fetal heart

Summary

Summary: The heart of the fetus of any viviparous animal. It refers to the heart in the postembryonic period and is differentiated from the embryonic heart (HEART/embryology) only on the basis of time.

Top Publications

  1. ncbi Pulmonary artery/aorta ratio in simple screening for fetal outflow tract abnormalities during the second trimester
    S F Wong
    Department of Maternal Fetal Medicine, Mater Mothers Hospital, South Brisbane, QLD, Australia
    Ultrasound Obstet Gynecol 30:275-80. 2007
  2. ncbi Delayed structural development in an acardiac fetus: an echographic observation
    C Van Gaever
    Department of Obstetrics and Gynaecology, Ghent University Hospital, Ghent, Belgium
    Fetal Diagn Ther 23:100-4. 2008
  3. ncbi Fetal cardiac output, distribution to the placenta and impact of placental compromise
    T Kiserud
    Department of Clinical Medicine, Section of Obstetrics and Gynaecology, University of Bergen, Bergen, Norway
    Ultrasound Obstet Gynecol 28:126-36. 2006
  4. pmc Intracardiac septation requires hedgehog-dependent cellular contributions from outside the heart
    Matthew M Goddeeris
    Department of Cell Biology, Duke University Medical Center, Durham, NC, USA
    Development 135:1887-95. 2008
  5. ncbi Expression of type VI collagen in the developing mouse heart
    S E Klewer
    Department of Pediatrics, University of Arizona College of Medicine, Tucson, USA
    Dev Dyn 211:248-55. 1998
  6. ncbi Evaluation of fetal heart dimensions from 12 weeks to term
    C Firpo
    University of California-San Francisco 94143, USA
    Am J Cardiol 87:594-600. 2001
  7. ncbi A protective antiarrhythmic role of ursodeoxycholic acid in an in vitro rat model of the cholestatic fetal heart
    Michele Miragoli
    National Heart and Lung Institute, Imperial College London, London, England
    Hepatology 54:1282-92. 2011
  8. ncbi Four chamber view plus three-vessel and trachea view for a complete evaluation of the fetal heart during the second trimester
    Antongiulio Del Bianco
    Dipartimento Materno Infantile, Unità Operativa di Ostetricia e Ginecologia 2, Policlinico Univesitario, Foggia, Italy
    J Perinat Med 34:309-12. 2006
  9. ncbi Collaborative study on 4-dimensional echocardiography for the diagnosis of fetal heart defects: the COFEHD study
    Jimmy Espinoza
    Division of Fetal Imaging, Department of Obstetrics and Gynecology, William Beaumont Hospital, 3601 W Thirteen Mile Road, Royal Oak, MI 48073 USA
    J Ultrasound Med 29:1573-80. 2010
  10. ncbi Heart stroke volume, cardiac output, and ejection fraction in 265 normal fetus in the second half of gestation assessed by 4D ultrasound using spatio-temporal image correlation
    Christiane Simioni
    Department of Obstetrics, Sao Paulo Federal University UNIFESP, Sao Paulo, Brazil
    J Matern Fetal Neonatal Med 24:1159-67. 2011

Detail Information

Publications214 found, 100 shown here

  1. ncbi Pulmonary artery/aorta ratio in simple screening for fetal outflow tract abnormalities during the second trimester
    S F Wong
    Department of Maternal Fetal Medicine, Mater Mothers Hospital, South Brisbane, QLD, Australia
    Ultrasound Obstet Gynecol 30:275-80. 2007
    ..This ratio was investigated as a simple screening tool for congenital cardiac outflow tract abnormalities...
  2. ncbi Delayed structural development in an acardiac fetus: an echographic observation
    C Van Gaever
    Department of Obstetrics and Gynaecology, Ghent University Hospital, Ghent, Belgium
    Fetal Diagn Ther 23:100-4. 2008
    ..Only few serial ultrasound observations are reported, showing the delayed development in the recipient twin...
  3. ncbi Fetal cardiac output, distribution to the placenta and impact of placental compromise
    T Kiserud
    Department of Clinical Medicine, Section of Obstetrics and Gynaecology, University of Bergen, Bergen, Norway
    Ultrasound Obstet Gynecol 28:126-36. 2006
    ..Our aim was to determine the normal distribution of fetal cardiac output to the placenta during the second half of pregnancy, and to assess the changes imposed by growth restriction with various degrees of placental compromise...
  4. pmc Intracardiac septation requires hedgehog-dependent cellular contributions from outside the heart
    Matthew M Goddeeris
    Department of Cell Biology, Duke University Medical Center, Durham, NC, USA
    Development 135:1887-95. 2008
    ..Failure of this addition results in severe AVSD. These studies demonstrate that AVSD can result from a primary defect in dorsal mesocardium, providing a new paradigm for the understanding of human AVSD...
  5. ncbi Expression of type VI collagen in the developing mouse heart
    S E Klewer
    Department of Pediatrics, University of Arizona College of Medicine, Tucson, USA
    Dev Dyn 211:248-55. 1998
    ....
  6. ncbi Evaluation of fetal heart dimensions from 12 weeks to term
    C Firpo
    University of California-San Francisco 94143, USA
    Am J Cardiol 87:594-600. 2001
    ..The frequency of obtaining data in younger normal fetuses suggests it is unlikely that reliable observations can be made routinely in abnormal fetuses < 16 weeks old, although this might be possible in individual fetuses...
  7. ncbi A protective antiarrhythmic role of ursodeoxycholic acid in an in vitro rat model of the cholestatic fetal heart
    Michele Miragoli
    National Heart and Lung Institute, Imperial College London, London, England
    Hepatology 54:1282-92. 2011
    ..However, their presence in the fetal heart (FH) and their proarrhythmogenic effects have not been systematically characterized...
  8. ncbi Four chamber view plus three-vessel and trachea view for a complete evaluation of the fetal heart during the second trimester
    Antongiulio Del Bianco
    Dipartimento Materno Infantile, Unità Operativa di Ostetricia e Ginecologia 2, Policlinico Univesitario, Foggia, Italy
    J Perinat Med 34:309-12. 2006
    ..To test the efficacy of a recently introduced ultrasonic scanning plane (three vessel and trachea view -3VTV- plus color flow mapping -3VTVC) on a low-risk population for detection of congenital heart disease (CHD)...
  9. ncbi Collaborative study on 4-dimensional echocardiography for the diagnosis of fetal heart defects: the COFEHD study
    Jimmy Espinoza
    Division of Fetal Imaging, Department of Obstetrics and Gynecology, William Beaumont Hospital, 3601 W Thirteen Mile Road, Royal Oak, MI 48073 USA
    J Ultrasound Med 29:1573-80. 2010
    ..Accumulating evidence indicates that 4DUS with STIC may facilitate the examination of the fetal heart. Our objectives were to determine the accuracy of 4DUS for the diagnosis of CHDs and the agreement among centers...
  10. ncbi Heart stroke volume, cardiac output, and ejection fraction in 265 normal fetus in the second half of gestation assessed by 4D ultrasound using spatio-temporal image correlation
    Christiane Simioni
    Department of Obstetrics, Sao Paulo Federal University UNIFESP, Sao Paulo, Brazil
    J Matern Fetal Neonatal Med 24:1159-67. 2011
    ..The aim of this study was to establish nomograms for fetal stroke volume (SV), cardiac output (CO), and ejection fraction (EF) using four-dimensional ultrasound with spatio-temporal image correlation (STIC) modality...
  11. ncbi Serotonin and its transporter on proliferation of fetal heart cells
    Youssef Sari
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, MS508, Indianapolis, IN 46202, USA
    Int J Dev Neurosci 21:417-24. 2003
    ..In this study, we report that in addition to trophic effect, 5-HT increases the proliferation of fetal heart cells...
  12. ncbi Identification of the t-type calcium channel (Ca(v)3.1d) in developing mouse heart
    L L Cribbs
    Cardiovascular Institute, Loyola University Medical Center, Maywood, Ill, USA
    Circ Res 88:403-7. 2001
    ..We demonstrate that 100 micromol/L Ni(2+) partially blocked alpha1G currents under physiological external Ca(2+). We conclude that alpha1G T-type Ca(2+) channels are functional in midgestational fetal myocardium...
  13. ncbi Feasibility of MRI of the fetal heart with balanced steady-state free precession sequence along fetal body and cardiac planes
    Sahar N Saleem
    Department of Radiology, Cairo University, Kasr Al Ainy Hospital, 4 49th St, Cairo 11571, Egypt
    AJR Am J Roentgenol 191:1208-15. 2008
    The purpose of this study was to evaluate the feasibility of imaging the fetal heart with a balanced steady-state free precession MRI sequence along the body and cardiac axes after inadequate echocardiography.
  14. pmc Hypoxia and fetal heart development
    A J Patterson
    Center for Perinatal Biology, Department of Physiology and Pharmacology, Loma Linda University School of Medicine, Loma Linda, CA 92350, USA
    Curr Mol Med 10:653-66. 2010
    ..factor 1 (HIF-1) and vascular endothelial growth factor play central roles in hypoxia-dependent signaling in fetal heart formation, impacting embryonic outflow track remodeling and coronary vessel growth...
  15. ncbi 3D and 4D ultrasound in fetal cardiac scanning: a new look at the fetal heart
    S Yagel
    Department of Obstetrics and Gynecology, Hadassah Hebrew University Medical Centers, Jerusalem, Israel
    Ultrasound Obstet Gynecol 29:81-95. 2007
    ..Recent advances in the technology of 3D/4D ultrasound systems allow almost real-time 3D/4D fetal heart scans...
  16. pmc Response of the fetal heart to changes in load: from hyperplasia to heart failure
    H M Gardiner
    Institute of Reproductive and Developmental Biology, Faculty of Medicine, Imperial College, Queen Charlotte s and Chelsea Hospital, Du Cane Road, London, W12 ONN, UK
    Heart 91:871-3. 2005
  17. ncbi Mending a growth-restricted fetal heart: should we use glucocorticoids?
    Ryan J Hodges
    Maternal Fetal Medicine, Monash Medical Centre, Southern Health, Victoria, Australia
    J Matern Fetal Neonatal Med 25:2149-53. 2012
    ..Indeed is it possible that in the setting of severe IUGR exogenous glucocorticoids are detrimental rather than beneficial to the fetus?..
  18. ncbi Fetal heart scanning in the first trimester
    Julene S Carvalho
    Brompton Fetal Cardiology, Royal Brompton Hospital and Fetal Medicine Unit, St George s Hospital, London, UK
    Prenat Diagn 24:1060-7. 2004
    ..Therefore, fetal heart scanning in the first trimester should be performed in conjunction with detailed first-trimester obstetric ..
  19. ncbi Reference intervals for fetal heart volume from 3-dimensional sonography using the extended imaging virtual organ computer-aided analysis method at gestational ages of 20 to 34 weeks
    Enoch Quinderé de Sá Barreto
    Department of Obstetrics, Federal University of Sao Paulo, Sao Paulo SP, Brazil
    J Ultrasound Med 31:673-8. 2012
    The purpose of this study was to establish the reference range for fetal heart volume from 3-dimensional (3D) sonography using the extended imaging virtual organ computer-aided analysis method.
  20. ncbi Sequential changes of longitudinal and radial myocardial deformation indices in the healthy neonate heart
    José Luiz Barros Pena
    Heart Institute InCor USP, Sao Paulo, Brazil
    J Am Soc Echocardiogr 23:294-300. 2010
    ..This study was designed to determine if these indices can detect variations in regional deformation between early and late neonatal periods...
  21. ncbi Examination of the fetal heart by four-dimensional ultrasound with spatiotemporal image correlation during routine second-trimester examination: the 'three-steps technique'
    Giuseppe Rizzo
    Department of Obstetrics and Gynecology, Universita di Roma Tor Vergata, Rome, Italy
    Fetal Diagn Ther 24:126-31. 2008
    ....
  22. ncbi Third trimester fetal heart rate and Doppler middle cerebral artery blood flow velocity characteristics during prenatal selective serotonin reuptake inhibitor exposure
    Dan Rurak
    Department of Obstetrics and Gynecology, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada
    Pediatr Res 70:96-101. 2011
    ..Maternal mood and cord Hb and hematocrit were measured. Basal fetal heart rate (fHR) did not differ between groups or across the day...
  23. ncbi Beta1-adrenergic receptors maintain fetal heart rate and survival
    Rashmi Chandra
    Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA
    Biol Neonate 89:147-58. 2006
    ..It also investigates which betaARs are located on the early fetal heart and whether they can be directly activated during hypoxia. Cultured E12...
  24. ncbi Changes in cardiac troponins with gestational age explain changes in cardiac muscle contractility in the sheep fetus
    Giuseppe Saverio Posterino
    Department of Zoology, School of Life Sciences, Faculty of Science and Technology, LaTrobe University, Melbourne, Vic, Australia
    J Appl Physiol (1985) 111:236-43. 2011
    ..Furthermore, changes in cardiac troponin C, not I, protein expression track with the timing of cardiomyocyte binucleation...
  25. ncbi Strain rate derived from color Doppler myocardial imaging for assessment of fetal cardiac function
    L U Larsen
    Department of Obstetrics and Gynecology, Aarhus University Hospital, Aarhus, Denmark
    Ultrasound Obstet Gynecol 27:210-3. 2006
    ..The purpose of this study was to assess the feasibility of CDMI in the fetal heart.
  26. ncbi [Effect of hyperglycaemia on fetal heart in pregnant rats]
    Yan Zou
    Department of Obstetrics and Gynaecology, Central South University, Changsha 410011, China
    Zhong Nan Da Xue Xue Bao Yi Xue Ban 34:139-47. 2009
    ..To investigate the effect of hyperglycaemia on the cardiomyodial change of rat fetus...
  27. ncbi High resolution MR imaging of the fetal heart with cardiac triggering: a feasibility study in the sheep fetus
    Jin Yamamura
    Department of Diagnostic and Interventional Radiology, University Hospital Hamburg Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany
    Eur Radiol 19:2383-90. 2009
    The aim of this study was to perform fetal cardiac magnetic resonance imaging (MRI) with triggering of the fetal heart beat in utero in a sheep model...
  28. ncbi Fetal loss in threatened abortion after embryonic/fetal heart activity
    Y Tannirandorn
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
    Int J Gynaecol Obstet 81:263-6. 2003
    To study the incidence of fetal loss in threatened abortion after detection of embryonic/fetal heart activity.
  29. ncbi Fetal heart ventricular mass obtained by STIC acquisition combined with inversion mode and VOCAL
    B Messing
    Department of Obstetrics and Gynecology, Hadassah Hebrew University Medical Centers, Jerusalem, Israel
    Ultrasound Obstet Gynecol 38:191-7. 2011
    Estimation of fetal heart ventricular mass is important for fetal cardiac evaluation in cases of structural or functional cardiac disorders or extracardiac factors...
  30. ncbi [Tissue Doppler imaging of the fetal heart--a new parametric ultrasound technique in prenatal medicine]
    J Steinhard
    Fetal Cardiac Imaging Research Group Münster, Westfalische Wilhelms Universitat Munster
    Ultraschall Med 28:578-83. 2007
    ..Tissue Doppler imaging is the first step in parametric imaging of the fetal heart and consequently marks the beginning of a new era in fetal echocardiography.
  31. ncbi Doppler echocardiographic studies of diastolic cardiac function in the human fetal heart
    T Miyake
    Department of Pediatrics and Child Health, Kurume University School of Medicine, 67 Asahi-machi, Kurume 830-0011, Japan
    Kurume Med J 48:59-64. 2001
    ..Fetuses with IUGR and of DM may have abnormal diastolic cardiac function in later gestation...
  32. ncbi Myocardial tissue Doppler and long axis function in the fetal heart
    Helena M Gardiner
    Royal Brompton Hospital, UK
    Int J Cardiol 113:39-47. 2006
    ..Current echocardiographic assessment of fetal ventricular function uses relatively crude measures and this has led to inconsistencies in assessment of diastolic function. Long axis parameters may be more insightful...
  33. ncbi Fetal tissue Doppler echocardiography: detection rates of cardiac structures and quantitative assessment of the fetal heart
    B Tutschek
    Gynaecology and Obstetrics, University Hospital Dusseldorf, Dusseldorf Germany
    Ultrasound Obstet Gynecol 21:26-32. 2003
    ..Doppler echocardiography (TDE) has been developed in adult cardiology, but only recently has it been applied to fetal heart studies...
  34. ncbi Toward quantitative fetal heart rate monitoring
    Hanqing Cao
    Department of Biomedical Engineering, University of Virginia, Charlottesville 22908, USA
    IEEE Trans Biomed Eng 53:111-8. 2006
    Continuous electronic fetal heart rate (FHR) monitoring during labor is motivated by the clinical experience that fetal distress causes loss of FHR variation and the occurrence of decelerations late during uterine contraction...
  35. ncbi Right ventricular myocardium derives from the anterior heart field
    Stephane Zaffran
    Department of Developmental Biology, CNRS URA 2578, Pasteur Institute, 25 rue du Dr Roux, Paris, 75015, France
    Circ Res 95:261-8. 2004
    ..This study demonstrates the differences in the embryological origin of right and left ventricular myocardium, which has important implications for congenital heart disease...
  36. pmc Concepts of cardiac development in retrospect
    Gert van den Berg
    Heart Failure Research Center, Academic Medical Center, Amsterdam, The Netherlands
    Pediatr Cardiol 30:580-7. 2009
    ..In this communication we present excerpts of important embryological studies of the pioneers of experimental cardiac embryology of the previous century, to relate insights from the past to current observations...
  37. ncbi The information content of Doppler ultrasound signals from the fetal heart
    S A Shakespeare
    School of Electrical and Electronic Engineering, University of Nottingham, UK
    Med Biol Eng Comput 39:619-26. 2001
    Knowledge of the content of Doppler ultrasound signals from the fetal heart is essential if the performance of fetal heart rate (FHR) monitors based upon this technology is to be improved...
  38. ncbi The fetal heart rate response to hypoxia: insights from animal models
    Laura Bennet
    Department of Physiology, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland, New Zealand
    Clin Perinatol 36:655-72. 2009
    This article examines recent studies that have systematically dissected features of fetal heart rate responses to labor that may help identify developing fetal compromise, such as the slope of the deceleration, overshoot, and variability...
  39. pmc Overnutrition and maternal obesity in sheep pregnancy alter the JNK-IRS-1 signaling cascades and cardiac function in the fetal heart
    Jingying Wang
    Department of Pharmacology and Toxicology, School of Medicine and Biomedical Sciences, University at Buffalo SUNY, Buffalo, NY 14214, USA
    FASEB J 24:2066-76. 2010
    ..05) in OB fetal heart associated with lower downstream PI3K-Akt activity (P<0.05), indicating impaired cardiac insulin signaling...
  40. ncbi Monitoring the fetal heart non-invasively: a review of methods
    M Peters
    Graduate School iBME, Faculty of Applied Physics, University of Twente, Enschede, The Netherlands
    J Perinat Med 29:408-16. 2001
    ..ultrasound M-mode analysis, fetal electrocardiography, and fetal magnetocardiography are methods by which the fetal heart can be monitored non-invasively. In this paper, they are evaluated and compared...
  41. ncbi Self-gating MR imaging of the fetal heart: comparison with real cardiac triggering
    Jin Yamamura
    Department of Diagnostic and Interventional Radiology, University Medical Center Hamburg Eppendorf, Martinistrase 52, 20246, Hamburg, Germany
    Eur Radiol 21:142-9. 2011
    To investigate the self-gating technique for MR imaging of the fetal heart in a sheep model.
  42. ncbi Prospective, randomized trial comparing general with spinal anesthesia for cesarean delivery in preeclamptic patients with a nonreassuring fetal heart trace
    Robert A Dyer
    Department of Anesthesia, University of Cape Town and New Groote Schuur Hospital, Cape Town, South Africa
    Anesthesiology 99:561-9; discussion 5A-6A. 2003
    ..studies on neonatal outcome after spinal versus general anesthesia for cesarean delivery in preeclamptic patients with a nonreassuring fetal heart trace. This study examined both markers of neonatal hypoxia and maternal hemodynamics.
  43. ncbi Reconstruction of the patterns of gene expression in the developing mouse heart reveals an architectural arrangement that facilitates the understanding of atrial malformations and arrhythmias
    Alexandre T Soufan
    Experimental and Molecular Cardiology Group, Academic Medical Centre, University of Amsterdam, The Netherlands
    Circ Res 95:1207-15. 2004
    ..All these regions are derived from primary myocardium, providing a molecular basis for the observed nonrandom distribution of focal right atrial tachycardias...
  44. ncbi Collagen type VI expression during cardiac development and in human fetuses with trisomy 21
    Adriana C Gittenberger-de Groot
    Department of Anatomy and Embryology, Leiden University Medical Center, Leiden, The Netherlands
    Anat Rec A Discov Mol Cell Evol Biol 275:1109-16. 2003
    ..We hypothesise that collagen VI has a role in the development of heart defects involving endocardial cushion differentiation-specifically in the AV canal, the most common site of malformations affecting children with trisomy 21...
  45. pmc Maternal diabetes and the fetal heart
    L K Hornberger
    Heart 92:1019-21. 2006
    Maternal diabetes mellitus significantly affects the fetal heart and fetal-placental circulation in both structure and function...
  46. ncbi Spatio-temporal image correlation (STIC): new technology for evaluation of the fetal heart
    G R DeVore
    Fetal Diagnostic Center of Pasadena, Pasadena, CA 91105, USA
    Ultrasound Obstet Gynecol 22:380-7. 2003
    Spatio-temporal image correlation (STIC) is a new approach for clinical assessment of the fetal heart. It offers an easy to use technique to acquire data from the fetal heart and to aid in visualization with both two-dimensional and ..
  47. ncbi Cardiac screening by STIC: can sonologists performing the 20-week anomaly scan pick up outflow tract abnormalities by scrolling the A-plane of STIC volumes?
    D Paladini
    Department of Gynecology and Obstetrics, University Federico II of Naples, Naples, Italy
    Ultrasound Obstet Gynecol 32:865-70. 2008
    ....
  48. ncbi Transplacental fetal treatment improves the outcome of prenatally diagnosed complete atrioventricular block without structural heart disease
    Edgar T Jaeggi
    Division of Cardiology, Department of Pediatrics, The Hospital for Sick Children, Toronto, Ontario, Canada
    Circulation 110:1542-8. 2004
    ..A standardized treatment approach, including maternal dexamethasone at CAVB diagnosis and beta-stimulation for fetal heart rates <55 bpm, has been used at our institutions since 1997. The study presents the impact of this approach.
  49. pmc Four-dimensional ultrasonography of the fetal heart using a novel Tomographic Ultrasound Imaging display
    Luis F Goncalves
    Perinatology Research Branch, National Institute of Child Health and Human Development, NIH DHHS, Bethesda, MD, USA
    J Perinat Med 34:39-55. 2006
    The objective of this study was to investigate the feasibility of examining the fetal heart with Tomographic Ultrasound Imaging (TUI) using four-dimensional (4D) volume datasets acquired with spatiotemporal image correlation (STIC).
  50. ncbi American Society of Echocardiography guidelines and standards for performance of the fetal echocardiogram
    Jack Rychik
    The Children s Hospital of Philadelphia, Philadelphia, PA, USA
    J Am Soc Echocardiogr 17:803-10. 2004
  51. ncbi Effects of long-term, high-altitude hypoxia on the capillarity of the ovine fetal heart
    A M Lewis
    Center for Perinatal Biology, Loma Linda University, Loma Linda 92350, California, USA
    Am J Physiol 277:H756-62. 1999
    ..Contrary to our hypothesis, the ovine fetus does not show morphological adaptation in the myocardium after approximately 109 days of high-altitude hypoxic stress...
  52. ncbi Comparison of entropy-based regularity estimators: application to the fetal heart rate signal for the identification of fetal distress
    Manuela Ferrario
    Dipartimento di Bioingegneria, University Politecnico di Milano, Italy
    IEEE Trans Biomed Eng 53:119-25. 2006
    ..We applied the approximate entropy and the sample entropy estimators to fetal heart rate signals on both single and multiple scales for an early identification of fetal sufferance antepartum...
  53. pmc The effects of anaemia as a programming agent in the fetal heart
    L Davis
    Department of Obstetrics and Gynecology, Oregon Health Sciences University, Portland, OR 97201 3098, USA
    J Physiol 565:35-41. 2005
    ..New information on these mechanisms is likely to lead to better prevention of and therapies for adult-onset coronary disease...
  54. ncbi Lung and heart volumes by three-dimensional ultrasound in normal fetuses at 12-32 weeks' gestation
    C F A Peralta
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital Medical School, London, UK
    Ultrasound Obstet Gynecol 27:128-33. 2006
    ..To establish reference intervals for the fetal right, left and total lung volumes and heart volume between 12 and 32 weeks of gestation...
  55. ncbi Application of three-dimensional ultrasonography in the evaluation of the fetal heart
    G Bega
    Department of Radiology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    J Ultrasound Med 20:307-13; quiz 315-6. 2001
    ..16 to 26 weeks' gestation, were scanned with two-dimensional ultrasonography for 10 minutes or less to obtain fetal heart views...
  56. ncbi Maternal position during non-stress test and fetal heart rate patterns
    Giuseppe Cito
    Obstetrics and Gynecology, Department of Pediatrics, Obstetrics and Reproductive Medicine, University of Siena, Siena, Italy
    Acta Obstet Gynecol Scand 84:335-8. 2005
    The aim of the study was to determinate whether maternal position during the non-stress test (NST) in different weeks of pregnancy influences fetal heart rate patterns.
  57. ncbi Convergent proliferative response and divergent morphogenic pathways induced by epicardial and endocardial signaling in fetal heart development
    Ji One Kang
    Institute for Genetic Medicine, Keck School of Medicine, University of Southern California, IGM240, 2250 Alcazar St, Los Angeles, CA 90033, USA
    Mech Dev 122:57-65. 2005
    ..We therefore conclude that epicardial and endocardial signals converge on common proliferative components, but diverge in downstream pathways that lead to compact vs. trabecular morphogenic differentiation...
  58. ncbi Standardization of on-screen fetal heart orientation prior to storage of spatio-temporal image correlation (STIC) volume datasets
    D Paladini
    Ultrasound Obstet Gynecol 29:605-11. 2007
  59. ncbi Maternal diabetes causes coordinated down-regulation of genes involved with lipid metabolism in the murine fetal heart
    Marie L S Lindegaard
    Department of Clinical Biochemistry, Rigshospitalet, 2100 Copenhagen, Denmark
    Metabolism 57:766-73. 2008
    ..On embryonic days 16 to 19, the fetal heart weight and triglyceride content were similar in offspring from Ins2(Akita) and nondiabetic wild-type mothers...
  60. ncbi Automated sonography: defining the spatial relationship of standard diagnostic fetal cardiac planes in the second trimester of pregnancy
    Alfred Abuhamad
    Department of Obstetrics and Gynecology, Eastern Virginia Medical School, Hofheimer Hall, Suite 310, 825 Fairfax Ave, Norfolk, VA 23507, USA
    J Ultrasound Med 26:501-7. 2007
    This study defines the spatial relationship of the diagnostic planes of the fetal heart to the 4-chamber view plane in the second trimester of pregnancy as a first step in the automation process.
  61. pmc Intracardiac pressures in the human fetus
    P Johnson
    Imperial College School of Medicine, Queen Charlotte s and Chelsea Hospital, Goldhawk Road, London W4 0XG, UK
    Heart 84:59-63. 2000
    ..To obtain normal values for intracardiac pressures in the human fetus...
  62. ncbi Single pass sequencing of a unidirectional human fetal heart cDNA library to discover novel genes of the cardiovascular system
    D M Hwang
    Laboratory for Molecular Cardiology, University of Toronto, Ontario, Canada
    J Mol Cell Cardiol 26:1329-33. 1994
    A human fetal heart cDNA library was constructed in the lambda gt22A expression vector. Polymerase chain reaction (PCR) was used to amplify the cDNA inserts...
  63. ncbi A systematic analysis of the feasibility of four-dimensional ultrasound imaging using spatiotemporal image correlation in routine fetal echocardiography
    L B Uittenbogaard
    Department of Obstetrics and Gynecology, VU University Medical Center, Amsterdam, The Netherlands
    Ultrasound Obstet Gynecol 31:625-32. 2008
    ..To investigate the feasibility of incorporating spatiotemporal image correlation (STIC) into a tertiary fetal echocardiography program...
  64. ncbi Four-dimensional ultrasonography of the fetal heart with spatiotemporal image correlation
    Luis F Goncalves
    Perinatology Research Branch, National Institute of Child Health and Human Development, National Institutes of Health Department of Health and Human Services, Bethesda, MD, USA
    Am J Obstet Gynecol 189:1792-802. 2003
    This study was undertaken to describe a new technique for the examination of the fetal heart using four-dimensional ultrasonography with spatiotemporal image correlation (STIC).
  65. pmc A spatiotemporal evaluation of the contribution of the dorsal mesenchymal protrusion to cardiac development
    Brian S Snarr
    Department of Cell Biology and Anatomy, Cardiovascular Developmental Biology Center, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Dev Dyn 236:1287-94. 2007
    ..This new model for atrioventricular septation may provide novel insights into understanding the etiology of congenital cardiac malformations...
  66. ncbi Sequential segmental analysis in complex fetal cardiac abnormalities: a logical approach to diagnosis
    J S Carvalho
    Ultrasound Obstet Gynecol 26:105-11. 2005
  67. ncbi Application of automated sonography on 4-dimensional volumes of fetuses with transposition of the great arteries
    Giuseppe Rizzo
    Department of Obstetrics and Gynecology, Universita di Roma Tor Vergata, Ospedale Fatebenefratelli S Giovanni Calabita, Isola Tiberina 89, 00186 Rome, Italy
    J Ultrasound Med 27:771-6; quiz 777. 2008
    ....
  68. ncbi Outcome of antenatally diagnosed cardiac rhabdomyoma: case series and a meta-analysis
    A S Chao
    Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital and Chang Gung University, Tao Yuan, Taiwan
    Ultrasound Obstet Gynecol 31:289-95. 2008
    ..Rhabdomyoma, the most common primary fetal cardiac tumor, is often associated with tuberous sclerosis (TS). We aimed to evaluate outcome in cases diagnosed with fetal cardiac rhabdomyoma...
  69. ncbi Prenatal course of isolated muscular ventricular septal defects diagnosed only by color Doppler sonography: single-institution experience
    Mert Ozan Bahtiyar
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520 8063, USA
    J Ultrasound Med 27:715-20. 2008
    ..The prevalence of these lesions is not yet completely described, and the frequency with which muscular VSDs resolve in utero has also not been extensively reported...
  70. ncbi Risk factors for cardiac malformations detected by fetal echocardiography in a tertiary center
    Tamar Perri
    Perinatal Division, Department of Obstetrics and Gynecology, Rabin Medical Center, Beilinson Campus, Petah Tiqva, Israel
    J Matern Fetal Neonatal Med 17:123-8. 2005
    ..Fetal echocardiography accurately detects congenital cardiac anomalies, but it is costly, time-consuming, and requires highly-skilled operators. Our aim was to define those patients for whom fetal echocardiography is justified...
  71. ncbi Incremental diagnostic yield of pediatric cardiac assessment after fetal echocardiography in the offspring of women with congenital heart disease: a prospective study
    Molly Thangaroopan
    University of Toronto Pregnancy and Heart Disease Research Program, Mount Sinai Hospital, Toronto, Ontario, Canada
    Pediatrics 121:e660-5. 2008
    ..We sought to determine the incremental diagnostic utility of pediatric cardiac assessment in the offspring of women with congenital heart disease who have had previous fetal echocardiography...
  72. ncbi [Assessment of fetal circulation in the late first trimester--preliminary study]
    Piotr Kaczmarek
    Klinika Perinatologii i Ginekologii Instytutu Centrum Zdrowia Matki Polki 93 338 Lódi
    Ginekol Pol 78:861-4. 2007
    ..to confirm that fetal echocardiography is indeed possible in late first trimester and that it improves the standard of the so-called "genetic" ultrasound scan...
  73. ncbi Increasing cardiac output and decreasing oxygenation sequence in pump twins of acardiac twin pregnancies
    Martin J C van Gemert
    Laser Center and Department of Obstetrics and Gynecology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
    Phys Med Biol 50:N33-42. 2005
    ....
  74. ncbi Diagnosis of cardiac anomalies in offspring of women with congenital heart disease: is fetal echocardiography enough?
    Lindsey D Allan
    Harris Birthright Fetal Medicine Unit, King s College Hospital, London, UK
    Nat Clin Pract Cardiovasc Med 5:522-3. 2008
    ..Most of these minor defects will be diagnosed by routine clinical cardiac examination and can be confirmed by pediatric echocardiography...
  75. ncbi Clinical implications of the prenatal sonographic finding of fetal myocardial echogenic foci
    Ivana M Vettraino
    Department of Obstetrics and Gynecology, Division of Fetal Imaging, William Beaumont Hospital, 3601 W Thirteen Mile Rd, Royal Oak, MI 48073 6769, USA
    J Ultrasound Med 24:195-9. 2005
    ..The purpose of this study was to investigate the clinical implications of fetal echogenic foci limited to the myocardium of the ventricular wall (EMF) or intraventricular septum detected during prenatal sonography...
  76. ncbi Outcome of fetuses and infants with double inlet single left ventricle
    Edythe B C Tham
    Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts, USA
    Am J Cardiol 101:1652-6. 2008
    ..During this same period, postnatal survival has improved substantially. Neonatal surgery of any type was the only independent risk factor for worse survival...
  77. ncbi Isomerism of the left atrial appendage associated with ventricular noncompaction
    Mark K Friedberg
    Pediatric Echocardiography, Division of Pediatric Cardiology, Department of Pediatrics, Lucille Packard Children s Hospital and Stanford University, Stanford, California, USA
    Am J Cardiol 96:985-90. 2005
    ..Prenatal recognition is possible by ultrasound, facilitating appropriate prenatal counseling...
  78. ncbi Fetal cardiac contractility before and after intrauterine transfusion
    E Sikkel
    Department of Obstetrics, Leiden University Medical Center, Leiden, The Netherlands
    Ultrasound Obstet Gynecol 26:611-7. 2005
    ..To evaluate the effect of fetal anemia and intrauterine transfusion on ventricular shortening fraction...
  79. doi ACOG Practice Bulletin, clinical management guidelines for obstetrician-gynecologists number 98, October 2008 (replaces Practice Bulletin number 58, December 2004). Ultrasonography in pregnancy
    Alfred Z Abuhamad
    Obstet Gynecol 112:951-61. 2008
  80. ncbi [Assessment of myocardial performance in fetuses by using Tei index]
    Qian Chen
    Department of Obstetrics and Gynecology, Peking University, First Hospital, Beijing 100034, China
    Zhonghua Fu Chan Ke Za Zhi 41:387-90. 2006
    ..To define the value of Tei index of normal fetuses and to estimate the influence of gestational week and heart rate on the index...
  81. ncbi Ductus venosus blood flow alterations in fetuses with obstructive lesions of the right heart
    C Berg
    Department of Obstetrics and Prenatal Medicine, University of Bonn, Germany
    Ultrasound Obstet Gynecol 28:137-42. 2006
    ..To assess the impact of isolated lesions of the fetal right heart on ductus venosus (DV) blood flow profiles...
  82. ncbi [Prenatal diagnosis of congenital fetal heart abnormalities in twins by Yagel's heart examination method]
    Hui Li
    Department of Obstetrics and Gynecology, Affiliated Shengjing Hospital, China Medical University, Shenyang 110004, China
    Zhonghua Fu Chan Ke Za Zhi 42:83-6. 2007
    ..To investigate the value and clinical significance of congenital heart diseases (CHD) detection in twins...
  83. ncbi Z-scores of the fetal aortic isthmus and duct: an aid to assessing arch hypoplasia
    L Pasquini
    Institute of Reproductive and Developmental Biology, Faculty of Medicine, Imperial College, Queen Charlotte s and Chelsea Hospital, London, UK
    Ultrasound Obstet Gynecol 29:628-33. 2007
    ..The aim of our study was to develop Z-scores for the aortic isthmus in normal fetuses as a reference for fetuses with suspected coarctation...
  84. ncbi Clinical implication of isolated right dominant heart in the fetus
    Eui Jung
    Department of Obstetrics and Gynecology, College of Medicine, Kyunghee University, Seoul, Korea
    Prenat Diagn 27:695-8. 2007
    ..To evaluate the clinical implication of isolated right dominant heart (RDH) in fetal echocardiography...
  85. ncbi Fetal cardiac intervention: innovative therapy or a technique in search of an indication?
    Charles S Kleinman
    Circulation 113:1378-81. 2006
  86. ncbi Huge pericardial rhabdomyoma with hypoplastic left ventricle and lung
    Makoto Takeuchi
    Department of Pathology, Osaka Medical Center and Research Institute for Maternal and Child Health, Osaka, Japan
    Am J Perinatol 23:89-92. 2006
    ..Microscopically, the cardiac tumor showed characteristics of rhabdomyoma. This localization of cardiac rhabdomyoma is rare, but we remain aware of the possibility of an unusual and rapid progression of cardiac rhabdomyoma...
  87. ncbi Spectrum of cardiovascular disease, accuracy of diagnosis, and outcome in fetal heterotaxy syndrome
    Mio Taketazu
    Department of Pediatric Cardiology, Saitama Medical School, Moroyama, Japan
    Am J Cardiol 97:720-4. 2006
    ..Fetal LAI is associated with a mortality of 31%, with heart block and extracardiac pathology as primary risk factors for perinatal mortality. The outcome of prenatally diagnosed RAI is poor...
  88. ncbi Fetal cardiac ventricle volumetry in the second half of gestation assessed by 4D ultrasound using STIC combined with inversion mode
    B Messing
    Department of Obstetrics and Gynecology, Hadassah Hebrew University Medical Centers, Mt Scopus, Jerusalem, Israel
    Ultrasound Obstet Gynecol 30:142-51. 2007
    Quantification of fetal heart ventricle volume can aid in the evaluation of functional and anatomical aspects of congenital heart disease...
  89. ncbi Diagnosis of absent ductus venosus in a population referred for fetal echocardiography: association with a persistent portosystemic shunt requiring postnatal device occlusion
    Ruben J Acherman
    Fetal Cardiology Program, Children s Heart Center, Las Vegas, NV 89109, USA
    J Ultrasound Med 26:1077-82. 2007
    ..The purpose of this series was to assess the incidence, anatomic variants, and implications of an absent ductus venosus (ADV) in patients referred for fetal echocardiography...
  90. ncbi Ductus venosus blood flow resistance and congenital heart defects in the second trimester
    Jeng Hsiu Hung
    Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei, Taiwan
    J Clin Ultrasound 36:72-8. 2008
    ..To study the association between fetal cardiac defects and the presence of abnormal blood flow resistance of the ductus venosus during the second trimester of pregnancy...
  91. ncbi Effect of pregestational diabetes mellitus on fetal cardiac function and structure
    Noirin E Russell
    Department of Obstetrics and Gynaecology, National Maternity Hospital, Dublin, Ireland
    Am J Obstet Gynecol 199:312.e1-7. 2008
    ..The aim of this study was to assess the interrelation between cardiac functional and structural changes in fetuses of mothers with pregestational diabetes mellitus...
  92. ncbi [Prenatal diagnosis of congenital heart disease by echocardiography in Matanzas Province, Cuba, from 1990 to 1995]
    Antonio E González Font
    Cardiólogo Pediatra, Hospital Municipal del Niño, Durango, Dgo, Clínica de Especialidades AMCCI
    Arch Cardiol Mex 75:159-64. 2005
    ....
  93. ncbi Caliber of the coronary sinus in fetuses with cardiac defects with and without left persistent superior vena cava and in growth-restricted fetuses with heart-sparing effect
    R Chaoui
    Department of Obstetrics and Gynecology, Charité Medical School CCM, Humboldt University, Schumannstrasse 20 21, D 10098 Berlin, Germany
    Prenat Diagn 23:552-7. 2003
    ....
  94. ncbi How successful is fetal echocardiographic examination in the first trimester of pregnancy?
    M C Haak
    Department of Obstetrics and Gynecology, Vrije Univesiteit Medical Center, Amsterdam, The Netherlands
    Ultrasound Obstet Gynecol 20:9-13. 2002
    ..This study was undertaken to explore the possibilities of fetal echocardiography in the late first trimester...
  95. ncbi Early prenatal diagnosis of major cardiac anomalies in a high-risk population
    C Comas Gabriel
    Fetal Medicine Unit, Department of Obstetrics and Gynaecology, Institut Universitari Dexeus, Barcelona, Spain
    Prenat Diagn 22:586-93. 2002
    ..To examine the accuracy of early fetal echocardiography performed in a high-risk population combining transvaginal and transabdominal routes...
  96. ncbi Reference values of fetal ductus venosus, inferior vena cava and hepatic vein blood flow velocities and waveform indices during the second and third trimester of pregnancy
    R Axt-Fliedner
    Division of Prenatal Medicine, Department of Obstetrics and Gynecology, University of Schleswig Holstein Campus Lubeck, Germany
    Arch Gynecol Obstet 270:46-55. 2004
    ....
  97. ncbi Three-dimensional (3D) and 4D color Doppler fetal echocardiography using spatio-temporal image correlation (STIC)
    R Chaoui
    Unit of Prenatal Diagnosis and Therapy, Charite University Hospital, Berlin, Germany
    Ultrasound Obstet Gynecol 23:535-45. 2004
    ..STIC) is a new three-dimensional (3D) technique allowing the acquisition of a volume of data from the fetal heart that is displayed as a cineloop of a single cardiac cycle...
  98. ncbi Validation of the Doppler PR interval in the fetus
    David Rosenthal
    Diagnostic Services Laboratory, Room 1751, Stanford University, Palo Alto, CA 94304, USA
    J Am Soc Echocardiogr 15:1029-30. 2002
  99. ncbi Latest advances and topics in fetal echocardiography
    Aarti Hejmadi Bhat
    Clinical Care Center for Congenital Heart Disease, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
    Curr Opin Cardiol 19:97-103. 2004
    ..The authors review some of the major advancements in thought and practice in the field of fetal echocardiography while attempting to give a less detailed overview for the less involved perinatologist...
  100. ncbi Screening fetal echocardiography by telemedicine: efficacy and community acceptance
    Sangeeta Sharma
    Department of Pediatrics, Mount Sinai Medical Center, New York, NY 10029, USA
    J Am Soc Echocardiogr 16:202-8. 2003
    ..Our aim was to assess whether tertiary level screening fetal echocardiography can be extended to primary care facilities with telemedicine assistance...
  101. ncbi Prenatal echocardiographic differential diagnosis of fetal cardiac tumors
    Q C Zhou
    Department of Ultrasonography, Department of Obstetrics and Gynecology, Second Xiangya Hospital, Central South University, Changsha, P R China
    Ultrasound Obstet Gynecol 23:165-71. 2004
    ..To present data on echocardiographic findings of fetal cardiac tumors and discuss their differential diagnoses...

Research Grants64

  1. The unique role of B-Raf in murine cardiac development and postnatal function
    Natasha N Chattergoon; Fiscal Year: 2013
    ..I joined this laboratory to train in fetal heart development and how changes to the fetal environment dramatically alter heart growth...
  2. Hypoplastic Left Heart Syndrome: Expression of RHD in the Fetus?
    Pirooz Eghtesady; Fiscal Year: 2013
    ..produced in response to antecedent (and recurrent) strep infection, cross the placenta and damage the fetal heart in the susceptible host...
  3. Perinatal Assessment of At-Risk Populations
    William P Fifer; Fiscal Year: 2013
    ..abdominal fECG device we will investigate maternal/fetal ECG interactions, the effect of uterine activity on fetal heart rate, incidence and variation in fetal arrhythmias, fetal movement and heart rate coupling, patterns of heart ..
  4. The Effect of Maternal Stress on Perinatal Development
    LISA J ECKLUND-FLORES; Fiscal Year: 2011
    ..Previous studies have shown that maternal anxiety and depression influence fetal heart rate reactivity...
  5. Intrauterine hypoxia induces cytokine gene expression in fetal cardiac ventricles
    LASHAUNA C EVANS; Fiscal Year: 2010
    ..a link between hypoxia-induced upregulation of the iNOS pathway and proinflammatory cytokine expression in the fetal heart. The first aim will demonstrate the effects of chronic hypoxia exposure resulting in sustained gene expression ..
  6. Pre-Clinical Development of a Fetal Micropacemaker
    Ramen Chmait; Fiscal Year: 2013
    ..treatment options in these cases, and attempts to implant an extra-uterine pacemaker with electrodes on the fetal heart have invariably failed due to lead dislodgement from fetal movement...
  7. The Effects of Docosahexaenoic acid (DHA) on fetal cardiac outcomes
    Kathleen M Gustafson; Fiscal Year: 2010
    ..In this small sample, we found lower fetal heart rate and higher fetal heart rate variability...
  8. Identification of a Stretch-Activated Channel with a Role in Cardiac Development
    Dipayan Chaudhuri; Fiscal Year: 2013
    ..in cardiomyocyte proliferation may prove critical to field of regenerative medicine, as the maturation of the fetal heart is known to depend on the forces created by a heartbeat...
  9. Gender preference and maternal stress in China
    Kek Khee Loo; Fiscal Year: 2010
    ..b>Fetal heart rate and movement data will be measured using fetal actocardiography at T2 and T3...
  10. Impact of Antenatal Depression, Anxiety, and Stress on Fetal
    Zachary N Stowe; Fiscal Year: 2011
    ..While such studies have demonstrated alterations in fetal activity, fetal heart rate, and an increase in obstetrical complications (low birth weight, preterm labor, preterm delivery), they ..
  11. Photonic Magnetometer-based Biomagnetic Imaging System
    John Matthews; Fiscal Year: 2010
    ..as arrhythmia-causing regions, a pacing catheter and cardiac evoked field, or ischemic currents, and (d) study fetal heart function...
  12. Characterization of the GET Pathway and its Potential Role in Heart Development
    Brittney A Manvilla; Fiscal Year: 2013
    ..CHD5, which function was previously unknown, is abundantly expressed in human fetal heart, kidney, lungs, and liver and has been linked to the progression of congenital heart disease in Down Syndrome ..
  13. Iroquois Homeobox Transcription Factors in Heart Development and Physiology
    BENOIT GAETAN BRUNEAU; Fiscal Year: 2010
    ..properties to specialized cardiac lineages, and thereby are involved in establishing important aspects of late fetal heart development and postnatal physiology...
  14. Transvaginal probe for fetal magnetocardiography
    DOUGLAS N PAULSON; Fiscal Year: 2012
    ..This presents a series problem in the assessment of fetal heart conditions in patients with high- risk cardiac conditions in specific, and in prenatal care management in ..
  15. Noninvasive Optoacoustic Monitoring of Intrapartum Fetal Cerebral Hypoxia
    GRAHAM RANDALL; Fiscal Year: 2013
    ..Although fetal heart rate monitoring provides an indirect indicator of fetal oxygenation, to date, there are no commercially ..
  16. Developing an animal model of HLHS: role of immune mediated injury
    Pirooz Eghtesady; Fiscal Year: 2012
    ..produced in response to antecedent (and recurrent) strep infection, cross the placenta and damage the fetal heart in the susceptible host...
  17. Myocardial Protection during Fetal Bypass: Role of Calcium Cycling
    Charles R Cole; Fiscal Year: 2011
    ..Our long-term goal is to successfully translate fetal heart surgery into the clinical setting...
  18. Generation of human myocardium from native ECM scaffolds and adult derived cells
    Harald C Ott; Fiscal Year: 2012
    ..These ECM scaffolds supported engraftment of fetal heart cells to form contractile tissue...
  19. PREDICTING FETAL ACIDEMIA WITH INTRAPARTUM ELECTRONIC FETAL HEART RATE MONITORING
    George A Macones; Fiscal Year: 2013
    DESCRIPTION (provided by investigator): Intrapartum electronic fetal heart rate monitoring (EFM) has become the most frequently used instrument in obstetrics in the United States, despite its classification as a "D" by the U.S...
  20. The Safe Fetus Project
    ADAM JOHN WOLFBERG; Fiscal Year: 2012
    ..research is to identify physiologic characteristics - including specific fetal ECG waveforms and patterns of fetal heart-rate variability - that predict infection-related neurologic injury during pregnancy and labor...
  21. Conformal, Portable External Fetal Heart Monitor
    Martin Culjat; Fiscal Year: 2011
    External fetal heart monitors (FHM) allow for intermittent or continuous monitoring of fetal status both before and during labor, and reduce medical costs by allowing fewer nurses or midwives to manage a larger number patients...
  22. OPTIMIZED MEASUREMENT AND SIGNAL PROCESSING OF FETAL MCG
    Ronald T Wakai; Fiscal Year: 2013
    ..of fetal magnetocardiography (fMCG), the magnetic analog of fetal ECG, as an effective new method of assessing fetal heart rate, rhythm, and conduction...
  23. Electrohysterogram-based sensor for non-invasive contraction monitoring with impr
    Neil R Euliano; Fiscal Year: 2011
    ..In addition, the 510(k) submission will be prepared. Aim 4: Initial testing of an acoustic sensor for fetal heart rate monitoring - The next generation product will include a more reliable replacement for the ultrasound FHR ..
  24. ONTOGENY AND HORMONAL CONTROL OF CARDIAC NADH SHUTTLES
    Thomas Scholz; Fiscal Year: 2001
    ..will then be used to determine the effect of insulin and altered thyroid function on shuttle capacity in the fetal heart. Twin fetal sheet will receive saline infusion (control twin) or infusion of either insulin or triiodothyronine ..
  25. Notch function in myocardial development and homeostasis
    Mark Mercola; Fiscal Year: 2010
    ..of action, timing, and Notch isoform requirements for proliferation, lineage selection and morphogenesis of fetal heart development...
  26. Mechanism of Vasopressin-Mediated Placental Vascular Resistance after Fetal Bypas
    Pirooz Eghtesady; Fiscal Year: 2010
    ..complex lesions begin early in fetal life as simple defects that cause abnormal blood flow patterns within the fetal heart, but ultimately result in abnormal development of major cardiac structures...
  27. Fetal Magnetocardiography Using Non-cryogenic Magnetic Field Sensors
    VISHAL K SHAH; Fiscal Year: 2012
    ..a new magnetic sensor technology for fetal magnetocardiography, a highly promising method of assessing serious fetal heart rate and rhythm disorders...
  28. Spiral Electrode Sensor for Intrapartum Fetal Oximetry
    JONAS POLOGE; Fiscal Year: 2003
    b>Fetal heart rate monitoring is intended to detect signs of fetal distress due to oxygen starvation of the fetus...
  29. Advanced Source Reconstruction Techniques for Fetal Magnetocardiography
    Mihai Popescu; Fiscal Year: 2009
    ..sustained efforts to improve the existing tools and methodologies used for the non-invasive screening of the fetal heart structure and physiology...
  30. YAP1 Regulation of cardiomyocyte proliferation, function, and regeneration
    WILLIAM TSWENCHING PU; Fiscal Year: 2013
    ..hypothesis that YAP1 mediates nuclear signaling by plakoglobin-containing cell adhesion junctions to regulate fetal heart growth and adult heart function...
  31. Spiral Electrode Sensor for Intrapartum Fetal Oximetry
    JONAS POLOGE; Fiscal Year: 2006
    ..b>Fetal heart rate monitoring is intended to detect signs of fetal distress due to oxygen starvation of the fetus...
  32. DEVELOPMENTAL CHANGES IN HEART AND MUSCLE PFK ISOZYMES
    George Dunaway; Fiscal Year: 1991
    ..and examination of the properties and subunit composition of the PFK isozymes in the following tissues: (1) fetal heart and muscle during the week prior to partition, (2) different types of muscle fibers during the first month of ..
  33. Role of Ca channels in congenital heart block
    Mohamed Boutjdir; Fiscal Year: 2007
    ..have reproduced the clinical complete AV block in an animal model of CHB and in isolated Langendorff perfused fetal heart. These findings were correlated with maternal anti-Ro/La antibodies' inhibition of L-type (1c Ca channel...
  34. Fetal Coronary Vascular Responses to Long-term Hypoxia
    RAYMOND GILBERT; Fiscal Year: 2005
    Maintenance of an adequate coronary blood flow is critical to fetal heart development, as well as to normal development of the fetus itself...
  35. Is thyroid hormone a key regulator of fetal cardiomyocyte proliferation?
    Kent Thornburg; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): The developing fetal heart grows primarily by proliferation of all cell types, including cardiomyocytes...
  36. NONA Garment Project: Noninvasive Observation of Natal Activity
    AARON ROOD; Fiscal Year: 2009
    ..data from a set of women in the birthing center at TUFTS- New England Medical Center, and " demonstrated fetal heart rate and components of FECG can be identified accurately using Kalman Filtering relative to the available truth ..
  37. Simultaneous fetal echocardiography and magnetocardiography
    DOUGLAS PAULSON; Fiscal Year: 2009
    ..Vector coils are needed to ensure that the (arbitrarily positioned) fetal heart can be detected with reasonable signal strength...
  38. CELLULAR MECHANISMS OF AUTOIMMUNE ASSOCIATED CONGENITAL
    Mohamed Boutjdir; Fiscal Year: 1999
    ..Also, affinity purified anti-SSA/52kD Ro caused complete AV block in human fetal heart perfused by the Langendorff technique...
  39. The Monolithic Fetal Pacemaker: Prototype and Deployment
    DANIEL ZAVITZ; Fiscal Year: 2001
    ..capable of intrauterine placement, that avoids the problems incident to an exposed lead This is applicable to fetal heart block, where pacing for 2- 4 weeks prior to Cesarean delivery should resolve hydrops fetalis permitting ..
  40. HEART RATE DURING TRANSITION TO EXTRAUTERINE LIFE
    M Verklan; Fiscal Year: 2001
    ..The overriding objective in the companion application titled "Spectral and Nonlinear Analysis of the Fetal Heart Rate" is to identify any alterations of the power spectral density (PSD) during labor and delivery, and ..
  41. Fetal Magnetocardiography Using Non-cryogenic Magnetic Field Sensors
    VISHAL K SHAH; Fiscal Year: 2013
    ..efficacy of fetal magnetocardiography (fMCG), the magnetic analog of fetal ECG, as a new method of assessing fetal heart rate, rhythm, and conduction...
  42. REGULATION OF HEART RATE VARIABILITY IN HYPOXIC FETUSES
    Deborah Reid; Fiscal Year: 1992
    The variability of fetal heart rate is an important clinical indicator of fetal well-being. The study of the regulation of heart rate variability in the compromised fetus has been seriously hampered by the lack of a good animal model...
  43. ALPHA-1 ADRENERGIC REGULATION OF CARDIAC GENE EXPRESSION
    Paul Simpson; Fiscal Year: 1999
    ..in the context of a viral promoter, gene knockout has shown that TEF-1 is indispensable for growth of the fetal heart in vivo. The applicant has cloned TEF-1 from rat cardiac myocytes...
  44. Fetal Reactivity and Maternal Psychopathology
    Eugene Emory; Fiscal Year: 2007
    ..During labour, fetal heart rate will be monitored and umbilical cord blood will be assayed for cortisol...
  45. ENDOCRINE CONTROL OF FETAL CARDIOVASCULAR DYNAMICS
    CECILIA CHEUNG; Fiscal Year: 2000
    ..during fetal development, and the molecular mechanisms underlying the hypoxic induction of ANF expression in fetal heart. Primary cultures of atrial and ventricular myocytes from ovine fetuses at 60 to 145 days gestation will be ..
  46. GROWTH AND DIFFERENTIATION OF HUMAN CARDIOBLASTS
    DONALD KOHTZ; Fiscal Year: 1992
    ..proposal is concerned with the generation of a novel system for culturing cells from autopsy samples of human fetal heart. Rather than culturing cardiocytes, however, the proposed experiments will focus on culturing cardioblasts...
  47. GENERAL CLINICAL RESEARCH CENTER
    NEIL CHERNIACK; Fiscal Year: 1990
    ..have introduced new studies in the areas of high risk pregnancy, antepartum bioelectronic monitoring of fetal heart rate, movements and respirations, the prediction of low birth weight infant outcomes and the effect on the ..
  48. PSYCHOPHYSIOLOGICAL CORRELATES OF MATERNAL-FETAL HEALTH
    REGINA LEDERMAN; Fiscal Year: 1980
    ..A uterine monitor will be used to obtain a record of uterine contractile activity and fetal heart rate throughout labor. Uterine activity will be quantified with the use of a microcomputer system...
  49. PERINATAL VITAL SIGNS MONITOR
    David Sherman; Fiscal Year: 1999
    ..Electronic fetal heart rate monitoring (EFM) is widely used, yet it has not been shown to result in a significant decrease in the ..
  50. The significance of an antenatal nuchal cord
    JAMES CLAPP; Fiscal Year: 2005
    ..incidence of clinical intervention for the indication of fetal distress, presence or absence of meconium, the fetal heart rate pattern, birth weight for gestational age, nuchal cord at birth, Apgar scores, amniotic fluid ..
  51. HYPOXIA, IGFBP-1, AND HUMAN FETAL GROWTH
    Linda Giudice; Fiscal Year: 2003
    ..We have found in vitro that human fetal hepatocytes and explants of human fetal heart and kidney respond to hypoxia by increased IGFBP-1 mRNA expression and protein secretion...
  52. FETAL RESPONSIVITY DURING LABOR & BEHAVIORAL OUTCOME
    Eugene Emory; Fiscal Year: 1993
    ..has been conceived as an in-depth study of short-term and long-term behavioral correlates of intrapartum fetal heart rate (FHR) patterns among humans...
  53. MECHANISMS OF FETAL GROWTH RETARDATION
    Kenneth Clark; Fiscal Year: 1992
    ..01) between uteroplacental blood flow and ponderal index, feta body weight, fetal heart and thymus weights and placental weight...
  54. CONGENITAL MICROCEPHALY
    Alan Leviton; Fiscal Year: 1993
    ..If babies with congenital microcephaly are more likely than their peers to display ominous fetal heart patterns, low Apgar scores and need for ventilatory assistance, then these perinatal problems might reflect ..
  55. Novel fetal heart monitor technology
    WAYNE STERNBERGER; Fiscal Year: 2005
    ..In this regard, the development of the new fetal heart rate technology not only has significant commercial potential, but offers the research community new tools to ..
  56. Image-guided Fetal Cardiac Intervention
    John Triedman; Fiscal Year: 2005
    ..to the dimensions and material properties of fetal tissue, and the precision and speed with which access to the fetal heart can be obtained...
  57. Developing Instrumentation for Fetal Cardiac Monitoring
    DOUGLAS PAULSON; Fiscal Year: 2003
    ..fMCG is also a nearly ideal signal source for fetal heart rate monitoring, providing a precise signal, which can be detected throughout the last half of pregnancy...
  58. NEUROHUMORAL CONTROLS OF CARDIAC DEVELOPMENT
    Diane Tucker; Fiscal Year: 1991
    ..5. Thyroid hormone promotes growth, differentiation and intrinsic beating rate of fetal heart cultured in oculo both by direct action and by increasing sensitivity to sympathetic stimulation...
  59. INTRAUTERINE ELECTRODE ARRAY FOR DETERMINATION OF FHR
    Thomas Frank; Fiscal Year: 1992
    A pilot study is proposed to develop and clinically test a novel intrauterine electrode array for monitoring fetal heart rate and heart rate variability before and during labor...
  60. Functional basis of bradycardia in congenital heart bloc
    Yongxia Qu; Fiscal Year: 2005
    ..3. To identify the expression of Ca channel alphalD subunit in human fetal heart SA node cells...
  61. AN OPTIMAL FETAL HEART MONITOR
    RICHARD LONGINI; Fiscal Year: 1980
    ..Ultimately this may aid in screening for cardiac development abnormalities. ..
  62. NFAT regulation of embryonic cardiac metabolism
    PAUL BUSHDID; Fiscal Year: 2003
    ..The contribution of mitochondrial mitopathies to fetal heart failure has not been previously investigated...
  63. The Neonatal Heart: An Interactive Educational Program
    THOMAS MCCRACKEN; Fiscal Year: 2004
    Based on the results of Phase I, we have 4 aims. The first is the creation of new neonatal/fetal heart models, animations and video from unique data sets and sources including the cardiac conductive system...