vascular endothelium


Summary: Single pavement layer of cells which line the luminal surface of the entire vascular system and regulate the transport of macromolecules and blood components from interstitium to lumen; this function has been most intensively studied in the blood capillaries.

Top Publications

  1. ncbi Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: a report of the International Brachial Artery Reactivity Task Force
    Mary C Corretti
    Division of Cardiology, University of Maryland School of Medicine, Baltimore, Maryland 21205 1595, USA
    J Am Coll Cardiol 39:257-65. 2002
  2. ncbi Circulating endothelial progenitor cells, vascular function, and cardiovascular risk
    Jonathan M Hill
    Cardiovascular Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1622, USA
    N Engl J Med 348:593-600. 2003
  3. ncbi Number and migratory activity of circulating endothelial progenitor cells inversely correlate with risk factors for coronary artery disease
    M Vasa
    Division of Molecular Cardiology, Department of Internal Medicine IV, University of Frankfurt, Germany
    Circ Res 89:E1-7. 2001
  4. ncbi Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation
    S Dimmeler
    Molecular Cardiology, Department of Internal Medicine IV, University of Frankfurt, Germany
    Nature 399:601-5. 1999
  5. ncbi The biology of VEGF and its receptors
    Napoleone Ferrara
    Department of Molecular Oncology, Genentech, Inc, 1 DNA Way, South San Francisco, California 94080, USA
    Nat Med 9:669-76. 2003
  6. ncbi Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis
    C Suri
    Regeneron Pharmaceuticals, Inc, Tarrytown, New York 10591, USA
    Cell 87:1171-80. 1996
  7. ncbi Mechanisms of angiogenesis and arteriogenesis
    P Carmeliet
    The Center for Transgene Technology and Gene Therapy Flanders Interuniversity Institute for Biotechnology KU Leuven, Leuven, B 3000, Belgium
    Nat Med 6:389-95. 2000
  8. pmc Size-selective loosening of the blood-brain barrier in claudin-5-deficient mice
    Takehiro Nitta
    Department of Cell Biology, Faculty of Medicine, Kyoto University, Japan
    J Cell Biol 161:653-60. 2003
  9. ncbi Mechanisms of increased vascular superoxide production in human diabetes mellitus: role of NAD(P)H oxidase and endothelial nitric oxide synthase
    Tomasz J Guzik
    Department of Cardiovascular Medicine, University of Oxford, Oxford, UK
    Circulation 105:1656-62. 2002
  10. ncbi Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis
    Mats Hellstrom
    AngioGenetics Sweden AB, Scheeles vag 2, SE 171 77 Stockholm, Sweden
    Nature 445:776-80. 2007

Detail Information

Publications248 found, 100 shown here

  1. ncbi Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: a report of the International Brachial Artery Reactivity Task Force
    Mary C Corretti
    Division of Cardiology, University of Maryland School of Medicine, Baltimore, Maryland 21205 1595, USA
    J Am Coll Cardiol 39:257-65. 2002
  2. ncbi Circulating endothelial progenitor cells, vascular function, and cardiovascular risk
    Jonathan M Hill
    Cardiovascular Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1622, USA
    N Engl J Med 348:593-600. 2003
  3. ncbi Number and migratory activity of circulating endothelial progenitor cells inversely correlate with risk factors for coronary artery disease
    M Vasa
    Division of Molecular Cardiology, Department of Internal Medicine IV, University of Frankfurt, Germany
    Circ Res 89:E1-7. 2001
    ..The full text of this article is available at
  4. ncbi Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation
    S Dimmeler
    Molecular Cardiology, Department of Internal Medicine IV, University of Frankfurt, Germany
    Nature 399:601-5. 1999
    ..Thus, phosphorylation of eNOS by Akt represents a novel Ca2+-independent regulatory mechanism for activation of eNOS...
  5. ncbi The biology of VEGF and its receptors
    Napoleone Ferrara
    Department of Molecular Oncology, Genentech, Inc, 1 DNA Way, South San Francisco, California 94080, USA
    Nat Med 9:669-76. 2003
    ..VEGF inhibition is also being tested as a strategy for the prevention of angiogenesis, vascular leakage and visual loss in age-related macular degeneration...
  6. ncbi Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis
    C Suri
    Regeneron Pharmaceuticals, Inc, Tarrytown, New York 10591, USA
    Cell 87:1171-80. 1996
    ..Angiopoietin-1 seems to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme...
  7. ncbi Mechanisms of angiogenesis and arteriogenesis
    P Carmeliet
    The Center for Transgene Technology and Gene Therapy Flanders Interuniversity Institute for Biotechnology KU Leuven, Leuven, B 3000, Belgium
    Nat Med 6:389-95. 2000
  8. pmc Size-selective loosening of the blood-brain barrier in claudin-5-deficient mice
    Takehiro Nitta
    Department of Cell Biology, Faculty of Medicine, Kyoto University, Japan
    J Cell Biol 161:653-60. 2003
    ..e., the size-selective loosening of the BBB) not only provides new insight into the basic molecular physiology of BBB but also opens a new way to deliver potential drugs across the BBB into the central nervous system...
  9. ncbi Mechanisms of increased vascular superoxide production in human diabetes mellitus: role of NAD(P)H oxidase and endothelial nitric oxide synthase
    Tomasz J Guzik
    Department of Cardiovascular Medicine, University of Oxford, Oxford, UK
    Circulation 105:1656-62. 2002
    ..We characterized the sources and mechanisms underlying vascular superoxide production in human blood vessels from diabetic patients with coronary artery disease compared with nondiabetic patients...
  10. ncbi Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis
    Mats Hellstrom
    AngioGenetics Sweden AB, Scheeles vag 2, SE 171 77 Stockholm, Sweden
    Nature 445:776-80. 2007
  11. ncbi The clinical implications of endothelial dysfunction
    Michael E Widlansky
    Evans Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA
    J Am Coll Cardiol 42:1149-60. 2003
    ..This article will review this growing literature in an effort to evaluate the current clinical utility of endothelial dysfunction...
  12. pmc Regulation of endothelium-derived nitric oxide production by the protein kinase Akt
    D Fulton
    Department of Pharmacology, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, Connecticut 06536, USA
    Nature 399:597-601. 1999
    ..Thus, eNOS is a newly described Akt substrate linking signal transduction by Akt to the release of the gaseous second messenger NO...
  13. ncbi Molecular regulation of vessel maturation
    Rakesh K Jain
    E L Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, 100 Blossom Street, Boston, Massachusetts 02114, USA
    Nat Med 9:685-93. 2003
    ..Normalization of the abnormal vasculature can facilitate drug delivery to tumors and formation of a mature vasculature can help realize the promise of therapeutic angiogenesis and tissue engineering...
  14. ncbi Therapeutic stem and progenitor cell transplantation for organ vascularization and regeneration
    Shahin Rafii
    Department of Hematology Oncology and Genetic Medicine, Cornell University Medical College, New York, New York, 10021 USA
    Nat Med 9:702-12. 2003
    ..In this review, we discuss the clinical potential of vascular progenitor and stem cells to restore long-lasting organ vascularization and function...
  15. ncbi Endothelial function and dysfunction. Part I: Methodological issues for assessment in the different vascular beds: a statement by the Working Group on Endothelin and Endothelial Factors of the European Society of Hypertension
    John Deanfield
    Vascular Physiology Unit, Institute of Child Health and Great Ormond Street Hospital NHS Trust, London, UK
    J Hypertens 23:7-17. 2005
    ..Thus, the most relevant methodological issues in the research on endothelial function and dysfunction are summarized in this paper...
  16. ncbi Leakage-resistant blood vessels in mice transgenically overexpressing angiopoietin-1
    G Thurston
    Department of Anatomy and Cardiovascular Research Institute, University of California, San Francisco, CA 94143 0452, USA
    Science 286:2511-4. 1999
    ..Ang1 therefore may be useful for reducing microvascular leakage in diseases in which the leakage results from chronic inflammation or elevated VEGF and, in combination with VEGF, for promoting growth of nonleaky vessels...
  17. ncbi Vascular endothelium expresses 3-mercaptopyruvate sulfurtransferase and produces hydrogen sulfide
    Norihiro Shibuya
    National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    J Biochem 146:623-6. 2009 that 3-mercaptopyruvate sulfurtransferase (3MST) and cysteine aminotransferase (CAT) are localized to vascular endothelium in the thoracic aorta and produce H(2)S. Both 3MST and CAT were localized to endothelium...
  18. ncbi Endothelial dysfunction, oxidative stress, and risk of cardiovascular events in patients with coronary artery disease
    T Heitzer
    Universitatsklinikum Hamburg Eppendorf, Klinik und Poliklinik für Innere Medizin, Abteilung Kardiologie, Hamburg, Germany
    Circulation 104:2673-8. 2001
    ..This study was designed to determine whether endothelial dysfunction and vascular oxidative stress have prognostic impact on cardiovascular event rates in patients with coronary artery disease...
  19. ncbi Superoxide production and expression of nox family proteins in human atherosclerosis
    Dan Sorescu
    Department of Medicine, Emory University, Atlanta, GA 30322, USA
    Circulation 105:1429-35. 2002
  20. pmc Autocrine VEGF signaling is required for vascular homeostasis
    Sunyoung Lee
    Department of Molecular, Cellular and Developmental Biology, Jonsson Comprehensive Cancer Center and Molecular Biology Institute, UCLA, Los Angeles, CA 90095, USA
    Cell 130:691-703. 2007
    ..These results reveal a cell-autonomous VEGF signaling pathway that holds significance for vascular homeostasis but is dispensable for the angiogenic cascade...
  21. ncbi Vascular complications in diabetes mellitus: the role of endothelial dysfunction
    Casper G Schalkwijk
    Department of Internal Medicine, Academic Hospital Maastricht, The Netherlands
    Clin Sci (Lond) 109:143-59. 2005
    ..Dysfunction of the vascular endothelium is regarded as an important factor in the pathogenesis of diabetic micro- and macro-angiopathy...
  22. ncbi Endothelial function and dysfunction: testing and clinical relevance
    John E Deanfield
    Vascular Physiology Unit, UCL Institute of Child Health, London, UK
    Circulation 115:1285-95. 2007
  23. pmc Endothelial claudin: claudin-5/TMVCF constitutes tight junction strands in endothelial cells
    K Morita
    Department of Cell Biology, Faculty of Medicine, Kyoto University, Kyoto 606 8501, Japan
    J Cell Biol 147:185-94. 1999
    ..e., the extracellular face-associated TJs. These findings indicated that claudin-5/TMVCF is an endothelial cell-specific component of TJ strands...
  24. ncbi Reciprocal relationships between insulin resistance and endothelial dysfunction: molecular and pathophysiological mechanisms
    Jeong A Kim
    Diabetes Unit, National Center for Complementary and Alternative Medicine, National Institutes of Health, Bethesda, MD 20892 1632, USA
    Circulation 113:1888-904. 2006
    ..In the present review, we discuss pathophysiological mechanisms, including inflammatory processes, that couple endothelial dysfunction with insulin resistance and emphasize important therapeutic implications...
  25. ncbi Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells
    N Ferrara
    Department of Pharmacological Sciences, Genentech Inc, South San Francisco, CA 94080
    Biochem Biophys Res Commun 161:851-8. 1989
    ..Microsequencing reveals a unique N-terminal amino acid sequence. On the basis of its apparent target cell selectivity, we propose to name this factor vascular endothelial growth factor (VEGF)...
  26. pmc Regeneration of ischemic cardiac muscle and vascular endothelium by adult stem cells
    K A Jackson
    Center for Cell and Gene Therapy and Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA
    J Clin Invest 107:1395-402. 2001
    ..3%, primarily in small vessels adjacent to the infarct. Our results demonstrate the cardiomyogenic potential of hematopoietic stem cells and suggest a therapeutic strategy that eventually could benefit patients with myocardial infarction...
  27. ncbi Endothelial dysfunction: a marker of atherosclerotic risk
    Piero O Bonetti
    Center for Coronary Physiology and Imaging, Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Arterioscler Thromb Vasc Biol 23:168-75. 2003
    ..In line with this hypothesis, dysfunction of either the coronary or peripheral vascular endothelium was shown to constitute an independent predictor of cardiovascular events, providing valuable prognostic ..
  28. pmc Plasma sodium stiffens vascular endothelium and reduces nitric oxide release
    Hans Oberleithner
    Institute of Physiology II and Department of Internal Medicine D, University of Munster, 48149 Munster, Germany
    Proc Natl Acad Sci U S A 104:16281-6. 2007
    ..The results suggest that changes in plasma sodium concentration per se may affect endothelial function and thus control vascular tone...
  29. ncbi Mechanisms underlying endothelial dysfunction in diabetes mellitus
    U Hink
    Universitatskrankenhaus Eppendorf, Germany
    Circ Res 88:E14-22. 2001
    ..The full text of this article is available at
  30. ncbi A self-fulfilling prophecy: C-reactive protein attenuates nitric oxide production and inhibits angiogenesis
    Subodh Verma
    Division of Cardiac Surgery, Toronto General Hospital, University of Toronto, Toronto, Canada
    Circulation 106:913-9. 2002
  31. ncbi Regular physical activity improves endothelial function in patients with coronary artery disease by increasing phosphorylation of endothelial nitric oxide synthase
    R Hambrecht
    Heart Center, Department of Cardiology, University of Leipzig, Germany
    Circulation 107:3152-8. 2003
  32. ncbi SDF-1 involvement in endothelial phenotype and ischemia-induced recruitment of bone marrow progenitor cells
    Elena De Falco
    Laboratorio di Patologia Vascolare, Istituto Dermopatico dell Immacolata Istituto di Ricovero e Cura a Carattere Scientifico, Rome, Italy
    Blood 104:3472-82. 2004
    ..Our findings unravel a function for SDF-1 in increase of EPC number and formation of vascular structures by bone marrow progenitor cells...
  33. ncbi Tie2-Cre transgenic mice: a new model for endothelial cell-lineage analysis in vivo
    Y Y Kisanuki
    Department of Molecular Genetics, Howard Hughes Medical Institute, Dallas, Texas, 75390 9050, USA
    Dev Biol 230:230-42. 2001
    ..Tie2-Cre transgenic mice are a new genetic tool for the analyses of endothelial cell-lineage and endothelial cell-specific gene targeting...
  34. pmc Rap1 translates chemokine signals to integrin activation, cell polarization, and motility across vascular endothelium under flow
    Mika Shimonaka
    Bayer Chair, Dept of Molecular Immunology and Allergy, Graduate School of Medicine, Kyoto University, Yoshida Konoe, Sakyo ku, Kyoto 606 8501, Japan
    J Cell Biol 161:417-27. 2003
    ..Spa1 effectively suppressed this polarization after SLC treatment. This unique characteristic of Rap1 may control chemokine-induced lymphocyte extravasation...
  35. ncbi Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning
    S Davis
    Regeneron Pharmaceuticals, Inc, Tarrytown, New York 10591, USA
    Cell 87:1161-9. 1996
    ..However, its expression in close proximity with developing blood vessels implicates Angiopoietin-1 in endothelial developmental processes...
  36. ncbi Noninvasive identification of patients with early coronary atherosclerosis by assessment of digital reactive hyperemia
    Piero O Bonetti
    Center for Coronary Physiology and Imaging, Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, USA
    J Am Coll Cardiol 44:2137-41. 2004
    ..We investigated the value of reactive hyperemia peripheral arterial tonometry (RH-PAT) as a noninvasive tool to identify individuals with coronary microvascular endothelial dysfunction...
  37. pmc Lack of pericytes leads to endothelial hyperplasia and abnormal vascular morphogenesis
    M Hellstrom
    Department of Medical Biochemistry, Goteborg University, SE 405 30 Goteborg, Sweden
    J Cell Biol 153:543-53. 2001
  38. ncbi Endothelial progenitor cells: mobilization, differentiation, and homing
    Mihail Hristov
    Institut für Prophylaxe und Epidemiologie der Kreislaufkrankheiten, Ludwig Maximilians Universitat, Pettenkoferstr 9, 80336 Munchen, Germany
    Arterioscler Thromb Vasc Biol 23:1185-9. 2003
    ..Thus, future studies will help to explore areas of potential basic research and clinical application of EPCs...
  39. pmc Spatially restricted patterning cues provided by heparin-binding VEGF-A control blood vessel branching morphogenesis
    Christiana Ruhrberg
    Endothelial Cell Biology Laboratory, Cancer Research UK London Research Institute, London WC2A 3PX, United Kingdom
    Genes Dev 16:2684-98. 2002
    ..We conclude that differential VEGF-A isoform localization in the extracellular space provides a control point for regulating vascular branching pattern...
  40. ncbi Gene transfer of stromal cell-derived factor-1alpha enhances ischemic vasculogenesis and angiogenesis via vascular endothelial growth factor/endothelial nitric oxide synthase-related pathway: next-generation chemokine therapy for therapeutic neovasculariz
    Ken ichi Hiasa
    Department of Cardiovascular Medicine, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan
    Circulation 109:2454-61. 2004
    ..We therefore hypothesized that SDF-1alpha gene transfer would induce therapeutic neovascularization in vivo by functioning as a chemokine of EPC...
  41. pmc Transplanted cord blood-derived endothelial precursor cells augment postnatal neovascularization
    T Murohara
    The Cardiovascular Research Institute, Department of Internal Medicine III, Kurume University School of Medicine, Kurume, Japan
    J Clin Invest 105:1527-36. 2000
    ..In conclusion, umbilical cord blood is a valuable source of EPCs, and transplantation of cord blood-derived EPCs represents a promising strategy for modulating postnatal neovascularization...
  42. ncbi Interactions of peroxynitrite, tetrahydrobiopterin, ascorbic acid, and thiols: implications for uncoupling endothelial nitric-oxide synthase
    Nermin Kuzkaya
    Division of Cardiology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 278:22546-54. 2003
    ..We confirmed that ONOO- uncouples eNOS by oxidation of tetrahydrobiopterin and that ascorbate does not fully protect BH4 from oxidation but recycles BH3. radical back to BH4...
  43. ncbi Effects of diet and exercise on obesity-related vascular dysfunction in children
    Kam S Woo
    Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong
    Circulation 109:1981-6. 2004
    ..Obesity in children is independently associated with arterial endothelial dysfunction and wall thickening, key early events in atherogenesis that precede plaque formation...
  44. ncbi Mesenchymal stem cells differentiate into an endothelial phenotype, enhance vascular density, and improve heart function in a canine chronic ischemia model
    Guilherme V Silva
    Texas Heart Institute at St Luke s Episcopal Hospital, Houston, Tex 77030, USA
    Circulation 111:150-6. 2005
    ..Bone marrow-derived stem cells are under investigation as a treatment for ischemic heart disease. Mesenchymal stem cells (MSCs) have been used preferentially in the acute ischemia model; data in the chronic ischemia model are lacking...
  45. ncbi Enhanced external counterpulsation improves endothelial function in patients with symptomatic coronary artery disease
    Piero O Bonetti
    Center for Coronary Physiology and Imaging and the Cardiac Catheterization Laboratory, Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic and Foundation, 200 First Street SW, Rochester, MN 55905, USA
    J Am Coll Cardiol 41:1761-8. 2003
    ..The goal of this study was to examine the effect of enhanced external counterpulsation (EECP) on endothelial function...
  46. ncbi Hemodynamic shear stress and its role in atherosclerosis
    A M Malek
    Neurosurgery, Brigham and Women s Hospital and Children s Hospital, Boston, Mass 02115, USA
    JAMA 282:2035-42. 1999
  47. ncbi Molecular and biological properties of vascular endothelial growth factor
    N Ferrara
    Department of Cardiovascular Research, Genentech Inc, South San Francisco, CA 94080, USA
    J Mol Med (Berl) 77:527-43. 1999
    ..Currently, both therapeutic angiogenesis using recombinant VEGF or VEGF gene transfer and inhibition of VEGF-mediated pathological angiogenesis are being pursued...
  48. ncbi Defective angiogenesis in mice lacking endoglin
    D Y Li
    Program in Human Molecular Biology and Genetics, Department of Human Genetics, Howard Hughes Medical Institute, University of Utah, Salt Lake City, UT 84112 5330, USA
    Science 284:1534-7. 1999
    ..Loss of endoglin caused poor vascular smooth muscle development and arrested endothelial remodeling. These results demonstrate that endoglin is essential for angiogenesis and suggest a pathogenic mechanism for HHT1...
  49. pmc Potassium softens vascular endothelium and increases nitric oxide release
    H Oberleithner
    Institute of Physiology II, University of Munster, D 48149 Munster, Germany
    Proc Natl Acad Sci U S A 106:2829-34. 2009
    ..Such a mechanism would control endothelial deformability and nitric oxide release, and thus influence systemic blood pressure...
  50. ncbi Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis
    P Carmeliet
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, Leuven, Belgium
    Cell 98:147-57. 1999
    ..Thus, VE-cadherin/ beta-catenin signaling controls endothelial survival...
  51. pmc Origin of endothelial progenitors in human postnatal bone marrow
    Morayma Reyes
    Stem Cell Institute, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    J Clin Invest 109:337-46. 2002
    ..Because MAPCs can be expanded in culture without obvious senescence for more than 80 population doublings, they may be an important source of endothelial cells for cellular pro- or anti-angiogenic therapies...
  52. pmc Inflammation, oxidative stress, and repair capacity of the vascular endothelium in obstructive sleep apnea
    Sanja Jelic
    Columbia University College of Physicians and Surgeons, Division of Pulmonary, Allergy, and Critical Care Medicine, PH8 Center, Room 840, 630 W 168th St, New York, NY 10032, USA
    Circulation 117:2270-8. 2008
    ..We investigated directly whether dysfunction and inflammation occur in vivo in the vascular endothelium of patients with OSA...
  53. ncbi Impaired recruitment of bone-marrow-derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth
    D Lyden
    Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, New York, New York, USA
    Nat Med 7:1194-201. 2001
    ..These data demonstrate that recruitment of VEGF-responsive BM-derived precursors is necessary and sufficient for tumor angiogenesis and suggest new clinical strategies to block tumor growth...
  54. ncbi Regulation of TNF-alpha-induced reorganization of the actin cytoskeleton and cell-cell junctions by Rho, Rac, and Cdc42 in human endothelial cells
    B Wojciak-Stothard
    Ludwig Institute for Cancer Research, London, United Kingdom
    J Cell Physiol 176:150-65. 1998
    ..Our data suggest that Cdc42, Rac, and Rho are activated in a hierarchical cascade following stimulation with TNF-alpha leading to actomyosin-mediated cell retraction and formation of intercellular gaps...
  55. ncbi Differentiation of monocytes into dendritic cells in a model of transendothelial trafficking
    G J Randolph
    Department of Pathology, Cornell University Medical College, 1300 York Avenue, Room C 420, New York, NY 10021, USA
    Science 282:480-3. 1998
    ..Monocytes that remained in the subendothelial matrix became macrophages. Therefore, monocytes have two potential fates associated with distinct patterns of migration...
  56. ncbi Lysosome-associated membrane proteins h-LAMP1 (CD107a) and h-LAMP2 (CD107b) are activation-dependent cell surface glycoproteins in human peripheral blood mononuclear cells which mediate cell adhesion to vascular endothelium
    K Kannan
    Department of Medicine and Center for Excellence in Cancer Research, Louisana State University Medical Center, Shreveport, Louisiana 71130 3932, USA
    Cell Immunol 171:10-9. 1996
    ..In the present study, the role of lamp2 (CD107b) in lymphocyte adhesion to vascular endothelium and the factors which influence in vitro cell surface expression of both lamp1 (CD107a) and lamp2 (CD107b) ..
  57. pmc Involvement of Foxo transcription factors in angiogenesis and postnatal neovascularization
    Michael Potente
    Molecular Cardiology, Department of Internal Medicine III, University of Frankfurt, Frankfurt am Main, Germany
    J Clin Invest 115:2382-92. 2005
    ..In vivo, Foxo3a deficiency increased eNOS expression and enhanced postnatal vessel formation and maturation. Thus, our data suggest an important role for Foxo transcription factors in the regulation of vessel formation in the adult...
  58. ncbi VEGF is required for growth and survival in neonatal mice
    H P Gerber
    Departments of Cardiovascular Research and Pathology, Genentech, Inc, South San Francisco, CA 94080, USA
    Development 126:1149-59. 1999
    ..Thus, VEGF is essential for growth and survival in early postnatal life. However, in the fully developed animal, VEGF is likely to be involved primarily in active angiogenesis processes such as corpus luteum development...
  59. ncbi Occludin as a possible determinant of tight junction permeability in endothelial cells
    T Hirase
    Eisai London Research Laboratories Ltd, University College London, UK
    J Cell Sci 110:1603-13. 1997
    ..Our data indicate that regulation of occludin expression may be a crucial determinant of the tight junction permeability properties of endothelial cells in different tissues...
  60. ncbi Reactive oxygen species in the vasculature: molecular and cellular mechanisms
    Yoshihiro Taniyama
    Department of Medicine, Division of Cardiology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Hypertension 42:1075-81. 2003
    ..ROS, by regulating vascular cell function, can play a central role in normal vascular physiology, and can contribute substantially to the development of vascular disease...
  61. pmc Endoglin promotes endothelial cell proliferation and TGF-beta/ALK1 signal transduction
    Franck Lebrin
    Division of Cellular Biochemistry, The Netherlands Cancer Institute, Plesmanlaan, Amsterdam, The Netherlands
    EMBO J 23:4018-28. 2004
    ..Our results indicate a pivotal role for endoglin in the balance of ALK1 and ALK5 signalling to regulate endothelial cell proliferation...
  62. ncbi Lack of an endothelial store-operated Ca2+ current impairs agonist-dependent vasorelaxation in TRP4-/- mice
    M Freichel
    Institut fur Pharmakologie und Toxikologie, Universitat des Saarlandes, D 66421 Homburg, Germany
    Nat Cell Biol 3:121-7. 2001
    ..Here we describe a store-operated Ca2+ current in vascular endothelium and show that endothelial cells of mice deficient in TRP4 (also known as CCE1) lack this current...
  63. ncbi Endothelial function in obstructive sleep apnea and response to treatment
    Mary S M Ip
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong SAR, China
    Am J Respir Crit Care Med 169:348-53. 2004
    ..02) and were similar to baseline values. Our findings demonstrated that men with moderate/severe OSA have endothelial dysfunction and treatment with nCPAP could reverse the dysfunction; the effect, however, was dependent on ongoing use...
  64. ncbi Angiogenic and angiostatic factors in the molecular control of angiogenesis
    J H W Distler
    WHO Collaborating Center for Molecular Biology and Novel Therapeutic Strategies for Rheumatic Diseases, University Hospital, Zurich, Switzerland
    Q J Nucl Med 47:149-61. 2003
  65. ncbi Fundamentals of endothelial function for the clinical cardiologist
    Subodh Verma
    Division of Cardiac Surgery, University of Toronto, University of Calgary, Canada
    Circulation 105:546-9. 2002
  66. ncbi Endothelial dysfunction and increased arterial intima-media thickness in children with type 1 diabetes
    Mikko J Jarvisalo
    Department of Clinical Physiology, University of Turku, Turku, Finland
    Circulation 109:1750-5. 2004
  67. ncbi Endothelial progenitor cells: characterization and role in vascular biology
    Carmen Urbich
    Molecular Cardiology, Department of Internal Medicine IV, University of Frankfurt, Frankfurt, Germany
    Circ Res 95:343-53. 2004
    ..This review summarizes the mechanisms regulating endothelial progenitor cell-mediated neovascularization and reendothelialization...
  68. ncbi Notch signalling limits angiogenic cell behaviour in developing zebrafish arteries
    Arndt F Siekmann
    Program in Gene Function and Expression, University of Massachusetts Medical School, Lazare Research Building, 364 Plantation Street, Worcester, Massachusetts 01605, USA
    Nature 445:781-4. 2007
    ..Together, these studies indicate that proper specification of cell identity, position and behaviour in a developing blood-vessel sprout is required for normal angiogenesis, and implicate the Notch signalling pathway in this process...
  69. ncbi Adiponectin, an adipocyte-derived plasma protein, inhibits endothelial NF-kappaB signaling through a cAMP-dependent pathway
    N Ouchi
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Osaka, Japan
    Circulation 102:1296-301. 2000
    ..However, the intracellular signal by which adiponectin suppressed adhesion molecule expression was not elucidated. The present study investigated the mechanism of modulation for endothelial function by adiponectin...
  70. ncbi Role of oxidative modifications in atherosclerosis
    Roland Stocker
    Centre for Vascular Research, University of New South Wales, Sydney, New South Wales, Australia
    Physiol Rev 84:1381-478. 2004
    ..To address this issue, we have proposed an "oxidative response to inflammation" model as a means of reconciling the response-to-injury and oxidative modification hypotheses of atherosclerosis...
  71. ncbi Endothelial cell-to-cell junctions: molecular organization and role in vascular homeostasis
    Gianfranco Bazzoni
    Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, I 20157 Milan, Italy
    Physiol Rev 84:869-901. 2004
    ..Finally, we analyze in vivo studies and highlight information that specifically relates to the role of junctions in vascular endothelial cells...
  72. ncbi Pericyte loss and microaneurysm formation in PDGF-B-deficient mice
    P Lindahl
    Department of Medical Biochemistry, University of Goteborg, Medicinaregatan 9A, S 413 90 Göteborg, Sweden
    Science 277:242-5. 1997
    ..Pericytes may contribute to the mechanical stability of the capillary wall. Comparisons made between PDGF null mouse phenotypes suggest a general role for PDGFs in the development of myofibroblasts...
  73. ncbi sonic hedgehog and vascular endothelial growth factor act upstream of the Notch pathway during arterial endothelial differentiation
    Nathan D Lawson
    Laboratory of Molecular Genetics, NICHD, NIH, Bethesda, MD 20892, USA
    Dev Cell 3:127-36. 2002
    ..These studies reveal a complex signaling cascade responsible for establishing arterial cell fate and suggest differential effects of Vegf on developing endothelial cells...
  74. ncbi The notch ligands Dll4 and Jagged1 have opposing effects on angiogenesis
    Rui Benedito
    Cancer Research UK London Research Institute, Vascular Development Laboratory, London, UK
    Cell 137:1124-35. 2009
  75. pmc Bone marrow-derived circulating endothelial precursors do not contribute to vascular endothelium and are not needed for tumor growth
    Susanna Purhonen
    Academy of Finland Center of Excellence in Cancer Biology and Molecular Cancer Biology Laboratory, Molecular Cancer Biology Research Program, University of Helsinki, P O Box 63, 00014, Helsinki, Finland
    Proc Natl Acad Sci U S A 105:6620-5. 2008
    ..Our results show that no BM-derived VEGFR-2+ or other EC precursors contribute to vascular endothelium and that cancer growth does not require BM-derived endothelial progenitors...
  76. pmc HMG-CoA reductase inhibitors (statins) increase endothelial progenitor cells via the PI 3-kinase/Akt pathway
    S Dimmeler
    Division of Molecular Cardiology, Department of Medicine IV, University of Frankfurt, Frankfurt, Germany
    J Clin Invest 108:391-7. 2001
  77. ncbi CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells
    V Henn
    Molecular Immunology, Robert Koch Institute, Berlin, Germany
    Nature 391:591-4. 1998
    ..Our results indicate that platelets are not only involved in haemostasis but that they also directly initiate an inflammatory response of the vessel wall...
  78. ncbi The role of the vascular endothelium in arenavirus haemorrhagic fevers
    Stefan Kunz
    Institute of Microbiology, University Hospital Center and University of Lausanne, Lausanne, Switzerland
    Thromb Haemost 102:1024-9. 2009
    ..The functional alteration of the vascular endothelium that precede shock and death in fatal Lassa fever may be due to more subtle direct or indirect effects of ..
  79. ncbi Cell surface tumor endothelial markers are conserved in mice and humans
    E B Carson-Walter
    The Howard Hughes Medical Institute, Baltimore, Maryland 21231, USA
    Cancer Res 61:6649-55. 2001
    ..The coordinate expression of TEM1, TEM5, and TEM8 on tumor endothelium in humans and mice makes these genes attractive targets for the development of antiangiogenic therapies...
  80. ncbi Endothelial dysfunction: a multifaceted disorder (The Wiggers Award Lecture)
    Michel Feletou
    Department of Angiology, Institut de Recherches Servier, Suresnes, France
    Am J Physiol Heart Circ Physiol 291:H985-1002. 2006
    ..Therapeutic interventions do not necessarily restore a proper endothelial function and, when they do, may improve only part of these variables...
  81. ncbi Endothelial function: cardiac events
    Amir Lerman
    Division of Cardiovascular Disease and Department of Internal Medicine, Mayo College of Medicine, 200 First St SW, Rochester, MN 55902, USA
    Circulation 111:363-8. 2005
  82. ncbi The involvement of endothelial progenitor cells in tumor angiogenesis
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Bari I 70124, Italy
    J Cell Mol Med 8:294-300. 2004
    ..This review article will summarize the literature data concerning this new role played by EPCs in tumor angiogenesis...
  83. ncbi Suppression of Fas-FasL-induced endothelial cell apoptosis prevents diabetic blood-retinal barrier breakdown in a model of streptozotocin-induced diabetes
    Antonia M Joussen
    Retina Research Institute, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts 02114, USA
    FASEB J 17:76-8. 2003
    ..These data imply that the targeting of the Fas-FasL pathway may prove beneficial in the treatment of diabetic retinopathy...
  84. ncbi The vascular endothelium as a target of cadmium toxicity
    Walter C Prozialeck
    Department of Pharmacology, Midwestern University, 555 31st Street, Downers Grove, IL 60515, United States
    Life Sci 79:1493-506. 2006
    ..A growing volume of evidence indicates that the vascular endothelium may be one of the primary targets of Cd toxicity in vivo...
  85. pmc Blood-brain barrier invasion by group B Streptococcus depends upon proper cell-surface anchoring of lipoteichoic acid
    Kelly S Doran
    Department of Pediatrics, Division of Infectious Diseases, UCSD School of Medicine, La Jolla, California 92093, USA
    J Clin Invest 115:2499-507. 2005
    ..Our data suggest that LTA expression on the GBS surface plays a role in bacterial interaction with BBB endothelium and the pathogenesis of neonatal meningitis...
  86. pmc Sphingosine kinase mediates vascular endothelial growth factor-induced activation of ras and mitogen-activated protein kinases
    Xiaodong Shu
    Department of Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center, Keck School of Medicine at the University of Southern California, Los Angeles, California 90089, USA
    Mol Cell Biol 22:7758-68. 2002
    ..These data highlight a novel mechanism by which SPK mediates signaling from PKC to Ras in a manner independent of Ras-guanine nucleotide exchange factor...
  87. ncbi Myosin light chain kinase in endothelium: molecular cloning and regulation
    J G Garcia
    Department of Medicine, Indiana University School of Medicine, and Richard Roudebush Veterans Administration Center, Indianapolis, USA
    Am J Respir Cell Mol Biol 16:489-94. 1997
    ..5-fold increase) and reduced kinase activity in MLCK immunoprecipitates (4-fold decrease). These data suggest potentially novel mechanisms of endothelial cell contraction and barrier regulation...
  88. ncbi Vascular endothelial dysfunction: does tetrahydrobiopterin play a role?
    Z S Katusic
    Department of Anesthesiology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Am J Physiol Heart Circ Physiol 281:H981-6. 2001
    ..In this review, the potential role of tetrahydrobiopterin in the pathogenesis of vascular endothelial dysfunction and mechanisms underlying beneficial vascular effects of tetrahydrobiopterin will be discussed...
  89. ncbi Ion channels and their functional role in vascular endothelium
    B Nilius
    Department of Physiology, KU Leuven, Campus Gasthuisberg, Leuven, Belgium
    Physiol Rev 81:1415-59. 2001
  90. pmc Abnormal angiogenesis but intact hematopoietic potential in TGF-beta type I receptor-deficient mice
    J Larsson
    Molecular Medicine and Gene Therapy, Institute of Laboratory Medicine and Department of Medicine, Lund University Hospital, Lund, Sweden
    EMBO J 20:1663-73. 2001
  91. pmc Vascular endothelium as a contributor of plasma sphingosine 1-phosphate
    Krishnan Venkataraman
    Center for Vascular Biology, Department of Cell Biology, University of Connecticut Health Center, Farmington, CT 06030, USA
    Circ Res 102:669-76. 2008
    ..These data suggest that the vascular endothelium, in addition to the hematopoietic system, is a major contributor of plasma S1P.
  92. ncbi Cloning of a unique lipase from endothelial cells extends the lipase gene family
    K Hirata
    Division of Cardiology, Stanford University Medical School, Stanford, California, 94305, USA
    J Biol Chem 274:14170-5. 1999
    ..Its tissue-restricted pattern of expression and its ability to be expressed by endothelial cells, suggests that endothelial cell-derived lipase may have unique functions in lipoprotein metabolism and in vascular disease...
  93. pmc Cyclic AMP potentiates vascular endothelial cadherin-mediated cell-cell contact to enhance endothelial barrier function through an Epac-Rap1 signaling pathway
    Shigetomo Fukuhara
    Department of Structural Analysis, National Cardiovascular Center Research Institute, 5 7 1 Fujishirodai, Suita, Osaka 565 8565, Japan
    Mol Cell Biol 25:136-46. 2005
    ..In conclusion, cAMP-Epac-Rap1 signaling promotes decreased cell permeability by enhancing VE-cadherin-mediated adhesion lined by the rearranged cortical actin...
  94. ncbi Assessment of the tissue distribution of transplanted human endothelial progenitor cells by radioactive labeling
    Alexandra Aicher
    Department of Molecular Cardiology, University of Frankfurt, Frankfurt, Germany
    Circulation 107:2134-9. 2003
    ..However, tissue distribution of transplanted EPCs has not yet been monitored in living animals. Therefore, we tested whether radioactive labeling allows us to detect injected EPCs...
  95. ncbi Race-specific differences in endothelial function: predisposition of African Americans to vascular diseases
    Leszek Kalinowski
    Department of Biochemistry, Ohio University, Athens, OH 45701, USA
    Circulation 109:2511-7. 2004
    ..We hypothesized that the differences in endothelial NO/O2-/ONOO- metabolism may highlight the potential predisposition to endothelial dysfunction and cardiovascular complications prevalent in blacks...
  96. ncbi The role of the vascular endothelial growth factor-Delta-like 4 ligand/Notch4-ephrin B2 cascade in tumor vessel remodeling and endothelial cell functions
    Patricia Hainaud
    Institut des Vaisseaux et du Sang, INSERM U689, IFR139, Paris VII Denis Diderot, Hopital Lariboisiere, Paris, France
    Cancer Res 66:8501-10. 2006
    ..Our study strongly suggests that a coordinated activation of DDL4/Notch4 and ephrin B2 pathways downstream of VEGF plays a key role in the abnormal remodeling of tumor vessels...
  97. ncbi Insulin receptor substrate-1 and phosphoinositide-dependent kinase-1 are required for insulin-stimulated production of nitric oxide in endothelial cells
    Monica Montagnani
    Cardiology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892 1755, USA
    Mol Endocrinol 16:1931-42. 2002
    ..Furthermore, classical Ca2+-mediated pathways for activation of eNOS are separable from IRS-1- and PDK-1-dependent insulin-signaling pathways...
  98. ncbi Replicative senescence of human endothelial cells in vitro involves G1 arrest, polyploidization and senescence-associated apoptosis
    M Wagner
    Abteilung Molekular-und Zellbiologie, Institut f. Biomedizinische Alternsforschung der Osterreichischen Akademie der Wissenschaften, Rennweg 10, A-6020 Innsbruck, Austria
    Exp Gerontol 36:1327-47. 2001
    ..The data imply that age-dependent apoptosis is a regular feature of human endothelial cells and suggest cell type specific differences in human ageing...
  99. ncbi Pigment epithelium-derived factor inhibits angiogenesis via regulated intracellular proteolysis of vascular endothelial growth factor receptor 1
    Jun Cai
    School of Optometry and Vision Sciences, Cardiff University, UK
    J Biol Chem 281:3604-13. 2006
    ..This confirms the importance of PEDF and VEGFR-1 in the negative regulation of angiogenesis...
  100. ncbi Endothelial function: a barometer for cardiovascular risk?
    Joseph A Vita
    Circulation 106:640-2. 2002
  101. ncbi Myeloperoxidase, a leukocyte-derived vascular NO oxidase
    Jason P Eiserich
    Department of Internal Medicine, Division of Nephrology, University of California, Davis, CA 95616, USA
    Science 296:2391-4. 2002
    ..Altered vascular responsiveness was due to catalytic consumption of NO by substrate radicals generated by MPO. Thus MPO can directly modulate vascular inflammatory responses by regulating NO bioavailability...

Research Grants79

  1. Comparison of Diesel and Biodiesel Emissions and Health Effects in Underground Mi
    Jefferey L Burgess; Fiscal Year: 2013
    ..Ultrasound of brachial flow-mediated dilation will be used to evaluate changes in vascular endothelium function...
  2. A novel peroxidase in vascular endothelium and the development of atherosclerosis
    Guangjie Cheng; Fiscal Year: 2012
    ..Furthermore, we anticipate this research will lead to the development of a new drug that inhibits the enzyme's activity and blocks the change of LDL. ..
    Francis W Luscinskas; Fiscal Year: 2013
    ..The vascular endothelium plays an active and vital role in regulating inflammatory responses and in maintaining homeostasis of the ..
  4. Ischemia/Reperfusion Injury of Human Endothelium: Role of Glucose and Statins
    THOMAS JAY EBERT; Fiscal Year: 2013
    ..from I/R injury by volatile anesthetics might be explained by an effect of the volatile anesthetics on vascular endothelium. Anesthetic preconditioning (APC), i.e...
  5. Scavenging of Reactive Oxygen and Nitrogen Species by Cobalamins
    NICOLA ELIZABETH BRASCH; Fiscal Year: 2011
    ..CNCbl is the common Cbl form in vitamin supplements and is reduced to Cbl(II) upon entering cells. The vascular endothelium plays an important role in regulating blood flow, in inhibiting platelet aggregation and in the immune and ..
  6. Sphingosine 1-phosphate receptors in vascular homeostasis and pathology
    TIMOTHY TUN HLA; Fiscal Year: 2012
    ..The central hypothesis of this proposal is that S1P profoundly regulates the phenotype of vascular endothelium by temporally- and spatially-precise signaling of S1P1R and S1P2R...
  7. Endothelin-1 and androgen in prostate cancer bone metastasis and bone health
    Gregory A Clines; Fiscal Year: 2013
    ..provided by applicant): Endothelin-1 (ET-1) is a 21 amino acid potent vasoconstrictor and product of vascular endothelium. ET-1 is also a tumor-secreted factor that has a central role in osteoblast activation and the ..
  8. Over-Expression of microRNA-126 in Macrophages for Treatment of Atherosclerosis
    Suzette Laing; Fiscal Year: 2013
    ..The goal of this study is to determine 1) if macrophages can successful deliver miR-126 to the vascular endothelium, 2) If delivery of miR-126 to the vessel wall protects the endothelium thereby decreasing atherosclerotic ..
  9. Surveillance of Serum Contents by Mast Cells and Regulation of Allergic Immunity
    Laurence E Cheng; Fiscal Year: 2013
    ..Preliminary data indicate that tissue mast cells extend projections into the vascular endothelium as a means to capture IgE and respond to allergen...
  10. Estradiol-Induced Sialyation Of NCAM Prevents Leucocyte:Endothelial Adhesion
    Frederick Naftolin; Fiscal Year: 2010
    ..In the case of the vascular endothelium, the result may be minimization of leukocyte adhesion and sub endothelial inflammation, which would ..
  11. Mechanisms of endothelial barrier phenotypes in sickle cell disease
    ..We hypothesize that increased permeability of the vascular endothelium is a disorder of SCD that has not previously been appreciated...
  12. Role of VEGF in Perinatal Hypertension
    STEVEN HERBERT ABMAN; Fiscal Year: 2013
    ..endothelial growth factor (VEGF) is a potent mitogen and critical survival and maintenance factor for lung vascular endothelium. VEGF and its down-stream mediator, nitric oxide (NO), are essential for lung angiogenesis during early ..
  13. The Transcobalamin Receptor in Cobalamin Homeostasis
    Edward V Quadros; Fiscal Year: 2011
    ..cell types is mediated by transcobalamin (TC), a Cbl binding protein in the circulation, secreted by the vascular endothelium and a ubiquitous transcobalamin receptor (TCblR/CD320) that specifically binds TC saturated with Cbl and ..
  14. Optimization of KCa2 Channel Activators as Neuroscience Tools and Potential Drugs
    Heike Wulff; Fiscal Year: 2012
    ..Unfortunately, SKA-31 also activates KCa3.1 channels, which are expressed on vascular endothelium, and thus reduces blood pressure in mice...
  15. Endothelial SK3 Channel Modulation of EDHF is Estrogen Regulated
    Mike T Lin; Fiscal Year: 2011
    ..Ca2+ signaling in vascular endothelium is a key regulator for many of the endothelium-derived vasoactive factors, including endothelins, ..
  16. The Role of Complement in Airway Microvascular Disease
    MARK ROBERT NICOLLS; Fiscal Year: 2013
    ..Prior to the development of airway fibrosis in rejecting allografts, C3 deposits on the vascular endothelium just as tissue hypoxia is first detected...
  17. Effect of Diet on Inflammation in Sicke Cell Mice
    Jacqueline M Hibbert; Fiscal Year: 2010
    ..In sickle cell anemia patients, abnormal adherence of 'sickled'red cells to vascular endothelium induces local inflammation via sub-clinical ischemia, vasoocclusion, reperfusion and hemolysis...
  18. Coordination of Pathophysiologic Endothelial Cell Signaling by ROS
    Madesh Muniswamy; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE The pulmonary vascular endothelium plays a key role in lung heath by translating blood signals into vascular function...
  19. Homing of Stem Cells in Stroke Therapeutics
    EVAN YALE contact SNYDER; Fiscal Year: 2010
    ..It is unknown whether this works, however, for brain vascular endothelium. It is also unknown whether this works for NSCs -- again, the "gold standard" -- although they, too, have ..
  20. Role of Endothelin B Receptor in Vascular Protection in Females
    Raouf A Khalil; Fiscal Year: 2011
    ..Also, experimental data have suggested protective effects of estrogen (E2) on the vascular endothelium by affecting the release of vasodilator factors such as nitric oxide and vasoconstrictive factors such as ..
  21. Ozone Cardiovascular Effects in Genetically Susceptible People
    MARK WALTER FRAMPTON; Fiscal Year: 2012
    ..We hypothesize that ozone exposure delivers an oxidative burden to the lung and to the vascular endothelium, via lipid peroxidation and secondary reactive oxygen and nitrogen species (ROS)...
  22. Obesity, vascular inflammation, and immune cell activation in prehypertension
    Suzi Hong; Fiscal Year: 2013
    ..A comprehensive picture of orchestrated biological events in the vascular endothelium will be investigated by following: vascular dysfunction will be assessed by flow mediated brachial artery ..
  23. Adiponetin and AMPK Biosensor
    John Y J Shyy; Fiscal Year: 2010
    ..In vascular endothelium, Adipo binding to the Adipo receptors elicits AMP-activated protein kinase (AMPK) to phosphorylate/activate ..
  24. CAP37 and ocular inflammation
    HELOISE ANNE PEREIRA; Fiscal Year: 2011
    ..The induction of a host defense molecule in the outermost layers of the eye and in the vascular endothelium in response to infection, suggests that it could play a key role in regulating inflammation and healing in ..
  25. The role of Histidine rich protein II in cerebral malaria
    Priya Pal; Fiscal Year: 2013
    ..Cerebral malaria pathophysiology is thought to center along the vascular endothelium and is characterized by increased inflammatory cytokines, vascular leakage and a high parasite burden both ..
  26. IGF-1, oxidative stress and telomere dynamics in cultured human somatic cells
    Rivka C Stone; Fiscal Year: 2012
    ..e., proliferation and increased oxidative stress. However, in the human vascular endothelium, the effect of IGF-1 is tilted towards endothelial NOS (eNOS)...
  27. Thioredoxin and Endothelial Cell Function
    Wang Min; Fiscal Year: 2012
    ..We will study the effects of a antioxidant protein thioredoxin, on vascular endothelium. Our work may lead to better tests and treatments for atherosclerosis patients.
  28. MiR-181b, endothelial cells, and vascular inflammation
    Mark W Feinberg; Fiscal Year: 2013
    ..highlight a critical role for enhanced NF-kB pathway activation in atherosclerotic tissues including the vascular endothelium. Proinflammatory cytokines and proatherogenic risk factors such as hyperlipidemia lead to NF-kB activation, ..
  29. Role of Maternal Platelets in the Placenta and Pregnancy Complications
    Rashmi Sood; Fiscal Year: 2013
    ..The maternal vascular spaces in the placenta are lined by fetal trophoblast cells, rather than the maternal vascular endothelium. It is unclear how blood flow is maintained in these vascular spaces and what leads to pathological ..
  30. Identification of CNS-homing peptides for therapeutic use in multiple sclerosis
    Kamal D Moudgil; Fiscal Year: 2013
    ..We hypothesize that the vascular endothelium of the CNS is characterized by unique molecular markers that facilitate both selective migration of the ..
  31. Enhancement of Coronary Constriction by Volatile Organic Air Toxics
    Matthew J Campen; Fiscal Year: 2013
    ..Despite the protective barrier afforded by the lung, the systemic vascular endothelium is a vulnerable target of air pollution toxicity and sensitive to the combinations of PM and gas components...
  32. PPAR gamma regulates vascular endothelial reactive species production in diabetes
    C Michael Hart; Fiscal Year: 2012
    ..factor, peroxisome proliferator-activated receptor gamma (PPARg) controls a program of gene expression in vascular endothelium that regulates the balance between the production of reactive nitrogen and oxygen species and that PPARg ..
  33. Cytochrome P4501A1 and Vascular Injury
    Mary K Walker; Fiscal Year: 2012
    ..Thus, we will test the hypothesis that over expression of CYP1A1 in vascular endothelium significantly increases ROS which induce vascular dysfunction and angiotensin (Ang) II-dependent ..
  34. Endothelial Dysfunction in Older Adult Humans with the Metabolic Syndrome
    DEMETRA CHRISTOU; Fiscal Year: 2009
    ..The proposed research will determine if blockade of the mineralocorticoid receptors improves vascular endothelium-dependent dilation, a clinically relevant marker of endothelial function, in middle-aged and older adults ..
  35. Structure and Function of Endothelial Fenestrae
    RADU VIRGIL STAN; Fiscal Year: 2010
    The main function of the vascular endothelium is the mediation and control of the transendothelial exchanges of water and solutes (both small and large molecules) between blood plasma and the interstitial fluid, in short the control of ..
  36. Mitofusins in endothelial mitochondrial signaling and endothelial cell function
    GLADYS AFOR NGOH; Fiscal Year: 2013
    ..An intact vascular endothelium is critical for the proper functioning of tissues such as muscle, heart and brain...
  37. Novel High Affinity VEGF Analogs For Targeted Imaging of Thyroid Cancer
    BRUCE DALE WEINTRAUB; Fiscal Year: 2013
    ..VEGF which can be used in novel, targeted imaging of such tumors to the VEGFR2 receptor in both the stromal vascular endothelium and in tumor epithelium, as supported by extensive and compelling preliminary data...
  38. Immunological Mechanisms in Systemic Autoimmune Disease
    Ann Marshak-Rothstein; Fiscal Year: 2012
    ..that allows for the regulated expression of a "pseudo- autoantigen" on either MHC class II+ cells or on the vascular endothelium, and the potential for expression by other tissues known to be targeted in SSc...
  39. KLF2 as a regulator of endothelial cell biology
    MUKESH KUMAR JAIN; Fiscal Year: 2012
    Abstract: The vascular endothelium produces numerous growth factors, cytokines, and bioactive mediators that critically regulate vascular homeostasis in health and disease...
  40. Lung Endothelial Cell Apoptosis and Emphysema
    SHARON IRENE SMITH ROUNDS; Fiscal Year: 2013
    ..relevant to veterans'health in that these studies will determine the mechanism of injury to the lung vascular endothelium caused by tobacco and the role that this plays in development of COPD...
  41. Targeted Delivery of a Novel Synthetic Curcumin Analog, EF24 to Glioblastoma and
    MAMORU NONE SHOJI; Fiscal Year: 2012
    ..We have demonstrated that both GBM tumor cells and its vascular endothelium express the cell surface receptor tissue factor (TF), a critical initiator of thrombosis, while the ..
  42. 2010 Gordon Research Conference on Endothelial Cell Phenotypes in Health and Dise
    Edward Conway; Fiscal Year: 2010
    ..the role of the endothelial cell in the placenta, pregnancy and eclampsia, 3. the eye and the vascular endothelium, 4. understanding the endothelium in tissue engineering, 5...
  43. Epidemic Typhus Pathogenesis
    Sanjeev K Sahni; Fiscal Year: 2010
    ..prowazekii. Strikingly, the knowledge of molecular aspects of interactions with the vascular endothelium, the preferred cell type infected during human infections, still remains in its infancy...
  44. Perinatal regulation of endothelial NOS
    Stephen M Black; Fiscal Year: 2010 a complex interaction of vasoactive substances, such as NO and ET-1, that are produced locally by the vascular endothelium and we propose to investigate the role of NO, ET-1, and their interactions, in mediated the dynamic changes ..
  45. LRP1 and endothelial function
    Xinchun Pi; Fiscal Year: 2013
    ..The dysregulation of the vascular endothelium in response to vascular injury and stress contributes to many cardiovascular diseases such as inflammation, ..
  46. Homocysteine: Vascular Biochemistry and Metabolism
    DONALD WELDON JACOBSEN; Fiscal Year: 2010
    ..Cysteine transporters mediate homocysteine import in the vascular endothelium. Evidence is provided that links homocysteine targeting to vascular cell dysfunction...
  47. Injury and Recovery in Developing Brain
    Flora M Vaccarino; Fiscal Year: 2013
    ..of neural stem cells and progenitors, which requires specific growth factors in neural stem cells and vascular endothelium;(2) survival of newly-born neuronal and glial populations, which requires improved energetic metabolism in ..
    Michael B Fallon; Fiscal Year: 2013
    ..and ETB receptor mediated effects contribute to adhesion and activation of monocytes/macrophages in the pulmonary vascular endothelium and 3) assess the role of ETB receptor alterations in the pathogenesis of experimental HPS in vivo.
  49. Functions of the Hypoxia-Induced MicroRNA-210 in Pulmonary Vascular Endothelium
    Stephen Y Chan; Fiscal Year: 2013
    ..In doing so, it is expected to improve the current understanding of the mechanisms by which low oxygen conditions affect the pulmonary vessels during normal and disease states and may point to future therapeutic targets. ..
  50. Modeling Immune Desensitization in Renal Transplantation
    Martin S Zand; Fiscal Year: 2013
    ..Anti-ABO antibodies cause rejection of kidney transplants by binding to donor vascular endothelium, leading to macrovascular thrombosis and organ loss...
  51. Analysis and Characterization of Trauma-Induced Coagulopathy
    Stephen R Wisniewski; Fiscal Year: 2013
    ..proposal provides a comprehensive evaluation of the contributions of plasma proteins, blood cells, the vascular endothelium, the blood vessel, and extravascular tissue to TIC, making use of a unique infrastructure that includes ..
  52. Asthma is a Prognostic Indicator for Pulmonary Metastasis of Breast Cancer
    JAMES JOSEPH LEE; Fiscal Year: 2010
    ..tumors that have entered peripheral and/or lymphatic circulation;subsequent cell-cell interactions with the vascular endothelium lead to adhesion and extravasation from circulation...
    James M May; Fiscal Year: 2013
    ..This gluco/lipotoxicity is especially damaging to the vascular endothelium, where it impairs endothelial function and increases endothelial permeability to blood constituents...
    Joe G N Garcia; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): This PPG renewal (years 11-15) remains focused on the lung vascular endothelium as a dynamic cellular barrier which is perturbed in inflammatory lung injury...
    CHARLES LEFFLER; Fiscal Year: 2009
    ..of heme oxygenase, HO-2, is expressed in highest concentration in the brain where it resides in neurons, vascular endothelium and smooth muscle. It generates CO from cellular heme...
    Jonathan A Epstein; Fiscal Year: 2012
    ..Our lab has shown that the gene causing Neurofibromatosis, Nf1, functions in vascular endothelium and smooth muscle;and preliminary data indicates that Nf1 is important in cardiac myocytes as well...
  57. Vascular Endothelium Directs the Development of Regulatory T Cells
    Daniel Kreisel; Fiscal Year: 2010
    ..primary aim of this grant proposal is to investigate the immunological consequences of interactions between vascular endothelium and allogeneic CD4+ T lymphocytes...
  58. Drug Delivery to CNS Endothelial Cells by Targeting Peptide-MHC Complexes
    Ulrich Bickel; Fiscal Year: 2009
    ..application is to establish specific peptide- major histocompatibility (MHC) class I complexes on brain vascular endothelium as viable portals for drug delivery...
  59. RIPK-dependent necrosis in development and cancer
    Douglas R Green; Fiscal Year: 2013
    ..In this aim, we will test the idea that early progenitors of vascular endothelium and hematopoietic cells serve as the earliest and most important targets of this developmental defect...
  60. Regulation of vascular inflammation by mitochondrial reactive oxygen species
    Brian J Hawkins; Fiscal Year: 2012
    ..The vascular endothelium is the structural lining of all blood vessels that serves as an active barrier between the circulation and ..
  61. Lactation Effects on Postnatal Endothelial Function and Vascular Inflammation
    Karen M Grewen; Fiscal Year: 2013 the perimenopause, may therefore be a critical period of enhanced risk for inflammatory damage to vascular endothelium. The central hypothesis is that lactation reduces cardiovascular risk through its salutary effects on ..
  62. A Tumor Suppressor Function for the c-Fes Tyrosine Kinase in Colon Cancer
    THOMAS EDWARD SMITHGALL; Fiscal Year: 2012
    ..c-Fes protein-tyrosine kinase is associated with differentiation signaling in myeloid hematopoietic cells, vascular endothelium and neurons...
  63. Intervention strategies of hemorrhagic colitis and HUS
    Edgar Boedeker; Fiscal Year: 2004
    ..the most severe intestinal and renal manifestations of EHEC infection result from toxin-mediated damage to vascular endothelium, with tissue edema, inflammatory infiltrates, cytokine production and vascular thrombi...
  64. Regulatory Oxygenases in Vasculopathic Rickettsioses
    SANJEEV SAHNI; Fiscal Year: 2010
    ..prowazekii. Rickettsiae are obligate intracellular parasites characterized by tropism for vascular endothelium of their mammalian hosts...
    CHARLES COLLARD; Fiscal Year: 2001
    ..abstract) Ischemia-reperfusion injury leads to the activation and deposition of serum complement on the vascular endothelium. Inhibition of complement activation or depletion of complement proteins prior to reperfusion has been ..
    Michael Heymann; Fiscal Year: 1999
    ..Although recent physiological advances have highlighted the role of the vascular endothelium in contributing to these changes, of primary importance in this respect are nitric oxide (NO) and PGI2, ..
    Eugene Levin; Fiscal Year: 2001
    ..and functional characteristics of endothelial cells in vivo and in vitro have established that the vascular endothelium is made up of a phenotypically diverse group of cells...
    William Pearce; Fiscal Year: 1992
    ..First, experiments will be conducted to test the hypothesis that the vascular endothelium makes a greater contribution to hypoxic relaxation in adult than in newborn cerebral arteries...
    Edgar Boedeker; Fiscal Year: 1999
    ..The most severe intestinal and renal manifestations result from toxin-mediated damage to vascular endothelium, with tissue edema, inflammatory infiltrates, cytokine production and vascular thrombi...
    George Palade; Fiscal Year: 2000
    DESCRIPTION (Adapted from Investigator's Abstract): The vascular endothelium performs critical functions in the physiology of mammals, men included...
  71. GATA Factor Regulation of Vascular Endothelium
    EMERY BRESNICK; Fiscal Year: 2009
    ..Gata2 in hematopoietic cells as a foundation, studies are proposed to elucidate how GATA-2 functions in vascular endothelium. The Gata2 locus contains five "GATA switch sites" that are occupied by GATA-2 and GATA-1 at the active and ..
  72. Therapeutic Angiogenesis for Erectile Dysfunction
    BRIAN ANNEX; Fiscal Year: 2009
    ..that erectile function is an integrated vascular process that is dependent on interactions between the vascular endothelium, nerves and cavernosal smooth muscle;with nitric oxide (NO) the principal mediator of this process...
    JOE GARCIA; Fiscal Year: 2001
    The vascular endothelium is a selective cellular barrier to circulatory proteins and is critical to vessel wall homeostasis. Increased endothelial cell permeability occurs in acute lung injury resulting in profound physiologic derangement...
    Louis Picker; Fiscal Year: 1999
    ..the applicant's Abstract): A T lymphocyte's ability to home, ie to recognize, bind and extravasate through vascular endothelium, is a critical element in its functional repertoire...
    KAMAL MOUDGIL; Fiscal Year: 2005
    ..We propose that the synovial vascular endothelium displays unique molecular markers, including homing molecules that facilitate efficient trafficking of ..
    Steven Rosen; Fiscal Year: 2009
    ..Importantly, non-PNAd ligands for L-selectin exist on HEVs, other vascular endothelium and subpopulations of leukocytes...
  77. Role of p38 MAPK in IL-4-induced IL-6 expression in vascular endothelium
    Yongwoo Lee; Fiscal Year: 2007
    ..Previous studies have suggested that interleukin-6 (IL-6)-induced pro-inflammatory environments in the vascular endothelium are critical for the initiation and development of atherosclerosis...
  78. The role of the vascular endothelium in schistosomiasis
    Melissa Beall; Fiscal Year: 2002
    ..of their host, with intimate contact occurring between the dorsal surface of the male parasite and the vascular endothelium of the host...
    Linda Bradley; Fiscal Year: 2001
    ..Chemokines regulate adhesion of cells to vascular endothelium and, via chemoattractant effects, govern cellular recruitment into inflammatory lesions...