Genomes and Genes
Summary: The HEART and the BLOOD VESSELS by which BLOOD is pumped and circulated through the body.
Publications323 found, 100 shown here
- Biological properties of baicalein in cardiovascular systemYu Huang
Department of Physiology, Chinese University of Hong Kong, Shatin, NT, Hong Kong, China
Curr Drug Targets Cardiovasc Haematol Disord 5:177-84. 2005..The pharmacological findings have highlighted the therapeutic potentials of using plant-derived baicalein and its analogs for the treatment of arteriosclerosis and hypertension...
- Aldosterone: effects on the kidney and cardiovascular systemMarie Briet
Department of Medicine, Sir Mortimer B Davis Jewish General Hospital and Lady Davis Institute for Medical Research, McGill University, 3755 Cote Ste Catherine Road, Montreal, QC H3T 1E2, Canada
Nat Rev Nephrol 6:261-73. 2010..In the cardiovascular system, aldosterone has specific hypertrophic and fibrotic effects and can alter endothelial function...
- MicroRNAs in the cardiovascular systemMingyue Han
Department of Cell Biology and Molecular Medicine, Cardiovascular Research Institute, University of Medicine and Dentistry of New Jersey, Newark, NJ 07103, USA
Curr Opin Cardiol 26:181-9. 2011..In addition, they are potentially highly effective therapeutic tools. In this review, we will summarize the recent advancements in the field...
- Expression pattern of connexin gene products at the early developmental stages of the mouse cardiovascular systemB Delorme
Laboratoire de Genetique et Physiologie du Developpement, UMR C9943, Institut de Biologie du Developpement de Marseille, France
Circ Res 81:423-37. 1997..In addition, comparison of Cx40 and Cx43 distribution at the above developmental stages has shown that these Cxs have overlapping (left ventricle) or complementary (atrial tissue and right ventricle) expression patterns...
- CaMKII in the cardiovascular system: sensing redox statesJeffrey R Erickson
Department of Pharmacology, University of California at Davis, Davis, California 95616, USA
Physiol Rev 91:889-915. 2011..protein kinase II (CaMKII) is now recognized to play a central role in pathological events in the cardiovascular system. CaMKII has diverse downstream targets that promote vascular disease, heart failure, and arrhythmias, so ..
- Prolactin-releasing peptide regulates the cardiovascular system via corticotrophin-releasing hormoneT Yamada
Department of Regulatory Biology, Graduate School of Science and Engineering, Saitama University, Sakura ku, Saitama, Japan
J Neuroendocrinol 21:586-93. 2009..Thus, we conclude that PrRP stimulated CRH neurones in the PVN and that CRH might regulate the cardiovascular system via the sympathetic nervous system.
- Invited review: aging and the cardiovascular systemAlberto U Ferrari
Dipartimento di Medicina, Universita di Milano Bicocca, Milano, Italy
J Appl Physiol (1985) 95:2591-7. 2003..Reflexes arising from cardiopulmonary vagal afferents are also blunted in aged individuals. The cardiovascular and reflex changes brought about by aging may have significant implications for circulatory homeostasis in health and disease...
- Neural influences on cardiovascular variability: possibilities and pitfallsSimon C Malpas
Circulatory Control Laboratory, Department of Physiology, University of Auckland, Auckland, New Zealand
Am J Physiol Heart Circ Physiol 282:H6-20. 2002Altered variability in the cardiovascular system is associated with a range of cardiovascular diseases and increased mortality...
- Effects of thyroid hormone on the cardiovascular systemSerafino Fazio
Department of Clinical Medicine and Cardiovascular Sciences, University of Naples Federico II School of Medicine, 80131, Naples, Italy
Recent Prog Horm Res 59:31-50. 2004..Extensive evidence indicates that the cardiovascular system responds to the minimal but persistent changes in circulating thyroid hormone levels, which are typical of ..
- Cyclic nucleotide phosphodiesterase activity, expression, and targeting in cells of the cardiovascular systemDonald H Maurice
Heart and Stroke Foundation of Ontario Career Investigator, Department of Pharmacology and Toxicology, Botterell Hall, A215, Queen s University, Kingston, Ontario, Canada, K7L 3N6
Mol Pharmacol 64:533-46. 2003..metabolism, contractility, motility, and transcription in virtually all cell types, including those of the cardiovascular system. Considerable effort over the last 20 years has allowed identification of the cellular components involved ..
- Cardiovascular effects of DPP-4 inhibition: beyond GLP-1Gian Paolo Fadini
Department of Clinical and Experimental Medicine, University of Padova, Faculty of Medicine, Padova, Italy
Vascul Pharmacol 55:10-6. 2011..It has been shown that GLP-1 signaling is also active in the cardiovascular system, where it may exert beneficial effects...
- CRF2 receptors are highly expressed in the human cardiovascular system and their cognate ligands urocortins 2 and 3 are potent vasodilatorsKatherine E Wiley
Clinical Pharmacology Unit, School of Clinical Medicine, Centre for Clinical Investigation, University of Cambridge, Box 110, Level 6, Cambridge CB2 2QQ
Br J Pharmacol 143:508-14. 2004..Our objectives were to determine the presence of CRF(2) receptors in the human cardiovascular system using the selective radioligand [(125)I]antisauvagine 30...
- Actions of aldosterone in the cardiovascular system: the good, the bad, and the ugly?Michael Gekle
Julius Bernstein Institut für Physiologie, Universität Halle Wittenberg, Magdeburger Strasse 6, 06097 Halle Saale, Germany
Pflugers Arch 458:231-46. 2009..for cardiovascular electrophysiology and rhythmogenesis, represent the good face of aldosterone in the cardiovascular system. Triggering of persistent arterial hypertension with all the detrimental secondary effects on heart, ..
- O-GlcNAc signaling in the cardiovascular systemGladys A Ngoh
Institute of Molecular Cardiology, University of Louisville, 580 South Preston St, 404C, Baxter II 404C, Louisville, KY 40202, USA
Circ Res 107:171-85. 2010..In this review, we focus on the emerging evidence of its involvement in the cardiovascular system. In particular, we highlight evidence of protein O-GlcNAcylation as an autoprotective alarm or stress ..
- Expression patterns of FHL/SLIM family members suggest important functional roles in skeletal muscle and cardiovascular systemP H Chu
UCSD Salk Program in Molecular Medicine, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0613, USA
Mech Dev 95:259-65. 2000..three highly-related genes indicates that they are expressed in an overlapping pattern in the developing cardiovascular system, and skeletal muscle...
- cAMP-Specific phosphodiesterase-4 enzymes in the cardiovascular system: a molecular toolbox for generating compartmentalized cAMP signalingMiles D Houslay
Molecular Pharmacology Group, Division of Biochemistry and Molecular Biology, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, Scotland, UK
Circ Res 100:950-66. 2007....
- The in vivo cardiovascular effects of box jellyfish Chironex fleckeri venom in rats: efficacy of pre-treatment with antivenom, verapamil and magnesium sulphateSharmaine Ramasamy
Monash Venom Group, Department of Pharmacology, Monash University, Clayton, Victoria 3800, Australia
Toxicon 43:685-90. 2004..We show for the first time, the cardiovascular effects of a C. fleckeri venom sample free of tentacular contamination and the potential of MgSO(4) as an adjunct therapy for the treatment of potentially fatal C. fleckeri envenomings...
- Salt, aldosterone, and insulin resistance: impact on the cardiovascular systemGuido Lastra
Division of Endocrinology and Diabetes, Department of Internal Medicine, University of Missouri School of Medicine, D109 HSC Diabetes Center, One Hospital Drive, Columbia, MO 65212, USA
Nat Rev Cardiol 7:577-84. 2010..is not limited to classic insulin-sensitive tissues such as skeletal muscle, but it also affects the cardiovascular system, where it participates in the development of CVD and CKD...
- Chronic high-carbohydrate, high-fat feeding in rats induces reversible metabolic, cardiovascular, and liver changesHemant Poudyal
School of Biomedical Sciences, The University of Queensland, Brisbane, Australia
Am J Physiol Endocrinol Metab 302:E1472-82. 2012..These results suggest that chronic H diet feeding for 32 wk mimics the diet-induced cardiovascular and metabolic changes in middle age and that chia seed may serve as an alternative dietary strategy in the management of these changes...
- Natriuretic peptide receptor B signaling in the cardiovascular system: protection from cardiac hypertrophyInes Pagel-Langenickel
National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
J Mol Med (Berl) 85:797-810. 2007..NPR-B for the first time to a cardiac phenotype in vivo and underlines the importance of the NP in the cardiovascular system. This manuscript will focus on the role of NPR-B and its ligand C-type natriuretic peptide in ..
- Redox signaling in central neural regulation of cardiovascular functionMatthew C Zimmerman
Department of Anatomy and Cell Biology, Roy J and Lucille A Carver College of Medicine, The University of Iowa, Iowa City 52245, USA
Prog Biophys Mol Biol 84:125-49. 2004..The main objective of this review is to discuss the recent progress and prospects for this new field of central redox signaling in cardiovascular regulation, while also addressing the molecular tools that have spurred it forward...
- Aryl hydrocarbon receptor-independent toxicity of weathered crude oil during fish developmentJohn P Incardona
Ecotoxicology and Environmental Fish Health Program, Environmental Conservation Division, Northwest Fisheries Science Center, National Oceanic and Atmospheric Administration, Seattle, Washington 98112, USA
Environ Health Perspect 113:1755-62. 2005..These findings have multiple implications for the assessment of PAH impacts on coastal habitats...
- Sensing pressure in the cardiovascular system: Gq-coupled mechanoreceptors and TRP channelsReza Sharif-Naeini
IPMC CNRS, 660 route des Lucioles, Universite de Nice Sophia Antipolis, 06560 Valbonne, France
J Mol Cell Cardiol 48:83-9. 2010..TRPC6 is also involved in load-induced cardiac hypertrophy. In this review, we will focus on the molecular basis of pressure sensing in the cardiovascular system and associated disease states.
- A general model for the origin of allometric scaling laws in biologyG B West
Theoretical Division, T 8, Mail Stop B285, Los Alamos National Laboratory, Los Alamos, NM 87545, USA
Science 276:122-6. 1997..More generally, the model predicts structural and functional properties of vertebrate cardiovascular and respiratory systems, plant vascular systems, insect tracheal tubes, and other distribution networks...
- Actions and interactions of nitric oxide, carbon monoxide and hydrogen sulphide in the cardiovascular system and in inflammation--a tale of three gases!Ling Li
Pharmaceutical Science Division, King s College London, Franklin Wilkins Building, 150 Stamford Street, London SE19NH, UK
Pharmacol Ther 123:386-400. 2009..Within the cardiovascular system, for example, all are vasodilators, promote angiogenesis and vascular remodelling and are protective ..
- Genetic mechanisms controlling cardiovascular developmentJamie Bentham
Department of Cardiovascular Medicine and Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX37BN, UK
Ann N Y Acad Sci 1123:10-9. 2008..A long-term goal in CHD is to manipulate these pathways to enhance buffering and prevent disease in a manner analogous to the use of folate in preventing neural tube defects...
- A "love triangle" elicited by electrochemistry: complex interactions among cardiac sympathetic afferent, chemo-, and baroreflexesYan hua Du
J Appl Physiol 102:9-10. 2007
- Pharmacologically distinct cardiovascular effects of box jellyfish (Chironex fleckeri) venom and a tentacle-only extract in ratsSharmaine Ramasamy
Monash Venom Group, Department of Pharmacology, Monash University, VIC 3800, Australia
Toxicol Lett 155:219-26. 2005..We show, for the first time, that a pure venom sample extracted from C. fleckeri nematocysts and a tentacle extract have cardiovascular effects in the anaesthetised rat which are different and pharmacologically distinct...
- Cross-talk between the kidney and the cardiovascular systemKerstin Amann
Department Pathology, Friedrich Alexander University Erlangen, Erlangen, Germany
J Am Soc Nephrol 17:2112-9. 2006..The mechanisms that link dysfunction of the kidney and the cardiovascular system are being sought...
- Development-related changes in the expression of shear stress responsive genes KLF-2, ET-1, and NOS-3 in the developing cardiovascular system of chicken embryosBianca C W Groenendijk
Department of Anatomy and Embryology, Leiden University Medical Center, Leiden, The Netherlands
Dev Dyn 230:57-68. 2004..We demonstrate overlapping expression patterns of KLF-2 and NOS-3 in the narrow parts of the cardiovascular system, like the cardiac inflow tract, the atrioventricular canal, outflow tract, and in the early stages in the ..
- Potentiation of baroreceptor reflex response by heat shock protein 70 in nucleus tractus solitarii confers cardiovascular protection during heatstrokeP L Li
Department of Biological Science and Center for Neuroscience, National Sun Yat-Sen University, Taiwan, Republic of China
Circulation 103:2114-9. 2001....
- Exposure to concentrated ambient particles does not affect vascular function in patients with coronary heart diseaseNicholas L Mills
Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, United Kingdom
Environ Health Perspect 116:709-15. 2008..Exposure to fine particulate air pollution is associated with increased cardiovascular morbidity and mortality. We previously demonstrated that exposure to dilute diesel exhaust causes vascular dysfunction in humans...
- Vitamin D and the cardiovascular systemJorge N Artaza
Charles Drew University of Medicine and Science, Los Angeles, CA 90059, USA
Clin J Am Soc Nephrol 4:1515-22. 2009....
- Endothelins and NADPH oxidases in the cardiovascular systemKarigowda J Dammanahalli
Department of Physiology, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA
Clin Exp Pharmacol Physiol 35:2-6. 2008..Rac1 is an important regulator of NADPH oxidase. There is ample evidence supporting direct stimulation by Rac1 of NADPH oxidase activity. In addition, Rac1-induced cardiomyocyte hypertrophy is mediated by the generation of ROS...
- An emerging role of dipeptidyl peptidase 4 (DPP4) beyond glucose control: potential implications in cardiovascular diseaseJixin Zhong
Davis Heart and Lung Research Institute and Division of Cardiovascular Medicine, The Ohio State University, Columbus, OH, USA
Atherosclerosis 226:305-14. 2013..Several prospective randomized controlled clinical trials in humans with established atherosclerosis are testing the effects of DPP4 inhibition on hard cardiovascular events...
- Free radical biology of the cardiovascular systemAlex F Chen
Department of Surgery, McGowan Institute of Regenerative Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Clin Sci (Lond) 123:73-91. 2012..much enthusiasm for the continued use of antioxidants to mitigate free-radical-induced changes in the cardiovascular system. In the present paper, we review the clinical use of antioxidants by providing the rationale for their use ..
- NO as a mediator during the early development of the cardiovascular system in the zebrafishBernd Pelster
Department of Zoology and Limnology, University of Innsbruck, Austria
Comp Biochem Physiol A Mol Integr Physiol 142:215-20. 2005As a general pattern innervation of the cardiovascular system appears late during development in vertebrate embryos, and cardiovascular control may be achieved by hormonal activity in early stages...
- Cardiovascular responses to hypothalamic arcuate nucleus stimulation in the rat: role of sympathetic and vagal efferentsTakeshi Nakamura
Department of Neurological Surgery, MSB H 586, UMDNJ New Jersey Medical School, 185 South Orange Ave, Newark, NJ 07103, USA
Hypertension 54:1369-75. 2009....
- Beta 3-adrenoceptors in the cardiovascular systemChantal Gauthier
INSERM U533, l institut du thorax, Nantes, France
Clin Hemorheol Microcirc 37:193-204. 2007..of a new beta-adrenoceptor subtype, beta(3), in addition to beta(1) and beta(2)-adrenoceptor in the cardiovascular system has changed the view of the roles of the sympathetic system...
- Na+/H+ exchange inhibition delays the onset of hypovolemic circulatory shock in pigsDongmei Wu
Department of Research, Division of Neonatology, Mount Sinai Medical Canter, Miami Beach, Florida 33140, USA
Shock 29:519-25. 2008..We conclude that NHE-1 inhibition attenuates ischemic myocardial hypercontracture, cardiovascular decompensation, delays the onset of hypovolemic circulatory shock, and prevents early death in severe hemorrhage...
- Is hypertension an inflammatory disease?Jian Jun Li
Department of Cardiology, Renmin Hospital, Wuhan University School of Medicine, Wuhan 430060, People s Republic of China
Med Hypotheses 64:236-40. 2005....
- Sex and the cardiovascular system: the intriguing tale of how women and men regulate cardiovascular function differentlyVirginia H Huxley
Department of Medical Pharmacology and Physiology, Center for Gender Physiology and Environmental Adaptation, University of Missouri School of Medicine, Columbia, Missouri 65212, USA
Adv Physiol Educ 31:17-22. 2007..This article focuses on the cardiovascular system, with examples of sex differences in the control of coronary function, blood pressure, and volume...
- Assessment of the cardiovascular system in pediatric chronic kidney disease: a pilot studyJutta Muscheites
Department of Pediatrics, University of Rostock, Rostock, Germany
Pediatr Nephrol 23:2233-9. 2008..Therefore, routine assessment of FMD may be a useful tool to identify CKD patients at risk of progressive cardiovascular morbidity...
- The pharmacology of Malo maxima jellyfish venom extract in isolated cardiovascular tissues: A probable cause of the Irukandji syndrome in Western AustraliaRan Li
Cardiovascular Therapeutics Unit, Department of Pharmacology, The University of Melbourne, Grattan Street, Parkville, Victoria 3010, Australia
Toxicol Lett 201:221-9. 2011..These effects are consistent with the catecholamine excess thought to cause Irukandji syndrome, with additional actions of CGRP release...
- Nprl3 is required for normal development of the cardiovascular systemMonika S Kowalczyk
MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, UK
Mamm Genome 23:404-15. 2012..NPRL3 is a candidate gene for harbouring mutations in individuals with developmental abnormalities of the cardiovascular system.
- Characterization of Angiotensin-(1-7) effects on the cardiovascular system in an experimental model of type-1 diabetesMariam H M Yousif
Department of Pharmacology and Toxicology, Faculty of Medicine, Kuwait University, Kuwait
Pharmacol Res 66:269-75. 2012..Collectively, these data shed new insights into the likely mechanism of action through which the ACE2/Ang-(1-7)/Mas receptor axis prevents Type 1 diabetes-induced cardiovascular dysfunction...
- Estrogen, aging and the cardiovascular systemJames P Stice
Molecular and Cellular Cardiology, University of California Davis, Davis, CA 95616, USA
Future Cardiol 5:93-103. 2009..Estrogens may decrease the expression of soluble epoxide hydrolase, which has deleterious effects on the cardiovascular system through metabolism of epoxyeicosatrienoic acids...
- Role for primary cilia as flow detectors in the cardiovascular systemKim Van der Heiden
Department of Anatomy and Embryology, Leiden University Medical Center, Leiden, The Netherlands
Int Rev Cell Mol Biol 290:87-119. 2011The cardiovascular system is exposed to biochemical and biomechanical signals...
- Cardiovascular function of a glutamatergic projection from the hypothalamic paraventricular nucleus to the nucleus tractus solitarius in the ratT Kawabe
Department of Neurological Surgery, UMDNJ New Jersey Medical School, Newark, NJ 07103, USA
Neuroscience 153:605-17. 2008....
- Methylation of the estrogen receptor gene is associated with aging and atherosclerosis in the cardiovascular systemW S Post
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Cardiovasc Res 43:985-91. 1999..In this study, we sought to determine whether such age-related methylation occurs in the cardiovascular system, and whether it is associated with atherosclerotic disease.
- Cardiovascular effects and lethality of venom from nematocysts of the box-jellyfish Chiropsalmus quadrigatus (Habu-kurage) in anaesthetized ratsKatsuhiko Noguchi
Department of Pharmacology, School of Medicine, Faculty of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903 0215, Japan
Toxicon 45:519-26. 2005..Data show that C. quadrigatus venom has both vasoconstrictor and cardiodepressive effects in rats, and suggest that a calcium channel blocker can protect against the cardiovascular and lethal effects of the venom...
- Pharmacology of gap junctions in the cardiovascular systemStefan Dhein
Clinic for Cardiac Surgery, Heart Centre Leipzig, University of Leipzig, Struempellstr 39, 04289 Leipzig, Germany
Cardiovasc Res 62:287-98. 2004..channels provide the basis for intercellular communication and play an important physiological role in the cardiovascular system for maintenance of the normal cardiac rhythm, regulation of vascular tone, endothelial function and ..
- Developmental toxicity screening in zebrafishCatherine W McCollum
Center for Nuclear Receptors and Cell Signaling, University of Houston, Texas 77204, USA
Birth Defects Res C Embryo Today 93:67-114. 2011..We also compare the available data in zebrafish toxicity assays with two databases containing mammalian toxicity data. Finally, we identify gaps in our collective knowledge that are ripe for future studies...
- 5-hydroxytryptamine in the cardiovascular system: focus on the serotonin transporter (SERT)Wei Ni
Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI, USA
Clin Exp Pharmacol Physiol 33:575-83. 2006..6. In summary, the function of SERT in the CV system is just beginning to be revealed...
- Amelioration of central cardiovascular regulatory dysfunction by tropomyocin receptor kinase B in a mevinphos intoxication model of brain stem deathS H H Chan
Center for Translational Researchin Biomedical Sciences, Chang Gung Memorial Hospital Kaohsiung Medical Center, Kaohsiung, Taiwan
Br J Pharmacol 164:2015-28. 2011..We investigated the role of tropomyocin receptor kinase B (TrkB) and its downstream signalling pathways in the rostral ventrolateral medulla (RVLM) during experimental brain stem death...
- Differences in the responses of the pituitary beta-endorphin and cardiovascular system to ethanol and stress as a function of family historyXing Dai
Department of Psychiatry, Douglas Hospital Research Centre, McGill University, Montreal, Quebec, Canada
Alcohol Clin Exp Res 26:1171-80. 2002..These studies investigated the response of pituitary beta-endorphin to stress and the effect of alcohol on the stress response in subjects at low (LR) and high (HR) risk of alcoholism, as determined from their family history...
- Cardiovascular effects of adrenocorticotropin microinjections into the rostral ventrolateral medullary pressor area of the ratTetsuya Kawabe
Department of Neurological Surgery, MSB H 586, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, 07103, USA
Brain Res 1102:117-26. 2006..This is the first report showing central cardiovascular actions of ACTH...
- Estrogen and the cardiovascular systemA A Knowlton
Molecular and Cellular Cardiology, Department of Medicine, University of California, Davis, CA 95616, USA
Pharmacol Ther 135:54-70. 2012..Further basic research into the underlying molecular mechanisms of estrogen's actions is essential to provide a better comprehension of the many properties of this powerful hormone...
- TRPM4 channels in the cardiovascular system: physiology, pathophysiology, and pharmacologyHugues Abriel
Department of Clinical Research, Swiss National Centre of Competence in Research NCCR TransCure, University of Bern, Switzerland
Biochem Pharmacol 84:873-81. 2012..These channels are widely expressed in many different tissues, including those of the cardiovascular system. The transient receptor potential channel melastatin 4 (TRPM4) is a Ca(2+)-activated non-specific cationic ..
- Differential engagements of glutamate and GABA receptors in cardiovascular actions of endogenous nNOS or iNOS at rostral ventrolateral medulla of ratsSamuel H H Chan
Center for Neuroscience, National Sun Yat Sen University, Kaohsiung 80424, Taiwan, Republic of China
Br J Pharmacol 138:584-93. 2003..In addition, whereas NO derived from nNOS induced sympathoexcitation via both NMDA and non-NMDA receptors in the RVLM, NO generated by iNOS elicited sympathoinhibition via GABA(A) receptors...
- Incorporating autoregulatory mechanisms of the cardiovascular system in three-dimensional finite element models of arterial blood flowH J Kim
Department of Aerospace Engineering Sciences, University of Colorado at Boulder, Boulder, CO 80309, USA
Ann Biomed Eng 38:2314-30. 2010The cardiovascular system is a closed-loop system in which billions of vessels interact with each other, and it enables the control of the systemic arterial pressure and varying organ flow through autoregulatory mechanisms...
- Adipokines and the cardiovascular system: mechanisms mediating health and diseaseJosette M Northcott
Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, Canada
Can J Physiol Pharmacol 90:1029-59. 2012This review focuses on the role of adipokines in the maintenance of a healthy cardiovascular system, and the mechanisms by which these factors mediate the development of cardiovascular disease in obesity...
- Dysregulation of connexins and inactivation of NFATc1 in the cardiovascular system of Nkx2-5 null mutantsLaurent Dupays
Laboratoire de Génétique et Physiologie du Développement UMR CNRS 6545, Institut de Biologie du Developpement de Marseille, Universite de la Mediterranee, 13288 Marseille Cedex 9, France
J Mol Cell Cardiol 38:787-98. 2005..To evaluate this correlation, the expression of Cxs has been investigated in the cardiovascular system of wild-type and Nkx2-5-/- 9.2 days post-conception (dpc) mouse embryos...
- Sphingosine-1-phosphate signaling and biological activities in the cardiovascular systemYoh Takuwa
Department of Physiology, Kanazawa University Graduate School of Medicine, 13 1 Takara machi, Kanazawa, Ishikawa 920 8640, Japan
Biochim Biophys Acta 1781:483-8. 2008..These results provide evidence for S1P receptor subtype-specific pharmacological intervention as a novel therapeutic approach to cardiovascular diseases and cancer...
- Hypoxia-inducible factor and the development of stem cells of the cardiovascular systemD L Ramirez-Bergeron
Abramson Family Cancer Research Institute, Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
Stem Cells 19:279-86. 2001..to our understanding of the role hypoxia plays during early embryonic development in general and the cardiovascular system in particular...
- Comparison of the toxicity of silver, gold and platinum nanoparticles in developing zebrafish embryosP V AshaRani
Department of Chemistry, National University of Singapore, Singapore
Nanotoxicology 5:43-54. 2011..The toxic effects exhibited by the zebrafish embryos as a consequence of nanoparticle exposure, accompanied by the accumulation of metals inside the body calls for urgent further investigations in this field...
- Modifications of the cardiovascular system with agingAlberto U Ferrari
Cardioriabilitazione, Ospedale di Seregno, Az Osp Vimercate MI, Centro di Fisiologia Clinica e Ipertensione, Universita di Milano Bicocca, Via F Sforza, 35, 20122 Milan, Italy
Am J Geriatr Cardiol 11:30-3. 2002..Arterial baroreceptor control of blood pressure is largely preserved in advanced age, whereas cardiopulmonary-mediated reflex responses are definitely impaired...
- Autophagy in the cardiovascular systemGuido R Y De Meyer
Division of Pharmacology, University of Antwerp, Universiteitsplein 1, B 2610 Antwerp, Belgium
Biochim Biophys Acta 1793:1485-95. 2009....
- Insulin-like growth factor-2 regulates early neural and cardiovascular system development in zebrafish embryosLori Hartnett
Department of Biochemistry, National University of Ireland, Galway, Ireland
Int J Dev Biol 54:573-83. 2010..in ventralised embryos with reduced growth, reduced eyes, disrupted brain structures and a disrupted cardiovascular system, with igf-2b playing a more significant role in development...
- Matricryptic sites control tissue injury responses in the cardiovascular system: relationships to pattern recognition receptor regulated eventsGeorge E Davis
Department of Medical Pharmacology and Physiology, University of Missouri School of Medicine, Columbia, MO 65212, USA
J Mol Cell Cardiol 48:454-60. 2010This review addresses new concepts related to the importance of how cells within the cardiovascular system respond to matricryptic sites generated from the extracellular matrix (ECM) following tissue injury...
- Value of a cardiovascular limited ultrasound examination using a hand-carried ultrasound device on clinical management in an outpatient medical clinicBruce J Kimura
Scripps Mercy Hospital, San Diego, California, USA
Am J Cardiol 100:321-5. 2007..In conclusion, when applied to a clinic population, brief cardiovascular ultrasound exams frequently demonstrate unsuspected findings that can change management...
- Hydrogen sulfide and oxygen sensing in the cardiovascular systemKenneth R Olson
Indiana University School of Medicine, South Bend Center, South Bend, Indiana 46617, USA
Antioxid Redox Signal 12:1219-34. 2010..These studies also indicate that, under normoxic conditions, it is doubtful that free H(2)S has longer than a transient existence in tissue or extracellular fluid...
- Beneficial effect of low ethanol intake on the cardiovascular system: possible biochemical mechanismsSudesh Vasdev
Discipline of Medicine, Faculty of Medicine, Memorial University of Newfoundland, Health Sciences Centre, St John s, Newfoundland, Canada
Vasc Health Risk Manag 2:263-76. 2006..In conclusion, we suggest that chronic low ethanol intake confers its beneficial effect mainly through its ability to increase antioxidant capacity and lower AGEs...
- Hydrogen sulfide as a new endogenous gaseous transmitter in the cardiovascular systemChaoshu Tang
Institute of Cardiovascular Research, Peking University First Hospital, Beijing, People s Republic of China
Curr Vasc Pharmacol 4:17-22. 2006..The genomic basis of cystathioninuria in humans is 2 nonsense and 2 sense mutations in CSE. This review reveals that H(2)S is a new endogenous gaseous transmitter in the cardiovascular system.
- Numerical simulation of cardiovascular dynamics with different types of VAD assistanceYubing Shi
Department of Engineering, Queen Mary, University of London, London, UK
J Biomech 40:2919-33. 2007..Similarly, three pumping modes are modelled: constant flow; counterpulsation and copulsation. The cardiovascular system is modelled using an approach developed previously, using the concentrated parameter method by considering ..
- Periconceptional nutrition programs development of the cardiovascular system in the fetal sheepL J Edwards
Department of Physiology, University of Adelaide, Adelaide SA 5005, South Australia
Am J Physiol Regul Integr Comp Physiol 283:R669-79. 2002It has been proposed that fetal adaptations to intrauterine nutrient deprivation permanently reprogram the cardiovascular system. We investigated the impact of restricted periconceptional nutrition and/or restricted gestational nutrition ..
- Landmarks in understanding the central nervous control of the cardiovascular systemJohn H Coote
Division of Neuroscience, The Medical School, University of Birmingham, Birmingham B15 2TT, UK
Exp Physiol 92:3-18. 2007..Lecture I have tried to trace the key experiments that have developed ideas on how the brain regulates the cardiovascular system. It is a personal view and inevitably, owing to constraints on space and time, I have not been able to ..
- Effects of tetrodotoxin on the mammalian cardiovascular systemThomas Zimmer
Institute of Physiology II, Friedrich Schiller University, Kollegiengasse 9, 07743 Jena, Germany
Mar Drugs 8:741-62. 2010..Altogether, these data strongly suggest that TTX sensitive Na+ channels, detected more recently in various heart tissues, are not involved in excitation phenomena in the healthy adult heart of higher mammals...
- NO/redox disequilibrium in the failing heart and cardiovascular systemJoshua M Hare
Johns Hopkins University School of Medicine, Department of Medicine, Cardiology Division, Baltimore, Maryland 21205, USA
J Clin Invest 115:509-17. 2005..tree, which contribute to the abnormal cardiac and vascular phenotypes that characterize the failing cardiovascular system. These derangements at the integrated system level can be interpreted at the cellular and molecular levels ..
- Omega-3 fatty acids and cardiovascular diseaseClemens von Schacky
Preventive Cardiology, Medizinische Klinik und Poliklinik Innenstadt, Ludwig Maximilians Universitat Munchen, Munich, Germany
Curr Opin Clin Nutr Metab Care 10:129-35. 2007..EPA and DHA have advanced from scientific research into everyday practice, a development reviewed here...
- Thioredoxin in the cardiovascular systemCameron J World
Cardiovascular Research Institute, Department of Medicine, University of Rochester, Rochester, NY, USA
J Mol Med (Berl) 84:997-1003. 2006..TRX and its endogenous regulators may represent important future targets to develop clinical therapies for diseases associated with oxidative stress...
- Proprotein convertases: lessons from knockoutsNathalie Scamuffa
INSERM U716 Equipe AVENIR, Institut de Genetique Moleculaire, 27 rue Juliette Dodu, 75010 Paris, France
FASEB J 20:1954-63. 2006....
- Development of a mathematical model of the human circulatory systemMartin J Conlon
Department of Mechanical and Aerospace Engineering, Carleton University, 1125 Colonel By Drive, Ottawa, ON, K1S 5B6, Canada
Ann Biomed Eng 34:1400-13. 2006..The mathematical model produces reasonable systemic pressure and flow behaviour, and graphs of this data are included...
- Sex hormones and the cardiovascular system: effects on arterial function in womenH J Teede
The Jean Hailes Foundation for Women s Health, Monash Institute for Health Services Research and Diabetes Unit, Southern Health, Melbourne, Victoria, Australia
Clin Exp Pharmacol Physiol 34:672-6. 2007..The data on arterial function reviewed herein, along with emerging interventional human studies, suggest that the cardiovascular effects of this practice are not adverse...
- Acute effects of fine particles on cardiovascular system: differences between the spontaneously hypertensive rats and wistar kyoto ratsJinzhuo Zhao
Department of Environment Health, School of Public Health, Fudan University, Shanghai, China
Toxicol Lett 193:50-60. 2010..The results indicated that ambient fine particles which entered into lungs could influence the cardiovascular system. When exposed to fine particles, SHR exhibited more severe cardiovascular injury in comparison to WKY rats...
- Cardiovascular effects of beta-agonists in patients with asthma and COPD: a meta-analysisShelley R Salpeter
Santa Clara Valley Medical Center, San Jose, CA, USA
Chest 125:2309-21. 2004..beta(2)-Agonist use in patients with obstructive airway disease has been associated with an increased risk for myocardial infarction, congestive heart failure, cardiac arrest, and acute cardiac death...
- Alcohol and the cardiovascular system: research challenges and opportunitiesDiane L Lucas
Division of Metabolism and Health Effects, National Institute on Alcohol Abuse and Alcoholism NIH, Bethesda, MD, USA
J Am Coll Cardiol 45:1916-24. 2005..National Heart, Lung, and Blood Institute sponsored a state-of-the-art workshop on "Alcohol and the Cardiovascular System: Research Challenges and Opportunities" in Bethesda, Maryland, in May 2003...
- The complex pattern of SMAD signaling in the cardiovascular systemGerhild Euler-Taimor
Physiologisches Institut, Justus Liebig Universitat Giessen, Aulweg 129, 35392 Giessen, Germany
Cardiovasc Res 69:15-25. 2006..On the other hand, activation of SMADs by TGFbeta family members results in fibrotic, apoptotic, and anti-hypertrophic processes that are related to a detrimental cardiac remodeling and progression to heart failure...
- Multipotent flk-1+ cardiovascular progenitor cells give rise to the cardiomyocyte, endothelial, and vascular smooth muscle lineagesSteven J Kattman
Department of Gene and Cell Medicine, The Black Family Stem Cell Institute, Mount Sinai School of Medicine, New York, New York 10029, USA
Dev Cell 11:723-32. 2006..Isolation and characterization of this previously unidentified population suggests that the mammalian cardiovascular system develops from multipotential progenitors.
- Blockade of 5-HT2A receptors suppresses hyperthermic but not cardiovascular responses to psychosocial stress in ratsM I Beig
School of Biomedical Sciences, University of Newcastle, Callaghan, NSW 2038, Australia
Neuroscience 159:1185-91. 2009....
- Short-term complexity of cardiac autonomic control during sleep: REM as a potential risk factor for cardiovascular system in agingAntoine U Viola
Centre for Chronobiology, University of Basel, Basel, Switzerland
PLoS ONE 6:e19002. 2011..The aim of our study was to evaluate the HRV complexity using two entropy-derived measures, Shannon Entropy (SE) and Corrected Conditional Entropy (CCE), during sleep in young and older subjects...
- A multiformalism and multiresolution modelling environment: application to the cardiovascular system and its regulationAlfredo I Hernandez
INSERM, U642, Rennes 35000, France
Philos Trans A Math Phys Eng Sci 367:4923-40. 2009..The pioneering model of the overall regulation of the cardiovascular system proposed by Guyton and co-workers in 1972 has been implemented under M2SL and a pulsatile ventricular ..
- Efficient implementation of non-linear valve law and ventricular interaction dynamics in the minimal cardiac modelC E Hann
Department of Mechanical Engineering, University of Canterbury, Private Bag 4800, Christchurch, New Zealand
Comput Methods Programs Biomed 80:65-74. 2005..More specifically, a short 20-beat simulation that took 102 s now requires 4.3 s, significantly improving the model's potential for practical use in a diagnostic and/or decision support role in the intensive care unit...
- Prenatal high salt programs enhanced sympathoadrenal activation of the cardiovascular response to restraintJames P Porter
Department of Physiology and Developmental Biology, Brigham Young University, Provo, UT 84602, USA
Auton Neurosci 150:140-3. 2009..These data suggest that the prenatal high salt programmed a sympathoadrenal hyperresponsiveness to restraint stress...
- Coenzyme q10 confers cardiovascular protection against acute mevinphos intoxication by ameliorating bioenergetic failure and hypoxia in the rostral ventrolateral medulla of the ratDavid H T Yen
Department of Emergency Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, Republic of China
Shock 23:353-9. 2005....
- Multi-scale modeling of the human cardiovascular system with applications to aortic valvular and arterial stenosesFuyou Liang
Computational Science Research Program, RIKEN, Wako, Saitama, Japan
Med Biol Eng Comput 47:743-55. 2009A computational model of the entire cardiovascular system is established based on multi-scale modeling, where the arterial tree is described by a one-dimensional model coupled with a lumped parameter description of the remainder...
- Comparative analysis of methods for classifying the cardiovascular system's states under stressV S Anishchenko
Radiophysics and Nonlinear Dynamics Department, Saratov State University, Russia
Crit Rev Biomed Eng 29:462-81. 2001..This analysis was carried out by using standard nonlinear-dynamics algorithms and methods. Apart from that, we assessed the expediency of using a number of characteristics to classify the cardiovascular system's state under stress.
- Steroid hormones and the cardiovascular system: direct actions of estradiol, progesterone, testosterone, gluco- and mineralcorticoids, and soltriol [vitamin D] on central nervous regulatory and peripheral tissuesW E Stumpf
Department of Cell Biology and Anatomy, University of North Carolina, Chapel Hill 27599
Experientia 46:13-25. 1990..These data indicate that all steroid hormones exert direct actions on the cardiovascular system at its different levels of organization, thus enabling adjustment to the changing demands during ..
- Simulation of hemodynamic responses to the valsalva maneuver: an integrative computational model of the cardiovascular system and the autonomic nervous systemFuyou Liang
Graduate School of Science and Technology, Chiba University, Chiba, Japan
J Physiol Sci 56:45-65. 2006..In the present study, a computational model of the cardiovascular system (CVS) and its interaction with the autonomic nervous system (ANS) was developed for the purpose of ..
- Nongenomic effects of mineralocorticoid receptor activation in the cardiovascular systemAnastasia S Mihailidou
Department of Cardiology, Royal North Shore Hospital, University of Sydney, Sydney 2065, Australia
Steroids 70:347-51. 2005....
- Pharmacogenomics of drugs affecting the cardiovascular systemGerard Siest
INSERM U 525, Centre du Medicament, Faculte de Pharmacie, Universite Henri Poincare Nancy I, Nancy, France
Clin Chem Lab Med 41:590-9. 2003..From the risk concept emphasizing impaired metabolism and adverse effects, we now moved to an approach, which is a personalized, genotype-dependent adaptation of therapy...
- ORGANIZATION OF CENTRAL SYMPATHETIC PATHWAYSPatrice G Guyenet; Fiscal Year: 2013..These issues are paramount to understanding the effects of hypoxia on the cardiovascular system and the pathology of OSA, particularly the hypertension associated with this disease...
- Maternal obesity depresses essential fatty acid transport in the placentaPERRIE F O'TIERNEY-GINN; Fiscal Year: 2012..She has gained expertise in fetal physiology (especially of the cardiovascular system) and is well-versed in the literature surrounding the developmental origins of health and cardiovascular ..
- A novel peroxidase in vascular endothelium and the development of atherosclerosisGuangjie Cheng; Fiscal Year: 2012..aim is to understand why atherosclerosis, also known as the "hardening of blood vessels," occurs in cardiovascular system. It is clear that chemical change of low density lipoprotein (LDL), which contains "bad cholesterol," is ..
- Maternal obesity depresses essential fatty acid transport in the placentaPERRIE F O'TIERNEY-GINN; Fiscal Year: 2013..She has gained expertise in fetal physiology (especially of the cardiovascular system) and is well-versed in the literature surrounding the developmental origins of health and cardiovascular ..
- A Rodent Model to Study Links Among Diet, Visceral Adipose and CardiomyopathyMELINDA ANN FRYE; Fiscal Year: 2013..Additionally, Dr. Frye's clinical and research interest in the cardiovascular system is longstanding, and her investigations focused on disease attributed to obesity demonstrate a commitment ..
- Development of a Porcine Model of AtherosclerosisChristopher Rogers; Fiscal Year: 2010..In contrast to mice, the physiology and anatomy of the porcine cardiovascular system closely resembles that of humans...
- Effects of GSH +/- Arginine on Markers of Inflammation Among Adults with CVD RiskChristopher D Gardner; Fiscal Year: 2010..of observational and experimental studies have shown that an inflammatory oxidative environment in the cardiovascular system can lead to pathologic changes in the endothelium and contribute to atherosclerosis...
- Development of a Porcine Model of AtherosclerosisChristopher Rogers; Fiscal Year: 2012..In contrast to mice, the physiology and anatomy of the porcine cardiovascular system closely resembles that of humans...
- Role of ciliary proteins in endothelial cells morphogenesisCarlo Iomini; Fiscal Year: 2010..Both, CMG-1 and PC1 are expressed in the embryonic cardiovascular system and are upregulated during capillary morphogenesis...
- Predicting persistent Organ Failure early in Acute PancreatitisGeorgios I Papachristou; Fiscal Year: 2013..persistent organ failure, which is defined as persisting for 48 or more hours and involves the cardiovascular system, the pulmonary system, and/or the kidneys...
- Autoimmunity in the Mediation of Infectious MyocarditisJay Reddy; Fiscal Year: 2013..The long-term goal is to determine the autoimmune mechanisms of pathogens that commonly infect the cardiovascular system and initiate heart autoimmunity...
- Pathogenesis of autoimmune endocarditis: roles for Fc receptors and integrins?Bryce Binstadt; Fiscal Year: 2012..provided by applicant): Many systemic autoimmune diseases affect both the synovial joints and the cardiovascular system. For example, patients with rheumatoid arthritis or systemic lupus erythematosus (SLE) are at increased ..
- Regulation Of Inorganic Phosphorus (Pi) Metabolism By EstrogenHassane Amlal; Fiscal Year: 2013..an important and efficient therapeutic tool that can prevent hyperphosphatemia and its adverse effects on cardiovascular system in conditions associated with parathyroid gland dysfunction...
- A PROOF-OF-CONCEPT CLINICAL TRIAL OF XENIN-25 IN THE TREATMENT OF TYPE 2 DIABETESBurton M Wice; Fiscal Year: 2010..Efficacy is frequently short lived and potentially serious side effects particularly in the cardiovascular system have been reported...
- Endogenous Cardiac Glycosides in AASKBrad C Astor; Fiscal Year: 2010..These hormones are significantly higher in persons with CKD, and may have effects on the cardiovascular system through several different pathways...
- Endothelial SK3 Channel Modulation of EDHF is Estrogen RegulatedMike T Lin; Fiscal Year: 2011..applicant): Physiological changes including menopause and ovariectomy induce irreversible changes in the cardiovascular system that frequently result in diminished endothelium-dependent regulation of vascular tone and can lead to ..
- Crosstalk between estrogen and bile acid signaling pathwayRuitang Deng; Fiscal Year: 2013..estrogen exerts a vast range of biological effects in nonclassical endocrine organ systems, such as cardiovascular system and liver...
- Purinergic signaling in sleep apneaElzbieta Kaczmarek; Fiscal Year: 2012..The mechanisms by which OSA affects the cardiovascular system may result from excursions in intrathoracic pressure, increased sympathetic activation, and subsequent ..
- Release of FGF1 and Pathology of AngiogenesisIgor Prudovsky; Fiscal Year: 2010..FGF1 is a potent pro-angiogenic growth factor which participates in the development of cardiovascular system, its maintenance and response to damage...
- Cell Death in Alcoholic Heart and MuscleEmanuel Rubin; Fiscal Year: 2013..Stress and Tissue Injury Unit at NIAAA, who is a leader in research of oxidative/nitrosative stress in the cardiovascular system. Thus, the PIs'experience in calcium and Bcl-2 family protein-mediated mitochondrial stress and the ..
- Role of nuclear receptors in origin and differentiation of spermatozoaADAM MICHAEL REITZEL; Fiscal Year: 2011..superfamily, have pleiotropic roles in embryogenesis including roles in development of the nervous and cardiovascular system and in cancer due to expression in various embryonal carcinoma cell lines...
- Keratin biomaterial-based fluid for trauma resuscitationLUKE BURNETT; Fiscal Year: 2010..effect by bringing more fluid into the circulation without instigating adverse interactions within the cardiovascular system, [Preclinical] blood and tissues...
- Self-Sensing Physiologic Control of a Rotary Mag Lev LVADJAMES FARLEY WALTON; Fiscal Year: 2010..algorithms and system physical changes can be simulated including replacing the MCS model with a human cardiovascular system model...
- CELLULAR AND MOLECULAR BASES FOR RHYTHMIC GNRH RELEASESuzanne M Moenter; Fiscal Year: 2013..alter development and function of many systems, for example, bone, the central nervous system and the cardiovascular system. Episodic release of gonadotropin-releasing hormone (GnRH) is required for fertility in all vertebrates of ..
- NOVEL APPROACHES FOR REGULATION OF IGF-1 LEVELS THROUGHOUT THE LIFESPANWilliam Edmund Sonntag; Fiscal Year: 2013..are numerous studies that have reported beneficial effects of GH and/or IGF-1 replacement on the aging cardiovascular system and an overwhelming database indicating beneficial effects of these hormones on the aging brain...
- Obesity, vascular inflammation, and immune cell activation in prehypertensionSuzi Hong; Fiscal Year: 2013..challenge and Trier Social Stress Test are reliable and robust stress paradigms to investigate immune and cardiovascular system responses under neuroendocrine activation...
- Mechanisms of Cardiac Afferents and CNS Reflex ProcessingJohn C Longhurst; Fiscal Year: 2013..Additional knowledge derived from these studies will allow a better understanding of the mechanisms underlying the genesis of angina pectoris and reflex activation of the cardiovascular system during myocardial ischemia and reperfusion.
- Ozone Cardiovascular Effects in Genetically Susceptible PeopleMARK WALTER FRAMPTON; Fiscal Year: 2012..in deaths from cardiovascular disease, but we know little about how ozone air pollution affects the cardiovascular system. Our proposed studies will determine the effects of ozone on blood vessel and heart function that could ..
- Clinical Trail to Reverse Early Arterial StiffeningKim Sutton Tyrrell; Fiscal Year: 2010..effects that lead to increases in blood pressure and arterial stiffness and a premature aging of the cardiovascular system. This leads eventually to chronic hypertension, heart failure and cardiovascular mortality...
- Nitroso/redox balance in myocardial infarctionJoshua M Hare; Fiscal Year: 2013..oxide (NO), a highly versatile signaling molecule, exerts a broad range of regulatory influences in the cardiovascular system that extend from endothelial relaxation to platelet function, myocardial contractility, Ca2+ cycling, and ..
- Vagal afferent cell bodies as sensors of blood-borne factorsSTEPHEN JOHN LEWIS; Fiscal Year: 2010..This unique response mechanism may be vital in helping the body to defend the cardiovascular system against disease states that threaten human health such as high blood pressure, inflammation and diabetes.
- Human Pluripotent Stem Cell and Progenitor Models of Cardiac and Blood DiseasesLEONARD IRA ZON; Fiscal Year: 2013..into relevant tissues, and in disease modeling in two major systems of central interest to the NHLBI-the cardiovascular system and the blood...
- Myoglobin as a Nitrite Reductase that Regulates Hypoxic Cardiac NO SignalingSruti Shiva; Fiscal Year: 2013..the biological function of myoglobin and the physiological and pharmacological potential of nitrite in the cardiovascular system. PUBLIC HEALTH RELEVANCE: After a heart attack, part of the tissue in the heart dies...
- PHOSPHORYLATION AND ENDOTHELIAL NITRIC OXIDE PRODUCTIONWilliam C Sessa; Fiscal Year: 2013..macrovascular (atheroprotection) and microvascular (angiogenesis and permeability) functions in the cardiovascular system. As a corollary to this hypothesis, we predict that modulating eNOS phosphorylation will delay ..
- The roles of primary cilia in cardiovascular systemSURYA NAULI; Fiscal Year: 2012....
- Endothelial NOS by protein to protein interactionsWilliam C Sessa; Fiscal Year: 2013Endothelium-derived nitric oxide (NO) is a critical mediator of diverse functions in the cardiovascular system. During the tenure of this grant, we have developed the concept that eNOS inactivation/activation can be regulated by its ..
- Intrauterine hypoxia induces cytokine gene expression in fetal cardiac ventriclesLASHAUNA C EVANS; Fiscal Year: 2010..Adaptation of the fetal cardiovascular system to hypoxic stress is essential for survival...
- Development of a radioligand for assay of angiotensin-converting enzyme-2(ACE-2)ROBERT CHARLES SPETH; Fiscal Year: 2013..Ang II receptor subtype to cause pressor, fibrotic, mitogenic, and inflammatory responses that damage the cardiovascular system as well as susceptible target organs, e.g. kidney, heart and brain...
- Aging and Myocardial Progenitor RecruitmentRichard T Lee; Fiscal Year: 2013DESCRIPTION (provided by applicant): Aging of the cardiovascular system is characterized by a reduction in cardiac function, and cardiovascular disease frequently strikes in the latter half of life...
- Chlorinated Lipids in Myocardial Ischemia/ReperfusionDavid A Ford; Fiscal Year: 2013..Plasmalogens are a predominant phospholipid subclass in tissues of the cardiovascular system. Based on the discovery that activated neutrophils initiate the accumulation of a family of chlorinated ..
- Direct and Bone-Marrow Mediated Effects of Adipose Stem Cells in EmphysemaIrina Petrache; Fiscal Year: 2013..of airspaces, but also associated with systemic effects on organs that include the bone marrow and the cardiovascular system. Little is known about the mechanisms of systemic illness in emphysema and their impact, if any, on the ..
- Disordered Mineral Metabolism in the CKiD Children: Role of FGF-23Anthony A Portale; Fiscal Year: 2013..by applicant): Childhood and dolescence are crucial times for the development of a healthy skeletal and cardiovascular system. Chronic kidney disease (CKD) in youth results in metabolic bone disease, resultant growth failure and ..
- Model Systems for PXEJouni Uitto; Fiscal Year: 2013..PXE), the paradigm of heritable aberrant mineralization disorders, manifesting in the skin, eyes, and the cardiovascular system with considerable morbidity and mortality...
- PGC1alpha and Irisin in the Control of Diabetes and ObesityBruce M Spiegelman; Fiscal Year: 2013..2 diabetes, but they are still inadequate to prevent the negative effects of the Metabolic Syndrome on the cardiovascular system, cancer and other disorders...
- PPAR-gamma and Vascular Lesion FormationYuqing Eugene Chen; Fiscal Year: 2013..Thus, the investigation of the molecular mechanisms underlying PPAR-? functions especially in the cardiovascular system are of utmost importance...
- INTEGRATIVE NEUROBIOLOGY OF CARDIOVASCULAR REGULATIONFrancois M Abboud; Fiscal Year: 2012..Mark, Rahmouni) will address the coupling of the two major components of neurohumoral drive to the cardiovascular system, namely the sympathetic nervous system and the renal-angiotension-aldosterone system in as determinants of ..
- Regulation of Borealin Function by Mitotic PhosphorylationWilliam Taylor; Fiscal Year: 2009..Increased proliferation of fibroblasts and smooth muscle cells has also been implicated in diseases of the cardiovascular system, and knowing how Borealin is regulated may also provide insight into this spectrum of diseases.
- Role of Ubiquitin in Cardiovascular SystemSong Li; Fiscal Year: 2013..1 ..
- CNS AUTONOMIC PATHWAYS: CENTRAL CARDIOVASCULAR CONTROLArthur D Loewy; Fiscal Year: 2012..The studies presented here deal with the brain circuits controlling salt intake, and will provide new insights into the brain pathways which control sodium balance and ultimately, central regulation of the cardiovascular system.
- NEUROFIBROMIN, NEURAL CREST AND CARDIAC DEVELOPMENTJonathan A Epstein; Fiscal Year: 2012..competing renewal application to support our ongoing work to explore the function of neurofibromin in the cardiovascular system. Neurofibromin is encoded by the NF1 gene, which is mutated in von Recklinghausen Neurofibromatosis, a ..
- Cellular physiology of epilepsy-associated KCNQ2 channelsANASTASIOS TZINGOUNIS; Fiscal Year: 2013..Most family members are required for proper function of either the nervous or cardiovascular system as loss of function mutations in Kcnq genes lead to LQTS syndrome (Kcnq1), progressive hearing loss (Kcnq4)..
- Role of CYP P450s in the Regulation of Vascular Tone through Adenosine ReceptorsS Jamal Mustafa; Fiscal Year: 2013..acid (AA)-derived metabolites (EETs &20-HETE) through CYP450s have emerged as important mediators in cardiovascular system. However, the relationship between AR's and these metabolites in the regulation of VT is not well ..
- Identification of a Stretch-Activated Channel with a Role in Cardiac DevelopmentDipayan Chaudhuri; Fiscal Year: 2013..PUBLIC HEALTH RELEVANCE: The ability of the cardiovascular system to sense blood pressure and flow is central to its normal function, becoming altered in diseases such as ..
- Dual Function of VPO1 in Pathogen Recognition and KillingGuangjie Cheng; Fiscal Year: 2013..VPO1 is highly expressed in the cardiovascular system, lung, liver, pancreas and spleen, and is secreted into bloodstream at a 1000-fold higher concentration ..
- Regulation of GPER-mediated Signaling in the Vasculature by CalmodulinKim Tran; Fiscal Year: 2012..goal is to understand the mechanisms of action and roles of GPER in CaM- dependent activities in the cardiovascular system. Data from these studies will enhance our understanding of how estrogen works and provide timely ..
- Internalization of S. mutans in vascular endothelial cellsAnn Progulske-Fox; Fiscal Year: 2013..The commonality of these diseases is that they are diseases of the cardiovascular system. The ability of a pathogen to attach to and invade endothelial tissues has previously been shown to be ..
- Mechanisms of ROS Balance and Cardiac Energy Metabolism in Diabetes MellitusSONIA DEL CARMEN CORTASSA; Fiscal Year: 2012..in order to perform a rational intervention in the treatment and prevention of a disease regarding the cardiovascular system, a deeper understanding of the integrated behavior of metabolic networks is needed...
- Imaging Nonlinear Control of the Pulmonary Circulation with Proton MRISusan R Hopkins; Fiscal Year: 2013..and was lost in brain death suggesting that nonlinear control is a critical feature of a healthy human cardiovascular system. Nonlinear forecasting yields a set of metrics that provide information on the type of nonlinear ..
- Endothelial BK Channel Regulation by Caveolae TargetingHon Chi Lee; Fiscal Year: 2010The overall objective of our research program is to understand the regulation of ion channels in the cardiovascular system. We made a novel observation that the large conductance Ca2+-activated K+ (BK) channels are targeted to caveolae ..
- Short-Term Institutional Research Training GrantMarlys Hearst Witte; Fiscal Year: 2013..Centers of Excellence focusing on in vivo, in vitro, in situ, in silico and modeling approaches to the cardiovascular system and its disorders (e.g...
- Regulation of Blood Pressure by KlothoZhongjie Sun; Fiscal Year: 2013..The results will provide novel mechanism that klotho protects the cardiovascular system. Completion of the project may reveal new insights into therapeutic strategies for hypertension and ..
- AUTONOMIC CARDIOVASCULAR REGULATIONDAVID HERLIE ROBERTSON; Fiscal Year: 2013..provided by applicant): The autonomic nervous system is the crucial link between the brain and the cardiovascular system. It is the final common pathway by which central disturbances - whether initiated by exogenous ..
- BAROREFLEX AND POSTERIOR HYPOTHALAMIC NEUROPEPTIDE-YJohn Martin; Fiscal Year: 1991..the cholinergic system of the posterior hypothalamic nucleus (PHN) plays a role in the regulation of the cardiovascular system by affecting autonomic nervous and endocrine systems...
- Y Receptor In and Cardiovascular Function From the PHNJohn Martin; Fiscal Year: 2004..to understand the relationship between NPY and acetylcholine in the PHN with respect to the control of the cardiovascular system. The hypothesis to be addressed is that NPY stimulates the Y1 receptor subtype within the PHN to activate ..
- Abcb11 and Hepatic TransportAnne Henkel; Fiscal Year: 2009..function in both normal physiology and in pathophysiologic diseases of the liver, biliary tract, and cardiovascular system. The rate-limiting step in bile salt transport is canalicular secretion, which is mediated by the bile ..