b lymphocyte subsets

Summary

Summary: A classification of B-lymphocytes based on structurally or functionally different populations of cells.

Top Publications

  1. ncbi Lymphotoxin-alpha-dependent spleen microenvironment supports the generation of memory B cells and is required for their subsequent antigen-induced activation
    Y X Fu
    Departments of Laboratory Medicine Pathology and Internal Medicine, and Howard Hughes Medical Institute and Center for Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 164:2508-14. 2000
  2. ncbi The 'short' history of regulatory B cells
    Claudia Mauri
    Department of Medicine, University College London, 46 Cleveland Street, London W1T 4JF, UK
    Trends Immunol 29:34-40. 2008
  3. ncbi TLR-mediated stimulation of APC: Distinct cytokine responses of B cells and dendritic cells
    Tom A Barr
    Institute of Immunology and Infection Research, School of Biological Science, University of Edinburgh, Edinburgh, UK
    Eur J Immunol 37:3040-53. 2007
  4. ncbi IL-10 regulation of lupus in the NZM2410 murine model
    Kim R M Blenman
    Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL 32601-0275, USA
    Lab Invest 86:1136-48. 2006
  5. ncbi Chronic intestinal inflammatory condition generates IL-10-producing regulatory B cell subset characterized by CD1d upregulation
    Atsushi Mizoguchi
    Immunopathology Unit, Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA
    Immunity 16:219-30. 2002
  6. ncbi Defective development and function of Bcl10-deficient follicular, marginal zone and B1 B cells
    Liquan Xue
    Department of Pathology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Nat Immunol 4:857-65. 2003
  7. ncbi Autoreactivity by design: innate B and T lymphocytes
    A Bendelac
    Department of Molecular Biology, Princeton University, New Jersey 08544, USA
    Nat Rev Immunol 1:177-86. 2001
  8. ncbi Follicular lymphoma-like B cells in healthy individuals: a novel intermediate step in early lymphomagenesis
    Sandrine Roulland
    Centre d'Immunologie de Marseille-Luminy, , 13288 Marseille, France
    J Exp Med 203:2425-31. 2006
  9. ncbi The human immunomodulatory CD25+ B cell population belongs to the memory B cell pool
    S Amu
    Department of Rheumatology and Inflammation Research, Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    Scand J Immunol 66:77-86. 2007
  10. ncbi An essential role for BAFF in the normal development of B cells through a BCMA-independent pathway
    B Schiemann
    Biogen, 14 Cambridge Center, Cambridge, MA 02142, USA
    Science 293:2111-4. 2001

Research Grants

  1. IMMUNOGLOBULIN V GENES AND B CELL DEVELOPMENT
    Richard Hardy; Fiscal Year: 2001
  2. LY-1 B CELLS--DEVELOPMENTAL ORIGINS AND V GENE
    Richard Hardy; Fiscal Year: 2000
  3. LY-1 B CELLS: DEVELOPMENTAL ORIGINS AND V GENE BIASES
    Richard Hardy; Fiscal Year: 2007
  4. LY-1 B CELLS--LINEAGE DETERMINATION/ANTIBODY REPERTOIRE
    Richard Hardy; Fiscal Year: 1992
  5. BD Biosciences LSR Flow Cytometer
    Richard Hardy; Fiscal Year: 2002
  6. IMMUNOGLOBULIN V GENES AND B CELL DEVELOPMENT
    Richard Hardy; Fiscal Year: 2006
  7. LY-1 B CELLS: DEVELOPMENTAL ORIGINS AND V GENE BIASES
    Richard Hardy; Fiscal Year: 2005
  8. LY-1 B CELLS: DEVELOPMENTAL ORIGINS AND V GENE BIASES
    Richard R Hardy; Fiscal Year: 2010
  9. LY-1 B-CELLS--DEVELOPMENTAL ORIGINS AND V GENE BIASES
    Richard Hardy; Fiscal Year: 1993
  10. Transitional B cell selection during peripheral B lymphopenia and reconstitution
    MICHAEL PAUL CANCRO; Fiscal Year: 2010

Detail Information

Publications189 found, 100 shown here

  1. ncbi Lymphotoxin-alpha-dependent spleen microenvironment supports the generation of memory B cells and is required for their subsequent antigen-induced activation
    Y X Fu
    Departments of Laboratory Medicine Pathology and Internal Medicine, and Howard Hughes Medical Institute and Center for Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 164:2508-14. 2000
    ....
  2. ncbi The 'short' history of regulatory B cells
    Claudia Mauri
    Department of Medicine, University College London, 46 Cleveland Street, London W1T 4JF, UK
    Trends Immunol 29:34-40. 2008
    ..The identification of their existence is of great relevance to the understanding of autoimmune diseases and to the development of new therapeutic strategies...
  3. ncbi TLR-mediated stimulation of APC: Distinct cytokine responses of B cells and dendritic cells
    Tom A Barr
    Institute of Immunology and Infection Research, School of Biological Science, University of Edinburgh, Edinburgh, UK
    Eur J Immunol 37:3040-53. 2007
    ..QRT-PCR array data indicate that this may be due to differential expression of TLR signalling molecules, effectors and adaptors. Our data highlight the potentially unique nature of immune modulation when B cells act as APC...
  4. ncbi IL-10 regulation of lupus in the NZM2410 murine model
    Kim R M Blenman
    Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL 32601-0275, USA
    Lab Invest 86:1136-48. 2006
    ..These results also reinforce the notion that IL-10 exerts multiple functions and commend caution in equating high levels of IL-10 and increased pathogenesis in systemic autoimmunity...
  5. ncbi Chronic intestinal inflammatory condition generates IL-10-producing regulatory B cell subset characterized by CD1d upregulation
    Atsushi Mizoguchi
    Immunopathology Unit, Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA
    Immunity 16:219-30. 2002
    ..This study indicates that B cells, by producing cytokines such as IL-10, can act as regulatory cells in immunologically mediated inflammatory reactions...
  6. ncbi Defective development and function of Bcl10-deficient follicular, marginal zone and B1 B cells
    Liquan Xue
    Department of Pathology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Nat Immunol 4:857-65. 2003
    ..Thus, Bcl10 is essential for the development of all mature B cell subsets...
  7. ncbi Autoreactivity by design: innate B and T lymphocytes
    A Bendelac
    Department of Molecular Biology, Princeton University, New Jersey 08544, USA
    Nat Rev Immunol 1:177-86. 2001
    ..New studies have shed light on the principles and mechanisms that drive their unique development and function, and show their resemblance to another subset of innate lymphocytes, the natural killer cells...
  8. ncbi Follicular lymphoma-like B cells in healthy individuals: a novel intermediate step in early lymphomagenesis
    Sandrine Roulland
    Centre d'Immunologie de Marseille-Luminy, , 13288 Marseille, France
    J Exp Med 203:2425-31. 2006
    ..These findings strongly impact both on the current understanding of disease progression and on the proper handling of t(14;18) frequency in blood as a potential early biomarker for lymphoma...
  9. ncbi The human immunomodulatory CD25+ B cell population belongs to the memory B cell pool
    S Amu
    Department of Rheumatology and Inflammation Research, Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    Scand J Immunol 66:77-86. 2007
    ..In conclusion, CD20(+)25(+) B cells constitute a unique subpopulation preferentially occurring among CD20(+)27(+) memory B cells. We suggest that CD25 can be used as a marker for a memory B cell subset...
  10. ncbi An essential role for BAFF in the normal development of B cells through a BCMA-independent pathway
    B Schiemann
    Biogen, 14 Cambridge Center, Cambridge, MA 02142, USA
    Science 293:2111-4. 2001
    ..In contrast, mice lacking BCMA had normal-appearing B lymphocyte compartments. BAFF therefore plays a crucial role in B cell development and can function through receptors other than BCMA...
  11. ncbi Cutting edge commentary: origins of B-1 cells
    H H Wortis
    Department of Pathology, Tufts University School of Medicine and Program in Immunology, Sackler School of Graduate Biomedical Sciences, Boston MA 02111, USA
    J Immunol 166:2163-6. 2001
    ..CD5 expression and possibly localization to the peritoneum appear to provide some protection to autoreactive cells otherwise slated for elimination...
  12. ncbi Regulation and function of cyclin D2 in B lymphocyte subsets
    Thomas C Chiles
    Department of Biology, Boston College, Chestnut Hill, MA 02467, USA
    J Immunol 173:2901-7. 2004
    ..This review focuses on recent progress toward understanding the function of cyclin D2 in cell cycle control, and in the development of murine B lymphocytes...
  13. ncbi Germinal centers regulate human Th2 development
    Bengt Johansson-Lindbom
    Department of Immunotechnology, Lund University, Lund, Sweden
    J Immunol 171:1657-66. 2003
    ....
  14. ncbi Transitional type 1 and 2 B lymphocyte subsets are differentially responsive to antigen receptor signaling
    James B Petro
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, USA
    J Biol Chem 277:48009-19. 2002
    ..In turn, these signaling pathways probably govern the development and selection processes that are critical for the formation of the mature B cell compartment...
  15. ncbi Toll-like receptor expression and responsiveness of distinct murine splenic and mucosal B-cell subsets
    Murali Gururajan
    Vaccine Research Center, Emory University, Atlanta, Georgia, United States of America
    PLoS ONE 2:e863. 2007
    ..Furthermore, the expression and functional relevance of TLRs on distinct subsets of B cells, which are known to play differential roles in humoral responses is not known...
  16. ncbi CD1 expression defines subsets of follicular and marginal zone B cells in the spleen: beta 2-microglobulin-dependent and independent forms
    M Amano
    Department of Medicine, Stanford University School of Medicine, CA 94305 5111, USA
    J Immunol 161:1710-7. 1998
    ..They further suggest that a beta 2m-independent form of CD1 is expressed on B cells that can stimulate T cells; however, this form is not easily visualized with the anti-CD1 mAb used here...
  17. ncbi TLR agonists selectively promote terminal plasma cell differentiation of B cell subsets specialized in thymus-independent responses
    Laurent Genestier
    Institut National de la Santé et de la Recherche Médicale Unité 851, IFR128 Biosciences Lyon Gerland, 21 Avenue Tony Garnier, Lyon, France
    J Immunol 178:7779-86. 2007
    ....
  18. ncbi B cells acquire particulate antigen in a macrophage-rich area at the boundary between the follicle and the subcapsular sinus of the lymph node
    Yolanda R Carrasco
    Lymphocyte Interaction Laboratory, Cancer Research United Kingdom London Research Institute, Lincoln s Inn Fields Laboratories, 44 Lincoln s Inn Fields, London WC2A 3PX, United Kingdom
    Immunity 27:160-71. 2007
    ..These observations not only provide evidence of a B cell role as antigen transporters into the follicle, but also highlight the boundary between the follicle and the SCS as a site for initiation of B cell responses...
  19. ncbi Helicobacter pylori vacuolating cytotoxin inhibits activation-induced proliferation of human T and B lymphocyte subsets
    Victor J Torres
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232 2605, USA
    J Immunol 179:5433-40. 2007
    ..We propose that the immunomodulatory actions of VacA on T and B lymphocytes, the major effectors of the adaptive immune response, may contribute to the ability of H. pylori to establish a persistent infection in the human gastric mucosa...
  20. ncbi Siglec-G is a B1 cell-inhibitory receptor that controls expansion and calcium signaling of the B1 cell population
    Anja Hoffmann
    Department of Genetics, University of Erlangen, 91058 Erlangen, Germany
    Nat Immunol 8:695-704. 2007
    ..Siglec-G-deficient B1 cells showed a strongly enhanced calcium signaling. Our results demonstrate that Siglec-G-dependent negative regulation exists in B1 cells, which may explain the naturally muted signaling response of B1 cells...
  21. ncbi BAFF-modulated repopulation of B lymphocytes in the blood and salivary glands of rituximab-treated patients with Sjögren's syndrome
    Jacques Olivier Pers
    Brest University Medical School, Brest, France
    Arthritis Rheum 56:1464-77. 2007
    ..The purpose of this study was to track the repopulation of B cell subsets in PB as well as their subsequent homing into SGs in patients with primary SS treated with rituximab...
  22. ncbi Replication history of B lymphocytes reveals homeostatic proliferation and extensive antigen-induced B cell expansion
    Menno C van Zelm
    Erasmus MC, Department of Immunology, 3015 GE Rotterdam, Netherlands
    J Exp Med 204:645-55. 2007
    ..We quantified the replication history of mouse and human B lymphocyte subsets by calculating the ratio between genomic coding joints and signal joints on kappa-deleting recombination ..
  23. ncbi Regulatory role of B-1 B cells in chronic colitis
    Yasuyo Shimomura
    Experimental Pathology, Massachusetts General Hospital, Boston, MA 02114, USA
    Int Immunol 20:729-37. 2008
    ..We conclude that B-1 cells play a regulatory role in T(h)2-mediated colitis under non-hygienic conditions, possibly by generating natural antibodies in response to microbial flora...
  24. ncbi A role for Toll-like receptors in acquired immunity: up-regulation of TLR9 by BCR triggering in naive B cells and constitutive expression in memory B cells
    Nadia L Bernasconi
    Institute for Research in Biomedicine, Bellinzona, Switzerland
    Blood 101:4500-4. 2003
    ..Thus, in human B cells TLRs are downstream of BCR and play a role both in the primary response and in the memory phase...
  25. ncbi Regulatory mechanisms that determine the development and function of plasma cells
    Kathryn L Calame
    Department of Microbiology and Biochemistry, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Annu Rev Immunol 21:205-30. 2003
    ..Thus, commitment to plasmacytic differentiation involves inhibition of activities associated with earlier B cell developmental stages as well as expression of the plasma cell phenotype...
  26. ncbi A division-linked mechanism for the rapid generation of Ig-secreting cells from human memory B cells
    Stuart G Tangye
    Immune Regulation Group, Centenary Institute of Cancer Medicine and Cell Biology, Sydney, New South Wales, Australia
    J Immunol 170:261-9. 2003
    ....
  27. ncbi Naive B lymphocytes undergo homeostatic proliferation in response to B cell deficit
    Mark S Cabatingan
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Immunol 169:6795-805. 2002
    ..Homeostatic B cell proliferation provides an Ag-independent mechanism for the maintenance and expansion of naive B cells selected into the mature B cell pool...
  28. ncbi Anti-CD20 therapy in patients with rheumatoid arthritis: predictors of response and B cell subset regeneration after repeated treatment
    Petra Roll
    University of Wurzburg, Wurzburg, Germany
    Arthritis Rheum 58:1566-75. 2008
    ..The effects on B cell homeostasis after repeated treatments and the relationship of certain B cell subsets to clinical response or relapse are currently not known...
  29. ncbi Identification of transitional type II B cells in the salivary glands of patients with Sjögren's syndrome
    Capucine Daridon
    Laboratory of Immunology, Brest University Medical School Hospital, BP824, F 29609 Brest, France
    Arthritis Rheum 54:2280-8. 2006
    ..A special emphasis was placed on those B lymphocytes included in the ectopic germinal centers (GCs)...
  30. ncbi Perturbations of peripheral B lymphocyte homoeostasis in children with systemic lupus erythematosus
    M Odendahl
    Deutsches Rheuma-Forschungszentrum Berlin, Germany
    Ann Rheum Dis 62:851-8. 2003
    ..Thus detection of CD27(high) plasma blasts significantly correlates with active lupus in both children and adults...
  31. ncbi TNF deficiency fails to protect BAFF transgenic mice against autoimmunity and reveals a predisposition to B cell lymphoma
    Marcel Batten
    Department of Arthritis and Inflammation, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, New South Wales 2010, Australia
    J Immunol 172:812-22. 2004
    ....
  32. ncbi B-1a and B-1b cells exhibit distinct developmental requirements and have unique functional roles in innate and adaptive immunity to S. pneumoniae
    Karen M Haas
    Department of Immunology, Box 3010, Duke University Medical Center, Durham, North Carolina 27710, USA
    Immunity 23:7-18. 2005
    ..This reciprocal contribution of B-1a and B-1b subsets to innate and acquired immunity reveals an unexpected division of labor within the B-1 compartment that is normally balanced by their coordinated development...
  33. ncbi Expanded population of activated antigen-engaged cells within the naive B cell compartment of patients with systemic lupus erythematosus
    Nan Hua Chang
    Arthritis Centre of Excellence, Toronto Western Hospital Research Institute, and Department of Medicine, University of Toronto, Ontario, Canada
    J Immunol 180:1276-84. 2008
    ..Although controls also had IgD+IgMlowCD23+ cells, they were reduced in number and not activated. Thus, there is an altered response to Ig receptor engagement with self-Ags in lupus...
  34. ncbi Short-lived plasmablasts dominate the early spontaneous rheumatoid factor response: differentiation pathways, hypermutating cell types, and affinity maturation outside the germinal center
    Jacqueline William
    Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    J Immunol 174:6879-87. 2005
    ..These studies provide insights into the unique nature of an ongoing autoimmune response and may be a model for understanding the response to therapies such as B cell depletion...
  35. ncbi Depletion of B cells by a humanized anti-CD20 antibody PRO70769 in Macaca fascicularis
    Yulia Vugmeyster
    Genentech, Inc, South San Francisco, California 94080, USA
    J Immunother (1997) 28:212-9. 2005
    ..After recovery, B-cell subsets were reconstituted to normal levels. Depletion of CD20-expressing cells and lymphoid follicular atrophy were the only treatment-related effects...
  36. ncbi Activation of marginal zone B cells from lupus mice with type A(D) CpG-oligodeoxynucleotides
    Rachel Brummel
    Division of Rheumatology, Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    J Immunol 174:2429-34. 2005
    ..Through increased IL-10 secretion, MZ-B cells may also modify the activity of other cell types, particularly dendritic cells and macrophages...
  37. ncbi B lymphocyte depletion by CD20 monoclonal antibody prevents diabetes in nonobese diabetic mice despite isotype-specific differences in Fc gamma R effector functions
    Yan Xiu
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 180:2863-75. 2008
    ..Moreover, this study defines a new, clinically relevant approach whereby B cell depletion early in the course of disease development may prevent diabetes or delay progression of disease...
  38. ncbi Synovial tissue response to rituximab: mechanism of action and identification of biomarkers of response
    R M Thurlings
    Division of Clinical Immunology and Rheumatology, Academic Medical Center University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Ann Rheum Dis 67:917-25. 2008
    ..To investigate the synovial tissue in patients with rheumatoid arthritis (RA) treated with rituximab and to identify possible predictors of clinical response...
  39. ncbi Uncoupling of anergy from developmental arrest in anti-insulin B cells supports the development of autoimmune diabetes
    Carlos A Acevedo-Suárez
    Department of Medicine, Vanderbilt University, Nashville, TN 37232, USA
    J Immunol 174:827-33. 2005
    ..These findings suggest that the degree of functional impairment, rather than an overt breach of tolerance, is a critical feature that governs B cell contribution to T cell-mediated autoimmune disease...
  40. ncbi Regulation of BCR signal transduction in B-1 cells requires the expression of the Src family kinase Lck
    Joseph M Dal Porto
    Integrated Department of Immunology, National Jewish Medical and Research Center, University of Colorado School of Medicine, Denver 80206, USA
    Immunity 21:443-53. 2004
    ..Interestingly, lck-null mice exhibited increased natural antibody levels characteristic of B-1 cells. Taken together, these results demonstrate a key role for Lck in modulating the signaling and cellular fate of B-1 B cells...
  41. ncbi A case for regulatory B cells
    Atsushi Mizoguchi
    Immunopathology Unit, Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Immunol 176:705-10. 2006
    ..In this review, we make a case for the existence of regulatory B cells and discuss the possible developmental pathways and functional mechanisms of these B cells...
  42. ncbi Recapitulation of B cell differentiation in the central nervous system of patients with multiple sclerosis
    Anna Corcione
    Laboratory of Oncology, Scientific Direction, G Gaslini Institute, 16148 Genoa, Italy
    Proc Natl Acad Sci U S A 101:11064-9. 2004
    ..The presence of lymphotoxin-alpha, CXCL12, and CXCL13 in the CNS may provide favorable microenvironmental conditions for these events...
  43. ncbi Innate-like B cells
    John F Kearney
    Division of Developmental and Clinical Immunology, Department of Microbiology, University of Alabama at Birmingham, WTI 378, 1824 6th Avenue South, Birmingham, AL 35294 3300, USA
    Springer Semin Immunopathol 26:377-83. 2005
    ..These innate-like B cell subsets form a bridge between the rapidly occurring innate immune responses, and the slower acting primary, T cell-dependent, adaptive antibody response by providing a rapid T cell-independent antibody response...
  44. ncbi Blood dendritic cells interact with splenic marginal zone B cells to initiate T-independent immune responses
    Mercedesz Balazs
    Division of Developmental and Clinical Immunology, Department of Microbiology, University of Alabama, Birmingham, AL 35294, USA
    Immunity 17:341-52. 2002
    ..In the absence of soluble TACI ligands, Ag-activated MZ- and B1-derived blasts lack survival signals and undergo apoptosis, resulting in severely impaired antibody responses...
  45. ncbi B1 cells: similarities and differences with other B cell subsets
    F Martin
    Division of Developmental and Clinical Immunology, Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294-3300, USA
    Curr Opin Immunol 13:195-201. 2001
    ..Most advances have been made in describing the physiological activities of B1 cells, including their migration, activation by antigen and role in both autoimmunity and malignancy...
  46. ncbi From the fetal liver to spleen and gut: the highway to natural antibody
    M M Rosado
    Research Center, Ospedale Pediatrico Bambino Gesu, IRCCS, Roma, Italy
    Mucosal Immunol 2:351-61. 2009
    ..The natural antibodies in the serum and on the intestinal epithelium may be an evolutionary ancient tool for the immediate protection against commensal and pathogenic bacteria...
  47. ncbi Immunological defects in mice with a targeted disruption in Bcl-3
    E M Schwarz
    Laboratory of Genetics, The Salk Institute, San Diego, California 92186 5800, USA
    Genes Dev 11:187-97. 1997
    ..Additionally, spleens from Bcl-3(-/-) mice are abnormal and void of germinal centers. In contrast, the p50(-/-) mice have normal germinal centers. We propose that in in vivo, Bcl-3 can function independently of p50...
  48. ncbi The Rac2 guanosine triphosphatase regulates B lymphocyte antigen receptor responses and chemotaxis and is required for establishment of B-1a and marginal zone B lymphocytes
    Ben A Croker
    Division of Cancer and Hematology and Immunology, Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Parkville, Victoria, Australia
    J Immunol 168:3376-86. 2002
    ..Rac2 is therefore an essential element in regulating B lymphocyte functions and maintaining B lymphocyte populations in vivo...
  49. ncbi B cell development in the spleen takes place in discrete steps and is determined by the quality of B cell receptor-derived signals
    F Loder
    Department of Molecular Immunology, University of Freiburg, Germany
    J Exp Med 190:75-89. 1999
    ....
  50. ncbi B cell life span: a review
    D A Fulcher
    Centenary Institute of Cancer Medicine and Cell Biology, Sydney, New South Wales, Australia
    Immunol Cell Biol 75:446-55. 1997
    ..This review examines both traditional and recent methods and discusses the influence of age, self-tolerance and randomness in the overall shaping of a kinetically stable mature B cell population...
  51. ncbi Regulatory B cells as inhibitors of immune responses and inflammation
    Jean David Bouaziz
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    Immunol Rev 224:201-14. 2008
    ..This review focuses on the recent progress in this field and the exciting opportunities for understanding how this unique B-cell subset influences diverse immune functions...
  52. ncbi BLyS: member of the tumor necrosis factor family and B lymphocyte stimulator
    P A Moore
    Human Genome Sciences, 9410 Key West Avenue, Rockville, MD 20850, USA
    Science 285:260-3. 1999
    ..The B cell tropism of BLyS is consistent with its receptor expression on B-lineage cells. The biological profile of BLyS suggests it is involved in monocyte-driven B cell activation...
  53. ncbi Lupus-specific antiribonucleoprotein B cell tolerance in nonautoimmune mice is maintained by differentiation to B-1 and governed by B cell receptor signaling thresholds
    Y Qian
    Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC 27599, USA
    J Immunol 166:2412-9. 2001
    ..These results suggest a differentiation scheme in which peripheral ignorance to Sm is maintained in mice by the differentiation of anti-Sm B cells to B-1 cells that have increased activation thresholds...
  54. ncbi HLA-DRhigh/CD27high plasmablasts indicate active disease in patients with systemic lupus erythematosus
    A M Jacobi
    Charite Universitatsmedizin Berlin, Chariteplatz 1, 10098 Berlin, Germany
    Ann Rheum Dis 69:305-8. 2010
    ..A similar subset has also been identified 6-8 days after tetanus/diphtheria vaccination in normal individuals and in patients with infectious disease...
  55. ncbi Categorical selection of the antibody repertoire in splenic B cells
    Robert L Schelonka
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35233 1530, USA
    Eur J Immunol 37:1010-21. 2007
    ....
  56. ncbi Is the blood B-cell subset profile diagnostic for Sjogren syndrome?
    A Binard
    EA Immunologie et Pathologie, Universite Europeenne de Bretagne, et Université de Bretagne Occidentale, Brest, et Centre Hospitalier Universitaire de Brest, Brest F29609, France
    Ann Rheum Dis 68:1447-52. 2009
    ..To evaluate the relevance of the blood B-cell subset profile for the diagnosis of Sjögren syndrome...
  57. ncbi B-cell subsets and the mature preimmune repertoire. Marginal zone and B1 B cells as part of a "natural immune memory"
    F Martin
    University of Alabama at Birmingham, 35294 3300, USA
    Immunol Rev 175:70-9. 2000
    ....
  58. ncbi Discriminating gene expression profiles of memory B cell subpopulations
    Gotz R A Ehrhardt
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Exp Med 205:1807-17. 2008
    ....
  59. ncbi B cells in autoimmunity
    Thomas Dorner
    Charite Center 12 and 14, Charite University Hospital and DRFZ Berlin, Chariteplatz 01, 10098 Berlin, Germany
    Arthritis Res Ther 11:247. 2009
    ..Based on preclinical and clinical data, B cells have emerged increasingly as both effector cells as well as cells with immunoregulatory potential...
  60. ncbi CD27 expression by a distinct subpopulation of human B lymphocytes
    D Maurer
    Institute of Immunology, Vienna International Research Cooperation Center, Austria
    Eur J Immunol 20:2679-84. 1990
    ..These latter findings suggest that CD27+ B cells are predispose to form cell-cell interactions. Accordingly, within 3 h of cell culture CD27+, but not CD27-, B lymphocytes were found to form LFA-1-mediated homotypic B cell clusters...
  61. ncbi Diminished peripheral blood memory B cells and accumulation of memory B cells in the salivary glands of patients with Sjögren's syndrome
    Arne Hansen
    University Hospital Charit, Berlin, Germany
    Arthritis Rheum 46:2160-71. 2002
    ..It is possible that preferential accumulation of CD27+ memory B cells in the inflamed parotid gland explains their reduction in the peripheral blood...
  62. ncbi Disruption of the Cr2 locus results in a reduction in B-1a cells and in an impaired B cell response to T-dependent antigen
    J M Ahearn
    Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Immunity 4:251-62. 1996
    ..These results indicate an obligatory role of B cell complement receptors in responses of the B cells to protein antigens...
  63. ncbi Mac-1-negative B-1b phenotype of natural antibody-producing cells, including those responding to Gal alpha 1,3Gal epitopes in alpha 1,3-galactosyltransferase-deficient mice
    H Ohdan
    Transplantation Biology Research Center, Surgical Service, Massachusetts General Hospital Harvard Medical School, Boston, MA 02129, USA
    J Immunol 165:5518-29. 2000
    ..They are consistent with a model whereby B-1b cells lose Mac-1 expression upon Ag exposure and that these, rather than plasma cells, become the major IgM Ab-producing cell population...
  64. ncbi The role of Fas in the immune system biology of IL-2R alpha knockout mice: interplay among regulatory T cells, inflammation, hemopoiesis, and apoptosis
    Rahul Sharma
    Division of Rheumatology and Immunology, Department of Internal Medicine, University of Virginia, Charlottesville, VA 22908 0412, USA
    J Immunol 175:1965-73. 2005
    ....
  65. ncbi Augmentation of antigen receptor-mediated responses by histamine H1 receptor signaling
    Y Banu
    Department of Molecular Immunology, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812 8582, Japan
    J Exp Med 189:673-82. 1999
    ..Collectively, these results imply that the signal generated by histamine through H1R augments antigen receptor-mediated immune responses, suggesting cross-talk between G protein-coupled receptors and antigen receptor-mediated signaling...
  66. ncbi Genetic dissection of systemic lupus erythematosus pathogenesis: partial functional complementation between Sle1 and Sle3/5 demonstrates requirement for intracellular coexpression for full phenotypic expression of lupus
    Masatoshi Wakui
    Department of Medicine and Division of Rheumatology and Clinical Immunology, College of Medicine, University of Florida, Gainesville, FL 32610, USA
    J Immunol 175:1337-45. 2005
    ..Our mixed chimera approach continues to provide novel insights into the functional genetic pathways underlying this important murine model of systemic autoimmunity...
  67. ncbi TLR agonists promote marginal zone B cell activation and facilitate T-dependent IgM responses
    Anatoly V Rubtsov
    Integrated Department of Immunology, University of Colorado Denver and National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Immunol 180:3882-8. 2008
    ..Together, these data demonstrate that in vivo TLR agonist treatment enhances the early production of Ag-specific IgM and activates MZ B cells to promote their relocation...
  68. ncbi B cells from mice prematurely expressing human complement receptor type 2 are unresponsive to T-dependent antigens
    Louise Birrell
    Department of Medical Biochemistry and Immunology, School of Medicine, Cardiff University, UK
    J Immunol 174:6974-82. 2005
    ..We conclude that this phenotype and these mice may offer an additional means to dissect mechanisms underlying B cell tolerance and Ag responsiveness both in bone marrow and periphery...
  69. ncbi Several genes contribute to the production of autoreactive B and T cells in the murine lupus susceptibility locus Sle1c
    Yifang Chen
    Department of Pathology, Immunology, and Laboratory Medicine, Department of Medicine, University of Florida, Gainesville, FL 32610, USA
    J Immunol 175:1080-9. 2005
    ....
  70. ncbi CD72-deficient mice reveal nonredundant roles of CD72 in B cell development and activation
    C Pan
    Department of Medicine, Stanford University School of Medicine, California 94305, USA
    Immunity 11:495-506. 1999
    ..In addition, CD72 is a negative regulator of B cell activation, as CD72-/- B cells were hyperproliferative in response to various stimuli and showed enhanced kinetics in their intracellular Ca2+ response following IgM cross-linking...
  71. ncbi Pre-B cell receptor-mediated selection of pre-B cells synthesizing functional mu heavy chains
    G H Kline
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunol 161:1608-18. 1998
    ..Therefore, we propose a new function of SL chain in early B cell development: SL chain is part of a quality control mechanism that tests a mu-chain for its ability to pair with conventional L chains...
  72. ncbi Enhanced immune reconstitution by sex steroid ablation following allogeneic hemopoietic stem cell transplantation
    Gabrielle L Goldberg
    Department of Pathology and Immunology, Central and Eastern Clinical School, Monash University, Melbourne, Australia
    J Immunol 178:7473-84. 2007
    ..These results indicate that sex steroid ablation can profoundly enhance thymic and hemopoietic recovery following allogeneic HSCT without increasing GVHD and maintaining GVT...
  73. ncbi Modulation of hematopoiesis in mice with a truncated mutant of the interleukin-2 receptor gamma chain
    K Ohbo
    Department of Microbiology, Tohoku University School of Medicine, Sendai, Japan
    Blood 87:956-67. 1996
    ..These results indicate that functional loss of the gamma chain causes significant effects on the immunological system in mice...
  74. ncbi Puma cooperates with Bim, the rate-limiting BH3-only protein in cell death during lymphocyte development, in apoptosis induction
    Miriam Erlacher
    Division of Developmental Immunology, Biocenter, Innsbruck Medical University, A 6020 Innsbruck, Austria
    J Exp Med 203:2939-51. 2006
    ..Their combined loss promotes spontaneous tumorigenesis, causing the malignancies observed in Bcl-2 transgenic mice, but does not exacerbate the autoimmunity observed in the absence of Bim...
  75. ncbi The germinal center response is impaired in the absence of T cell-expressed CXCR5
    Carrie N Arnold
    Department of Pathology, Laboratory of Immunology and Vascular Biology, Stanford University School of Medicine, Stanford, CA, USA
    Eur J Immunol 37:100-9. 2007
    ....
  76. ncbi Modulation of autoimmunity by TLR9 in the chronic graft-vs-host model of systemic lupus erythematosus
    Zhongjie Ma
    Division of Rheumatology, Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104 6160, USA
    J Immunol 177:7444-50. 2006
    ..56R and B6.56R.TLR9(-/-) postinduction of cGVH disease. Taken together, these results suggested that TLR9 may worsen some aspects of systemic autoimmunity while alleviating others...
  77. ncbi Double-negative T cells, activated by xenoantigen, lyse autologous B and T cells using a perforin/granzyme-dependent, Fas-Fas ligand-independent pathway
    Zhu Xu Zhang
    Department of Surgery, University of Western Ontario, London, Ontario, Canada
    J Immunol 177:6920-9. 2006
    ..In conclusion, this study suggests that xenoreactive DNT cells can control B and T cell responses in perforin/granzyme-dependent mechanisms. DNT cells may be valuable in controlling B and T cell responses in xenotransplantation...
  78. ncbi Architectural defects in the spleens of Nkx2-3-deficient mice are intrinsic and associated with defects in both B cell maturation and T cell-dependent immune responses
    David Tarlinton
    Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    J Immunol 170:4002-10. 2003
    ..Collectively, these data indicate a substantial role for Nkx2-3 in the correct association of lymphocytes and splenic stromal elements that is independent of chemokine expression...
  79. ncbi MOP3, a component of the molecular clock, regulates the development of B cells
    Yimin Sun
    Department of Surgery, University of Nebraska Medical Center, Omaha, NE, USA
    Immunology 119:451-60. 2006
    ..This study also showed a connection between a master regular of circadian rhythm with B-cell development in mice...
  80. ncbi Formation of B and T cell subsets require the cannabinoid receptor CB2
    David Ziring
    Department of Pediatrics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
    Immunogenetics 58:714-25. 2006
    ....
  81. ncbi Mice deficient in nuclear factor (NF)-kappa B/p52 present with defects in humoral responses, germinal center reactions, and splenic microarchitecture
    G Franzoso
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892 USA
    J Exp Med 187:147-59. 1998
    ..Possible roles of p52 and Bcl-3 are discussed that may underlie the oncogenic potential of these proteins, as evidenced by recurrent chromosomal translocations of their genes in lymphoid tumors...
  82. ncbi Mature B cells preferentially lose tolerance in the chronic graft-versus-host disease model of systemic lupus erythematosus
    Arpita Choudhury
    Department of Medicine, Division of Rheumatology, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Immunol 179:5564-70. 2007
    ..This observation underscores the critical role of marginal zone B cells in activation and production of autoantibodies...
  83. ncbi Nuclear factor (NF)-kappa B2 (p100/p52) is required for normal splenic microarchitecture and B cell-mediated immune responses
    J H Caamaño
    Department of Oncology, Bristol Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey 08543 4000, USA
    J Exp Med 187:185-96. 1998
    ..These findings indicate an important role of NF-kappa B2 in the maintenance of the peripheral B cell population, humoral responses, and normal spleen architecture...
  84. ncbi B-1 cell development: evidence for an uncommitted immunoglobulin (Ig)M+ B cell precursor in B-1 cell differentiation
    S H Clarke
    Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    J Exp Med 187:1325-34. 1998
    ..Since xid mice exhibit defective B cell differentiation, not programmed cell death, these data are most consistent with an inability of PtC-specific B-0 cells to convert to B-1 and a single B cell lineage...
  85. ncbi The role of ICOS in the CXCR5+ follicular B helper T cell maintenance in vivo
    Hisaya Akiba
    Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan
    J Immunol 175:2340-8. 2005
    ..These results indicated that the ICOS/B7RP-1 interaction plays an essential role in the development of CXCR5+ T(FH) cells in vivo...
  86. ncbi B cell development and activation defects resulting in xid-like immunodeficiency in BLNK/SLP-65-deficient mice
    S Xu
    Institute of Molecular and Cell Biology, National University of Singapore, 30 Medical Drive, Singapore 117609, Republic of Singapore
    Int Immunol 12:397-404. 2000
    ..This raises the interesting possibility that mutation in BLNK/SLP-65 may be responsible for certain human immunodeficiencies...
  87. ncbi Maintenance of long term gamma-herpesvirus B cell latency is dependent on CD40-mediated development of memory B cells
    In-Jeong Kim
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Immunol 171:886-92. 2003
    ..These data directly demonstrate viral exploitation of the normal B cell differentiation pathway to maintain latency...
  88. ncbi IKK beta is required for peripheral B cell survival and proliferation
    Zhi Wei Li
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, Cancer Center, University of California San Diego, La Jolla, CA 92093, USA
    J Immunol 170:4630-7. 2003
    ..Thus, IKKbeta provides a requisite role in B cell activation and maintenance and thus is a key determinant of humoral immunity...
  89. ncbi A role for CCR9 in T lymphocyte development and migration
    Shoji Uehara
    Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development, and Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892
    J Immunol 168:2811-9. 2002
    ..Thus, CCR9 plays an important, although not indispensable, role in regulating the development and/or migration of both alphabeta(-) and gammadelta(-) T lymphocytes...
  90. ncbi The resolution of relapsing fever borreliosis requires IgM and is concurrent with expansion of B1b lymphocytes
    Kishore R Alugupalli
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Immunol 170:3819-27. 2003
    ..hermsii. Together these results support the model that B1b cells generate the T-independent IgM required for the control and resolution of relapsing fever borreliosis...
  91. ncbi BATF transgenic mice reveal a role for activator protein-1 in NKT cell development
    Kristi L Williams
    Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA
    J Immunol 170:2417-26. 2003
    ....
  92. ncbi The Yaa mutation promoting murine lupus causes defective development of marginal zone B cells
    Hirofumi Amano
    Department of Pathology, University of Geneva, Geneva, Switzerland
    J Immunol 170:2293-301. 2003
    ....
  93. ncbi B cell developmental requirement for the G alpha i2 gene
    Harnisha Dalwadi
    Department of Pathology and Laboratory Medicine, School of Medicine, University of California Los Angeles, Los Angeles, CA 90095 1732, USA
    J Immunol 170:1707-15. 2003
    ..Collectively, these results reveal a selective role for Galphai2 in MZ and B-1 B cell development. Disorders of this Galphai2-dependent process in B cell development may represent a mechanism for IBD susceptibility...
  94. ncbi The tyrosine kinase Lyn is required for B cell development beyond the T1 stage in the spleen: rescue by over-expression of Bcl-2
    Josephine Meade
    The Laboratory of Lymphocyte Signalling and Development, Molecular Immunology Programme, The Babraham Institute, Cambridge, GB
    Eur J Immunol 32:1029-34. 2002
    ..The results indicate that Lyn plays a positive role in the selection and survival of mature B cells in addition to its previously documented negative role in tolerance and B cell activation...
  95. ncbi Recirculating and germinal center B cells differentiate into cells responsive to polysaccharide antigens
    Carola G Vinuesa
    University of Birmingham, MRC Centre for Immune Regulation, Birmingham, GB
    Eur J Immunol 33:297-305. 2003
    ..The differentiation of B cells both from germinal centers and the recirculating pool to the MZ phenotype is likely to make an important contribution to the repertoire of B cells that respond to polysaccharide antigens...
  96. ncbi Aging-dependent exclusion of antigen-inexperienced cells from the peripheral B cell repertoire
    Sara A Johnson
    Integrated Department of Immunology, University of Colorado Health Science Center and National Jewish Medical and Research Center, 1400 Jackson Street, RM K1004, Denver, CO 80206
    J Immunol 168:5014-23. 2002
    ..Beyond their importance in aging, these findings define a novel form of receptor revision in which B cells are selected rather than deleted based on Ag reactivity...
  97. ncbi Redundant role for Zap70 in B cell development and activation
    Farnaz Fallah-Arani
    Division of Immune Cell Biology, MRC National Institute for Medical Research, London, UK
    Eur J Immunol 38:1721-33. 2008
    ..However, we show that Zap70 can rescue the defective positive selection of immature B cells into the recirculating pool in Syk-deficient mice, demonstrating functional redundancy between these two kinases...
  98. ncbi Differentially regulated expression and function of CD22 in activated B-1 and B-2 lymphocytes
    Frédéric Lajaunias
    Department of Pathology, University of Geneva, Geneva, Switzerland
    J Immunol 168:6078-83. 2002
    ..These data indicate that the expression and function of CD22 are differentially regulated in B-1 and conventional B-2 cells, which are apparently implicated in innate and adaptive immunity, respectively...
  99. ncbi WY14,643, a PPAR alpha ligand, has profound effects on immune responses in vivo
    Robyn Cunard
    Research Service, Veterans Affairs San Diego Healthcare System, Department of Medicine, University of California, San Diego, CA 92161, USA
    J Immunol 169:6806-12. 2002
    ..WY14,643 in vitro induces apoptosis in lymphocytes and this effect appears to occur in a PPARalpha-independent manner. Thus WY14,643, a fibrate, is a profound immunosuppressive agent...
  100. ncbi VpreB1/VpreB2/lambda 5 triple-deficient mice show impaired B cell development but functional allelic exclusion of the IgH locus
    Takeyuki Shimizu
    Basel Institute for Immunology, Basel, Switzerland
    J Immunol 168:6286-93. 2002
    ..Surprisingly, the IgH locus was still allelically excluded and thus the SL chain appears not to be involved in allelic exclusion...
  101. ncbi Unconventional NK1.1(-) intermediate TCR cells as major T lymphocytes expanding in chronic graft-versus-host disease
    Ryoko Miyakawa
    Department of Immunology Niigata University School of Medicine, Japan
    Eur J Immunol 32:2521-31. 2002
    ..1(-) CD3(int) cells of extrathymic, hepatic origin might be crucial lymphocytes involved in the induction of the autoimmune-like disease in mice with chronic GVHD, in conjunction with Bcells (e.g. B-1 cells)...

Research Grants141 found, 100 shown here

  1. IMMUNOGLOBULIN V GENES AND B CELL DEVELOPMENT
    Richard Hardy; Fiscal Year: 2001
    ..The results of these studies will help to establish the types of selection that shape the expressed B cell repertoire, fetally and in the adult, with implications for modulating both normal and autoimmune responses. ..
  2. LY-1 B CELLS--DEVELOPMENTAL ORIGINS AND V GENE
    Richard Hardy; Fiscal Year: 2000
    ..Cumulatively, these studies will provide a clearer picture of fetal and adult B lymphopoiesis and distinguish whether the modes of selection affecting developing B cells are similar or different during these two ontogenic timi s. ..
  3. LY-1 B CELLS: DEVELOPMENTAL ORIGINS AND V GENE BIASES
    Richard Hardy; Fiscal Year: 2007
    ....
  4. LY-1 B CELLS--LINEAGE DETERMINATION/ANTIBODY REPERTOIRE
    Richard Hardy; Fiscal Year: 1992
    ..Specificities encoded by these V genes to be examined in detail will include both anti-thymocyte and anti-bromelain-treated mouse erythrocyte autoantibodies, both distinctively enriched in this population...
  5. BD Biosciences LSR Flow Cytometer
    Richard Hardy; Fiscal Year: 2002
    ..abstract_text> ..
  6. IMMUNOGLOBULIN V GENES AND B CELL DEVELOPMENT
    Richard Hardy; Fiscal Year: 2006
    ..The results of these studies will help to establish the types of selection that shape the expressed B cell repertoire, both fetally and in the adult, with implications for modulating normal and autoimmune responses. ..
  7. LY-1 B CELLS: DEVELOPMENTAL ORIGINS AND V GENE BIASES
    Richard Hardy; Fiscal Year: 2005
    ..abstract_text> ..
  8. LY-1 B CELLS: DEVELOPMENTAL ORIGINS AND V GENE BIASES
    Richard R Hardy; Fiscal Year: 2010
    ....
  9. LY-1 B-CELLS--DEVELOPMENTAL ORIGINS AND V GENE BIASES
    Richard Hardy; Fiscal Year: 1993
    ..This work may eventually help us to understand the relationship of special features of fetal B cell development with autoreactivity nd B cell neoplasia...
  10. Transitional B cell selection during peripheral B lymphopenia and reconstitution
    MICHAEL PAUL CANCRO; Fiscal Year: 2010
    ..We will assess whether reduced available BLyS levels will restore normal selective stringency by in vivo treatment with soluble TACI Ig or neutralizing anti-BLyS antibody in normal and autoimmune models. ..
  11. Transitional B cell selection during peripheral B lymphopenia and reconstitution
    MICHAEL PAUL CANCRO; Fiscal Year: 2010
    ..We will assess whether reduced available BLyS levels will restore normal selective stringency by in vivo treatment with soluble TACI Ig or neutralizing anti-BLyS antibody in normal and autoimmune models. ..
  12. ROLE OF BLYS IN PERIPHERAL B CELL SELECTION AND SURVIVAL
    Michael Cancro; Fiscal Year: 2007
    ..The resulting antisera will be assessed for broadly neutralizing activity in vitro using a well-established virus pseudotype assay. ..
  13. Aging of Early B Cell Precursors
    David Allman; Fiscal Year: 2007
    ..Together, these studies will enhance our knowledge of stem cell biology and the basis for age-related defects in early lymphocyte development. ..
  14. Immune System Development and Regulation
    Michael Cancro; Fiscal Year: 2007
    ..In this regard, the ISDR will foster research and research training that bears directly on control and manipulation of the immune system in health and disease. ..
  15. ROLE OF BLYS IN PERIPHERAL B CELL SELECTION AND SURVIVAL
    Michael Cancro; Fiscal Year: 2007
    ..A/WySnJ mice. ..
  16. Aging of Early B Cell Precursors
    David M Allman; Fiscal Year: 2010
    ..Together, these studies will enhance our knowledge of stem cell biology and the basis for age-related defects in early lymphocyte development. ..
  17. Stage-specific Signaling in Peripheral B Cell Selection
    Wasif N Khan; Fiscal Year: 2010
    ..This new knowledge can lead to the development of novel therapeutics for the treatment of B cell-mediated autoimmune diseases and immunodeficiencies and B cell lymphomas. ..
  18. MECHANISMS OF IL-2 IMMUNE ENHANCEMENT IN HUMANS
    Charlotte Cunningham Rundles; Fiscal Year: 2001
    ..Thus, this application will focus on the cellular and molecular mechanisms by which IL-2 reconstitutes T cell immunity in this model system. ..
  19. Suppression and Exacerbation of B and T cell Responses *
    Ignacio Sanz; Fiscal Year: 2007
    ..abstract_text> ..
  20. B1B lymphocytes generate T cell-independent memory
    KISHORE ALUGUPALLI; Fiscal Year: 2007
    ..Understanding the basis for the longevity of the Tl protective responses conferred by B1b cells will provide novel approaches to generate effective vaccines against pathogens expressing Tl antigens. ..
  21. Periodontal Assessment in RA Study (PARAS)
    Clifton Bingham; Fiscal Year: 2007
    ....
  22. MEDICAL SCIENTIST TRAINING PROGRAM
    TUCKER LEBIEN; Fiscal Year: 2007
    ....
  23. Primary Immune Deficiency Consortium Conference
    Charlotte Cunningham Rundles; Fiscal Year: 2007
    ..Principle topics will focus on: Diagnosis of Immunodeficiency; Genetics, Immune Reconstruction, and the Use of Standard and Novel Therapies. ..
  24. Immune control of SIVagm replication in vivo
    JOERN SCHMITZ; Fiscal Year: 2007
    ..3. Assess whether abolishing both cellular and humoral adaptive immune responses will affect the course of SIVagm infection of African green monkeys. ..
  25. Generation and maintenance of influenza-specific plasma and memory B cells
    Frances Lund; Fiscal Year: 2007
    ..The experiments in this grant will identify the ways in which B cells contribute to immunity to influenza infection and will facilitate the design of more effective vaccines to this important human disease. ..
  26. The trout kidney: major immune organ for B cell development and activation.
    Patty Zwollo; Fiscal Year: 2006
    ..As such, this study should add important knowledge in the fields of comparative and evolutionary immunology, as well as areas of autoimmune disease, including lupus and inflammatory kidney disease. ..
  27. Regulation of Humoral Immunity to Influenza Virus
    Nicole Baumgarth; Fiscal Year: 2010
    ..Completion of these studies will contribute to a better understanding of the processes that regulate the induction of protective antiviral B cell responses to influenza virus. Project Description Page 6 ..
  28. Long-lived B cell Immunity in the Respiratory Tract
    Nicole Baumgarth; Fiscal Year: 2010
    ..This basic information will provide potential avenues for rational vaccine design that aims to boost local/mucosal immune responses. ..
  29. NAD and CD38: modulators of inflammation and immunity
    Frances E Lund; Fiscal Year: 2010
    ..Thus, it is one of NIAID's highest priorities (NOT-AI-05-013) that we develop more effective influenza vaccines that are protective against a wide array of different viral serotypes. ..
  30. DIFFERENTIATIVE PROGRAMS OF LYMPHOID PROGENITOR CELLS
    TUCKER LEBIEN; Fiscal Year: 1999
    ....
  31. DIFFERENTIATIVE PROGRAMS OF LYMPHOID PROGENITOR CELLS
    TUCKER LEBIEN; Fiscal Year: 2004
    ..The collective results from these studies will enhance our understanding of the normal developmental program of human B lymphocytes and perturbations in the program that can give rise to leukemia and immunodeficiency. ..
  32. Transcription Regulation by B-Cell Receptor Signaling
    Wasif Khan; Fiscal Year: 2004
    ..Identification of these important missing links may reveal new immunotherapeutic targets for intervention in B-cell deficiency diseases such as XLA. ..
  33. ROLE FOR THE ECTOENZYME CD38 IN IMMUNE RESPONSES
    Frances Lund; Fiscal Year: 2003
    ..These experiments will provide a framework for understanding the elusive role of ecto-enzymes such as CD38 in the generation and maintenance of protective immunity. ..
  34. 2002 Summer School in Primary Immunodeficiency Disorders
    Charlotte Cunningham Rundles; Fiscal Year: 2002
    ..Fellows participating in the course will be reimbursed for their travel expenses. No registration fee will be charged for the fellows participating in the program. ..