heart

Summary

Summary: The hollow, muscular organ that maintains the circulation of the blood.

Top Publications

  1. ncbi Adult cardiac stem cells are multipotent and support myocardial regeneration
    Antonio P Beltrami
    Cardiovascular Research Institute, Department of Medicine, New York Medical College, Valhalla, NY 10595, USA
    Cell 114:763-76. 2003
  2. pmc ChIP-Seq identification of weakly conserved heart enhancers
    Matthew J Blow
    Genomics Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA
    Nat Genet 42:806-10. 2010
  3. ncbi Heart rate variability: origins, methods, and interpretive caveats
    G G Berntson
    Department of Psychology, Ohio State University, Columbus 43210, USA
    Psychophysiology 34:623-48. 1997
  4. pmc Zebrafish heart regeneration occurs by cardiomyocyte dedifferentiation and proliferation
    Chris Jopling
    Center of Regenerative Medicine in Barcelona, Spain
    Nature 464:606-9. 2010
  5. ncbi Isl1 identifies a cardiac progenitor population that proliferates prior to differentiation and contributes a majority of cells to the heart
    Chen Leng Cai
    Institute of Molecular Medicine, Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA
    Dev Cell 5:877-89. 2003
  6. ncbi Standardized myocardial segmentation and nomenclature for tomographic imaging of the heart. A statement for healthcare professionals from the Cardiac Imaging Committee of the Council on Clinical Cardiology of the American Heart Association
    Manuel D Cerqueira
    American Society of Nuclear Cardiology, USA
    Circulation 105:539-42. 2002
  7. pmc Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure
    Takafumi Oka
    Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
    Nature 485:251-5. 2012
  8. pmc Heart repair by reprogramming non-myocytes with cardiac transcription factors
    Kunhua Song
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, Texas 75390 9148, USA
    Nature 485:599-604. 2012
  9. pmc MicroRNAs are aberrantly expressed in hypertrophic heart: do they play a role in cardiac hypertrophy?
    Yunhui Cheng
    Cardiovascular Research Laboratory, Vascular Biology Center and Department of Surgery, University of Tennessee Health Science Center, 956 Court Avenue, Memphis, TN 38163, USA
    Am J Pathol 170:1831-40. 2007
  10. pmc MicroRNA-208a is a regulator of cardiac hypertrophy and conduction in mice
    Thomas E Callis
    Carolina Cardiovascular Biology Center, University of North Carolina, Chapel Hill, North Carolina, USA
    J Clin Invest 119:2772-86. 2009

Detail Information

Publications310 found, 100 shown here

  1. ncbi Adult cardiac stem cells are multipotent and support myocardial regeneration
    Antonio P Beltrami
    Cardiovascular Research Institute, Department of Medicine, New York Medical College, Valhalla, NY 10595, USA
    Cell 114:763-76. 2003
    The notion of the adult heart as terminally differentiated organ without self-renewal potential has been undermined by the existence of a subpopulation of replicating myocytes in normal and pathological states...
  2. pmc ChIP-Seq identification of weakly conserved heart enhancers
    Matthew J Blow
    Genomics Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA
    Nat Genet 42:806-10. 2010
    Accurate control of tissue-specific gene expression plays a pivotal role in heart development, but few cardiac transcriptional enhancers have thus far been identified...
  3. ncbi Heart rate variability: origins, methods, and interpretive caveats
    G G Berntson
    Department of Psychology, Ohio State University, Columbus 43210, USA
    Psychophysiology 34:623-48. 1997
    Components of heart rate variability have attracted considerable attention in psychology and medicine and have become important dependent measures in psychophysiology and behavioral medicine...
  4. pmc Zebrafish heart regeneration occurs by cardiomyocyte dedifferentiation and proliferation
    Chris Jopling
    Center of Regenerative Medicine in Barcelona, Spain
    Nature 464:606-9. 2010
    ..vertebrate species are able to regenerate their hearts, including the zebrafish, which can fully regenerate its heart after amputation of up to 20% of the ventricle...
  5. ncbi Isl1 identifies a cardiac progenitor population that proliferates prior to differentiation and contributes a majority of cells to the heart
    Chen Leng Cai
    Institute of Molecular Medicine, Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA
    Dev Cell 5:877-89. 2003
    ..Isl1 function is required for these progenitors to contribute to the heart. In isl1 mutants, isl1-expressing progenitors are progressively reduced in number, and FGF and BMP growth factors ..
  6. ncbi Standardized myocardial segmentation and nomenclature for tomographic imaging of the heart. A statement for healthcare professionals from the Cardiac Imaging Committee of the Council on Clinical Cardiology of the American Heart Association
    Manuel D Cerqueira
    American Society of Nuclear Cardiology, USA
    Circulation 105:539-42. 2002
  7. pmc Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure
    Takafumi Oka
    Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
    Nature 485:251-5. 2012
    b>Heart failure is a leading cause of morbidity and mortality in industrialized countries...
  8. pmc Heart repair by reprogramming non-myocytes with cardiac transcription factors
    Kunhua Song
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, Texas 75390 9148, USA
    Nature 485:599-604. 2012
    The adult mammalian heart possesses little regenerative potential following injury...
  9. pmc MicroRNAs are aberrantly expressed in hypertrophic heart: do they play a role in cardiac hypertrophy?
    Yunhui Cheng
    Cardiovascular Research Laboratory, Vascular Biology Center and Department of Surgery, University of Tennessee Health Science Center, 956 Court Avenue, Memphis, TN 38163, USA
    Am J Pathol 170:1831-40. 2007
    ..Although miRNAs are highly expressed in the heart, their roles in heart diseases are currently unclear...
  10. pmc MicroRNA-208a is a regulator of cardiac hypertrophy and conduction in mice
    Thomas E Callis
    Carolina Cardiovascular Biology Center, University of North Carolina, Chapel Hill, North Carolina, USA
    J Clin Invest 119:2772-86. 2009
    ..Here, we investigated the function and molecular mechanisms of the miR-208 family of miRNAs in adult mouse heart physiology...
  11. ncbi Postnatal isl1+ cardioblasts enter fully differentiated cardiomyocyte lineages
    Karl Ludwig Laugwitz
    Institute of Molecular Medicine, University of California, San Diego, School of Medicine, La Jolla, California 92093, USA
    Nature 433:647-53. 2005
    ..Until now there has been little evidence for native cardiac precursor cells in the postnatal heart. Herein, we report the identification of isl1+ cardiac progenitors in postnatal rat, mouse and human myocardium...
  12. pmc Hippo pathway inhibits Wnt signaling to restrain cardiomyocyte proliferation and heart size
    Todd Heallen
    Institute of Biosciences and Technology, Texas A and M System Health Science Center, 2121 West Holcombe Boulevard, Houston, TX 77030, USA
    Science 332:458-61. 2011
    Genetic regulation of mammalian heart size is poorly understood. Hippo signaling represents an organ-size control pathway in Drosophila, where it also inhibits cell proliferation and promotes apoptosis in imaginal discs...
  13. pmc Large-scale discovery of enhancers from human heart tissue
    Dalit May
    Genomics Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA
    Nat Genet 44:89-93. 2012
    Development and function of the human heart depend on the dynamic control of tissue-specific gene expression by distant-acting transcriptional enhancers...
  14. pmc Heart regeneration
    Michael A Laflamme
    Department of Pathology, Center for Cardiovascular Biology, Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, Washington 98109, USA
    Nature 473:326-35. 2011
    b>Heart failure plagues industrialized nations, killing more people than any other disease...
  15. ncbi Fate of the mammalian cardiac neural crest
    X Jiang
    Departments of Biological Sciences and Cell and Neurobiology, Institute for Genetic Medicine, Keck School of Medicine, University of Southern California, IGM 240, Los Angeles, CA 90033, USA
    Development 127:1607-16. 2000
    ..Labeling is highly specific and highly efficient. In the region of the heart, neural-crest-derived cells surround the pharyngeal arch arteries from the time of their formation and undergo an ..
  16. pmc NADPH oxidase 4 (Nox4) is a major source of oxidative stress in the failing heart
    Junya Kuroda
    Department of Cell Biology and Molecular Medicine, Cardiovascular Research Institute, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ 07103, USA
    Proc Natl Acad Sci U S A 107:15565-70. 2010
    ..To elucidate the function of endogenous Nox4 in the heart, we generated cardiac-specific Nox4(-/-) (c-Nox4(-/-)) mice...
  17. ncbi Myocardial matrix remodeling and the matrix metalloproteinases: influence on cardiac form and function
    Francis G Spinale
    Division of Cardiothoracic Surgery, Medical University of South Carolina, Charleston, South Carolina 29403, USA
    Physiol Rev 87:1285-342. 2007
    ..that directly contribute to adverse myocardial remodeling following myocardial infarction (MI), with hypertensive heart disease and with intrinsic myocardial disease such as cardiomyopathy...
  18. ncbi A model for human ventricular tissue
    K H W J ten Tusscher
    Department of Theoretical Biology, Utrecht University, 3584 CH Utrecht, The Netherlands
    Am J Physiol Heart Circ Physiol 286:H1573-89. 2004
    ..We conclude that the proposed model reproduces a variety of electrophysiological behaviors and provides a basis for studies of reentrant arrhythmias in human ventricular tissue...
  19. ncbi Myocardial substrate metabolism in the normal and failing heart
    William C Stanley
    Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University, 10900 Euclid Ave, Cleveland, Ohio 44106 4970, USA
    Physiol Rev 85:1093-129. 2005
    The alterations in myocardial energy substrate metabolism that occur in heart failure, and the causes and consequences of these abnormalities, are poorly understood...
  20. pmc Therapeutic inhibition of miR-208a improves cardiac function and survival during heart failure
    Rusty L Montgomery
    miRagen Therapeutics, Inc, Boulder, CO 80301, USA
    Circulation 124:1537-47. 2011
    ..Whether this miRNA might contribute to diastolic dysfunction or other forms of heart disease is currently unknown.
  21. ncbi Be smart, exercise your heart: exercise effects on brain and cognition
    Charles H Hillman
    Charles H Hillman is at the Department of Kinesiology and Community Health, 213 Louise Freer Hall, 906 South Goodwin Avenue, University of Illinois, Urbana, Illinois 61801, USA
    Nat Rev Neurosci 9:58-65. 2008
    ..A growing number of studies support the idea that physical exercise is a lifestyle factor that might lead to increased physical and mental health throughout life...
  22. pmc Transient regenerative potential of the neonatal mouse heart
    Enzo R Porrello
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Science 331:1078-80. 2011
    ..retain a robust capacity for cardiac regeneration throughout life, but the same is not true of the adult mammalian heart. Whether the capacity for cardiac regeneration is absent in mammals or whether it exists and is switched off early ..
  23. ncbi Neovascularization of ischemic myocardium by human bone-marrow-derived angioblasts prevents cardiomyocyte apoptosis, reduces remodeling and improves cardiac function
    A A Kocher
    Department of Surgery, Columbia University, New York, New York, USA
    Nat Med 7:430-6. 2001
    Left ventricular remodeling is a major cause of progressive heart failure and death after myocardial infarction...
  24. ncbi The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress
    Atsuko Nakai
    Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita Osaka 565 0871, Japan
    Nat Med 13:619-24. 2007
    ..Although altered autophagy has been observed in various heart diseases, including cardiac hypertrophy and heart failure, it remains unclear whether autophagy plays a beneficial ..
  25. pmc Primary contribution to zebrafish heart regeneration by gata4(+) cardiomyocytes
    Kazu Kikuchi
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nature 464:601-5. 2010
    ..By contrast, zebrafish efficiently regenerate lost cardiac muscle, providing a model for understanding how natural heart regeneration may be blocked or enhanced...
  26. ncbi Differentiation of human embryonic stem cells to cardiomyocytes: role of coculture with visceral endoderm-like cells
    Christine Mummery
    Hubrecht Laboratory, University Medical Center Utrecht, Utrecht, The Netherlands
    Circulation 107:2733-40. 2003
    Cardiomyocytes derived from human embryonic stem (hES) cells could be useful in restoring heart function after myocardial infarction or in heart failure...
  27. pmc Mitogen-activated protein kinase signaling in the heart: angels versus demons in a heart-breaking tale
    Beth A Rose
    Departments of Anesthesiology, Physiology, and Medicine, David Geffen School of Medicine, Molecular Biology, Institute, University of California at Los Angeles, Los Angeles, CA 90095, USA
    Physiol Rev 90:1507-46. 2010
    ..literature from these efforts has not yet resulted in a clear view about the roles of specific MAPK pathways in heart. Rather, controversies from contradictive results have led to a perception that MAPKs are ambiguous characters in ..
  28. pmc High-fat-diet-induced obesity and heart dysfunction are regulated by the TOR pathway in Drosophila
    Ryan T Birse
    NASCR Center, Sanford Burnham Medical Research Institute, La Jolla, CA 92037, USA
    Cell Metab 12:533-44. 2010
    ..We conclude that deregulation of insulin-TOR signaling due to a HFD is responsible for mediating the detrimental effects on metabolism and heart function.
  29. ncbi Cardiac excitation-contraction coupling
    Donald M Bers
    Department of Physiology, Stritch School of Medicine, Loyola Unversity Chicago, IL 60153, USA
    Nature 415:198-205. 2002
    Of the ions involved in the intricate workings of the heart, calcium is considered perhaps the most important...
  30. pmc Low-frequency power of heart rate variability is not a measure of cardiac sympathetic tone but may be a measure of modulation of cardiac autonomic outflows by baroreflexes
    David S Goldstein
    Clinical Neurocardiology Section, Clinical Neurosciences Program, Division of Intramural Research, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1620, USA
    Exp Physiol 96:1255-61. 2011
    Power spectral analysis of heart rate variability has often been used to assess cardiac autonomic function; however, the relationship of low-frequency (LF) power of heart rate variability to cardiac sympathetic tone has been unclear...
  31. ncbi Transplantation of Progenitor Cells and Regeneration Enhancement in Acute Myocardial Infarction (TOPCARE-AMI)
    Birgit Assmus
    Department of Molecular Cardiology, University of Frankfurt, Frankfurt, Germany
    Circulation 106:3009-17. 2002
    ..The safety and feasibility of autologous progenitor cell transplantation in patients with ischemic heart disease is unknown.
  32. ncbi Pericardial fat, visceral abdominal fat, cardiovascular disease risk factors, and vascular calcification in a community-based sample: the Framingham Heart Study
    Guido A Rosito
    Cardiac MR CT PET Program, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, USA
    Circulation 117:605-13. 2008
    ..Correlations with cardiovascular disease risk factors and vascular calcification in a community-based sample are lacking. We sought to examine associations between pericardial fat, metabolic risk factors, and vascular calcification...
  33. ncbi Control of stress-dependent cardiac growth and gene expression by a microRNA
    Eva van Rooij
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9148, USA
    Science 316:575-9. 2007
    The heart responds to diverse forms of stress by hypertrophic growth accompanied by fibrosis and eventual diminution of contractility, which results from down-regulation of alpha-myosin heavy chain (alphaMHC) and up-regulation of betaMHC,..
  34. ncbi Requirement of the transcription factor GATA4 for heart tube formation and ventral morphogenesis
    J D Molkentin
    Department of Molecular Biology and Oncology, University of Texas Southwestern Medical Center at Dallas, 75235 9148, USA
    Genes Dev 11:1061-72. 1997
    The zinc finger transcription factor GATA4 has been implicated in heart development based on its early expression in precardiogenic splanchnic mesoderm and its ability to activate the expression of a number of cardiac-specific genes...
  35. pmc A postnatal switch of CELF and MBNL proteins reprograms alternative splicing in the developing heart
    Auinash Kalsotra
    Department of Pathology, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 105:20333-8. 2008
    ..identified 63 alternative splicing (AS) events that are coordinated in 3 distinct temporal patterns during mouse heart development. More than half of these splicing transitions are evolutionarily conserved between mouse and chicken...
  36. ncbi Intracardiac fluid forces are an essential epigenetic factor for embryonic cardiogenesis
    Jay R Hove
    Options of Bioengineering and Aeronautics, Division of Engineering and Applied Science, California Institute of Technology, Pasadena, California 91125, USA
    Nature 421:172-7. 2003
    The pattern of blood flow in the developing heart has long been proposed to play a significant role in cardiac morphogenesis...
  37. ncbi Cardiac hypertrophy: the good, the bad, and the ugly
    N Frey
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9148, USA
    Annu Rev Physiol 65:45-79. 2003
    Cardiac hypertrophy is the heart's response to a variety of extrinsic and intrinsic stimuli that impose increased biomechanical stress...
  38. ncbi Cardiac fibroblasts: at the heart of myocardial remodeling
    Karen E Porter
    Multidisciplinary Cardiovascular Research Centre MCRC, Division of Cardiovascular and Neuronal Remodelling, Leeds Institute of Genetics, Health and Therapeutics LIGHT, University of Leeds, Leeds LS29JT, UK
    Pharmacol Ther 123:255-78. 2009
    Cardiac fibroblasts are the most prevalent cell type in the heart and play a key role in regulating normal myocardial function and in the adverse myocardial remodeling that occurs with hypertension, myocardial infarction and heart ..
  39. ncbi Human ISL1 heart progenitors generate diverse multipotent cardiovascular cell lineages
    Lei Bu
    Cardiovascular Research Center, Massachusetts General Hospital, Charles River Plaza CPZN 3208, 185 Cambridge Street, Boston, Massachusetts 02114, USA
    Nature 460:113-7. 2009
    ..cardiovascular cell lineages is a critical step during human cardiogenesis, with major implications for congenital heart disease...
  40. pmc Co-occupancy by multiple cardiac transcription factors identifies transcriptional enhancers active in heart
    Aibin He
    Department of Cardiology and Children s Hospital Informatics Program, Children s Hospital Boston, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 108:5632-7. 2011
    ..TFs and p300-bound regions were associated with cardiac-enriched genes and with functional annotations related to heart development...
  41. ncbi Serum response factor regulates a muscle-specific microRNA that targets Hand2 during cardiogenesis
    Yong Zhao
    Department of Pediatrics Cardiology, University of Texas Southwestern Medical Center and Children s Medical Center Dallas, 6000 Harry Hines Boulevard, Dallas, Texas 75390 9148, USA
    Nature 436:214-20. 2005
    ..Correspondingly, excess miR-1 in the developing heart leads to a decreased pool of proliferating ventricular cardiomyocytes...
  42. ncbi Modified Look-Locker inversion recovery (MOLLI) for high-resolution T1 mapping of the heart
    Daniel R Messroghli
    BHF Cardiac MRI Unit, Leeds General Infirmary, Leeds, UK
    Magn Reson Med 52:141-6. 2004
    ..We calculated T1 using signal intensities from regions of interest and pixel by pixel. T1 accuracy at different heart rates derived from simulated ECG signals was tested in phantoms...
  43. ncbi Making or breaking the heart: from lineage determination to morphogenesis
    Deepak Srivastava
    Gladstone Institute of Cardiovascular Disease and Department of Pediatrics and Biochemistry, University of California, San Francisco, CA 94158, USA
    Cell 126:1037-48. 2006
    ..Several themes are emerging that are relevant for childhood and adult heart disease and the growing field of stem cell biology...
  44. ncbi Acupuncture-like stimulation at auricular point Heart evokes cardiovascular inhibition via activating the cardiac-related neurons in the nucleus tractus solitarius
    Xin Yan Gao
    Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, 16 Nanxiaojie Street, Dongzhimennei, Beijing 100700, PR China
    Brain Res 1397:19-27. 2011
    ..tractus solitarius (NTS) in the regulation of cardiovascular inhibition during acupuncture at the auricular point Heart, single unit recording was made in anesthetized Sprague-Dawley rats...
  45. pmc Directed transdifferentiation of mouse mesoderm to heart tissue by defined factors
    Jun K Takeuchi
    Gladstone Institute of Cardiovascular Disease, San Francisco, California 94158, USA
    Nature 459:708-11. 2009
    b>Heart disease is the leading cause of mortality and morbidity in the western world. The heart has little regenerative capacity after damage, leading to much interest in understanding the factors required to produce new cardiac myocytes...
  46. ncbi Transcontinental and translational high-tech acupuncture research using computer-based heart rate and "Fire of Life" heart rate variability analysis
    Gerhard Litscher
    Unit of Biomedical Engineering in Anesthesia and Intensive Care Medicine, TCM Research Center Graz, Medical University of Graz, Auenbruggerplatz 29, Austria
    J Acupunct Meridian Stud 3:156-64. 2010
    ..Today, new computer-based methods (e.g., "Fire of Life" analysis) allow quantification of heart rate and heart rate variability during acupuncture...
  47. ncbi A murine model of Holt-Oram syndrome defines roles of the T-box transcription factor Tbx5 in cardiogenesis and disease
    B G Bruneau
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Cell 106:709-21. 2001
    ..decreased expression of multiple genes and caused severe hypoplasia of posterior domains in the developing heart. Surprisingly, Tbx5 haploinsufficiency also markedly decreased atrial natriuretic factor (ANF) and connexin 40 (..
  48. ncbi Tie2-Cre transgenic mice: a new model for endothelial cell-lineage analysis in vivo
    Y Y Kisanuki
    Department of Molecular Genetics, Howard Hughes Medical Institute, Dallas, Texas, 75390 9050, USA
    Dev Biol 230:230-42. 2001
    ..Tie2-Cre transgenic mice are a new genetic tool for the analyses of endothelial cell-lineage and endothelial cell-specific gene targeting...
  49. pmc Repair of acute myocardial infarction by human stemness factors induced pluripotent stem cells
    Timothy J Nelson
    Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Circulation 120:408-16. 2009
    ..Induced pluripotent stem cells (iPS) demonstrate aptitude for de novo cardiac differentiation, yet their potential for heart disease therapy has not been tested.
  50. ncbi Mice deficient for BMP2 are nonviable and have defects in amnion/chorion and cardiac development
    H Zhang
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Development 122:2977-86. 1996
    ..embryos also exhibited a defect in cardiac development, manifested by the abnormal development of the heart in the exocoelomic cavity...
  51. pmc Cardiomyocytes can be generated from marrow stromal cells in vitro
    S Makino
    Cardiopulmonary Division, Department of Internal Medicine, Keio University School of Medicine, Tokyo 160 8582, Japan
    J Clin Invest 103:697-705. 1999
    ..These cells expressed Nkx2.5/Csx, GATA4, TEF-1, and MEF-2C mRNA before 5-azacytidine treatment and expressed MEF-2A and MEF-2D after treatment. This new cell line provides a powerful model for the study of cardiomyocyte differentiation...
  52. pmc Altered expression of mitochondrial and extracellular matrix genes in the heart of human fetuses with chromosome 21 trisomy
    Anna Conti
    Dipartimento di Biologia e Patologia Cellulare e Molecolare, University Federico II, Napoli, Italy
    BMC Genomics 8:268. 2007
    ..Using oligonucleotide microarrays we compared the gene expression profiles of hearts of human fetuses with and without Hsa21 trisomy...
  53. ncbi Ischaemic preconditioning does not protect the heart in obese and lean animal models of type 2 diabetes
    S B Kristiansen
    Department of Cardiology, Skejby Sygehus, Aarhus University Hospital, Aarhus N, Denmark
    Diabetologia 47:1716-21. 2004
    ....
  54. ncbi Heart regeneration in zebrafish
    Kenneth D Poss
    Department of Cell Biology, Howard Hughes Medical Institute, Harvard Medical School, Children s Hospital, 320 Longwood Avenue, Boston, MA 02115, USA
    Science 298:2188-90. 2002
    Cardiac injury in mammals and amphibians typically leads to scarring, with minimal regeneration of heart muscle. Here, we demonstrate histologically that zebrafish fully regenerate hearts within 2 months of 20% ventricular resection...
  55. ncbi Transcriptional control of muscle development by myocyte enhancer factor-2 (MEF2) proteins
    B L Black
    Department of Molecular Biology and Oncology, University of Texas Southwestern Medical Center, Dallas 75235 9148, USA
    Annu Rev Cell Dev Biol 14:167-96. 1998
    ..We discuss the diverse functions of this family of transcription factors, the ways in which they are regulated, and their mechanisms of action...
  56. ncbi Cardiovascular complications of cancer therapy: diagnosis, pathogenesis, and management
    Edward T H Yeh
    Department of Cardiology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, Tex 77030 4095, USA
    Circulation 109:3122-31. 2004
    ..Further research will be required to more accurately predict which patients are at risk for developing cardiotoxicity. In addition, management plans, as well as strategies to reduce cardiotoxicity, need to be developed...
  57. ncbi Metabolism, hypoxia and the diabetic heart
    Lisa C Heather
    Cardiac Metabolism Research Group, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK
    J Mol Cell Cardiol 50:598-605. 2011
    The diabetic heart becomes metabolically remodelled as a consequence of exposure to abnormal circulating substrates and hormones...
  58. ncbi Pathogenesis of chronic Chagas heart disease
    Jose Antonio Marin-Neto
    Cardiology Division, Department of Internal Medicine, Medical School of Ribeirao Preto, University of Sao Paulo, Sao Paulo, Brazil
    Circulation 115:1109-23. 2007
    ..Despite nearly 1 century of research, the pathogenesis of chronic Chagas cardiomyopathy is incompletely understood, the most intriguing challenge of which is the complex host-parasite interaction...
  59. ncbi Diabetes blockade of sevoflurane postconditioning is not restored by insulin in the rat heart: phosphorylated signal transducer and activator of transcription 3- and phosphatidylinositol 3-kinase-mediated inhibition
    Benjamin Drenger
    Department of Anesthesiology and Critical Care Medicine, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Anesthesiology 114:1364-72. 2011
    ..To determine whether postC cardioprotection can be restored by normoglycemia, we treated rats with insulin...
  60. pmc Regulation of skin aging and heart development by TAp63
    M Paris
    L Oreal Recherche, Clichy, France
    Cell Death Differ 19:186-93. 2012
    ..The second study is related to the role of TAp63, expressed by the primitive endoderm, on heart development...
  61. pmc The regenerative capacity of zebrafish reverses cardiac failure caused by genetic cardiomyocyte depletion
    Jinhu Wang
    Department of Cell Biology and Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710, USA
    Development 138:3421-30. 2011
    Natural models of heart regeneration in lower vertebrates such as zebrafish are based on invasive surgeries causing mechanical injuries that are limited in size...
  62. ncbi NADPH oxidase inhibition ameliorates Trypanosoma cruzi-induced myocarditis during Chagas disease
    Monisha Dhiman
    Department of Microbiology and Immunology, Center for Tropical Diseases, University of Texas Medical Branch, Galveston, TX 77555 1070, USA
    J Pathol 225:583-96. 2011
    ..MHC, BNP, and ANP mRNA levels) and fibrosis (increased collagen, glycosaminoglycans, and lipid contents) of the heart during the chronic phase were controlled in apocynin-treated mice...
  63. ncbi Control of mouse cardiac morphogenesis and myogenesis by transcription factor MEF2C
    Q Lin
    Department of Molecular Biology and Oncology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75235 9148, USA
    Science 276:1404-7. 1997
    ..The murine MEF2C gene is expressed in heart precursor cells before formation of the linear heart tube...
  64. pmc Distinct phases of cardiomyocyte differentiation regulate growth of the zebrafish heart
    Emma de Pater
    Hubrecht Institute and University Medical Centre Utrecht, 3584 CT, Utrecht, The Netherlands
    Development 136:1633-41. 2009
    Amongst animal species, there is enormous variation in the size and complexity of the heart, ranging from the simple one-chambered heart of Ciona intestinalis to the complex four-chambered heart of lunged animals...
  65. ncbi How to make a heart: the origin and regulation of cardiac progenitor cells
    Stephane D Vincent
    Institut Pasteur, Departement de Biologie du Developpement, CNRS URA 2578, Paris, France
    Curr Top Dev Biol 90:1-41. 2010
    The formation of the heart is a complex morphogenetic process that depends on the spatiotemporally regulated contribution of cardiac progenitor cells...
  66. ncbi Glucagon-like peptide-1 infusion improves left ventricular ejection fraction and functional status in patients with chronic heart failure
    George G Sokos
    Department of Medicine, Allegheny General Hospital, Pittsburgh, Pennsylvania 15212, USA
    J Card Fail 12:694-9. 2006
    Insulin resistance is present in the setting of congestive heart failure. Glucagon-like peptide-1 (GLP-1) is a naturally occurring incretin with both insulinotropic and insulinomimetic properties.
  67. ncbi Myocyte turnover in the aging human heart
    Jan Kajstura
    Department of Anesthesia and Medicine and Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Circ Res 107:1374-86. 2010
    The turnover of cardiomyocytes in the aging female and male heart is currently unknown, emphasizing the need to define human myocardial biology.
  68. ncbi Vagal tone dominates autonomic control of mouse heart rate at thermoneutrality
    S J Swoap
    Dept of Biomedical Sciences, Florida State University, Tallahassee, FL 32306 4300, USA
    Am J Physiol Heart Circ Physiol 294:H1581-8. 2008
    It is generally accepted that cardiac sympathetic tone dominates the control of heart rate (HR) in mice...
  69. pmc Epicardial progenitors contribute to the cardiomyocyte lineage in the developing heart
    Bin Zhou
    Harvard Stem Cell Institute and Department of Cardiology, Children s Hospital Boston, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nature 454:109-13. 2008
    The heart is formed from cardiogenic progenitors expressing the transcription factors Nkx2-5 and Isl1 (refs 1 and 2)...
  70. pmc GLP-1R agonist liraglutide activates cytoprotective pathways and improves outcomes after experimental myocardial infarction in mice
    Mohammad Hossein Noyan-Ashraf
    Toronto General Hospital, Toronto, Ontario, Canada
    Diabetes 58:975-83. 2009
    ..However, the consequences of GLP-1R activation before ischemic myocardial injury remain unclear...
  71. pmc Physical interaction between TBX5 and MEF2C is required for early heart development
    Tushar K Ghosh
    Institute of Genetics, School of Biology, University of Nottingham, Queen s Medical Centre, Nottingham, United Kingdom
    Mol Cell Biol 29:2205-18. 2009
    TBX5 is a transcription factor which plays important roles in the development of the heart and upper limbs. Mutations in this gene produce the inherited disorder Holt-Oram syndrome...
  72. ncbi Angiotensin-converting enzyme 2 is an essential regulator of heart function
    Michael A Crackower
    Amgen Research Institute Ontario Cancer Institute and Department of Medical Biophysics and Immunology, University of Toronto, University Avenue, Toronto, Ontario M5G 2M9, Canada
    Nature 417:822-8. 2002
    ..cardiac contractility defect, increased angiotensin II levels, and upregulation of hypoxia-induced genes in the heart. Genetic ablation of ACE on an ACE2 mutant background completely rescues the cardiac phenotype...
  73. ncbi Gene regulatory networks in the evolution and development of the heart
    Eric N Olson
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390, USA
    Science 313:1922-7. 2006
    The heart, an ancient organ and the first to form and function during embryogenesis, evolved by the addition of new structures and functions to a primitive pump...
  74. ncbi Role of hydrogen sulfide in the cardioprotection caused by ischemic preconditioning in the rat heart and cardiac myocytes
    Jin Song Bian
    Cardiovascular Biology Research Group, Department of Pharmacology, Yong Loo Lin School of Medicine, Singapore
    J Pharmacol Exp Ther 316:670-8. 2006
    Endogenous H(2)S is synthesized mainly by cystathionine gamma-lyase in the heart. The present study investigated the role of H(2)S in cardioprotection induced by ischemic preconditioning...
  75. pmc Generation of functional ventricular heart muscle from mouse ventricular progenitor cells
    Ibrahim J Domian
    Cardiovascular Research Center, Massachusetts General Hospital, Charles River Plaza, CPZN 3200, 185 Cambridge Street, Boston, MA 02114 2790, USA
    Science 326:426-9. 2009
    The mammalian heart is formed from distinct sets of first and second heart field (FHF and SHF, respectively) progenitors...
  76. pmc Comprehensive 4D velocity mapping of the heart and great vessels by cardiovascular magnetic resonance
    Michael Markl
    Department of Radiology, Medical Physics, University Hospital Freiburg, Germany
    J Cardiovasc Magn Reson 13:7. 2011
    ..components of the velocities of blood flow relative to the three spatial dimensions and the time course of the heart cycle...
  77. ncbi Claude Bernard and the heart-brain connection: further elaboration of a model of neurovisceral integration
    Julian F Thayer
    The Ohio State University, Department of Psychology, 1835 Neil Avenue, Columbus, OH 43210, USA
    Neurosci Biobehav Rev 33:81-8. 2009
    The intimate connection between the brain and the heart was enunciated by Claude Bernard over 150 years ago. In our neurovisceral integration model we have tried to build on this pioneering work...
  78. ncbi Physiological background of the loss of fractal heart rate dynamics
    Mikko P Tulppo
    Merikoski Rehabilitation and Research Centre, Kasarmintie 13, PO Box 404, FIN 90101 Oulu, Finland
    Circulation 112:314-9. 2005
    Altered fractal heart rate (HR) dynamics occur during various disease states, but the physiological background of abnormal fractal HR behavior is not well known...
  79. pmc Genome-wide discovery of human heart enhancers
    Leelavati Narlikar
    Computational Biology Branch, National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health NIH, Bethesda, Maryland 20894, USA
    Genome Res 20:381-92. 2010
    ..Using heart development as an experimental framework, we employed a combination of Gibbs sampling and linear regression to ..
  80. pmc Modulation of energy transfer pathways between mitochondria and myofibrils by changes in performance of perfused heart
    Marko Vendelin
    Laboratory of Systems Biology, Institute of Cybernetics, Tallinn University of Technology, Akadeemia 21, 12618 Tallinn, Estonia
    J Biol Chem 285:37240-50. 2010
    In the heart, the energy supplied by mitochondria to myofibrils is continuously and finely tuned to the contraction requirement over a wide range of cardiac loads...
  81. ncbi Xenografted human amniotic membrane-derived mesenchymal stem cells are immunologically tolerated and transdifferentiated into cardiomyocytes
    Hiroko Tsuji
    Department of Obstetrics, Keio University School of Medicine, Tokyo, Japan
    Circ Res 106:1613-23. 2010
    ..Amniotic membrane is known to have the ability to transdifferentiate into multiple organs and is expected to stimulate a reduced immunologic reaction...
  82. pmc Losartan decreases cardiac muscle fibrosis and improves cardiac function in dystrophin-deficient mdx mice
    Christopher F Spurney
    Division of Cardiology, Children s National Medical Center, Washington, DC, USA
    J Cardiovasc Pharmacol Ther 16:87-95. 2011
    ..Chronic treatment with losartan decreases cardiac and skeletal muscle fibrosis and improves cardiac systolic function in dystrophin-deficient mdx mice...
  83. pmc Heterogeneity of genetic modifiers ensures normal cardiac development
    Julia B Winston
    Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA
    Circulation 121:1313-21. 2010
    Mutations of the transcription factor Nkx2-5 cause pleiotropic heart defects with incomplete penetrance. This variability suggests that additional factors can affect or prevent the mutant phenotype...
  84. ncbi Fgf4 is required for left-right patterning of visceral organs in zebrafish
    Hajime Yamauchi
    Department of Genetic Biochemistry, Kyoto University Graduate School of Pharmaceutical Sciences, Sakyo, Kyoto 606 8501, Japan
    Dev Biol 332:177-85. 2009
    ..Randomized LR patterning of visceral organs including the liver, pancreas, and heart was observed in the knockdown embryos...
  85. ncbi Cardiac autonomic neural remodeling and susceptibility to sudden cardiac death: effect of endurance exercise training
    George E Billman
    Dept of Physiology and Cell Biology, The Ohio State Univ, Columbus, OH 43210 1218, USA
    Am J Physiol Heart Circ Physiol 297:H1171-93. 2009
    ..that endurance exercise training (treadmill running) enhanced cardiac parasympathetic regulation (increased heart rate variability), restored a more normal beta-adrenoceptor balance (i.e...
  86. pmc Myocardial regeneration by activation of multipotent cardiac stem cells in ischemic heart failure
    Konrad Urbanek
    Cardiovascular Research Institute, Department of Medicine, New York Medical College, Valhalla, NY 10595, USA
    Proc Natl Acad Sci U S A 102:8692-7. 2005
    In this study, we tested whether the human heart possesses a cardiac stem cell (CSC) pool that promotes regeneration after infarction...
  87. pmc Myofilament length dependent activation
    Pieter P de Tombe
    Department of Cell and Molecular Physiology, Stritch School of Medicine, Loyola University Chicago, Chicago, IL 60153, USA
    J Mol Cell Cardiol 48:851-8. 2010
    The Frank-Starling law of the heart describes the interrelationship between end-diastolic volume and cardiac ejection volume, a regulatory system that operates on a beat-to-beat basis...
  88. ncbi Bcl-2 engineered MSCs inhibited apoptosis and improved heart function
    Wenzhong Li
    Department of Cardiac Surgery, University Rostock, Schillingallee 69, Rostock, Germany
    Stem Cells 25:2118-27. 2007
    ..Our current findings support the premise that transplantation of antiapoptotic gene-modified MSCs may have values for mediating substantial functional recovery after acute myocardial infarction...
  89. ncbi Chimerism of the transplanted heart
    Federico Quaini
    Department of Medicine, New York Medical College, Valhalla 10595, USA
    N Engl J Med 346:5-15. 2002
    Cases in which a male patient receives a heart from a female donor provide an unusual opportunity to test whether primitive cells translocate from the recipient to the graft and whether cells with the phenotypic characteristics of those ..
  90. pmc Transgenic system for conditional induction and rescue of chronic myocardial hibernation provides insights into genomic programs of hibernation
    Dalit May
    Department of Molecular Biology, The Hebrew University Hadassah University Hospital, Jerusalem 91120, Israel
    Proc Natl Acad Sci U S A 105:282-7. 2008
    ..the coronary vasculature to match increased oxygen consumption and exploit this finding to generate a hypoperfused heart. Importantly, ensuing ischemia is tunable to a level at which large cohorts of cardiomyocytes are driven to enter ..
  91. ncbi Adult cardiac Sca-1-positive cells differentiate into beating cardiomyocytes
    Katsuhisa Matsuura
    Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, Chiba 260 8670, Japan
    J Biol Chem 279:11384-91. 2004
    ..have been reported to exist in various adult organs, there have been few reports concerning stem cells in the heart. We here demonstrate that Sca-1-positive (Sca-1+) cells in adult hearts have some of the features of stem cells...
  92. ncbi Hybrid systems analysis of the control of burst duration by low-voltage-activated calcium current in leech heart interneurons
    Andrey Olypher
    Department of Biology, Emory University, 1510 Clifton Road N E, Atlanta, GA 30322, USA
    J Neurophysiol 96:2857-67. 2006
    The leech heartbeat CPG is paced by the alternating bursting of pairs of mutually inhibitory heart interneurons that form elemental half-center oscillators...
  93. pmc SmyD1, a histone methyltransferase, is required for myofibril organization and muscle contraction in zebrafish embryos
    Xungang Tan
    Center of Marine Biotechnology, University of Maryland Biotechnology Institute, Baltimore, MD 21202, USA
    Proc Natl Acad Sci U S A 103:2713-8. 2006
    ..Together, these data indicate that SmyD1a and SmyD1b are histone methyltransferases and play a critical role in myofibril organization during myofiber maturation...
  94. ncbi Pharmacological activation of rapid delayed rectifier potassium current suppresses bradycardia-induced triggered activity in the isolated guinea pig heart
    Rie Schultz Hansen
    Neurosearch A S, Pederstrupvej 93, 2750 Ballerup, Denmark
    J Pharmacol Exp Ther 321:996-1002. 2007
    ..affects native I(Kr) and report the effects that activating this potassium current have in the intact guinea pig heart. In Langendorff-perfused hearts, the compound showed a concentration-dependent shortening of action potential ..
  95. ncbi Dominant negative suppression of Rad leads to QT prolongation and causes ventricular arrhythmias via modulation of L-type Ca2+ channels in the heart
    Hirotaka Yada
    Cardiopulmonary Division, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Circ Res 101:69-77. 2007
    ..Among these proteins, Rad (Ras associated with diabetes) is highly expressed in the heart, although its role in the heart remains unknown...
  96. ncbi Endocardium is necessary for cardiomyocyte movement during heart tube assembly
    Nathalia Glickman Holtzman
    Developmental Genetics Program and Department of Cell Biology, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    Development 134:2379-86. 2007
    Embryonic heart formation requires the union of bilateral populations of cardiomyocytes and their reorganization into a simple tube...
  97. pmc Genetic control of heart function and aging in Drosophila
    Karen Ocorr
    Burnham Institute for Medical Research, Program for Systems and Developmental Biology, Center for Neuroscienes and Aging, La Jolla, CA 92037, USA
    Trends Cardiovasc Med 17:177-82. 2007
    The Drosophila heart has proven itself to be an excellent model for human cardiac development and recent investigations suggest that it may serve as a model for human heart function as well...
  98. ncbi Force-length relations in isolated intact cardiomyocytes subjected to dynamic changes in mechanical load
    Gentaro Iribe
    Cardiac Mechano Electric Feedback Group, Dept of Physiology, Anatomy and Genetics, Univ of Oxford, Sherrington Bldg, Parks Road, Oxford, UK
    Am J Physiol Heart Circ Physiol 292:H1487-97. 2007
    ..transition between end-diastolic and end-systolic FL coordinates provides a valuable extension to the range of tools available for the study of single cardiomyocyte mechanics, to foster its interrelation with whole heart pathophysiology.
  99. pmc Serum response factor micromanaging cardiogenesis
    Zhivy Niu
    Program in Cardiovascular Sciences, Baylor College of Medicine, Houston, TX 77030, USA
    Curr Opin Cell Biol 19:618-27. 2007
    ..factor (SRF), a cardiac-enriched transcription factor, is required for the appearance of beating sarcomeres in the heart. SRF may also direct the expression of microRNAs (miRs) that inhibit the expression of cardiac regulatory factors...
  100. ncbi The sphingolipid transporter spns2 functions in migration of zebrafish myocardial precursors
    Atsuo Kawahara
    Department of Structural Analysis, National Cardiovascular Center Research Institute, Fujishirodai 5 7 1, Suita, Osaka 565 8565, Japan
    Science 323:524-7. 2009
    ..Thus, Spns2 in the YSL functions as a S1P transporter in S1P secretion, thereby regulating myocardial precursor migration...
  101. pmc Regulation of muscle development by DPF3, a novel histone acetylation and methylation reader of the BAF chromatin remodeling complex
    Martin Lange
    Group Cardiovascular Genetics, Department Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin 14195, Germany
    Genes Dev 22:2370-84. 2008
    ..We present DPF3, a new epigenetic key factor for heart and muscle development characterized by a double PHD finger...

Research Grants77

  1. Novel Mitochondrial Mechanisms of Ethanol-Induced Cardiac Injury in Aged Females
    DONNA HOPE KORZICK; Fiscal Year: 2010
    ..Greater vulnerability to alcoholic heart disease in women is exacerbated by evidence indicating that post-menopausal women have higher mortality rates ..
  2. Role of Txnip in adapting fuel metabolism to nutritional state
    SIMON HUI; Fiscal Year: 2013
    ..Results of this proposed research will provide fundamental information that may lead to better prevention and/or therapeutics for diabetes and cardiovascular disease in humans. ..
  3. Insulin Signaling and the Heart in Diabetes
    EVAN DALE ABEL; Fiscal Year: 2011
    ..of this award we demonstrated that myocardial insulin and IGF-1 signaling regulates mitochondrial function in the heart, and that insulin signaling is required for maintaining myocardial viability in the face of hemodynamic stressors ..
  4. Model of Timothy Syndrome to Screen Drugs with Induced Pluripotent Stem Cells
    Masayuki Yazawa; Fiscal Year: 2013
    ..To accomplish this goal, I have focused calcium signaling in heart function and development since undergraduate studies...
  5. Model of Timothy Syndrome to Screen Drugs with Induced Pluripotent Stem Cells
    Masayuki Yazawa; Fiscal Year: 2013
    ..To accomplish this goal, I have focused calcium signaling in heart function and development since undergraduate studies...
  6. Regulation of myocardial growth and death by GSK-3
    Junichi Sadoshima; Fiscal Year: 2013
    ..substantial influence on cardiac function when its activity is modulated by phosphorylation during hypertrophy and heart failure (HF)...
  7. Antiarrhythmic Mechanisms in the Hearts of Hibernating Mammals
    Lai Hua Xie; Fiscal Year: 2013
    ..We will assess Hypothesis 1 (in intact heart and at the tissue level): Woodchuck hearts exhibit greater resistance to ischemia-induced VF and SCD in winter...
  8. Gene Therapy with Cardiotropic Vectors for the Treatment of Heart Failure
    Roger J Hajjar; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Despite the proliferation of therapies, congestive heart failure (HF) remains a progressive disease...
  9. JNK exacerbates ischemia/reperfusion injury in hyperglycemic subjects.
    Keith A Webster; Fiscal Year: 2010
    ..Experiments are proposed to test this hypothesis in mouse models. If our hypothesis is correct we will described the molecular basis for this an begin to develop new approaches for treatment. ..
  10. Targeting Cell Death to Prevent Ventricular Remodeling and Heart Failure
    Abhinav Diwan; Fiscal Year: 2011
    ..that defines both myocardial infarction and the progression from compensated cardiac hypertrophy to decompensated heart failure is death of cardiomyocytes...
  11. Role of Glutathione S-Transferase P in Heart Failure
    Sumanth D Prabhu; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Although oxidative stress is a hallmark of heart failure (HF), clinical trials with antioxidants targeting first generation reactive oxygen species (ROS) such as O2/ and H2O2 have not yielded ..
  12. Mitochondrial and Nuclear Mechanisms of Estrogen Receptor-Mediated Cardioprotecti
    DONNA HOPE KORZICK; Fiscal Year: 2012
    ..Protective signaling pathways in the heart known to be influenced by E2 action include (PI3K)-Akt, eNOS and GSK3-2...
  13. Novel Zebrafish Models to Study Toxicity of PCBs and Pesticides During Pregnancy
    Lisa Satterwhite; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Hypoplastic left heart (HLH) is a grave congenital condition, uniformly fatal if untreated and requiring multiple surgeries for survival...
  14. Maternal Autoantibodies: Pathogenesis of Neonatal Lupus
    JILL PAMELA BUYON; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Identification of isolated congenital heart block (CHB) in a fetus predicts with near certainty that the mother, who may have a rheumatic disease or be asymptomatic, will have autoantibodies (Ab) to ..
  15. Novel Regenerative Therapy for Myocardial Infarction
    Andrew R Mendelsohn; Fiscal Year: 2011
    ..present with signs and symptoms of crushing chest pressure, diaphoresis, malignant ventricular arrhythmias, heart failure (HF), or shock. MI may also manifest as sudden cardiac death...
  16. Targeting GRK2 (BARK1) in Heart Failure
    Walter J Koch; Fiscal Year: 2013
    Targeting GRK2 ([unreadable]ARK1) in Heart Failure ABSTRACT Heart Failure (HF) continues to grow in the country and is a burden to the health care enterprise...
  17. AKAP Regulation of PKA Targeting in the Heart
    Meredith Bond; Fiscal Year: 2009
    ..kinase (PKA) by A-kinase anchoring proteins (AKAP) in isolated rat cardiac myocytes and in normal and failing rat heart and assesses the functional implications of disruption of PKA targeting...
  18. The unique role of B-Raf in murine cardiac development and postnatal function
    Natasha N Chattergoon; Fiscal Year: 2013
    ..maturation in the perinatal period and especially understanding the signaling mechanisms that govern this phase of heart development. I completed my M.S. and Ph.D...
  19. Role of Oxidative Stress in Post-MI Cardiac Failure Associated with Diabetes
    MICHAEL FREDERICK HILL; Fiscal Year: 2013
    ..excess mortality of diabetic MI patients has been demonstrated to result primarily from an increased incidence of heart failure (HF)...
  20. Sphingosine 1-phosphate and cardioprotection
    JOEL SAMUEL KARLINER; Fiscal Year: 2012
    ..Robert Raffao. These mice rapidly develop occlusive coronary atherosclerosis, myocardial infarction, heart failure, and premature death in response to high-fat feeding...
  21. Impact of AMP-activated kinase on sex differences in hypertrophic cardiomyopathy
    John P Konhilas; Fiscal Year: 2013
    ..by studying the physiological impact brought about by changes in the molecular and biochemical biology of the heart in response to disease and sex. Dr...
  22. Mouse Models of Non-Syndromic Cardiac Progeria
    Ali J Marian; Fiscal Year: 2012
    ..activity, telomere attrition and levels of p16INK4a, p21WAF1/CIP1, SA-2-Gal and markers of oxidative stress in the heart cardiac...
  23. Arrhythmia Mechanisms in Sarcomeric Cardiomyopathies
    Bjorn C Knollmann; Fiscal Year: 2012
    ..AIM 2: To determine the effect of myofilament Ca2+ sensitization on the ventricular action potential and its heart rate dependence AIM 3: To determine the effect of myofilament Ca2+ sensitization on cell-cell coupling and on ..
  24. Pulmonary Vascular-Right Ventricular Axis Research Program
    Wai Hong Wilson Tang; Fiscal Year: 2013
    ..the cardiomyocyte, where NO synthesis by eNOS is cardioprotective;but eNOS has not been studied in the human PAH heart. Activation of eNOS requires enzyme dephosphorylation at Threonine 495 (T495) and phosphorylation at Serine 1177 (..
  25. Inflammation and Repair in Cardiac Ischemia-Reperfusion
    Lewis C Becker; Fiscal Year: 2011
    The objective of this Program Project is to define the mechanisms of inflammation and repair in the heart after ischemia and reperfusion...
  26. Role of Mitochondria Targeted CYP2E1 and HO-1 in Alcohol Mediated Tissue Injury
    Narayan G Avadhani; Fiscal Year: 2012
    ..for increased mitochondrial import of CYP2E1 and HO-1 and the role of these proteins in alcohol-mediated liver and heart injury using a multi-prong approach: 1) Investigate the mechanistic roles of mitochondrial CYP2E1 and HO-1 in ROS ..
  27. Adjunctive Use of Apyrase to Fibrinolytic Therapy
    Ridong Chen; Fiscal Year: 2013
    ....
  28. Determinants of Disease Expression in Arrhythmogenic Cardiomyopathy
    Jeffrey E Saffitz; Fiscal Year: 2010
    ..Challenge Grant application is focused on arrhythmogenic right ventricular cardiomyopathy (ARVC), a rare primary heart muscle disorder characterized by a high incidence of serious ventricular tachyarrhythmias and sudden cardiac death,..
  29. Role of Lipoproteins in Chagasic heart disease
    JYOTHI FALGUNI NAGAJYOTHI; Fiscal Year: 2013
    ..Chagasic heart disease is characterized by myocarditis associated with prominent fibrotic scarring, cardiac hypertrophy, ..
  30. Cardiac dysfunction in StrepTSS: interplay of SLO and MMPs
    Dennis L Stevens; Fiscal Year: 2013
    ..pore-forming toxin produced by GAS, causes rapid and profound changes (1-5 min) in the ability of individual heart muscle cells to contract in response to electrical stimuli...
  31. Systems Analysis of Cardiac Chromatin Structure
    Thomas M Vondriska; Fiscal Year: 2013
    ..g. during disease)? Heart failure involves large-scale gene expression changes, including reactivation of genes normally silenced during ..
  32. Identification and Validation of Alcohol Biomarker Signatures by Proteomics
    Emanuel Rubin; Fiscal Year: 2010
    ..alcohol abusers display cardiac dysfunction, leading to dilated cardiomyopathy and eventually to congestive heart failure. Functionally, alcoholic cardiomyopathy (ACM) is characterized by reversible and irreversible alterations...
  33. Phospholemman and Cardiac Contracility
    Joseph Y Cheung; Fiscal Year: 2013
    ..in regulation of ion transport, modulates the function of both Na+-K+-ATPase and Na+/Ca2+ exchanger (NCX1) in the heart. In the current grant period, using 3 model systems (adenovirus-mediated gene transfer in adult rat myocytes, ..
  34. Modulation of Ca Control of Cardiac Myofibrils
    R John Solaro; Fiscal Year: 2013
    ..down-regulation of the slow skeletal troponin I (ssTnI) isoform, which occurs during post-natal maturation of the heart. Preliminary data underpin our hypothesis that the microRNA, miR-208a, is involved in silencing the cardiac ..
  35. Silencing cardiac-specific microRNAs to prevent pathological remodeling in conges
    MATTHEW SWAN LAWRENCE; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Heart disease remains the primary cause of morbidity and mortality in the industrialized world and continues to incur costs estimated at $30 billion per year, despite detailed understanding of the ..
  36. Mechanisms and Functions of Bimodally Targeted Cytochrome P450s to Mitochondria
    Narayan G Avadhani; Fiscal Year: 2012
    ..Finally, the role of mitochondria targeted CYPs in ischemia reperfusion injury will be studied using cell and animal models. ..
  37. Cardiac Regeneration through Growth Factor Eluting Microrod Scaffolds
    Paul H Goldspink; Fiscal Year: 2013
    Five million heart failure patients in the US have poor cardiac pumping due to irreversible damage of the contractile myocytes. Thus, recovery of cardiac function by cell and tissue engineering is highly desirable...
  38. MECHANISMS OF MALADAPTATION IN HEART FAILURE
    Howard A Rockman; Fiscal Year: 2013
    ..CaMKII?;and is this selective activation of the b1AR the mechanism for induction of adverse cardiac remodeling and heart failure post MI or pressure overload? We propose the hypothesis that a unique region of the carboxyl-terminal tail ..
  39. Redox regulation in aging and failing heart
    Junichi Sadoshima; Fiscal Year: 2013
    ..as Nox1 and p91phox (Nox2), has been extensively characterized, that of Nox4, an isoform of Nox expressed in the heart, is not well understood...
  40. Histone Deacetylase Inhibition: A Novel Approach to Cardioprotection
    Ting C Zhao; Fiscal Year: 2012
    ..However, the mechanism(s) by which HDAC inhibition protects the heart against injury remain unknown...
  41. ELEVATED CALCIUM AND MYOCARDIAL ISCHEMIC INJURY
    Charles Steenbergen; Fiscal Year: 2013
    ....
  42. AMP-activated protein kinase in the ischemic heart
    Lawrence H Young; Fiscal Year: 2012
    ..The overall aim of our research is to define the cellular and molecular mechanisms determining the response of the heart to myocardial ischemia, with the long-term goal to develop novel therapeutic approaches for patients with coronary ..
  43. Stem Cells For Myocardial Repair: A Large Bore Magnet Study
    Jianyi Zhang; Fiscal Year: 2012
    ..with postinfarction LV remodeling, the mechanisms that contribute to the transition from the compensated state to heart failure remain unclear, but may be related to progressive contractile dysfunction of the region of viable ..
  44. ROS, Inflammation, and Cardioprotection in Type 2 Diabetes
    Rakesh C Kukreja; Fiscal Year: 2013
    ..This disease constitutes a major independent risk factor for heart attack and myocardial cell death...
  45. EFFECT OF R1R2 OVER-EXPRESSION ON CARDIAC FUNCTION
    Michael Regnier; Fiscal Year: 2013
    ..of Ribonucleotide Reductase (R1R2), can be beneficial in potentiating cardiac function and treating heart failure...
  46. Cardioprotective Mechanisms of Glutathione S-transferase P
    DANIEL JOSEPH CONKLIN; Fiscal Year: 2012
    ..cardiac isoform, is an essential component of myocardial defense against oxidative stress and it protects the heart from acute oxidative damage during ischemia-reperfusion (I/R)...
  47. Impact of AMP-activated kinase on sex differences in hypertrophic cardiomyopathy
    John P Konhilas; Fiscal Year: 2013
    ..Humans with HCM caused by an autosomal dominant mutation (R403Q) in the predominant motor protein in the heart (1-myosin heavy chain) show a similar sex difference in cardiac disease progression...
  48. Tc-99m-Labled Cytokine Ligands and SPECT Inflammation Imaging of Ischemic Hearts
    Zhonglin Liu; Fiscal Year: 2012
    ..and reperfusion has been implicated as a crucial factor, which ultimately leads to ventricular remodeling, heart failure, and cardiovascular death...
  49. ACTIVATION OF XENOGENEIC ENDOTHELIUM TO RESIST INJURY
    Agustin P Dalmasso; Fiscal Year: 2010
    ..This will also provide knowledge for new treatments for vascular diseases, including ischemia and atherosclerosis. ..
  50. Modulating calcineurin signaling pathways in muscle
    Beverly A Rothermel; Fiscal Year: 2012
    Hypertrophic and ischemic heart disease has reached epidemic proportions both in this country and globally. As a result, there is urgent need for new and more effective therapies...
  51. In vivo Studies of Creatine Kinase Kinetics by 31P Magnetization Transfer MRS
    Adil Bashir; Fiscal Year: 2013
    ..S. despite improvements in prevention, detection, and treatment. Although the cause of heart failure is multi-factorial, there is increasing evidence that a mismatch in myocardial energy supply and demand ..
  52. Self-Sensing Physiologic Control of a Rotary Mag Lev LVAD
    JAMES FARLEY WALTON; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Heart failure is the number one cause of death in the United States and presents an increasing public burden of morbidity and mortality even as the mortality from coronary artery disease and ..
  53. Histamine Receptor Norepinephrine in Cardiac Dysfunction
    Roberto Levi; Fiscal Year: 2013
    ..these studies will elucidate new mechanisms for the control of renin and norepinephrine release in the heart. As the search for effective cardioprotective drugs continues unabated, our proposed studies will foster the ..
  54. Genetics of risk of chemotherapy-induced cardiotoxicity in cancer survivors
    Peter Demant; Fiscal Year: 2013
    ..However, in 50% of survivors they cause subclinical heart injury that can progress into incurable congestive heart failure...
  55. Viral Gene Expression to Therapeutic Levels in Models of Heart Failure
    Joseph E Rabinowitz; Fiscal Year: 2012
    ..of all deaths that occur in the United States each year, and the cost to the US economy, $394 billion (American Heart Association;2005), is almost 14 times greater than the NIH total annual budget (FY 2007 $28.4 billion)...
  56. Gender Effects on Remodeling of Lipid and Sarcomere Dynamics in Hypertrophy
    E Douglas Lewandowski; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Gender influences the pathogenesis of heart failure, despite no inherent differences in myocyte contractility...
  57. Molecular Mechanisms and Treatment of Primary Amyloid AL Cardiomyopathy
    Ronglih Liao; Fiscal Year: 2013
    ..The resulting amyloid AL cardiomyopathy is unique in that it is not responsive to standard heart failure regimens and is accompanied by greater than 50% mortality over 5 years, comparable to the most aggressive ..
  58. Hydrogen Peroxide and Flow-Induced Dilation of Human Coronary Microcirculation
    David D Gutterman; Fiscal Year: 2012
    ..Surprisingly the mitochondrial respiratory chain plays a necessary role in FMD in the human heart. The overall goal of this application is to examine the FMD signaling sequence from endothelium to smooth muscle ..
  59. Cardiac metabolism and heart failure
    Rong Tian; Fiscal Year: 2010
    ..increasingly recognized that altered cardiac energy metabolism is integral of the development and progression of heart failure, optimizing metabolism of the failing heart has proven to be a challenge as the mechanisms linking ..
  60. Calcium Handling in Cardiac Pathophysiology
    Evangelia G Kranias; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Heart failure (HF) continues to be a leading cause of morbidity and mortality...
  61. MYOCARDIAL PERFUSION IN THE HYPERTROPHIED HEART
    ROBERT JAMES BACHE; Fiscal Year: 2010
    ..studies supported by this grant have defined alterations of mitochondrial protein expression in the failing heart that are associated with abnormalities of myocardial energy metabolism, including loss of high energy phosphates (..
  62. Redox Modification of the Arrhythmic Substrate in Heart Failure
    RAIMOND LESTER WINSLOW; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Heart failure is a disease that is continually increasing in prevalence worldwide...
  63. Factors that Initiate Arrhythamias in Long QT Syndrome
    Guy Salama; Fiscal Year: 2006
    ..The specific aims are: 1) To test the hypothesis that autonomic activity to the heart modulates APDs, DOR and to determine the mechanisms underlying this neuromodulation by mapping simultaneously ..
  64. Gender-Differences in Cardiac Repolarization/Arrhythmias
    Guy Salama; Fiscal Year: 2005
    ..and their functional consequences on the electrical and intracellular free Ca2+ (Cai) handling properties of the heart. Clinical studies have shown that women have longer corrected QT intervals (QTc), a greater propensity to drug-..
  65. TOXICITY OF CARDIAC HYPOXIA AND REOXYGENATION
    JAMES KEHRER; Fiscal Year: 1991
    ..overall purpose of this project is to investigate some selected indices of oxidative stress in isolated-perfused heart tissue...
  66. CARDIOPROTECTIVE AGENTS IN ISCHEMIC MYOCYTES
    RICHARD HONKANEN; Fiscal Year: 2002
    ..phosphatases is the biochemical basis for the cardioprotective properties of fostriecin observed in ischemic heart tissue...
  67. Mitochondrial Protection Within Chronically Ischemic Myocardium
    Edward O McFalls; Fiscal Year: 2010
    ..of uncoupling protein (UCP)-2, as an adaptive process within mitochondria from hibernating and preconditioned heart tissue in the "Second Window of Protection" (SWOP), is protective against anoxia...
  68. Differential 02 Sensing in Right and Left hearts: Crosstalk with Ca-Signaling
    Shahrzad Movafagh; Fiscal Year: 2009
    ..leads to an array of events in the myocardium that include ischemic infarction, arrhythmia, cardiomyopathy, and heart failure...
  69. MITOCHONDRIA INCREASE OXIDATIVE INJURY IN AGING HEART
    EDWARD LESNEFSKY JR; Fiscal Year: 1999
    ..that a more rapid evolution of ischemic mitochondrial injury contributes to the increased damage in the aging heart. We propose that greater mitochondrial injury increases mitochondrial production of the very reactive and damaging ..
  70. MYOCARDIAL OXIDANT INJURY--KESHAN DISEASE AS A MODEL
    Raymond Burk; Fiscal Year: 1992
    ..This demonstrates that Se protects heart function against oxidant stress. Also Se deficiency led to increased taurine excretion in the urine by rats...
  71. REGIONAL MECHANICS OF LEFT VENTRICULAR ANEURYSM
    Julius Guccione; Fiscal Year: 1999
    ..2) provide the means to objectively evaluate modifications of conventional aneurysm repair and to develop new operations, possibly based on modifications of cardiomyoplasty or on "heart patches" produced from myocardial tissue cultures.
  72. Studies on a Novel RNA that Promotes Heart Development
    LARRY LEMANSKI; Fiscal Year: 2006
    ..lethal mutation in axolotls (salamanders), Ambystoma mexicanum, is an intriguing model for studying early heart development, because homozygous embryos (c/c) form hearts that are deficient in tropomyosin, lack organized ..
  73. Heat Shock Proteins, Nitric Oxide and Oxygen Consumption in the Heart
    Govindasamy Ilangovan; Fiscal Year: 2009
    ..myocardial infarction, IPC is known to induce nitric oxide (NO), which can mediate various processes in the heart to minimize ischemic injury...
  74. MYOSIN CROSSBRIDGE FUNCTION IN HUMAN HEART FAILURE
    Norman Alpert; Fiscal Year: 1999
    In congestive heart failure due to mitral regurgitation (MR) and idiopathic dilated cardiomyopathy (IDCM) the dilated ventricle undergoes dramatic decreases in the velocity of myocardial shortening and power output...
  75. Myocardial Ischemia-Reperfusion and Protein Phosphatase 2a
    Polly A Hofmann; Fiscal Year: 2010
    ..We believe this is of benefit to the heart. Support of a beneficial effect comes from our studies in which we show that inducing demethylation of PP2aC prior ..
  76. SUBENDOCARDIAL O2 SUPPLY AND DEMAND IN AORTIC STENOSIS
    Peter Scholz; Fiscal Year: 1992
    ..Long- term, we wish to study ways to improve imbalances in regional 02 supply/consumption and inefficiencies using beta blockade...
  77. Beta-adrenergic Response in Cardiac Hypertrophy/Failure
    Meredith Bond; Fiscal Year: 2004
    Alterations in the signal transduction pathways which regulate Ca2+ dependent force in the heart contribute to the impaired contractile function in heart failure...