGAN; Fiscal Year: 1993
    ..We will study early cytokine expression by T lymphocyte subsets and the expression of antigen-dependent and antigen-independent inflammatory adhesion molecules by ..
  21. Intestinal cytokine&T cell homeostasis in SIV infection
    Satya Dandekar; Fiscal Year: 2007
    ..We propose that the alterations in composition of intestinal T lymphocyte subsets (increased prevalence of CD8+ T cells and inflammatory cytokines such as TNFa) subsequent to CD4+ T cell ..
  22. Intestinal cytokine&T cell homeostasis in SIV infection
    Satya Dandekar; Fiscal Year: 2006
    ..We propose that the alterations in composition of intestinal T lymphocyte subsets (increased prevalence of CD8+ T cells and inflammatory cytokines such as TNFalpha subsequent to CD4+ T cell ..
  23. Intestinal cytokine&T cell homeostasis in SIV infection
    Satya Dandekar; Fiscal Year: 2003
    ..We propose that the alterations in composition of intestinal T lymphocyte subsets (increased prevalence of CD8+ T cells and inflammatory cytokines such as TNFalpha subsequent to CD4+ T cell ..
  24. CHARACTERIZATION OF THE IMMUNOREGULATORY CIRCUITS IN MAN
    Chikao Morimoto; Fiscal Year: 1992
    ..Major recent technical breakthroughs in the molecular characterization of T lymphocyte subsets, and in identification of lymphokines responsible for lymphocyte activation should facilitate the ..
  25. CHARACTERIZATION OF THE IMMUNOREGULATORY CIRCUITS IN MAN
    Chikao Morimoto; Fiscal Year: 1990
    ..Major recent technical breakthroughs in the molecular characterization of T lymphocyte subsets, and in identification of lymphokines responsible for lymphocyte activation should facilitate the ..
  26. CHARACTERIZATION OF THE IMMUNOREGULATORY CIRCUITS IN MAN
    Chikao Morimoto; Fiscal Year: 1991
    ..Major recent technical breakthroughs in the molecular characterization of T lymphocyte subsets, and in identification of lymphokines responsible for lymphocyte activation should facilitate the ..
  27. T CELL FUNCTION IN PULMONARY VIRAL INFECTION & IMMUNITY
    Thomas Braciale; Fiscal Year: 1990
    This application is designed to investigate the function of specific T lymphocyte subsets in the process of recovery from experimental pulmonary viral infection and to ascertain the role of specific lymphokines, particularly interferon ..
  28. T CELL FUNCTION IN PULMONARY VIRAL INFECTION & IMMUNITY
    Thomas Braciale; Fiscal Year: 1992
    This application is designed to investigate the function of specific T lymphocyte subsets in the process of recovery from experimental pulmonary viral infection and to ascertain the role of specific lymphokines, particularly interferon ..
  29. T CELL FUNCTION IN PULMONARY VIRAL INFECTION & INJURY
    Thomas Braciale; Fiscal Year: 1993
    This application is designed to investigate the function of specific T lymphocyte subsets in the process of recovery from experimental pulmonary viral infection and to ascertain the role of specific lymphokines, particularly interferon ..
  30. T LYMPHOCYTE SUBSETS AND HOST DEFENSE AGAINST P CARINII
    JUDD SHELLITO; Fiscal Year: 2000
    ..carinii infection are unknown. This application proposes to investigate the role of T lymphocyte subsets (Th1/Th2) in host responses to this infection. Preliminary data show that clearance of P...
  31. T LYMPHOCYTE SUBSETS AND HOST DEFENSE AGAINST P CARINII
    JUDD SHELLITO; Fiscal Year: 1999
    ..carinii infection are unknown. This application proposes to investigate the role of T lymphocyte subsets (Th1/Th2) in host responses to this infection. Preliminary data show that clearance of P...
  32. EHRLICHIA CHAFFEENSIS SURFACE PROTEINS
    David Walker; Fiscal Year: 2001
    ....
  33. T LYMPHOCYTE SUBSETS AND HOST DEFENSE AGAINST P CARINII
    JUDD SHELLITO; Fiscal Year: 2001
    ..carinii infection are unknown. This application proposes to investigate the role of T lymphocyte subsets (Th1/Th2) in host responses to this infection. Preliminary data show that clearance of P...
  34. INTERFERON AS A MEDIATOR OF CELLULAR IMMUNITY
    LOIS EPSTEIN; Fiscal Year: 1980
    ..parvum stimulated lymphocytes as a measure of the effector competence of T lymphocyte subsets and as a measure of the integrity of macrophage function.
  35. TRANSPLANT IMMUNOLOGY OF IL2 IFNY DOUBLE KNOCKOUT MICE
    Martin Zand; Fiscal Year: 2002
    ..In contrast, if the DKO mice are tolerant to islet allografts, we will determine the mechanism by adoptive transfer of tolerance inducing T lymphocyte subsets.
  36. TRANSPLANT IMMUNOLOGY OF IL2 IFNY DOUBLE KNOCKOUT MICE
    Martin Zand; Fiscal Year: 2000
    ..In contrast, if the DKO mice are tolerant to islet allografts, we will determine the mechanism by adoptive transfer of tolerance inducing T lymphocyte subsets.
  37. COSTIMULATION IN PERIPHERAL T CELL TOLERANCE AND ANERGY
    Jeffrey Bluestone; Fiscal Year: 2000
    ..between receptor-mediated signal transduction pathways that regulate the functions of different T lymphocyte subsets. The Pis will further characterize the signaling block in anergic T cells to produce IL-2...
  38. COSTIMULATION IN PERIPHERAL T CELL TOLERANCE AND ANERGY
    Jeffrey Bluestone; Fiscal Year: 1999
    ..between receptor-mediated signal transduction pathways that regulate the functions of different T lymphocyte subsets. The Pis will further characterize the signaling block in anergic T cells to produce IL-2...
  39. SUPPRESSION OF HEMOPOIESIS BY A NOVEL LYMPHOKINE
    David Tweardy; Fiscal Year: 1990
    ..The ability of their T-lymphocytes and T-lymphocyte subsets to produce CIL and CIL mRNA will be determined...
  40. TRANSPLANT IMMUNOLOGY OF IL2 IFNY DOUBLE KNOCKOUT MICE
    Martin Zand; Fiscal Year: 1999
    ..In contrast, if the DKO mice are tolerant to islet allografts, we will determine the mechanism by adoptive transfer of tolerance inducing T lymphocyte subsets.
  41. TRANSPLANT IMMUNOLOGY OF IL2 IFNY DOUBLE KNOCKOUT MICE
    Martin Zand; Fiscal Year: 2001
    ..In contrast, if the DKO mice are tolerant to islet allografts, we will determine the mechanism by adoptive transfer of tolerance inducing T lymphocyte subsets.
  42. LYMPHOCYTE ENDOTHELIAL INTERACTIONS IN REJECTION
    Charles Orosz; Fiscal Year: 1990
    ..if regionalized lymphocyte-endothelial interactions are responsible for this anatomic segregation of T lymphocyte subsets. 4) determine if selected immunosuppressive drugs which interfere with T cell accumulation at a graft site ..
  43. POST TRANSPLANT T CELL RECONSTITUTION IN NEUROBLASTOMA
    Stephan Grupp; Fiscal Year: 2005
    ..cell reconstitution for patients undergoing SCR and T cell augmentation by measuring: (i) peripheral blood T lymphocyte subsets via flow cytometry, (ii) CD4+ T lymphocyte receptor repertoire via spectratyping, (iii) clinical DTH ..
  44. POST TRANSPLANT T CELL RECONSTITUTION IN NEUROBLASTOMA
    Stephan Grupp; Fiscal Year: 2004
    ..cell reconstitution for patients undergoing SCR and T cell augmentation by measuring: (i) peripheral blood T lymphocyte subsets via flow cytometry, (ii) CD4+ T lymphocyte receptor repertoire via spectratyping, (iii) clinical DTH ..
  45. REGULATION OF GRANULOMA IN TUBERCULOSIS
    Padmini Salgame; Fiscal Year: 1999
    ....
  46. REGULATION OF GRANULOMA IN TUBERCULOSIS
    Padmini Salgame; Fiscal Year: 2000
    ....
  47. REGULATION OF GRANULOMA IN TUBERCULOSIS
    Padmini Salgame; Fiscal Year: 2001
    ....
  48. REGULATION OF GRANULOMA IN TUBERCULOSIS
    Padmini Salgame; Fiscal Year: 2000
    ....
  49. INTRACELLULAR CALCIUM REGULATION IN ALZHEIMER'S DISEASE
    ANGELIKA GROSSMAN; Fiscal Year: 1990
    ....
  50. MECHANISMS OF SURGICAL ADJUVANT INTRAVESICAL BCG
    Timothy Ratliff; Fiscal Year: 1990
    ..Adoptive transfer of T lymphocyte subsets will be performed to identify the population required for antitumor activity...
  51. VIROLOGY AND IMMUNOLOGY OF AGING
    Michael Oldstone; Fiscal Year: 1993
    ..antibodies against self) through a process of "molecular mimicry" and/or through its effects on B or T lymphocyte subsets. In the proposed venture this group will study 1) persistent or latent infection of endocrine, immune and ..
  52. Costimulation in defense against virally induced tumors
    Christian Larsen; Fiscal Year: 2002
    ..Specific Aims: 1) We will determine the role of CD4 and CD8 T lymphocyte subsets in the rejection of SVR tumors in syngeneic mice...