b lymphocyte subsets

Summary

Summary: A classification of B-lymphocytes based on structurally or functionally different populations of cells.

Top Publications

  1. ncbi Chronic intestinal inflammatory condition generates IL-10-producing regulatory B cell subset characterized by CD1d upregulation
    Atsushi Mizoguchi
    Immunopathology Unit, Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA
    Immunity 16:219-30. 2002
  2. ncbi Maintenance of serological memory by polyclonal activation of human memory B cells
    Nadia L Bernasconi
    Institute for Research in Biomedicine, Via Vela 6, CH 6500 Bellinzona, Switzerland
    Science 298:2199-202. 2002
  3. ncbi B-1a and B-1b cells exhibit distinct developmental requirements and have unique functional roles in innate and adaptive immunity to S. pneumoniae
    Karen M Haas
    Department of Immunology, Box 3010, Duke University Medical Center, Durham, North Carolina 27710, USA
    Immunity 23:7-18. 2005
  4. ncbi Positive selection of natural autoreactive B cells
    K Hayakawa
    Institute for Cancer Research, Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111, USA
    Science 285:113-6. 1999
  5. ncbi B-1 cells: the lineage question revisited
    L A Herzenberg
    Department of Genetics, Stanford University School of Medicine, CA 94305, USA
    Immunol Rev 175:9-22. 2000
  6. ncbi Marginal-zone B cells
    Flavius Martin
    Department of Microbiology, University of Alabama at Birmingham, 35294 3300, USA
    Nat Rev Immunol 2:323-35. 2002
  7. ncbi An unbiased analysis of V(H)-D-J(H) sequences from B-1a, B-1b, and conventional B cells
    A B Kantor
    Department of Genetics, Stanford University Medical Center, CA 94305, USA
    J Immunol 158:1175-86. 1997
  8. ncbi The 'short' history of regulatory B cells
    Claudia Mauri
    Department of Medicine, University College London, 46 Cleveland Street, London W1T 4JF, UK
    Trends Immunol 29:34-40. 2008
  9. ncbi IL-10 regulation of lupus in the NZM2410 murine model
    Kim R M Blenman
    Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL 32601 0275, USA
    Lab Invest 86:1136-48. 2006
  10. pmc Discriminating gene expression profiles of memory B cell subpopulations
    Gotz R A Ehrhardt
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Exp Med 205:1807-17. 2008

Research Grants

  1. IMMUNOBIOLOGY OF B CELL DIFFERENTIATION
    Kenneth Dorshkind; Fiscal Year: 2007
  2. Regulation of B-Cell Apoptosis by TLR Signaling in Periodontal Disease
    Xiaozhe Han; Fiscal Year: 2012
  3. IMMUNOGLOBULIN V GENES AND B CELL DEVELOPMENT
    Richard Hardy; Fiscal Year: 2006
  4. BD Biosciences LSR Flow Cytometer
    Richard Hardy; Fiscal Year: 2002
  5. B LYMPHOCYTE GENERATION AND SELECTION IN AGED MICE
    Michael Cancro; Fiscal Year: 2003
  6. ONTOGENY OF PLASMACYTOID DENDRITIC CELLS
    David Allman; Fiscal Year: 2003
  7. Effect of aging on lymphoid stem cells
    David Allman; Fiscal Year: 2002
  8. Lymphocyte homeostastis & regulation during aging
    MICHAEL PAUL CANCRO; Fiscal Year: 2010
  9. B CELL DEFICIENCY IN A/WYSNJ MICE
    Michael Cancro; Fiscal Year: 2001
  10. ROLE OF BLYS IN PERIPHERAL B CELL SELECTION AND SURVIVAL
    Michael Cancro; Fiscal Year: 2008

Detail Information

Publications249 found, 100 shown here

  1. ncbi Chronic intestinal inflammatory condition generates IL-10-producing regulatory B cell subset characterized by CD1d upregulation
    Atsushi Mizoguchi
    Immunopathology Unit, Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA
    Immunity 16:219-30. 2002
    ..This study indicates that B cells, by producing cytokines such as IL-10, can act as regulatory cells in immunologically mediated inflammatory reactions...
  2. ncbi Maintenance of serological memory by polyclonal activation of human memory B cells
    Nadia L Bernasconi
    Institute for Research in Biomedicine, Via Vela 6, CH 6500 Bellinzona, Switzerland
    Science 298:2199-202. 2002
    ..Although antigen boosting leads to a transient increase in specific antibody levels, ongoing polyclonal activation of memory B cells offers a means to maintain serological memory for a human lifetime...
  3. ncbi B-1a and B-1b cells exhibit distinct developmental requirements and have unique functional roles in innate and adaptive immunity to S. pneumoniae
    Karen M Haas
    Department of Immunology, Box 3010, Duke University Medical Center, Durham, North Carolina 27710, USA
    Immunity 23:7-18. 2005
    ..This reciprocal contribution of B-1a and B-1b subsets to innate and acquired immunity reveals an unexpected division of labor within the B-1 compartment that is normally balanced by their coordinated development...
  4. ncbi Positive selection of natural autoreactive B cells
    K Hayakawa
    Institute for Cancer Research, Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111, USA
    Science 285:113-6. 1999
    ..Thus, B cells can be subject to positive selection, generated, and maintained on the basis of their autoreactivity...
  5. ncbi B-1 cells: the lineage question revisited
    L A Herzenberg
    Department of Genetics, Stanford University School of Medicine, CA 94305, USA
    Immunol Rev 175:9-22. 2000
    ....
  6. ncbi Marginal-zone B cells
    Flavius Martin
    Department of Microbiology, University of Alabama at Birmingham, 35294 3300, USA
    Nat Rev Immunol 2:323-35. 2002
    ..Now that the initial 'infatuation' is over, it is time to reconsider these data and generate some conclusions that can be incorporated into a working model of the B-cell system...
  7. ncbi An unbiased analysis of V(H)-D-J(H) sequences from B-1a, B-1b, and conventional B cells
    A B Kantor
    Department of Genetics, Stanford University Medical Center, CA 94305, USA
    J Immunol 158:1175-86. 1997
    ..However, characteristic differences in the repertoires of all three B cell populations also exist, suggesting different selective and/or developmental forces act to shape each repertoire...
  8. ncbi The 'short' history of regulatory B cells
    Claudia Mauri
    Department of Medicine, University College London, 46 Cleveland Street, London W1T 4JF, UK
    Trends Immunol 29:34-40. 2008
    ..The identification of their existence is of great relevance to the understanding of autoimmune diseases and to the development of new therapeutic strategies...
  9. ncbi IL-10 regulation of lupus in the NZM2410 murine model
    Kim R M Blenman
    Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL 32601 0275, USA
    Lab Invest 86:1136-48. 2006
    ..These results also reinforce the notion that IL-10 exerts multiple functions and commend caution in equating high levels of IL-10 and increased pathogenesis in systemic autoimmunity...
  10. pmc Discriminating gene expression profiles of memory B cell subpopulations
    Gotz R A Ehrhardt
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Exp Med 205:1807-17. 2008
    ....
  11. pmc Replication history of B lymphocytes reveals homeostatic proliferation and extensive antigen-induced B cell expansion
    Menno C van Zelm
    Erasmus MC, Department of Immunology, 3015 GE Rotterdam, Netherlands
    J Exp Med 204:645-55. 2007
    ..We quantified the replication history of mouse and human B lymphocyte subsets by calculating the ratio between genomic coding joints and signal joints on kappa-deleting recombination ..
  12. pmc TLR-mediated stimulation of APC: Distinct cytokine responses of B cells and dendritic cells
    Tom A Barr
    Institute of Immunology and Infection Research, School of Biological Science, University of Edinburgh, Edinburgh, UK
    Eur J Immunol 37:3040-53. 2007
    ..QRT-PCR array data indicate that this may be due to differential expression of TLR signalling molecules, effectors and adaptors. Our data highlight the potentially unique nature of immune modulation when B cells act as APC...
  13. pmc Novel human transitional B cell populations revealed by B cell depletion therapy
    Arumugam Palanichamy
    Department of Medicine, Division of Clinical Immunology and Rheumatology, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Immunol 182:5982-93. 2009
    ..The characterization of multiple transitional B cell subpopulations provides important insights into human B cell development...
  14. ncbi An essential role for BAFF in the normal development of B cells through a BCMA-independent pathway
    B Schiemann
    Biogen, 14 Cambridge Center, Cambridge, MA 02142, USA
    Science 293:2111-4. 2001
    ..In contrast, mice lacking BCMA had normal-appearing B lymphocyte compartments. BAFF therefore plays a crucial role in B cell development and can function through receptors other than BCMA...
  15. ncbi Impairment of T-cell-dependent B-cell responses and B-1 cell development in CD19-deficient mice
    R C Rickert
    Institute for Genetics, University of Cologne, Germany
    Nature 376:352-5. 1995
    ..2)...
  16. ncbi B cells activated by lipopolysaccharide, but not by anti-Ig and anti-CD40 antibody, induce anergy in CD8+ T cells: role of TGF-beta 1
    Vrajesh V Parekh
    National Center for Cell Science, Pune, Maharashtra, India School of Biotechnology, Devi Ahilya Vishwavidyalaya, Indore, Madhya Pradesh, India
    J Immunol 170:5897-911. 2003
    ..Therefore, this study, for the first time, provides a novel mechanism of B cell surface TGF-beta1-mediated hyporesponsiveness leading to anergy of CD8(+) T cells...
  17. ncbi Development of B cells producing natural autoantibodies to thymocytes and senescent erythrocytes
    Richard R Hardy
    Division of Basic Sciences, Fox Chase Cancer Center, 333 Cottman Ave, Philadelphia, PA 19111, USA
    Springer Semin Immunopathol 26:363-75. 2005
    ....
  18. ncbi CpG drives human transitional B cells to terminal differentiation and production of natural antibodies
    Federica Capolunghi
    Laboratory of B cell Development Research Center, Department of Medical and Surgical Neonatology, Children Hospital Bambino Gesù, and Department of Clinical Medicine, University of Rome La Sapienza, Italy
    J Immunol 180:800-8. 2008
    ..Therefore, the ability of transitional B cells to sense bacterial DNA through TLR9 represents a tool to rapidly build up the repertoire of natural Abs necessary for our first-line defense at birth...
  19. ncbi Enumeration and characterization of virus-specific B cells by multicolor flow cytometry
    Virginia P Doucett
    Center for Comparative Medicine, University of California, Davis, County Rd 98, CA 95616, USA
    J Immunol Methods 303:40-52. 2005
    ..We conclude that viral HA can be used in conjunction with cell surface and intracytoplasmic stains in multicolor flow cytometry to provide detailed phenotypic and functional information on virus HA-specific B cells...
  20. ncbi Cutting edge: BLyS enables survival of transitional and mature B cells through distinct mediators
    Benjamin L Hsu
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Immunol 168:5993-6. 2002
    ....
  21. ncbi B cell development pathways
    R R Hardy
    Institute for Cancer Research, Fox Chase Cancer Center, 7701 Burholme Ave, Philadelphia, Pennsylvania 19111, USA
    Annu Rev Immunol 19:595-621. 2001
    ....
  22. ncbi B cell-specific deletion of protein-tyrosine phosphatase Shp1 promotes B-1a cell development and causes systemic autoimmunity
    Lily I Pao
    Cancer Biology Program, Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
    Immunity 27:35-48. 2007
    ..Thus, Shp1 deficiency in B cells alone perturbs B cell development and causes autoimmune disease...
  23. ncbi Differential effects of epratuzumab on peripheral blood B cells of patients with systemic lupus erythematosus versus normal controls
    A M Jacobi
    Charite Centrum 12, Charite University Medicine, Berlin, Germany
    Ann Rheum Dis 67:450-7. 2008
    ..Epratuzumab, a humanised anti-CD22 monoclonal antibody, is currently in clinical trials, although its effects on patients' B cells are not completely understood...
  24. pmc Phenotypic and functional heterogeneity of human memory B cells
    Inaki Sanz
    Division of Allergy, Immunology and Rheumatology, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Semin Immunol 20:67-82. 2008
    ....
  25. pmc The CD19 signal transduction molecule is a response regulator of B-lymphocyte differentiation
    S Sato
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 92:11558-62. 1995
    ....
  26. pmc B lymphocytes: how they develop and function
    Tucker W Lebien
    Department of Laboratory Medicine Pathology, University of Minnesota Cancer Center, Minneapolis, MN 55455, USA
    Blood 112:1570-80. 2008
    ..Despite the significant advances that have been made at the cellular and molecular levels, there is much more to learn, and cross-disciplinary studies in hematology and immunology will continue to pave the way for new discoveries...
  27. ncbi Ig gene rearrangement steps are initiated in early human precursor B cell subsets and correlate with specific transcription factor expression
    Menno C van Zelm
    Department of Immunology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
    J Immunol 175:5912-22. 2005
    ....
  28. ncbi Latent membrane protein 2A, a viral B cell receptor homologue, induces CD5+ B-1 cell development
    Akiko Ikeda
    Department of Microbiology Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    J Immunol 172:5329-37. 2004
    ..Furthermore, these studies offer insight into EBV latency and pathogenesis in the human host...
  29. ncbi CD38 low IgG-secreting cells are precursors of various CD38 high-expressing plasma cell populations
    Sergio Arce
    Deutsches Rheuma ForschungsZentrum Berlin, Schumannstrasse 20 21, D 10117 Berlin, Germany
    J Leukoc Biol 75:1022-8. 2004
    ..These data are compatible with a multistep model for plasma cell differentiation and imply that a common CD38 low IgG-secreting precursor gives rise to a diverse plasma cell compartment...
  30. ncbi Association of B-1 B cells with follicular dendritic cells in spleen
    Lijun Wen
    Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    J Immunol 174:6918-26. 2005
    ..These results indicate that B-1 B cells are the first B cells to express fully mature levels of CXCR5, thereby promoting the development of FDC...
  31. ncbi Innate-like B cells
    John F Kearney
    Division of Developmental and Clinical Immunology, Department of Microbiology, University of Alabama at Birmingham, WTI 378, 1824 6th Avenue South, Birmingham, AL 35294 3300, USA
    Springer Semin Immunopathol 26:377-83. 2005
    ..These innate-like B cell subsets form a bridge between the rapidly occurring innate immune responses, and the slower acting primary, T cell-dependent, adaptive antibody response by providing a rapid T cell-independent antibody response...
  32. ncbi Expression of CD80/86 on B cells is essential for autoreactive T cell activation and the development of arthritis
    Shannon K O'Neill
    Department of Immunology Microbiology, Rush University, Medical Center, Chicago, IL 60612, USA
    J Immunol 179:5109-16. 2007
    ..These results demonstrate that a CD80/86:CD28 costimulatory interaction between B cells and T cells is required for autoreactive T cell activation and the induction of arthritis but not for B cell autoantibody production...
  33. ncbi Regulatory role of B-1 B cells in chronic colitis
    Yasuyo Shimomura
    Experimental Pathology, Massachusetts General Hospital, Boston, MA 02114, USA
    Int Immunol 20:729-37. 2008
    ..We conclude that B-1 cells play a regulatory role in T(h)2-mediated colitis under non-hygienic conditions, possibly by generating natural antibodies in response to microbial flora...
  34. pmc B cells in Sjögren's syndrome: indications for disturbed selection and differentiation in ectopic lymphoid tissue
    Arne Hansen
    Charite Center CC 12, Department of Medicine, Charite Universitatsmedizin Berlin, Charité Platz 01, 10098 Berlin, Germany
    Arthritis Res Ther 9:218. 2007
    ..These findings add to our understanding of the pathogenesis of this autoimmune inflammatory disorder and may result in new therapeutic approaches...
  35. ncbi Identification and characterization of a human CD5+ pre-naive B cell population
    Jisoo Lee
    Department of Internal Medicine, Ewha Womans University School of Medicine, Seoul, Korea
    J Immunol 182:4116-26. 2009
    ..These results have identified a unique intermediate in human naive B cell development within the peripheral blood and derangements of its homeostasis in patients with systemic lupus erythematosus...
  36. ncbi B lymphocyte depletion by CD20 monoclonal antibody prevents diabetes in nonobese diabetic mice despite isotype-specific differences in Fc gamma R effector functions
    Yan Xiu
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 180:2863-75. 2008
    ..Moreover, this study defines a new, clinically relevant approach whereby B cell depletion early in the course of disease development may prevent diabetes or delay progression of disease...
  37. pmc Somatic diversification in the absence of antigen-driven responses is the hallmark of the IgM+ IgD+ CD27+ B cell repertoire in infants
    Sandra Weller
    Institut National de la Santé et de la Recherche Médicale U783, Développement du Système Immunitaire, Universite Paris Descartes, Faculte de Medecine, Site Necker Enfants Malades, Paris 75015, France
    J Exp Med 205:1331-42. 2008
    ..These data provide evidence for the developmental diversification of IgM(+)IgD(+)CD27(+) B cells, at least in very young children, outside of T cell-dependent and -independent immune responses...
  38. pmc B cell development in the spleen takes place in discrete steps and is determined by the quality of B cell receptor-derived signals
    F Loder
    Department of Molecular Immunology, University of Freiburg, Germany
    J Exp Med 190:75-89. 1999
    ....
  39. ncbi Expansion of functionally immature transitional B cells is associated with human-immunodeficient states characterized by impaired humoral immunity
    Amanda K Cuss
    Centenary Institute of Cancer Medicine and Cell Biology, New South Wales, Australia
    J Immunol 176:1506-16. 2006
    ..Further investigation of transitional B cells will improve our understanding of human B cell development and how alterations to this process may precipitate immunodeficiency or autoimmunity...
  40. ncbi Regulatory B cells as inhibitors of immune responses and inflammation
    Jean David Bouaziz
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    Immunol Rev 224:201-14. 2008
    ..This review focuses on the recent progress in this field and the exciting opportunities for understanding how this unique B-cell subset influences diverse immune functions...
  41. pmc Toll-like receptor expression and responsiveness of distinct murine splenic and mucosal B-cell subsets
    Murali Gururajan
    Vaccine Research Center, Emory University, Atlanta, Georgia, United States of America
    PLoS ONE 2:e863. 2007
    ..Furthermore, the expression and functional relevance of TLRs on distinct subsets of B cells, which are known to play differential roles in humoral responses is not known...
  42. ncbi Resolution of three nonproliferative immature splenic B cell subsets reveals multiple selection points during peripheral B cell maturation
    D Allman
    Department of Pathology and Laboratory Medicine and Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Immunol 167:6834-40. 2001
    ....
  43. ncbi Regulatory mechanisms that determine the development and function of plasma cells
    Kathryn L Calame
    Department of Microbiology and Biochemistry, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Annu Rev Immunol 21:205-30. 2003
    ..Thus, commitment to plasmacytic differentiation involves inhibition of activities associated with earlier B cell developmental stages as well as expression of the plasma cell phenotype...
  44. ncbi Protein tyrosine phosphatase 1C negatively regulates antigen receptor signaling in B lymphocytes and determines thresholds for negative selection
    J G Cyster
    Department of Microbiology and Immunology, Beckman Center, Stanford University School of Medicine, California 94305, USA
    Immunity 2:13-24. 1995
    ..These findings establish that activation of distinct repertoire-censoring mechanisms depends on quantitative differences in antigen receptor signaling, whose thresholds are determined by negative regulation through PTP1C...
  45. ncbi Critical roles for Rac1 and Rac2 GTPases in B cell development and signaling
    Marita J Walmsley
    Division of Immune Cell Biology, National Institute for Medical Research, The Ridgeway, Mill Hill, London, NW7 1AA, UK
    Science 302:459-62. 2003
    ..Both GTPases were required to transduce BCR signals leading to proliferation, survival and up-regulation of BAFF-R, a receptor for BAFF, a key survival molecule required for B cell development and maintenance...
  46. ncbi B-cell commitment, development and selection
    R R Hardy
    Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Immunol Rev 175:23-32. 2000
    ..Finally, we describe a new VH3609 antithymocyte Ig transgenic mouse model system that has provided the first definitive evidence for the role of self-antigen in development and maintenance of natural autoreactive B cells...
  47. ncbi Helicobacter pylori vacuolating cytotoxin inhibits activation-induced proliferation of human T and B lymphocyte subsets
    Victor J Torres
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232 2605, USA
    J Immunol 179:5433-40. 2007
    ..We propose that the immunomodulatory actions of VacA on T and B lymphocytes, the major effectors of the adaptive immune response, may contribute to the ability of H. pylori to establish a persistent infection in the human gastric mucosa...
  48. ncbi Correlation between circulating CD27high plasma cells and disease activity in patients with systemic lupus erythematosus
    Annett M Jacobi
    University Hospital Charite, Berlin, Germany
    Arthritis Rheum 48:1332-42. 2003
    ..In order to determine whether SLE disease activity correlates with abnormal B lymphocyte activity, B cell subsets were analyzed, and their relationship to clinical and humoral measures of disease activity was assessed...
  49. pmc Follicular lymphoma-like B cells in healthy individuals: a novel intermediate step in early lymphomagenesis
    Sandrine Roulland
    Centre d immunologie de Marseille Luminy, Universite de la Mediterranee, 13288 Marseille, France
    J Exp Med 203:2425-31. 2006
    ..These findings strongly impact both on the current understanding of disease progression and on the proper handling of t(14;18) frequency in blood as a potential early biomarker for lymphoma...
  50. ncbi The human immunomodulatory CD25+ B cell population belongs to the memory B cell pool
    S Amu
    Department of Rheumatology and Inflammation Research, Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    Scand J Immunol 66:77-86. 2007
    ..In conclusion, CD20(+)25(+) B cells constitute a unique subpopulation preferentially occurring among CD20(+)27(+) memory B cells. We suggest that CD25 can be used as a marker for a memory B cell subset...
  51. ncbi From the fetal liver to spleen and gut: the highway to natural antibody
    M M Rosado
    Research Center, Ospedale Pediatrico Bambino Gesu, IRCCS, Roma, Italy
    Mucosal Immunol 2:351-61. 2009
    ..The natural antibodies in the serum and on the intestinal epithelium may be an evolutionary ancient tool for the immediate protection against commensal and pathogenic bacteria...
  52. ncbi B cells acquire particulate antigen in a macrophage-rich area at the boundary between the follicle and the subcapsular sinus of the lymph node
    Yolanda R Carrasco
    Lymphocyte Interaction Laboratory, Cancer Research United Kingdom London Research Institute, Lincoln s Inn Fields Laboratories, 44 Lincoln s Inn Fields, London WC2A 3PX, United Kingdom
    Immunity 27:160-71. 2007
    ..These observations not only provide evidence of a B cell role as antigen transporters into the follicle, but also highlight the boundary between the follicle and the SCS as a site for initiation of B cell responses...
  53. pmc Absolute count of T and B lymphocyte subsets is decreased in systemic sclerosis
    Thilo Gambichler
    Department of Dermatology, Ruhr University Bochum, 44791 Bochum, Germany
    Eur J Med Res 15:44-6. 2010
    ..Previous reports on lymphocyte subpopulations in systemic sclerosis (SSc) are conflicting. Therefore, we aimed to investigate the lymphocyte subsets in SSc patients who were not on immunosuppressive therapy...
  54. ncbi Divide and conquer: division of labor by B-1 B cells
    Kishore R Alugupalli
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, Massachusetts 01655, USA
    Immunity 23:1-2. 2005
    ....
  55. ncbi A case for regulatory B cells
    Atsushi Mizoguchi
    Immunopathology Unit, Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Immunol 176:705-10. 2006
    ..In this review, we make a case for the existence of regulatory B cells and discuss the possible developmental pathways and functional mechanisms of these B cells...
  56. ncbi The dendritic cell-specific CC-chemokine DC-CK1 is expressed by germinal center dendritic cells and attracts CD38-negative mantle zone B lymphocytes
    E Lindhout
    Department of Tumor Immunology, University Medical Center, Nijmegen, The Netherlands
    J Immunol 166:3284-9. 2001
    ..The findings that GCDC produce DC-CK1 and attract mantle zone B cells support a key role for GCDC in the development of GCs and memory B cell formation...
  57. ncbi Immunohistochemistry of the B-cell component in lower lip salivary glands of Sjögren's syndrome and healthy subjects
    A Larsson
    Department of Oral Pathology, Centre for Oral Health Sciences, Malmo University, Malmo, Sweden
    Scand J Immunol 61:98-107. 2005
    ..Further, the findings suggest that the early immigrating lymphocytes may have been primed at a site remote from the glands before arriving via the blood to the gland tissue...
  58. pmc Homeostatic control of B lymphocyte subsets
    Jenni E Crowley
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 284 John Morgan Building 36th and Hamilton Walk, Philadelphia, PA, 19104 6082, USA
    Immunol Res 42:75-83. 2008
    ..A refined understanding of these relationships should yield insight into the selection and maintenance of B cell subsets, as well as an appreciation of how homeostatic mechanisms may contribute to immunosenescence...
  59. ncbi Targeted disruption of the p50 subunit of NF-kappa B leads to multifocal defects in immune responses
    W C Sha
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139
    Cell 80:321-30. 1995
    ..These data support the role of NF-kappa B as a vital transcription factor for both specific and nonspecific immune responses, but do not indicate a developmental role for the factor...
  60. ncbi Distinct and overlapping roles of CXCR5 and CCR7 in B-1 cell homing and early immunity against bacterial pathogens
    Uta E Höpken
    Department of Tumor Genetics and Immunogenetics, MDC, Robert Rossle Str 10, 13092 Berlin, Germany
    J Leukoc Biol 76:709-18. 2004
    ..CXCR5 plays a dominant role in peritoneal B-1 B cell homing and body cavity immunity, but both chemokine receptors are needed for a proportional peritoneal B-2 cell homing and balanced development of an early splenic B cell response...
  61. ncbi NF-kappa B1 p50 is required for BLyS attenuation of apoptosis but dispensable for processing of NF-kappa B2 p100 to p52 in quiescent mature B cells
    Eunice N Hatada
    Department of Pathology, Cornell Rockefeller University Sloan Kettering Institute Tri Institutional MD PhD Program, Weill Medical College of Cornell University, New York, NY, 10021, USA
    J Immunol 171:761-8. 2003
    ..These results suggest that BLyS mediates its survival signals in metabolically restricted quiescent B cells, at least in part, through coordinated activation of both NF-kappaB pathways and selective downstream antiapoptotic genes...
  62. ncbi Commitment of B lymphocytes to a plasma cell fate is associated with Blimp-1 expression in vivo
    C Angelin-Duclos
    Departments of Microbiology and Pathology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    J Immunol 165:5462-71. 2000
    ..Together, these data support a model in which B cell fate decisions occur within the germinal center and Blimp-1 expression is critical for commitment to a plasma cell, rather than a memory cell, fate...
  63. ncbi Generation of migratory antigen-specific plasma blasts and mobilization of resident plasma cells in a secondary immune response
    Marcus Odendahl
    Department of Medicine, Charite, Humbold University, D 10117 Berlin, Germany
    Blood 105:1614-21. 2005
    ....
  64. ncbi Defective development and function of Bcl10-deficient follicular, marginal zone and B1 B cells
    Liquan Xue
    Department of Pathology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Nat Immunol 4:857-65. 2003
    ..Thus, Bcl10 is essential for the development of all mature B cell subsets...
  65. ncbi Chemotaxis of human tonsil B lymphocytes to CC chemokine receptor (CCR) 1, CCR2 and CCR4 ligands is restricted to non-germinal center cells
    Anna Corcione
    Laboratory of Oncology, G Gaslini Institute, Largo G Gaslini 5, 16148 Genova, Italy
    Int Immunol 14:883-92. 2002
    ..CCR1, CCR2 and CCR4 were detected by flow cytometry on non-GC (i.e. naive and memory) B cells, whereas they were absent (CCR1 and CCR2) or poorly expressed (CCR4) on GC B cells...
  66. ncbi Autoreactivity by design: innate B and T lymphocytes
    A Bendelac
    Department of Molecular Biology, Princeton University, New Jersey 08544, USA
    Nat Rev Immunol 1:177-86. 2001
    ..New studies have shed light on the principles and mechanisms that drive their unique development and function, and show their resemblance to another subset of innate lymphocytes, the natural killer cells...
  67. ncbi DNA fiber fluorescence in situ hybridization analysis of immunoglobulin class switching in B-cell neoplasia: aberrant CH gene rearrangements in follicle center-cell lymphoma
    J W Vaandrager
    Department of Pathology, Hematology, Cytometry and Cytochemistry, Leiden University Medical Centre, Leiden, The Netherlands
    Blood 92:2871-8. 1998
    ..Fiber FISH analysis also showed several polymorphisms. The most frequent one, present on 38% of all analyzed alleles, consisted of an extra Cgamma gene or pseudogene in the 3' cluster...
  68. ncbi Regulation and function of cyclin D2 in B lymphocyte subsets
    Thomas C Chiles
    Department of Biology, Boston College, Chestnut Hill, MA 02467, USA
    J Immunol 173:2901-7. 2004
    ..This review focuses on recent progress toward understanding the function of cyclin D2 in cell cycle control, and in the development of murine B lymphocytes...
  69. ncbi Germinal centers regulate human Th2 development
    Bengt Johansson-Lindbom
    Department of Immunotechnology, Lund University, Lund, Sweden
    J Immunol 171:1657-66. 2003
    ....
  70. pmc A distinct Toll-like receptor repertoire in human tonsillar B cells, directly activated by PamCSK, R-837 and CpG-2006 stimulation
    Anne Mansson
    Laboratory of Clinical and Experimental Allergy Research, Department of Otorhinolaryngology, Malmo University Hospital, Lund University, Sweden
    Immunology 118:539-48. 2006
    ..Furthermore, the distinct expression of TLRs allows B cells to respond directly to the cognate PAMPs. This further emphasizes the role of TLRs in directly activating adaptive immune cells...
  71. ncbi Origins and functions of B-1 cells with notes on the role of CD5
    Robert Berland
    Department of Pathology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    Annu Rev Immunol 20:253-300. 2002
    ..The CD5 molecule can function as a negative regulator of BCR signaling that may help prevent inappropriate activation of autoreactive B-1a cells...
  72. ncbi Categorical selection of the antibody repertoire in splenic B cells
    Robert L Schelonka
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35233 1530, USA
    Eur J Immunol 37:1010-21. 2007
    ....
  73. ncbi Fas is required for clonal selection in germinal centers and the subsequent establishment of the memory B cell repertoire
    Y Takahashi
    Department of Immunology, National Institute of Infectious Diseases, 1 23 1 Toyama, Shinjuku ku, 162 8640, Tokyo, Japan
    Immunity 14:181-92. 2001
    ..These results suggest that Fas is required for clonal selection within GCs and the establishment of the memory B cell repertoire...
  74. ncbi Peripheral development of B cells in mouse and man
    Rita Carsetti
    Research Center Ospedale Bambino Gesù, Roma, Italy
    Immunol Rev 197:179-91. 2004
    ..B-1a and IgM memory B cells may function as a link between the innate and adaptive immune response and thus perform a primordial B-cell function...
  75. ncbi Marginal zone B cells
    Shiv Pillai
    Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02129, USA
    Annu Rev Immunol 23:161-96. 2005
    ..Here, we discuss the functions of these cells in both innate and adaptive immunity. We also attempt to reconcile differing viewpoints regarding the generation and function of marginal zone B cells in rodents and primates...
  76. ncbi Activated memory B cell subsets correlate with disease activity in systemic lupus erythematosus: delineation by expression of CD27, IgD, and CD95
    Annett M Jacobi
    Charite Universitatsmedizin Berlin, Berlin, Germany
    Arthritis Rheum 58:1762-73. 2008
    ..Focusing on CD27- B cells, this study aimed to identify abnormalities in peripheral B cell subsets in patients with SLE...
  77. pmc Expression of the immunoregulatory molecule FcRH4 defines a distinctive tissue-based population of memory B cells
    Gotz R A Ehrhardt
    Division of Clinical and Developmental Immunology, University of Alabama at Birmingham, Birmingham, Birmingham, AL 35294, USA
    J Exp Med 202:783-91. 2005
    ..Cell surface FcRH4 expression thus marks a unique population of memory B cells with distinctive morphology, functional capabilities, and tissue localization...
  78. pmc HIV-1 induces phenotypic and functional perturbations of B cells in chronically infected individuals
    S Moir
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, and Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 98:10362-7. 2001
    ..These results indicate that HIV viremia induces the appearance of a subset of B cells whose function is impaired and which may be responsible for the hypergammaglobulinemia associated with HIV disease...
  79. ncbi Distinct signaling mechanisms activate the target of rapamycin in response to different B-cell stimuli
    Amber C Donahue
    Department of Molecular Biology and Biochemistry, and Center for Immunology, University of California Irvine, Irvine, CA 92697 3900, USA
    Eur J Immunol 37:2923-36. 2007
    ..These data define both similarities and differences in PI3K/mTOR signaling mechanisms in MZ and FO cells, and suggest that mTOR signaling can occur in the absence of PI3K activation to promote B cell responses to LPS...
  80. ncbi IgA and IgM V(H) repertoires in human colon: evidence for clonally expanded B cells that are widely disseminated
    W Holtmeier
    Medizinische Klinik II, Johann Wolfgang Goethe Universitdt, Frankfurt am Main, Germany
    Gastroenterology 119:1253-66. 2000
    ..Because lamina propria B cells should reflect the antigenic experience of the gut, we investigated their immunoglobulin (Ig) repertoire and distribution...
  81. ncbi B1 cells: similarities and differences with other B cell subsets
    F Martin
    Division of Developmental and Clinical Immunology, Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294-3300, USA
    Curr Opin Immunol 13:195-201. 2001
    ..Most advances have been made in describing the physiological activities of B1 cells, including their migration, activation by antigen and role in both autoimmunity and malignancy...
  82. ncbi Impact of the BAFF/BR3 axis on B cell survival, germinal center maintenance and antibody production
    Susan L Kalled
    Biogen Idec, Inc, 12 Cambridge Center, Cambridge, MA 02142, USA
    Semin Immunol 18:290-6. 2006
    ..These include germinal center maintenance, isotype switching, and regulation of specific B cell surface markers. More importantly, a role for BAFF in B cell biology has been validated in vivo in humans...
  83. ncbi Signaling via LTbetaR on the lamina propria stromal cells of the gut is required for IgA production
    Hyung Sik Kang
    Department of Pathology and Committee on Immunology, The University of Chicago, 5841 S Maryland, Chicago, IL 60637, USA
    Nat Immunol 3:576-82. 2002
    ....
  84. ncbi CD1 expression defines subsets of follicular and marginal zone B cells in the spleen: beta 2-microglobulin-dependent and independent forms
    M Amano
    Department of Medicine, Stanford University School of Medicine, CA 94305 5111, USA
    J Immunol 161:1710-7. 1998
    ..They further suggest that a beta 2m-independent form of CD1 is expressed on B cells that can stimulate T cells; however, this form is not easily visualized with the anti-CD1 mAb used here...
  85. ncbi TLR agonists selectively promote terminal plasma cell differentiation of B cell subsets specialized in thymus-independent responses
    Laurent Genestier
    Institut National de la Santé et de la Recherche Médicale Unité 851, IFR128 Biosciences Lyon Gerland, 21 Avenue Tony Garnier, Lyon, France
    J Immunol 178:7779-86. 2007
    ....
  86. ncbi Cutting edge commentary: origins of B-1 cells
    H H Wortis
    Department of Pathology, Tufts University School of Medicine and Program in Immunology, Sackler School of Graduate Biomedical Sciences, Boston MA 02111, USA
    J Immunol 166:2163-6. 2001
    ..CD5 expression and possibly localization to the peritoneum appear to provide some protection to autoreactive cells otherwise slated for elimination...
  87. ncbi The effect of combination antiretroviral therapy on CD5 B- cells, B-cell activation and hypergammaglobulinaemia in HIV-1-infected patients
    B E Redgrave
    School of Surgery and Pathology, University of Western Australia, Perth, Western Australia, Australia
    HIV Med 6:307-12. 2005
    ..This study assessed B-cell activation, CD5 B-cells and circulating immunoglobulin levels in HIV-infected patients treated with combination antiretroviral therapy (CART)...
  88. ncbi Disturbed peripheral B lymphocyte homeostasis in systemic lupus erythematosus
    M Odendahl
    Deutsches Rheuma ForschungsZentrum Berlin, Charite University Hospital, Berlin, Germany
    J Immunol 165:5970-9. 2000
    ..These results indicate that there are profound abnormalities in the various B cell compartments in SLE that respond differently to immunosuppressive therapy...
  89. ncbi Direct impact of inactivated HIV-1 virions on B lymphocyte subsets
    Muriel Viau
    INSERM U430, Paris, France
    Mol Immunol 44:2124-34. 2007
    ..Because there is evidence that human IgM memory B cells are functionally equivalent to murine B-1a cells, our findings suggest that gp120 may have a direct deleting activity on B cell memory...
  90. ncbi Mouse CD38 is down-regulated on germinal center B cells and mature plasma cells
    A M Oliver
    Division of Developmental and Clinical Immunology, Department of Microbiology, University of Alabama at Birmingham 35294, USA
    J Immunol 158:1108-15. 1997
    ..These results are in contrast to studies in humans in which CD38 is not found on follicular B cells but is highly expressed on germinal center B cells and plasma cells...
  91. ncbi Transitional type 1 and 2 B lymphocyte subsets are differentially responsive to antigen receptor signaling
    James B Petro
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0146, USA
    J Biol Chem 277:48009-19. 2002
    ..In turn, these signaling pathways probably govern the development and selection processes that are critical for the formation of the mature B cell compartment...
  92. ncbi deltaBAFF, a splice isoform of BAFF, opposes full-length BAFF activity in vivo in transgenic mouse models
    Amanda L Gavin
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunol 175:319-28. 2005
    ..In contrast, BAFF transgenic mice had extraordinarily elevated Ig levels and increases in subsets of B cells. Unexpectedly, both BAFF and DeltaBAFF appeared to modulate the numbers of B-1 phenotype B cells...
  93. pmc Is the blood B-cell subset profile diagnostic for Sjogren syndrome?
    A Binard
    EA Immunologie et Pathologie, Universite Europeenne de Bretagne, et Université de Bretagne Occidentale, Brest, et Centre Hospitalier Universitaire de Brest, Brest F29609, France
    Ann Rheum Dis 68:1447-52. 2009
    ..To evaluate the relevance of the blood B-cell subset profile for the diagnosis of Sjögren syndrome...
  94. ncbi Regulation of BCR signal transduction in B-1 cells requires the expression of the Src family kinase Lck
    Joseph M Dal Porto
    Integrated Department of Immunology, National Jewish Medical and Research Center, University of Colorado School of Medicine, Denver 80206, USA
    Immunity 21:443-53. 2004
    ..Interestingly, lck-null mice exhibited increased natural antibody levels characteristic of B-1 cells. Taken together, these results demonstrate a key role for Lck in modulating the signaling and cellular fate of B-1 B cells...
  95. ncbi Depletion of B cells by a humanized anti-CD20 antibody PRO70769 in Macaca fascicularis
    Yulia Vugmeyster
    Genentech, Inc, South San Francisco, California 94080, USA
    J Immunother 28:212-9. 2005
    ..After recovery, B-cell subsets were reconstituted to normal levels. Depletion of CD20-expressing cells and lymphoid follicular atrophy were the only treatment-related effects...
  96. ncbi Activation of marginal zone B cells from lupus mice with type A(D) CpG-oligodeoxynucleotides
    Rachel Brummel
    Division of Rheumatology, Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    J Immunol 174:2429-34. 2005
    ..Through increased IL-10 secretion, MZ-B cells may also modify the activity of other cell types, particularly dendritic cells and macrophages...
  97. pmc Recapitulation of B cell differentiation in the central nervous system of patients with multiple sclerosis
    Anna Corcione
    Laboratory of Oncology, Scientific Direction, G Gaslini Institute, 16148 Genoa, Italy
    Proc Natl Acad Sci U S A 101:11064-9. 2004
    ..The presence of lymphotoxin-alpha, CXCL12, and CXCL13 in the CNS may provide favorable microenvironmental conditions for these events...
  98. ncbi Uncoupling of anergy from developmental arrest in anti-insulin B cells supports the development of autoimmune diabetes
    Carlos A Acevedo-Suárez
    Department of Medicine, Vanderbilt University, Nashville, TN 37232, USA
    J Immunol 174:827-33. 2005
    ..These findings suggest that the degree of functional impairment, rather than an overt breach of tolerance, is a critical feature that governs B cell contribution to T cell-mediated autoimmune disease...
  99. ncbi Identification of transitional type II B cells in the salivary glands of patients with Sjögren's syndrome
    Capucine Daridon
    Laboratory of Immunology, Brest University Medical School Hospital, BP824, F 29609 Brest, France
    Arthritis Rheum 54:2280-8. 2006
    ..A special emphasis was placed on those B lymphocytes included in the ectopic germinal centers (GCs)...
  100. ncbi TNF deficiency fails to protect BAFF transgenic mice against autoimmunity and reveals a predisposition to B cell lymphoma
    Marcel Batten
    Department of Arthritis and Inflammation, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, New South Wales 2010, Australia
    J Immunol 172:812-22. 2004
    ....
  101. ncbi CD27 expression by a distinct subpopulation of human B lymphocytes
    D Maurer
    Institute of Immunology, Vienna International Research Cooperation Center, Austria
    Eur J Immunol 20:2679-84. 1990
    ..These latter findings suggest that CD27+ B cells are predispose to form cell-cell interactions. Accordingly, within 3 h of cell culture CD27+, but not CD27-, B lymphocytes were found to form LFA-1-mediated homotypic B cell clusters...

Research Grants71

  1. IMMUNOBIOLOGY OF B CELL DIFFERENTIATION
    Kenneth Dorshkind; Fiscal Year: 2007
    ..The data also have implications for understanding the origin of tumors with B/macrophage characteristics. ..
  2. Regulation of B-Cell Apoptosis by TLR Signaling in Periodontal Disease
    Xiaozhe Han; Fiscal Year: 2012
    ..While various B lymphocyte subsets express multiple TLRs, including TLR4 and TLR9, the role of TLR signaling on B cell apoptosis is entirely ..
  3. IMMUNOGLOBULIN V GENES AND B CELL DEVELOPMENT
    Richard Hardy; Fiscal Year: 2006
    ..The results of these studies will help to establish the types of selection that shape the expressed B cell repertoire, both fetally and in the adult, with implications for modulating normal and autoimmune responses. ..
  4. BD Biosciences LSR Flow Cytometer
    Richard Hardy; Fiscal Year: 2002
    ..abstract_text> ..
  5. B LYMPHOCYTE GENERATION AND SELECTION IN AGED MICE
    Michael Cancro; Fiscal Year: 2003
    ..In the fourth aim, the life span, homing characteristics, and repertoire diversity of recirculating mature B-cells in aged marrow will be determined, to assess the identity and functional significance of this population. ..
  6. ONTOGENY OF PLASMACYTOID DENDRITIC CELLS
    David Allman; Fiscal Year: 2003
    ..abstract_text> ..
  7. Effect of aging on lymphoid stem cells
    David Allman; Fiscal Year: 2002
    ..In Aim 3, we will establish BM chimeras to determine whether age-associated decreases in frequencies of CLPs reflect cell autonomous versus environmental defects. ..
  8. Lymphocyte homeostastis & regulation during aging
    MICHAEL PAUL CANCRO; Fiscal Year: 2010
    ..abstract_text> ..
  9. B CELL DEFICIENCY IN A/WYSNJ MICE
    Michael Cancro; Fiscal Year: 2001
    ....
  10. ROLE OF BLYS IN PERIPHERAL B CELL SELECTION AND SURVIVAL
    Michael Cancro; Fiscal Year: 2008
    ..A/WySnJ mice. ..
  11. Development of plasmacytoid dendritic cells
    David Allman; Fiscal Year: 2008
    ..Determine the actual contribution of Rag-2+ lymphoid progenitors to each peripheral DC subset including PDCs; and 3. Identify cytokines that can redirect early B cell progenitors into the DC lineage in vitro and in vivo. ..
  12. Aging of Early B Cell Precursors
    David M Allman; Fiscal Year: 2010
    ..Together, these studies will enhance our knowledge of stem cell biology and the basis for age-related defects in early lymphocyte development. ..
  13. Study of Human B-cell Tolerance by Functional Genomics
    Ignacio Sanz; Fiscal Year: 2005
    ..In addition, although the questions asked are hypothesis-driven, the approach proposed is highly exploratory and, as such, is responsive to this RFA. ..
  14. Co-stimuli for Human Marginal Zone B Cell Activation
    Patricia Mongini; Fiscal Year: 2004
    ..Such insights should suggest immunologic intervention therapies for blocking the activation of autoreactive B cells in SLE. ..
  15. BLyS and IFN responses to antigen challenge in human SLE
    W Chatham; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  16. UAB SIG Supporting Flow Cytometry & High Speed Cell Sorting
    Robert Carter; Fiscal Year: 2006
    ..Combined with efforts by the Facility in investigator education and outreach, this proposal will significantly improve the flow cytometry services in support of NIH funded projects at UAB. [unreadable] [unreadable]..
  17. A Model System for the Study of Human B-cell Tolerance
    Ignacio Sanz; Fiscal Year: 2007
    ..Furthermore, we believe that our results will improve our ability to treat patients with SLE and similar diseases. [unreadable] [unreadable]..
  18. UAB Autoimmunity Center for Excellence
    CHARLES ELSON; Fiscal Year: 2007
    ..abstract_text> ..
  19. Identifying Gene Interactions in SLE by Mixed Chimeras
    Eric Sobel; Fiscal Year: 2006
    ..unreadable] Successful completion of these experiments would identify a novel method of systematically identifying epistatic interactions in an important murine model of SLE. [unreadable] [unreadable]..
  20. Identification of Biomarkers in Sjogren's Syndrome
    IGNACIO E SANZ; Fiscal Year: 2010
    ....
  21. FUNCTIONAL LOCI MODIFYING SLE RENAL DISEASE
    Eric Sobel; Fiscal Year: 2003
    ..abstract_text> ..
  22. Molecular identification of a sialyl 9-O-acetyl transferase
    Shiv Pillai; Fiscal Year: 2008
    ..The gene that codes for an enzyme that controls the strength of the immune response will be studied. This gene may be an important target for the treatment of lupus and other related diseases. [unreadable] [unreadable] [unreadable]..
  23. Isoforms of Human Terminal Transferase and Lymphopoiesis
    John Kearney; Fiscal Year: 2007
    ..abstract_text> ..
  24. alpha4beta1 Intergrin Signaling In Immunity And Arthritis
    GREGG JOSHUA SILVERMAN; Fiscal Year: 2010
    ..Collectively, this work will provide insight into the role of the ct4-paxillin interaction in inflammation and immunity, and whether this interaction is a potential bona fide therapeutic target for arthritis. ..
  25. Effect of BAFF on threshold of B cell tolerance
    David Nemazee; Fiscal Year: 2010
    ..The long-term goal of these studies is to understand how BAFF promotes Sjogren's Syndrome and to determine the basic parameters regulating immune tolerance. ..
  26. Early Regulation of Immunity in the Respiratory Tract
    Nicole Baumgarth; Fiscal Year: 2007
    ..This information could help the development of novel interventions that utilize early respiratory tract defenses for immune protection. [unreadable] [unreadable]..
  27. B LYMPHOCYTE INDUCED MATURATION PROTEIN
    Kathryn Calame; Fiscal Year: 2007
    ..We will purify Blimp-1-containing repression complexes and identify the components of the complexes. ..
  28. B LYMPHOCYTE TOLERANCE IN HEALTH AND AUTOIMMUNITY
    David Nemazee; Fiscal Year: 2009
    ....
  29. Lineage decision in blood stem and progenitor cells
    Koichi Akashi; Fiscal Year: 2007
    ..Thus, we hope these studies will help understand mechanistic effects of these transcription factors on lineage decision in normal and malignant hematopoietic development. ..
  30. The role of PKK in NFkappa B activation
    Shiv Pillai; Fiscal Year: 2007
    ..PKK represents a novel enzyme that may be critical in pathways that are important in cancer, inflammation, cell survival, and differentiation. ..
  31. MECHANISMS OF AUTOREACTIVITY IN SLE
    Robert Eisenberg; Fiscal Year: 2009
    ..Such insights should be readily translatable to human autoimmune diseases. ..
  32. RHEUMATIC DISEASES CORE CENTER
    Gregg Silverman; Fiscal Year: 2006
    ..An Administrative Core (PI-G.J. Silverman, Center Director) will provide overall direction and supervision to all Center programs through an Executive Committee, which will be assisted by an Outside Advisory Committee. ..
  33. Arthritis Research Conference 2007
    Gregg Silverman; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  34. Tolerance in polyclonal and oligoclonal immune systems
    Roberta Pelanda; Fiscal Year: 2007
    ..abstract_text> ..
  35. Role of Galectin-4 in Colitis
    Atsushi Mizoguchi; Fiscal Year: 2008
    ..These studies will not only enhance understanding of the pathogenic mechanisms of IBD but also provide important information to develop new therapeutic approaches for human IBD. ..
  36. Primary Immune Deficiency Consortium Conference
    Charlotte Cunningham Rundles; Fiscal Year: 2008
    ..Principle topics will focus on: Diagnosis of Immunodeficiency; Genetics, Immune Reconstruction, and the Use of Standard and Novel Therapies. ..
  37. Pseudomonas in Cystic Fibrosis-Regulation of Mucoidy
    Vojo Deretic; Fiscal Year: 2006
    ..These studies are expected to improve our understanding of respiratory pathogenesis in CF, and lead to new treatments of presently incurable lung infections associated with this disease...
  38. FLUORESCENCE ACTIVATED CELL SORTER
    Tony Marion; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  39. BLyS, APRIL and antibody production in HIV infection
    Andrea Cerutti; Fiscal Year: 2004
    ..Aim 1. To analyze the mechanisms by which HIV up-regulates BLyS and APRIL in APCs. Aim 2. To analyze the role of BLyS and APRIL in the modulation of HIV-induced antibody production. ..
  40. IGM POLYMERIZATION AND J CHAIN EXPRESSION
    RONALD CORLEY; Fiscal Year: 2004
    ..Together, the results of these experiments will provide novel insights into the role of IgM in natural immunity and in disease, and will also shed new light on the pathogenic effects of monomeric IgM. ..
  41. CD8 LYMPHOCYTE RESPONSES IN SIV PATHOGENESIS
    JOERN SCHMITZ; Fiscal Year: 2004
    ..Determine the contribution of CD8+ lymphocytes to the loss of CD4+ Tcells following infection by SIVmac or the rapidly CD4+T cell-depleting virus SHIV-KB9. ..
  42. ROLE OF CD30: CD153-PATHOGENESIS OF RHEUMATOID ARTHRITIS
    Andrea Cerutti; Fiscal Year: 2003
    ..In addition to elucidating the pathogenesis of RA, the experiments outlined in this application should allow to devise new strategies aimed at reducing the production of pathogenic antibodies, including rheumatoid factors. ..
  43. MODULATION OF CLASS II ANTIGEN PROCESSING BY HLA DO
    LISA DENZIN; Fiscal Year: 2003
    ..The proposed work should answer important questions about the role of DO the class II processing pathway and has relevance in such areas as tumor surveillance and autoimmunity. ..
  44. FLOW CYTOMETER
    Tony Marion; Fiscal Year: 2003
    ..abstract_text> ..
  45. T LINEAGE COMMITMENT AND DEVELOPMENT
    Kenneth Dorshkind; Fiscal Year: 2002
    ..Taken together, these studies will establish lineage relationships during early T cell development and hematopoiesis and further characterize the thymic microenvironment. ..
  46. MEMBRANE IMMUNOGLOBULIN ASSEMBLY AND FUNCTION
    Shiv Pillai; Fiscal Year: 2002
    ..Since the majority of human lymphomas develop form activated B-cells, these signaling mechanisms are likely to be of direct relevance for a significant proportion of human cancers. ..
  47. REGULATION AND FUNCTION OF AP1 IN MATURE B CELLS
    THOMAS CHILES; Fiscal Year: 2001
    ....
  48. CELLULAR AND MOLECULAR EVENTS IN B LYMPHOCYTE ACTIVATION
    RONALD CORLEY; Fiscal Year: 2001
    ..These experiments may also provide novel insights into the molecular basis for immunodeficiencies, and provide the tools necessary to study the intracellular transport of viruses and viral particles, and other infectious agents. ..
  49. Studies on human peripheral B lymphocytes
    Shiv Pillai; Fiscal Year: 2005
    ....
  50. Alcoholism: Modulation & Function of Lymphocyte Subsets
    Robert Cook; Fiscal Year: 2005
    ....
  51. H2-O Mediated Antigen Focusing Modulates B Cell Immunity
    LISA DENZIN; Fiscal Year: 2009
    ..The proposed studies will elucidate the role of H2-O in the class II antigen-processing pathway in vivo, during immune responses. These studies are relevant for tumor immunity, autoimmunity and vaccine development. ..
  52. Regulation of E2A in Normal and Aged B Lymphopoiesis
    Richard Riley; Fiscal Year: 2008
    ..More broadly, these studies will further our understanding of the immune defects which accompany old age and their cellular and molecular mechanisms. ..
  53. Role and Regulation of BLIMP-1 in Myeloid Cells
    Kathryn Calame; Fiscal Year: 2006
    ..Finally, the signals and mechanisms responsible for regulation of Blimp-1 expression in myeloid cells will be studied. ..
  54. TRANSCRIPTION OF IMMUNOGLOBULIN HEAVY CHAIN GENES
    Kathryn Calame; Fiscal Year: 2001
    ....
  55. MICROBES, DENDRITIC CELL SUBSETS AND T-CELL IMMUNITY
    Bali Pulendran; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  56. Assessment of BAFF as a mucosal HIV DNA vaccine adjuvant
    David Nemazee; Fiscal Year: 2005
    ....
  57. ANTHRAX TOXIN, DENDRITIC CELLS AND ADAPTIVE IMMUNITY
    Bali Pulendran; Fiscal Year: 2006
    ....
  58. Cell Death and Antibody-Mediated Protection from Autoimmunity
    GREGG JOSHUA SILVERMAN; Fiscal Year: 2010
    ....
  59. 2002 Summer School in Primary Immunodeficiency Disorders
    Charlotte Cunningham Rundles; Fiscal Year: 2002
    ..Fellows participating in the course will be reimbursed for their travel expenses. No registration fee will be charged for the fellows participating in the program. ..
  60. MECHANISMS OF IL-2 IMMUNE ENHANCEMENT IN HUMANS
    Charlotte Cunningham Rundles; Fiscal Year: 2001
    ..Thus, this application will focus on the cellular and molecular mechanisms by which IL-2 reconstitutes T cell immunity in this model system. ..
  61. Primary Immunne Deficiency Consortium Conference
    Charlotte Cunningham Rundles; Fiscal Year: 2005
    ..Principle topics will focus on: Antibody Deficiency; Combined Immune Defects; Neutrophil Disorders; Laboratory Evaluation of Primary Immunodeficiency; Immune Reconstiution, and the Use of Standard and Novel Therapies. ..
  62. ROLE FOR THE ECTOENZYME CD38 IN IMMUNE RESPONSES
    Frances Lund; Fiscal Year: 2003
    ..These experiments will provide a framework for understanding the elusive role of ecto-enzymes such as CD38 in the generation and maintenance of protective immunity. ..
  63. DIFFERENTIATIVE PROGRAMS OF LYMPHOID PROGENITOR CELLS
    TUCKER LEBIEN; Fiscal Year: 2004
    ..The collective results from these studies will enhance our understanding of the normal developmental program of human B lymphocytes and perturbations in the program that can give rise to leukemia and immunodeficiency. ..
  64. Natural IgM antilymphocyte autoantibodies inhibit HIV-1
    PETER LOBO; Fiscal Year: 2003
    ..A successful outcome with the proposed studies could better our understanding on pathogenesis of H1V-1 infection and may provide strategies to prolong the asymptomatic state after HIV-1 infection. ..
  65. Transcription Regulation by B-Cell Receptor Signaling
    Wasif Khan; Fiscal Year: 2004
    ..Identification of these important missing links may reveal new immunotherapeutic targets for intervention in B-cell deficiency diseases such as XLA. ..
  66. Periodontal Assessment in RA Study (PARAS)
    Clifton Bingham; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  67. Stage-specific Signaling in Peripheral B Cell Selection
    Wasif N Khan; Fiscal Year: 2010
    ..This new knowledge can lead to the development of novel therapeutics for the treatment of B cell-mediated autoimmune diseases and immunodeficiencies and B cell lymphomas. ..
  68. NAD and CD38: modulators of inflammation and immunity
    Frances E Lund; Fiscal Year: 2010
    ..Thus, it is one of NIAID's highest priorities (NOT-AI-05-013) that we develop more effective influenza vaccines that are protective against a wide array of different viral serotypes. ..
  69. Mechanisms regulating immunoglobulin gene transcription
    Barbara Nikolajczyk; Fiscal Year: 2007
    ..In addition understanding the rules for tissue-specific gene expression will allow exquisitely regulated delivery of treatments for a variety of single tissue syndromes from cancer to diabetes. ..
  70. T-Cell Dependent Immune Responses and Ethanol
    Robert Cook; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  71. Immunopathology Training Grant
    Kenneth Dorshkind; Fiscal Year: 2007
    ..This research is conducted in the Department of Pathology and Laboratory Medicine. ..