ductus arteriosus

Summary

Summary: A fetal blood vessel connecting the pulmonary artery with the descending aorta.

Top Publications

  1. pmc Chronic activation of the prostaglandin receptor EP4 promotes hyaluronan-mediated neointimal formation in the ductus arteriosus
    Utako Yokoyama
    Cardiovascular Research Institute, Yokohama City University, Yokohama, Japan
    J Clin Invest 116:3026-34. 2006
  2. ncbi Patent ductus arteriosus and neonatal death in prostaglandin receptor EP4-deficient mice
    E Segi
    Department of Physiological Chemistry, Faculty of Pharmaceutical Sciences, Kyoto University, Japan
    Biochem Biophys Res Commun 246:7-12. 1998
  3. pmc Differential temporal and spatial progerin expression during closure of the ductus arteriosus in neonates
    Regina Bokenkamp
    Department of Pediatric Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    PLoS ONE 6:e23975. 2011
  4. ncbi Mechanisms regulating the ductus arteriosus
    Ronald I Clyman
    School of Medicine, Cardiovascular Research Institute, University of California, San Francisco, Calif, USA
    Biol Neonate 89:330-5. 2006
  5. ncbi The pharmacologic closure of the patent ductus arteriosus
    Bart Van Overmeire
    Department of Pediatrics, Neonatal Intensive Care Unit, Antwerp University Hospital, University of Antwerp, Wilrijkstraat 10, B 2650 Edegem, Belgium
    Semin Fetal Neonatal Med 10:177-84. 2005
  6. ncbi Patency of the ductus arteriosus in the newborn--now you want it, now you don't
    Thor Willy Ruud Hansen
    Pediatr Crit Care Med 8:302-3. 2007
  7. ncbi Multiple transcripts of Ca2+ channel alpha1-subunits and a novel spliced variant of the alpha1C-subunit in rat ductus arteriosus
    Utako Yokoyama
    Dept of Pediatrics, Yokohama City University, Kanazawa Ku, Yokohama 236 0004, Japan
    Am J Physiol Heart Circ Physiol 290:H1660-70. 2006
  8. doi The fate of ductus arteriosus in infants at 23-27 weeks of gestation: from spontaneous closure to ibuprofen resistance
    Carlo Dani
    Department of Surgical and Medical Critical Care, Section of Neonatology, Careggi University Hospital of Florence, Florence, Italy
    Acta Paediatr 97:1176-80. 2008
  9. doi Cytochrome P-450 3A13 and endothelin jointly mediate ductus arteriosus constriction to oxygen in mice
    Barbara Baragatti
    Scuola Superiore Sant Anna, Piazza Martiri della Libertà 33, Pisa 56127, Italy
    Am J Physiol Heart Circ Physiol 300:H892-901. 2011
  10. pmc Prostaglandin E2-activated Epac promotes neointimal formation of the rat ductus arteriosus by a process distinct from that of cAMP-dependent protein kinase A
    Utako Yokoyama
    Cardiovascular Research Institute, Yokohama City University Graduate School of Medicine, Kanagawa, Japan
    J Biol Chem 283:28702-9. 2008

Detail Information

Publications228 found, 100 shown here

  1. pmc Chronic activation of the prostaglandin receptor EP4 promotes hyaluronan-mediated neointimal formation in the ductus arteriosus
    Utako Yokoyama
    Cardiovascular Research Institute, Yokohama City University, Yokohama, Japan
    J Clin Invest 116:3026-34. 2006
    PGE, a potent vasodilator, plays a primary role in maintaining the patency of the ductus arteriosus (DA). Genetic disruption of the PGE-specific receptor EP4, however, paradoxically results in fatal patent DA (PDA) in mice...
  2. ncbi Patent ductus arteriosus and neonatal death in prostaglandin receptor EP4-deficient mice
    E Segi
    Department of Physiological Chemistry, Faculty of Pharmaceutical Sciences, Kyoto University, Japan
    Biochem Biophys Res Commun 246:7-12. 1998
    ..Histological examination revealed that the ductus arteriosus in dead neonates remained open, while it was partially closed in the survivors...
  3. pmc Differential temporal and spatial progerin expression during closure of the ductus arteriosus in neonates
    Regina Bokenkamp
    Department of Pediatric Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    PLoS ONE 6:e23975. 2011
    Closure of the ductus arteriosus (DA) at birth is essential for the transition from fetal to postnatal life. Before birth the DA bypasses the uninflated lungs by shunting blood from the pulmonary trunk into the systemic circulation...
  4. ncbi Mechanisms regulating the ductus arteriosus
    Ronald I Clyman
    School of Medicine, Cardiovascular Research Institute, University of California, San Francisco, Calif, USA
    Biol Neonate 89:330-5. 2006
    A patent ductus arteriosus (PDA) results in increased pulmonary blood flow and redistribution of flow to other organs. Several co-morbidities (i.e...
  5. ncbi The pharmacologic closure of the patent ductus arteriosus
    Bart Van Overmeire
    Department of Pediatrics, Neonatal Intensive Care Unit, Antwerp University Hospital, University of Antwerp, Wilrijkstraat 10, B 2650 Edegem, Belgium
    Semin Fetal Neonatal Med 10:177-84. 2005
    The ductus arteriosus is a fetal vessel that allows most of the blood leaving the right ventricle of the heart to bypass the lungs...
  6. ncbi Patency of the ductus arteriosus in the newborn--now you want it, now you don't
    Thor Willy Ruud Hansen
    Pediatr Crit Care Med 8:302-3. 2007
  7. ncbi Multiple transcripts of Ca2+ channel alpha1-subunits and a novel spliced variant of the alpha1C-subunit in rat ductus arteriosus
    Utako Yokoyama
    Dept of Pediatrics, Yokohama City University, Kanazawa Ku, Yokohama 236 0004, Japan
    Am J Physiol Heart Circ Physiol 290:H1660-70. 2006
    ..consist of multiple subtypes, regulate vascular tone in developing arterial smooth muscle, including the ductus arteriosus (DA). First, we examined the expression of VDCC subunits in the Wistar rat DA during development...
  8. doi The fate of ductus arteriosus in infants at 23-27 weeks of gestation: from spontaneous closure to ibuprofen resistance
    Carlo Dani
    Department of Surgical and Medical Critical Care, Section of Neonatology, Careggi University Hospital of Florence, Florence, Italy
    Acta Paediatr 97:1176-80. 2008
    Some extremely preterm infants experience spontaneous closure of the ductus arteriosus. On the other side, a high percentage (22-30%) of preterm infants born at the lower gestational age fail to respond to a single course of ibuprofen.
  9. doi Cytochrome P-450 3A13 and endothelin jointly mediate ductus arteriosus constriction to oxygen in mice
    Barbara Baragatti
    Scuola Superiore Sant Anna, Piazza Martiri della Libertà 33, Pisa 56127, Italy
    Am J Physiol Heart Circ Physiol 300:H892-901. 2011
    The fetal ductus arteriosus (DA) contracts to oxygen, and this feature, maturing through gestation, is considered important for its closure at birth...
  10. pmc Prostaglandin E2-activated Epac promotes neointimal formation of the rat ductus arteriosus by a process distinct from that of cAMP-dependent protein kinase A
    Utako Yokoyama
    Cardiovascular Research Institute, Yokohama City University Graduate School of Medicine, Kanagawa, Japan
    J Biol Chem 283:28702-9. 2008
    ..protein kinase A (PKA) signal pathway plays a critical role in intimal cushion formation in perinatal ductus arteriosus (DA) through promoting synthesis of hyaluronan...
  11. ncbi Morphometric study of the ductus arteriosus during human development
    Michał Szpinda
    Department of Normal Anatomy, Ludwig Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Karłowicza 24 Street, 85 092 Bydgoszcz, Poland
    Ann Anat 189:47-52. 2007
    During prenatal life, the ductus arteriosus connects the left pulmonary artery and the descending aorta...
  12. pmc Cyclooxygenase-1-selective inhibition prolongs gestation in mice without adverse effects on the ductus arteriosus
    Charles D Loftin
    Laboratory of Environmental Carcinogenesis and Mutagenesis, National Institutes of Health, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    J Clin Invest 110:549-57. 2002
    ..but their use is limited by serious complications to the fetus and neonate, including adverse effects on the ductus arteriosus (DA)...
  13. doi Failure of ductus arteriosus closure is associated with increased mortality in preterm infants
    Shahab Noori
    Department of Pediatrics, Neonatal Perinatal Medicine, Children s Hospital, Oklahoma City, OK, USA
    Pediatrics 123:e138-44. 2009
    Because the standard of care has been to attempt to close the patent ductus arteriosus in preterm neonates, there is a paucity of information on the outcome of patients with a persistent patent ductus arteriosus...
  14. pmc Failure of postnatal ductus arteriosus closure in prostaglandin transporter-deficient mice
    Hee Yoon Chang
    Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Circulation 121:529-36. 2010
    Prostaglandin E(2) (PGE(2)) plays a major role both in maintaining patency of the fetal ductus arteriosus and in closure of the ductus arteriosus after birth...
  15. ncbi Comparative anatomy and ontogeny of the ductus arteriosus, a vascular outsider
    M Bergwerff
    Department of Anatomy and Embryology, Leiden University Medical Centre, P O Box 9602, 2300 RC Leiden, The Netherlands
    Anat Embryol (Berl) 200:559-71. 1999
    In its function of separating pulmonary and systemic arterial blood flow, the ductus arteriosus, which connects both circuits, either closes permanently at a certain stage in development or attains a capacity to close and reopen ..
  16. doi Effects of sex and estrogen on chicken ductus arteriosus reactivity
    Thijs W H Flinsenberg
    Department of Pediatrics, Maastricht University Medical Center, GROW School for Oncology and Developmental Biology, P Debyelaan 25, Maastricht, The Netherlands
    Am J Physiol Regul Integr Comp Physiol 298:R1217-24. 2010
    ..In the present study we hypothesized 1) the presence of sexual dimorphism in chicken ductus arteriosus (DA) responsiveness to contractile and relaxant stimuli and 2) that estrogens are vasoactive in the chicken ..
  17. ncbi Congenital ductus arteriosus aneurysm presenting with stridor in a newborn
    Bibhuti B Das
    Department of Pediatrics, Lincoln Medical and Mental Health Center, 234 East 149th Street, Bronx, NY, USA
    J Perinatol 22:179-80. 2002
  18. doi Response of chicken ductus arteriosus to hypercarbic and normocarbic acidosis
    Rob M J Moonen
    Department of Pediatrics, School for Oncology and Developmental Biology GROW, Maastricht University Medical Center, Maastricht, The Netherlands
    Neonatology 98:47-56. 2010
    Changes in pH can have profound effects on vascular tone and reactivity, but their influence on the ductus arteriosus (DA) remains unknown.
  19. pmc Acute Ortner's syndrome arising from ductus arteriosus aneurysm
    John Kokotsakis
    Department of Cardiac Surgery, Evangelismos General Hospital, 10676 Athens, Greece
    Tex Heart Inst J 35:216-7. 2008
  20. ncbi Isolated neonatal ductus arteriosus aneurysm
    Sheng Ling Jan
    Division of Pediatric Cardiology, Department of Pediatrics, Taichung Veterans General Hospital, Taichung, Taiwan
    J Am Coll Cardiol 39:342-7. 2002
    A prospective study was performed to evaluate the incidence, clinical manifestations and outcome of ductus arteriosus aneurysm (DAA) in full-term neonates.
  21. ncbi Fetal hydrops associated with spontaneous premature closure of ductus arteriosus
    Takeshi Kondo
    Division of Molecular Pathology, Department of Biomedical Informatics, Kobe University Graduate School of Medicine, Kobe, Japan
    Pathol Int 56:554-7. 2006
    ..The autopsy revealed an enlarged heart and aortic coarctation in the region of the ductus arteriosus. A mild form of aortic coarctation and premature closure of the ductus arteriosus with fibrous thickening of ..
  22. ncbi Congenital ductus arteriosus aneurysm
    Lisa K Hornberger
    J Am Coll Cardiol 39:348-50. 2002
  23. ncbi Ontogeny of chicken ductus arteriosus response to oxygen and vasoconstrictors
    Pia Agren
    Department of Pediatrics, Maastricht University Hospital, Research Institute Growth and Development GROW, University of Maastricht, Maastricht, The Netherlands
    Am J Physiol Regul Integr Comp Physiol 292:R485-96. 2007
    The present study aimed to characterize the contractile reactivity of the chicken ductus arteriosus (DA) from the last stage of prenatal development and throughout the perinatal period...
  24. ncbi Prevalence of spontaneous closure of the ductus arteriosus in neonates at a birth weight of 1000 grams or less
    Josh Koch
    Division of Neonatal Perinatal Medicine, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Pediatrics 117:1113-21. 2006
    b>Ductus arteriosus (DA) closure occurs within 96 hours in >95% of neonates >1500 g in birth weight (BW)...
  25. pmc The role of patent ductus arteriosus ligation in bronchopulmonary dysplasia: reexamining a randomized controlled trial
    Ronald Clyman
    Cardiovascular Research Institute and Department of Pediatrics, University of California, San Francisco, CA 94143 0544, USA
    J Pediatr 154:873-6. 2009
    ..To reexamine data from a randomized controlled trial of prophylactic ductus ligation to determine whether ligation contributes directly to the development of bronchopulmonary dysplasia (BPD) in extremely low birth weight infants...
  26. ncbi Regulation of vascular tone and remodeling of the ductus arteriosus
    Utako Yokoyama
    Cardiovascular Research Institute, Yokohama City University Graduate School of Medicine
    J Smooth Muscle Res 46:77-87. 2010
    The ductus arteriosus (DA), a fetal arterial connection between the main pulmonary artery and the descending aorta, normally closes immediately after birth. The DA is a normal and essential fetal structure...
  27. doi Endothelium-dependent contraction induced by acetylcholine in the chicken ductus arteriosus involves cyclooxygenase-1 activation and TP receptor stimulation
    Marijn J Schuurman
    Department of Pediatrics, Maastricht University Medical Center MUMC, School for Oncology and Developmental Biology GROW, Maastricht, 6202 AZ, The Netherlands
    Comp Biochem Physiol A Mol Integr Physiol 157:28-34. 2010
    ..We aimed to determine whether ACh evokes the release of an EDCF in the chicken ductus arteriosus (DA) and to identify its nature...
  28. ncbi Magnetic resonance imaging of ductus arteriosus Botalli apertus in adulthood
    M Schmidt
    Klinik und Poliklinik für Nuklearmedizin der Universität zu Köln, Cologne, Germany matthias
    Int J Cardiol 68:225-9. 1999
    b>Ductus arteriosus Botalli apertus is a congenital cardiovascular malformation usually diagnosed in childhood by echocardiography and/or cardiac catheterization...
  29. pmc Transcriptional regulation during development of the ductus arteriosus
    Kathryn N Ivey
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, USA
    Circ Res 103:388-95. 2008
    The ductus arteriosus is a specialized blood vessel containing highly differentiated and contractile vascular smooth muscle, derived largely from neural crest cells, that is essential for fetal life but typically closes after birth...
  30. pmc Patterns of gene expression in the ductus arteriosus are related to environmental and genetic risk factors for persistent ductus patency
    Nahid Waleh
    Pharmaceutical Discovery Division, SRI International, Menlo Park, California 94025, USA
    Pediatr Res 68:292-7. 2010
    ..exposure, and presence of the rs2817399(A) allele of the gene TFAP2B) are associated with patent ductus arteriosus (PDAs) that fail to close during prostaglandin inhibition...
  31. ncbi The chicken embryo as a model for ductus arteriosus developmental biology: cracking into new territory
    Gopinath Sutendra
    Am J Physiol Regul Integr Comp Physiol 292:R481-4. 2007
  32. ncbi Platelets contribute to postnatal occlusion of the ductus arteriosus
    Katrin Echtler
    Deutsches Herzzentrum, Klinik für Herz und Kreislauferkrankungen, Technische Universitat, Munich, Germany
    Nat Med 16:75-82. 2010
    The ductus arteriosus (DA) is a fetal shunt vessel between the pulmonary artery and the aorta that closes promptly after birth. Failure of postnatal DA closure is a major cause of morbidity and mortality particularly in preterm neonates...
  33. ncbi O2 sensing in the human ductus arteriosus: regulation of voltage-gated K+ channels in smooth muscle cells by a mitochondrial redox sensor
    Evangelos D Michelakis
    Cardiology Division and the Vascular Biology Group, Department of Medicine, University of Alberta, Alberta, Canada
    Circ Res 91:478-86. 2002
    Functional closure of the human ductus arteriosus (DA) is initiated within minutes of birth by O2 constriction. It occurs by an incompletely understood mechanism that is intrinsic to the DA smooth muscle cell (DASMC)...
  34. ncbi Oxygen-sensitive Kv channel gene transfer confers oxygen responsiveness to preterm rabbit and remodeled human ductus arteriosus: implications for infants with patent ductus arteriosus
    Bernard Thebaud
    Vascular Biology Group, University of Alberta, Edmonton, Alberta, Canada
    Circulation 110:1372-9. 2004
    ..At birth, initial functional closure of the ductus arteriosus (DA) results from O2-induced vasoconstriction...
  35. ncbi Idiopathic constriction of the fetal ductus arteriosus
    T N Trevett
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7516, USA
    Ultrasound Obstet Gynecol 23:517-9. 2004
    Constriction of the ductus arteriosus in the fetus is well studied, but mostly secondary to maternal exposure to indomethacin or other non-steroidal anti-inflammatory medications, or structural cardiac lesions...
  36. ncbi Initial results and medium-term follow-up of stent implantation of patent ductus arteriosus in duct-dependent pulmonary circulation
    Mazeni Alwi
    National Heart Institute, Kuala Lumpur, Malaysia
    J Am Coll Cardiol 44:438-45. 2004
    This study was designed to assess the safety, efficacy, medium-term outcome, and complications of patent ductus arteriosus (PDA) stenting in duct-dependent pulmonary circulation.
  37. ncbi Infective aortitis associated with the nonpatent remnant of a ductus arteriosus
    Walter J Flapper
    Tasmanian Cardiothoracic Unit, Royal Hobart Hospital, Tasmania, Australia
    Ann Thorac Surg 76:931-3. 2003
    ..We describe the successful excision of an infected, nonpatent remnant of the ductus arteriosus.
  38. ncbi Developmental changes in endothelium-dependent relaxation of the chicken ductus arteriosus
    P Agren
    Department of Pediatrics, Maastricht University Hospital, Research Institute Growth and Development, University of Maastricht, Maastricht, The Netherlands
    J Physiol Pharmacol 59:55-76. 2008
    We tested the hypothesis that endothelium-dependent relaxation in the chicken ductus arteriosus (DA) is developmentally regulated...
  39. ncbi Oxygen activates the Rho/Rho-kinase pathway and induces RhoB and ROCK-1 expression in human and rabbit ductus arteriosus by increasing mitochondria-derived reactive oxygen species: a newly recognized mechanism for sustaining ductal constriction
    Hidemi Kajimoto
    Vascular Biology Group, Alberta Cardiovascular and Stroke Research Centre ABACUS, University of Alberta, Edmonton, Canada
    Circulation 115:1777-88. 2007
    Constriction of the ductus arteriosus (DA) is initiated at birth by inhibition of O2-sensitive K+ channels in DA smooth muscle cells...
  40. ncbi [Aneurysm of the diverticulum of the ductus arteriosus in the adult with left pneumonectomy; report of a case]
    T Jinno
    Department of Cardiovascular Surgery, Kagawa Prefectural Central Hospital, Takamatsu, Japan
    Kyobu Geka 55:803-6. 2002
    ..Chest computed tomography (CT) scan and aortogram indicated a diagnosis of aneurysm of diverticulum of the ductus arteriosus. Aneurysm of the diverticulum of the ductus arteriosus in the adult is rare...
  41. ncbi Intrauterine ductus arteriosus constriction: analysis of a historic cohort of 20 cases
    Stelamaris Luchese
    Fundação Universitária de Cardiologia, Instituto de Cardiologia do Rio Grande do Sul, Porto Alegre, RS, Brazil
    Arq Bras Cardiol 81:405-10, 399-404. 2003
    ..To describe the relative incidence, presentation, and evolvement of fetuses with early ductus constriction...
  42. ncbi Developmental absence of the O2 sensitivity of L-type calcium channels in preterm ductus arteriosus smooth muscle cells impairs O2 constriction contributing to patent ductus arteriosus
    Bernard Thebaud
    Department of Pediatrics, Division of Neonatology, University of Alberta, Edmonton, T6G 2J3, AB, Canada
    Pediatr Res 63:176-81. 2008
    Patent ductus arteriosus (PDA) complicates the hospital course of premature infants...
  43. ncbi [Diverticulum of the ductus arteriosus. Cause of traumatic aortic ruptures?]
    T Vogler
    Abteilung für Kinderpathologie, Johannes Gutenberg Universitat Mainz, Langenbeckstrasse 1, 55101 Mainz
    Chirurg 78:47-51. 2007
    According to angiographic studies 9-26% of all adult aortae show a ductus arteriosus diverticulum (DAD), i.e. an indention of the aortic wall at the insertion of the obliterated ductus arteriosus...
  44. ncbi Ibuprofen pharmacokinetics in preterm infants with patent ductus arteriosus
    B Van Overmeire
    Department of Pediatrics, Division of Neonatology, University Hospital Antwerp, Wilrijkstreet 10, B2650 Edegem, Belgium
    Clin Pharmacol Ther 70:336-43. 2001
    OBJECTIVE: Our objective was to study the pharmacokinetics of ibuprofen in premature infants with patent ductus arteriosus on day 3 and day 5 after birth...
  45. ncbi Ductus arteriosus aneurysm with community-acquired methicillin-resistant Staphylococcus aureus infection and spontaneous rupture: a potentially fatal quandary
    Audra Stewart
    Cardiology Division, Department of Pediatrics, University of Arkansas for Medical Sciences, College of Medicine, Children s Hospital, Little Rock, Arkansas 72202, USA
    Pediatrics 117:e1259-62. 2006
    ..Comprehensive evaluation discovered a ductus arteriosus aneurysm and pericardial effusion with methicillin-resistant Staphylococcus aureus bacteremia...
  46. ncbi Increased constriction of the ductus arteriosus by dexamethasone, indomethacin, and rofecoxib in fetal rats
    Takeshi Takami
    Department of Pediatrics, Tokyo Medical University, Japan
    Circ J 69:354-8. 2005
    To find a better treatment for patent ductus arteriosus (PDA) in premature infants, the present study investigated the synergism of clinical doses of dexamethasone, indomethacin, and rofecoxib, a selective cyclooxygenase-2 (COX-2) ..
  47. pmc Dynamic changes in the direction of blood flow through the ductus arteriosus at birth
    Kelly J Crossley
    Department of Physiology, PO Box 13F, Monash University, VIC 3800, Australia
    J Physiol 587:4695-704. 2009
    ..Major cardiovascular changes occur at birth, including increased pulmonary blood flow (PBF) and closure of the ductus arteriosus (DA), which acts as a low resistance shunt between the fetal pulmonary and systemic circulations...
  48. doi Maturation of O2 sensing and signaling in the chicken ductus arteriosus
    Angel l Cogolludo
    Dept of Pharmacology, School of Medicine, Universidad Complutense Madrid, Ciudad Universitaria s n, 28040 Madrid, Spain
    Am J Physiol Lung Cell Mol Physiol 297:L619-30. 2009
    The increase in O(2) tension after birth is a major factor stimulating ductus arteriosus (DA) constriction and closure...
  49. ncbi Nonsteroidal antiinflammatory drugs during third trimester and the risk of premature closure of the ductus arteriosus: a meta-analysis
    Gideon Koren
    Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, Toronto, ON, Canada
    Ann Pharmacother 40:824-9. 2006
    ..An evaluation of the risk of premature closure of the ductus arteriosus is useful in determining the safety of NSAIDs at different stages of pregnancy.
  50. doi Morphological and functional alterations of the ductus arteriosus in a chicken model of hypoxia-induced fetal growth retardation
    Saskia Van der Sterren
    Department of Pediatrics, Maastricht University Medical Centre, GROW School for Oncology and Developmental Biology, 6202 AZ Maastricht, The Netherlands
    Pediatr Res 65:279-84. 2009
    ..with intrauterine growth retardation (IUGR) develop are hypothesized to alter the development of the ductus arteriosus (DA). We aimed to evaluate the effects of in ovo hypoxia on chicken DA morphometry and reactivity...
  51. doi Mechanisms mediating the oxygen-induced vasoreactivity of the ductus arteriosus in the chicken embryo
    Henry Greyner
    Department of Biological Science, University of North Texas, Denton, Texas 76203 5017, USA
    Am J Physiol Regul Integr Comp Physiol 295:R1647-59. 2008
    The avian embryo provides a novel model for studying the ductus arteriosus (DA) during the transition from in ovo to ex ovo life...
  52. doi Developmental changes in the effects of prostaglandin E2 in the chicken ductus arteriosus
    Pia Agren
    Department of Pediatrics, Maastricht University Medical Center, Research Institute Growth and Development GROW, University Hospital Maastricht, P Debyelaan 25, P O Box 5800, 6202 AZ Maastricht, The Netherlands
    J Comp Physiol B 179:133-43. 2009
    Prostaglandin E(2) (PGE(2)) is the major vasodilator prostanoid of the mammalian ductus arteriosus (DA)...
  53. ncbi Role of store-operated calcium channels and calcium sensitization in normoxic contraction of the ductus arteriosus
    Zhigang Hong
    Department of Medicine, VA Medical Center and University of Minnesota, Minneapolis, MN 55417, USA
    Circulation 114:1372-9. 2006
    At birth, the increase in oxygen causes contraction of the ductus arteriosus, thus diverting blood flow to the lungs...
  54. ncbi Changing expression of cyclooxygenases and prostaglandin receptor EP4 during development of the human ductus arteriosus
    Cornelia Rheinlaender
    Department of Neonatology, Charite Universitatsmedizin Berlin, Campus Virchow Hospital, 13353 Berlin, Germany
    Pediatr Res 60:270-5. 2006
    Programmed proliferative degeneration of the human fetal ductus arteriosus (DA) in preparation for its definite postnatal closure has a large developmental variability and is controlled by several signaling pathways, most prominently by ..
  55. ncbi Metabolism of PGE2 by prostaglandin dehydrogenase is essential for remodeling the ductus arteriosus
    Kenneth G Coggins
    Department of Medicine, University of North Carolina, Chapel Hill, USA
    Nat Med 8:91-2. 2002
  56. ncbi Challenges encountered during closure of patent ductus arteriosus
    P Ewert
    Department of Congenital Heart Diseases, German Heart Institute Berlin, Augustenburger Platz 1, 13353, Berlin, Germany
    Pediatr Cardiol 26:224-9. 2005
    Transcatheter closure of patent ductus arteriosus (PDA) was one of the first interventions established in invasive cardiology and is now more than 30 years old...
  57. ncbi Patent ductus arteriosus
    Douglas J Schneider
    University of Illinois College of Medicine at Peoria, and Cardiac Catheterization Laboratory, Children s Hospital of Illinois, 420 NE Glen Oak Ave, Suite 304, Peoria, IL 61603, USA
    Circulation 114:1873-82. 2006
  58. pmc The paradoxical patent ductus arteriosus
    Kathryn N Ivey
    Gladstone Institute of Cardiovascular Disease, University of California San Francisco, San Francisco, California 94158, USA
    J Clin Invest 116:2863-5. 2006
    The ductus arteriosus (DA) is a vessel whose patency is required for fetal survival but is incompatible with postnatal life...
  59. ncbi Loss of function of the Prx1 and Prx2 homeobox genes alters architecture of the great elastic arteries and ductus arteriosus
    M Bergwerff
    Department of Anatomy and Embryology, Leiden University Medical Centre, P O Box 9602, 2300 RC Leiden, The Netherlands
    Virchows Arch 436:12-9. 2000
    ..an abnormal positioning and awkward curvature of the aortic arch in addition to a misdirected and elongated ductus arteriosus, and in two of seven combined mutants, an anomalous retro-oesophageal right subclavian artery...
  60. pmc Failure of ductus arteriosus closure and remodeling in neonatal mice deficient in cyclooxygenase-1 and cyclooxygenase-2
    C D Loftin
    Laboratory of Environmental Carcinogenesis and Mutagenesis, Comparative Medicine Branch, National Institutes of Health, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Proc Natl Acad Sci U S A 98:1059-64. 2001
    ..One dramatic change that occurs is the closure and remodeling of the ductus arteriosus (DA), an arterial connection in the fetus that directs blood flow away from the pulmonary circulation...
  61. ncbi Prenatal constriction of the fetal ductus arteriosus--related to maternal pain medication?
    B Schiessl
    Department of Obstetrics and Gynecology, Fetal Medicine Unit, Ludwig Maximilians Universitat, Munich, Germany
    Z Geburtshilfe Neonatol 209:65-8. 2005
    Physiological fetal circulation requires patency of the ductus arteriosus. As gestation proceeds, the sensitivity of the ductus to dilating prostaglandins diminishes...
  62. ncbi Treatment of an aneurysmal dilatation of the ductus arteriosus with indomethacin in a premature infant
    C Doege
    Abteilung IV, Neontaologie, Universitätsklinik für Kinder und Jugendmeizin, Im Neuenheimer Feld 153, 69120, Heidelberg, Germany
    Pediatr Cardiol 27:166-7. 2006
    A large ductus arteriosus aneurysm can lead to potentially serious and life-threatening complications...
  63. ncbi Premature closure of the ductus arteriosus: variable response among monozygotic twins after in utero exposure to indomethacin
    Bahig M Shehata
    Children s Healthcare of Atlanta at Egleston, Department of Pathology, Emory University, Atlanta, Georgia 30322, USA
    Fetal Pediatr Pathol 25:151-7. 2006
    ..by administration of the drug to the mother may cause many side effects, including premature closure of the ductus arteriosus. Hypoxia is a predisposing factor for premature ductal closure and often occurs after maternal indomethacin ..
  64. ncbi Nitric oxide-endothelin-1 interactions after acute ductal constriction in fetal lambs
    Boaz Ovadia
    Department of Pediatrics, University of California, San Francisco, California 94143 0106, USA
    Am J Physiol Heart Circ Physiol 282:H862-71. 2002
    Acute partial compression of the fetal ductus arteriosus (DA) results in an initial increase in pulmonary blood flow (PBF) that is followed by acute vasoconstriction...
  65. ncbi A proposal of new therapeutic strategy for antenatally diagnosed congenital diaphragmatic hernia
    Noboru Inamura
    Department of Pediatric Cardiology, Osaka Medical Center and Research Institute for Maternal and Child Health, Osaka 594 1101, Japan
    J Pediatr Surg 40:1315-9. 2005
    ..The authors reviewed their new therapeutic strategy of ADCDH from a viewpoint of cardiologic function...
  66. ncbi Fetal aortic isthmus growth and morphology in late gestation
    M Nomiyama
    Department of Obstetrics and Gynecology, Saga Prefectural Hospital Kouseikan, Saga, Japan
    Ultrasound Obstet Gynecol 19:153-7. 2002
    ..To establish normal values for fetal aortic isthmus diameter in late gestation and to identify any changes in aortic isthmus dimensions and morphology in pathological conditions...
  67. ncbi [Spontaneus ductal closure in a fetus postnatally diagnosed as Adams-Olivier syndrome]
    Agata Włoch
    Oddzial Kliniczny Połoznictwa i Ginekologii, Slaska Akademia Medyczna
    Ginekol Pol 77:629-33. 2006
    ..Premature ductal closure was diagnosed. Fetal echocardiogram showed absent flow in the ductus arteriosus, dilated right ventricle with decreased function, and moderate tricuspid and pulmonary valve insufficiency ..
  68. ncbi Fetal echocardiographic diagnosis of isolated ductus arteriosus aneurysm: a longitudinal study from 32 weeks of gestation to term
    J J Tseng
    Institute of Clinical Medicine, National Yang Ming University, Taipei, Taiwan
    Ultrasound Obstet Gynecol 26:50-6. 2005
    To investigate the echocardiographic characteristics of isolated fetal ductus arteriosus aneurysm (DAA) and the factors influencing its development.
  69. ncbi Severe heart failure due to ductal constriction caused by maternal indomethacin
    Kyosuke Mushiake
    Department of Pediatrics, Toki General Hospital, Toki, Japan
    Pediatr Int 44:174-6. 2002
  70. ncbi Inhibition of 20-HETE abolishes the myogenic response during NOS antagonism in the ovine fetal pulmonary circulation
    Thomas A Parker
    Pediatric Heart Lung Center, University of Colorado School of Medicine, Denver, Colorado 80045, USA
    Am J Physiol Lung Cell Mol Physiol 289:L261-7. 2005
    ..inhibitor of 20-HETE production, on the pulmonary vasoconstriction caused by acute compression of the ductus arteriosus (DA) in chronically prepared fetal sheep...
  71. ncbi Prenatal detection of ductal-dependent congenital heart disease: how can things be made easier?
    F Vinals
    Ultrasound Department, Clínica Sanatorio Alemán, Concepcion, Chile
    Ultrasound Obstet Gynecol 19:246-9. 2002
    ..detection of ductal dependence in fetuses with severe anomalies of the outflow tracts by observing, with directional power Doppler, reverse flow through the aortic arch or ductus arteriosus in a transverse view of the upper mediastinum.
  72. ncbi Severe ductal constriction in the third-trimester fetus following maternal self-medication with nimesulide
    D Paladini
    Fetal Cardiology Unit, Department of Gynecology and Obstetrics, University Federico II, Naples, Italy
    Ultrasound Obstet Gynecol 25:357-61. 2005
    This was a multicenter series of 10 cases of constriction of the fetal ductus arteriosus occurring after maternal ingestion of one or two oral doses of nimesulide, which led to emergency delivery in four cases.
  73. ncbi The effects of indomethacin tocolysis on the postnatal response of the ductus arteriosus to indomethacin in extremely low birth weight infants
    L Cordero
    Division of Neonatal Perinatal Medicine, Department of Pediatrics, The Ohio State University Medical Center, Columbus, OH 43210 1228, USA
    J Perinatol 27:22-7. 2007
    Antenal indomethacin reportedly decreases the responses of a symptomatic patent ductus arteriosus (sPDA) to postnatal indomethacin treatment. Whether a similar exposure affects the responses to indomethacin prophylaxis is unknown.
  74. pmc Indomethacin promotes nitric oxide function in the ductus arteriosus in the mouse
    D Sodini
    Scuola Superiore Sant Anna, Pisa, Italy
    Br J Pharmacol 153:1631-40. 2008
    Prenatal patency of ductus arteriosus is maintained by prostaglandin (PG) E(2) in concert with nitric oxide (NO) and carbon monoxide (CO). Accordingly, we have previously found that NO activity increases upon deletion of either COX...
  75. ncbi The prostaglandin receptor EP4 triggers remodelling of the cardiovascular system at birth
    M Nguyen
    Department of Medicine, University of North Carolina at Chapel Hill, 27599 7248, USA
    Nature 390:78-81. 1997
    Survival of newborn placental mammals depends on closure of the ductus arteriosus (DA), an arterial connection in the fetus which directs blood away from the pulmonary circulation and towards the placenta where oxygenation occurs...
  76. pmc Function of cyclo-oxygenase-1 and cyclo-oxygenase-2 in the ductus arteriosus from foetal lamb: differential development and change by oxygen and endotoxin
    F Coceani
    Integrative Biology Programme, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
    Br J Pharmacol 132:241-51. 2001
    1. Prenatal patency of the ductus arteriosus is maintained mainly by prostaglandin(PG) E(2)...
  77. ncbi Characterization of PGE2 receptors in fetal and newborn lamb ductus arteriosus
    A Bouayad
    Departments of Cardiology, Pediatrics, and Physiology, , Quebec H3T 1C5, Canada
    Am J Physiol Heart Circ Physiol 280:H2342-9. 2001
    Although the role of PGE2 in maintaining ductus arteriosus (DA) patency is well established, the specific PGE2 receptor subtype(s) (EP) involved have not been clearly identified...
  78. ncbi Effects of phosphodiesterase 5 inhibitor on pulmonary vascular reactivity in the fetal lamb
    Sophie Jaillard
    Department of Surgery, Polyclinique du Bois, Lille, France
    Ann Thorac Surg 81:935-42. 2006
    ..Sildenafil is a selective phosphodiesterase-5 (PDE5) inhibitor. The purpose of the study is to assess the effects of sildenafil on pulmonary vascular circulation during the perinatal period...
  79. ncbi Gene expression in ductus arteriosus and aorta: comparison of birth and oxygen effects
    Mario Costa
    Institute of Neuroscience, Consiglio Nazionale delle Ricerche, Pisa, Italy
    Physiol Genomics 25:250-62. 2006
    b>Ductus arteriosus (DA) closure is initiated by oxygen rise postnatally and progresses in two, functional-to-permanent, stages...
  80. ncbi The effect of vitamin A on contraction of the ductus arteriosus in fetal rat
    G R Wu
    Department of Pediatric Cardiology, The Heart Institute of Japan, Tokyo Women's Medical University, Tokyo, 162 Japan
    Pediatr Res 49:747-54. 2001
    Endogenous retinoic acid may play a role in inducing smooth muscle differentiation in the fetal ductus arteriosus. Maternal administration of retinoic acid may accelerate the process...
  81. ncbi Aneurysmal dilatation of the ductus arteriosus in a neonate
    B L Siu
    The Lillie Frank Abercrombie Division of Pediatric Cardiology and Department of Pediatrics, Texas Children's Hospital, Baylor College of Medicine, Houston, TX 77030, USA
    Pediatr Cardiol 22:403-5. 2001
    ..We report a case of aneurysmal dilatation of a patent ductus arteriosus detected in utero and subsequently confirmed by transthoracic echocardiography in the neonatal period...
  82. ncbi Z-scores of the fetal aortic isthmus and duct: an aid to assessing arch hypoplasia
    L Pasquini
    Institute of Reproductive and Developmental Biology, Faculty of Medicine, Imperial College, Queen Charlotte s and Chelsea Hospital, London, UK
    Ultrasound Obstet Gynecol 29:628-33. 2007
    ..The aim of our study was to develop Z-scores for the aortic isthmus in normal fetuses as a reference for fetuses with suspected coarctation...
  83. ncbi In vivo dilatation of the fetal and postnatal ductus arteriosus by inhibition of phosphodiesterase 3 in rats
    Katsuaki Toyoshima
    Department of Pediatric Cardiology, Tokyo Women s Medical University, Tokyo, Japan
    Biol Neonate 89:251-6. 2006
    Clinically, it appears that phosphodiesterase 3 (PDE 3) inhibitors, which are used for acute cardiac failure in premature infants, dilate the ductus arteriosus (DA).
  84. ncbi Combined treatment with a nonselective nitric oxide synthase inhibitor (l-NMMA) and indomethacin increases ductus constriction in extremely premature newborns
    Roberta L Keller
    Department of Pediatrics, Cardiovascular Research Institute, Pharmacy, University of California San Francisco, CA 94143, USA
    Pediatr Res 58:1216-21. 2005
    Studies in premature animals suggest that 1) prolonged tight constriction of the ductus arteriosus is necessary for permanent anatomic closure and 2) endogenous nitric oxide (NO) and prostaglandins both play a role in ductus patency...
  85. ncbi In utero indomethacin alters O2 delivery to the fetal ductus arteriosus: implications for postnatal patency
    Seth H Goldbarg
    Cardiovascular Research Institute, University of California, San Francisco, California 94143 0544, USA
    Am J Physiol Regul Integr Comp Physiol 282:R184-90. 2002
    Indomethacin produces constriction and hypoxia of the fetal ductus arteriosus. This is associated with death of smooth muscle cells in the ductus wall and an increased incidence of patent ductus arteriosus in the newborn period...
  86. ncbi [The pharmacological manipulation of Botallo's duct in the duct-dependent congenital cardiopathies and in the preterm infants with respiratory distress. A review and personal findings]
    G Distefano
    Dipartimento di Pediatria, Universita degli Studi di Catania, Policlinico, Catania
    Minerva Pediatr 57:21-34. 2005
    ....
  87. ncbi Factors associated with permanent closure of the ductus arteriosus: a role for prolonged indomethacin therapy
    Dolores Quinn
    Cardiovascular Research Institute, Department of Pediatrics, University of California, San Francisco, California 94143 0544, USA
    Pediatrics 110:e10. 2002
    The most important factor determining anatomic remodeling and permanent closure of the ductus arteriosus is the degree of ductus constriction after indomethacin treatment...
  88. ncbi Reference values for ductus venosus Doppler flow measurements at 10-14 weeks of gestation
    F Prefumo
    U O di Ostetricia e Ginecologia, Istituto G Gaslini, University of Genova, Italy
    Ultrasound Obstet Gynecol 20:42-6. 2002
    ..To calculate reference ranges for ductus venosus Doppler measurements obtained transabdominally at 10-14 weeks of gestation...
  89. ncbi The effects of caffeine on the preterm sheep ductus arteriosus
    Ronald I Clyman
    Cardiovascular Research Institute and Department of Pediatrics, University of California San Francisco, San Francisco, California 94143, USA
    Pediatr Res 62:167-9. 2007
    ..randomly assigned to caffeine treatment had less need for pharmacologic and/or surgical closure of a patent ductus arteriosus (PDA)...
  90. ncbi [Prenatal tolerability evaluation of diclofenac]
    Piotr Przybylski
    Akademia Medyczna w Lublinie, Pracownia Teratologii Doświadczalnej Katedry i Zakładu Anatomii Prawidłowej Człowieka
    Pol Merkur Lekarski 22:229-32. 2007
    ..However, intrauterine growth retardation, constriction of ductus arteriosus, fetal anuria, oligohydramnions and other prostanoid-related side-effects were already reported...
  91. ncbi Effects of hypoxia, hypoglycemia, and muscle shortening on cell death in the sheep ductus arteriosus
    Seth Goldbarg
    Box 0544, HSE 1492, University of California San Francisco, 513 Parnassus Ave, San Francisco, CA 94143 0544, U S A
    Pediatr Res 54:204-11. 2003
    After birth, constriction of the full-term ductus arteriosus produces ischemic hypoxia, caspase activation, DNA fragmentation (>70% of cell nuclei are positive by the terminal deoxynucleotidyl transferase nick-end labeling [TUNEL] ..
  92. ncbi Betamethasone attenuates oxidant stress in endothelial cells from fetal lambs with persistent pulmonary hypertension
    Indira Chandrasekar
    Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin 53201, USA
    Pediatr Res 63:67-72. 2008
    ..Betamethasone reversed the increased superoxide/decreased cGMP levels and restored Hsp90-eNOS interactions in PPHN. Betamethasone reduces oxidative stress and improves response of pulmonary arteries to vasodilators in lambs with PPHN...
  93. ncbi Opposite effects of redox status on membrane potential, cytosolic calcium, and tone in pulmonary arteries and ductus arteriosus
    Andrea Olschewski
    Justus Leipzig University, Giessen, Germany
    Am J Physiol Lung Cell Mol Physiol 286:L15-22. 2004
    At birth, associated with the rise in oxygen tension, the pulmonary arteries (PA) dilate and the ductus arteriosus (DA) constricts. Both PA and DA constrict with vasoconstrictors and dilate with vasodilators...
  94. ncbi A double-blind randomized study of fetal side effects during and after the short-term maternal administration of indomethacin, sulindac, and nimesulide for the treatment of preterm labor
    Robert J Sawdy
    Imperial College School of Medicine, Institute of Reproductive and Developmental Biology, Queen Charlotte s Hospital, London, United Kingdom
    Am J Obstet Gynecol 188:1046-51. 2003
    ..The purpose of this study was to establish whether nimesulide causes fewer fetal side effects than indomethacin or sulindac after short-term maternal exposure for tocolysis...
  95. ncbi Prenatal demonstration of major aortopulmonary collateral arteries with tetralogy of Fallot and pulmonary atresia
    Susumu Miyashita
    Department of Perinatology, National Cardiovascular Center, Osaka, Japan
    Fetal Diagn Ther 19:100-5. 2004
    ..Fetal echocardiography was essential for the diagnosis of TOF-PA, but further examination was needed to find collateral arteries, which provided useful information for management after birth...
  96. ncbi Live three-dimensional echocardiography of the human fetus
    Dev Maulik
    Department of Obstetrics and Gynecology, Winthrop University Hospital, Mineola, New York 11501, USA
    Echocardiography 20:715-21. 2003
    ..This preliminary investigation suggests that live three-dimensional fetal echocardiography could be a significant tool for prenatal diagnosis and assessment of congenital heart disease in the human fetus...
  97. doi The effect of ductal diameter on surgical and medical closure of patent ductus arteriosus in preterm neonates: size matters
    Scott Tschuppert
    Division of Congenital Cardiovascular Surgery, University Children s Hospital, University of Zurich, Zurich, Switzerland
    J Thorac Cardiovasc Surg 135:78-82. 2008
    We sought to analyze the effect of patent ductus arteriosus diameter on treatment success in premature neonates.
  98. ncbi Ductus venosus blood flow velocity characteristics of fetuses with single umbilical artery
    L Raio
    Department of Obstetrics and Gynecology, University of Berne, Switzerland
    Ultrasound Obstet Gynecol 22:252-6. 2003
    ..The aim of this study was to investigate the ductus venosus blood flow profile in fetuses with single umbilical artery and to correlate it with the umbilical cord morphology...
  99. ncbi Echo-Doppler ultrasonographic assessment of resistance and velocity of blood flow in the ductus venosus throughout gestation in fetal lambs
    M Panarace
    GOYAIKE S A A C I y F Biotechnology Area, Ea San Joaquín CC, Carmen de Areco CP, Buenos Aires, Argentina
    Theriogenology 70:648-54. 2008
    ..4+/-8.8cm/s to 104.9+/-19.7 and aV from 24.8+/-6.9 to 54.9+/-5.9; P<0.05). In conclusion, Doppler ultrasonography facilitated assessment of the blood flow pattern in the ductus venosus in lamb fetuses between Days 52 and 143...
  100. ncbi The safety of prolonged indomethacin therapy
    Ashlyn H Savage
    Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Am J Perinatol 24:207-13. 2007
    ..women treated with indomethacin was used to assess the outcomes of oligohydramnios, constriction of the ductus arteriosus, and composite neonatal morbidity. Eight patients (6.5%) developed ductal constriction and nine patients (7...
  101. ncbi Increased nuchal translucency and pathological ductus venosus flow: two cases of TRAP sequence with different outcomes
    H Meyberg
    Praxis für pränatale Dianostik und feto maternale Medizin, Ludwigsburg, Germany
    Ultrasound Obstet Gynecol 20:72-4. 2002
    ..In these cases the increased nuchal translucency thickness and the pathological ductus venosus flow pattern may have been prognostic of the pregnancy outcome...

Research Grants71

  1. REGULATION OF PULMONARY CIRCULATION IN FETUS AND NEWBORN
    Girija G Konduri; Fiscal Year: 2010
    ..Studies will be done in PAEC and pulmonary arteries harvested from lambs with prenatal ligation of ductus arteriosus (PPHN) and in sham ligation controls...
  2. GI-Safer Formulation of Indomethacin for use in Preterm Neonates
    UPENDRA K MARATHI; Fiscal Year: 2010
    ..feeding and the use of indomethacin, the standard of care to treat and/or prevent the development of Patent Ductus Arteriosus (PDA)...
  3. RANDOMIZED INDOMETHACIN GMH/IVH PREVENTION TRIAL
    Laura Ment; Fiscal Year: 1991
    ..low grade GMH/IVH at 6 postnatal hours, 2) investigation of the ability of indomethacin to close the patent ductus arteriosus in very low birth weight neonates, 3) investigation of the ability of indomethacin to promote significant ..
  4. RANDOMIZED INDOMETHACIN GMH/IVH PREVENTION TRIAL
    Laura Ment; Fiscal Year: 1993
    ..low grade GMH/IVH at 6 postnatal hours, 2) investigation of the ability of indomethacin to close the patent ductus arteriosus in very low birth weight neonates, 3) investigation of the ability of indomethacin to promote significant ..
  5. O2 sensing in the human and rabbit ductus arteriosus
    Stephen L Archer; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): The ductus arteriosus (DA) is a fetal artery that allows blood ejected from the right ventricle to bypass the pulmonary circulation in utero...
  6. O2 sensing in the human and rabbit ductus arteriosus
    Stephen Archer; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): The ductus arteriosus (DA) is a fetal artery that allows blood ejected from the right ventricle to bypass the pulmonary circulation in utero...
  7. RANDOMIZED INDOMETHACIN GMH/IVH PREVENTION TRIAL
    Laura Ment; Fiscal Year: 1990
    ..low grade GMH/IVH at 6 postnatal hours, 2) investigation of the ability of indomethacin to close the patent ductus arteriosus in very low birth weight neonates, 3) investigation of the ability of indomethacin to promote significant ..
  8. RANDOMIZED INDOMETHACIN GMH/IVH PREVENTION TRIAL
    Laura Ment; Fiscal Year: 1992
    ..low grade GMH/IVH at 6 postnatal hours, 2) investigation of the ability of indomethacin to close the patent ductus arteriosus in very low birth weight neonates, 3) investigation of the ability of indomethacin to promote significant ..
  9. Antenatal betamethasone for persistent pulmonary hypertension of newborn
    Girija G Konduri; Fiscal Year: 2010
    ..Studies will be done in lambs with prenatal ligation of ductus arteriosus to induce PPHN. Pregnant ewes will be randomly assigned to receive betamethasone or saline...
  10. Antenatal betamethasone for persistent pulmonary hypertension of newborn
    GIRIJA KONDURI; Fiscal Year: 2009
    ..Studies will be done in lambs with prenatal ligation of ductus arteriosus to induce PPHN. Pregnant ewes will be randomly assigned to receive betamethasone or saline...
  11. Neurodevelopmental Outcomes in Infants with HLHS after Hybrid Stage I Palliation
    Sharon L Hill; Fiscal Year: 2010
    ..After the Hybrid procedure, cerebral perfusion is dependent upon the blood flow through the stented patent ductus arteriosus and retrograde aortic arch flow to the carotid arteries, similar to fetal life, for approximately 6 months ..
  12. Neurodevelopmental Outcomes in Infants with HLHS after Hybrid Stage I Palliation
    Sharon Hill; Fiscal Year: 2009
    ..After the Hybrid procedure, cerebral perfusion is dependent upon the blood flow through the stented patent ductus arteriosus and retrograde aortic arch flow to the carotid arteries, similar to fetal life, for approximately 6 months ..
  13. Closure of the Primate Ductus Arteriosus
    Ronald Clyman; Fiscal Year: 2005
    In the premature infant, the ductus arteriosus frequently remains open for many days after birth. As many as 70% of newborns delivered prior to 28 weeks gestation will require some form of therapy to close their patent ductus...
  14. Closure of the Primate Ductus Arteriosus
    Ronald Clyman; Fiscal Year: 2004
    In the premature infant, the ductus arteriosus frequently remains open for many days after birth. As many as 70% of newborns delivered prior to 28 weeks gestation will require some form of therapy to close their patent ductus...
  15. Closure of the Primate Ductus Arteriosus
    Ronald Clyman; Fiscal Year: 2003
    In the premature infant, the ductus arteriosus frequently remains open for many days after birth. As many as 70% of newborns delivered prior to 28 weeks gestation will require some form of therapy to close their patent ductus...
  16. CARDIOVASCULAR RESPONSES TO STRESS DURING DEVELOPMENT
    ABRAHAM RUDOLPH; Fiscal Year: 1980
    ..the effects of hypoxia and other acute and chronic stress; 12) The role of prostaglandins in regulation of ductus arteriosus responses before and after birth and the effects of acute and chronic stress on prostaglandin metabolism and ..
  17. Advanced Source Reconstruction Techniques for Fetal Magnetocardiography
    Mihai Popescu; Fiscal Year: 2009
    ..g. intra-uterine growth retardation, diabetes, pulmonary valve and aortic stenosis, closure of the ductus arteriosus, tetralogy of Fallot, or ventricular septal defect...
  18. LUNG MICROCIRCULATION IN THE NEWBORN
    Usha Raj; Fiscal Year: 1993
    ..2. In the immature lung following surfactant therapy, development of increased blood flow through a patent ductus arteriosus results in very high capillary pressures, stress failure of capillaries and pulmonary hemorrhage. 3...
  19. ETIOLOGY AND DEVELOPMENT OF CONGENITAL HEART DISEASES
    Donald Patterson; Fiscal Year: 1999
    ..underlying two hereditary forms of congenital heart disease: Conotruncal defects (CTDs) and patent ductus arteriosus (PDA)...
  20. ETIOLOGY AND DEVELOPMENT OF CONGENITAL HEART DISEASE
    Donald Patterson; Fiscal Year: 1990
    ..underlying two hereditary forms of congenital heart disease: Conotruncal defects (CTDs) and patent ductus arteriosus (PDA)...
  21. REPRODUCTION AND SURVIVAL AFTER CARDIAC DEFECT REPAIR
    Cynthia Morris; Fiscal Year: 1993
    ..of the aorta, pulmonic stenosis (PS), aortic stenosis (AS), transposition of the great arteries, patent ductus arteriosus (PDA), tricuspid atresia (TA), total anomalous pulmonary venous return (TAPVR), pulmonary atresia with ..
  22. REPRODUCTION AND SURVIVAL AFTER CARDIAC DEFECT REPAIR
    Cynthia Morris; Fiscal Year: 1990
    ..TOF), coarctation of the aorta, aortic stenosis (AS), transposition of the great arteries (TGA), and patent ductus arteriosus (PDA)...
  23. EICOSANOID SYNTHESIS
    John Falck; Fiscal Year: 1991
    ..The EETS have been confirmed as endogenous constituents of mammalian production, ductus arteriosus contraction and transformations of eicosanoids produced by other branches of arachidonate cascade...
  24. EICOSANOID SYNTHESIS
    John Falck; Fiscal Year: 1990
    ..The EETS have been confirmed as endogenous constituents of mammalian production, ductus arteriosus contraction and transformations of eicosanoids produced by other branches of arachidonate cascade...
  25. FAMILIAL PATENT DUCTUS ARTERIOSUS
    Bruce Gelb; Fiscal Year: 2002
    ..Verbatim from Applicant's Abstract): Char syndrome is an inherited heart-hand disorder comprising patent ductus arteriosus (PDA), abnormal 5th fingers, and facial dysmorphism...
  26. FAMILIAL PATENT DUCTUS ARTERIOSUS
    Bruce Gelb; Fiscal Year: 2002
    ..Verbatim from Applicant's Abstract): Char syndrome is an inherited heart-hand disorder comprising patent ductus arteriosus (PDA), abnormal 5th fingers, and facial dysmorphism...
  27. FAMILIAL PATENT DUCTUS ARTERIOSUS
    Bruce Gelb; Fiscal Year: 2002
    ..Verbatim from Applicant's Abstract): Char syndrome is an inherited heart-hand disorder comprising patent ductus arteriosus (PDA), abnormal 5th fingers, and facial dysmorphism...
  28. FAMILIAL PATENT DUCTUS ARTERIOSUS
    Bruce Gelb; Fiscal Year: 2003
    ..Verbatim from Applicant's Abstract): Char syndrome is an inherited heart-hand disorder comprising patent ductus arteriosus (PDA), abnormal 5th fingers, and facial dysmorphism...
  29. FAMILIAL PATENT DUCTUS ARTERIOSUS
    Bruce Gelb; Fiscal Year: 2004
    ..Verbatim from Applicant's Abstract): Char syndrome is an inherited heart-hand disorder comprising patent ductus arteriosus (PDA), abnormal 5th fingers, and facial dysmorphism...
  30. FAMILIAL PATENT DUCTUS ARTERIOSUS
    Bruce Gelb; Fiscal Year: 2001
    ..Verbatim from Applicant's Abstract): Char syndrome is an inherited heart-hand disorder comprising patent ductus arteriosus (PDA), abnormal 5th fingers, and facial dysmorphism...
  31. FAMILIAL PATENT DUCTUS ARTERIOSUS
    Bruce Gelb; Fiscal Year: 2000
    ..Verbatim from Applicant's Abstract): Char syndrome is an inherited heart-hand disorder comprising patent ductus arteriosus (PDA), abnormal 5th fingers, and facial dysmorphism...
  32. REGULATION OF THE DUCTUS ARTERIOSUS
    Ronald Clyman; Fiscal Year: 2000
    ..These studies should increase our understanding of what initiates and sustains the process of ductus closure after birth and why it does not occur in the preterm infant. ..
  33. REGULATION OF THE DUCTUS ARTERIOSUS
    Ronald Clyman; Fiscal Year: 2002
    ..These studies should increase our understanding of what initiates and sustains the process of ductus closure after birth and why it does not occur in the preterm infant. ..
  34. REGULATION OF THE DUCTUS ARTERIOSUS
    Ronald Clyman; Fiscal Year: 2001
    ..These studies should increase our understanding of what initiates and sustains the process of ductus closure after birth and why it does not occur in the preterm infant. ..
  35. REGULATION OF THE DUCTUS ARTERIOSUS
    Ronald Clyman; Fiscal Year: 1999
    ..These studies should increase our understanding of what initiates and sustains the process of ductus closure after birth and why it does not occur in the preterm infant. ..
  36. VESSEL REMODELING DURING FETAL DUCTUS ARTERIOSUS CLOSURE
    Ronald Clyman; Fiscal Year: 2001
    In the full term neonate, the ductus arteriosus constricts rapidly after delivery in order to separate the pulmonary from the systemic circulations...
  37. O2 Sensing in the Ductus Arteriosus
    Stephen Archer; Fiscal Year: 2004
    The ductus arteriosus (DA) is a fetal artery that allows blood ejected from the right ventricle to bypass the pulmonary circulation in utero...
  38. O2 Sensing in the Ductus Arteriosus
    Stephen Archer; Fiscal Year: 2005
    The ductus arteriosus (DA) is a fetal artery that allows blood ejected from the right ventricle to bypass the pulmonary circulation in utero...
  39. O2 Sensing in the Ductus Arteriosus
    Stephen Archer; Fiscal Year: 2007
    The ductus arteriosus (DA) is a fetal artery that allows blood ejected from the right ventricle to bypass the pulmonary circulation in utero...
  40. O2 Sensing in the Ductus Arteriosus
    Stephen Archer; Fiscal Year: 2006
    The ductus arteriosus (DA) is a fetal artery that allows blood ejected from the right ventricle to bypass the pulmonary circulation in utero...
  41. O2 Sensing in the Ductus Arteriosus
    Stephen Archer; Fiscal Year: 2007
    The ductus arteriosus (DA) is a fetal artery that allows blood ejected from the right ventricle to bypass the pulmonary circulation in utero...
  42. Disease pathogenesis/Noonan syndrome/related disorders
    Bruce Gelb; Fiscal Year: 2004
    ..Char syndrome, which has a phenotype that includes patent ductus arteriosus, is caused by transcription factor AP-2beta dominant-negative mutations...
  43. Disease pathogenesis of Noonan syndrome and related disorders
    Bruce Gelb; Fiscal Year: 2007
    ..Char syndrome, which has a phenotype that includes patent ductus arteriosus, is caused by transcription factor AP-2beta dominant-negative mutations...
  44. SELF-REGULATORY NEWBORN CARE AND EXTRAUTERINE ADAPTATION
    Gene Anderson; Fiscal Year: 1991
    ..of venous blood through the foramen ovale (OF), relative systemic hypoxemia, and delayed closure of the ductus arteriosus (DA)...
  45. Disease pathogenesis/Noonan syndrome/related disorders
    Bruce Gelb; Fiscal Year: 2006
    ..Char syndrome, which has a phenotype that includes patent ductus arteriosus, is caused by transcription factor AP-2beta dominant-negative mutations...
  46. Disease pathogenesis/Noonan syndrome/related disorders
    Bruce Gelb; Fiscal Year: 2005
    ..Char syndrome, which has a phenotype that includes patent ductus arteriosus, is caused by transcription factor AP-2beta dominant-negative mutations...
  47. SELF-REGULATORY NEWBORN CARE AND EXTRAUTERINE ADAPTATION
    Gene Anderson; Fiscal Year: 1993
    ..of venous blood through the foramen ovale (OF), relative systemic hypoxemia, and delayed closure of the ductus arteriosus (DA)...
  48. TRANSLUMINAL ANGIOPLASTY-CONVENITAL HEART DISEASE
    James Anderson; Fiscal Year: 1990
    ..In addition, stents will be evaluated as a means of maintaining patency of the ductus arteriosus. In the last project, the application of fixed diameter angioplasty balloon dilataion procedures for atrial ..
  49. MANAGEMENT OF PATENT DUCTUS IN PREMATURE INFANTS
    ALEXANDER NADAS; Fiscal Year: 1980
    In the small preterm infants, patent ductus arteriosus (PDA) is a common and often serious concomitant of respiratory distress syndrome (RDS)...
  50. REGULATION OF THE PERINATAL PULMONARY CIRCULATION
    SIDNEY CASSIN; Fiscal Year: 1980
    ..harmful side effects on the fetus and newborn of pharmacological agents such as indomethacin, aspirin and meclofenamate which are currently used clinically to prevent premature delivery as well as to close patent ductus arteriosus.
  51. ROLE OF ENDOTHELIN IN PERINATAL PULMONARY VASOREGULATION
    DAVID IVY; Fiscal Year: 1999
    ..ET-1) in the normal fetal lung and in a model of pulmonary hypertension caused by in utero ligation of the ductus arteriosus. He has extensive experience in whole animal physiology, but only beginning training in molecular biology...
  52. ROLE OF ENDOTHELIN IN PERINATAL PULMONARY VASOREGULATION
    DAVID IVY; Fiscal Year: 2000
    ..ET-1) in the normal fetal lung and in a model of pulmonary hypertension caused by in utero ligation of the ductus arteriosus. He has extensive experience in whole animal physiology, but only beginning training in molecular biology...
  53. ROLE OF ENDOTHELIN IN PERINATAL PULMONARY VASOREGULATION
    DAVID IVY; Fiscal Year: 2001
    ..ET-1) in the normal fetal lung and in a model of pulmonary hypertension caused by in utero ligation of the ductus arteriosus. He has extensive experience in whole animal physiology, but only beginning training in molecular biology...
  54. ROLE OF ENDOTHELIN IN PERINATAL PULMONARY VASOREGULATION
    DAVID IVY; Fiscal Year: 2002
    ..ET-1) in the normal fetal lung and in a model of pulmonary hypertension caused by in utero ligation of the ductus arteriosus. He has extensive experience in whole animal physiology, but only beginning training in molecular biology...
  55. VESSEL REMODELING DURING FETAL DUCTUS ARTERIOSUS CLOSURE
    Ronald Clyman; Fiscal Year: 1992
    In the full term neonate, the ductus arteriosus constricts rapidly after delivery in order to separate the pulmonary from the systemic circulations...
  56. REGULATION OF PULMONARY CIRCULATION IN FETUS AND NEWBORN
    GIRIJA KONDURI; Fiscal Year: 2003
    ..The hypotheses will be investigated in fetal lambs with pulmonary hypertension induced by constriction of ductus arteriosus, an established model of PPHN, and in control lambs with sham ligation of ductus arteriosus...
  57. REGULATION OF PULMONARY CIRCULATION IN FETUS AND NEWBORN
    GIRIJA KONDURI; Fiscal Year: 2006
    ..The hypotheses will be investigated in fetal lambs with pulmonary hypertension induced by constriction of ductus arteriosus, an established model of PPHN, and in control lambs with sham ligation of ductus arteriosus...
  58. INHALED NITRIC OXIDE IN THE NEONATE
    Beverly Banks; Fiscal Year: 2000
    ..requiring high frequency ventilation, presumed sepsis with hypotension requiring dopamine, and a patent ductus arteriosus. Echocardiogram on arrival at CHOP showed pulmonary hypertension with right to left shunting through the ..
  59. REGULATION OF PULMONARY CIRCULATION IN FETUS AND NEWBORN
    GIRIJA KONDURI; Fiscal Year: 2005
    ..The hypotheses will be investigated in fetal lambs with pulmonary hypertension induced by constriction of ductus arteriosus, an established model of PPHN, and in control lambs with sham ligation of ductus arteriosus...
  60. REGULATION OF PULMONARY CIRCULATION IN FETUS AND NEWBORN
    GIRIJA KONDURI; Fiscal Year: 2004
    ..The hypotheses will be investigated in fetal lambs with pulmonary hypertension induced by constriction of ductus arteriosus, an established model of PPHN, and in control lambs with sham ligation of ductus arteriosus...
  61. TGFb and Cardiac Neural Crest Cell Fate and Function
    Henry Sucov; Fiscal Year: 2006
    ..aortic arch (IAA- B); later in gestation, the elastic matrix of the neural crest-derived vessel wall of the ductus arteriosus becomes disorganized, leading to vessel wall dilation (aneurysm)...
  62. TGFb and Cardiac Neural Crest Cell Fate and Function
    Henry Sucov; Fiscal Year: 2009
    ..aortic arch (IAA- B);later in gestation, the elastic matrix of the neural crest-derived vessel wall of the ductus arteriosus becomes disorganized, leading to vessel wall dilation (aneurysm)...
  63. TGFb and Cardiac Neural Crest Cell Fate and Function
    Henry Sucov; Fiscal Year: 2007
    ..aortic arch (IAA- B); later in gestation, the elastic matrix of the neural crest-derived vessel wall of the ductus arteriosus becomes disorganized, leading to vessel wall dilation (aneurysm)...
  64. AORTIC ARCH SELECTION IN THE CHICK EMBRYO
    David Connuck; Fiscal Year: 1990
    ..regression of these arches results in cardiovascular malformations such as interrupted aortic arch, patent ductus arteriosus and pulmonary atresia...