human mammary glands

Summary

Summary: Glandular tissue in the BREAST of human that is under the influence of hormones such as ESTROGENS; PROGESTINS; and PROLACTIN. In WOMEN, after PARTURITION, the mammary glands secrete milk (MILK, HUMAN) for the nourishment of the young.

Top Publications

  1. ncbi Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures
    Jayanta Debnath
    Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
    Methods 30:256-68. 2003
  2. ncbi Information networks in the mammary gland
    Lothar Hennighausen
    Laboratory of Genetics and Physiology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Rev Mol Cell Biol 6:715-25. 2005
  3. pmc Modeling dynamic reciprocity: engineering three-dimensional culture models of breast architecture, function, and neoplastic transformation
    Celeste M Nelson
    Life Sciences Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, MS 977 225A, Berkeley, CA 94720, USA
    Semin Cancer Biol 15:342-52. 2005
  4. ncbi Post-lactational mammary gland regression: molecular basis and implications for breast cancer
    Christine J Watson
    Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QP, UK
    Expert Rev Mol Med 8:1-15. 2006
  5. pmc Role of Notch signaling in cell-fate determination of human mammary stem/progenitor cells
    Gabriela Dontu
    Comprehensive Cancer Center, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA
    Breast Cancer Res 6:R605-15. 2004
  6. pmc Homology with vesicle fusion mediator syntaxin-1a predicts determinants of epimorphin/syntaxin-2 function in mammary epithelial morphogenesis
    Connie S Chen
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    J Biol Chem 284:6877-84. 2009
  7. ncbi Deciphering the mammary epithelial cell hierarchy
    John Stingl
    Department of Pathology, University of Cambridge, Cambridge, UK
    Cell Cycle 5:1519-22. 2006
  8. pmc BRCA1 regulates human mammary stem/progenitor cell fate
    Suling Liu
    Comprehensive Cancer Center, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    Proc Natl Acad Sci U S A 105:1680-5. 2008
  9. ncbi Progesterone receptors in mammary gland development and tumorigenesis
    Orla M Conneely
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Mammary Gland Biol Neoplasia 8:205-14. 2003
  10. pmc Keeping abreast of the mammary epithelial hierarchy and breast tumorigenesis
    Jane E Visvader
    VBCRC Victorian Breast Cancer Research Consortium Laboratory, The Walter and Eliza Hall of Medical Research, Parkville, Victoria 3052, Australia
    Genes Dev 23:2563-77. 2009

Research Grants

Detail Information

Publications271 found, 100 shown here

  1. ncbi Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures
    Jayanta Debnath
    Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
    Methods 30:256-68. 2003
    ....
  2. ncbi Information networks in the mammary gland
    Lothar Hennighausen
    Laboratory of Genetics and Physiology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Rev Mol Cell Biol 6:715-25. 2005
    ..Steroids and simple peptide hormones initiate and carry out complex developmental programmes, and reverse genetics has been used to define the underlying mechanistic connections...
  3. pmc Modeling dynamic reciprocity: engineering three-dimensional culture models of breast architecture, function, and neoplastic transformation
    Celeste M Nelson
    Life Sciences Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, MS 977 225A, Berkeley, CA 94720, USA
    Semin Cancer Biol 15:342-52. 2005
    ..We propose the need for engineered tissues that faithfully recapitulate their native structures to allow a greater understanding of tissue function, dysfunction, and potential therapeutic intervention...
  4. ncbi Post-lactational mammary gland regression: molecular basis and implications for breast cancer
    Christine J Watson
    Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QP, UK
    Expert Rev Mol Med 8:1-15. 2006
    ..In this review, I discuss the roles of the JAK-STAT, NF-kappaB and other signalling pathways in the regulation of apoptosis and tissue remodelling during involution...
  5. pmc Role of Notch signaling in cell-fate determination of human mammary stem/progenitor cells
    Gabriela Dontu
    Comprehensive Cancer Center, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA
    Breast Cancer Res 6:R605-15. 2004
    ..The vertebrate Notch1 and Notch4 homologs are involved in normal development of the mammary gland, and mutated forms of these genes are associated with development of mouse mammary tumors...
  6. pmc Homology with vesicle fusion mediator syntaxin-1a predicts determinants of epimorphin/syntaxin-2 function in mammary epithelial morphogenesis
    Connie S Chen
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    J Biol Chem 284:6877-84. 2009
    ..These results provide a dramatic demonstration of the use of structural information about one molecule to define a functional motif of a second molecule that is related at the sequence level but highly divergent functionally...
  7. ncbi Deciphering the mammary epithelial cell hierarchy
    John Stingl
    Department of Pathology, University of Cambridge, Cambridge, UK
    Cell Cycle 5:1519-22. 2006
    ..Suggestive parallels between mouse and human mammary cells point to the likelihood that a similarly structured multi-step differentiation program characterizes the mammary gland from both species...
  8. pmc BRCA1 regulates human mammary stem/progenitor cell fate
    Suling Liu
    Comprehensive Cancer Center, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    Proc Natl Acad Sci U S A 105:1680-5. 2008
    ..Because BRCA1 also plays a role in DNA repair, our work suggests that loss of BRCA1 may result in the accumulation of genetically unstable breast stem cells, providing prime targets for further carcinogenic events...
  9. ncbi Progesterone receptors in mammary gland development and tumorigenesis
    Orla M Conneely
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Mammary Gland Biol Neoplasia 8:205-14. 2003
    ....
  10. pmc Keeping abreast of the mammary epithelial hierarchy and breast tumorigenesis
    Jane E Visvader
    VBCRC Victorian Breast Cancer Research Consortium Laboratory, The Walter and Eliza Hall of Medical Research, Parkville, Victoria 3052, Australia
    Genes Dev 23:2563-77. 2009
    ..Potential relationships between normal epithelial populations and breast tumor subtypes are discussed, with implications for understanding the cellular etiology underpinning breast tumor heterogeneity...
  11. pmc Hedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cells
    Suling Liu
    Comprehensive Cancer Center, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109 0946, USA
    Cancer Res 66:6063-71. 2006
    ..These studies support a cancer stem cell model in which the hedgehog pathway and Bmi-1 play important roles in regulating self-renewal of normal and tumorigenic human mammary stem cells...
  12. ncbi Cell adhesion in mammary gland biology and neoplasia
    Charles H Streuli
    School of Biological Sciences, University of Manchester, Manchester, United Kingdom
    J Mammary Gland Biol Neoplasia 8:375-81. 2003
  13. pmc Evidence for a stem cell hierarchy in the adult human breast
    Rene Villadsen
    Department of Cellular and Molecular Medicine, Faculty of Health Sciences, and Zoophysiological Laboratory, University of Copenhagen, and Department of Pathology, State University Hospital, Copenhagen, Denmark
    J Cell Biol 177:87-101. 2007
    ..These findings identify an adult human breast ductal stem cell activity and its earliest descendants...
  14. pmc A high-throughput migration assay reveals HER2-mediated cell migration arising from increased directional persistence
    Neil Kumar
    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    Biophys J 91:L32-4. 2006
    ..Observed consistent increases in persistence associated with HER2 overexpression indicate a prospective mechanism for invasiveness previously documented in HER2-overexpressing human breast tumors...
  15. ncbi Protein tyrosine kinase Syk modulates EGFR signalling in human mammary epithelial cells
    Anja Ruschel
    Department of Molecular Biology, Max Planck Institute of Biochemistry, Am Klopferspitz 18, D 82152 Martinsried, Germany
    Cell Signal 16:1249-61. 2004
    ..Our findings demonstrate that Syk acts a negative control element of EGFR signalling...
  16. doi A method for quantifying normal human mammary epithelial stem cells with in vivo regenerative ability
    Peter Eirew
    Terry Fox Laboratory, British Columbia Cancer Agency, 675 West Tenth Avenue, Vancouver, British Columbia, Canada
    Nat Med 14:1384-9. 2008
    ..This new assay procedure sets the stage for investigations of mechanisms regulating normal human mammary stem cells (and possibly stem cells in other tissues) and their relationship to human cancer stem cell populations...
  17. ncbi Molecular definition of breast tumor heterogeneity
    Michail Shipitsin
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Cancer Cell 11:259-73. 2007
    ..Our data suggest prognostic relevance of CD44+ cells and therapeutic targeting of distinct tumor cell populations...
  18. ncbi The role of C/EBPbeta in mammary gland development and breast cancer
    Sandra L Grimm
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Mammary Gland Biol Neoplasia 8:191-204. 2003
    ..Thus, C/EBPbeta appears to play a role in the specification of progenitor cell fate not only in the mammary gland, but also in a number of other tissues...
  19. ncbi Multiple regions of Crumbs3 are required for tight junction formation in MCF10A cells
    Vanessa C Fogg
    Department of Internal Medicine, University of Michigan Medical School, 210 Washtenaw Avenue, Ann Arbor, MI 48109 2216, USA
    J Cell Sci 118:2859-69. 2005
    ..Our results suggest that Crumbs3 plays an important role in epithelial tight junction formation, and also provide the first known functional role for the mammalian Crumbs FERM binding domain...
  20. ncbi The mammary gland "side population": a putative stem/progenitor cell marker?
    Matthew J Smalley
    The Breakthrough Breast Cancer Centre, The Institute of Cancer Research, London, United Kingdom
    J Mammary Gland Biol Neoplasia 10:37-47. 2005
    ..However, evidence that the SP is enriched for stem cells is, at the moment, only correlative, and there are potentially confounding technical issues. We still await formal proof that the SP contains a stem cell population...
  21. pmc Three-dimensional culture models of normal and malignant breast epithelial cells
    Genee Y Lee
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    Nat Methods 4:359-65. 2007
    ..Alternatively, the 3D 'on-top' assay, in which cells are cultured on top of a thin lrECM gel overlaid with a dilute solution of lrECM, may be used as described in Box 2 (Fig. 1 and Fig. 2)...
  22. pmc Bim regulation of lumen formation in cultured mammary epithelial acini is targeted by oncogenes
    Mauricio J Reginato
    Harvard Medical School, Department of Cell Biology, 240 Longwood Ave, Boston, MA 02115, USA
    Mol Cell Biol 25:4591-601. 2005
    ..Thus, Bim is a critical regulator of luminal apoptosis during mammary acinar morphogenesis in vitro and may be an important target of oncogenes that disrupt glandular epithelial architecture...
  23. ncbi DNA methylation control of tissue polarity and cellular differentiation in the mammary epithelium
    Cedric Plachot
    Department of Basic Medical Sciences, Purdue University, West Lafayette, IN 47907 2026, USA
    Exp Cell Res 298:122-32. 2004
    ..These results suggest that DNA methylation is a mechanism by which mammary epithelial differentiation is coordinated both at the tissue and cellular levels...
  24. pmc ROCK-generated contractility regulates breast epithelial cell differentiation in response to the physical properties of a three-dimensional collagen matrix
    Michele A Wozniak
    Department of Pharmacology, University of Wisconsin, Madison, WI 53706, USA
    J Cell Biol 163:583-95. 2003
    ....
  25. ncbi Escaping from Flatland: clinical and biological aspects of human mammary duct anatomy in three dimensions
    James J Going
    Department of Pathology, University of Glasgow, Glasgor Royal Infirmary, 84 Castle Street, Glasgow G4 0SF, Scotland, UK
    J Pathol 203:538-44. 2004
    ..While population A ducts appear accessible to duct endoscopy or lavage, population B and population C ducts may be less accessible...
  26. ncbi Mammary stem cells and breast cancer--role of Notch signalling
    Gillian Farnie
    Breast Biology Group, Division of Cancer Studies, Faculty of Medicine and Human Sciences, University of Manchester, Paterson Institute for Cancer Research, Wilmslow Road, Manchester, M20 4BX, UK
    Stem Cell Rev 3:169-75. 2007
    ....
  27. ncbi EGF-receptor-mediated mammary epithelial cell migration is driven by sustained ERK signaling from autocrine stimulation
    Elizabeth J Joslin
    Department of Biological Engineering, MIT, Cambridge, MA 02139, USA
    J Cell Sci 120:3688-99. 2007
    ..Thus, in our mammary epithelial cell system, migration and proliferation are differentially sensitive to the mode of EGF ligand presentation...
  28. ncbi Identification of the mammary line in mouse by Wnt10b expression
    Jacqueline M Veltmaat
    UMR 144 CNRS Institut Curie, Equipe de Morphogenèse Cellulaire et Progression Tumorale, Paris, France
    Dev Dyn 229:349-56. 2004
    ..To date, the formation of the mammary line expressing Wnt10b is the earliest discernible ectodermal event in murine embryonic mammary gland development...
  29. ncbi The ultrastructure of MCF-10A acini
    Jean M Underwood
    Department of Cell Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Cell Physiol 208:141-8. 2006
    ..Electron microscopy has the resolution required to survey features of MCF-10A cell and acinus architecture that may change with manipulations designed to induce malignant phenotypes...
  30. ncbi Lumen formation during mammary epithelial morphogenesis: insights from in vitro and in vivo models
    Arnaud A Mailleux
    Department of Cell Biology, Harvard Medical School, Boston, Massachussets 02115, USA
    Cell Cycle 7:57-62. 2008
    ..Herein we put into perspective the relevance of our in vitro and in vivo findings to discuss luminal space formation and maintenance during mammary morphogenesis...
  31. ncbi Diagnostic value of ductoscopy in the diagnosis of nipple discharge and intraductal proliferations in comparison to standard methods
    Susanne Grunwald
    Department of Obstetrics and Gynecology, Ernst Moritz Arndt University, Greifswald, Germany
    Onkologie 30:243-8. 2007
    ..Ductoscopy is gaining increased importance in the diagnosis of nipple discharge of unclear origin and intraductal proliferation. For this reason we compared its diagnostic value and feasibility to standard diagnostic methods...
  32. pmc HER4 intracellular domain (4ICD) activity in the developing mammary gland and breast cancer
    Frank E Jones
    Department of Pathology, University of Colorado Health Sciences Center, 12800 East 19th Avenue, Aurora, CO 80045, USA
    J Mammary Gland Biol Neoplasia 13:247-58. 2008
    ..In addition a developmental and temporal model of 4ICD action in the normal breast and during the progression of breast cancer will be presented to explain the paradox of divergent HER4 and 4ICD activities...
  33. ncbi Somatic inactivation of E-cadherin and p53 in mice leads to metastatic lobular mammary carcinoma through induction of anoikis resistance and angiogenesis
    Patrick W B Derksen
    Division of Molecular Biology, Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands
    Cancer Cell 10:437-49. 2006
    ..Moreover, loss of E-cadherin induced anoikis resistance and facilitated angiogenesis, thus promoting metastatic disease. Our results suggest that loss of E-cadherin contributes to both mammary tumor initiation and metastasis...
  34. ncbi Transcriptional signatures of environmentally relevant exposures in normal human mammary epithelial cells: benzo[a]pyrene
    Channa Keshava
    Heatlh Effects Laboratory Division, National Institute for Occupational Safety and Health CDC, Centers for Disease Control and Prevention, DHHS, 1095 Willowdale Road, M S L 3014, Morgantown, WV 26505 2888, USA
    Cancer Lett 221:201-11. 2005
    ..These studies provide a complementary approach to molecular epidemiology for the investigation of differential susceptibility to chemical carcinogens, and specifically polycyclic aromatic hydrocarbons...
  35. pmc A developmentally regulated inducer of EMT, LBX1, contributes to breast cancer progression
    Min Yu
    Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Genes Dev 23:1737-42. 2009
    ..Thus, aberrant expression of LBX1 may lead to the activation of a developmentally regulated EMT pathway in human breast cancer...
  36. ncbi Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules
    Yi Zhang
    Biological Engineering Division, Massachusetts Institute of Technnology, Cambridge, Massachusetts 02139, USA
    Mol Cell Proteomics 4:1240-50. 2005
    ..Additional analysis and modeling of the data generated in this study are likely to yield more sophisticated models of receptor tyrosine kinase-initiated signal transduction, trafficking, and regulation...
  37. pmc Isolation and characterization of functional mammary gland stem cells
    Bryan Welm
    Department of Anatomy, University of California, San Francisco, San Francisco, CA, USA
    Cell Prolif 36:17-32. 2003
    ..These data suggest that the heterogeneity of mouse models of breast cancer may partially reflect the selection or expansion of different progenitors...
  38. doi Induction of EMT by twist proteins as a collateral effect of tumor-promoting inactivation of premature senescence
    Stéphane Ansieau
    INSERM, U590, Lyon F 69008, France
    Cancer Cell 14:79-89. 2008
    ..These findings suggest an unanticipated direct link between early escape from failsafe programs and the acquisition of invasive features by cancer cells...
  39. pmc New highlights on stroma-epithelial interactions in breast cancer
    Mary Helen Barcellos-Hoff
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA
    Breast Cancer Res 7:33-6. 2005
    ..In the present article, we discuss three recent publications that highlight the complex role the stroma has during the development of cancer and the potential for targeting the stroma by therapeutic approaches...
  40. ncbi Mammary ductoscopy for the evaluation of nipple discharge and comparison with standard diagnostic techniques
    Susanne Grunwald
    Department of Gynecology and Obstetrics, Ernst Moritz Arndt University, Greifswald, and Clinic of Minimally Invasive Surgery, Evangelic Hospital Hubertus, Berlin, Germany
    J Minim Invasive Gynecol 13:418-23. 2006
    ..To describe performance of breast duct endoscopy and compare the method with conventional diagnostic techniques...
  41. ncbi CCAAT/Enhancer binding protein delta (c/EBPdelta) regulation and expression in human mammary epithelial cells: II. Analysis of activating signal transduction pathways, transcriptional, post-transcriptional, and post-translational control
    G S Sivko
    Department of Veterinary Biosciences and Division of Molecular Biology and Cancer Genetics, Ohio State Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA
    J Cell Biochem 93:844-56. 2004
    ..These results indicate that the human C/EBPdelta gene is controlled at multiple levels, consistent with a role for C/EBPdelta in cell cycle control and/or cell fate determination...
  42. ncbi Cancer stem cells--an old idea that's new again: implications for the diagnosis and treatment of breast cancer
    Lynda Li Song
    Loyola University Chicago, Breast Cancer Research Program, Cardinal Bernardin Cancer Center, 2160 S First Avenue, Bldg 112, Room 236, Maywood, IL 60153, USA
    Expert Opin Biol Ther 7:431-8. 2007
    ..The authors present a brief overview of this theory, its potential implications and the evidence supporting it, focusing specifically on breast cancer...
  43. pmc Nipple aspiration and ductal lavage in women with a germline BRCA1 or BRCA2 mutation
    Gillian Mitchell
    Division of Haematology and Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Australia
    Breast Cancer Res 7:R1122-31. 2005
    ..The aim of this study was to collect serial samples of nipple aspirate (NA) and ductal lavage (DL) fluid from women with germline BRCA1/2 mutations in order to create a biorepository for use in identifying biomarkers of breast cancer risk...
  44. ncbi CCAAT/Enhancer binding protein delta (c/EBPdelta) regulation and expression in human mammary epithelial cells: I. "Loss of function" alterations in the c/EBPdelta growth inhibitory pathway in breast cancer cell lines
    G S Sivko
    Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio 43210, USA
    J Cell Biochem 93:830-43. 2004
    ....
  45. ncbi Dehydroepiandrosterone, androgens and the mammary gland
    Fernand Labrie
    Laboratory of Molecular Endocrinology and Oncology, Laval University Hospital Research Center CRCHUL and Laval University, Quebec City, Quebec, Canada
    Gynecol Endocrinol 22:118-30. 2006
    ....
  46. ncbi Introduction: the role of myoepithelial cells in integration of form and function in the mammary gland
    Sunil Lakhani
    Molecular and Cellular Pathology, Mayne Medical School, Queensland Institute of Medical Research and The Royal Brisbane and Women s Hospital, University of Queensland, Brisbane, QLD, Australia
    J Mammary Gland Biol Neoplasia 10:197-8. 2005
  47. ncbi Quantitative multiplex methylation-specific PCR analysis doubles detection of tumor cells in breast ductal fluid
    Mary Jo Fackler
    Department of Oncology, Johns Hopkins University School of Medicine, Baltimore Maryland, USA
    Clin Cancer Res 12:3306-10. 2006
    ..We hypothesized that quantitative analysis of methylated genes will provide enhanced detection of cancer cells present in cytologic specimens...
  48. ncbi Ductoscopy and intraductal vacuum assisted biopsy in women with pathologic nipple discharge
    Michael Hunerbein
    Department of Surgery and Surgical Oncology, Charite Universitatsmedizin Berlin, Campus Berlin Buch and Helios Hospital, Buch, Berlin, Germany
    Breast Cancer Res Treat 99:301-7. 2006
    ..A major limitation of this technique is the inability to obtain tissue samples from suspicious intraductal lesions. We present a novel technique for ductoscopic biopsy of intraluminal tumors...
  49. ncbi Ductal lavage of fluid-yielding and non-fluid-yielding ducts in BRCA1 and BRCA2 mutation carriers and other women at high inherited breast cancer risk
    Allison W Kurian
    Division of Oncology, Department of Medicine, Stanford University School of Medicine, 875 Blake Wilbur Drive, Stanford, CA 94305 5820
    Cancer Epidemiol Biomarkers Prev 14:1082-9. 2005
    ..Most publications on ductal lavage for cell collection report cannulating fluid-yielding ducts only. We report lavage of fluid-yielding and non-fluid-yielding ducts in women at high inherited breast cancer risk...
  50. ncbi Transcriptional control of the cell cycle in mammary gland development and tumorigenesis
    Ricardo D Coletta
    Department of Obstetrics and Gynecology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Mammary Gland Biol Neoplasia 9:39-53. 2004
    ....
  51. ncbi The mammary gland and its origin during synapsid evolution
    Olav T Oftedal
    Department of Conservation Biology, Conservation and Research Center, Smithsonian National Zoological Park, Washington, District of Columbia 20008, USA
    J Mammary Gland Biol Neoplasia 7:225-52. 2002
    ..Nipples that arose from the mammary patch rendered mammary hairs obsolete, while placental structures have allowed lactation to be truncated in living eutherians...
  52. ncbi Breast magnetic resonance image screening and ductal lavage in women at high genetic risk for breast carcinoma
    Anne Renee Hartman
    Department of Medicine, Stanford University School of Medicine, Stanford, California 94305 5458, USA
    Cancer 100:479-89. 2004
    ....
  53. ncbi Adenoma of anogenital mammary-like glands
    Sartaj Ahmed
    Department of Medicine, Rhode Island Hospital and Brown Medical School, Providence, Rhode Island 02903, USA
    J Am Acad Dermatol 57:896-8. 2007
    ..The possibility of adenomas of anogenital mammary-like glands should be considered when evaluating patients with a mass in this area with confirmation by tissue biopsy or aspiration cytology...
  54. pmc c-Myc transforms human mammary epithelial cells through repression of the Wnt inhibitors DKK1 and SFRP1
    Victoria H Cowling
    Dartmouth Medical School, Norris Cotton Cancer Center, One Medical Center Drive, Lebanon, NH 03756, USA
    Mol Cell Biol 27:5135-46. 2007
    ..DKK1 and SFRP1 inhibit the transformed phenotype of breast cancer cell lines, and DKK1 inhibits tumor formation. We propose a positive feedback loop for activation of the c-myc and Wnt pathways in breast cancer...
  55. pmc Re-evaluation of mammary stem cell biology based on in vivo transplantation
    Gilbert H Smith
    Mammary Stem Cell Biology Section, Mammary Biology and Tumorigenesis Laboratory, CCR, NCI, 37 Convent Drive, Bldg 37, Rm 1106, National Institutes of Health, Bethesda, MD 20892 USA
    Breast Cancer Res 10:203. 2008
    ..In the present article, these issues are reviewed and discussed to provide a greater understanding of the complexity of these multiplex interactions...
  56. ncbi Caspase-independent cytochrome c release is a sensitive measure of low-level apoptosis in cell culture models
    Joshua C Goldstein
    Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Aging Cell 4:217-22. 2005
    ..Further, apoptosis increased subtly but measurably when human mammary epithelial and skin fibroblast cells entered crisis, indicating that cell death during crisis is largely non-apoptotic...
  57. doi Microdochectomy for single-duct pathologic nipple discharge and normal or benign imaging and cytology
    Sophocles Lanitis
    Breast Care Unit, Mary Stanford Wing, 5th Floor, St Mary s Hospital NHS Trust, Praed Street, London W2 1NY, UK
    Breast 17:309-13. 2008
    ..Pre-operative workup and imaging may not be suspicious in patients with single-duct PND and underlying malignancy, therefore, microdochectomy should be considered in such cases...
  58. ncbi Function of PEA3 Ets transcription factors in mammary gland development and oncogenesis
    Natasza A Kurpios
    Department of Biochemistry, McMaster University, Hamilton, Ontario, Canada
    J Mammary Gland Biol Neoplasia 8:177-90. 2003
    ..Taken together these observations suggest that the PEA3 subfamily proteins play key regulatory roles in both mammary gland development and oncogenesis...
  59. ncbi Stem cells in mammary development and carcinogenesis: implications for prevention and treatment
    Gabriela Dontu
    Department of Internal Medicine, Hematology Oncology, Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA
    Stem Cell Rev 1:207-13. 2005
    ..Furthermore, the concept of cancer as a disease of stem and progenitor cells has profound implications for the development of new strategies for cancer prevention and therapy...
  60. ncbi On mammary stem cells
    Wendy A Woodward
    Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030 3498, USA
    J Cell Sci 118:3585-94. 2005
    ....
  61. pmc The receptor tyrosine kinase EphA2 promotes mammary adenocarcinoma tumorigenesis and metastatic progression in mice by amplifying ErbB2 signaling
    Dana M Brantley-Sieders
    Department of Medicine, Division of Rheumatology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    J Clin Invest 118:64-78. 2008
    ..Moreover, EphA2 function in tumor progression appeared to depend on oncogene context, an important consideration for the application of therapies targeting EphA2...
  62. ncbi Human mammary epithelial cell transformation through the activation of phosphatidylinositol 3-kinase
    Jean J Zhao
    Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Cancer Cell 3:483-95. 2003
    ..However, elevated c-myc expression cannot replace H-rasV12 for tumorigenesis. These observations begin to define the pathways perturbed during the transformation of HMECs...
  63. ncbi Generation and analysis of Brca1 conditional knockout mice
    Chu Xia Deng
    Genetics of Development and Disease Branch, Digetive and Kidney Diseases, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Methods Mol Biol 280:185-200. 2004
    ..Finally, we performed functional analysis of mammary tumorigenesis in Brca1 conditional knockout mice. The methods to generate and analyze these Brca1 conditional knockout mice are described in this chapter...
  64. ncbi Apoptosis regulation in the mammary gland
    K A Green
    School of Biological Sciences, University of Manchester, Stopford Building, Oxford Road, M13 9PT, Manchester, United Kingdom
    Cell Mol Life Sci 61:1867-83. 2004
    ..This review explores what is currently known about the triggers for apoptosis in the normal mammary gland, and how they link with the intrinsic apoptotic machinery...
  65. ncbi Epithelial progenitors in the normal human mammary gland
    John Stingl
    Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, British Columbia, Canada
    J Mammary Gland Biol Neoplasia 10:49-59. 2005
    ....
  66. ncbi DCIS, cytokeratins, and the theory of the sick lobe
    Tibor Tot
    Department of Pathology, Central Hospital, 791 82, Falun, Sweden
    Virchows Arch 447:1-8. 2005
    ....
  67. pmc Multiple mechanisms are responsible for transactivation of the epidermal growth factor receptor in mammary epithelial cells
    Karin D Rodland
    Systems Biology Program, Pacific Northwest National Laboratory, Richland, Washington 99354, USA
    J Biol Chem 283:31477-87. 2008
    ....
  68. ncbi Reconstruction of human mammary tissues in a mouse model
    David A Proia
    Department of Anatomy and Cellular Biology, Tufts University School of Medicine, 136 Harrison Ave, Boston, Massachusetts 02111, USA
    Nat Protoc 1:206-14. 2006
    ..As a whole, this model system has the potential to improve the understanding of crosstalk between tissue stroma and the epithelium as well as factors involved in breast stem cell biology tumor initiation and progression...
  69. pmc Autocrine CSF-1R activation promotes Src-dependent disruption of mammary epithelial architecture
    Carolyn N Wrobel
    Dept of Cell Biology, Harvard Medical School, 240 Longwood Ave, Boston, MA 02115, USA
    J Cell Biol 165:263-73. 2004
    ..These findings provide a mechanistic basis whereby CSF-1R could contribute to invasive progression in epithelial cancers...
  70. pmc Key stages in mammary gland development: the cues that regulate ductal branching morphogenesis
    Mark D Sternlicht
    Department of Anatomy, University of California, San Francisco, CA 94143 0452, USA
    Breast Cancer Res 8:201. 2006
    ..Thus a clearer understanding of the underlying endocrine and paracrine pathways that regulate mammary branching may shed light on how they contribute to cancer and how their ill effects might be overcome or entirely avoided...
  71. ncbi NF-kappaB in mammary gland development and breast cancer
    Yixue Cao
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California, San Diego, La Jolla, California 92093, USA
    J Mammary Gland Biol Neoplasia 8:215-23. 2003
    ..Elevated NF-kappaB DNA-binding activity is detected in both mammary carcinoma cell lines and primary human breast cancer tissues...
  72. ncbi Beta-catenin and Tcfs in mammary development and cancer
    Sarah Hatsell
    Department of Cell Biology, New York University School of Medicine, New York, New York 10016, USA
    J Mammary Gland Biol Neoplasia 8:145-58. 2003
    ..Cyclin D1, however, is dispensable for tumor formation and the initiation of alveologenesis but is essential for later alveolar expansion...
  73. ncbi Serotonin regulates mammary gland development via an autocrine-paracrine loop
    Manabu Matsuda
    Department of Molecular and Cellular Physiology, University of Cincinnati, Cincinnati, OH 45221, USA
    Dev Cell 6:193-203. 2004
    ..Thus, autocrine-paracrine serotonin signaling is an important regulator of mammary homeostasis and early involution...
  74. pmc The alveolar switch: coordinating the proliferative cues and cell fate decisions that drive the formation of lobuloalveoli from ductal epithelium
    Samantha R Oakes
    Garvan Institute of Medical Research, St Vincent s Hospital, Darlinghurst, NSW 2010, Australia
    Breast Cancer Res 8:207. 2006
    ..Here we review the current understanding of the components of the alveolar switch and conclude with an examination of the role of the ets transcription factor Elf5. We propose that Elf5 is a key regulator of the alveolar switch...
  75. ncbi Transforming growth factor (TGF)-beta in conjunction with H-ras activation promotes malignant progression of MCF10A breast epithelial cells
    Eun Sook Kim
    College of Pharmacy, Duksung Women s University, Seoul 132 714, Republic of Korea
    Cytokine 29:84-91. 2005
    ....
  76. pmc Factors necessary to produce basoapical polarity in human glandular epithelium formed in conventional and high-throughput three-dimensional culture: example of the breast epithelium
    Cedric Plachot
    Department of Basic Medical Sciences and Purdue Center for Cancer Research, Purdue University, West Lafayette, IN 47907, USA
    BMC Biol 7:77. 2009
    ..Although factors important for the establishment of basal polarity have been identified, requirements for the formation of apical polarity in three-dimensional tissue structures have not been thoroughly investigated...
  77. ncbi Three-dimensional cell culture to model epithelia in the female reproductive system
    Hibret A Adissu
    Department of Basic Medical Sciences, Purdue University, West Lafayette, IN 47907 2026, USA
    Reprod Sci 14:11-9. 2007
    ....
  78. pmc The role of major duct excision and microdochectomy in the detection of breast carcinoma
    Mary F Dillon
    Department of Surgery, St Vincent s University Hospital, Elm Park, Dublin 4, Ireland
    BMC Cancer 6:164. 2006
    ..The aim of this study was to determine whether pre-operative factors can identify those patients that are most at risk of carcinoma...
  79. ncbi Comparative analysis of minimally invasive microductectomy versus major duct excision in patients with pathologic nipple discharge
    Ranjna Sharma
    Department of General Surgery, Cleveland Clinic Foundation, Ohio 44195, USA
    Surgery 138:591-6; discussion 596-7. 2005
    ..The purpose of this study was to compare the diagnostic yield of 2 groups of patients who underwent either minimally invasive microductectomy or major duct excision for pathologic nipple discharge...
  80. ncbi Human breast duct anatomy, the 'sick lobe' hypothesis and intraductal approaches to breast cancer
    James J Going
    Division of Cancer Sciences and Molecular Pathology, University of Glasgow, Glasgow, Scotland, UK
    Breast Cancer Res Treat 97:285-91. 2006
    ....
  81. pmc Endothelial cell migration and vascular endothelial growth factor expression are the result of loss of breast tissue polarity
    Amy Chen
    Department of Surgery, University of California at San Francisco, 94143, USA
    Cancer Res 69:6721-9. 2009
    ..These data confirm the importance of tissue architecture and polarity in malignant progression...
  82. ncbi Ductal lavage findings in women with known breast cancer undergoing mastectomy
    Seema A Khan
    Department of Surgery, Feinberg School of Medicine, Northwestern University, Chicago IL, USA
    J Natl Cancer Inst 96:1510-7. 2004
    ..To assess the utility of ductal lavage as a cancer diagnostic test, we investigated the association between ductal lavage cytologic findings and histologic findings in women with known breast cancer undergoing mastectomy...
  83. ncbi Epithelial-stromal interactions in the mouse and human mammary gland in vivo
    Hema Parmar
    University of California, 3rd and Parnassus, Department of Anatomy, HSW 1323, San Francisco, CA 94143, USA
    Endocr Relat Cancer 11:437-58. 2004
    This review deals with the development and hormonal responses of mouse and human mammary glands. A major focus of the review is the role of mesenchymal-epithelial interactions in embryonic mammary development and the role of stromal-..
  84. ncbi Comprehensive analysis of oncogenic effects of PIK3CA mutations in human mammary epithelial cells
    Haijun Zhang
    Breast Cancer Program, Karmanos Cancer Institute, Detroit, MI 48201, USA
    Breast Cancer Res Treat 112:217-27. 2008
    ....
  85. ncbi Detection of LOH and mitochondrial DNA alterations in ductal lavage and nipple aspirate fluids from hngh-risk patients
    Claudine Isaacs
    Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20007, USA
    Breast Cancer Res Treat 84:99-105. 2004
    ..One NAF sample from a BRCA1 patient showed a mtDNA mutation. Our data demonstrates the feasibility of performing molecular studies using the free DNA present in the ductal fluid, while the intact cells can be used for cytologic studies...
  86. ncbi TGFbeta as a potential mediator of progesterone action in the mammary gland of pregnancy
    Jenifer Monks
    Department of Physiology and Biophysics, MS 8309, University of Colorado Health Sciences, Anschutz Medical Campus, P O Box 6511, 12800 E 19th Avenue, Aurora, CO 80045, USA
    J Mammary Gland Biol Neoplasia 12:249-57. 2007
    ..Yet no formal link between the two has ever been established. This work aims to review the evidence for and against a link between progesterone and TGFbeta, raise unanswered questions, and to propose further lines of research...
  87. ncbi Pathologic nipple discharge: surgery is imperative in postmenopausal women
    Steffi Lau
    Department of Obstetrics and Gynecology, University of Rostock, Universitatsfrauenklinik, Suedring 81, 18059 Rostock, Germany
    Ann Surg Oncol 12:546-51. 2005
    ....
  88. ncbi What signals operate in the mammary niche?
    Tamara Tanos
    NCCR Molecular Oncology, Ecole Polytechnique Federale de Lausanne EPFL, ISREC Swiss Institute for Experimental Cancer Research, 155, Chemin des Boveresses, CH 1066 Epalinges, Switzerland
    Breast Dis 29:69-82. 2008
    ..Some of the downstream mediators are in common with other niches such as Wnt and possibly Notch signaling. Other signals are specific to the mammary gland such as amphiregulin and RANKL...
  89. ncbi The Nuclear Factor I (NFI) gene family in mammary gland development and function
    Janice Murtagh
    Conway Institute of Biomolecular and Biomedical Research and Department of Pharmacology, University College Dublin, Belfield, Dublin 4, Ireland
    J Mammary Gland Biol Neoplasia 8:241-54. 2003
    ..We discuss current data showing that unique NFI proteins are expressed during lactation and involution and suggest that the NFI gene family likely has multiple important functions throughout mammary gland development...
  90. ncbi A review of mammary ductoscopy in breast cancer
    Daigo Yamamoto
    Department of Surgery, Kansai Medical University, Moriguchi, Osaka, Japan
    Breast J 10:295-7. 2004
    ..The additional molecular biologic study or ductal lavage may enhance the ability to direct and limit subsequent surgery when removing the offending lesions...
  91. ncbi Helix-loop-helix proteins in mammary gland development and breast cancer
    Pierre Yves Desprez
    California Pacific Medical Center, Cancer Research Institute, San Francisco, California 94115, USA
    J Mammary Gland Biol Neoplasia 8:225-39. 2003
    ..The purpose of this review is to summarize the evidence implicating HLH proteins in the regulation of normal and transformed mammary epithelial cell phenotypes...
  92. pmc Inhibition of CCN6 (WISP3) expression promotes neoplastic progression and enhances the effects of insulin-like growth factor-1 on breast epithelial cells
    Yanhong Zhang
    Department of Pathology, University of Michigan Medical Center, 1150 W Medical Center Drive, Ann Arbor, MI 48109, USA
    Breast Cancer Res 7:R1080-9. 2005
    ..We hypothesized that inhibition of CCN6 might result in the loss of a growth regulatory function that protects mammary epithelial cells from the tumorigenic effects of growth factors, particularly IGF-1...
  93. ncbi Breast cancer-associated PIK3CA mutations are oncogenic in mammary epithelial cells
    Steven J Isakoff
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer Res 65:10992-1000. 2005
    ..Together, these data support the notion that the cancer-associated mutations in PIK3CA may significantly contribute to breast cancer pathogenesis and represent attractive targets for therapeutic inhibition...
  94. pmc Cooperative interactions of HER-2 and HPV-16 oncoproteins in the malignant transformation of human mammary epithelial cells
    Kathleen M Woods Ignatoski
    Department of Radiation Oncology and the Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI, USA
    Neoplasia 7:788-98. 2005
    ..These results indicate that HER-2, E6, and E7 cooperate with endogenous EGFR to yield fully transformed cells...
  95. ncbi Human breast epithelial stem cells and their regulation
    Helen Kalirai
    Breast Biology Group, Division of Cancer Studies, University of Manchester, Christie Hospital, Wilmslow Road, Manchester, M20 4BX, UK
    J Pathol 208:7-16. 2006
    ..By understanding the molecular pathways that regulate self-renewal of normal mammary stem cells, it may be possible to target the activation of these pathways in breast tumours...
  96. ncbi siRNA gelsolin knockdown induces epithelial-mesenchymal transition with a cadherin switch in human mammary epithelial cells
    Hiroki Tanaka
    Division of Cancer Gene Regulation, Research Section of Disease Control, Institute for Genetic Medicine, Hokkaido University, Sapporo 060 0815, Japan
    Int J Cancer 118:1680-91. 2006
    ....
  97. ncbi The clinical applications of mammary ductoscopy
    Pedro F Escobar
    The Cleveland Clinic Foundation, Cleveland, OH, USA
    Am J Surg 191:211-5. 2006
    ..The procedure can be performed under local anesthesia in the office setting. This article reviews the rationale, current clinical applications, and limitations of MD...
  98. ncbi Characterization of integrin and anchorage dependence in mammary epithelial cells following c-erbB2-induced epithelial-mesenchymal transition
    Lachmi E Jenndahl
    Department of Medical Biochemistry, University of Goteborg, Sweden
    Tumour Biol 27:50-8. 2006
    ..This notion was supported by the finding that integrin blocking of the fibroblastic cells in fibrin was without effect on proliferation...
  99. ncbi Expression of endothelins and their receptors promotes an invasive phenotype of breast tumor cells but is insufficient to induce invasion in benign cells
    Thorsten Hagemann
    Department of Haematology and Oncology, University of Gottingen, Gottingen, Germany
    DNA Cell Biol 24:766-76. 2005
    ....
  100. pmc HER-2 overexpression differentially alters transforming growth factor-beta responses in luminal versus mesenchymal human breast cancer cells
    Cindy A Wilson
    Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Breast Cancer Res 7:R1058-79. 2005
    ....
  101. ncbi The potential role of breast ductoscopy in breast cancer screening
    W Al Sarakbi
    Department of Breast Surgery, St George s Hospital, London, United Kingdom
    Int J Fertil Womens Med 50:208-11. 2005
    ..This article focuses on the potential of this technique in breast cancer screening and highlights its limitations in this context...

Research Grants73

  1. Biology and Pathologies of Type V Collagen
    Daniel S Greenspan; Fiscal Year: 2013
    ..If such studies are borne out, the ramifications are huge, with profound implications for understanding, evaluating and treating atherosclerotic disease - the number one killer of adult human beings in the western hemisphere. ..
  2. Role of JAK2-PAK1 interaction in prolactin-dependent signaling
    Maria Diakonova; Fiscal Year: 2013
    ..Understanding how these proteins work together will help to design new therapeutic approaches and possibly drugs for treatment of different human diseases and breast cancer. ..
  3. Bioassay for Breast Cancer Prevention
    JoEllen Welsh; Fiscal Year: 2010
    ....
  4. Plant-Derived Estrogens and Cell Proliferation
    Emma Shtivelman; Fiscal Year: 2011
    ..Our goal is to discover estrogens that do not promote cancer, but retain the beneficial of estrogens on body weight and fat accumulation. ..
  5. Metabolic Adapation and Control of Lactation in Humans
    Morey W Haymond; Fiscal Year: 2010
    ....
  6. Epigenetic effects of developmental endocrine disruptor exposure in the ovary
    Mehmet Uzumcu; Fiscal Year: 2010
    ..A mechanistic understanding of the epigenetic effects of EDC exposure can lead to better prevention, diagnosis, and therapies, thereby improving public health and reducing health care costs. ..
  7. MECHANISMS OF MILK LIPID SECRETION
    JAMES LEWIS MCMANAMAN; Fiscal Year: 2013
    ....
  8. NEURAL AND ENDOCRINE CONSEQUENCES OF PARITY
    ROBERT STAFFORD BRIDGES; Fiscal Year: 2012
    ..Overall, reproductive experience-induced shifts in endocrine activities may affect endocrine-related diseases and behaviors later in adulthood, i.e. breast cancer, autoimmune diseases, and postpartum mood disorders. ..
  9. Exploratory Studies on the Anti-Breast Cancer Function of Bamboo Extract
    Jun Panee; Fiscal Year: 2010
    ..Knowledge obtained from these studies will guide the application of this abundant and sustainable natural resource in chemoprevention of breast cancer, the most prevalent cancer among women in the United States. ..
  10. Transgenerational effects of maternal high fat diet during pregnancy on breast ca
    Leena A Hilakivi-Clarke; Fiscal Year: 2013
    ....
  11. Role of Stat3 in Breast Cancer Tumorigenesis
    Jacqueline F Bromberg; Fiscal Year: 2010
    ....
  12. Evolution of the Immune Response to Cytomegalovirus Transmitted via Breast Milk
    Lynn Puddington; Fiscal Year: 2010
    ....
  13. Site-directed Chemotherapy for Breast Cancer using Novel Angiogenesis Inhibitor
    Shaker A Mousa; Fiscal Year: 2010
    ..A novel technology, the use of nanoparticles to encapsulate the test drugs, and direct them to tumors will be tested to determine whether these nanoparticles can improve the delivery of drugs and minimize the associated toxicities. ..
  14. Role of Heat Shock Transcription Factor Hsf1 in Tumorigenesis
    Nahid F Mivechi; Fiscal Year: 2013
    ..We will use a conditional gene knockout technology to examine the effects of hsf1 deficiency in the Her2/Neu-induced breast cancer model for tumors of epithelial origin. ..
  15. ECM compliance and cell cycle control
    RICHARD ASSOIAN; Fiscal Year: 2012
    ....
  16. Effect of bisphenol A exposure on mammary stem cell function and transformation
    Luzhe Sun; Fiscal Year: 2013
    ....
  17. ANALYSIS OF CHROMATIN REMODELING IN MAMMARY GLAND DEVELOPMENT USING TILING ARRAYS
    Monique Rijnkels; Fiscal Year: 2009
    ..These studies will provide a foundation for understanding the mechanisms that determine differentiation and organogenesis of specific tissues. ..
  18. The Role of Long Non-coding RNAs in EMT and Cancer Stem Cells
    Jason I Herschkowitz; Fiscal Year: 2013
    ....
  19. Study on the intracellular Network of TBX3
    Taosheng Huang; Fiscal Year: 2010
    ..Elucidation of the TBX3- HDAC interaction will deepen our understanding of the functions of TBX3 and may also lead to the identification of a novel therapeutic target for breast cancer. ..
  20. FUNCTION OF THE RAS RELATED RAL PROTEINS
    LARRY FEIG; Fiscal Year: 2009
    ..It will also test whether knockdown of other components of the Ral signaling cascade in fibroblasts also blocks tumor progression, and whether these effects can be recapitulated in mice...
  21. Treatment of breast cancer tumor growth and metastasis with an anti-MMP-9 DNAzyme
    MIRANDA A HALLETT; Fiscal Year: 2011
    ..Thus, in this proposal we are taking an innovative approach to the treatment of breast carcinomas by studying the effect of the AM9D therapy on tumor growth and metastasis, the major mechanism of morbidity and mortality. ..
  22. Regulation of Organized Intestinal Lymphoid Tissues by TRANCE/RANKL
    Ifor R Williams; Fiscal Year: 2012
    ..These studies are expected to contribute to existing knowledge of how specific imbalances in the intestinal immune system can lead to various forms of human inflammatory bowel disease. ..
  23. Mammary Gland Morphogenesis and Breast Cancer
    Ian G Macara; Fiscal Year: 2013
    ..We have developed methods that facilitate the rapid analysis of gene function in mammary gland development and cancer. We will use these methods to identify new cancer genes, and to understand how breast cancers develop and metastasize. ..
  24. Energy Restrction and Mammary Cancer
    Henry J Thompson; Fiscal Year: 2013
    ....
  25. QTL and QTL Genes Underlying Lactation Performance
    Darryl L Hadsell; Fiscal Year: 2010
    ..The experiments described in this proposal will use powerful new mouse genetic tools to identify and map the genes which could regulate lactation outcomes in breastfeeding women. ..
  26. BRCA1 and progesterone receptors in breast cancer
    Eva Y Lee; Fiscal Year: 2013
    ..How the progesterone receptor activity is regulated will be studied. The results will provide insights into breast cancer intervention and will have important implications for in breast cancer prevention and treatment. ..
  27. ERR-gamma-dependent mammary tumorigenesis in response to BPA and a high-fat diet
    Rebecca B Riggins; Fiscal Year: 2010
    ....
  28. Defining the role of the tumor-initiating cell niche in breast cancer
    Mei Zhang; Fiscal Year: 2011
    ..Insights into niche-TIC interactions may provide new therapeutic targets for drug development with the goal of both preventing breast cancer and reducing metastasis. ..
  29. Targeting the Obesity-Inflammation-COX-Aromatase Axis to Lower Breast Cancer Risk
    ANDREW JESS DANNENBERG; Fiscal Year: 2013
    ..Collectively, the results of the proposed studies will offer new insights into strategies to reduce the risk of HR-positive breast cancer. ..
  30. Oligosaccharide moieties of human milk glycans that inhibit pathogens
    David S Newburg; Fiscal Year: 2013
    ..The availability of synthetic human milk glycans suitable for oral consumption that inhibit HIV or rotavirus could have large impact on these important threats to public health. ..
  31. The Effect of PTHrP During Lactation
    John J Wysolmerski; Fiscal Year: 2010
    ..The final aim will use genetic models to define the effects of milk PTHrP on neonatal bone and mineral metabolism. ..
  32. Growth and Carcinogenic Potential in the Postnatal Mammary Gland
    Demetri D Spyropoulos; Fiscal Year: 2010
    ..The practical application of this work is toward the development of high throughput identification of bioactive compounds that promote or prevent breast carcinogenesis. ..
  33. Quinone Oxidoreductases and Mammary Toxicity/Carcinogenenicity
    ANIL KUMAR JAISWAL; Fiscal Year: 2013
    ..Studies are significant since human individuals carry deleterious mutations in NQO1 and NQO2 and are deficient in these proteins. ..
  34. ELECTROPHYSIOLOGICAL CORRELATES OF VASOPRESSIN RELEASE
    William E Armstrong; Fiscal Year: 2011
    ..Furthermore, phasic, bursting activity is exhibited in many neurons and endocrine cells, so the mechanisms we uncover may aide in the general understanding of patterned activity. ..
  35. Regulation of Cellular Zn Redistribution: A Role of ZnT2
    Shannon L Kelleher; Fiscal Year: 2012
    ..Thus, this application has significance for improving public health outcomes and advancing our understanding of basic cellular mechanisms. ..
  36. Regulation of mammary gland biology by RLIM/Rnf12 and the paternal X chromosome
    INGOLF M BACH; Fiscal Year: 2013
    ..Moreover, the results of our research will show that mammary gland biology is decisively controlled by sex-specific epigenetic mechanisms with profound implications for development, differentiation, evolution and disease. ..
  37. Proeolytic Processing of Cyclin E in Breast Cancer
    Khandan Keyomarsi; Fiscal Year: 2013
    ..As such, a targeted and personalized therapy can be justified for those patients who currently do not have such treatment strategies available to them. ..
  38. Nuclear cofactors in hormone signaling
    Hongwu Chen; Fiscal Year: 2012
    ..Understanding the process will provide novel insights to the underlying molecular mechanisms of steroid receptor function in female reproduction and breast cancers as well as other endocrine disorders. ..
  39. Cadherin-catenin Mediated Contact Inhibition of Cell Growth
    Barry M Gumbiner; Fiscal Year: 2013
    ..Findings from these studies should reveal how contact inhibition regulates normal tissue development and how the loss of contact inhibition leads to the formation and progression of tumors. ..
  40. FUNCTION OF THE CALCIUM SENSING RECEPTOR IN THE BREAST
    John J Wysolmerski; Fiscal Year: 2013
    ..Aim 3 will examine if stimulation of PTHrP production by the CaR contributes to the development of osteolytic bone metastases in vivo. ..
  41. Nuclear Architecture, NcRNAs and Epigenetics in Transcriptional Regulation by ER
    Chunru Lin; Fiscal Year: 2012
    ....
  42. In Utero Exposure to Bisphenol A: Effects on the Fetal Epigenome
    DANA DOLINOY; Fiscal Year: 2013
    ....
  43. Cross-Talk Between Estrogen and T Cells Mediated Pathways in Lupus Pathogenesis
    Alessandra B Pernis; Fiscal Year: 2010
    ..Specifically, we will: 1. Assess the mechanisms by which IBP controls the expression of ERa in T cells. 2. Investigate the role of estrogen on the lupus-like syndrome that develops in the absence of IBP. ..
  44. Smoothened function as a G-Protein Coupled Receptor in mammary epithelial cells
    Hugo Villanueva; Fiscal Year: 2013
    ..All of these events create the perfect environment in which to not only present research to my peers and faculty, but to receive valuable feedback which will only advance my research to a higher level. ..
  45. Regulation of Pancreatic Tumor Progression by Disabled-2
    Barbara A Hocevar; Fiscal Year: 2010
    ..The studies proposed here will provide prelimary evidence to support a role of Disabled-2 in prevention of pancreatic tumor progression and metastasis which may lead to improved diagnosis and treatment of pancreatic cancer. ..
  46. The role of tristetraprolin in control of breast cancer progression
    Jianguo Liu; Fiscal Year: 2013
    ....
  47. Chronic Cadmium Exposure Promotes Breast Cancer Progression
    Maggie C Louie; Fiscal Year: 2012
    ....
  48. Radiation and Genomic Instability in Finite Lifespan Human Mammary Epithelium
    Amy Kronenberg; Fiscal Year: 2010
    ....
  49. The role of FOXC1 in basal-like breast cancer
    Xiaojiang Cui; Fiscal Year: 2013
    ..Our study will help establish a critical molecular marker for detection and diagnosis of basal-like cancers, and also help uncover the biological basis for the cellular traits and phenotypes of basal-like breast cancer. ..
  50. INTEGRIN FUNCTION AND SIGNALING IN CARCINOMA PROGRESSION
    Arthur M Mercurio; Fiscal Year: 2012
    ..The involvement of SOX9 in basal-like tumors and its relationship to the beta4 signature will also be assessed. ..
  51. STEROID ANTAGONISTS AND RESISTANCE IN BREAST CANCER
    Dean P Edwards; Fiscal Year: 2012
    ..The research in this application will provide insights into the mechanisms and role of PR activation of signaling pathways with the long-term goal of developing pathway selective agents as potential therapeutics. ..
  52. FUNCTIONAL DEVELOPMENT OF THE MAMMARY GLAND
    Steven M Anderson; Fiscal Year: 2013
    ..This concerted effort will provide mechanistic underpinnings for understanding lactation failure in women related to diabetes and/or obesity. ..
  53. A Narrowed Window for Targeting Metabolic Flexibility in Breast Cancer Prevention
    Pepper J Schedin; Fiscal Year: 2013
    ....
  54. Defining the role of the tumor-initiating cell niche in breast cancer
    Mei Zhang; Fiscal Year: 2013
    ..Thus, I believe this will provide me an outstanding training environment that will facilitate my transition to become an independent scientist. ..
  55. Extrinsic Regulation of Epidermal Homeostatasis
    Valerie Horsley; Fiscal Year: 2013
    ..Patients with alopecia, hair shaft disorders, or chronic wounds could potentially benefit from this research. ..
  56. Breast Adipose Participates to Bioactivate Vitamin D and Inhibit Breast Cancer
    Glendon M Zinser; Fiscal Year: 2010
    ..The proposed studies are of an important and under- investigated area of mammary gland biology that may serve as a nutritional preventative and/or therapeutic option to fight breast cancer. ..
  57. Vitamin D, Metabolic Flux and Breast Cancer
    JoEllen Welsh; Fiscal Year: 2013
    ..Although our dietary studies will be conducted in mice, the conserved relationship between dietary vitamin D and serum 25D will provide a starting point for extrapolation to human populations. ..
  58. The role of WNT10B and HMGA2 in Lung Metastasis in Triple Negative Breast Cancer
    GUSTAVO ADOLFO MIRANDA-CARBONI; Fiscal Year: 2013
    ..Our findings may alter therapeutics for the metastatic TNBC tumors. ..
  59. Design & Synthesis of Novel CNS-Active Oxytocin and Vasopressin Receptor Ligands
    Edward Roberts; Fiscal Year: 2010
    ....
  60. Deguelin in therapy of triple negative breast cancer
    Rajendra G Mehta; Fiscal Year: 2013
    ....
  61. Tumor-Suppressive Function of SLC5A8 in Mammary Gland and its Relevance to Breast
    Muthusamy Thangaraju; Fiscal Year: 2012
    ..This mode of therapy may be effective not only for the estrogen receptor-positive breast cancer but also for the estrogen receptor-negative breast cancer. ..
  62. Role of PALB2 in the DNA damage response and breast cancer suppression
    Bing Xia; Fiscal Year: 2013
    ..g. double strand breaks, interstrand crosslinks, etc. Finally, in the longer term the mouse models generated and characterized here may prove useful for pre-clinical testing of cancer drugs. ..
  63. Omega-3 fat to reduce risk for breast cancer
    WANDA ELAINE HARDMAN; Fiscal Year: 2010
    ....
  64. AKT 1 AND MAMMARY CELL SURVIVAL DURING THE ESTRUS CYCLE
    Robert Strange; Fiscal Year: 2004
    ....
  65. VITAMIN A TRANSPORT DURING LACTATION
    A Ross; Fiscal Year: 1992
    ..Information to be developed in each of these specific aims will provide insight into the mechanisms by which retinol is metabolized and transported across the breast during lactation...
  66. ROLE OF STROMA IN MAMMARY GLAND CELL PROLIFERATION
    SANDRA HASLAM; Fiscal Year: 2007
    ..The long-term goal of this proposal is the delineation of the mechanisms of P-dependent growth regulation in the adult normal mammary gland that may lead to novel strategies for the prevention and treatment of breast cancer. ..
  67. FUNCTION OF THE CALCIUM SENSING RECEPTOR IN THE BREAST
    John Wysolmerski; Fiscal Year: 2009
    ..We believe that these studies will deepen our understanding of the physiology of the CaR and will contribute to an understanding of both osteoporosis and bone metastases in patients with breast cancer. ..
  68. MECHANISMS OF CELL CYCLE CONTROL DURING MAMMARY GLAND DE
    Hui Zhang; Fiscal Year: 2001
    ..These studies should also provide a basis to design novel strategies for diagnosis, prognosis, and therapeutic treatment of breast cancers. ..
  69. GENETIC AND BIOCHEMICAL DISSECTION OF PROLACTIN ACTIONS
    NELSON HORSEMAN; Fiscal Year: 2006
    ..These models will allow us to examine the role of mammary-expressed TPH in development and physiology in animals that have interruptions in their autocrine/paracrine 5-HT exposure. ..
  70. Prenatal xenoestrogen exposure and mammary cancer
    ANA SOTO; Fiscal Year: 2006
    ..It may even influence public policy about prevention. ..
  71. Role of receptor tyrosine kinase signaling in branching morphogenesis
    PENGFEI PAUL LU; Fiscal Year: 2010
    ..If deregulation of RTK signaling could be prevented then we would greatly improve therapeutic interventions of human congenital illnesses inflicting the above epithelial organs and save the lives of millions of patients. ..
  72. HORMONE REGULATED INVOLUTION SIGNALED THROUGH E CADHERIN
    Mark Day; Fiscal Year: 2003
    ..abstract_text> ..
  73. HIGH RESOLUTION DNASE I HYPERSENSITIVE SITE MAPPING IN MAMMARY GLAND DEVELOPMENT
    Monique Rijnkels; Fiscal Year: 2009
    ..These studies will provide a foundation for understanding the mechanisms that determine the functional capacity of the mother's gland. ..