vasa vasorum

Summary

Summary: Nutrient blood vessels which supply the walls of large arteries or veins.

Top Publications

  1. ncbi Simvastatin preserves the structure of coronary adventitial vasa vasorum in experimental hypercholesterolemia independent of lipid lowering
    Stephanie H Wilson
    Divisions of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55905, USA
    Circulation 105:415-8. 2002
  2. ncbi Hypertension and hypercholesterolemia differentially affect the function and structure of pig carotid artery
    Daniele Versari
    Division of Cardiovascular Diseases, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Hypertension 50:1063-8. 2007
  3. ncbi A new method for assessment of plaque vulnerability based on vasa vasorum imaging, by using contrast-enhanced intravascular ultrasound and differential image analysis
    Manolis Vavuranakis
    First Department of Cardiology, Hippokration Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece
    Int J Cardiol 130:23-9. 2008
  4. ncbi Vasa vasorum and plaque neovascularization on contrast-enhanced carotid ultrasound imaging correlates with cardiovascular disease and past cardiovascular events
    Daniel Staub
    Department of Internal Medicine, Rush University Medical Center, Chicago, IL 60612, USA
    Stroke 41:41-7. 2010
  5. ncbi Inflammatory angiogenesis in atherogenesis--a double-edged sword
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy
    Ann Med 40:606-21. 2008
  6. ncbi Intravascular ultrasound-based imaging of vasa vasorum for the detection of vulnerable atherosclerotic plaque
    Sean M O'Malley
    Visual Computing Lab, Dept of Computer Science, Univ of Houston, USA
    Med Image Comput Comput Assist Interv 8:343-51. 2005
  7. ncbi Contrast ultrasound imaging of the carotid artery vasa vasorum and atherosclerotic plaque neovascularization
    Steven B Feinstein
    Rush Presbyterian St Luke s Medical Center, Chicago, Illinois 60612, USA
    J Am Coll Cardiol 48:236-43. 2006
  8. ncbi OX40 ligand plays an important role in the development of atherosclerosis through vasa vasorum neovascularization
    Makoto Nakano
    Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi, Aoba ku Sendai 980 8574, Japan
    Cardiovasc Res 88:539-46. 2010
  9. ncbi Experimental angiogenesis of arterial vasa vasorum
    Ilana M Bayer
    Toronto General Research Institute, University Health Network, Toronto, ON, Canada
    Cell Tissue Res 307:303-13. 2002
  10. pmc The dynamic vasa vasorum
    Erik L Ritman
    Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Cardiovasc Res 75:649-58. 2007

Detail Information

Publications183 found, 100 shown here

  1. ncbi Simvastatin preserves the structure of coronary adventitial vasa vasorum in experimental hypercholesterolemia independent of lipid lowering
    Stephanie H Wilson
    Divisions of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55905, USA
    Circulation 105:415-8. 2002
    ..have demonstrated that experimental hypercholesterolemia leads to neovascularization in the coronary artery vasa vasorum (VV)...
  2. ncbi Hypertension and hypercholesterolemia differentially affect the function and structure of pig carotid artery
    Daniele Versari
    Division of Cardiovascular Diseases, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Hypertension 50:1063-8. 2007
    ..to compare the effects of hypertension and hypercholesterolemia on carotid endothelial function, structure, and vasa vasorum density...
  3. ncbi A new method for assessment of plaque vulnerability based on vasa vasorum imaging, by using contrast-enhanced intravascular ultrasound and differential image analysis
    Manolis Vavuranakis
    First Department of Cardiology, Hippokration Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece
    Int J Cardiol 130:23-9. 2008
    Increased neovascularization in vasa vasorum and atherosclerotic plaques has recently been identified as a common feature of inflammation and plaque vulnerability...
  4. ncbi Vasa vasorum and plaque neovascularization on contrast-enhanced carotid ultrasound imaging correlates with cardiovascular disease and past cardiovascular events
    Daniel Staub
    Department of Internal Medicine, Rush University Medical Center, Chicago, IL 60612, USA
    Stroke 41:41-7. 2010
    Histological data associate proliferation of adventitial vasa vasorum and intraplaque neovascularization with vulnerable plaques represented by symptomatic vascular disease...
  5. ncbi Inflammatory angiogenesis in atherogenesis--a double-edged sword
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy
    Ann Med 40:606-21. 2008
    The adventitia and the outer layers of media of an atherosclerosis-prone arterial wall are vascularized by vasa vasorum. Upon growth of an atherosclerotic lesion in the intima, neovascular sprouts originating from the adventitial vasa ..
  6. ncbi Intravascular ultrasound-based imaging of vasa vasorum for the detection of vulnerable atherosclerotic plaque
    Sean M O'Malley
    Visual Computing Lab, Dept of Computer Science, Univ of Houston, USA
    Med Image Comput Comput Assist Interv 8:343-51. 2005
    ..These plaques are known to be chronically inflamed. The vasa vasorum (VV) are microvessels that nourish vessel walls...
  7. ncbi Contrast ultrasound imaging of the carotid artery vasa vasorum and atherosclerotic plaque neovascularization
    Steven B Feinstein
    Rush Presbyterian St Luke s Medical Center, Chicago, Illinois 60612, USA
    J Am Coll Cardiol 48:236-43. 2006
    ..direct, real-time visualization of neovasculature of the atherosclerotic plaque and associated adventitial vasa vasorum. With continued clinical investigation, CU imaging of the carotid artery may afford an effective means to non-..
  8. ncbi OX40 ligand plays an important role in the development of atherosclerosis through vasa vasorum neovascularization
    Makoto Nakano
    Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi, Aoba ku Sendai 980 8574, Japan
    Cardiovasc Res 88:539-46. 2010
    Atherosclerosis is characterized by infiltration of inflammatory cells and enhanced vasa vasorum formation, for which immunological mechanisms may be involved...
  9. ncbi Experimental angiogenesis of arterial vasa vasorum
    Ilana M Bayer
    Toronto General Research Institute, University Health Network, Toronto, ON, Canada
    Cell Tissue Res 307:303-13. 2002
    b>Vasa vasorum are important sources of oxygen and nutrients to vascular tissues and their proliferation influences the pathogenesis of arterial disease; however, the regulation of their growth is poorly understood partly because of a lack ..
  10. pmc The dynamic vasa vasorum
    Erik L Ritman
    Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Cardiovasc Res 75:649-58. 2007
    The function of vasa vasorum is both to deliver nutrients and oxygen to arterial and venous walls and to remove "waste" products, either produced by cells in the wall or introduced by diffusional transport through the endothelium of the ..
  11. ncbi Neovascularization in human atherosclerosis
    P R Moreno
    The Zena and Michael A Wiener Cardiovascular Institute, and the Marie Josee and Henry R Kravis Cardiovascular Health Center, The Mount Sinai School of Medicine, New York, NY 10029, USA
    Curr Mol Med 6:457-77. 2006
    ..We will review the structure and function of vasa vasorum in health and disease, the mechanisms responsible for the angiogenic process, the role of the immune system, ..
  12. ncbi Increased spatial vasa vasorum density in the proximal LAD in hypercholesterolemia--implications for vulnerable plaque-development
    Mario Gossl
    Department of Internal Medicine, Division of Cardiovascular Diseases, Mayo Clinic College of Medicine, Rochester, MN 55905, United States
    Atherosclerosis 192:246-52. 2007
    b>Vasa vasorum (VV) neovascularization is associated with advanced and ruptured atherosclerotic lesions that occur predominantly within the proximal third of the LAD...
  13. ncbi Hypoxia-inducible factor-1alpha/vascular endothelial growth factor pathway for adventitial vasa vasorum formation in hypertensive rat aorta
    Fumitaka Kuwahara
    Cardiovascular Research Institute and Internal Medicine III, Kurume University School of Medicine, Kurume, Japan
    Hypertension 39:46-50. 2002
    The roles of adventitial vasa vasorum have been highlighted in vascular wall homeostasis. Vascular endothelial growth factor (VEGF) is a potent angiogenic factor in physiological and pathophysiological conditions...
  14. ncbi Differential distribution of vasa vasorum in different vascular beds in humans
    Heike A Hildebrandt
    Department of Internal Medicine, Division of Cardiovascular Diseases, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Atherosclerosis 199:47-54. 2008
    b>Vasa vasorum (VV) have been implicated to play a role in the pathogenesis of atherosclerosis...
  15. ncbi Dysfunctional vasa vasorum in diabetic peripheral artery obstructive disease with critical lower limb ischaemia
    C Orrico
    Department of Specialistic Surgical and Anaestesiological Sciences, S Orsola Malpighi Hospital University of Bologna, Via Massarenti, 9 Bld 5, 40126 Bologna, Italy
    Eur J Vasc Endovasc Surg 40:365-74. 2010
    To establish whether in diabetic patients with peripheral artery obstructive disease (PAOD) vasa vasorum (vv) neoangiogenesis is altered with increased arterial damage.
  16. ncbi Experimental hypercholesterolemia differentially affects adventitial vasa vasorum and vessel structure of the left internal thoracic and coronary arteries
    Offer Galili
    Division of Cardiovascular Diseases, Mayo College of Medicine, Rochester, MN 55905, USA
    J Thorac Cardiovasc Surg 129:767-72. 2005
    ..Recent evidence suggests a role for the vasa vasorum in the atherosclerotic process...
  17. ncbi Will the real plaque vasculature please stand up? Why we need to distinguish the vasa plaquorum from the vasa vasorum
    Zorina S Galis
    Department of Surgery, Indiana University, Indianapolis, IN 46236, USA
    Trends Cardiovasc Med 19:87-94. 2009
    ..to refer to the neovasculature located within the atherosclerotic plaque to distinguish it clearly from vasa vasorum, the native, supporting vasculature of the artery...
  18. ncbi Vasa vasorum imaging: a new window to the clinical detection of vulnerable atherosclerotic plaques
    Stephane Carlier
    Association for Eradication of Heart Attack AEHA, 2472 Bolsover 439, Houston, TX 77005, USA
    Curr Atheroscler Rep 7:164-9. 2005
    ..contrast-enhanced IVUS can measure activity and inflammation within atherosclerotic plaques by imaging vasa vasorum density...
  19. ncbi Coronary vasa vasorum neovascularization precedes epicardial endothelial dysfunction in experimental hypercholesterolemia
    J Herrmann
    Division of Cardiovascular Diseases, Mayo Clinic Rochester, 200 First Street S.W, Rochester, MN 55905, USA
    Cardiovasc Res 51:762-6. 2001
    OBJECTIVE: Experimental hypercholesterolemia is associated with vasa vasorum neovascularization, unknown to occur before or after initial lesion formation...
  20. pmc Chronic hypoxia impairs extracellular nucleotide metabolism and barrier function in pulmonary artery vasa vasorum endothelial cells
    Gennady G Yegutkin
    MediCity Research Laboratory, University of Turku and National Institute of Health and Welfare, Tykistokatu 6A, 20520, Turku, Finland
    Angiogenesis 14:503-13. 2011
    ..By using vasa vasorum endothelial cells (VVEC) isolated from pulmonary artery adventitia of control and chronically hypoxic neonatal ..
  21. ncbi Small-vessel vasculitis surrounding an uninflamed temporal artery and isolated vasa vasorum vasculitis of the temporal artery: two subsets of giant cell arteritis
    Giovanna Restuccia
    Arcispedale Santa Maria Nuova, Reggio Emilia, Italy
    Arthritis Rheum 64:549-56. 2012
    To evaluate the frequency and clinical characteristics of periadventitial small-vessel vasculitis (SVV) and isolated vasa vasorum vasculitis (VVV).
  22. ncbi Chronic endothelin receptor antagonism prevents coronary vasa vasorum neovascularization in experimental hypercholesterolemia
    Joerg Herrmann
    Division of Cardiovascular Diseases, Mayo Clinic Rochester, Rochester, Minnesota 55905, USA
    J Am Coll Cardiol 39:1555-61. 2002
    The purpose of this study was to test the hypothesis that endothelin (ET) receptor antagonism reduces coronary vasa vasorum neovascularization in experimental hypercholesterolemia.
  23. ncbi New advances in noninvasive imaging of the carotid artery: CIMT, contrast-enhanced ultrasound, and vasa vasorum
    Blai Coll
    Unitat de Diagnòstic i Tractament de Malalties Aterotrombòtiques UDETMA, Hospital Arnau de Vilanova, Institut de Recerca Biomèdica, Lleida, Spain
    Curr Cardiol Rep 12:497-502. 2010
    ..We discuss the use CIMT and other emerging techniques such as contrast-enhanced carotid ultrasound imaging in the evaluation of the carotid artery and its value in cardiovascular disease...
  24. ncbi Architectonic arrangement of the vasa vasorum of the human great saphenous vein
    David Kachlik
    Department of Anatomy, Third Faculty of Medicine, Charles University, Prague, Czech Republic
    J Vasc Res 44:157-66. 2007
    The detailed spatial arrangement of the vasa vasorum (VV) of the human great saphenous vein (HGSV) was demonstrated in qualitative and quantitative terms.
  25. ncbi Hypoxia-induced pulmonary artery adventitial remodeling and neovascularization: contribution of progenitor cells
    Neil J Davie
    Developmental Lung Biology Group, UCHSC, 4200 East 9 th Ave, Rm 3419, Denver, CO 80262, USA
    Am J Physiol Lung Cell Mol Physiol 286:L668-78. 2004
    Information is rapidly emerging regarding the important role of the arterial vasa vasorum in a variety of systemic vascular diseases...
  26. pmc P2Y1 and P2Y13 purinergic receptors mediate Ca2+ signaling and proliferative responses in pulmonary artery vasa vasorum endothelial cells
    Taras Lyubchenko
    Dept of Pediatrics, University of Colorado Denver, Research 2, Box B131, Aurora, CO 80045, USA
    Am J Physiol Cell Physiol 300:C266-75. 2011
    Extracellular ATP and ADP have been shown to exhibit potent angiogenic effects on pulmonary artery adventitial vasa vasorum endothelial cells (VVEC)...
  27. pmc Prevention of vasa vasorum neovascularization attenuates early neointima formation in experimental hypercholesterolemia
    Mario Gossl
    Division of Cardiovascular Diseases, Mayo Clinic College of Medicine, Rochester, MN, USA
    Basic Res Cardiol 104:695-706. 2009
    b>Vasa vasorum (VV) neovascularization is a key feature of early atherosclerosis and adds substantial endothelial exchange-surface to the coronary vessel wall...
  28. pmc Extracellular ATP is a pro-angiogenic factor for pulmonary artery vasa vasorum endothelial cells
    Evgenia V Gerasimovskaya
    Department of Pediatrics, University of Colorado at Denver and Health Sciences Center, B131, 4200 East 9th Ave, Denver, CO 80262, USA
    Angiogenesis 11:169-82. 2008
    Expansion of the vasa vasorum network has been observed in a variety of systemic and pulmonary vascular diseases...
  29. pmc The vasa vasorum in diseased and nondiseased arteries
    Mary Jo Mulligan-Kehoe
    Department of Surgery, Vascular Section, Dartmouth Medical School, Borwell 530E, One Medical Center Drive, Lebanon, NH 03756, USA
    Am J Physiol Heart Circ Physiol 298:H295-305. 2010
    The vasa vasorum form a network of microvasculature that originate primarily in the adventitial layer of large arteries. These vessels supply oxygen and nutrients to the outer layers of the arterial wall...
  30. pmc Molecular imaging of inflammation and intraplaque vasa vasorum: a step forward to identification of vulnerable plaques?
    Gerrit L Ten Kate
    Division of Pharmacology, Vascular and Metabolic Diseases, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    J Nucl Cardiol 17:897-912. 2010
    ..Intraplaque neovascularization sprouting from the adventitial vasa vasorum has been identified as an independent predictor of intraplaque hemorrhage and plaque rupture...
  31. ncbi Contrast-enhanced ultrasound for imaging vasa vasorum: comparison with histopathology in a swine model of atherosclerosis
    Arend F L Schinkel
    Department of Internal Medicine, Section of Cardiology, Rush University Medical Center, Chicago, IL, USA
    Eur J Echocardiogr 11:659-64. 2010
    ..To evaluate the agreement between contrast-enhanced ultrasound imaging and histopathology in an animal model of atherosclerosis...
  32. pmc Quantification of vasa vasorum density in multi-slice computed tomographic coronary angiograms: role of computed tomographic image voxel size
    Regina Moritz
    Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, MN, USA
    J Comput Assist Tomogr 34:273-8. 2010
    This study is motivated by the possibility of using computed tomography (CT) to detect early coronary atherosclerosis by the increased CT values within the arterial wall resulting from vasa vasorum proliferation.
  33. ncbi MR imaging of adventitial vasa vasorum in carotid atherosclerosis
    W S Kerwin
    Department of Radiology, University of Washington, Seattle, Washington, USA
    Magn Reson Med 59:507-14. 2008
    b>Vasa vasorum in the adventitia of atherosclerotic arteries may play a role in plaque progression...
  34. pmc PI3K, Rho, and ROCK play a key role in hypoxia-induced ATP release and ATP-stimulated angiogenic responses in pulmonary artery vasa vasorum endothelial cells
    Heather N Woodward
    Department of Pediatrics, 12700 E 19th Ave, University of Colorado Denver, Research Complex 2, Box B131, Aurora, CO 80045, USA
    Am J Physiol Lung Cell Mol Physiol 297:L954-64. 2009
    We recently reported that vasa vasorum expansion occurs in the pulmonary artery (PA) adventitia of chronically hypoxic animals and that extracellular ATP is a pro-angiogenic factor for isolated vasa vasorum endothelial cells (VVEC)...
  35. ncbi Role of vasa vasorum in transendothelial solute transport in the coronary vessel wall: a study with cryostatic micro-CT
    Mario Gossl
    Physiological Imaging Research Laboratory, Dept of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, 200 First St SW, Rochester, MN 55905, USA
    Am J Physiol Heart Circ Physiol 287:H2346-51. 2004
    Using cryostatic microscopic computed tomography (micro-CT), we sought to determine the role of coronary vasa vasorum (VV) in transendothelial solute transport in arteries with normal and increased permeability due to high plasma ..
  36. ncbi Vasa vasorum growth in the coronary arteries of newborn pigs
    Mario Gossl
    Physiological Imaging Research Laboratory, Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Anat Embryol (Berl) 208:351-7. 2004
    Experimental studies have shown that a "plexus" of vasa vasorum already exists in fetal arteries. In this study we examine the further development of vasa vasorum in the newborn...
  37. ncbi Impact of coronary vasa vasorum functional structure on coronary vessel wall perfusion distribution
    M Gossl
    Department of Physiology and Biophysics, Physiological Imaging Research Laboratory, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Am J Physiol Heart Circ Physiol 285:H2019-26. 2003
    Noncoronary vasa vasorum have been described as networks of microvessels in the wall of arteries and veins...
  38. ncbi Functional anatomy and hemodynamic characteristics of vasa vasorum in the walls of porcine coronary arteries
    Mario Gossl
    Physiological Imaging Research Laboratory, Department of Physiology and Biophysics, Mayo Clinic, Rochester, Minnesota 55905, USA
    Anat Rec A Discov Mol Cell Evol Biol 272:526-37. 2003
    In this study vasa vasorum in the walls of porcine coronary arteries were examined, using three-dimensional (3D) micro-CT scanning techniques...
  39. ncbi Extracellular adenosine triphosphate: a potential regulator of vasa vasorum neovascularization in hypoxia-induced pulmonary vascular remodeling
    Evgenia V Gerasimovskaya
    University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Chest 128:608S-610S. 2005
  40. ncbi Correlation of vasa vasorum neovascularization and plaque progression in aortas of apolipoprotein E(-/-)/low-density lipoprotein(-/-) double knockout mice
    Alexander C Langheinrich
    Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Arterioscler Thromb Vasc Biol 26:347-52. 2006
    We hypothesized that apolipoprotein E (apoE)(-/-)/low-density lipoprotein (LDL)(-/-) double knockout mice might develop vasa vasorum (VV) in association with advanced lesion formation.
  41. ncbi Molecular imaging of atherosclerotic plaques using a human antibody against the extra-domain B of fibronectin
    Christian M Matter
    Cardiovascular Research, Institute of Physiology, University of Zurich and Cardiovascular Center, Zurich University Hospital, Switzerland
    Circ Res 95:1225-33. 2004
    ..expression of ED-B not only in murine but also in human plaques, in which it was found predominantly around vasa vasorum and plaque matrix...
  42. pmc The antiangiogenic activity of rPAI-1(23) inhibits vasa vasorum and growth of atherosclerotic plaque
    Mary Drinane
    Angiogenesis Research, Dartmouth Medical School, Lebanon, NH 03756, USA
    Circ Res 104:337-45. 2009
    ..However, there is a paucity of information regarding the origin of plaque vasculature and the role of vasa vasorum in plaque growth...
  43. pmc Inhibition of plaque neovascularization reduces macrophage accumulation and progression of advanced atherosclerosis
    Karen S Moulton
    Department of Surgery, Children s Hospital Medical Center and Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 100:4736-41. 2003
    ..We observe vasa vasorum density correlates highly with the extent of inflammatory cells, not the size of atheromas in apolipoprotein E-..
  44. pmc Endothelin alters the reactivity of vasa vasorum: mechanisms and implications for conduit vessel physiology and pathophysiology
    R Scotland
    Centre for Clinical Pharmacology, University College London, Rayne Institute, 5 University St, London, WC1E 6JJ
    Br J Pharmacol 128:1229-34. 1999
    1 The walls of certain large blood vessels are nourished by the vasa vasorum, a network of microvessels that penetrate the adventitia and media of the vessel wall...
  45. ncbi Vasa vasorum and atherosclerosis - Quid novi?
    Alexander C Langheinrich
    University of Giessen, Department of Radiology, Giessen, Germany
    Thromb Haemost 97:873-9. 2007
    The role of vasa vasorum (VV) in atherosclerosis is hotly debated, and new experimental techniques have recently opened an opportunity to take a fresh look at this important topic...
  46. pmc Segmental heterogeneity of vasa vasorum neovascularization in human coronary atherosclerosis
    Mario Gossl
    Division of Cardiovascular Diseases, Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    JACC Cardiovasc Imaging 3:32-40. 2010
    Our aim was to investigate the role of coronary vasa vasorum (VV) neovascularization in the progression and complications of human coronary atherosclerotic plaques.
  47. ncbi Arterial neovascularization and inflammation in vulnerable patients: early and late signs of symptomatic atherosclerosis
    Michael Fleiner
    Department of Medicine, University Hospital Bruderholz, Bruderholz, Switzerland
    Circulation 110:2843-50. 2004
    ....
  48. ncbi Vasa vasorum neovascularization and lesion distribution among different vascular beds in ApoE-/-/LDL-/- double knockout mice
    Alexander C Langheinrich
    Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Alfred 2 409, 200 First St SW, Rochester, MN 55905, USA
    Atherosclerosis 191:73-81. 2007
    ..In view of some evidence that there are different distributions of adventitial vasa vasorum (VV) in different vascular beds, and that this correlates with lesion formation, we explored this possible ..
  49. pmc Low vasa vasorum densities correlate with inflammation and subintimal thickening: potential role in location--determination of atherogenesis
    M Gossl
    Department of Internal Medicine, Division of Cardiovascular Diseases, Mayo Clinic College of Medicine, Rochester, MN 55905, United States
    Atherosclerosis 206:362-8. 2009
    To assess the role of coronary vasa vasorum (VV) spatial distribution in determining the location of early atherosclerotic lesion development.
  50. ncbi Review and Hypothesis: Vulnerable plaque formation from obstruction of Vasa vasorum by homocysteinylated and oxidized lipoprotein aggregates complexed with microbial remnants and LDL autoantibodies
    Uffe Ravnskov
    1Independent Investigator, Magle Stora Kyrkogata 9, 22350 Lund, Sweden
    Ann Clin Lab Sci 39:3-16. 2009
    ..Because of high extra-capillary tissue pressure, aggregates of such complexes may be trapped in vasa vasorum of the major arteries...
  51. ncbi Vasa vasorum hypoxia: initiation of atherosclerosis
    Matti Järvilehto
    Department of Biology, University of Oulu, 90014 Oulu, Finland
    Med Hypotheses 73:40-1. 2009
    We propose a new hypothesis pointing of a functional hypoxia in vasa vasorum, which might explain the initiation and the early development of the atherosclerosis in the deep layer of intima...
  52. ncbi Contrast-enhanced ultrasound imaging of periadventitial vasa vasorum in human carotid arteries
    Marco Magnoni
    Department of Cardiothoracic and Vascular Diseases, University Vita Salute, San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan, Italy
    Eur J Echocardiogr 10:260-4. 2009
    Arterial vasa vasorum (VV) are known to be involved in the atherosclerotic process...
  53. ncbi 3-Deazaadenosine inhibits vasa vasorum neovascularization in aortas of ApoE(-/-)/LDL(-/-) double knockout mice
    Alexander C Langheinrich
    Department of Radiology, Justus Liebig University Giessen, Klinikstr 36, 35385 Giessen, Germany
    Atherosclerosis 202:103-10. 2009
    Atherosclerosis and inflammation/angiogenesis are strongly associated including growth of vasa vasorum (VV) and plaque neovascularization, but a causative role for neovascularization has still not been established...
  54. ncbi Differential effect of experimental hypertension and hypercholesterolemia on adventitial remodeling
    Joerg Herrmann
    Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic Rochester, MN 55905, USA
    Arterioscler Thromb Vasc Biol 25:447-53. 2005
    ..Intima-media remodeling, as frequently assessed by changes in the external elastic lamina-to-lumen area (EELLA), is well-described in coronary artery disease in contrast to adventitial remodeling, especially in the early disease stage...
  55. ncbi Neovascularization in human atherosclerosis
    Pedro R Moreno
    Zena and Michael A Wiener Cardiovascular Institute, Marie Josee and Henry R Kravis Cardiovascular Health Center, Mount Sinai School of Medicine, New York, NY 10029, USA
    Circulation 113:2245-52. 2006
  56. ncbi Elimination of neoangiogenesis for plaque stabilization: is there a role for local drug therapy?
    Frank D Kolodgie
    CVPath Institute, Gaithersburg, Maryland, USA
    J Am Coll Cardiol 49:2093-101. 2007
    ..Plaque hemorrhage results from the development of immature neointimal vasa vasorum. Therefore, it is proposed that molecular therapies designed to eliminate pathologic neovascularization within ..
  57. ncbi Adventitial growth factor signalling and vascular remodelling: potential of perivascular gene transfer from the outside-in
    Richard C M Siow
    Cardiovascular Division, School of Medicine, King s College London, 150 Stamford Street, London SE1 9NH, United Kingdom
    Cardiovasc Res 75:659-68. 2007
    ..providing a supportive connective tissue and extracellular matrix scaffold around vessels for nerves and the vasa vasorum. We and others have recently demonstrated that functional changes in cells within the adventitia contribute to ..
  58. ncbi Detection of carotid adventitial vasa vasorum and plaque vascularization with ultrasound cadence contrast pulse sequencing technique and echo-contrast agent
    Edoardo Vicenzini
    Stroke 38:2841-3. 2007
    Adventitial vasa vasorum and plaque vascularization have been established as predictors of unstable atheromasic lesions in cerebro- and cardiovascular patients...
  59. ncbi Deposition of amyloid proteins in the epicardial coronary arteries of 58 patients with primary systemic amyloidosis
    Christopher M Wittich
    Department of Internal Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Cardiovasc Pathol 16:75-8. 2007
    ..We sought to determine the distribution and the effect of amyloid on epicardial coronary arteries in patients with primary cardiac amyloidosis...
  60. ncbi Transcription factor SOX18 is expressed in human coronary atherosclerotic lesions and regulates DNA synthesis and vascular cell growth
    Marta Garcia-Ramírez
    Centro de Investigacion Cardiovascular, CSIC ICCC, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    Arterioscler Thromb Vasc Biol 25:2398-403. 2005
    ..We analyzed SOX18 expression in human coronary atherosclerotic lesions and investigated its potential function in vascular cells...
  61. ncbi Nonlinear intravascular ultrasound contrast imaging
    David E Goertz
    Biomedical Engineering Department, Erasmus Medical Centre, Rotterdam, The Netherlands
    Ultrasound Med Biol 32:491-502. 2006
    ..These results suggest the feasibility of harmonic IVUS contrast imaging, which may have applications in coronary lumen boundary detection and vasa vasorum imaging.
  62. ncbi Contrast harmonic intravascular ultrasound: a feasibility study for vasa vasorum imaging
    David E Goertz
    Biomedical Engineering Dept, Thoraxcenter, Erasmus Medical Centre, Rotterdam, The Netherlands
    Invest Radiol 41:631-8. 2006
    We sought to investigate feasibility of vasa vasorum imaging using the novel technique of contrast harmonic intravascular ultrasound.
  63. ncbi The absence of lymphatics in normal and atherosclerotic coronary arteries in man: a morphologic study
    O Eliska
    Department of Anatomy, 1st Medical Faculty, Charles University, Prague, Czech Republic
    Lymphology 39:76-83. 2006
    ..In all coronary arteries studied, and particularly in the atherosclerotic lesions, blood vasa vasorum could be visualized...
  64. ncbi Angiogenesis-dependent and independent phases of intimal hyperplasia
    Rohit Khurana
    Centre for Cardiovascular Biology and Medicine, Department of Medicine, University College, London, UK
    Circulation 110:2436-43. 2004
    ..Because percutaneous coronary interventions result in induction of periadventitial angiogenesis, we analyzed the role of this process in neointima formation...
  65. ncbi Human saphenous vein and coronary bypass surgery: ultrastructural aspects of conventional and "no-touch" vein graft preparations
    S R Ahmed
    Department of Anatomy and Developmental Biology and Centre for Neuroscience, University College London, London, UK
    Histol Histopathol 19:421-33. 2004
    ..These features are suggested to contribute to the improved early patency rate described using the no-touch technique of SV harvesting...
  66. ncbi Increased expression of thrombospondin-1 in vessel wall of diabetic Zucker rat
    Olga I Stenina
    Joseph J Jacobs Center for Thrombosis and Vascular Biology, Department of Molecular Cardiology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Circulation 107:3209-15. 2003
    ..Thus, TSP-1 expression in the blood vessel wall may increase, providing a molecular link between diabetes and accelerated vascular lesion development...
  67. ncbi Inner layer infarction of the coronary artery wall due to coronary thrombosis
    Waldemar Hort
    Department of Pathology, Heinrich Heine University, Moorenstrasse 5, 40225 Dusseldorf, Germany
    Virchows Arch 441:490-3. 2002
    ..This noninfarcted wall tissue was supplied by vasa vasorum in the adventitia located at an average distance of approximately 40 micro m from the media...
  68. ncbi Tissue and serum angiogenic activity is associated with low prevalence of ischemic complications in patients with giant-cell arteritis
    Maria C Cid
    Vasculitis Research Unit, Department of Internal Medicine, Hospital Clinic, University of Barcelona, Institut d Investigacions Biomediques August Pi i Sunyer, Barcelona, Spain
    Circulation 106:1664-71. 2002
    ..Vascular inflammatory lesions from patients with giant-cell arteritis show a remarkable amount of neovascularization, but its clinical implications have never been investigated...
  69. ncbi VEGF regulates remodeling during permanent anatomic closure of the ductus arteriosus
    Ronald I Clyman
    Cardiovascular Research Institute, University of California, San Francisco, California 94143 0544, USA
    Am J Physiol Regul Integr Comp Physiol 282:R199-206. 2002
    ..The mAbVEGF treatment produced a significant (P < 0.05) reduction in ductus vasa vasorum ingrowth and neointima formation (due to both a decrease in luminal endothelial cell proliferation and a ..
  70. ncbi Adventitial vasa vasorum heterogeneity among different vascular beds
    Offer Galili
    Division of Cardiovascular Diseases, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    J Vasc Surg 40:529-35. 2004
    ..Recent evidence suggests a role for the vasa vasorum (VV) in vascular disease...
  71. ncbi Imaging of the vasa vasorum
    Juan F Granada
    Skirball Center for Cardiovascular Research, Cardiovascular Research Foundation, New York, NY, USA
    Nat Clin Pract Cardiovasc Med 5:S18-25. 2008
    Neovascularization of the arterial walls by adventitial vasa vasorum appears to participate in the process of atherosclerosis progression and destabilization...
  72. ncbi [Pathogenesis of atherosclerosis in patients with lipid metabolism disturbances: hypothesis on cholesterol utilization and atheromatous plaque formation]
    G V Chepelenko
    Department of angiography and reentgenography, N A Semashko Central Clinical Hospital, Ministry of Railway Transport, Moscow, Russia
    Angiol Sosud Khir 9:20-5. 2003
    ..high density lipoproteins (HDL) owing to their structural damage after local vascular wall ischemia caused by vasa vasorum disorders...
  73. ncbi Hypothesis: a potential role for the vasa vasorum in the maintenance of vein graft patency
    Michael R Dashwood
    Department of Clinical Biochemistry, Royal Free and University College Medical School, London, United Kingdom
    Angiology 55:385-95. 2004
    ..Within these regions are situated the vasa vasorum and small vessels providing oxygen and nutrients to the vessel wall...
  74. pmc Vascular ossification-calcification in metabolic syndrome, type 2 diabetes mellitus, chronic kidney disease, and calciphylaxis-calcific uremic arteriolopathy: the emerging role of sodium thiosulfate
    Melvin R Hayden
    Department of Family and Community Medicine, University of Missouri Columbia, PO BOX 1140 Lk Rd 5 87, Camdenton, Missouri 65020, USA
    Cardiovasc Diabetol 4:4. 2005
    ..The endothelium seems to be at the very center of these disease processes, acting as the first line of defense against these multiple metabolic toxicities and the first to encounter their damaging effects to the arterial vessel wall...
  75. ncbi Mechanisms and consequences of large artery rigidity
    Karima Et-Taouil
    Department of Medicine Nephrology, Institute of Pharmacology, 3001 12th Avenue North, University of Sherbrooke, Sherbrooke, QC J1H 5N4, Canada
    Can J Physiol Pharmacol 81:205-11. 2003
    ..Functional abnormalities, such as bradykinin-dependent hyper-reactivity of smooth muscle cells and vasa vasorum microcirculation network disturbances, also appear to alter aortic wall rigidity...
  76. ncbi Cryostatic micro-computed tomography imaging of arterial wall perfusion
    Birgit Kantor
    Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    Scanning 24:186-90. 2002
    ..The detection of contrast in the adventitia suggest that vasa vasorum deliver the contrast agent from the main lumen to the adventitial extravascular space but not to the media.
  77. ncbi Prefabricated engineered skin flap using an arteriovenous vascular bundle as a vascular carrier in rabbits
    Yoshio Tanaka
    Division of Plastic and Reconstructive Surgery, Shinko Hospital, Kobe, Japan
    Plast Reconstr Surg 117:1860-75. 2006
    ..They hypothesized that increased tissue volume could be obtained by the application of basic fibroblast growth factor (bFGF) and/or by increasing the chamber size and porosity...
  78. ncbi Clinical analysis of acute type A intramural hematoma: comparison between two different pathophysiological types
    Kunihide Nakamura
    Department of Surgery 2, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan
    Ann Thorac Surg 81:1587-92. 2006
    Type A intramural hematoma (IMH) has two different etiologies, which are rupture of vasa vasorum and penetrating atherosclerotic ulcer (PAU); however, it is difficult to know which is the initiating event.
  79. ncbi Hemoglobin-based oxygen carrier distribution inside vascular wall and arterial pressure evolution: is there a relationship?
    Y Smani
    Department of Hematology and Physiology, EA 3452 Faculty of Pharmacy, University Henri Poincare Nancy I, Nancy, France
    Eur Surg Res 37:1-8. 2005
    ..17 min by confocal microscopy showed the presence of free Hb in or upon endothelial cells (EC) in intima and in vasa vasorum. At 180 min, the free Hb was found in or upon EC and inside all abdominal aortic wall meanwhile MAP recovered ..
  80. ncbi Cell contribution of vasa-vasorum to early arterial intimal thickening formation
    L Diaz-Flores
    Department of Pathology, Histology and Radiology, School of Medicine, La Laguna University, Canary Islands, Spain
    Histol Histopathol 22:1379-86. 2007
    ....
  81. ncbi Mild inflammatory activation of mammary arteries in patients with acute coronary syndromes
    Chiara Foglieni
    Clinical Cardiovascular Biology Laboratory and Cardiac Surgery Unit, Cardiothoracic and Vascular Department, University Vita Salute, San Raffaele Scientific Institute, Milano, Italy
    Am J Physiol Heart Circ Physiol 294:H2831-7. 2008
    ..7% vs. CSA 17.6%, P = 0.001 for class I; and ACS 66.7% vs. CSA 6.2%, P = 0.0003 for class II-DR) and on the vasa vasorum (ACS 92.9% vs. CSA 33.3% and 7.7%, P = 0.0007 and P < 0...
  82. ncbi Lack of sumatriptan-induced aortic contraction or relaxation: 5-HT1B receptor protein detected in endothelium and smooth muscle of vasa vasorum but not aorta
    Marlene L Cohen
    Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA
    Receptors Channels 8:71-8. 2002
    ..However, dense 5-HT1B receptor protein was found in the vascular smooth muscle of the vasa vasorum supplying the aorta...
  83. ncbi Descending vasa recta endothelium is an electrical syncytium
    Qingli Zhang
    Division of Nephrology N3W143, University of Maryland School of Medicine, 22 S Greene Street, Baltimore, MD 21201, USA
    Am J Physiol Regul Integr Comp Physiol 291:R1688-99. 2006
    ..We conclude that the DVR endothelium is an electrical syncytium and that gap junction coupling in DVR pericytes exists but is less pronounced...
  84. ncbi The corrupted feedback hypothesis
    T P Crotty
    University College Cork, Ireland
    Med Hypotheses 61:605-16. 2003
    ..The acute varicosity is believed to transform into the permanent type seen in varicose veins if the factor responsible for it persists long enough...
  85. ncbi The Mikamo Lecture 2002. Therapeutic targets for the treatment of atherothrombosis in the new millennium--clinical frontiers in atherosclerosis research
    Valentin Fuster
    The Zena and Michael Wiener Cardiovascular Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    Circ J 66:783-90. 2002
  86. ncbi Frontiers in nephrology: early atherosclerosis--a view beyond the lumen
    Mario Gossl
    Division of Cardiovascular Diseases, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    J Am Soc Nephrol 18:2836-42. 2007
    ..Recent research indicates that the coronary vessel wall, especially the vasa vasorum, as well as bone marrow-derived endothelial progenitor cells may be subject to proatherosclerotic changes, even ..
  87. ncbi Low glucose enhances Na+/glucose transport in bovine brain artery endothelial cells
    T Nishizaki
    Department of Physiology, Kobe University School of Medicine, Japan
    Stroke 29:844-9. 1998
    Brain arteries are structurally characterized by the tight junctions of the endothelium and by no vasa vasorum that feed arteries themselves. This raises the question of how brain arteries are provided with glucose...
  88. ncbi A study of the course of the internal carotid artery in the parapharyngeal space and its clinical importance
    Zuhal Ozgur
    Department of Anatomy, Faculty of Medicine, Ege University, Izmir Bornova, 35100, Turkey
    Eur Arch Otorhinolaryngol 264:1483-9. 2007
    ..specimens demonstrated depletion and decreasing muscle tissue in tunica media and an increase was observed in vasa vasorum numbers in the tunica adventitia of ICA...
  89. ncbi Temporal arteritis associated with systemic necrotizing vasculitis
    Mohamed A Hamidou
    Department of Internal Medicine and Laboratory of Pathology, University Hospital Hotel Dieu, Place Alexis Ricordeau, Nantes 44035, France
    J Rheumatol 30:2165-9. 2003
    ..To evaluate the clinical and laboratory characteristics of patients with systemic vasculitis associated with temporal artery involvement...
  90. ncbi Effect of blood viscosity on oxygen transport in residual stenosed artery following angioplasty
    Ohwon Kwon
    Department of Mechanical Engineering, University of Cincinnati, Cincinnati, OH 45221, USA
    J Biomech Eng 130:011003. 2008
    ..using different hematocrit (Hct) concentrations, oxygen consumption by the avascular wall and its supply from vasa vasorum, nonlinear oxygen binding capacity of the hemoglobin, and basal to hyperemic flow rate changes are included in ..
  91. ncbi Varicocele is associated with an increase of connective tissue of the pampiniform plexus vein wall
    Massimo Iafrate
    Department of Oncological and Surgical Sciences, Urology Clinic, University of Padua, Monoblocco Ospedaliero, IV Floor, Via Giustiniani 2, Padua 35128, Italy
    World J Urol 27:363-9. 2009
    ..The purpose of this study is to describe the normal structure of spermatic vein wall and the morphological alterations in patients with grades 1-3 varicocele...
  92. ncbi [The use of positron emission tomography (18F-FDG PET) in diagnosing chronic periaortitis]
    P Nemec
    II interní klinika Lékarské fakulty MU a FN u sv Anny Brno
    Vnitr Lek 54:1093-9. 2008
    ..authors, chronic periaortitis results from a systemic autoimmune inflammation with vasculitis affecting aortal vasa vasorum and medium and small calibre retroperitoneal vessels...
  93. ncbi [Intramural hemorrhage of the thoracic aorta: diagnosis, therapy and prognosis of 209 in vivo diagnosed cases]
    Y von Kodolitsch
    Universitätskrankenhaus Eppendorf Innere Medizin II Abteilung für Kardiologie, Hamburg
    Z Kardiol 87:797-807. 1998
    ..the term "mediastinal apoplexy" IMH may--similar to cerebral apoplexy--result from hypertensive rupture of the vasa vasorum in the aortic media...
  94. ncbi Early recruitment of phagocytes contributes to the vascular inflammation of giant cell arteritis
    Dirk Foell
    Department of Paediatrics, University of Munster, Germany
    J Pathol 204:311-6. 2004
    ..In contrast, S100A12 expression was restricted to neutrophils that were found around the vasa vasorum within the adventitial layer...
  95. ncbi The complex structure of the smooth muscle layer of spermatic veins and its potential role in the development of varicocele testis
    Derya Tilki
    Department of Urology, University Hospital Grosshadern Munich, Marchioninistrasse 15, D 81377 Munich, Germany
    Eur Urol 51:1402-9; discussion 1410. 2007
    ..The exact mechanism of varicocele development is not clarified yet. This study focused on the structure of varicocele veins, compared with normal spermatic veins, and its potential role in varicocele development...
  96. ncbi Morphology of umbilical vessels in human fetuses: a quantitative light microscope study
    M A Malas
    Department of Anatomy, Suleyman Demirel University, Medical Faculty, Isparta, Turkey
    Eur J Morphol 41:167-74. 2003
    ..To investigate the development of the intra-abdominal part of the umbilical vessels in human fetuses by light microscopy...
  97. ncbi Calcitonin receptor immunoreactivity associated with specific cell types in diseased radial and internal mammary arteries
    P J Wookey
    Departments of Cardiology, Medicine University of Melbourne, and Cardiac Surgery, Austin Health, Heidelberg, Victoria, Australia
    Histopathology 52:605-12. 2008
    ..and quantify calcitonin receptor (CTR) immunoreactivity associated with specific cell types within, and associated with, the endothelial layers, neo-intima, media and vasa vasorum of diseased radial and internal mammary arteries.
  98. ncbi Human smooth muscle myosin heavy chain isoforms as molecular markers for vascular development and atherosclerosis
    M Aikawa
    Third Department of Internal Medicine, University of Tokyo, Japan
    Circ Res 73:1000-12. 1993
    ..However, smaller-sized arteries, like the vasa vasorum of the aorta or intramyocardial coronary arterioles, were negative for SMemb...
  99. ncbi Adeno-associated virus vectors for vascular gene delivery
    C M Lynch
    Targeted Genetics Corp, Seattle, Wash 98101, USA
    Circ Res 80:497-505. 1997
    ..was intraluminal or adventitial, transduction was observed in the adventitia, particularly within microvessels (vasa vasorum) but not in cells of the intima or media...
  100. ncbi The mink as an animal model for Pseudomonas aeruginosa adhesion: binding of the bacterial lectins (PA-IL and PA-IIL) to neoglycoproteins and to sections of pancreas and lung tissues from healthy mink
    Svend Kirkeby
    Department of Oral Medicine, Dental School, University of Copenhagen, Nørre Allé 20, DK 2200 Copenhagen, Denmark
    Microbes Infect 9:566-73. 2007
    ..PA-IL reacted with the capillaries in the alveolar walls and with the small blood vessels forming the vasa vasorum around the larger vessels, while PA-IIL marked the goblet cells in the bronchial surface epithelium...
  101. ncbi Smooth muscle cell modulation and cytokine overproduction in varicose veins. An in situ study
    C Badier-Commander
    INSERM U460, UFR X Bichat, 16 rue H Huchard, 75870 Paris Cedex 18, France
    J Pathol 193:398-407. 2001
    ..suggesting modulation from a contractile to a proliferative and synthetic phenotype; furthermore, the number of vasa vasorum was increased. In contrast, in atrophic portions, both cellular and matrix components were decreased...

Research Grants34

  1. Development of Porcine Genetic Models of Atherosclerosis
    SCOTT CHRISTOPHER FAHRENKRUG; Fiscal Year: 2011
    ..with regard to size, morphology, relative collateral arterial supply, and the presence of a well-developed vasa vasorum, the porcine coronary arterial model is the standard for the preclinical evaluation of endovascular devices...
  2. IVUS Detection of Rupture Prone Plaques
    Marvin M Doyley; Fiscal Year: 2013
    ..The microvascular networks or vasa vasorum of developing atherosclerotic plaques may function as a conduit for the migration of leukocytes and plasma ..
  3. Identifying Vulnerable Plaque in Rheumatoid Arthritis
    Kimberly P Liang; Fiscal Year: 2013
    ..Recently, increased neovascularization in vasa vasorum has been identified as a common feature of inflammation and plaque vulnerability, and has been found to be an ..
  4. Aortic Wall Behavior as a Predictor of Aortic Aneurysm Growth
    Rabih A Chaer; Fiscal Year: 2013
    ..AAA contrast ultrasound (CUS) microbubble imaging will detect AAA wall inflammation and neovascularization with vasa vasorum (VV)...
  5. Extracellular ATP as regulator of hypoxia-induced vasa vasorum neovascularization
    Evgenia V Gerasimovskaya; Fiscal Year: 2012
    ..that hypoxia-induced pulmonary artery (PA) remodeling is associated with marked increases in the density of vasa vasorum network...
  6. Sequencing Candidate Genes for Hyperplastic Vasculomyopathy
    Dianna Milewicz; Fiscal Year: 2009
    ..In addition, there was SMC hyperplasia causing occlusion of the vasa vasorum. These data lead to the hypothesis that mutations in genes encoding for other components of the SMC contractile ..
  7. Racial Differences in Atherosclerosis, Plaque Vulnerability, and CVD
    Steven E Reis; Fiscal Year: 2010
    ..SCORE by using microbubble contrast-enhanced B-mode ultrasonography to quantify carotid artery adventitial vasa vasorum density, which correlates with plaque vulnerability, and to accurately measure intimal-medial thickness of both ..
  8. Dual-frequency intravascular arrays for functional imaging of atherosclerosis
    XIAONING JIANG; Fiscal Year: 2013
    ..Recent research involving contrast enhanced vasa vasorum imaging and molecular imaging of plaque- associated inflammatory and angiogenic biomarkers suggests that these ..
  9. Cell Instructive Materials For Engineering Vascular Grafts
    Robert E Akins; Fiscal Year: 2013
    ..the central mechanisms that drive adventitial cell phenotype will afford instructive materials that can reduce stenosis, attenuate fibrosis, and encourage formation of healthy vasa vasorum to improve outcomes after vascular procedures.
  10. Molecular Targeting of Plaque Angiogenesis in Diabetes
    KAREN SIMPSON MOULTON; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Networks of small caliber blood vessels, termed vasa vasorum, are confined to the outer media and adventitia layers of major large caliber blood vessels;however, these vessels proliferate and invade ..
  11. Advanced IVUS Imaging with MUTs
    FAHRETTIN L DEGERTEKIN; Fiscal Year: 2010
    ..This study will also serve as a paradigm for a broad range of ultrasound imaging applications that would benefit from advanced transducer technology with integrated electronics. ..
  12. ADVENTITIA AND VASCULAR LESION FORMATION
    Josiah Wilcox; Fiscal Year: 2000
    ..hypothesis is that these responses are stimulated, in part, by a reduction of adventitia blood supply by the vasa vasorum caused by balloon inflation resulting in adventitia ischemia...
  13. Bronchial circulation blocks pulmonary oxidant injury
    David Pearse; Fiscal Year: 2006
    ..The systemic bronchial circulation interacts with the pulmonary circulation by supplying vasa vasorum to the pulmonary arteries and veins and draining via bronchopulmonary anastomoses into the capillary and post-..
  14. CHOLESTEROL & PLAQUE RUPTURE--WOMEN AND PLAQUE EROSION
    Renu Virmani; Fiscal Year: 2001
    ..deposition in plaques that rupture is derived from RBC membranes from recurrent hemorrhage of ruptured vasa vasorum. This in turn leads to a larger necrotic core size and higher macrophage recruitment, features of vulnerable ..
  15. Combined Therapeutic-Imaging Agent for Atherosclerosis
    Gregory Lanza; Fiscal Year: 2007
    ..Expansion of the network of small capillaries that perfuse the wall of larger blood vessels, the vasa vasorum, is recognized in diseases of chronic inflammation (e.g., atherosclerosis) and injury (e.g., angioplasty)...
  16. MATRIX METALLOPROTEINASE-9 AND ARTERIAL REMODELING
    Zorina Galis; Fiscal Year: 2004
    ..during carotid artery remodeling induced by vascular injury; and 4) Assess the role of MMP-9 in angiogenesis of vasa vasorum. Beyond our basic interest in MMP-9, we believe our model provides an opportunity to examine the contribution ..
  17. SUPPORT FOR CEREBROVASCULAR RESEARCH CENTER
    James Robertson; Fiscal Year: 1980
    ..To study and refine knowledge of the extracranial-intracranial vasa vasorum in humans and animals relating to fibrous dysplasia vascular repair and reactivity and microsurgical technique...
  18. Mechanisms of PAI-1 Induced Anti-Angiogenesis
    Mary J Mulligan Kehoe; Fiscal Year: 2011
    Neovascularization is associated with atherosclerosis and the vasa vasorum is the primary source of angiogenic vessels that supply the neovascularized area...
  19. Coronary Vasa Vasorum - Role of 3D Branching Geometry
    Erik Ritman; Fiscal Year: 2009
    This renewal proposal continues our exploration of the vasa vasorum (the microvessels perfusing the arterial wall) in coronary artery disease...
  20. NON INVASIVE MRI OF HUMAN VULNERABLE PLAQUE
    Valentin Fuster; Fiscal Year: 2001
    ..Overall, the projects represent highly interactive efforts of experienced investigators who will develop new approaches to the vulnerable plaque using molecular biology, animal models, clinical investigation, and MRI. ..
  21. MULTIDISCIPLINARY MICRO CT-3D IMAGING FACILITY
    Erik Ritman; Fiscal Year: 2001
    ..AIM IV - Continue to provide the 3D micro-CT imaging service to investigator-users so that this experience will guide innovation, improvement and/or expansion of the imaging repertoire of the micro-CT methodology. ..
  22. ORAL CYCLOPHOSPHAMIDE VS ORAL PLACEBO IN SSC ALVEOLITIS
    Dean Schraufnagel; Fiscal Year: 2003
    ..abstract_text> ..
  23. PROSTAGLANDIN SIGNALING IN FEMALE REPRODUCTION
    John Reese; Fiscal Year: 2005
    ..The results of these experiments will enhance the understanding of maternal-fetal PG signaling, and are likely to provide new insights into premature or dysfunctional labor in women. ..
  24. Closure of the Primate Ductus Arteriosus
    Ronald Clyman; Fiscal Year: 2006
    ..These studies should increase our understanding of how the patent ductus arteriosus alters pulmonary function in the preterm infant and what produces its permanent closure. ..
  25. In Vivo Myocardial Microcirculatory Function
    ERIK LEO RITMAN; Fiscal Year: 2010
    ..abstract_text> ..
  26. Mechanisms of Ductus Arteriosus Regulation
    JOHN JEFFREY REESE; Fiscal Year: 2010
    ..These studies will examine new roles for prostaglandins and their relationship with other vasoactive mediators during development. ..
  27. Commercialization of a Tissue Engineered Blood Vessel
    NICOLAS L HEUREUX; Fiscal Year: 2007
    ....
  28. Artery Wall Hypoxia and Intimal Hyperplasia
    Steven Santilli; Fiscal Year: 2009
    ..abstract_text> ..
  29. Coronary Endothelial Function in Humans
    Amir Lerman; Fiscal Year: 2006
    ..The success of this program has the potential to further both the research and mentoring endeavors of patient-oriented investigation and mentoring the next generation of patient-oriented researchers. ..
  30. ENDOTHELIN IN HUMANS CORONARY IN EARLY ATHEROSCLEROSIS
    Amir Lerman; Fiscal Year: 2003
    ....
  31. Micro-CT of Solute Transport in Organs & Tissue Scaffolds
    Erik Ritman; Fiscal Year: 2009
    ....