middle cerebral artery

Summary

Summary: The largest and most complex of the cerebral arteries. Branches of the middle cerebral artery supply the insular region, motor and premotor areas, and large regions of the association cortex.

Top Publications

  1. ncbi Dynamic cerebral autoregulation in acute lacunar and middle cerebral artery territory ischemic stroke
    Rogier V Immink
    Cardiovascular Research Institute Amsterdam, Department of Physiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Stroke 36:2595-600. 2005
  2. pmc Long-term prognosis of symptomatic isolated middle cerebral artery disease in Korean stroke patients
    Mi Sun Oh
    Department of Neurology, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, South Korea
    BMC Neurol 11:138. 2011
  3. doi Superficial temporal artery to middle cerebral artery bypass in acute ischemic stroke and stroke in progress
    Gyojun Hwang
    Department of Neurosurgery, Chuncheon Sacred Heart Hospital, Hallym University and Postgraduate School, Gangwon University, Chuncheon, Korea
    Neurosurgery 68:723-9; discussion 729-30. 2011
  4. doi Characterizing photothrombotic distal middle cerebral artery occlusion and YAG laser-induced reperfusion model in the Izumo strain of spontaneously hypertensive rats
    Hiroshi Yao
    National Hospital Organization Hizen Psychiatric Center, Saga, Japan
    Cell Mol Neurobiol 31:57-63. 2011
  5. doi Lesion patterns and stroke mechanisms in concurrent atherosclerosis of intracranial and extracranial vessels
    Bik Ling Man
    Division of Neurology, Department of Medicine and Geriatrics, Tuen Mun Hospital, Hong Kong, China
    Stroke 40:3211-5. 2009
  6. doi Early-stage investigations of ultrasmall superparamagnetic iron oxide-induced signal change after permanent middle cerebral artery occlusion in mice
    Virginie Desestret
    Universite Lyon, Lyon, France
    Stroke 40:1834-41. 2009
  7. ncbi Protective effect of resveratrol against oxidative stress in middle cerebral artery occlusion model of stroke in rats
    Kusum Sinha
    Neuropharmacology Laboratory, Department of Pharmacology, All India Institute of Medical Sciences, 110029, New Delhi, India
    Life Sci 71:655-65. 2002
  8. pmc Continuous estimates of dynamic cerebral autoregulation during transient hypocapnia and hypercapnia
    N E Dineen
    Ageing and Stroke Medicine Group, Department of Cardiovascular Sciences, University of Leicester, UK
    J Appl Physiol (1985) 108:604-13. 2010
  9. doi Spontaneous fluctuations in cerebral blood flow regulation: contribution of PaCO2
    R B Panerai
    Medical Physics Group, Department of Cardiovascular Sciences, University of Leicester National Health Service Trust, Leicester, UK
    J Appl Physiol (1985) 109:1860-8. 2010
  10. ncbi Randomized controlled study comparing effect of magnesium sulfate with placebo on fetal umbilical artery and middle cerebral artery blood flow in mild preeclampsia at ≥ 34 weeks gestational age
    Subhankar Dasgupta
    Department of Obstetrics and Gynecology, Bankura Sammilani Medical College, Bankura, India
    J Obstet Gynaecol Res 38:763-71. 2012

Detail Information

Publications310 found, 100 shown here

  1. ncbi Dynamic cerebral autoregulation in acute lacunar and middle cerebral artery territory ischemic stroke
    Rogier V Immink
    Cardiovascular Research Institute Amsterdam, Department of Physiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Stroke 36:2595-600. 2005
    We addressed whether dynamic cerebral autoregulation (dCA) is affected in middle cerebral artery (MCA) territory (MCAS) and lacunar ischemic stroke (LS).
  2. pmc Long-term prognosis of symptomatic isolated middle cerebral artery disease in Korean stroke patients
    Mi Sun Oh
    Department of Neurology, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, South Korea
    BMC Neurol 11:138. 2011
    This study aimed to investigate the long-term mortality and recurrence rate of stroke in first-time stroke patients with symptomatic isolated middle cerebral artery disease (MCAD) under medical management.
  3. doi Superficial temporal artery to middle cerebral artery bypass in acute ischemic stroke and stroke in progress
    Gyojun Hwang
    Department of Neurosurgery, Chuncheon Sacred Heart Hospital, Hallym University and Postgraduate School, Gangwon University, Chuncheon, Korea
    Neurosurgery 68:723-9; discussion 729-30. 2011
    ..Surgical reperfusion may be beneficial in patients with acute ischemic stroke who are ineligible for thrombolysis...
  4. doi Characterizing photothrombotic distal middle cerebral artery occlusion and YAG laser-induced reperfusion model in the Izumo strain of spontaneously hypertensive rats
    Hiroshi Yao
    National Hospital Organization Hizen Psychiatric Center, Saga, Japan
    Cell Mol Neurobiol 31:57-63. 2011
    ..A total of 166 male SHR/Izm and 17 male SHRSP/Izm were subjected to photothrombotic middle cerebral artery (MCA) occlusion with or without YAG laser-induced reperfusion. The pattern of distal MCA was recorded...
  5. doi Lesion patterns and stroke mechanisms in concurrent atherosclerosis of intracranial and extracranial vessels
    Bik Ling Man
    Division of Neurology, Department of Medicine and Geriatrics, Tuen Mun Hospital, Hong Kong, China
    Stroke 40:3211-5. 2009
    ..The typical lesion patterns and the mechanisms of stroke in patients with concurrent stenoses are unclear. This study aimed to determine these stroke features of such patients in Hong Kong...
  6. doi Early-stage investigations of ultrasmall superparamagnetic iron oxide-induced signal change after permanent middle cerebral artery occlusion in mice
    Virginie Desestret
    Universite Lyon, Lyon, France
    Stroke 40:1834-41. 2009
    ..Here, we compared MR signal changes after intravenous USPIO injection with the histological iron and macrophage distribution during the first 24 hours in a rodent model of acute stroke...
  7. ncbi Protective effect of resveratrol against oxidative stress in middle cerebral artery occlusion model of stroke in rats
    Kusum Sinha
    Neuropharmacology Laboratory, Department of Pharmacology, All India Institute of Medical Sciences, 110029, New Delhi, India
    Life Sci 71:655-65. 2002
    ..study the effect of chronic treatment of trans resveratrol was evaluated in focal ischemia induced by middle cerebral artery [MCA] occlusion in rats. Male Wistar rats were pretreated with trans resveratrol 20 mg/kg i.p...
  8. pmc Continuous estimates of dynamic cerebral autoregulation during transient hypocapnia and hypercapnia
    N E Dineen
    Ageing and Stroke Medicine Group, Department of Cardiovascular Sciences, University of Leicester, UK
    J Appl Physiol (1985) 108:604-13. 2010
    ....
  9. doi Spontaneous fluctuations in cerebral blood flow regulation: contribution of PaCO2
    R B Panerai
    Medical Physics Group, Department of Cardiovascular Sciences, University of Leicester National Health Service Trust, Leicester, UK
    J Appl Physiol (1985) 109:1860-8. 2010
    ..Continuous bilateral recordings of cerebral blood flow velocity (transcranial Doppler, middle cerebral artery), end-tidal Pco(2) (Pet(CO(2)), infrared capnograph), and blood pressure (Finapres) were obtained at rest ..
  10. ncbi Randomized controlled study comparing effect of magnesium sulfate with placebo on fetal umbilical artery and middle cerebral artery blood flow in mild preeclampsia at ≥ 34 weeks gestational age
    Subhankar Dasgupta
    Department of Obstetrics and Gynecology, Bankura Sammilani Medical College, Bankura, India
    J Obstet Gynaecol Res 38:763-71. 2012
    ..of this study was to evaluate whether prophylactic magnesium sulfate given in women with mild preeclampsia or gestational hypertension brings any significant change in umbilical artery and fetal middle cerebral artery pulsatility index.
  11. ncbi Expression of transforming growth factor-beta1, 2, 3 isoforms and type I and II receptors in acute focal cerebral ischemia: an immunohistochemical study in rat after transient and permanent occlusion of middle cerebral artery
    K A Ata
    Department of Genetics and Pathology, University Hospital, Uppsala, Sweden
    Acta Neuropathol 97:447-55. 1999
    ..type I and II in a rat model of focal brain ischemia induced by transient or permanent occlusion of the middle cerebral artery. Our findings indicate that at days 1 and 3 following such transient and permanent ischemia there is an up-..
  12. ncbi Optimal values of flow velocity on transcranial Doppler in grading middle cerebral artery stenosis in comparison with magnetic resonance angiography
    Shan Gao
    Department of Medicine and Therapeutics, Chinese University of Hong Kong, Shatin, Hong Kong, China
    J Neuroimaging 12:213-8. 2002
    To investigate the optimal values of flow velocity on transcranial Doppler (TCD) in grading the severity of middle cerebral artery (MCA) stenosis in comparison with magnetic resonance angiography (MRA).
  13. doi Resection of the nerves bundle from the sphenopalatine ganglia tend to increase the infarction volume following middle cerebral artery occlusion
    Su Diansan
    Department of Anesthesiology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, 1630 Dong Fang Road, 200127, Shanghai, China
    Neurol Sci 31:431-5. 2010
    ..the effects of resection of the nerves bundle from the SPG of rat on the brain lesions following middle cerebral artery occlusion (MCAO), and evaluated the roles of the nitric oxygen synthase (NOS) immunoreactive perivascular ..
  14. ncbi Microneurosurgical management of middle cerebral artery bifurcation aneurysms
    Reza Dashti
    Department of Neurosurgery, Helsinki University Central Hospital, 00260 Helsinki, Finland
    Surg Neurol 67:441-56. 2007
    ..The purpose of this article is to review the practical anatomy, preoperative planning, and avoidance of complications in the microsurgical dissection and clipping of MbifAs...
  15. doi Optimal brain perfusion CT coverage in patients with acute middle cerebral artery stroke
    A D Furtado
    Department of Radiology, University of California, San Francisco, 94143 0628, USA
    AJNR Am J Neuroradiol 31:691-5. 2010
    ....
  16. ncbi The influence of hyperoxia on regional cerebral blood flow (rCBF), regional cerebral blood volume (rCBV) and cerebral blood flow velocity in the middle cerebral artery (CBFVMCA) in human volunteers
    Christian Kolbitsch
    Department of Anaesthesia and Intensive Care Medicine, University of Innsbruck, Innsbruck, Austria
    Magn Reson Imaging 20:535-41. 2002
    ..20 volunteers for transcranial Doppler sonography (TCD) measurement of cerebral blood flow velocity in the middle cerebral artery (CBFV(MCA)). When compared to normoxia (FiO2 = 0.21), hyperoxia heterogeneously influenced rCBV (4...
  17. pmc Fenofibrate improves cerebral blood flow after middle cerebral artery occlusion in mice
    Qingmin Guo
    Department of Neurobiology, Neuroscience Institute, Morehouse School of Medicine, Atlanta, Georgia 30310, USA
    J Cereb Blood Flow Metab 30:70-8. 2010
    ..Animals were treated for 7 days with fenofibrate and subjected to 2 h of filamentous middle cerebral artery occlusion and reperfusion under isoflurane anesthesia...
  18. ncbi Early recanalization rates and clinical outcomes in patients with tandem internal carotid artery/middle cerebral artery occlusion and isolated middle cerebral artery occlusion
    Yo Sik Kim
    Department of Neurology, Wonkwang University, School of Medicine, Iksan, South Korea
    Stroke 36:869-71. 2005
    Patients with isolated middle cerebral artery (MCA) and tandem MCA/internal carotid artery (ICA) obstruction have similar presenting symptoms and stroke severity...
  19. pmc Development of a middle cerebral artery occlusion model in the nonhuman primate and a safety study of i.v. infusion of human mesenchymal stem cells
    Masanori Sasaki
    Department of Neurology, Yale University School of Medicine, New Haven, Connecticut, United States of America
    PLoS ONE 6:e26577. 2011
    ..The authors developed a surgical method for transient occlusion of the M1 branch of middle cerebral artery (MCA) in the African green monkey to evaluate safety aspects of intravenous infusion of mesenchymal stem ..
  20. doi Temporary stenting and retrieval of the self-expandable, intracranial stent in acute middle cerebral artery occlusion
    Sang Hyun Suh
    Department of Radiology, Gangnam Severance Hospital, Yonsei University College of Medicine, 146 92 Dogok dong Gangnam gu, Seoul, 135 720, Republic of Korea
    Neuroradiology 51:541-4. 2009
    ..our experience in which a retrievable Enterprise stent was used as a temporary recanalization and embolectomy device in an acute middle cerebral artery (MCA) occlusion after urgent stenting for ipsilateral carotid artery stenosis.
  21. ncbi Wogonin inhibits ischemic brain injury in a rat model of permanent middle cerebral artery occlusion
    Jungsook Cho
    Department of Pharmacology, College of Medicine, Dongguk University, Gyeongju, Gyeongbuk, Korea
    Biol Pharm Bull 27:1561-4. 2004
    ..Focal brain ischemia was induced by the permanent occlusion of middle cerebral artery (pMCAO) for 24 h with a silicone rubber cylinder inserted through the right internal carotid artery...
  22. pmc Pannexin protein expression in the rat middle cerebral artery
    Alan R Burns
    College of Optometry, University of Houston, Houston, Tex, USA
    J Vasc Res 49:101-10. 2012
    ..Pannexins are a recently discovered family of proteins that could potentially be involved in cell-to-cell communication. Herein, we sought to determine whether pannexins are expressed in rat middle cerebral artery (MCA).
  23. ncbi Role of estrogen in modulating EDHF-mediated dilations in the female rat middle cerebral artery
    E M Golding
    Department of Anesthesiology, Baylor College of Medicine, Houston, Texas 77030, USA
    Am J Physiol Heart Circ Physiol 280:H2417-23. 2001
    ..Our findings indicate that EDHF-mediated dilations are negligible in the female rat MCA; these dilations can be significantly enhanced after ovariectomy, suggesting that this effect is mediated by estrogen...
  24. pmc 2,2,2-trichloroethanol activates a nonclassical potassium channel in cerebrovascular smooth muscle and dilates the middle cerebral artery
    Nikhil K Parelkar
    Basic Medical Science Department, University of Missouri Kansas City School of Medicine, 2464 Charlotte St, HSB 2232, Kansas City, MO 64108, USA
    J Pharmacol Exp Ther 332:803-10. 2010
    ..Stimulation of K(+) channels such as TRAAK in cerebral arteries may therefore explain in part how CH/TCE increases CBF...
  25. ncbi Surgical strategies using cerebral revascularization in complex middle cerebral artery aneurysms
    Bo Ra Seo
    Department of Neurosurgery, Chonnam National University Hospital and Medical School, Gwangju, Republic of Korea
    Clin Neurol Neurosurg 111:670-5. 2009
    To describe surgical strategies using cerebral revascularization for complex middle cerebral artery aneurysms unsuitable to microsurgical clipping.
  26. ncbi Treatment of a middle cerebral artery bifurcation aneurysm using a double neuroform stent "Y" configuration and coil embolization: technical case report
    Sepehr Sani
    Department of Neurosurgery, Rush University Medical Center, Chicago, Illinois 60612, USA
    Neurosurgery 57:E209; discussion E209. 2005
    ..Despite this advancement, some parent vessel bifurcation aneurysms can still remain elusive to single stent and coiling technique...
  27. ncbi Temporary neurologic deterioration due to cerebral hyperperfusion after superficial temporal artery-middle cerebral artery anastomosis in patients with adult-onset moyamoya disease
    Miki Fujimura
    Department of Neurosurgery, Tohoku University School of Medicine, Sendai 980 8574, Japan
    Surg Neurol 67:273-82. 2007
    ..Surgical revascularization for moyamoya disease prevents cerebral ischemic attacks by improving CBF, but little is known about the change in CBF and its effect on neurologic status during the acute stage after revascularization...
  28. pmc Formation and maturation of the native cerebral collateral circulation
    Dan Chalothorn
    Department of Cell and Molecular Physiology, University of North Carolina, Chapel Hill, NC, USA
    J Mol Cell Cardiol 49:251-9. 2010
    ..These findings demonstrate that collaterals form late during vascular development and undergo postnatal maturation and that differences in genetic background have dramatic effects on these processes...
  29. doi Endovascular treatment of 174 middle cerebral artery aneurysms: clinical outcome and radiologic results at long-term follow-up
    Jean François Vendrell
    Department of Neuroradiology, University Hospital Center, Gui de Chauliac Hospital, 80 avenue Augustin Fliche, 34295 Montpellier Cedex 5, France
    Radiology 253:191-8. 2009
    To retrospectively evaluate the immediate safety and efficacy as well as the clinical outcome and long-term angiographic results of endovascular treatment (EVT) of middle cerebral artery (MCA) aneurysms.
  30. ncbi A novel rodent model of reperfusion injury following occlusion of the middle cerebral artery
    Barry J Connell
    Dept of Biomedical Sciences, Atlantic Veterinary College, University of Prince Edward Island, 550 University Ave, Charlottetown, PEI, Canada
    J Neurosci Methods 190:28-33. 2010
    ..In this model, blood flow through the middle cerebral artery (MCA) is temporarily occluded by placing gentle pressure on sutures behind the artery along three separate ..
  31. doi Recanalization of an acute middle cerebral artery occlusion using a self-expanding, reconstrainable, intracranial microstent as a temporary endovascular bypass
    Michael E Kelly
    Division of Cerebrovascular and Endovascular Neurosurgery, Department of Neurosurgery, Cleveland Clinic, S80, Cleveland, OH 44195, USA
    Stroke 39:1770-3. 2008
    Although self-expanding intracranial microstents have been used to treat acute middle cerebral artery (MCA) stroke, there are disadvantages associated with placing a permanent endovascular implant...
  32. ncbi Relationship between middle cerebral artery blood velocity and end-tidal PCO2 in the hypocapnic-hypercapnic range in humans
    Kojiro Ide
    Departments of Physiology and Biophysics, Faculty of Medicine, Heritage Medical Research Bldg Rm 212, University of Calgary, Calgary, Alberta, Canada
    J Appl Physiol (1985) 95:129-37. 2003
    ..We used transcranial Doppler ultrasound to determine middle cerebral artery peak blood velocity responses to 14 levels of PETCO2 in a range of 22 to 50 Torr with a constant end-tidal ..
  33. ncbi Stroke recurrences in patients with symptomatic vs asymptomatic middle cerebral artery disease
    R Kern
    Department of Neurology, Universitatsklinikum Mannheim, University of Heidelberg, 68135 Mannheim, Germany
    Neurology 65:859-64. 2005
    Although the natural history of extracranial carotid artery disease has been investigated systematically, limited data are available on the course of middle cerebral artery (MCA) disease.
  34. ncbi Accumulation of calpain and caspase-3 proteolytic fragments of brain-derived alphaII-spectrin in cerebral spinal fluid after middle cerebral artery occlusion in rats
    Brian R Pike
    Department of Neuroscience, Center for Traumatic Brain Injury Studies, E F and W L McKnight Brain Institute of the University of Florida, Gainesville, Florida, USA
    J Cereb Blood Flow Metab 24:98-106. 2004
    ..cerebrospinal fluid (CSF) of rodents subjected to 2 hours of transient focal cerebral ischemia produced by middle cerebral artery occlusion (MCAO) followed by reperfusion...
  35. ncbi Alterations in cerebral dynamics at high altitude following partial acclimatization in humans: wakefulness and sleep
    Philip N Ainslie
    Dept of Physiology, Univ of Otago, Dunedin, New Zealand
    J Appl Physiol (1985) 102:658-64. 2007
    ..We measured middle cerebral artery blood flow velocity (MCAv; transcranial Doppler ultrasound) and arterial blood pressure during wakefulness ..
  36. ncbi Differential effects of acute hypoxia and high altitude on cerebral blood flow velocity and dynamic cerebral autoregulation: alterations with hyperoxia
    Philip N Ainslie
    Dept of Physiology, Univ of Otago, Dunedin, New Zealand
    J Appl Physiol (1985) 104:490-8. 2008
    ..and 3) hyperoxia at HA and would have more influence on blood pressure (BP) and less influence on middle cerebral artery blood flow velocity (MCAv)...
  37. pmc Elective stenting for symptomatic middle cerebral artery stenosis presenting as transient ischaemic deficits or stroke attacks: short term arteriographical and clinical outcome
    J K Kim
    Graduate School of Life Science and Biotechnology, Pundang CHA Hospital, College of Medicine, Pochon CHA University, 351 Yatapdong, Pundangku, Sungnam 463 712, Korea
    J Neurol Neurosurg Psychiatry 75:847-51. 2004
    ..Although stent assisted angioplasty is an effective treatment for coronary and peripheral arterial disease, its efficacy in intracranial arteriosclerotic disease has not been verified...
  38. ncbi Lesion patterns and stroke mechanism in atherosclerotic middle cerebral artery disease: early diffusion-weighted imaging study
    Dae K Lee
    Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 138 736, Korea
    Stroke 36:2583-8. 2005
    Patterns and mechanisms of stroke in patients with atherosclerotic middle cerebral artery (MCA) disease remain unclear...
  39. ncbi Cerebral lateralization and general intelligence: gender differences in a transcranial Doppler study
    Philip C Njemanze
    Non invasive Neurocybernetic Flow Laboratory, International Institutes of Advanced Research and Training, Chidicon Medical Center, Owerri, Imo State, Nigeria
    Brain Lang 92:234-9. 2005
    ..This implies that general intelligence is associated with neural systems within one hemisphere that are accessible to a variety of cognitive processes...
  40. ncbi Gene expression profiling in the human middle cerebral artery after cerebral ischemia
    P Vikman
    Department of Experimental Vascular Research, Institution of Medicine, Lund University, Lund, Sweden
    Eur J Neurol 13:1324-32. 2006
    We have investigated the gene expression in human middle cerebral artery (MCA) after ischemia...
  41. pmc SKCa and IKCa Channels, myogenic tone, and vasodilator responses in middle cerebral arteries and parenchymal arterioles: effect of ischemia and reperfusion
    Marilyn J Cipolla
    Department of Neurology, University of Vermont, Burlington, VT 05405, USA
    Stroke 40:1451-7. 2009
    ....
  42. doi Embryonic neural stem cells transplanted in middle cerebral artery occlusion model of rats demonstrated potent therapeutic effects, compared to adult neural stem cells
    Kazuya Takahashi
    Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama, 700 8558, Japan
    Brain Res 1234:172-82. 2008
    ..In this study, we explored the therapeutic effects of neural progenitor cells (NPC) upon middle cerebral artery occlusion (MCAO) model of rats with exploration of the differences between adult and embryonic NPCs in ..
  43. ncbi Subarachnoid hemorrhage enhances endothelin receptor expression and function in rat cerebral arteries
    Jacob Hansen-Schwartz
    Department of Internal Medicine, Lund University Hospital, Lund, Sweden
    Neurosurgery 52:1188-94; 1194-5. 2003
    ..Inspired by organ culture-induced changes in the vascular endothelin (ET) receptor population, we investigated whether such changes occur in cerebral arteries in a rat subarachnoid hemorrhage (SAH) model...
  44. ncbi NO synthase blockade induces chaotic cerebral vasomotion via activation of thromboxane receptors
    Z Lacza
    Department of Physiology, Ludwig-Maximilians University, Munich, Germany
    Stroke 32:2609-14. 2001
    ..The vasomotion after blockade of the NO-cGMP pathway is mediated by activation of thromboxane receptors...
  45. ncbi Effects of hypobaric hypoxia on cerebral autoregulation
    Andrew W Subudhi
    Altitude Research Center, University of Colorado at Denver, School of Medicine, Denver, CO, USA
    Stroke 41:641-6. 2010
    ..This investigation evaluated relationship between CA and AMS over 9 hours of hypobaric hypoxia...
  46. doi Acute ischemic infarct in the middle cerebral artery territory following a Russell's viper bite
    Sanjeev K Narang
    Department of General Medicine, Mamata General Hospital, Mamata Medical College, Khammam, Andhra Pradesh, India
    Neurol India 57:479-80. 2009
    ..T2-weighted magnetic resonance imaging revealed infarct in the left middle cerebral artery territory...
  47. ncbi Comparison of silicon-coated nylon suture to plain nylon suture in the rat middle cerebral artery occlusion model
    Norihito Shimamura
    Department of Physiology and Pharmacology, Loma Linda University School of Medicine, Loma Linda, CA 92350, USA
    J Neurosci Methods 156:161-5. 2006
    A variety of intraluminal sutures have been used in the middle cerebral artery occlusion model (MCAO) of focal ischemia...
  48. doi Outcome for middle cerebral artery aneurysm surgery
    Michael K Morgan
    Australian School of Advanced Medicine, Level 1, 3 Dow Corning, Innovation Rd, Macquarie University, NSW 2109, Australia
    Neurosurgery 67:755-61; discussion 761. 2010
    To assess in depth the variables contributing to adverse surgical outcome for repair of unruptured middle cerebral artery aneurysms.
  49. ncbi Mechanisms of acute cerebral infarctions in patients with middle cerebral artery stenosis: a diffusion-weighted imaging and microemboli monitoring study
    Ka Sing Wong
    Department of Medicine and Therapeutics, Chinese University of Hong Kong, Shatin, Hong Kong, SAR
    Ann Neurol 52:74-81. 2002
    ..most therapeutic efforts and experimental stroke models focus on the concept of complete occlusion of the middle cerebral artery as a result of embolism from the carotid artery or cardiac chamber, relatively little is known about the ..
  50. ncbi Microglia and macrophages express tumor necrosis factor receptor p75 following middle cerebral artery occlusion in mice
    K L Lambertsen
    Medical Biotechnology Center, Winsloewparken 25, University of Southern Denmark, Odense, DK 5000, Denmark
    Neuroscience 144:934-49. 2007
    ..of the TNF receptors, TNF-p55R and TNF-p75R, from 1 to 10 days following permanent occlusion of the middle cerebral artery in mice...
  51. ncbi Collateral growth and angiogenesis around cortical stroke
    L Wei
    Department of Neurology, Washington University School of Medicine, St Louis, MO, USA
    Stroke 32:2179-84. 2001
    ..We tested the hypothesis that there are significant long-term local vascular changes after ministroke that could form a basis for functional recovery...
  52. doi Clinical applications of susceptibility weighted imaging in patients with major stroke
    Poyin Huang
    Department of Neurology, Kaohsiung Medical University, Kaohsiung, Taiwan
    J Neurol 259:1426-32. 2012
    ..We conducted a prospective study of patients hospitalized with middle cerebral artery territory infarction receiving MRI within 2 days of stroke onset...
  53. ncbi Focal hyperperfusion after superficial temporal artery-middle cerebral artery anastomosis in a patient with moyamoya disease. Case report
    Kazuhide Furuya
    Department of Neurosurgery, University of Tokyo Hospital, Tokyo, Japan
    J Neurosurg 100:128-32. 2004
    Superficial temporal artery-middle cerebral artery (STA-MCA) anastomosis is a standard surgical therapeutic option in patients with moyamoya disease...
  54. ncbi Effects of caffeic acid phenethyl ester on cerebral cortex: structural changes resulting from middle cerebral artery ischemia reperfusion
    N Cengiz
    Department of Histology, Faculty of Medicine Yuzuncu Yil, University Van, Turkey
    Clin Neuropathol 26:80-4. 2007
    ..The middle cerebral artery was occluded for 60 min with an intraluminal suture, followed by 24-h reperfusion...
  55. ncbi Probabilistic anatomic mapping of cerebral blood flow distribution of the middle cerebral artery
    Seong Jang Kim
    Department of Nuclear Medicine, Pusan National University Hospital, Busan, Republic of Korea
    J Nucl Med 49:39-43. 2008
    ..They allow anatomic and functional labeling of the results of group studies in stereotactic space and, hence, the automated anatomic labeling of individual brain imaging data...
  56. ncbi Symptomatic hyperperfusion after superficial temporal artery-middle cerebral artery anastomosis in a child with moyamoya disease
    Miki Fujimura
    Department of Neurosurgery, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 980 8574, Japan
    Childs Nerv Syst 23:1195-8. 2007
    ..Surgical revascularization for moyamoya disease prevents cerebral ischemic attacks by improving cerebral blood flow (CBF). It is undetermined, however, how rapid increase in CBF affects ischemic brain at acute stage, especially in children...
  57. doi Atherosclerosis of middle cerebral artery: evaluation with high-resolution MR imaging at 3T
    Ming li Li
    Department of Radiology, Peking Union Medical College Hospital and Chinese Academy of Medical Science, Shuai Fu Yuan 1, Dong Cheng District, Beijing 100730, China
    Atherosclerosis 204:447-52. 2009
    ..The aim of this study was to assess whether high resolution cross sectional magnetic resonance imaging (HRMRI) could compensate the limitation of 3D TOF MRA in the atherosclerotic disease of middle cerebral artery (MCA).
  58. ncbi Pure vasogenic edema caused by cerebral hyperperfusion after superficial temporal artery to middle cerebral artery anastomosis--case report
    Jouji Kokuzawa
    Department of Neurosurgery, Asahi University Murakami Memorial Hospital, Gifu, Japan
    Neurol Med Chir (Tokyo) 50:250-3. 2010
    ..as transient aphasia and general tonic convulsions 3 and 4 days after superficial temporal artery to middle cerebral artery (STA-MCA) anastomosis...
  59. ncbi Fenestration of the middle cerebral artery detected by MR angiography
    Akira Uchino
    Department of Radiology, Saga Medical School, Nabeshima, Saga, Japan
    Magn Reson Med Sci 5:51-5. 2006
    ..We investigated the location and configuration of fenestration of the middle cerebral artery (MCA) detected by magnetic resonance (MR) angiography...
  60. pmc Surgical clipping as the preferred treatment for aneurysms of the middle cerebral artery
    J Marc C van Dijk
    Department of Neurosurgery, University Medical Center Groningen, University of Groningen, The Netherlands
    Acta Neurochir (Wien) 153:2111-7. 2011
    ..Despite the fact that in ISAT middle cerebral artery (MCA) aneurysms were clearly underrepresented, the study is often used as an argument to favor coiling ..
  61. ncbi Biofeedback-assisted relaxation in migraine headache: relationship to cerebral blood flow velocity in the middle cerebral artery
    Sachinder Vasudeva
    Departments of Psychiatry, Medical College of Ohio, Toledo, Spain
    Headache 43:245-50. 2003
    ..Background.-The relationship between cerebral blood flow velocity and treatment response to biofeedback/relaxation in migraine with and without aura is uncertain...
  62. ncbi Progression of middle cerebral artery susceptibility sign on T2*-weighted images: its effect on recanalization and clinical outcome after thrombolysis
    Ho Sung Kim
    Department of Radiology, Division of Neuroradiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, 388 1 Poongnap dong, Songpa Gu, Seoul 138 736, South Korea
    AJR Am J Roentgenol 187:W650-7. 2006
    The middle cerebral artery (MCA) "susceptibility sign" on T2*-weighted imaging has been reported to indicate acute thrombotic occlusion...
  63. doi Effects of intracerebroventricular galanin or a galanin receptor 2/3 agonist on the lesion induced by transient occlusion of the middle cerebral artery in female rats
    Lovisa Holm
    Department of Clinical and Experimental Medicine Division of Clinical Chemistry, Linkoping University, Linkoping, Sweden
    Neuropeptides 45:17-23. 2011
    ..c.v.) in naïve female rats after a 60min transient and focal occlusion of the middle cerebral artery. The animals were sacrificed, and the ischemic lesion was visualized using 2,3,5-triphenyltetrazolium ..
  64. ncbi Blocking pterygopalatine arterial blood flow decreases infarct volume variability in a mouse model of intraluminal suture middle cerebral artery occlusion
    Yili Chen
    Department of Neurosurgery, Faculty of Medicine, University of Tokyo, Tokyo 113 8655, Japan
    J Neurosci Methods 174:18-24. 2008
    The mouse model of intraluminal suture middle cerebral artery occlusion (MCAO) is still associated with several issues, such as variability of infarction volume and survival. Thus, the method is far from standardization...
  65. doi Superficial temporal artery-middle cerebral artery bypass surgery in a pediatric giant intracranial aneurysm presenting as migraine-like episodes
    H S Goedee
    Department of Neurology, Elisabeth Hospital Tilburg, Tilburg, The Netherlands
    Childs Nerv Syst 25:257-61. 2009
    ..Aneurysms of the intracranial arteries in the pediatric population are reportedly rare. There is a male predominance, association with connective tissue disorders, as well as bacterial, mycotic infections, and trauma...
  66. doi Effect of permanent middle cerebral artery occlusion on Cytoglobin expression in the mouse brain
    Zindy Raida
    Department of Neuroscience and Pharmacology, The Panum Institute, University of Copenhagen, Copenhagen, Denmark
    Biochem Biophys Res Commun 424:274-8. 2012
    ..Ten were sham operated and ten were given permanent middle cerebral artery occlusion (pMCAo). All animals were euthanized after 24h...
  67. ncbi Middle cerebral artery peak systolic velocity for the diagnosis of fetal anemia: the untold story
    G Mari
    Department of Obstetrics and Gynecology, Wayne State University, Perinatology Research Branch, NICHD, NIH, DHHS, Detroit, MI, USA
    Ultrasound Obstet Gynecol 25:323-30. 2005
  68. pmc Rapid identification of a major diffusion/perfusion mismatch in distal internal carotid artery or middle cerebral artery ischemic stroke
    Reza Hakimelahi
    Neuroradiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    BMC Neurol 12:132. 2012
    ..the hypothesis that in patients with occlusion of the terminal internal carotid artery and/or the proximal middle cerebral artery, a diffusion abnormality of 70 ml or less is accompanied by a diffusion/perfusion mismatch of at least 100%...
  69. ncbi Tandem internal carotid artery/middle cerebral artery occlusion: an independent predictor of poor outcome after systemic thrombolysis
    Marta Rubiera
    Brain Hemodynamics Lab, Stroke Unit, Department of Neurology, Hospital Vall d Hebron, Passeig Vall d Hebron 119 129, 08035 Barcelona, Spain
    Stroke 37:2301-5. 2006
    Although tandem internal carotid artery/middle cerebral artery (MCA; TIM) occlusion has been associated with low recanalization rate after IV tissue plasminogen activator (tPA), its independent contribution on stroke outcome remains ..
  70. pmc Regulation of middle cerebral artery blood velocity during dynamic exercise in humans: influence of aging
    James P Fisher
    Department of Medical Pharmacology and Physiology, University of Missouri, Columbia, MO 65212, USA
    J Appl Physiol (1985) 105:266-73. 2008
    ..Therefore, to address this question, middle cerebral artery blood velocity (MCAV), mean arterial pressure (MAP), and the partial pressure of arterial carbon dioxide (..
  71. doi Minimally invasive superficial temporal artery to middle cerebral artery bypass through a minicraniotomy: benefit of three-dimensional virtual reality planning using magnetic resonance angiography
    Gerrit Fischer
    Neurochirurgische Klinik und Poliklinik, Universitaetsmedizin, Johannes Gutenberg Universitaet, Mainz, Germany
    Neurosurg Focus 26:E20. 2009
    The aim of the authors in this study was to introduce a minimally invasive superficial temporal artery to middle cerebral artery (STA-MCA) bypass surgery by the preselection of appropriate donor and recipient branches in a 3D virtual ..
  72. ncbi Accuracy of perfusion-CT in predicting malignant middle cerebral artery brain infarction
    R Dittrich
    Dept of Neurology, University Hospital of Muenster, Albert Schweitzer Strasse 33, 48129 Muenster, Germany
    J Neurol 255:896-902. 2008
    We performed a prospective study on patients with middle cerebral artery(MCA) ischemic stroke to evaluate the accuracy of perfusion-CT imaging(PCT) to predict the development of malignant brain infarction (MBI).
  73. ncbi Effects of anti-intercellular adhesion molecule-1 antibody on reperfusion injury induced by late reperfusion in the rat middle cerebral artery occlusion model
    Yukihide Kanemoto
    Department of Neurosurgery, Nara Medical University, Kashihara City, Japan
    Neurosurgery 51:1034-41; discussion 1041-2. 2002
    ..The aim of the present study was to assess the effects of an anti-ICAM-1 antibody on reperfusion-induced injury after late reperfusion in a rat middle cerebral artery occlusion (MCAO) suture model.
  74. ncbi Transient middle cerebral artery occlusion in rats as an experimental model of brain ischemia
    Renato Luis Calloni
    Department of Clinical Surgery, UCS, Caxias do Sul, Brazil
    Acta Cir Bras 25:428-33. 2010
    To assess a rat model of cerebral ischemia induced by occlusion of the middle cerebral artery and its effect on the area of cerebral infarction.
  75. ncbi Middle cerebral artery Doppler in fetuses with transposition of the great arteries
    J M Jouannic
    Maternité, Hopital Necker Enfants Malades, AP HP Université Paris V, Paris
    Ultrasound Obstet Gynecol 20:122-4. 2002
    ..The aim of this study was to compare Doppler blood flow velocity waveforms in fetuses with transposition of the great arteries with those in healthy fetuses...
  76. ncbi Effect of early and delayed recanalization on infarct pattern in proximal middle cerebral artery occlusion
    Marek Humpich
    Department of Neurology, J W Goethe University, Frankfurt am Main, Germany
    Cerebrovasc Dis 22:51-6. 2006
    To investigate the effect of early (<6 h) versus delayed (>6 h) recanalization on infarct pattern in acute middle cerebral artery (MCA) occlusion.
  77. doi Third trimester fetal heart rate and Doppler middle cerebral artery blood flow velocity characteristics during prenatal selective serotonin reuptake inhibitor exposure
    Dan Rurak
    Department of Obstetrics and Gynecology, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada
    Pediatr Res 70:96-101. 2011
    ..Fetal middle cerebral artery (MCA) flow parameters and heart rate characteristics were obtained during pre-SSRI dose morning and ..
  78. ncbi Middle cerebral artery peak systolic and ductus venosus velocity waveforms in the hydropic fetus
    Erich Cosmi
    Department of Gynecological Science and Reproductive Medicine, University of Padua School of Medicine, Via Giustiniani 3, 35100 Padua, Italy
    J Ultrasound Med 24:209-13. 2005
    The purpose of this study was to assess whether Doppler assessment of the middle cerebral artery (MCA) peak systolic velocity (PSV) and ductus venosus (DV) velocity waveforms during sonography of hydropic fetuses may specify the cause of ..
  79. ncbi Proximal superficial temporal artery to proximal middle cerebral artery bypass using a radial artery graft: an anatomic approach
    Mustafa Buyukmumcu
    Department of Anatomy, Meram Faculty of Medicine, Selcuk University, 42080, Konya, Turkey
    Neurosurg Rev 27:185-8. 2004
    ..the use of radial artery graft for bypass of the proximal superficial temporal artery to the proximal middle cerebral artery. Six adult cadaver sites were used bilaterally...
  80. pmc Autoregulation in the posterior circulation is altered by the metabolic state of the visual cortex
    Kazuma Nakagawa
    Department of Neurology, Stroke Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Stroke 40:2062-7. 2009
    ..that dynamic autoregulation in the posterior cerebral artery (PCA) is less efficient compared to the middle cerebral artery (MCA)...
  81. ncbi Magnetic resonance angiography shows dilatation of the middle cerebral artery after infusion of glyceryl trinitrate in healthy volunteers
    J M Hansen
    Danish Headache Centre, Department of Neurology, Glostrup Hospital, University of Copenhagen, Copenhagen, Denmark
    Cephalalgia 27:118-27. 2007
    Previous studies have reported dilatation of the middle cerebral artery (MCA) during acute glyceryl trinitrate (GTN)-induced headache, using imaging techniques such as transcranial Doppler (TCD), positron emission tomography (PET) and ..
  82. ncbi Effect of magnesium, high altitude and acute mountain sickness on blood flow velocity in the middle cerebral artery
    Christopher Lysakowski
    Neuroanaesthesia Unit, Division of Anaesthesiology, Department of Anaesthesiology, Pharmacology and Surgical Intensive Care, Geneva University Hospitals, Geneva, Switzerland
    Clin Sci (Lond) 106:279-85. 2004
    ..Blood flow velocity in the middle cerebral artery (MCAv) may be used as a proxy measure of cerebral blood flow...
  83. ncbi Intravenous basic fibroblast growth factor produces a persistent reduction in infarct volume following permanent focal ischemia in rats
    H Sugimori
    CNS Growth Factor Research Laboratory, Warren 408, Massachusetts General Hospital, Boston, MA 02114, USA
    Neurosci Lett 300:13-6. 2001
    ..5-3.5h after permanent proximal middle cerebral artery occlusion...
  84. ncbi Middle cerebral artery flow velocity and pulse pressure during dynamic exercise in humans
    Shigehiko Ogoh
    Dept of Integrative Physiology, University of North Texas Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX 76107, USA
    Am J Physiol Heart Circ Physiol 288:H1526-31. 2005
    ..and mean (V(m)) middle cerebral artery (MCA) blood flow velocity during mild, moderate, and heavy cycling exercise...
  85. ncbi Middle cerebral artery peak systolic velocity: a new Doppler parameter in the assessment of growth-restricted fetuses
    G Mari
    Department of Obstetrics and Gynecology, Wayne State University, Detroit, MI 48201, USA
    Ultrasound Obstet Gynecol 29:310-6. 2007
    The aims of this study were to determine if there is a relationship between middle cerebral artery (MCA) peak systolic velocity (PSV) and perinatal mortality in preterm intrauterine growth-restricted (IUGR) fetuses, to compare the ..
  86. pmc Differential responses to CO2 and sympathetic stimulation in the cerebral and femoral circulations in humans
    Philip N Ainslie
    Department of Physiology and Biophysics, Faculty of Medicine, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta T2N 4N1, Canada
    J Physiol 566:613-24. 2005
    ..1 +/- 3.7 (mean +/- S.D.) years), we measured flow velocity (VP; transcranial Doppler ultrasound) in the middle cerebral artery during euoxic isocapnia (ISO, +1 mmHg above rest) and two levels of euoxic hypercapnia (HC5, end-tidal P(..
  87. ncbi Imaging of brain hypoxia in permanent and temporary middle cerebral artery occlusion in the rat using 18F-fluoromisonidazole and positron emission tomography: a pilot study
    Masashi Takasawa
    Stroke Research Group, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK
    J Cereb Blood Flow Metab 27:679-89. 2007
    ..In the only validation study of 18F-FMISO, using ex vivo autoradiography in thread middle cerebral artery occluded (MCAo) rats, there was unexpected high uptake as late as 22 h after reperfusion, raising ..
  88. ncbi Neuroprotective effect of Acorus calamus against middle cerebral artery occlusion-induced ischaemia in rat
    Pradeep K Shukla
    Industrial Toxicology Research Centre, PO Box 80, M G Marg, Lucknow 226001, India
    Hum Exp Toxicol 25:187-94. 2006
    ..potential of ethanol:water (1:1) extract of rhizomes of Acorus calamus (AC-002) has been investigated in middle cerebral artery occlusion (MCAO)-induced ischaemia in rats...
  89. ncbi [Large kissing aneurysms of the middle cerebral artery: a case report--classification of kissing aneurysms]
    Katsumi Harada
    Department of Neurosurgery, Shuto General Hospital, Yanai, Yamaguchi, Japan
    No Shinkei Geka 32:513-7. 2004
    We report a rare case of kissing aneurysms located at the middle cerebral artery. A 69-year-old man had a severe subarachnoid hemorrhage associated with intracerebral hematoma (Hunt and Hess grade 5, WFNS grade V)...
  90. ncbi Cerebral vasoreactivity in Andeans and headache at sea level
    O Appenzeller
    NMHEMC Research Foundation, Otto Appenzeller, 361, Big Horn Ridge Drive NE, Albuquerque, NM 87122 1424, USA
    J Neurol Sci 219:101-6. 2004
    ..of isosorbite dinitrate (IDN), a nitric oxide (NO) donor, using transcranial Doppler ultrasound in the middle cerebral artery (MCA) in natives of CP, some of whom suffered from CMS...
  91. ncbi Cardiorespiratory and cerebrovascular responses to acute poikilocapnic hypoxia following intermittent and continuous exposure to hypoxia in humans
    Philip N Ainslie
    Dept of Physiology, University of Otago, Dunedin, New Zealand
    J Appl Physiol (1985) 102:1953-61. 2007
    ..12) in which ventilation, end-tidal gases, arterial O(2) saturation, BP, and middle cerebral artery blood flow velocity (MCAV) were measured continuously...
  92. ncbi Infarct patterns in atherosclerotic middle cerebral artery versus internal carotid artery disease
    P H Lee
    Department of Neurology, School of Medicine, Ajou University, Suwon, Korea
    Neurology 62:1291-6. 2004
    To compare clinical and radiologic characteristics of atherosclerotic middle cerebral artery (MCA) vs internal carotid artery (ICA) disease.
  93. ncbi Correlation between blood flow velocity in the middle cerebral artery and EEG during cognitive effort
    Imre Szirmai
    Department of Neurology, Semmelweis University Budapest, 1083 Budapest, Balassa u 6 Hungary
    Brain Res Cogn Brain Res 24:33-40. 2005
    Cognitive effort modifies blood flow velocity (BFV) in the middle cerebral artery (MCA) which can be recorded by transcranial Doppler sonography (TCD). EEG parameters can be used as indicators of cortical activation...
  94. ncbi Superficial temporal artery to middle cerebral artery bypass
    David W Newell
    Department of Neurological Surgery, University of Washington School of Medicine, Harborview Medical Center, Seattle, 98104, USA
    Neurosurgery 54:1441-8; discussion 1448-9. 2004
    The superficial temporal artery to middle cerebral artery bypass is an elegant procedure that was developed and first performed by M. Gazi Yaşargil...
  95. ncbi Assessment of middle cerebral artery diameter after aneurysmal subarachnoid hemorrhage by transcranial color-coded duplex sonography
    M Muller
    Department of Neurology, University Hospital of the Saarland, Kirrberger Strasse, D 66421, Homburg Saar, Germany
    Eur J Ultrasound 11:15-9. 2000
    This study examined if vasospasm after aneurysmal subarachnoid hemorrhage could be visualized by middle cerebral artery (MCA) diameter changes in transcranial color-coded duplex sonography (TCCS)...
  96. ncbi Pattern of cortex and white matter involvement in severe middle cerebral artery ischemia
    Maria Cornelia Stoeckel
    Department of Neurology, University Hospital Dusseldorf, Dusseldorf, Germany
    J Neuroimaging 17:131-40. 2007
    In middle cerebral artery (MCA) stroke, ischemia usually is unevenly distributed within the MCA territory. We sought to investigate which brain structures are critical for the acute neurological deficit in severe MCA stroke.
  97. doi Effects of 0.6 mg/kg intravenous alteplase on vascular and clinical outcomes in middle cerebral artery occlusion: Japan Alteplase Clinical Trial II (J-ACT II)
    Etsuro Mori
    Department of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Stroke 41:461-5. 2010
    ..6 mg/kg intravenous alteplase on vascular and clinical outcomes in patients with middle cerebral artery occlusion in a postmarketing Phase IV trial of prospective cohort study design.
  98. ncbi An intracranial pseudoaneurysm in the distal middle cerebral artery in a child
    Masaru Honda
    Department of Neurosurgery, Okinawa Nanbu Medical Center and Children s Medical Center, Haebaru, Japan
    Pediatr Neurosurg 44:426-9. 2008
    ..We here describe a patient with a large pseudoaneurysm arising in the distal middle cerebral artery. A 10-year-old boy experienced a sudden onset of headache, nausea, and vomiting followed by loss of ..
  99. ncbi Middle cerebral artery plaque imaging using 3-Tesla high-resolution MRI
    Kuniyasu Niizuma
    Department of Neurosurgery, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi, Sendai 980 8574, Japan
    J Clin Neurosci 15:1137-41. 2008
    Diagnosis of deep subcortical infarcts based on atherosclerosis of the middle cerebral artery (MCA) is important because this type of infarct is usually more aggressive than typical lacunar infarcts...
  100. doi Permanent middle cerebral artery occlusion in sheep: a novel large animal model of focal cerebral ischemia
    Johannes Boltze
    Fraunhofer Institute of Cell Therapy and Immunology, Leipzig, Germany
    J Cereb Blood Flow Metab 28:1951-64. 2008
    ..In this study, we are introducing a simple, but reliable stroke model using permanent middle cerebral artery occlusion in sheep...
  101. ncbi Influence of indomethacin on ventilatory and cerebrovascular responsiveness to CO2 and breathing stability: the influence of PCO2 gradients
    Jui Lin Fan
    Department of Physiology, Otago School of Medical Science, University of Otago, Dunedin, New Zealand
    Am J Physiol Regul Integr Comp Physiol 298:R1648-58. 2010
    ..We measured arterial blood gases, ventilation (VE), and middle cerebral artery velocity (MCAv) before and 90 min following INDO ingestion (100 mg) or placebo in 12 healthy participants...

Research Grants109 found, 100 shown here

  1. REGULATION OF BRAIN THROMBOSIS IN STROKE MODELS
    Berislav Zlokovic; Fiscal Year: 2003
    ..initially developed a mouse stroke model with fibrin-rich microvascular deposits and obstructions due to middle cerebral artery occlusion/reperfusion or thrombin-induced thromboembolism...
  2. Mechanisms of Endothelial Cell Hyperpolarization
    SEAN MARRELLI; Fiscal Year: 2009
    ..RT-PCR and immunohistochemistry), measure [Ca2+]i and Ca2+ influx in response to ATP in freshly isolated middle cerebral artery (MCA) ECs and in the ECs of pressurized MCA (Fura 2 dye), and demonstrate the role of the identified TRP ..
  3. Development of Potent/Selective Lipoxygenase Therapeutics Against Stroke Injury
    Theodore R Holman; Fiscal Year: 2013
    ..12/15-LOX expression is increased in the peri-infarct region following middle cerebral artery occlusion (MCAO) in mice, both in neurons and in endothelial cells, which contributes to ischemic brain ..
  4. US-China Collaborative Research on Stroke Imaging
    Jinyuan Zhou; Fiscal Year: 2013
    ..We will test our hypothesis on animals, using a clinically relevant middle cerebral artery occlusion model, and perform pilot human scanning on hyperacute and acute ischemic stroke patients to ..
  5. The Role of Astrocytic Transglutaminase 2 in Mediating Ischemic Stroke Damage
    JULIANNE M FEOLA; Fiscal Year: 2013
    ..under ischemic condition, and 3) astrocyte-specific knockout of TG2 will reduce the infarct volume after a middle cerebral artery ligation (MCAL) in vivo. For the first two aims, I will use cell culture models...
  6. BLOOD-BRAIN BARRIER ION TRANSPORT IN CEREBRAL ISCHEMIA
    MARTHA E O'DONNELL; Fiscal Year: 2013
    ..and vasopressin (AVP) and that inhibiting BBB NKCC and/or NHE activity reduces brain edema in the rat middle cerebral artery occlusion (MCAO) model of stroke...
  7. Neurorestorative therapy of stroke with HUCBC in T2DM rats
    Jieli Chen; Fiscal Year: 2013
    ..We found that treatment of stroke with HUCBCs starting at 1 or 3 days after middle cerebral artery occlusion (MCAo) improves recovery of neurological function in DM rats...
  8. Middle cerebral artery stroke: Non-contrast MR screening of high-risk plaque
    Chun Yuan; Fiscal Year: 2013
    ..phenomena arising from atherosclerotic plaque in large arteries supplying the brain through the Middle Cerebral Artery (MCA) are known to account for a quarter to one-third of ischemic MCA stroke despite being one of the most ..
  9. A Novel Adjunct to Physical Training to Improve Motor Recovery Following Stroke
    Michael P Kilgard; Fiscal Year: 2013
    ..To achieve our Specific Aim, we will carry out the following Task: Task 1: Using a rat model of middle cerebral artery occlusion (MCAo), evaluate recovery of function of upper limb motor deficits in three groups of rats: ..
  10. Delayed cognitive impairment after stroke
    Marion S Buckwalter; Fiscal Year: 2013
    ..In our model mice undergo DH stroke as a result of distal middle cerebral artery occlusion followed by hypoxia. This confers a primarily cortical infarct...
  11. TWEAK-Induced Neuroinflammation and Cerebral Edema
    MANUEL SALVADOR YEPES; Fiscal Year: 2011
    ..We have also found that following middle cerebral artery occlusion (MCAO) the expression of TWEAK and Fn14 increases in the ischemic area, and that inhibition of ..
  12. ANG II: Permissive role to maintain vascular relaxation
    JULIAN LOMBARD; Fiscal Year: 2007
    ..v. infusion of a low dose of angiotensin II (ANGII). This project will study the response of the middle cerebral artery (MCA) to vasodilator stimuli in four novel inbred genetic rat strains: 1) Dahl salt sensitive (Dahl S; SS/..
  13. ANG II: Permissive role to maintain vascular relaxation
    JULIAN LOMBARD; Fiscal Year: 2003
    ..v. infusion of a low dose of angiotensin II (ANGII). This project will study the response of the middle cerebral artery (MCA) to vasodilator stimuli in four novel inbred genetic rat strains: 1) Dahl salt sensitive (Dahl S; SS/..
  14. Cellular Mechanisms of Vasoregulation by Volatile Anesthetics
    Rostislav Bychkov; Fiscal Year: 2010
    ..Specific Aim 1: To determine pharmacology of blockers-resistive K2P-like currents in thoracic aorta and middle cerebral artery. In this aim, we propose to prove by pharmacological tools that blockers resistive whole cell outward ..
  15. Homing of Stem Cells in Stroke Therapeutics
    Evan Snyder; Fiscal Year: 2009
    ..Rats will be injected iv with the stem cells at 24-72 hrs post-middle cerebral artery occlusion...
  16. Homing of Stem Cells in Stroke Therapeutics
    EVAN YALE contact SNYDER; Fiscal Year: 2010
    ..Rats will be injected iv with the stem cells at 24-72 hrs post-middle cerebral artery occlusion...
  17. Deregulated lipid metabolism in stroke
    RAO M ADIBHATLA; Fiscal Year: 2010
    ..p21 and p27 through ceramide accumulation, and (c) attenuated Rb phosphorylation after transient middle cerebral artery occlusion (tMCAO) in rat. Our studies strongly support SMS inhibition by D609 leading to cell cycle arrest...
  18. HEMODYNAMICS OF CEREBRAL ARTERIOVENOUS MALFORMATIONS
    William Young; Fiscal Year: 1999
    ..Experiments will enrol a total of 80 AVM patients to study otherwise normal middle cerebral artery (MCA) territories rendered hypotensive by the AVM shunt flow and 40 non-AVM controls over 4 years...
  19. HEMODYNAMICS OF CEREBRAL ARTERIOVENOUS MALFORMATIONS
    William Young; Fiscal Year: 1999
    ..Experiments will enrol a total of 80 AVM patients to study otherwise normal middle cerebral artery (MCA) territories rendered hypotensive by the AVM shunt flow and 40 non-AVM controls over 4 years...
  20. MRI of Acute Vascular Injury and Hemorrhagic Transformation in Ischemic Stroke
    Robert A Knight; Fiscal Year: 2010
    ..Two rat middle cerebral artery (MCA) occlusion models, intraluminal filament and embolic, will be used...
  21. MRI of Acute Vascular Injury and Hemorrhagic Transformation in Ischemic Stroke
    Robert Knight; Fiscal Year: 2009
    ..Two rat middle cerebral artery (MCA) occlusion models, intraluminal filament and embolic, will be used...
  22. Hypothermia in Acute Stroke with Thrombolysis Imaging Evaluation of Revasculariza
    DAVID SIGMUND LIEBESKIND; Fiscal Year: 2013
    ..This prospective, ancillary study of 120 ICTuS 2 subjects with middle cerebral artery stroke over 2 years uses an innovative imaging approach with multimodal CT/MRI to seamlessly evaluate ..
  23. BLOOD-BRAIN BARRIER TRANSPORT AND ISCHEMIC BRAIN INJURY
    Richard Keep; Fiscal Year: 2002
    ..and p-[3H] aminohippuric acid (PAH, an organic acid transporter substrate) will be determined following middle cerebral artery occlusion in rat and mouse (Specific Aim 1)...
  24. BLOOD-BRAIN BARRIER TRANSPORT AND ISCHEMIC BRAIN INJURY
    Richard Keep; Fiscal Year: 2000
    ..and p-[3H] aminohippuric acid (PAH, an organic acid transporter substrate) will be determined following middle cerebral artery occlusion in rat and mouse (Specific Aim 1)...
  25. BLOOD-BRAIN BARRIER TRANSPORT AND ISCHEMIC BRAIN INJURY
    Richard Keep; Fiscal Year: 2001
    ..and p-[3H] aminohippuric acid (PAH, an organic acid transporter substrate) will be determined following middle cerebral artery occlusion in rat and mouse (Specific Aim 1)...
  26. BLOOD-BRAIN BARRIER TRANSPORT AND ISCHEMIC BRAIN INJURY
    Richard Keep; Fiscal Year: 1999
    ..and p-[3H] aminohippuric acid (PAH, an organic acid transporter substrate) will be determined following middle cerebral artery occlusion in rat and mouse (Specific Aim 1)...
  27. MECHANISMS OF OXIDATIVE INJURY IN VASOGENIC BRAIN EDEMA
    Pak Chan; Fiscal Year: 1990
    ..2) To establish the role of superoxide radicals in ischemic brain edema following occlusion of middle cerebral artery in the rat...
  28. Matrix Metalloproteinases and the Blood-Brain Barrier
    Gary Rosenberg; Fiscal Year: 2009
    ..TIMP-3) induces apoptosis in neurons and oligodendrocytes (OL) in focal ischemia induced by middle cerebral artery occlusion. This suggested that MMPs and TIMP-3 might be important in global ischemia from BCAO...
  29. Matrix Metalloproteinases and the Blood-Brain Barrier
    GARY ALLEN ROSENBERG; Fiscal Year: 2010
    ..TIMP-3) induces apoptosis in neurons and oligodendrocytes (OL) in focal ischemia induced by middle cerebral artery occlusion. This suggested that MMPs and TIMP-3 might be important in global ischemia from BCAO...
  30. S-Nitrosylated Hemoglobin and Ischemic Brain Injury
    David Warner; Fiscal Year: 2009
    ..Using an established, physiologically-controlled rat middle cerebral artery occlusion (MCAO) model, we will 1) Define acute effects of 20 ppm ethyl nitrite inhalation on absolute CBF ..
  31. S-Nitrosylated Hemoglobin and Ischemic Brain Injury
    David Warner; Fiscal Year: 2010
    ..Using an established, physiologically-controlled rat middle cerebral artery occlusion (MCAO) model, we will 1) Define acute effects of 20 ppm ethyl nitrite inhalation on absolute CBF ..
  32. Transcranial Sonothrombolysis with Diagnostic Ultrasound
    Thilo Hoelscher; Fiscal Year: 2010
    ..will help us study these effects and their impact on thrombolysis in vivo in a system that resembles the middle cerebral artery. More important, it will allow us to asses macro- and microvascular recanalization...
  33. Transcranial Sonothrombolysis with Diagnostic Ultrasound
    Thilo Hoelscher; Fiscal Year: 2009
    ..will help us study these effects and their impact on thrombolysis in vivo in a system that resembles the middle cerebral artery. More important, it will allow us to asses macro- and microvascular recanalization...
  34. Transcranial Sonothrombolysis with Diagnostic Ultrasound
    Thilo Hoelscher; Fiscal Year: 2013
    ..will help us study these effects and their impact on thrombolysis in vivo in a system that resembles the middle cerebral artery. More important, it will allow us to asses macro- and microvascular recanalization...
  35. Post-Stroke Aphasia and rTMS Treatment (PART) Study
    Jerzy P Szaflarski; Fiscal Year: 2012
    ..whether fMRI language lateralization can predict AT performance following nerTMS targeted to the left middle cerebral artery (LMCA) stroke areas;(3) to explore the possible synergistic effect of constraint induced aphasia therapy (..
  36. Treatment of acute stroke ethanol and caffeine
    James Grotta; Fiscal Year: 2002
    ..of various doses of ethanol and caffeine can reduce infarct volume by up to 80% after reversible middle cerebral artery occlusion, while the same doses given alone of ethanol are harmful and of caffeine are only slightly ..
  37. Interaction of Estrogen and Tissue Plasminogen Activator
    Shaohua Yang; Fiscal Year: 2009
    ..extends the therapeutic window of rtPA upon pretreatment in female rats in an embolic middle cerebral artery occlusion (MCAO) model...
  38. Interaction of Estrogen and Tissue Plasminogen Activator
    Shaohua Yang; Fiscal Year: 2010
    ..extends the therapeutic window of rtPA upon pretreatment in female rats in an embolic middle cerebral artery occlusion (MCAO) model...
  39. ROLE OF OXYGEN RADICALS AND XANTHINE OXIDASE IN STROKE
    JOSEPH BECKMAN; Fiscal Year: 1990
    ..The stroke is induced by occluding the right middle cerebral artery (MCA) and transiently clamping both carotid arteries for up to 90 minutes, which yields a reproducible, ..
  40. Deregulated lipid metabolism in stroke
    Robert J Dempsey; Fiscal Year: 2013
    ..p21 and p27 through ceramide accumulation, and (c) attenuated Rb phosphorylation after transient middle cerebral artery occlusion (tMCAO) in rat. Our studies strongly support SMS inhibition by D609 leading to cell cycle arrest...
  41. Balanced, polyvalent antiglutamatergic action as a novel approach to efficacious
    Anatoly Martynyuk; Fiscal Year: 2009
    ..properties of 3, 5-DBr-D-Tyr will be studied in vivo using a rat model of stroke caused by transient middle cerebral artery occlusion (MCAO)...
  42. Intranasal deferoxamine to treat stroke in young and older, male and female rats
    SAMUEL SCOTT PANTER; Fiscal Year: 2013
    ..Stroke will be induced by the intraluminal suture middle cerebral artery occlusion (MCAO) model...
  43. Heat Shock Protein Therapeutics for Stroke
    FRANK R contact SHARP; Fiscal Year: 2010
    ..neurons and glia in vitro;(b) FvHsp70 decreases infarct volumes and improves behavioral outcomes following middle cerebral artery occlusions (MCAO) in vivo;(c) and pro-inflammatory and pro-apoptotic genes induced in blood leukocytes ..
  44. ICE FAMILY AND NEURONAL CELL DEATH
    Junying Yuan; Fiscal Year: 1999
    ..A mouse model of stroke, middle cerebral artery (MCA) occlusion, was used to examine the resistance of ischemia injury offered by the mutant ICE...
  45. Vascular Cognitive Impairment Induced by Ischemic Stroke: mechanism and therapy
    Shaohua Yang; Fiscal Year: 2009
    ..on long-term sensorimotor functions, cognitive functions, and anxiety-related behavior in a transient middle cerebral artery occlusion model in rats. Specific Aim 2...
  46. Vascular Cognitive Impairment Induced by Ischemic Stroke: mechanism and therapy
    Shaohua Yang; Fiscal Year: 2010
    ..on long-term sensorimotor functions, cognitive functions, and anxiety-related behavior in a transient middle cerebral artery occlusion model in rats. Specific Aim 2...
  47. Middle Cerebral and Common Artery Occlusion and Poststroke Epilepsy
    Kevin Kelly; Fiscal Year: 2007
    ..Recent pilot studies in our laboratory indicate that transient (3 hr) unilateral (left-sided) middle cerebral artery (MCA) and common carotid artery (CCA) occlusion (MCA/CCAO) results in poststroke epilepsy less frequently ..
  48. Mechanisms of Hyperbaric Oxygen Induced Brain Protection
    John H Zhang; Fiscal Year: 2010
    ..of hyperbaric oxygen induced preconditioning (HBO-PC) in a focal cerebral ischemic model produced by Middle Cerebral Artery Occlusion (MCAO)...
  49. Role of Neutrophil-Platelet Interactions in Vascular Occlusive Disorders
    Nauder Faraday; Fiscal Year: 2009
    ..time, ferric chloride-induced injury of mesenteric arterioles, and transient filament occlusion of the middle cerebral artery. We will examine the effects of neutrophil count and cathepsin G on vascular outcomes by manipulating ..
  50. Stem Cells and Ischemic Brain Injury
    Walter Low; Fiscal Year: 2001
    ..The middle cerebral artery will be occluded unilaterally by ligation distal to the branching striatal vessels...
  51. Stem Cells and Ischemic Brain Injury
    Walter Low; Fiscal Year: 2003
    ..The middle cerebral artery will be occluded unilaterally by ligation distal to the branching striatal vessels...
  52. Role of Neutrophil-Platelet Interactions in Vascular Occlusive Disorders
    Nauder Faraday; Fiscal Year: 2010
    ..time, ferric chloride-induced injury of mesenteric arterioles, and transient filament occlusion of the middle cerebral artery. We will examine the effects of neutrophil count and cathepsin G on vascular outcomes by manipulating ..
  53. Stem Cells and Ischemic Brain Injury
    Walter Low; Fiscal Year: 2002
    ..The middle cerebral artery will be occluded unilaterally by ligation distal to the branching striatal vessels...
  54. Stem Cells and Ischemic Brain Injury
    Walter Low; Fiscal Year: 2002
    ..The middle cerebral artery will be occluded unilaterally by ligation distal to the branching striatal vessels...
  55. Stem Cells and Ischemic Brain Injury
    Walter Low; Fiscal Year: 2003
    ..The middle cerebral artery will be occluded unilaterally by ligation distal to the branching striatal vessels...
  56. Stem Cells and Ischemic Brain Injury
    Walter Low; Fiscal Year: 2002
    ..The middle cerebral artery will be occluded unilaterally by ligation distal to the branching striatal vessels...
  57. NMDA ANTAGONISTS IN THE TREATMENT OF STROKE
    Gary Steinberg; Fiscal Year: 1991
    ..rabbits by transorbital, clip occlusion of the internal carotid artery, anterior cerebral artery and middle cerebral artery. The degree of cerebral ischemia will be determined using electrophysiological (somatosensory evoked ..
  58. INFLAMMATORY AND THROMBOTIC CELL INTERACTIONS IN STROKE
    Leslie Ritter; Fiscal Year: 2000
    ..Aim 1 will be accomplished in an animal model of middle cerebral artery occlusion by directly observing leukocyte-platelet interactions in the microcirculation of the reperfused ..
  59. NMDA ANTAGONISTS IN THE TREATMENT OF STROKE
    Gary Steinberg; Fiscal Year: 1993
    ..rabbits by transorbital, clip occlusion of the internal carotid artery, anterior cerebral artery and middle cerebral artery. The degree of cerebral ischemia will be determined using electrophysiological (somatosensory evoked ..
  60. NMDA ANTAGONISTS IN THE TREATMENT OF STROKE
    Gary Steinberg; Fiscal Year: 1992
    ..rabbits by transorbital, clip occlusion of the internal carotid artery, anterior cerebral artery and middle cerebral artery. The degree of cerebral ischemia will be determined using electrophysiological (somatosensory evoked ..
  61. Mechanisms of Hyperbaric Oxygen Induced Brain Protection
    John H Zhang; Fiscal Year: 2013
    ..of hyperbaric oxygen induced preconditioning (HBO-PC) in a focal cerebral ischemic model produced by Middle Cerebral Artery Occlusion (MCAO)...
  62. MECHANISMS OF MOTOR RECOVERY AFTER SUBTOTAL BRAIN INJURY
    Robert J Morecraft; Fiscal Year: 2012
    ..part of the motor cortex that is typically involved in the most common form of human stroke, namely middle cerebral artery infarction...
  63. MECHANISMS OF MOTOR RECOVERY AFTER SUBTOTAL BRAIN INJURY
    Robert J Morecraft; Fiscal Year: 2010
    ..part of the motor cortex that is typically involved in the most common form of human stroke, namely middle cerebral artery infarction...
  64. APOLIPOPROTEIN E AND THE ISCHEMIC BRAIN
    David Warner; Fiscal Year: 1999
    ..Using a recovery model of temporary middle cerebral artery occlusion, this research will examine mice deficient for Apo E and genetically engineered mice carrying ..
  65. APOLIPOPROTEIN E AND THE ISCHEMIC BRAIN
    David Warner; Fiscal Year: 2000
    ..Using a recovery model of temporary middle cerebral artery occlusion, this research will examine mice deficient for Apo E and genetically engineered mice carrying ..
  66. APOLIPOPROTEIN E AND THE ISCHEMIC BRAIN
    David Warner; Fiscal Year: 2001
    ..Using a recovery model of temporary middle cerebral artery occlusion, this research will examine mice deficient for Apo E and genetically engineered mice carrying ..
  67. Neurovascular Adhesion Receptors and Barrier Integrity
    Gregory Del Zoppo; Fiscal Year: 2007
    ..the basal lamina are a major determinant of the blood-brain barrier phenotype, ii) that focal ischemia by middle cerebral artery occlusion (MCAO) disrupts receptor-matrix interactions, and iii) that interruptions of the receptor-matrix ..
  68. Neurovascular Adhesion Receptors and Barrier Integrity
    Gregory Del Zoppo; Fiscal Year: 2006
    ..the basal lamina are a major determinant of the blood-brain barrier phenotype, ii) that focal ischemia by middle cerebral artery occlusion (MCAO) disrupts receptor-matrix interactions, and iii) that interruptions of the receptor-matrix ..
  69. CHORIOAMNIONITIS--CYTOKINES ALTER PERINATAL HEMODYNAMICS
    TOBY YANOWITZ; Fiscal Year: 2001
    ..whether premature infants born to mothers with chorioamnionitis have 1) decreased cardiac function and middle cerebral artery Doppler blood flow velocity in-utero and after birth; 2) altered cerebral oxygen availability as measured ..
  70. CHORIOAMNIONITIS--CYTOKINES ALTER PERINATAL HEMODYNAMICS
    TOBY YANOWITZ; Fiscal Year: 1999
    ..whether premature infants born to mothers with chorioamnionitis have 1) decreased cardiac function and middle cerebral artery Doppler blood flow velocity in-utero and after birth; 2) altered cerebral oxygen availability as measured ..
  71. CHORIOAMNIONITIS--CYTOKINES ALTER PERINATAL HEMODYNAMICS
    TOBY YANOWITZ; Fiscal Year: 2003
    ..whether premature infants born to mothers with chorioamnionitis have 1) decreased cardiac function and middle cerebral artery Doppler blood flow velocity in-utero and after birth; 2) altered cerebral oxygen availability as measured ..
  72. CHORIOAMNIONITIS--CYTOKINES ALTER PERINATAL HEMODYNAMICS
    TOBY YANOWITZ; Fiscal Year: 2000
    ..whether premature infants born to mothers with chorioamnionitis have 1) decreased cardiac function and middle cerebral artery Doppler blood flow velocity in-utero and after birth; 2) altered cerebral oxygen availability as measured ..
  73. CHORIOAMNIONITIS--CYTOKINES ALTER PERINATAL HEMODYNAMICS
    TOBY YANOWITZ; Fiscal Year: 2002
    ..whether premature infants born to mothers with chorioamnionitis have 1) decreased cardiac function and middle cerebral artery Doppler blood flow velocity in-utero and after birth; 2) altered cerebral oxygen availability as measured ..
  74. The Role of Astrocytic Transglutaminase 2 in Mediating Ischemic Stroke Damage
    JULIANNE M FEOLA; Fiscal Year: 2012
    ..under ischemic condition, and 3) astrocyte-specific knockout of TG2 will reduce the infarct volume after a middle cerebral artery ligation (MCAL) in vivo. For the first two aims, I will use cell culture models...
  75. THE RELATIONSHIP OF SERUM PROTEINS TO STROKE SEVERITY
    Edward Jauch; Fiscal Year: 2002
    ..the severity of neurologic deficit, volume of infarct on CT and magnetic resonance imaging, flow in the middle cerebral artery as measured by magnetic resonance angiography, presence of intracerebral hemorrhage, and long-term outcome...
  76. CENTER FOR CNS INJURY STUDIES
    Mitchell Chesler; Fiscal Year: 2000
    ..Extracellular Asc will be measured in hypoxic brain slices and in ischemic cerebral cortex after middle cerebral artery occlusion. Intracellular Asc will be estimated from extracellular volumes and total tissue levels...
  77. Insular Autonomic Function in Depression
    Donald Royall; Fiscal Year: 2009
    ..48% of middle cerebral artery strokes affect the insula...
  78. CENTER FOR CNS INJURY STUDIES
    Mitchell Chesler; Fiscal Year: 1999
    ..Extracellular Asc will be measured in hypoxic brain slices and in ischemic cerebral cortex after middle cerebral artery occlusion. Intracellular Asc will be estimated from extracellular volumes and total tissue levels...
  79. Neonatal Brain Ischemia: Neuroimaging as a Basis For Rational Stem Cell Therapy
    Stephen Ashwal; Fiscal Year: 2010
    ..Our goal is to use advanced magnetic resonance imaging (MRI) in a standard rat pup model of unilateral middle cerebral artery occlusion with hypoxia (Rice- Vannucci, RVM) to: (1) monitor non-invasively (as might be done clinically) ..
  80. Neonatal Brain Ischemia: Neuroimaging as a Basis For Rational Stem Cell Therapy
    Stephen Ashwal; Fiscal Year: 2009
    ..Our goal is to use advanced magnetic resonance imaging (MRI) in a standard rat pup model of unilateral middle cerebral artery occlusion with hypoxia (Rice- Vannucci, RVM) to: (1) monitor non-invasively (as might be done clinically) ..
  81. A NEW STRATEGY FOR PROTECTION FROM CEREBRAL ISCHEMIA
    Ying Xia; Fiscal Year: 2009
    ..The most striking finding is that EA remarkably reduces brain infarction due to the occlusion of middle cerebral artery, which is dependent on the EA-triggered cellular/molecular events in the brain...
  82. A NEW STRATEGY FOR PROTECTION FROM CEREBRAL ISCHEMIA
    Ying Xia; Fiscal Year: 2010
    ..The most striking finding is that EA remarkably reduces brain infarction due to the occlusion of middle cerebral artery, which is dependent on the EA-triggered cellular/molecular events in the brain...
  83. CELL EXCITATION IN ISCHEMIC BRAIN INJURY
    Roger Simon; Fiscal Year: 1992
    ..We have now developed a new and highly reproducible technique of middle cerebral artery occlusion in the adult rat, and used in vivo microdialysis to quantify the changes in extracellular amino ..
  84. REGULATION OF BRAIN THROMBOSIS IN STROKE MODELS
    Berislav Zlokovic; Fiscal Year: 1999
    ..initially developed a mouse stroke model with fibrin-rich microvascular deposits and obstructions due to middle cerebral artery occlusion/reperfusion or thrombin-induced thromboembolism...
  85. REGULATION OF BRAIN THROMBOSIS IN STROKE MODELS
    Berislav Zlokovic; Fiscal Year: 2001
    ..initially developed a mouse stroke model with fibrin-rich microvascular deposits and obstructions due to middle cerebral artery occlusion/reperfusion or thrombin-induced thromboembolism...
  86. REGULATION OF BRAIN THROMBOSIS IN STROKE MODELS
    Berislav Zlokovic; Fiscal Year: 2002
    ..initially developed a mouse stroke model with fibrin-rich microvascular deposits and obstructions due to middle cerebral artery occlusion/reperfusion or thrombin-induced thromboembolism...
  87. REGULATION OF BRAIN THROMBOSIS IN STROKE MODELS
    Berislav Zlokovic; Fiscal Year: 2000
    ..initially developed a mouse stroke model with fibrin-rich microvascular deposits and obstructions due to middle cerebral artery occlusion/reperfusion or thrombin-induced thromboembolism...
  88. Treatment of stroke with a clinically approved proteasome inhibitor
    Li Zhang; Fiscal Year: 2010
    Occlusion of the middle cerebral artery elicits a progressive vascular dysfunction, which contributes to the evolution of brain injury...
  89. Treatment of stroke with a clinically approved proteasome inhibitor
    Li Zhang; Fiscal Year: 2009
    Occlusion of the middle cerebral artery elicits a progressive vascular dysfunction, which contributes to the evolution of brain injury...
  90. TWEAK-Induced Neuroinflammation and Cerebral Edema
    MANUEL SALVADOR YEPES; Fiscal Year: 2013
    ..We have also found that following middle cerebral artery occlusion (MCAO) the expression of TWEAK and Fn14 increases in the ischemic area, and that inhibition of ..
  91. Brain Vasodilator Responses in Healthy and Cognitively Impaired Humans
    JILL NICOLE BARNES; Fiscal Year: 2012
    ..peripheral vasodilator responses are blunted in MCI patients by comparing CO2-mediated vasodilation in the middle cerebral artery (MCA) and the forearm blood flow response to reactive hyperemia in 3 groups: 1) young healthy adults;2) ..
  92. Neurovascular Adhesion Receptors and Barrier Integrity
    Gregory J del Zoppo; Fiscal Year: 2010
    ..the basal lamina are a major determinant of the blood-brain barrier phenotype, ii) that focal ischemia by middle cerebral artery occlusion (MCA:O) disrupts receptor-matrix interactions, and iii) that interruptions of the receptor-..
  93. Impacting Oxidative Stress and Cell Injury through Novel Pathways of the Wnt Gene
    Kenneth Maiese; Fiscal Year: 2009
    ..2-catenin, SIRT1, and caspase activity to foster cytoprotection in animal models of oxidative stress with middle cerebral artery occlusion (MCAO)/reperfusion...
  94. Neurovascular Adhesion Receptors and Barrier Integrity
    Gregory Del Zoppo; Fiscal Year: 2009
    ..the basal lamina are a major determinant of the blood-brain barrier phenotype, ii) that focal ischemia by middle cerebral artery occlusion (MCA:O) disrupts receptor-matrix interactions, and iii) that interruptions of the receptor-..
  95. Neurovascular Adhesion Receptors and Barrier Integrity
    Gregory Del Zoppo; Fiscal Year: 2007
    ..the basal lamina are a major determinant of the blood-brain barrier phenotype, ii) that focal ischemia by middle cerebral artery occlusion (MCA:O) disrupts receptor-matrix interactions, and iii) that interruptions of the receptor-..
  96. Mechanisms of Endothelial Cell Hyperpolarization
    SEAN MARRELLI; Fiscal Year: 2009
    ..RT-PCR and immunohistochemistry), measure [Ca2+]i and Ca2+ influx in response to ATP in freshly isolated middle cerebral artery (MCA) ECs and in the ECs of pressurized MCA (Fura 2 dye), and demonstrate the role of the identified TRP ..
  97. Osmotherapy in Acute Ischemic Stroke
    Anish Bhardwaj; Fiscal Year: 2004
    ..most efficacious treatment paradigm with HS for cerebral edema following transient as well as permanent middle cerebral artery occlusion (MCAO)...
  98. Continuous Cerebral Autoregulation Monitoring to Reduce Brain Injury from Cardiac
    Charles Hogue; Fiscal Year: 2009
    ..software that continuously compares the relation between arterial blood pressure and CBF velocity of the middle cerebral artery measured with transcranial Doppler and with cerebral oximetry measured with near infrared spectroscopy...