b lymphocyte subsets

Summary

Summary: A classification of B-lymphocytes based on structurally or functionally different populations of cells.

Top Publications

  1. ncbi Chronic intestinal inflammatory condition generates IL-10-producing regulatory B cell subset characterized by CD1d upregulation
    Atsushi Mizoguchi
    Immunopathology Unit, Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA
    Immunity 16:219-30. 2002
  2. ncbi Maintenance of serological memory by polyclonal activation of human memory B cells
    Nadia L Bernasconi
    Institute for Research in Biomedicine, Via Vela 6, CH 6500 Bellinzona, Switzerland
    Science 298:2199-202. 2002
  3. ncbi Disturbed peripheral B lymphocyte homeostasis in systemic lupus erythematosus
    M Odendahl
    Deutsches Rheuma ForschungsZentrum Berlin, Charite University Hospital, Berlin, Germany
    J Immunol 165:5970-9. 2000
  4. pmc Phenotypic and functional heterogeneity of human memory B cells
    Inaki Sanz
    Division of Allergy, Immunology and Rheumatology, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Semin Immunol 20:67-82. 2008
  5. ncbi A case for regulatory B cells
    Atsushi Mizoguchi
    Immunopathology Unit, Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Immunol 176:705-10. 2006
  6. ncbi B-1 cells: the lineage question revisited
    L A Herzenberg
    Department of Genetics, Stanford University School of Medicine, CA 94305, USA
    Immunol Rev 175:9-22. 2000
  7. ncbi Marginal-zone B cells
    Flavius Martin
    Department of Microbiology, University of Alabama at Birmingham, 35294 3300, USA
    Nat Rev Immunol 2:323-35. 2002
  8. ncbi Positive selection of natural autoreactive B cells
    K Hayakawa
    Institute for Cancer Research, Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111, USA
    Science 285:113-6. 1999
  9. pmc Discriminating gene expression profiles of memory B cell subpopulations
    Gotz R A Ehrhardt
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Exp Med 205:1807-17. 2008
  10. ncbi IL-10 regulation of lupus in the NZM2410 murine model
    Kim R M Blenman
    Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL 32601 0275, USA
    Lab Invest 86:1136-48. 2006

Detail Information

Publications221 found, 100 shown here

  1. ncbi Chronic intestinal inflammatory condition generates IL-10-producing regulatory B cell subset characterized by CD1d upregulation
    Atsushi Mizoguchi
    Immunopathology Unit, Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA
    Immunity 16:219-30. 2002
    ..This study indicates that B cells, by producing cytokines such as IL-10, can act as regulatory cells in immunologically mediated inflammatory reactions...
  2. ncbi Maintenance of serological memory by polyclonal activation of human memory B cells
    Nadia L Bernasconi
    Institute for Research in Biomedicine, Via Vela 6, CH 6500 Bellinzona, Switzerland
    Science 298:2199-202. 2002
    ..Although antigen boosting leads to a transient increase in specific antibody levels, ongoing polyclonal activation of memory B cells offers a means to maintain serological memory for a human lifetime...
  3. ncbi Disturbed peripheral B lymphocyte homeostasis in systemic lupus erythematosus
    M Odendahl
    Deutsches Rheuma ForschungsZentrum Berlin, Charite University Hospital, Berlin, Germany
    J Immunol 165:5970-9. 2000
    ..These results indicate that there are profound abnormalities in the various B cell compartments in SLE that respond differently to immunosuppressive therapy...
  4. pmc Phenotypic and functional heterogeneity of human memory B cells
    Inaki Sanz
    Division of Allergy, Immunology and Rheumatology, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Semin Immunol 20:67-82. 2008
    ....
  5. ncbi A case for regulatory B cells
    Atsushi Mizoguchi
    Immunopathology Unit, Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Immunol 176:705-10. 2006
    ..In this review, we make a case for the existence of regulatory B cells and discuss the possible developmental pathways and functional mechanisms of these B cells...
  6. ncbi B-1 cells: the lineage question revisited
    L A Herzenberg
    Department of Genetics, Stanford University School of Medicine, CA 94305, USA
    Immunol Rev 175:9-22. 2000
    ....
  7. ncbi Marginal-zone B cells
    Flavius Martin
    Department of Microbiology, University of Alabama at Birmingham, 35294 3300, USA
    Nat Rev Immunol 2:323-35. 2002
    ..Now that the initial 'infatuation' is over, it is time to reconsider these data and generate some conclusions that can be incorporated into a working model of the B-cell system...
  8. ncbi Positive selection of natural autoreactive B cells
    K Hayakawa
    Institute for Cancer Research, Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111, USA
    Science 285:113-6. 1999
    ..Thus, B cells can be subject to positive selection, generated, and maintained on the basis of their autoreactivity...
  9. pmc Discriminating gene expression profiles of memory B cell subpopulations
    Gotz R A Ehrhardt
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Exp Med 205:1807-17. 2008
    ....
  10. ncbi IL-10 regulation of lupus in the NZM2410 murine model
    Kim R M Blenman
    Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL 32601 0275, USA
    Lab Invest 86:1136-48. 2006
    ..These results also reinforce the notion that IL-10 exerts multiple functions and commend caution in equating high levels of IL-10 and increased pathogenesis in systemic autoimmunity...
  11. pmc Toll-like receptor expression and responsiveness of distinct murine splenic and mucosal B-cell subsets
    Murali Gururajan
    Vaccine Research Center, Emory University, Atlanta, Georgia, United States of America
    PLoS ONE 2:e863. 2007
    ..Furthermore, the expression and functional relevance of TLRs on distinct subsets of B cells, which are known to play differential roles in humoral responses is not known...
  12. pmc Somatic diversification in the absence of antigen-driven responses is the hallmark of the IgM+ IgD+ CD27+ B cell repertoire in infants
    Sandra Weller
    Institut National de la Santé et de la Recherche Médicale U783, Développement du Système Immunitaire, Universite Paris Descartes, Faculte de Medecine, Site Necker Enfants Malades, Paris 75015, France
    J Exp Med 205:1331-42. 2008
    ..These data provide evidence for the developmental diversification of IgM(+)IgD(+)CD27(+) B cells, at least in very young children, outside of T cell-dependent and -independent immune responses...
  13. pmc A distinct Toll-like receptor repertoire in human tonsillar B cells, directly activated by PamCSK, R-837 and CpG-2006 stimulation
    Anne Mansson
    Laboratory of Clinical and Experimental Allergy Research, Department of Otorhinolaryngology, Malmo University Hospital, Lund University, Sweden
    Immunology 118:539-48. 2006
    ..Furthermore, the distinct expression of TLRs allows B cells to respond directly to the cognate PAMPs. This further emphasizes the role of TLRs in directly activating adaptive immune cells...
  14. ncbi The 'short' history of regulatory B cells
    Claudia Mauri
    Department of Medicine, University College London, 46 Cleveland Street, London W1T 4JF, UK
    Trends Immunol 29:34-40. 2008
    ..The identification of their existence is of great relevance to the understanding of autoimmune diseases and to the development of new therapeutic strategies...
  15. pmc TLR-mediated stimulation of APC: Distinct cytokine responses of B cells and dendritic cells
    Tom A Barr
    Institute of Immunology and Infection Research, School of Biological Science, University of Edinburgh, Edinburgh, UK
    Eur J Immunol 37:3040-53. 2007
    ..QRT-PCR array data indicate that this may be due to differential expression of TLR signalling molecules, effectors and adaptors. Our data highlight the potentially unique nature of immune modulation when B cells act as APC...
  16. ncbi Impairment of T-cell-dependent B-cell responses and B-1 cell development in CD19-deficient mice
    R C Rickert
    Institute for Genetics, University of Cologne, Germany
    Nature 376:352-5. 1995
    ..2)...
  17. ncbi An essential role for BAFF in the normal development of B cells through a BCMA-independent pathway
    B Schiemann
    Biogen, 14 Cambridge Center, Cambridge, MA 02142, USA
    Science 293:2111-4. 2001
    ..In contrast, mice lacking BCMA had normal-appearing B lymphocyte compartments. BAFF therefore plays a crucial role in B cell development and can function through receptors other than BCMA...
  18. ncbi B cells activated by lipopolysaccharide, but not by anti-Ig and anti-CD40 antibody, induce anergy in CD8+ T cells: role of TGF-beta 1
    Vrajesh V Parekh
    National Center for Cell Science, Pune, Maharashtra, India School of Biotechnology, Devi Ahilya Vishwavidyalaya, Indore, Madhya Pradesh, India
    J Immunol 170:5897-911. 2003
    ..Therefore, this study, for the first time, provides a novel mechanism of B cell surface TGF-beta1-mediated hyporesponsiveness leading to anergy of CD8(+) T cells...
  19. ncbi Development of B cells producing natural autoantibodies to thymocytes and senescent erythrocytes
    Richard R Hardy
    Division of Basic Sciences, Fox Chase Cancer Center, 333 Cottman Ave, Philadelphia, PA 19111, USA
    Springer Semin Immunopathol 26:363-75. 2005
    ....
  20. ncbi Latent membrane protein 2A, a viral B cell receptor homologue, induces CD5+ B-1 cell development
    Akiko Ikeda
    Department of Microbiology Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    J Immunol 172:5329-37. 2004
    ..Furthermore, these studies offer insight into EBV latency and pathogenesis in the human host...
  21. pmc Homeostatic control of B lymphocyte subsets
    Jenni E Crowley
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 284 John Morgan Building 36th and Hamilton Walk, Philadelphia, PA, 19104 6082, USA
    Immunol Res 42:75-83. 2008
    ..A refined understanding of these relationships should yield insight into the selection and maintenance of B cell subsets, as well as an appreciation of how homeostatic mechanisms may contribute to immunosenescence...
  22. ncbi CD38 low IgG-secreting cells are precursors of various CD38 high-expressing plasma cell populations
    Sergio Arce
    Deutsches Rheuma ForschungsZentrum Berlin, Schumannstrasse 20 21, D 10117 Berlin, Germany
    J Leukoc Biol 75:1022-8. 2004
    ..These data are compatible with a multistep model for plasma cell differentiation and imply that a common CD38 low IgG-secreting precursor gives rise to a diverse plasma cell compartment...
  23. ncbi Association of B-1 B cells with follicular dendritic cells in spleen
    Lijun Wen
    Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    J Immunol 174:6918-26. 2005
    ..These results indicate that B-1 B cells are the first B cells to express fully mature levels of CXCR5, thereby promoting the development of FDC...
  24. ncbi Ig gene rearrangement steps are initiated in early human precursor B cell subsets and correlate with specific transcription factor expression
    Menno C van Zelm
    Department of Immunology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
    J Immunol 175:5912-22. 2005
    ....
  25. doi Identification and characterization of a human CD5+ pre-naive B cell population
    Jisoo Lee
    Department of Internal Medicine, Ewha Womans University School of Medicine, Seoul, Korea
    J Immunol 182:4116-26. 2009
    ..These results have identified a unique intermediate in human naive B cell development within the peripheral blood and derangements of its homeostasis in patients with systemic lupus erythematosus...
  26. ncbi Regulatory mechanisms that determine the development and function of plasma cells
    Kathryn L Calame
    Department of Microbiology and Biochemistry, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Annu Rev Immunol 21:205-30. 2003
    ..Thus, commitment to plasmacytic differentiation involves inhibition of activities associated with earlier B cell developmental stages as well as expression of the plasma cell phenotype...
  27. ncbi B lymphocyte depletion by CD20 monoclonal antibody prevents diabetes in nonobese diabetic mice despite isotype-specific differences in Fc gamma R effector functions
    Yan Xiu
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 180:2863-75. 2008
    ..Moreover, this study defines a new, clinically relevant approach whereby B cell depletion early in the course of disease development may prevent diabetes or delay progression of disease...
  28. ncbi B-cell commitment, development and selection
    R R Hardy
    Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Immunol Rev 175:23-32. 2000
    ..Finally, we describe a new VH3609 antithymocyte Ig transgenic mouse model system that has provided the first definitive evidence for the role of self-antigen in development and maintenance of natural autoreactive B cells...
  29. ncbi Correlation between circulating CD27high plasma cells and disease activity in patients with systemic lupus erythematosus
    Annett M Jacobi
    University Hospital Charite, Berlin, Germany
    Arthritis Rheum 48:1332-42. 2003
    ..In order to determine whether SLE disease activity correlates with abnormal B lymphocyte activity, B cell subsets were analyzed, and their relationship to clinical and humoral measures of disease activity was assessed...
  30. ncbi Helicobacter pylori vacuolating cytotoxin inhibits activation-induced proliferation of human T and B lymphocyte subsets
    Victor J Torres
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232 2605, USA
    J Immunol 179:5433-40. 2007
    ..We propose that the immunomodulatory actions of VacA on T and B lymphocytes, the major effectors of the adaptive immune response, may contribute to the ability of H. pylori to establish a persistent infection in the human gastric mucosa...
  31. pmc Follicular lymphoma-like B cells in healthy individuals: a novel intermediate step in early lymphomagenesis
    Sandrine Roulland
    Centre d immunologie de Marseille Luminy, Universite de la Mediterranee, 13288 Marseille, France
    J Exp Med 203:2425-31. 2006
    ..These findings strongly impact both on the current understanding of disease progression and on the proper handling of t(14;18) frequency in blood as a potential early biomarker for lymphoma...
  32. ncbi The human immunomodulatory CD25+ B cell population belongs to the memory B cell pool
    S Amu
    Department of Rheumatology and Inflammation Research, Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    Scand J Immunol 66:77-86. 2007
    ..In conclusion, CD20(+)25(+) B cells constitute a unique subpopulation preferentially occurring among CD20(+)27(+) memory B cells. We suggest that CD25 can be used as a marker for a memory B cell subset...
  33. ncbi DNA fiber fluorescence in situ hybridization analysis of immunoglobulin class switching in B-cell neoplasia: aberrant CH gene rearrangements in follicle center-cell lymphoma
    J W Vaandrager
    Department of Pathology, Hematology, Cytometry and Cytochemistry, Leiden University Medical Centre, Leiden, The Netherlands
    Blood 92:2871-8. 1998
    ..Fiber FISH analysis also showed several polymorphisms. The most frequent one, present on 38% of all analyzed alleles, consisted of an extra Cgamma gene or pseudogene in the 3' cluster...
  34. ncbi Chemotaxis of human tonsil B lymphocytes to CC chemokine receptor (CCR) 1, CCR2 and CCR4 ligands is restricted to non-germinal center cells
    Anna Corcione
    Laboratory of Oncology, G Gaslini Institute, Largo G Gaslini 5, 16148 Genova, Italy
    Int Immunol 14:883-92. 2002
    ..CCR1, CCR2 and CCR4 were detected by flow cytometry on non-GC (i.e. naive and memory) B cells, whereas they were absent (CCR1 and CCR2) or poorly expressed (CCR4) on GC B cells...
  35. ncbi B-1a and B-1b cells exhibit distinct developmental requirements and have unique functional roles in innate and adaptive immunity to S. pneumoniae
    Karen M Haas
    Department of Immunology, Box 3010, Duke University Medical Center, Durham, North Carolina 27710, USA
    Immunity 23:7-18. 2005
    ..This reciprocal contribution of B-1a and B-1b subsets to innate and acquired immunity reveals an unexpected division of labor within the B-1 compartment that is normally balanced by their coordinated development...
  36. ncbi Autoreactivity by design: innate B and T lymphocytes
    A Bendelac
    Department of Molecular Biology, Princeton University, New Jersey 08544, USA
    Nat Rev Immunol 1:177-86. 2001
    ..New studies have shed light on the principles and mechanisms that drive their unique development and function, and show their resemblance to another subset of innate lymphocytes, the natural killer cells...
  37. ncbi Generation of migratory antigen-specific plasma blasts and mobilization of resident plasma cells in a secondary immune response
    Marcus Odendahl
    Department of Medicine, Charite, Humbold University, D 10117 Berlin, Germany
    Blood 105:1614-21. 2005
    ....
  38. ncbi Defective development and function of Bcl10-deficient follicular, marginal zone and B1 B cells
    Liquan Xue
    Department of Pathology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Nat Immunol 4:857-65. 2003
    ..Thus, Bcl10 is essential for the development of all mature B cell subsets...
  39. ncbi Germinal centers regulate human Th2 development
    Bengt Johansson-Lindbom
    Department of Immunotechnology, Lund University, Lund, Sweden
    J Immunol 171:1657-66. 2003
    ....
  40. ncbi Regulation and function of cyclin D2 in B lymphocyte subsets
    Thomas C Chiles
    Department of Biology, Boston College, Chestnut Hill, MA 02467, USA
    J Immunol 173:2901-7. 2004
    ..This review focuses on recent progress toward understanding the function of cyclin D2 in cell cycle control, and in the development of murine B lymphocytes...
  41. ncbi Cutting edge commentary: origins of B-1 cells
    H H Wortis
    Department of Pathology, Tufts University School of Medicine and Program in Immunology, Sackler School of Graduate Biomedical Sciences, Boston MA 02111, USA
    J Immunol 166:2163-6. 2001
    ..CD5 expression and possibly localization to the peritoneum appear to provide some protection to autoreactive cells otherwise slated for elimination...
  42. ncbi Distinct signaling mechanisms activate the target of rapamycin in response to different B-cell stimuli
    Amber C Donahue
    Department of Molecular Biology and Biochemistry, and Center for Immunology, University of California Irvine, Irvine, CA 92697 3900, USA
    Eur J Immunol 37:2923-36. 2007
    ..These data define both similarities and differences in PI3K/mTOR signaling mechanisms in MZ and FO cells, and suggest that mTOR signaling can occur in the absence of PI3K activation to promote B cell responses to LPS...
  43. ncbi Activated memory B cell subsets correlate with disease activity in systemic lupus erythematosus: delineation by expression of CD27, IgD, and CD95
    Annett M Jacobi
    Charite Universitatsmedizin Berlin, Berlin, Germany
    Arthritis Rheum 58:1762-73. 2008
    ..Focusing on CD27- B cells, this study aimed to identify abnormalities in peripheral B cell subsets in patients with SLE...
  44. pmc Expression of the immunoregulatory molecule FcRH4 defines a distinctive tissue-based population of memory B cells
    Gotz R A Ehrhardt
    Division of Clinical and Developmental Immunology, University of Alabama at Birmingham, Birmingham, Birmingham, AL 35294, USA
    J Exp Med 202:783-91. 2005
    ..Cell surface FcRH4 expression thus marks a unique population of memory B cells with distinctive morphology, functional capabilities, and tissue localization...
  45. pmc HIV-1 induces phenotypic and functional perturbations of B cells in chronically infected individuals
    S Moir
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, and Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 98:10362-7. 2001
    ..These results indicate that HIV viremia induces the appearance of a subset of B cells whose function is impaired and which may be responsible for the hypergammaglobulinemia associated with HIV disease...
  46. ncbi B cell-specific deletion of protein-tyrosine phosphatase Shp1 promotes B-1a cell development and causes systemic autoimmunity
    Lily I Pao
    Cancer Biology Program, Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
    Immunity 27:35-48. 2007
    ..Thus, Shp1 deficiency in B cells alone perturbs B cell development and causes autoimmune disease...
  47. ncbi B1 cells: similarities and differences with other B cell subsets
    F Martin
    Division of Developmental and Clinical Immunology, Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294-3300, USA
    Curr Opin Immunol 13:195-201. 2001
    ..Most advances have been made in describing the physiological activities of B1 cells, including their migration, activation by antigen and role in both autoimmunity and malignancy...
  48. ncbi Signaling via LTbetaR on the lamina propria stromal cells of the gut is required for IgA production
    Hyung Sik Kang
    Department of Pathology and Committee on Immunology, The University of Chicago, 5841 S Maryland, Chicago, IL 60637, USA
    Nat Immunol 3:576-82. 2002
    ....
  49. ncbi IgA and IgM V(H) repertoires in human colon: evidence for clonally expanded B cells that are widely disseminated
    W Holtmeier
    Medizinische Klinik II, Johann Wolfgang Goethe Universitdt, Frankfurt am Main, Germany
    Gastroenterology 119:1253-66. 2000
    ..Because lamina propria B cells should reflect the antigenic experience of the gut, we investigated their immunoglobulin (Ig) repertoire and distribution...
  50. ncbi Impact of the BAFF/BR3 axis on B cell survival, germinal center maintenance and antibody production
    Susan L Kalled
    Biogen Idec, Inc, 12 Cambridge Center, Cambridge, MA 02142, USA
    Semin Immunol 18:290-6. 2006
    ..These include germinal center maintenance, isotype switching, and regulation of specific B cell surface markers. More importantly, a role for BAFF in B cell biology has been validated in vivo in humans...
  51. doi Regulatory role of B-1 B cells in chronic colitis
    Yasuyo Shimomura
    Experimental Pathology, Massachusetts General Hospital, Boston, MA 02114, USA
    Int Immunol 20:729-37. 2008
    ..We conclude that B-1 cells play a regulatory role in T(h)2-mediated colitis under non-hygienic conditions, possibly by generating natural antibodies in response to microbial flora...
  52. ncbi TLR agonists selectively promote terminal plasma cell differentiation of B cell subsets specialized in thymus-independent responses
    Laurent Genestier
    Institut National de la Santé et de la Recherche Médicale Unité 851, IFR128 Biosciences Lyon Gerland, 21 Avenue Tony Garnier, Lyon, France
    J Immunol 178:7779-86. 2007
    ....
  53. ncbi B cells acquire particulate antigen in a macrophage-rich area at the boundary between the follicle and the subcapsular sinus of the lymph node
    Yolanda R Carrasco
    Lymphocyte Interaction Laboratory, Cancer Research United Kingdom London Research Institute, Lincoln s Inn Fields Laboratories, 44 Lincoln s Inn Fields, London WC2A 3PX, United Kingdom
    Immunity 27:160-71. 2007
    ..These observations not only provide evidence of a B cell role as antigen transporters into the follicle, but also highlight the boundary between the follicle and the SCS as a site for initiation of B cell responses...
  54. ncbi CD1 expression defines subsets of follicular and marginal zone B cells in the spleen: beta 2-microglobulin-dependent and independent forms
    M Amano
    Department of Medicine, Stanford University School of Medicine, CA 94305 5111, USA
    J Immunol 161:1710-7. 1998
    ..They further suggest that a beta 2m-independent form of CD1 is expressed on B cells that can stimulate T cells; however, this form is not easily visualized with the anti-CD1 mAb used here...
  55. ncbi Transitional type 1 and 2 B lymphocyte subsets are differentially responsive to antigen receptor signaling
    James B Petro
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0146, USA
    J Biol Chem 277:48009-19. 2002
    ..In turn, these signaling pathways probably govern the development and selection processes that are critical for the formation of the mature B cell compartment...
  56. ncbi B cell development pathways
    R R Hardy
    Institute for Cancer Research, Fox Chase Cancer Center, 7701 Burholme Ave, Philadelphia, Pennsylvania 19111, USA
    Annu Rev Immunol 19:595-621. 2001
    ....
  57. ncbi deltaBAFF, a splice isoform of BAFF, opposes full-length BAFF activity in vivo in transgenic mouse models
    Amanda L Gavin
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunol 175:319-28. 2005
    ..In contrast, BAFF transgenic mice had extraordinarily elevated Ig levels and increases in subsets of B cells. Unexpectedly, both BAFF and DeltaBAFF appeared to modulate the numbers of B-1 phenotype B cells...
  58. doi HLA-DRhigh/CD27high plasmablasts indicate active disease in patients with systemic lupus erythematosus
    A M Jacobi
    Charite Universitatsmedizin Berlin, Chariteplatz 1, 10098 Berlin, Germany
    Ann Rheum Dis 69:305-8. 2010
    ..A similar subset has also been identified 6-8 days after tetanus/diphtheria vaccination in normal individuals and in patients with infectious disease...
  59. ncbi Identification of transitional type II B cells in the salivary glands of patients with Sjögren's syndrome
    Capucine Daridon
    Laboratory of Immunology, Brest University Medical School Hospital, BP824, F 29609 Brest, France
    Arthritis Rheum 54:2280-8. 2006
    ..A special emphasis was placed on those B lymphocytes included in the ectopic germinal centers (GCs)...
  60. pmc Perturbations of peripheral B lymphocyte homoeostasis in children with systemic lupus erythematosus
    M Odendahl
    Deutsches Rheuma ForschungsZentrum Berlin, Germany
    Ann Rheum Dis 62:851-8. 2003
    ..To investigate the distribution of peripheral B cell subpopulations of children with active and inactive systemic lupus erythematosus (SLE) compared with healthy controls...
  61. ncbi TNF deficiency fails to protect BAFF transgenic mice against autoimmunity and reveals a predisposition to B cell lymphoma
    Marcel Batten
    Department of Arthritis and Inflammation, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, New South Wales 2010, Australia
    J Immunol 172:812-22. 2004
    ....
  62. pmc Is the blood B-cell subset profile diagnostic for Sjogren syndrome?
    A Binard
    EA Immunologie et Pathologie, Universite Europeenne de Bretagne, et Université de Bretagne Occidentale, Brest, et Centre Hospitalier Universitaire de Brest, Brest F29609, France
    Ann Rheum Dis 68:1447-52. 2009
    ..To evaluate the relevance of the blood B-cell subset profile for the diagnosis of Sjögren syndrome...
  63. ncbi Immunological defects in mice with a targeted disruption in Bcl-3
    E M Schwarz
    Laboratory of Genetics, The Salk Institute, San Diego, California 92186 5800, USA
    Genes Dev 11:187-97. 1997
    ..Additionally, spleens from Bcl-3(-/-) mice are abnormal and void of germinal centers. In contrast, the p50(-/-) mice have normal germinal centers. We propose that in in vivo, Bcl-3 can function independently of p50...
  64. ncbi Disruption of the Cr2 locus results in a reduction in B-1a cells and in an impaired B cell response to T-dependent antigen
    J M Ahearn
    Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Immunity 4:251-62. 1996
    ..These results indicate an obligatory role of B cell complement receptors in responses of the B cells to protein antigens...
  65. ncbi Uncoupling of anergy from developmental arrest in anti-insulin B cells supports the development of autoimmune diabetes
    Carlos A Acevedo-Suárez
    Department of Medicine, Vanderbilt University, Nashville, TN 37232, USA
    J Immunol 174:827-33. 2005
    ..These findings suggest that the degree of functional impairment, rather than an overt breach of tolerance, is a critical feature that governs B cell contribution to T cell-mediated autoimmune disease...
  66. pmc B cells in autoimmunity
    Thomas Dorner
    Charite Center 12 and 14, Charite University Hospital and DRFZ Berlin, Chariteplatz 01, 10098 Berlin, Germany
    Arthritis Res Ther 11:247. 2009
    ..Based on preclinical and clinical data, B cells have emerged increasingly as both effector cells as well as cells with immunoregulatory potential...
  67. ncbi Regulation of BCR signal transduction in B-1 cells requires the expression of the Src family kinase Lck
    Joseph M Dal Porto
    Integrated Department of Immunology, National Jewish Medical and Research Center, University of Colorado School of Medicine, Denver 80206, USA
    Immunity 21:443-53. 2004
    ..Interestingly, lck-null mice exhibited increased natural antibody levels characteristic of B-1 cells. Taken together, these results demonstrate a key role for Lck in modulating the signaling and cellular fate of B-1 B cells...
  68. pmc Recapitulation of B cell differentiation in the central nervous system of patients with multiple sclerosis
    Anna Corcione
    Laboratory of Oncology, Scientific Direction, G Gaslini Institute, 16148 Genoa, Italy
    Proc Natl Acad Sci U S A 101:11064-9. 2004
    ..The presence of lymphotoxin-alpha, CXCL12, and CXCL13 in the CNS may provide favorable microenvironmental conditions for these events...
  69. ncbi Innate-like B cells
    John F Kearney
    Division of Developmental and Clinical Immunology, Department of Microbiology, University of Alabama at Birmingham, WTI 378, 1824 6th Avenue South, Birmingham, AL 35294 3300, USA
    Springer Semin Immunopathol 26:377-83. 2005
    ..These innate-like B cell subsets form a bridge between the rapidly occurring innate immune responses, and the slower acting primary, T cell-dependent, adaptive antibody response by providing a rapid T cell-independent antibody response...
  70. ncbi CD27 expression by a distinct subpopulation of human B lymphocytes
    D Maurer
    Institute of Immunology, Vienna International Research Cooperation Center, Austria
    Eur J Immunol 20:2679-84. 1990
    ..These latter findings suggest that CD27+ B cells are predispose to form cell-cell interactions. Accordingly, within 3 h of cell culture CD27+, but not CD27-, B lymphocytes were found to form LFA-1-mediated homotypic B cell clusters...
  71. ncbi Activation of marginal zone B cells from lupus mice with type A(D) CpG-oligodeoxynucleotides
    Rachel Brummel
    Division of Rheumatology, Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    J Immunol 174:2429-34. 2005
    ..Through increased IL-10 secretion, MZ-B cells may also modify the activity of other cell types, particularly dendritic cells and macrophages...
  72. ncbi Depletion of B cells by a humanized anti-CD20 antibody PRO70769 in Macaca fascicularis
    Yulia Vugmeyster
    Genentech, Inc, South San Francisco, California 94080, USA
    J Immunother 28:212-9. 2005
    ..After recovery, B-cell subsets were reconstituted to normal levels. Depletion of CD20-expressing cells and lymphoid follicular atrophy were the only treatment-related effects...
  73. ncbi Short-lived plasmablasts dominate the early spontaneous rheumatoid factor response: differentiation pathways, hypermutating cell types, and affinity maturation outside the germinal center
    Jacqueline William
    Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    J Immunol 174:6879-87. 2005
    ..These studies provide insights into the unique nature of an ongoing autoimmune response and may be a model for understanding the response to therapies such as B cell depletion...
  74. doi From the fetal liver to spleen and gut: the highway to natural antibody
    M M Rosado
    Research Center, Ospedale Pediatrico Bambino Gesu, IRCCS, Roma, Italy
    Mucosal Immunol 2:351-61. 2009
    ..The natural antibodies in the serum and on the intestinal epithelium may be an evolutionary ancient tool for the immediate protection against commensal and pathogenic bacteria...
  75. ncbi B cell life span: a review
    D A Fulcher
    Centenary Institute of Cancer Medicine and Cell Biology, Sydney, New South Wales, Australia
    Immunol Cell Biol 75:446-55. 1997
    ..This review examines both traditional and recent methods and discusses the influence of age, self-tolerance and randomness in the overall shaping of a kinetically stable mature B cell population...
  76. ncbi A division-linked mechanism for the rapid generation of Ig-secreting cells from human memory B cells
    Stuart G Tangye
    Immune Regulation Group, Centenary Institute of Cancer Medicine and Cell Biology, Sydney, New South Wales, Australia
    J Immunol 170:261-9. 2003
    ....
  77. pmc B cell development in the spleen takes place in discrete steps and is determined by the quality of B cell receptor-derived signals
    F Loder
    Department of Molecular Immunology, University of Freiburg, Germany
    J Exp Med 190:75-89. 1999
    ....
  78. ncbi BLyS: member of the tumor necrosis factor family and B lymphocyte stimulator
    P A Moore
    Human Genome Sciences, 9410 Key West Avenue, Rockville, MD 20850, USA
    Science 285:260-3. 1999
    ..The B cell tropism of BLyS is consistent with its receptor expression on B-lineage cells. The biological profile of BLyS suggests it is involved in monocyte-driven B cell activation...
  79. ncbi Blood dendritic cells interact with splenic marginal zone B cells to initiate T-independent immune responses
    Mercedesz Balazs
    Division of Developmental and Clinical Immunology, Department of Microbiology, University of Alabama, Birmingham, AL 35294, USA
    Immunity 17:341-52. 2002
    ..In the absence of soluble TACI ligands, Ag-activated MZ- and B1-derived blasts lack survival signals and undergo apoptosis, resulting in severely impaired antibody responses...
  80. ncbi Siglec-G is a B1 cell-inhibitory receptor that controls expansion and calcium signaling of the B1 cell population
    Anja Hoffmann
    Department of Genetics, University of Erlangen, 91058 Erlangen, Germany
    Nat Immunol 8:695-704. 2007
    ..Siglec-G-deficient B1 cells showed a strongly enhanced calcium signaling. Our results demonstrate that Siglec-G-dependent negative regulation exists in B1 cells, which may explain the naturally muted signaling response of B1 cells...
  81. ncbi Naive B lymphocytes undergo homeostatic proliferation in response to B cell deficit
    Mark S Cabatingan
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Immunol 169:6795-805. 2002
    ..Homeostatic B cell proliferation provides an Ag-independent mechanism for the maintenance and expansion of naive B cells selected into the mature B cell pool...
  82. ncbi The Rac2 guanosine triphosphatase regulates B lymphocyte antigen receptor responses and chemotaxis and is required for establishment of B-1a and marginal zone B lymphocytes
    Ben A Croker
    Division of Cancer and Hematology and Immunology, Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Parkville, Victoria, Australia
    J Immunol 168:3376-86. 2002
    ..Rac2 is therefore an essential element in regulating B lymphocyte functions and maintaining B lymphocyte populations in vivo...
  83. ncbi B-cell subsets and the mature preimmune repertoire. Marginal zone and B1 B cells as part of a "natural immune memory"
    F Martin
    University of Alabama at Birmingham, 35294 3300, USA
    Immunol Rev 175:70-9. 2000
    ....
  84. ncbi Regulatory B cells as inhibitors of immune responses and inflammation
    Jean David Bouaziz
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    Immunol Rev 224:201-14. 2008
    ..This review focuses on the recent progress in this field and the exciting opportunities for understanding how this unique B-cell subset influences diverse immune functions...
  85. ncbi BAFF-modulated repopulation of B lymphocytes in the blood and salivary glands of rituximab-treated patients with Sjögren's syndrome
    Jacques Olivier Pers
    Brest University Medical School, Brest, France
    Arthritis Rheum 56:1464-77. 2007
    ..The purpose of this study was to track the repopulation of B cell subsets in PB as well as their subsequent homing into SGs in patients with primary SS treated with rituximab...
  86. ncbi A role for Toll-like receptors in acquired immunity: up-regulation of TLR9 by BCR triggering in naive B cells and constitutive expression in memory B cells
    Nadia L Bernasconi
    Institute for Research in Biomedicine, Bellinzona, Switzerland
    Blood 101:4500-4. 2003
    ..Thus, in human B cells TLRs are downstream of BCR and play a role both in the primary response and in the memory phase...
  87. ncbi Categorical selection of the antibody repertoire in splenic B cells
    Robert L Schelonka
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35233 1530, USA
    Eur J Immunol 37:1010-21. 2007
    ....
  88. ncbi Lupus-specific antiribonucleoprotein B cell tolerance in nonautoimmune mice is maintained by differentiation to B-1 and governed by B cell receptor signaling thresholds
    Y Qian
    Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC 27599, USA
    J Immunol 166:2412-9. 2001
    ..These results suggest a differentiation scheme in which peripheral ignorance to Sm is maintained in mice by the differentiation of anti-Sm B cells to B-1 cells that have increased activation thresholds...
  89. pmc Replication history of B lymphocytes reveals homeostatic proliferation and extensive antigen-induced B cell expansion
    Menno C van Zelm
    Erasmus MC, Department of Immunology, 3015 GE Rotterdam, Netherlands
    J Exp Med 204:645-55. 2007
    ..We quantified the replication history of mouse and human B lymphocyte subsets by calculating the ratio between genomic coding joints and signal joints on kappa-deleting recombination ..
  90. pmc Synovial tissue response to rituximab: mechanism of action and identification of biomarkers of response
    R M Thurlings
    Division of Clinical Immunology and Rheumatology, Academic Medical Center University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Ann Rheum Dis 67:917-25. 2008
    ..To investigate the synovial tissue in patients with rheumatoid arthritis (RA) treated with rituximab and to identify possible predictors of clinical response...
  91. ncbi Anti-CD20 therapy in patients with rheumatoid arthritis: predictors of response and B cell subset regeneration after repeated treatment
    Petra Roll
    University of Wurzburg, Wurzburg, Germany
    Arthritis Rheum 58:1566-75. 2008
    ..The effects on B cell homeostasis after repeated treatments and the relationship of certain B cell subsets to clinical response or relapse are currently not known...
  92. ncbi Diminished peripheral blood memory B cells and accumulation of memory B cells in the salivary glands of patients with Sjögren's syndrome
    Arne Hansen
    University Hospital Charite, Berlin, Germany
    Arthritis Rheum 46:2160-71. 2002
    ..To delineate the mechanism of the abnormalities in B cell biology found in patients with primary Sjögren's syndrome (SS)...
  93. ncbi Mac-1-negative B-1b phenotype of natural antibody-producing cells, including those responding to Gal alpha 1,3Gal epitopes in alpha 1,3-galactosyltransferase-deficient mice
    H Ohdan
    Transplantation Biology Research Center, Surgical Service, Massachusetts General Hospital Harvard Medical School, Boston, MA 02129, USA
    J Immunol 165:5518-29. 2000
    ..They are consistent with a model whereby B-1b cells lose Mac-1 expression upon Ag exposure and that these, rather than plasma cells, become the major IgM Ab-producing cell population...
  94. ncbi Expanded population of activated antigen-engaged cells within the naive B cell compartment of patients with systemic lupus erythematosus
    Nan Hua Chang
    Arthritis Centre of Excellence, Toronto Western Hospital Research Institute, and Department of Medicine, University of Toronto, Ontario, Canada
    J Immunol 180:1276-84. 2008
    ..Although controls also had IgD+IgMlowCD23+ cells, they were reduced in number and not activated. Thus, there is an altered response to Ig receptor engagement with self-Ags in lupus...
  95. doi Redundant role for Zap70 in B cell development and activation
    Farnaz Fallah-Arani
    Division of Immune Cell Biology, MRC National Institute for Medical Research, London, UK
    Eur J Immunol 38:1721-33. 2008
    ..However, we show that Zap70 can rescue the defective positive selection of immature B cells into the recirculating pool in Syk-deficient mice, demonstrating functional redundancy between these two kinases...
  96. ncbi Double-negative T cells, activated by xenoantigen, lyse autologous B and T cells using a perforin/granzyme-dependent, Fas-Fas ligand-independent pathway
    Zhu Xu Zhang
    Department of Surgery, University of Western Ontario, London, Ontario, Canada
    J Immunol 177:6920-9. 2006
    ..In conclusion, this study suggests that xenoreactive DNT cells can control B and T cell responses in perforin/granzyme-dependent mechanisms. DNT cells may be valuable in controlling B and T cell responses in xenotransplantation...
  97. ncbi Impaired germinal center maturation in adenosine deaminase deficiency
    Melissa B Aldrich
    Department of Biochemistry and Molecular Biology, University of Texas Medical School, Houston, TX 77030, USA
    J Immunol 171:5562-70. 2003
    ..The altered splenic environment and signaling abnormalities may concurrently contribute to a block in B cell Ag-dependent maturation in ADA-deficient mouse spleens...
  98. ncbi TLR agonists promote marginal zone B cell activation and facilitate T-dependent IgM responses
    Anatoly V Rubtsov
    Integrated Department of Immunology, University of Colorado Denver and National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Immunol 180:3882-8. 2008
    ..Together, these data demonstrate that in vivo TLR agonist treatment enhances the early production of Ag-specific IgM and activates MZ B cells to promote their relocation...
  99. ncbi Several genes contribute to the production of autoreactive B and T cells in the murine lupus susceptibility locus Sle1c
    Yifang Chen
    Department of Pathology, Immunology, and Laboratory Medicine, Department of Medicine, University of Florida, Gainesville, FL 32610, USA
    J Immunol 175:1080-9. 2005
    ....
  100. ncbi Genetic dissection of systemic lupus erythematosus pathogenesis: partial functional complementation between Sle1 and Sle3/5 demonstrates requirement for intracellular coexpression for full phenotypic expression of lupus
    Masatoshi Wakui
    Department of Medicine and Division of Rheumatology and Clinical Immunology, College of Medicine, University of Florida, Gainesville, FL 32610, USA
    J Immunol 175:1337-45. 2005
    ..Our mixed chimera approach continues to provide novel insights into the functional genetic pathways underlying this important murine model of systemic autoimmunity...
  101. ncbi Modulation of autoimmunity by TLR9 in the chronic graft-vs-host model of systemic lupus erythematosus
    Zhongjie Ma
    Division of Rheumatology, Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104 6160, USA
    J Immunol 177:7444-50. 2006
    ..56R and B6.56R.TLR9(-/-) postinduction of cGVH disease. Taken together, these results suggested that TLR9 may worsen some aspects of systemic autoimmunity while alleviating others...

Research Grants141 found, 100 shown here

  1. IMMUNOLOGIC STUDY OF HUMAN HLA AND MOUSE H-2 ANTIGENS
    D Amos; Fiscal Year: 1980
    ..Effectors will be conjugated to antigen-loaded lipid vesicles with entrapped 6-carboxyfluorescein to isolate a purified effector population using a fluorescence-activated cell sorter. ..
  2. B-Lymphocyte subsets in type I diabetes
    Jin Xiong She; Fiscal Year: 2001
    ..mu/null recipients. Understanding B-lymphocytes control of autoimmunity should provide new avenues toward diabetes, diagnosis, prevention, and treatment. ..
  3. Immune function and the progression to type 1 diabetes
    Mark Atkinson; Fiscal Year: 2001
    ..abstract_text> ..
  4. Immune function and the progression to type 1 diabetes
    Mark Atkinson; Fiscal Year: 2005
    ..abstract_text> ..
  5. Immune function and the progression to type 1 diabetes
    Mark Atkinson; Fiscal Year: 2002
    ..abstract_text> ..
  6. Immune function and the progression to type 1 diabetes
    Mark Atkinson; Fiscal Year: 2003
    ..abstract_text> ..
  7. Immune function and the progression to type 1 diabetes
    Mark Atkinson; Fiscal Year: 2004
    ..abstract_text> ..
  8. LY-1 B CELLS: DEVELOPMENTAL ORIGINS AND V GENE BIASES
    Richard Hardy; Fiscal Year: 2003
    ..abstract_text> ..
  9. IMMUNOGLOBULIN V GENES AND B CELL DEVELOPMENT
    Richard Hardy; Fiscal Year: 2001
    ..The results of these studies will help to establish the types of selection that shape the expressed B cell repertoire, fetally and in the adult, with implications for modulating both normal and autoimmune responses. ..
  10. LY-1 B CELLS: DEVELOPMENTAL ORIGINS AND V GENE BIASES
    Richard Hardy; Fiscal Year: 2001
    ..abstract_text> ..
  11. IMMUNOGLOBULIN V GENES AND B CELL DEVELOPMENT
    Richard Hardy; Fiscal Year: 2000
    ..The results of these studies will help to establish the types of selection that shape the expressed B cell repertoire, fetally and in the adult, with implications for modulating both normal and autoimmune responses. ..
  12. LY-1 B CELLS: DEVELOPMENTAL ORIGINS AND V GENE BIASES
    Richard Hardy; Fiscal Year: 2008
    ....
  13. LY-1 B CELLS--DEVELOPMENTAL ORIGINS AND V GENE
    Richard Hardy; Fiscal Year: 2000
    ..Cumulatively, these studies will provide a clearer picture of fetal and adult B lymphopoiesis and distinguish whether the modes of selection affecting developing B cells are similar or different during these two ontogenic timi s. ..
  14. LY-1 B CELLS: DEVELOPMENTAL ORIGINS AND V GENE BIASES
    Richard Hardy; Fiscal Year: 2004
    ..abstract_text> ..
  15. LY-1 B CELLS: DEVELOPMENTAL ORIGINS AND V GENE BIASES
    Richard Hardy; Fiscal Year: 2007
    ....
  16. LY-1 B CELLS--LINEAGE DETERMINATION/ANTIBODY REPERTOIRE
    Richard Hardy; Fiscal Year: 1992
    ..Specificities encoded by these V genes to be examined in detail will include both anti-thymocyte and anti-bromelain-treated mouse erythrocyte autoantibodies, both distinctively enriched in this population...
  17. BD Biosciences LSR Flow Cytometer
    Richard Hardy; Fiscal Year: 2002
    ..abstract_text> ..
  18. IMMUNOGLOBULIN V GENES AND B CELL DEVELOPMENT
    Richard Hardy; Fiscal Year: 2002
    ..The results of these studies will help to establish the types of selection that shape the expressed B cell repertoire, both fetally and in the adult, with implications for modulating normal and autoimmune responses. ..
  19. LY-1 B CELLS: DEVELOPMENTAL ORIGINS AND V GENE BIASES
    Richard Hardy; Fiscal Year: 2002
    ..abstract_text> ..
  20. IMMUNOGLOBULIN V GENES AND B CELL DEVELOPMENT
    Richard Hardy; Fiscal Year: 2006
    ..The results of these studies will help to establish the types of selection that shape the expressed B cell repertoire, both fetally and in the adult, with implications for modulating normal and autoimmune responses. ..
  21. IMMUNOGLOBULIN V GENES AND B CELL DEVELOPMENT
    Richard Hardy; Fiscal Year: 2005
    ..The results of these studies will help to establish the types of selection that shape the expressed B cell repertoire, both fetally and in the adult, with implications for modulating normal and autoimmune responses. ..
  22. LY-1 B CELLS: DEVELOPMENTAL ORIGINS AND V GENE BIASES
    Richard Hardy; Fiscal Year: 2005
    ..abstract_text> ..
  23. IMMUNOGLOBULIN V GENES AND B CELL DEVELOPMENT
    Richard Hardy; Fiscal Year: 2003
    ..The results of these studies will help to establish the types of selection that shape the expressed B cell repertoire, both fetally and in the adult, with implications for modulating normal and autoimmune responses. ..
  24. IMMUNOGLOBULIN V GENES AND B CELL DEVELOPMENT
    Richard Hardy; Fiscal Year: 2004
    ..The results of these studies will help to establish the types of selection that shape the expressed B cell repertoire, both fetally and in the adult, with implications for modulating normal and autoimmune responses. ..
  25. LY-1 B CELLS: DEVELOPMENTAL ORIGINS AND V GENE BIASES
    Richard R Hardy; Fiscal Year: 2010
    ....
  26. LY-1 B CELLS--DEVELOPMENTAL ORIGINS AND V GENE
    Richard Hardy; Fiscal Year: 1999
    ..Cumulatively, these studies will provide a clearer picture of fetal and adult B lymphopoiesis and distinguish whether the modes of selection affecting developing B cells are similar or different during these two ontogenic timi s. ..
  27. LY-1 B CELLS: DEVELOPMENTAL ORIGINS AND V GENE BIASES
    Richard Hardy; Fiscal Year: 2009
    ....
  28. LY-1 B-CELLS--DEVELOPMENTAL ORIGINS AND V GENE BIASES
    Richard Hardy; Fiscal Year: 1993
    ..This work may eventually help us to understand the relationship of special features of fetal B cell development with autoreactivity nd B cell neoplasia...
  29. IMMUNOGLOBULIN V GENES AND B CELL DEVELOPMENT
    Richard Hardy; Fiscal Year: 1999
    ..The results of these studies will help to establish the types of selection that shape the expressed B cell repertoire, fetally and in the adult, with implications for modulating both normal and autoimmune responses. ..
  30. LY-1 B CELLS--LINEAGE DETERMINATION/ANTIBODY REPERTOIRE
    Richard Hardy; Fiscal Year: 1990
    ..Specificities encoded by these V genes to be examined in detail will include both anti-thymocyte and anti-bromelain-treated mouse erythrocyte autoantibodies, both distinctively enriched in this population...
  31. LY-1 B CELLS--LINEAGE DETERMINATION/ANTIBODY REPERTOIRE
    Richard Hardy; Fiscal Year: 1991
    ..Specificities encoded by these V genes to be examined in detail will include both anti-thymocyte and anti-bromelain-treated mouse erythrocyte autoantibodies, both distinctively enriched in this population...
  32. Transitional B cell selection during peripheral B lymphopenia and reconstitution
    MICHAEL PAUL CANCRO; Fiscal Year: 2010
    ..We will assess whether reduced available BLyS levels will restore normal selective stringency by in vivo treatment with soluble TACI Ig or neutralizing anti-BLyS antibody in normal and autoimmune models. ..
  33. ROLE OF BLYS IN PERIPHERAL B CELL SELECTION AND SURVIVAL
    Michael Cancro; Fiscal Year: 2005
    ..A/WySnJ mice. ..
  34. ROLE OF BLYS IN PERIPHERAL B CELL SELECTION AND SURVIVAL
    Michael Cancro; Fiscal Year: 2004
    ..A/WySnJ mice. ..
  35. B CELL DEFICIENCY IN A/WYSNJ MICE
    Michael Cancro; Fiscal Year: 1999
    ....
  36. Transitional B cell selection during peripheral B lymphopenia and reconstitution
    MICHAEL PAUL CANCRO; Fiscal Year: 2010
    ..We will assess whether reduced available BLyS levels will restore normal selective stringency by in vivo treatment with soluble TACI Ig or neutralizing anti-BLyS antibody in normal and autoimmune models. ..
  37. Transitional B cell selection during peripheral B lymphopenia and reconstitution
    Michael Cancro; Fiscal Year: 2009
    ..We will assess whether reduced available BLyS levels will restore normal selective stringency by in vivo treatment with soluble TACI Ig or neutralizing anti-BLyS antibody in normal and autoimmune models. ..
  38. MECHANISMS OF LYMPHOID LINEAGE COMMITMENT
    David Allman; Fiscal Year: 2004
    ..abstract_text> ..
  39. Development of plasmacytoid dendritic cells
    David Allman; Fiscal Year: 2004
    ..Determine the actual contribution of Rag-2+ lymphoid progenitors to each peripheral DC subset including PDCs; and 3. Identify cytokines that can redirect early B cell progenitors into the DC lineage in vitro and in vivo. ..
  40. MECHANISMS OF LYMPHOID LINEAGE COMMITMENT
    David Allman; Fiscal Year: 2005
    ..abstract_text> ..
  41. ROLE OF BLYS IN PERIPHERAL B CELL SELECTION AND SURVIVAL
    Michael Cancro; Fiscal Year: 2007
    ..The resulting antisera will be assessed for broadly neutralizing activity in vitro using a well-established virus pseudotype assay. [unreadable] [unreadable] [unreadable]..
  42. Aging of Early B Cell Precursors
    David Allman; Fiscal Year: 2008
    ..Together, these studies will enhance our knowledge of stem cell biology and the basis for age-related defects in early lymphocyte development. ..
  43. ROLE OF BLYS IN PERIPHERAL B CELL SELECTION AND SURVIVAL
    Michael Cancro; Fiscal Year: 2008
    ..A/WySnJ mice. ..
  44. Aging of Early B Cell Precursors
    David Allman; Fiscal Year: 2007
    ..Together, these studies will enhance our knowledge of stem cell biology and the basis for age-related defects in early lymphocyte development. ..
  45. Lymphocyte homeostastis & regulation during aging
    Michael Cancro; Fiscal Year: 2006
    ..abstract_text> ..
  46. Lymphocyte homeostastis & regulation during aging
    Michael Cancro; Fiscal Year: 2008
    ..abstract_text> ..
  47. Immune System Development and Regulation
    Michael Cancro; Fiscal Year: 2007
    ..In this regard, the ISDR will foster research and research training that bears directly on control and manipulation of the immune system in health and disease. ..
  48. Development of plasmacytoid dendritic cells
    David Allman; Fiscal Year: 2008
    ..Determine the actual contribution of Rag-2+ lymphoid progenitors to each peripheral DC subset including PDCs; and 3. Identify cytokines that can redirect early B cell progenitors into the DC lineage in vitro and in vivo. ..
  49. ROLE OF BLYS IN PERIPHERAL B CELL SELECTION AND SURVIVAL
    Michael Cancro; Fiscal Year: 2007
    ..A/WySnJ mice. ..
  50. Aging of Early B Cell Precursors
    David M Allman; Fiscal Year: 2010
    ..Together, these studies will enhance our knowledge of stem cell biology and the basis for age-related defects in early lymphocyte development. ..
  51. Transitional B cell selection during peripheral B lymphopenia and reconstitution
    Michael Cancro; Fiscal Year: 2009
    ..We will assess whether reduced available BLyS levels will restore normal selective stringency by in vivo treatment with soluble TACI Ig or neutralizing anti-BLyS antibody in normal and autoimmune models. ..
  52. Aging of Early B Cell Precursors
    David Allman; Fiscal Year: 2009
    ..Together, these studies will enhance our knowledge of stem cell biology and the basis for age-related defects in early lymphocyte development. ..
  53. Development of plasmacytoid dendritic cells
    David Allman; Fiscal Year: 2005
    ..Determine the actual contribution of Rag-2+ lymphoid progenitors to each peripheral DC subset including PDCs; and 3. Identify cytokines that can redirect early B cell progenitors into the DC lineage in vitro and in vivo. ..
  54. Transitional B cell selection during peripheral B lymphopenia and reconstitution
    Michael Cancro; Fiscal Year: 2008
    ..We will assess whether reduced available BLyS levels will restore normal selective stringency by in vivo treatment with soluble TACI Ig or neutralizing anti-BLyS antibody in normal and autoimmune models. ..
  55. Stage-specific Signaling in Peripheral B Cell Selection
    Wasif N Khan; Fiscal Year: 2010
    ..This new knowledge can lead to the development of novel therapeutics for the treatment of B cell-mediated autoimmune diseases and immunodeficiencies and B cell lymphomas. ..
  56. MECHANISMS OF IL-2 IMMUNE ENHANCEMENT IN HUMANS
    Charlotte Cunningham Rundles; Fiscal Year: 2001
    ..Thus, this application will focus on the cellular and molecular mechanisms by which IL-2 reconstitutes T cell immunity in this model system. ..
  57. Suppression and Exacerbation of B and T cell Responses *
    Ignacio Sanz; Fiscal Year: 2007
    ..abstract_text> ..
  58. DIFFERENTIATIVE PROGRAMS OF LYMPHOID PROGENITOR CELLS
    TUCKER LEBIEN; Fiscal Year: 2001
    ..The collective results from these studies will enhance our understanding of the normal developmental program of human B lymphocytes and perturbations in the program that can give rise to leukemia and immunodeficiency. ..
  59. B1B lymphocytes generate T cell-independent memory
    KISHORE ALUGUPALLI; Fiscal Year: 2007
    ..Understanding the basis for the longevity of the Tl protective responses conferred by B1b cells will provide novel approaches to generate effective vaccines against pathogens expressing Tl antigens. ..
  60. Periodontal Assessment in RA Study (PARAS)
    Clifton Bingham; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  61. MEDICAL SCIENTIST TRAINING PROGRAM
    TUCKER LEBIEN; Fiscal Year: 2007
    ....
  62. NAD and CD38: modulators of inflammation and immunity
    Frances Lund; Fiscal Year: 2008
    ..Thus, it is one of NIAID's highest priorities (NOT-AI-05-013) that we develop more effective influenza vaccines that are protective against a wide array of different viral serotypes. ..
  63. Primary Immune Deficiency Consortium Conference
    Charlotte Cunningham Rundles; Fiscal Year: 2007
    ..Principle topics will focus on: Diagnosis of Immunodeficiency; Genetics, Immune Reconstruction, and the Use of Standard and Novel Therapies. ..
  64. Immune control of SIVagm replication in vivo
    JOERN SCHMITZ; Fiscal Year: 2007
    ..3. Assess whether abolishing both cellular and humoral adaptive immune responses will affect the course of SIVagm infection of African green monkeys. [unreadable] [unreadable]..
  65. CD19 TYROSINE MEDIATED SIGNAL TRANSDUCTION IN VIVO
    Robert Carter; Fiscal Year: 2002
    ....
  66. Generation and maintenance of influenza-specific plasma and memory B cells
    Frances Lund; Fiscal Year: 2007
    ..The experiments in this grant will identify the ways in which B cells contribute to immunity to influenza infection and will facilitate the design of more effective vaccines to this important human disease. [unreadable] [unreadable]..
  67. The trout kidney: major immune organ for B cell development and activation.
    Patty Zwollo; Fiscal Year: 2006
    ..As such, this study should add important knowledge in the fields of comparative and evolutionary immunology, as well as areas of autoimmune disease, including lupus and inflammatory kidney disease. [unreadable] [unreadable] [unreadable]..
  68. Generation and maintenance of influenza-specific plasma and memory B cells
    Frances Lund; Fiscal Year: 2008
    ..The experiments in this grant will identify the ways in which B cells contribute to immunity to influenza infection and will facilitate the design of.more effective vaccines to this important human disease. ..
  69. MECHANISMS OF IL-2 IMMUNE ENHANCEMENT IN HUMANS
    Charlotte Cunningham Rundles; Fiscal Year: 1999
    ..Thus, this application will focus on the cellular and molecular mechanisms by which IL-2 reconstitutes T cell immunity in this model system. ..
  70. DIFFERENTIATIVE PROGRAMS OF LYMPHOID PROGENITOR CELLS
    TUCKER LEBIEN; Fiscal Year: 1992
    ..4) Studies are underway to clone the genes encoding gp40/BA-1, p24/BA-2, and gp/100/CACCA/BA-3 using mouse L cell transfection and subtractive hybridization. (LB) ..
  71. Regulation of Humoral Immunity to Influenza Virus
    Nicole Baumgarth; Fiscal Year: 2010
    ..Completion of these studies will contribute to a better understanding of the processes that regulate the induction of protective antiviral B cell responses to influenza virus. Project Description Page 6 ..
  72. Long-lived B cell Immunity in the Respiratory Tract
    Nicole Baumgarth; Fiscal Year: 2010
    ..This basic information will provide potential avenues for rational vaccine design that aims to boost local/mucosal immune responses. ..
  73. Generation and maintenance of influenza-specific plasma and memory B cells
    Frances Lund; Fiscal Year: 2009
    ..The experiments in this grant will identify the ways in which B cells contribute to immunity to influenza infection and will facilitate the design of.more effective vaccines to this important human disease. ..
  74. NAD and CD38: modulators of inflammation and immunity
    Frances E Lund; Fiscal Year: 2010
    ..Thus, it is one of NIAID's highest priorities (NOT-AI-05-013) that we develop more effective influenza vaccines that are protective against a wide array of different viral serotypes. ..
  75. Stage-specific Signaling in Peripheral B Cell Selection
    Wasif N Khan; Fiscal Year: 2010
    ..This new knowledge can lead to the development of novel therapeutics for the treatment of B cell-mediated autoimmune diseases and immunodeficiencies and B cell lymphomas. ..
  76. Stage-specific Signaling in Peripheral B Cell Selection
    Wasif Khan; Fiscal Year: 2008
    ..This new knowledge can lead to the development of novel therapeutics for the treatment of B cell-mediated autoimmune diseases and immunodeficiencies and B cell lymphomas. ..
  77. A Model System for the Study of Human B-cell Tolerance
    Ignacio Sanz; Fiscal Year: 2005
    ..Furthermore, we believe that our results will improve our ability to treat patients with SLE and similar diseases. ..
  78. DIFFERENTIATIVE PROGRAMS OF LYMPHOID PROGENITOR CELLS
    TUCKER LEBIEN; Fiscal Year: 1999
    ....
  79. Identification of Biomarkers in Sjogren's Syndrome
    Ignacio Sanz; Fiscal Year: 2006
    ....
  80. Development of plasmacytoid dendritic cells
    David Allman; Fiscal Year: 2006
    ..Determine the actual contribution of Rag-2+ lymphoid progenitors to each peripheral DC subset including PDCs; and 3. Identify cytokines that can redirect early B cell progenitors into the DC lineage in vitro and in vivo. ..
  81. DIFFERENTIATIVE PROGRAMS OF LYMPHOID PROGENITOR CELLS
    TUCKER LEBIEN; Fiscal Year: 2004
    ..The collective results from these studies will enhance our understanding of the normal developmental program of human B lymphocytes and perturbations in the program that can give rise to leukemia and immunodeficiency. ..
  82. Transcription Regulation by B-Cell Receptor Signaling
    Wasif Khan; Fiscal Year: 2004
    ..Identification of these important missing links may reveal new immunotherapeutic targets for intervention in B-cell deficiency diseases such as XLA. ..
  83. Transcription Regulation by B-Cell Receptor Signaling
    Wasif Khan; Fiscal Year: 2004
    ..Identification of these important missing links may reveal new immunotherapeutic targets for intervention in B-cell deficiency diseases such as XLA. ..
  84. ROLE FOR THE ECTOENZYME CD38 IN IMMUNE RESPONSES
    Frances Lund; Fiscal Year: 2003
    ..These experiments will provide a framework for understanding the elusive role of ecto-enzymes such as CD38 in the generation and maintenance of protective immunity. ..
  85. DIFFERENTIATIVE PROGRAMS OF LYMPHOID PROGENITOR CELLS
    TUCKER LEBIEN; Fiscal Year: 2002
    ..The collective results from these studies will enhance our understanding of the normal developmental program of human B lymphocytes and perturbations in the program that can give rise to leukemia and immunodeficiency. ..
  86. Regulation of Humoral Immunity to Influenza Virus
    Nicole Baumgarth; Fiscal Year: 2002
    ..It would also form the basis for defining the precise molecular mechanisms of early virus-specific B cell activation, thus for identifying possible new targets for rationale vaccine design. ..
  87. CD8 LYMPHOCYTE RESPONSES IN SIV PATHOGENESIS
    JOERN SCHMITZ; Fiscal Year: 2002
    ..Determine the contribution of CD8+ lymphocytes to the loss of CD4+ Tcells following infection by SIVmac or the rapidly CD4+T cell-depleting virus SHIV-KB9. ..
  88. 2002 Summer School in Primary Immunodeficiency Disorders
    Charlotte Cunningham Rundles; Fiscal Year: 2002
    ..Fellows participating in the course will be reimbursed for their travel expenses. No registration fee will be charged for the fellows participating in the program. ..
  89. A Model System for the Study of Human B-cell Tolerance
    Ignacio Sanz; Fiscal Year: 2003
    ..Furthermore, we believe that our results will improve our ability to treat patients with SLE and similar diseases. ..