skull base

Summary

Summary: The inferior region of the skull consisting of an internal (cerebral), and an external (basilar) surface.

Top Publications

  1. ncbi Neuro-ophthalmologic manifestations of benign anterior skull base lesions
    Mark Hornyak
    Department of Neurosurgery, University of Utah, Salt Lake City, UT 84132, USA
    Postgrad Med 121:103-14. 2009
  2. ncbi Endoscopic endonasal skull base surgery: analysis of complications in the authors' initial 800 patients
    Amin B Kassam
    Department of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    J Neurosurg 114:1544-68. 2011
  3. pmc The natural evolution of endoscopic approaches in skull base surgery: robotic-assisted surgery?
    I Dallan
    Otorhinolaryngologic Unit, University of Insubria, Italy
    Acta Otorhinolaryngol Ital 31:390-4. 2011
  4. ncbi A novel reconstructive technique after endoscopic expanded endonasal approaches: vascular pedicle nasoseptal flap
    Gustavo Hadad
    Department of Otolaryngology Head and Neck Surgery, Medical School of Ciudad de Rosario, Provincia de Santa Fe, Republica Argentina
    Laryngoscope 116:1882-6. 2006
  5. ncbi Endoscopic skull base reconstruction of large dural defects: a systematic review of published evidence
    Richard J Harvey
    Department of Otolaryngology and Skull Base Surgery, St Vincent s Hospital, Sydney, New South Wales, Australia
    Laryngoscope 122:452-9. 2012
  6. pmc Skull base metastases from a malignant solitary fibrous tumor of the liver. A case report and literature review
    Lu Peng
    Department of General Surgery, Research Center of Digestive Diseases, Zhongnan Hospital, Wuhan University, PR China
    Diagn Pathol 6:127. 2011
  7. ncbi Tumefactive fibroinflammatory lesion of the neck with progressive invasion of the meninges, skull base, orbit, and brain
    A I Holodny
    Department of Radiology, New Jersey Medical School, University Hospital, 150 Bergen Street, Newark, NJ 07103, USA
    AJNR Am J Neuroradiol 22:876-9. 2001
  8. ncbi Nasoseptal flap reconstruction of high flow intraoperative cerebral spinal fluid leaks during endoscopic skull base surgery
    Adam M Zanation
    Department of Otolaryngology Head and Neck Surgery, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA
    Am J Rhinol Allergy 23:518-21. 2009
  9. ncbi Gamma knife surgery for skull base meningiomas
    Robert M Starke
    Department of Neurological Surgery, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    J Neurosurg 116:588-97. 2012
  10. ncbi Utility of novel 3-dimensional stereoscopic vision system for endoscopic sinonasal and skull-base surgery
    R Peter Manes
    Comprehensive Skull Base Program, Department of Otolaryngology Head and Neck Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Int Forum Allergy Rhinol 1:191-7. 2011

Detail Information

Publications295 found, 100 shown here

  1. ncbi Neuro-ophthalmologic manifestations of benign anterior skull base lesions
    Mark Hornyak
    Department of Neurosurgery, University of Utah, Salt Lake City, UT 84132, USA
    Postgrad Med 121:103-14. 2009
    Visual disturbance is a common presenting symptom of anterior skull base lesions. These lesions cause deterioration in visual acuity, restriction of the visual field, or reduction of ocular mobility...
  2. ncbi Endoscopic endonasal skull base surgery: analysis of complications in the authors' initial 800 patients
    Amin B Kassam
    Department of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    J Neurosurg 114:1544-68. 2011
    ..of endoscopic endonasal approaches, albeit in the early stages, represents part of the continuous evolution of skull base surgery...
  3. pmc The natural evolution of endoscopic approaches in skull base surgery: robotic-assisted surgery?
    I Dallan
    Otorhinolaryngologic Unit, University of Insubria, Italy
    Acta Otorhinolaryngol Ital 31:390-4. 2011
    ..This is particularly intriguing in skull base regions...
  4. ncbi A novel reconstructive technique after endoscopic expanded endonasal approaches: vascular pedicle nasoseptal flap
    Gustavo Hadad
    Department of Otolaryngology Head and Neck Surgery, Medical School of Ciudad de Rosario, Provincia de Santa Fe, Republica Argentina
    Laryngoscope 116:1882-6. 2006
    In patients with large dural defects of the anterior and ventral skull base after endonasal skull base surgery, there is a significant risk of a postoperative cerebrospinal fluid leak after reconstruction...
  5. ncbi Endoscopic skull base reconstruction of large dural defects: a systematic review of published evidence
    Richard J Harvey
    Department of Otolaryngology and Skull Base Surgery, St Vincent s Hospital, Sydney, New South Wales, Australia
    Laryngoscope 122:452-9. 2012
    Systematically review the outcomes of endoscopic endonasal techniques to reconstruct large skull base defects (ESBR)...
  6. pmc Skull base metastases from a malignant solitary fibrous tumor of the liver. A case report and literature review
    Lu Peng
    Department of General Surgery, Research Center of Digestive Diseases, Zhongnan Hospital, Wuhan University, PR China
    Diagn Pathol 6:127. 2011
    ..To our knowledge, this is the first case of malignant solitary fibrous liver tumors with skeletal metastasis...
  7. ncbi Tumefactive fibroinflammatory lesion of the neck with progressive invasion of the meninges, skull base, orbit, and brain
    A I Holodny
    Department of Radiology, New Jersey Medical School, University Hospital, 150 Bergen Street, Newark, NJ 07103, USA
    AJNR Am J Neuroradiol 22:876-9. 2001
    ..The lesion caused destruction of the skull base and a subdural hematoma...
  8. ncbi Nasoseptal flap reconstruction of high flow intraoperative cerebral spinal fluid leaks during endoscopic skull base surgery
    Adam M Zanation
    Department of Otolaryngology Head and Neck Surgery, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA
    Am J Rhinol Allergy 23:518-21. 2009
    ..The goals of this study are to prospectively evaluate the nasoseptal flap and high-risk cerebral spinal fluid (CSF) leak variables...
  9. ncbi Gamma knife surgery for skull base meningiomas
    Robert M Starke
    Department of Neurological Surgery, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    J Neurosurg 116:588-97. 2012
    b>Skull base meningiomas are challenging tumors owing in part to their close proximity to important neurovascular structures...
  10. ncbi Utility of novel 3-dimensional stereoscopic vision system for endoscopic sinonasal and skull-base surgery
    R Peter Manes
    Comprehensive Skull Base Program, Department of Otolaryngology Head and Neck Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Int Forum Allergy Rhinol 1:191-7. 2011
    The objective of this pilot study was to evaluate the utility of novel 3-dimensional (3D) endoscopy during endoscopic sinonasal and skull base surgery.
  11. ncbi Endoscopic surgery of the anterior skull base
    John D Casler
    Otolaryngology Head and Neck Surgery Service, Department of Surgery, Walter Reed Army Medical Center, Washington, DC 20307, USA
    Laryngoscope 115:16-24. 2005
    Traditional surgical approaches to the anterior skull base often involve craniotomy, facial incisions, disruption of skeletal framework, tracheotomy, and an extended hospital stay...
  12. ncbi Three-dimensional and 2-dimensional endoscopic exposure of midline cranial base targets using expanded endonasal and transcranial approaches
    Jonathan Roth
    Department of Neurological Surgery, Weill Medical College of Cornell University, New York Presbyterian Hospital, New York, New York 10021, USA
    Neurosurgery 65:1116-28; discussion 1128-30. 2009
    ..To integrate these approaches into neurosurgical practice, the extent of their anatomic exposure must be compared with that provided by more traditional transcranial approaches...
  13. ncbi Nasoseptal flap takedown and reuse in revision endoscopic skull base reconstruction
    Adam M Zanation
    Department of Otolaryngology Head and Neck Surgery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Laryngoscope 121:42-6. 2011
    ..a description of the techniques and limitations of nasoseptal flap takedown and reuse during second-stage and revision endoscopic skull base surgery and review the institutional experience with the use of this reconstructive technique.
  14. ncbi Cranial base growth in patients with Down syndrome: a longitudinal study
    Juan J Alio
    Prophylaxis, Odonthopediatrics and Orthodontics Department, Universidad Complutense de Madrid, Universidad Complutense de Madrid, Madrid, Spain
    Am J Orthod Dentofacial Orthop 133:729-37. 2008
    ..The purpose of this study was to assess the growth of the cranial base in a sample of patients diagnosed with Down syndrome (DS)...
  15. ncbi Reconstruction techniques in skull base surgery
    Filippo Gagliardi
    Department of Neurosurgery, San Raffaele Scientific Institute, Vita Salute University, Milan, Italy
    J Craniofac Surg 22:1015-20. 2011
    ..A variety of endoscopic pedicled mucosal flaps within the nasal cavity have also been described. The different reconstruction techniques are described and discussed in terms of indications, advantages, and drawbacks...
  16. ncbi Endoscopic pedicled nasoseptal flap reconstruction for pediatric skull base defects
    Rupali N Shah
    Department of Otolaryngology Head and Neck Surgery, University of North Carolina Hospitals, Chapel Hill, North Carolina 27599, USA
    Laryngoscope 119:1067-75. 2009
    ..radioanatomic analysis of computed tomography (CT) scans to determine limitations of the nasoseptal flap in pediatric skull base reconstruction and to describe clinical outcomes after using the nasoseptal flap in six pediatric patients.
  17. ncbi Long-term outcomes of fractionated stereotactic radiotherapy for intracranial skull base benign meningiomas in single institution
    Shunsuke Onodera
    Department of Radiation Medicine, Hokkaido University Graduate School of Medicine, North 15, West 7, Kita ku, Sapporo 060 8638, Japan
    Jpn J Clin Oncol 41:462-8. 2011
    ..the outcome of linac-based fractionated stereotactic radiotherapy over the last 10 years for intracranial skull base benign meningiomas in patients who were inoperable, who had residual tumors with some components of high mitotic ..
  18. ncbi Radiology of skull base neoplasms
    D D Durden
    Department of Radiology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA
    Otolaryngol Clin North Am 34:1043-64, vii. 2001
    Computed tomography (CT) and magnetic resonance (MR) imaging are used routinely to stage skull base neoplasms preoperatively, define the extent of the tumor, identify perineural spread, plan surgery and radiation therapy, and evaluate the ..
  19. ncbi Temporalis muscle flap for reconstruction of skull base defects
    Jesse E Smith
    Department of Otolaryngology Head and Neck Surgery, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Head Neck 32:199-203. 2010
    The temporalis muscle flap (TMF) is a valuable reconstructive technique utilized in a variety of challenging defects. However, its use for repair of skull base defects is less commonly reported.
  20. ncbi Fibrous dysplasia involving the skull base and temporal bone
    L R Lustig
    Department of Otolaryngology Head and Neck Surgery, The Johns Hopkins University, JHOC Sixth Floor, 601 N Caroline St, Baltimore, MD 21287 0910, USA
    Arch Otolaryngol Head Neck Surg 127:1239-47. 2001
    To gain a broader appreciation of the clinical presentation, operative treatment, and outcome of patients with fibrous dysplasia involving the skull base.
  21. ncbi Stereotactic proton beam therapy of skull base meningiomas
    F J Vernimmen
    Department of Radiation Oncology, Tygerberg Hospital, Tygerberg, South Africa
    Int J Radiat Oncol Biol Phys 49:99-105. 2001
    To review outcomes for patients with skull base meningiomas treated using the stereotactic proton beam at the National Accelerator Center (NAC), Republic of South Africa.
  22. ncbi Expanded endonasal approach: fully endoscopic, completely transnasal approach to the middle third of the clivus, petrous bone, middle cranial fossa, and infratemporal fossa
    Amin B Kassam
    Minimally Invasive Endoneurosurgical Center, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Neurosurg Focus 19:E6. 2005
    ..third of the clivus and the region around the petrous internal carotid artery (ICA) is a difficult area of the skull base in terms of access...
  23. ncbi A comparison of craniofacial morphology in patients with and without facial asymmetry--a three-dimensional analysis with computed tomography
    T G Kwon
    Department of Oral and Maxillofacial Surgery, School of Dentistry, Kyungpook National University, Samduck 2 Ga, Jung Gu, Daegu 700 421, South Korea
    Int J Oral Maxillofac Surg 35:43-8. 2006
    ..The asymmetric condyle position was found to be associated with skull base characteristics...
  24. ncbi Janus flap: bilateral nasoseptal flaps for anterior skull base reconstruction
    Gurston G Nyquist
    Department of Otorhinolaryngology, Weill Cornell Medical College, New York Presbyterian Hospital, New York, NY, USA
    Otolaryngol Head Neck Surg 142:327-31. 2010
    Large dural defects after extended endoscopic endonasal skull base resections require meticulous reconstruction to prevent a cerebrospinal fluid leak postoperatively...
  25. ncbi Practical and technical aspects of trans-sphenoidal surgery
    R Chamoun
    Department of Neurosurgery, University of Utah, Salt Lake City, UT, USA
    J Neurosurg Sci 55:265-75. 2011
    ..With enhanced knowledge and understanding of the surgical anatomy of the skull base, the application of extended transsphenoidal approaches became possible, thus widening significantly the ..
  26. ncbi Surgical resection of pediatric skull base meningiomas
    Jan Karl Burkhardt
    Department of Neurosurgery, University Hospital of Zurich, Frauenklinikstrasse 10, Zurich 8091, Switzerland
    Childs Nerv Syst 29:83-7. 2013
    Meningiomas in children are rare, especially those located at the skull base. In this study, we report our experience of meningioma surgery in the pediatric population and compare our findings of skull base (SB) versus non-skull base (NSB)..
  27. ncbi Osteoma of the skull base and sinuses
    Christos Georgalas
    Department of Otolaryngology, Endoscopic Skull Base Centre, Academic Medical Centre, Amsterdam, Meibergdreef 9, 1105 AZ, The Netherlands
    Otolaryngol Clin North Am 44:875-90, vii. 2011
    ..We believe that the vast majority of frontal sinus osteomata can be managed endoscopically, and that only significant anterior or extreme infero-lateral extension constitute major limiting factors...
  28. ncbi Anterior pedicle lateral nasal wall flap: a novel technique for the reconstruction of anterior skull base defects
    Gustavo Hadad
    Department of Otolaryngology Head and Neck Surgery, Medical School of Ciudad de Rosario, Provincia de Santa Fe, Republica Argentina
    Laryngoscope 121:1606-10. 2011
    ..We present the anatomic foundations of a novel anterior pedicled lateral wall flap (Hadad-Bassagaisteguy 2 or HB2 flap) for the vascularized reconstruction of anterior skull base defects.
  29. ncbi Premature craniosynostosis--the role of skull base surgery in its correction. A surgical and radiological experience of 172 operated infants/children
    B J Schaller
    University of Oradea, Romania
    J Craniomaxillofac Surg 40:195-200. 2012
    ..Functional impairment is caused either by a pathological growth pattern or increased intracranial pressure. The indications for surgery are to increase intracranial volume and to correct aesthetics...
  30. ncbi [Force-based local navigation in robot-assisted implantation bed anlage in the lateral skull base. An experimental study]
    P K Plinkert
    Klinik und Poliklinik für Hals Nasen Ohrenheilkunde, Universitatskliniken des Saarlandes, Homburg Saar
    HNO 50:233-9. 2002
    ..Our examinations showed a successful reaming of an implant bed in the lateral scull base with a robot. Because of a force controlled reaming process locale navigation is possible and enables careful thrilling with a robot...
  31. ncbi Analysis of prognostic factors in 146 patients with anterior skull base sarcoma: an international collaborative study
    Ziv Gil
    Department of Surgery, Head and Neck Service, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Cancer 110:1033-41. 2007
    ..power to assess the role of surgery and radiotherapy in the management of sarcomas involving the anterior skull base. For this study, an international collaborative study group analyzed a large cohort of patients who underwent ..
  32. ncbi The role of hair shaving in skull base surgery
    Ziv Gil
    Skull Base Surgery Unit, Department of Otolaryngology Head and Neck Surgery, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Israel
    Otolaryngol Head Neck Surg 128:43-7. 2003
    We sought to evaluate surgical wound infection rates in patients undergoing skull base surgery without hair removal.
  33. ncbi Salvage endoscopic nasoseptal flap repair of persistent cerebrospinal fluid leak after open skull base surgery
    Jean Anderson Eloy
    Department of Otolaryngology Head and Neck Surgery, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, USA
    Am J Otolaryngol 33:735-40. 2012
    Persistent cerebrospinal fluid (CSF) rhinorrhea after open skull base surgery can be challenging to manage due to the risk of meningitis, brain abscess, surgical morbidity associated with revision craniotomy, and the lack of available ..
  34. ncbi Diffusion MR imaging features of skull base osteomyelitis compared with skull base malignancy
    B Ozgen
    Department of Radiology, Hacettepe University, Ankara, Turkey
    AJNR Am J Neuroradiol 32:179-84. 2011
    ..SBO is a life-threatening infection that may have radiologic features similar to those of the neoplastic processes. The purpose of this study was to evaluate the DWI findings in SBO to facilitate the differential diagnosis...
  35. ncbi Tactile dysgeusia: a new clinical observation of middle ear and skull base surgery
    Joseph M Chen
    Department of Otolaryngology Head and Neck Surgery, University of Toronto, Sunnybrook Health Sciences Centre, M102 2075 Bayview Avenue, Toronto, Ontario, Canada
    Laryngoscope 118:99-103. 2008
    To describe a new clinical observation of "tactile dysgeusia," a phenomenon associated with otologic and skull base surgery likely caused by injury to the chorda tympani nerve (CTN) or the nervus intermedius (NI) with subsequent aberrant ..
  36. pmc Lateral approaches to the skull base
    E Zanoletti
    Otochirurgia Otorinolaringoiatria Az Ospedaliera Università di Padova, Padova, Italy
    Acta Otorhinolaryngol Ital 32:281-7. 2012
    Progress in the study of skull base anatomy and the different lesions involving it has led to more and more precise knowledge of the site...
  37. ncbi Ruptured internal carotid pseudoaneurysm in a nasopharyngeal carcinoma patient with skull base osteoradionecrosis
    Hsin Chien Chen
    Department of Otolaryngology Head and Neck Surgery, Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan
    Otolaryngol Head Neck Surg 130:388-90. 2004
  38. ncbi Extended endoscopic endonasal approach to the skull base
    O L Arbolay
    Department of Neurosurgery, Hermanos Ameijeiras Hospital, La Habana City, Cuba
    Minim Invasive Neurosurg 52:114-8. 2009
    Different approaches to the skull base have been developed through the sphenoidal sinus. Traditional boundaries of the trans-sphenoidal approach can be extended in antero-posterior and lateral planes...
  39. pmc Detecting plasma Epstein-Barr virus DNA to diagnose postradiation nasopharyngeal skull base lesions in nasopharyngeal carcinoma patients: a prospective study
    Fa Ya Liang
    Department of Head and Neck Surgery, Sun Yat Sen Memorial Hospital, Sun Yat Sen University, Guangzhou, Guangdong 510120, P R China
    Chin J Cancer 31:142-9. 2012
    The diagnosis of postradiation nasopharyngeal skull base lesions in petients with nasopharyngeal carcinoma (NPC) is still a tough problem in clinical practice. An early and accurate diagnosis is important for subsequent management...
  40. ncbi Important prognostic factors in patients with skull base erosion from nasopharyngeal carcinoma after radiotherapy
    T X Lu
    Department of Radiation Oncology, Cancer Center, Sun Yat-sen University of Medical Sciences, Guangzhou, People's Republic of China
    Int J Radiat Oncol Biol Phys 51:589-98. 2001
    PURPOSE: To evaluate the long-term outcome and prognostic factors in patients with skull base erosion from nasopharyngeal carcinoma after initial radiotherapy (RT)...
  41. ncbi Surgery on the lateral skull base with the navigated controlled drill employed for a mastoidectomy (pre clinical evaluation)
    M Hofer
    BMBF Innovation Center Computer Assisted Surgery ICCAS, University of Leipzig, Leipzig, Germany
    Stud Health Technol Inform 125:179-84. 2007
    ..Following results were received: 1. Risk structure segmentation is feasible 2. The drill and a phantom can be registered. 3. With NC the resection is faster, more accurate and with no risk structures damage. 4. The phantom is suitable...
  42. ncbi [Applications for a robot in the lateral skull base. Evaluation of robot-assisted mastoidectomy in an anatomic specimen]
    P K Plinkert
    Klinik und Poliklinik für Hals Nasen Ohrenheilkunde, Universitätskliniken des Saarlandes UKH, Kirrberger Strasse, 66421 Homburg Saar
    HNO 49:514-22. 2001
    ..Their site of implantation is localized in the lateral skull base. Removal of the bone mass with the reamer requires both great precision and considerable physical effort on the ..
  43. ncbi Bilateral traumatic abducens nerve palsy associated with skull base fracture--case report
    Makoto Katsuno
    Department of Emergency and Critical Care, Nippon Medical School, Tokyo
    Neurol Med Chir (Tokyo) 47:307-9. 2007
    A 29-year-old man presented with skull base fractures involving the bilateral petrous bones and clivus to the posterior clinoid process manifesting as bilateral abducens nerves palsy...
  44. ncbi The incidence of invasion and metastasis of nasopharyngeal carcinoma at different anatomic sites in the skull base
    Jun Han
    Department of Otorhinolaryngology Head and Neck Surgery, Xuanwu Hospital of Capital University of Medical Science, Beijing 100053, China
    Anat Rec (Hoboken) 295:1252-9. 2012
    ..incidence of direct invasion and metastasis of nasopharyngeal carcinoma (NPC) at different anatomic sites in the skull base using magnetic resonance imaging (MRI)...
  45. ncbi Endoscopic nasoseptal flap repair of skull base defects: is addition of a dural sealant necessary?
    Jean Anderson Eloy
    Department of Otolaryngology Head and Neck Surgery, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, New Jersey 07103, USA
    Otolaryngol Head Neck Surg 147:161-6. 2012
    We compared the incidence of postoperative cerebrospinal fluid (CSF) leaks in patients undergoing endoscopic skull base repair with a pedicled nasoseptal flap (PNSF) with or without the addition of a dural sealant.
  46. ncbi Malignant peripheral nerve sheath tumor in the anterior skull base associated with neurofibromatosis type 1--case report
    Ryo Ueda
    Department of Neurosurgery, Keio University School of Medicine, Tokyo, Japan
    Neurol Med Chir (Tokyo) 44:38-42. 2004
    A 36-year-old man presented with a tumor in the anterior skull base manifesting as headache and visual disturbance. Neurofibromatosis type 1 (NF-1) was identified in early childhood in the patient, and also in his father...
  47. ncbi Extended endoscopic endonasal skull base surgery: from the sella to the anterior and posterior cranial fossa
    Amanda Oostra
    Department of Neurosurgery, Slotervaart Hospital, Amsterdam, The Netherlands
    ANZ J Surg 82:122-30. 2012
    b>Skull base surgery has gone through significant changes with the development of extended endoscopic endonasal approaches over the last decade...
  48. ncbi Surgical nuances for nasoseptal flap reconstruction of cranial base defects with high-flow cerebrospinal fluid leaks after endoscopic skull base surgery
    James K Liu
    Department of Neurological Surgery, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jersey 07101, USA
    Neurosurg Focus 32:E7. 2012
    ..endonasal approaches have allowed for a minimally invasive solution for removal of a variety of ventral skull base lesions, including intradural tumors...
  49. ncbi High incidence of optic canal involvement in tuberculum sellae meningiomas: rationale for aggressive skull base approach
    Burak Sade
    Brain Tumor and Neuro Oncology Center, Neurological Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Surg Neurol 72:118-23; discussion 123. 2009
    ..Current literature on TSMs underemphasizes the significance of OCI by the tumor. In this study, we aimed to document the incidence of OCI, its management using a SBT, and its significance with relation to the visual outcome...
  50. ncbi Imaging of skull base cerebrospinal fluid leaks in adults
    Kristen M Lloyd
    Department of Radiology, Emory University School of Medicine, 1364 Clifton Rd NE, Atlanta, GA 30322, USA
    Radiology 248:725-36. 2008
    Cerebrospinal fluid (CSF) leak occurs when there is an osseous and dural defect at the skull base, with direct communication of the subarachnoid space to the extracranial space, usually a paranasal sinus...
  51. ncbi Digital volume tomography (DVT) as a diagnostic modality of the anterior skull base
    Martin Bremke
    Department of Otolaryngology, Head and Neck Surgery, Philipps University of Marburg, Germany
    Acta Otolaryngol 129:1106-14. 2009
    ..Because of high resolution and the relatively lower costs in comparison with modern helical CT scanners, digital volume tomography (DVT) can be recommended in the diagnosis of the nasal cavity and paranasal sinuses...
  52. ncbi Skull base reconstruction
    Mario J Imola
    Center for Craniofacial Skull Base Surgery, Denver, Colorado, USA
    Curr Opin Otolaryngol Head Neck Surg 11:282-90. 2003
    Reconstruction of skull base defects following tumor resection is of paramount importance in avoiding serious and life-threatening complications...
  53. ncbi Inflammatory pseudotumor of the cavernous sinus and skull base
    Todd McCall
    Department of Neurosurgery, University of Utah, 30 North 1900 East, Suite 3B409, Salt Lake City, UT, 84132, USA
    Neurosurg Rev 29:194-200. 2006
    ..These lesions are rapidly responsive to steroid therapy. Surgery is typically indicated for biopsy only, but complete resection may be justified for lesions outside the cavernous sinus...
  54. ncbi Prophylactic intravenous nimodipine treatment in skull base surgery: pharmacokinetic aspects
    C Scheller
    University of Halle Wittenberg, Department of Neurosurgery, Halle Saale, Germany
    J Neurol Surg A Cent Eur Neurosurg 73:153-9. 2012
    ..Nimodipine is primarily used in subarachnoid hemorrhage (SAH). Clinical trials revealed also a beneficial effect of prophylactic nimodipine treatment on cranial nerve functions following vestibular schwannoma surgery...
  55. ncbi Posterior pedicle lateral nasal wall flap: new reconstructive technique for large defects of the skull base
    Carlos M Rivera-Serrano
    Department of Otolaryngology Head and Neck Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Am J Rhinol Allergy 25:e212-6. 2011
    Indications for expanded endoscopic approaches continue to grow, resulting in larger and more complex skull base defects. Reconstructive developments, however, have lagged our extirpative capabilities...
  56. ncbi A controlled laboratory and clinical evaluation of a three-dimensional endoscope for endonasal sinus and skull base surgery
    Rupali N Shah
    Department of Otolaryngology Head and Neck Surgery, Department of Surgery, University of North Carolina Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Am J Rhinol Allergy 25:141-4. 2011
    ..Its clinical value was then evaluated during endoscopic sinus and skull base surgical cases.
  57. ncbi Pulsed laser-induced liquid jet for skull base tumor removal with vascular preservation through the transsphenoidal approach: a clinical investigation
    Yoshikazu Ogawa
    Department of Neurosurgery, Kohnan Hospital, Nagamachiminami, Taihaku ku, Sendai, Miyagi, Japan
    Acta Neurochir (Wien) 153:823-30. 2011
    ..To overcome these problems, we have developed a pulsed laser-induced liquid jet (LILJ) system to dissect tumor tissue with preservation of fine blood vessels within deep and narrow working spaces and evaluated its utility and safety...
  58. ncbi First clinical evaluation of the navigated controlled drill at the lateral skull base
    M Hofer
    BMBF Innovation Center Computer Assisted Surgery ICCAS, University of Leipzig, Germany
    Stud Health Technol Inform 132:171-3. 2008
    Surgery on the lateral skull base puts delicate structures at risk. To support the surgeon in identifying and protecting the risk structures the principle of Navigated Control (NC) can be used for preventing iatrogenic injuries...
  59. ncbi [Transnasal endoscopic approaches to the cranial base]
    Tomasz Lyson
    Klinika Neurochirurgii, Uniwersytet Medyczny w Białymstoku, Białystok
    Neurol Neurochir Pol 47:63-73. 2013
    ..The authors of this contribution use most of these approaches in their endoscopic skull base surgery...
  60. ncbi Computed tomography of the anterior skull base in Kallmann syndrome reveals specific ethmoid bone abnormalities associated with olfactory bulb defects
    Luigi Maione
    Universite Paris Sud, Faculte de Medecine Paris Sud, Assistance Publique Hopitaux de Paris, Hopital de Bicetre, Service d endocrinologie et des maladies de la reproduction, Le Kremlin Bicetre, France
    J Clin Endocrinol Metab 98:E537-46. 2013
    ..Kallmann syndrome (KS) is characterized by congenital hypogonadotropic hypogonadism (CHH) and an impaired sense of smell related to defective development of the olfactory system...
  61. ncbi Intraoperative facial nerve motor evoked potential monitoring during skull base surgery predicts long-term facial nerve function outcomes
    Masafumi Fukuda
    Department of Neurosurgery, Brain Research Institute, University of Niigata, Japan
    Neurol Res 33:578-82. 2011
    This study was designed to clarify whether facial nerve motor evoked potentials (FNMEPs) elicited by transcranial electrical stimulation during skull base surgery are useful for predicting long-term facial nerve function.
  62. ncbi World Health Organization Grades II and III meningiomas are rare in the cranial base and spine
    Burak Sade
    Brain Tumor Institute, The Cleveland Clinic, Cleveland, Ohio 44195, USA
    Neurosurgery 61:1194-8; discussion 1198. 2007
    ..This study was undertaken to assess a possible relationship between the tumor location and the incidence of World Health Organization (WHO) Grades II and III meningiomas...
  63. ncbi Endoscopic management of skull base defects associated with persistent pneumocephalus following previous open repair: a preliminary report
    David W Clark
    Department of Otorhinolaryngology Head and Neck Surgery, Texas Sinus Institute, Texas Skull Base Institute, University of Texas at Houston Medical School, Houston, TX 77030, USA
    Otolaryngol Head Neck Surg 142:820-6. 2010
    To describe the management of anterior skull base defects in patients who present with pneumocephalus after previous open neurosurgical intervention.
  64. ncbi Prevention and management of skull base injury
    Esther Kim
    Division of Rhinology, Department of Otolaryngology, Vanderbilt University Medical Center, 7209 Medical Center East South Tower, 1215 21st Avenue South, Nashville, TN 37232 8605, USA
    Otolaryngol Clin North Am 43:809-16. 2010
    b>Skull base defects and injuries are rare, but may occur during endoscopic sinus surgery, as a result of facial trauma, or as a result of tumors in the anterior cranial fossa...
  65. ncbi Intracranial infection as a common complication following war missile skull base injury
    B Splavski
    Division of Neurosurgery, Osijek University Hospital, Osijek, Croatia
    Injury 31:233-7. 2000
    ..therapy, and early surgery in the management of intracranial infection following war missile penetrating skull base injury. There were 21 skull base missile injuries treated surgically in a 4-year period...
  66. ncbi Clinical utility of the inferior turbinate flaps in the reconstruction of the nasal septum and skull base
    Dong Hoon Lee
    Department of Otolaryngology Head and Neck Surgery, Chonnam National University Medical School and Hwasun Hospital, Hwasun, South Korea
    J Craniofac Surg 23:e322-6. 2012
    ..been used for the repair of the septal perforation, and the PPITF has been used for the reconstruction of the skull base. Because of the technical difficulties of endoscopic preparation of the ITF, clinical studies on endoscopic ..
  67. ncbi Intraoperative facial motor evoked potential monitoring with transcranial electrical stimulation during skull base surgery
    Charles C J Dong
    Division of Neurosurgery, Department of Surgery, University of British Columbia, Vancouver, BC, Canada
    Clin Neurophysiol 116:588-96. 2005
    ....
  68. ncbi Anterior and middle cranial fossa skull base reconstruction using microvascular free tissue techniques: surgical complications and functional outcomes
    Ernest S Chiu
    Tulane Health Sciences Center, New Orleans, LA, USA
    Ann Plast Surg 60:514-20. 2008
    Surgical ablation for oncologic disease requiring skull base resection can result in both facial disfigurement and a complex wound defect with exposed orbital content, oral cavity, bone, and dural lining...
  69. ncbi Inflammatory pseudotumour involving the skull base and cervical spine
    Y S Cho
    Department of Otorhinolaryngology-Head and Neck Surgery, Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul, Korea
    J Laryngol Otol 115:580-4. 2001
    ..IPT involving the skull base and cervical spine is distinctly rare and usually indistinguishable from aggressive neoplasms or infection...
  70. ncbi Endoscopic endonasal anatomy and approaches to the anterior skull base: a neurosurgeon's viewpoint
    Bashar Abuzayed
    Department of Neurosurgery, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey
    J Craniofac Surg 21:529-37. 2010
    The objective of this study was to review the endoscopic anatomy of the anterior skull base, defining the pitfalls of endoscopic endonasal approaches to this region...
  71. ncbi Prevention and management of vascular injuries in endoscopic surgery of the sinonasal tract and skull base
    C Arturo Solares
    Department of Otolaryngology, Medical College of Georgia, Augusta, GA 30907, USA
    Otolaryngol Clin North Am 43:817-25. 2010
    ..These techniques have been further expanded to manage skull base pathologies. This expansion has been facilitated by a better understanding of the endonasal skull base anatomy...
  72. ncbi A revolution in skull base surgery: the quality of life matters!
    James I Ausman
    Surg Neurol 65:635-6. 2006
  73. ncbi Endoscopic endonasal surgery of the midline skull base: anatomical study and clinical considerations
    Luigi M Cavallo
    Division of Neurosurgery, Department of Neurological Sciences, Universita degli Studi di Napoli Federico II, Naples, Italy
    Neurosurg Focus 19:E2. 2005
    The midline skull base is an anatomical area that extends from the anterior limit of the cranial fossa down to the anterior border of the foramen magnum...
  74. ncbi Real-time computed tomography image update for endoscopic skull base surgery
    B A Woodworth
    Department of Otorhinolaryngology Head and Neck Surgery, University of Pennsylvania Health System, Philadelphia, Pennsylvania 19104, USA
    J Laryngol Otol 122:361-5. 2008
    ..However, conventional computer-aided systems do not provide intra-operative updated computed tomography imaging. We describe the technical aspects of the xCAT, a new intra-operative mobile volume computed tomography scanner...
  75. ncbi History of endoscopic skull base surgery: its evolution and current reality
    Daniel M Prevedello
    Department of Neurological Surgery, University of Virginia Health Sciences Center, Charlottesville, Virginia, USA
    J Neurosurg 107:206-13. 2007
    ..between otorhinolaryngologists and neurosurgeons has produced a new subspecialty of "endoscopic skull base surgery...
  76. ncbi Inferior turbinate pedicle flap for endoscopic skull base defect repair
    Richard J Harvey
    Department of Otolaryngology Skull Base Surgery, St Vincent s Hospital, Darlinghurst, Sydney, NSW 2010, Australia
    Am J Rhinol Allergy 23:522-6. 2009
    Endoscopic skull base reconstruction (ESBR) is an important advance in the management of skull base defects...
  77. ncbi One thousand endoscopic skull base surgical procedures demystifying the infection potential: incidence and description of postoperative meningitis and brain abscesses
    Yuriko Kono
    Division of Infectious Diseases, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Infect Control Hosp Epidemiol 32:77-83. 2011
    Endonasal endoscopic skull base surgery (ESBS) is perceived as having a high risk of infection because it is performed through the sinuses, which are not sterile.
  78. ncbi Enabling an unimpeded surgical approach to the skull base in patients with cranial hyperostosis, exemplarily demonstrated for craniometaphyseal dysplasia
    Philipp Juergens
    Department of Cranio Maxillofacial Surgery, University Hospital Basel, University of Basel, Switzerland
    J Neurosurg 115:528-35. 2011
    ..Skull bone more than 50 mm thick in some regions was reduced to physiological thickness. The patient was thus in a stage that neurosurgical interventions could be performed with a regular risk within a reasonable time of treatment...
  79. ncbi Prevertebral corridor: posterior pathway for reconstruction of the ventral skull base
    Abdullah Durmaz
    Department of Otorhinolaryngology and Head and Neck Surgery, Gulhane Military Medical School, Ankara, Turkey
    J Craniofac Surg 22:848-53. 2011
    ..flaps, such as the pericranial and temporoparietal fascia flaps, are currently used for reconstruction of skull base defects after endoscopic endonasal surgery whenever local vascularized flaps, such as the nasoseptal flap, are ..
  80. ncbi Mucocele rate after endoscopic skull base reconstruction using vascularized pedicled flaps
    Benjamin S Bleier
    Department of Otology and Laryngology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts 02114, USA
    Am J Rhinol Allergy 25:186-7. 2011
    Postoperative cerebrospinal fluid leak is a significant risk after endoscopic skull base surgery. Recently, novel reconstructive techniques using vascularized pedicled mucosal flaps have been applied to decrease this potential risk...
  81. ncbi Mucocele after transnasal endoscopic repair of traumatic anterior skull base fistula in children
    Benjamin Verillaud
    Department of Pediatric Otolaryngology, Head and Neck Surgery, Hopital d Enfants Armand Trousseau, APHP and University Paris VI, 26 Avenue Arnold Netter, 75571 Paris Cedex 12, France
    Int J Pediatr Otorhinolaryngol 75:1137-42. 2011
    To report the long-term sinonasal complications after endoscopic repair of anterior skull base fractures in children. This study describes mucocele formation in 6 patients treated endoscopically for posttraumatic CSF fistulae...
  82. ncbi Skull base trauma: diagnosis and management
    Madjid Samii
    Department of Neurosurgery, Hannover College of Medicine, Carl Neuberg Strasse 1, D 30625 Hannover, Germany
    Neurol Res 24:147-56. 2002
    ..Extensive dural laceration and severe neurovascular damage may accompany skull base injuries...
  83. ncbi Orthopedic cervical headgear with an expanded inner bow in class II correction
    M Kirjavainen
    Department of Pedodontics and Orthodontics, University of Helsinki, Finland
    Angle Orthod 70:317-25. 2000
    ..The cephalometric analysis suggested that the observed improvement of the occlusion was due to an inhibition of forward growth of the maxilla and anterior downward rotation of the palate...
  84. ncbi Endoscopic endonasal versus open transcranial resection of anterior midline skull base meningiomas
    Ricardo J Komotar
    Department of Neurological Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    World Neurosurg 77:713-24. 2012
    To assess the advantages and limitations of the endoscopic endonasal approach to anterior skull base meningiomas, a minimally invasive approach that avoids extensive bone drilling, brain retraction, and manipulation of nerves and critical ..
  85. ncbi Anteriorly based inferior turbinate flap for endoscopic skull base reconstruction
    Ziv Gil
    The Head and Neck Surgery Unit, Department of Otolaryngology Head and Neck Surgery, Tel Aviv Sourasky Medical Center, Sackler School of Medicine, Tel Aviv University, Israel Tel Aviv, Israel
    Otolaryngol Head Neck Surg 146:842-7. 2012
    In the absence of the nasal septal flap, there is limited ability to reconstruct the anterior skull base because of the paucity of alternative intranasal vascularized flaps...
  86. ncbi Endoscopic endonasal surgery (EES) in skull base repairs and CSF leakage
    C Bachert
    ENT-Department Head and Neck Surgery, University Hospital Ghent, Belgium
    Acta Otorhinolaryngol Belg 54:179-89. 2000
    This report aims to summarise the current role of Endoscopic Endonasal Surgery (EES) for skull base and cerebrospinal fluid (CSF) leakage repair, to provide some guidelines for the clinical diagnosis and technical procedures of repair, to ..
  87. ncbi Efficacy of the pedicled nasoseptal flap without cerebrospinal fluid (CSF) diversion for repair of skull base defects: incidence of postoperative CSF leaks
    Jean Anderson Eloy
    Department of Otolaryngology Head and Neck Surgery, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, NJ 07103, USA
    Int Forum Allergy Rhinol 2:397-401. 2012
    The advances in endoscopic skull base surgery have led to the resection of increasingly larger cranial base lesions and the creation of larger skull base defects with the potential for increased postoperative high-flow cerebrospinal fluid ..
  88. ncbi Endoscopic endonasal repair of anterior skull base non-traumatic cerebrospinal fluid leaks, meningoceles, and encephaloceles
    Gurston G Nyquist
    Department of Otorhinolaryngology, Weill Cornell Medical College, New York Presbyterian Hospital, New York, New York 10065, USA
    J Neurosurg 113:961-6. 2010
    ..endonasal approach has become the preferred technique for CSF leak and encephalocele repair of the anterior skull base. The purpose of this study is to identify patient characteristics; review adjunctive perioperative treatments, ..
  89. ncbi Endoscopic management of anterior skull base encephaloceles
    Mark E Boseley
    Department of Otolaryngology Head and Neck Surgery, University of Cincinnati Medical Center, Cincinnati, Ohio, USA
    Ann Otol Rhinol Laryngol 113:30-3. 2004
    Encephaloceles are relatively rare phenomena produced by the protrusion of brain and dura through an anterior skull base defect. Although they can occur as congenital defects, encephaloceles can also present after trauma...
  90. ncbi 10 pearls for safe endoscopic skull base surgery
    Madeleine R Schaberg
    Department of Otolaryngology, Weill Medical College of Cornell University, New York Presbyterian Hospital, 1305 York Avenue, Fifth Floor, New York, NY 10065, USA
    Otolaryngol Clin North Am 43:945-54. 2010
    The introduction of the endoscopic endonasal approach for the management of lesions of the skull base has produced a paradigm shift in the way complicated lesions of this complex anatomic location are managed...
  91. ncbi Latissimus dorsi free flap reconstruction of anterior skull base defects
    Angelique Girod
    Head and Neck Oncologic Surgery Unit, Institut Curie, 26 Rue d Ulm, 75005 Paris, France
    J Craniomaxillofac Surg 40:177-9. 2012
    Surgery of extensive skull base tumour results of a defect of soft and hard tissue and dura. Free flap reconstruction provides tissue to restore the defect and separate the intracranial content from the bacterial flora of the nasal fossae...
  92. ncbi Transoral robotic surgery of the skull base: a cadaver and feasibility study
    John Y K Lee
    Department of Neurosurgery, University of Pennsylvania, Philadelphia, PA 19104, USA
    ORL J Otorhinolaryngol Relat Spec 72:181-7. 2010
    The goal of this study was to determine the potential role as well as the current limitations of the da Vinci Surgical System robot in transoral surgery of the skull base.
  93. ncbi Parapharyngeal neuroglial heterotopia extending through the skull base in a neonate with airway obstruction
    Thierry A G M Huisman
    Department of Diagnostic Imaging, University Hospital Zurich, CH 8032 Zurich, Switzerland
    J Pediatr Surg 42:1764-7. 2007
    ..Preoperative identification of intracranial extension is essential for planning surgery to prevent postoperative cerebrospinal fluid leaks or possible meningitis...
  94. ncbi Nasopharyngeal carcinoma with skull base invasion and hydrocephalus: a case report
    Chih Jen Wang
    Department of Neurosurgery, Kaohsiung Medical University, Kaohsiung, Taiwan
    Kaohsiung J Med Sci 18:582-4. 2002
    We describe a case of nasopharyngeal carcinoma (NPC) with diffuse skull base bony destruction, resulting in obstructive hydrocephalus...
  95. ncbi Navigated surgery at the lateral skull base and registration and preoperative imagery: experimental results
    Florian Kral
    Department of Otorhinolaryngology, Innsbruck Medical University, Anichstr 35, 6020 Innsbruck, Austria
    Arch Otolaryngol Head Neck Surg 137:144-50. 2011
    To assess factors that affect the accuracy of navigated surgery at the human lateral skull base, including the choice of registration procedures and preoperative computed tomography (CT) section thickness, and to compare target ..
  96. ncbi Localization and infliction pattern of iatrogenic skull base defects following endoscopic sinus surgery at a teaching hospital
    Klaus Bumm
    Department of Otorhinolaryngology, Head and Neck Surgery, Friedrich Alexander University Erlangen Nuremberg, Waldstrasse 1, D 91054 Erlangen, Germany
    Auris Nasus Larynx 36:671-6. 2009
    ..We present our results of over 14 years of experience from endoscopic repair of CSF rhinorrhea with long-term follow-up...
  97. pmc An integrated system for planning, navigation and robotic assistance for skull base surgery
    Tian Xia
    Department of Computer Science, Johns Hopkins University, Baltimore, MD 21218, USA
    Int J Med Robot 4:321-30. 2008
    We developed an image-guided robot system to provide mechanical assistance for skull base drilling, which is performed to gain access for some neurosurgical interventions, such as tumour resection...
  98. ncbi Fully endoscopic expanded endonasal approach treating skull base lesions in pediatric patients
    Amin Kassam
    Minimally Invasive endoNeurosurgery Center, University of Pittsburgh School of Medicine, Pennsylvania, USA
    J Neurosurg 106:75-86. 2007
    ..endoscopic approaches to determine their safety and efficacy in the treatment of pediatric patients who harbor skull base lesions...
  99. ncbi Skull base abnormalities in osteogenesis imperfecta: a cephalometric evaluation of 54 patients and 108 control volunteers
    Outi Kovero
    Department of Oral Radiology, Institute of Dentistry, University of Helsinki, Finland
    J Neurosurg 105:361-70. 2006
    ..The head is often abnormally shaped, and changes in skull base anatomy in the form of basilar impression and basilar invagination have been reported...
  100. ncbi Skull base osteomyelitis: the effect of comorbid disease on hospitalization
    Vanessa S Rothholtz
    Department of Otolaryngology Head and Neck Surgery, University of California Irvine, Orange, California 92868, USA
    Laryngoscope 118:1917-24. 2008
    b>Skull base osteomyelitis is a rare disease that has a high morbidity and mortality rate if diagnosis and treatment are delayed. Our objective was to perform a more detailed analysis of skull base osteomyelitis in the inpatient population...
  101. ncbi Phenotypic manifestations and management of hyperostosis cranialis interna, a hereditary bone dysplasia affecting the calvaria and the skull base
    J J Waterval
    Department of Otorhinolaryngology Head and Neck Surgery, Maastricht University Medical Center, Maastricht, The Netherlands
    Am J Med Genet A 152:547-55. 2010
    ..bone disorder that is characterized by endosteal hyperostosis and osteosclerosis of the calvaria and the skull base (OMIM 144755)...

Research Grants28

  1. Pediatric Percutaneous Cochlear Implantation Clinical Validation &Implementation
    Robert F Labadie; Fiscal Year: 2012
    ..PCI reduces CI surgery to a single pass of a drill from the lateral skull base to the cochlea...
  2. mTOR signaling and sporadic chordomas
    Sangyeul Han; Fiscal Year: 2010
    ..This project is aimed to examine genetic mutation in chordomas and to generate chordoma animal models, and thus has significance in public health. ..
  3. Third International Chordoma Research Workshop: Catalyzing New Advances in Chordo
    EDWARD LES; Fiscal Year: 2011
    ..The outcome of this workshop will translate to improved treatments for patients with this deadly bone cancer. ..
  4. PROTON RADIATION THERAPY RESEARCH
    Thomas F DeLaney; Fiscal Year: 2013
    ..patients with non-small cell lung cancer, liver tumors, pediatric medulloblastoma and rhabdomyosarcoma, spine/skull base sarcomas, and paranasal sinus malignancies...
  5. Computer Modeled Multiportal Approaches to the Skull Base
    Kris Moe; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Lesions of the anterior and middle skull base are diverse in their etiology and cause significant morbidity due to close proximity to the carotid arteries, brain, orbits, optic nerves and chiasm...
  6. GENETIC REGULATORY NETWORK IN CRANIOFACIAL DEVELOPMENT
    Wei Hsu; Fiscal Year: 2013
    ..of viscerocranium and neurocranium, which is subdivided into the calvarium/skull vault and chondrocranium/skull base. During development of the calvarium, cranial sutures serve as growth centers for skeletogenesis...
  7. Robotic Natural Orifice Skull Base Surgery
    ROBERT JAMES WEBSTER; Fiscal Year: 2013
    ..objective of this proposal is to reduce the invasiveness and increase the safety of surgical procedures at the skull base by introducing a new robotic system for natural orifice skull base surgery...
  8. High-Performance Cone-Beam CT Guidance of Head and Neck Surgery
    Jeffrey H Siewerdsen; Fiscal Year: 2010
    ..in challenging interventional tasks, including ethmoid sinus ablation, trans-sphenoid approach to the CNS, and skull base lesion excision;and 3...
  9. Targeting Deep Brain Tumors with MRI-Insertable Magnetic Gradients and Nanopartic
    IRVING WEINBERG; Fiscal Year: 2013
    ....
  10. Dynamic Vocal Fold Abduction for Bilateral Paralysis
    Michael Broniatowski; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  11. WEARABLE ARTIFICIAL LABYRINTH IN MOTION SICKNESS/VERTIGO
    WESLEY KRUEGER; Fiscal Year: 2005
    ..and in the rehabilitative process in patients with dizziness following vestibular nerve section or removal of a skull base lesion such as acoustic tumor...
  12. Precision Freehand Sculpting for Skull Base
    Constantinos Nikou; Fiscal Year: 2009
    b>Skull base surgery is technically the most demanding of all of the neurosurgical procedures because of the intertwining of the hard, thick skull and delicate neural and vascular structures...
  13. An Integrated CT-based Image-Guided Neurosurgical System
    Senhu Li; Fiscal Year: 2013
    ..The product will use advanced imaging methods to produce low-artifact soft tissue images, even in the skull base and posterior fossa, which are typically challenging regions for x-ray imagers...
  14. GENE THERAPY FOR LARYNGEAL PARALYSIS
    Paul Flint; Fiscal Year: 2004
    ..paralysis usually occurs as a result of the surgical removal of tumor involving the head and neck region and skull base. Thyroid surgery, carotid endarterectomy, cardiothoracic and primary lung procedures may also result in ..
  15. An Integrated CT-based Image-Guided Neurosurgical System
    JOSEPH STAYMAN; Fiscal Year: 2005
    ..In many difficult procedures that involve vital structures, like the resection of tumors at the skull base, image-guidance can be a necessity...
  16. Modeling meningioma growth orthotopically in the nude mouse
    Anita Lal; Fiscal Year: 2007
    ..techniques of local drug delivery specifically to meningiomas which grow on the surface of the brain or the skull base, and for investigations into the unique tumor-host interactions of meningiomas...
  17. Therapeutic Studies of Primary CNS Malignancies-NABTT
    Gene Barnett; Fiscal Year: 2008
    ..abstract_text> ..
  18. Nanostenting Hydrogels for Sinus Surgery
    RICHARD ORLANDI; Fiscal Year: 2004
    ..The results of these Phase I studies will determine the feasibility and the optimal chemical properties of a nanostenting HA gel for human trials. ..
  19. Cognitive Studies of Temporal Lobe Function in Man
    Guila Glosser; Fiscal Year: 2003
    ..b) To assess the usefulness of presurgical fMRI activation measures during an allocentric spatial memory task for predicting memory performance following ATL. ..
  20. THE ROLE OF BHLH GENES IN GLIOGENESIS AND GLIOMA BIOLOGY
    Robert Rostomily; Fiscal Year: 2004
    ..abstract_text> ..
  21. Gene therapy for treatment of craniofacial dysplasia
    Stephanos Kyrkanides; Fiscal Year: 2004
    ..Completion of this study will aid in the development of novel therapies for the management of genetic disorders. ..
  22. Mineral and Mechanical Properties of Bone
    Sarandeep Huja; Fiscal Year: 2005
    ..Future interventional studies will examine the mechanisms for the initial and the long-term adaptive response in material properties of bone. ..
  23. Does peripheral localized chronic inflammation predispose to neurodegeneration?
    Stephanos Kyrkanides; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  24. Trigeminal Neuralgia Association 5th National Conference
    Albert Rhoton; Fiscal Year: 2005
    ..abstract_text> ..
  25. Optical imaging of epilepsy in rat and human neocortex
    THEODORE SCHWARTZ; Fiscal Year: 2007
    ..These experiments will set the groundwork for implementing optical recordings in general clinical practice as a novel technique for mapping and predicting human seizures. ..
  26. Joint degeneration: Somatic mosaic analysis in a transgenic mouse
    Stephanos Kyrkanides; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  27. NEURONAL FUNCTION IN CRANIOFACIAL DEVELOPMENT
    Stephanos Kyrkanides; Fiscal Year: 2004
    ..abstract_text> ..
  28. Recombinant FIV vectors for the delivery of siRNA therapy to joints
    Stephanos Kyrkanides; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..