nonmammalian embryo

Summary

Summary: The embryo of species other than mammals. For the chicken, use the specific CHICK EMBRYO.

Top Publications

  1. pmc p53 activation by knockdown technologies
    Mara E Robu
    University of Minnesota, Minneapolis, Minnesota, United States of America
    PLoS Genet 3:e78. 2007
  2. ncbi Controlling morpholino experiments: don't stop making antisense
    Judith S Eisen
    Institute of Neuroscience, 1254 University of Oregon, Eugene, OR 97403 1254, USA
    Development 135:1735-43. 2008
  3. doi High-resolution in situ hybridization to whole-mount zebrafish embryos
    Christine Thisse
    Department of Cell Biology, University of Virginia Health Sciences Center, PO Box 800732, 1300 Jefferson Park Avenue, Charlottesville, Virginia 22908, USA
    Nat Protoc 3:59-69. 2008
  4. ncbi MicroRNA expression in zebrafish embryonic development
    Erno Wienholds
    Hubrecht Laboratory, Centre for Biomedical Genetics, 3584 CT Utrecht, The Netherlands
    Science 309:310-1. 2005
  5. ncbi Silberblick/Wnt11 mediates convergent extension movements during zebrafish gastrulation
    C P Heisenberg
    Department of Anatomy and Developmental Biology, University College, London, UK
    Nature 405:76-81. 2000
  6. doi Control of chemokine-guided cell migration by ligand sequestration
    Bijan Boldajipour
    Center for Molecular Biology of Inflammation, Von Esmarch Strasse 56, D 48149 Munster, Germany
    Cell 132:463-73. 2008
  7. pmc Live imaging of wound inflammation in Drosophila embryos reveals key roles for small GTPases during in vivo cell migration
    Brian Stramer
    Department of Physiology, School of Medical Sciences, University of Bristol, Bristol, BS8 1TD, UK
    J Cell Biol 168:567-73. 2005
  8. ncbi Cellular and molecular analyses of vascular tube and lumen formation in zebrafish
    Suk Won Jin
    Department of Biochemistry and Biophysics and Cardiovascular Research Institute, Program in Developmental Biology, University of California San Francisco, 1550 Fourth Street, San Francisco, CA 94143, USA
    Development 132:5199-209. 2005
  9. pmc Loss of myotubularin function results in T-tubule disorganization in zebrafish and human myotubular myopathy
    James J Dowling
    Department of Pediatrics, University of Michigan Medical Center, Ann Arbor, Michigan, USA
    PLoS Genet 5:e1000372. 2009
  10. doi Fgf8 morphogen gradient forms by a source-sink mechanism with freely diffusing molecules
    Shuizi Rachel Yu
    Developmental Genetics, Biotechnology Center, TUD, Tatzberg 47 49, 01307 Dresden, Germany
    Nature 461:533-6. 2009

Detail Information

Publications295 found, 100 shown here

  1. pmc p53 activation by knockdown technologies
    Mara E Robu
    University of Minnesota, Minneapolis, Minnesota, United States of America
    PLoS Genet 3:e78. 2007
    ..p53 inhibition could potentially be applicable to other systems to suppress off-target effects caused by other knockdown technologies...
  2. ncbi Controlling morpholino experiments: don't stop making antisense
    Judith S Eisen
    Institute of Neuroscience, 1254 University of Oregon, Eugene, OR 97403 1254, USA
    Development 135:1735-43. 2008
    ..We also discuss how the use of morpholinos can lead to misleading results, including off-target effects, and we suggest controls that will allow researchers to interpret morpholino experiments correctly...
  3. doi High-resolution in situ hybridization to whole-mount zebrafish embryos
    Christine Thisse
    Department of Cell Biology, University of Virginia Health Sciences Center, PO Box 800732, 1300 Jefferson Park Avenue, Charlottesville, Virginia 22908, USA
    Nat Protoc 3:59-69. 2008
    ..The whole procedure takes only 3 days and, because ISH conditions are the same for each probe tested, allows high throughput analysis of zebrafish gene expression during embryogenesis...
  4. ncbi MicroRNA expression in zebrafish embryonic development
    Erno Wienholds
    Hubrecht Laboratory, Centre for Biomedical Genetics, 3584 CT Utrecht, The Netherlands
    Science 309:310-1. 2005
    ....
  5. ncbi Silberblick/Wnt11 mediates convergent extension movements during zebrafish gastrulation
    C P Heisenberg
    Department of Anatomy and Developmental Biology, University College, London, UK
    Nature 405:76-81. 2000
    ..Our results provide genetic and experimental evidence that Wnt activity in lateral tissues has a crucial role in driving the convergent extension movements underlying vertebrate gastrulation...
  6. doi Control of chemokine-guided cell migration by ligand sequestration
    Bijan Boldajipour
    Center for Molecular Biology of Inflammation, Von Esmarch Strasse 56, D 48149 Munster, Germany
    Cell 132:463-73. 2008
    ....
  7. pmc Live imaging of wound inflammation in Drosophila embryos reveals key roles for small GTPases during in vivo cell migration
    Brian Stramer
    Department of Physiology, School of Medical Sciences, University of Bristol, Bristol, BS8 1TD, UK
    J Cell Biol 168:567-73. 2005
    ..Cdc42 is necessary for maintaining cellular polarity and yet, despite in vitro evidence, is dispensable for sensing and crawling toward wound cues...
  8. ncbi Cellular and molecular analyses of vascular tube and lumen formation in zebrafish
    Suk Won Jin
    Department of Biochemistry and Biophysics and Cardiovascular Research Institute, Program in Developmental Biology, University of California San Francisco, 1550 Fourth Street, San Francisco, CA 94143, USA
    Development 132:5199-209. 2005
    ..These studies provide the tools and a cellular framework for the investigation of mutations affecting vasculogenesis in zebrafish...
  9. pmc Loss of myotubularin function results in T-tubule disorganization in zebrafish and human myotubular myopathy
    James J Dowling
    Department of Pediatrics, University of Michigan Medical Center, Ann Arbor, Michigan, USA
    PLoS Genet 5:e1000372. 2009
    ..Based on our findings, we speculate that congenital myopathies, usually considered entities with similar clinical features but very disparate pathomechanisms, may at their root be disorders of calcium homeostasis...
  10. doi Fgf8 morphogen gradient forms by a source-sink mechanism with freely diffusing molecules
    Shuizi Rachel Yu
    Developmental Genetics, Biotechnology Center, TUD, Tatzberg 47 49, 01307 Dresden, Germany
    Nature 461:533-6. 2009
    ..Our results demonstrate that a freely diffusing morphogen can set up concentration gradients in a complex multicellular tissue by a simple source-sink mechanism...
  11. ncbi Drosophila melanogaster embryonic haemocytes: masters of multitasking
    Will Wood
    Department of Biology and Biochemistry, University of Bath, BA2 7AY, UK
    Nat Rev Mol Cell Biol 8:542-51. 2007
    ..Instead, throughout development, embryonic haemocytes are occupied with other tasks: they undergo complex migrations and carry out several non-immune functions that are crucial for successful embryogenesis...
  12. ncbi Vertebrate Smoothened functions at the primary cilium
    Kevin C Corbit
    Developmental and Stem Cell Biology Program, University of California, San Francisco, California 94143, USA
    Nature 437:1018-21. 2005
    ..Thus, Hh-dependent translocation to cilia is essential for Smo activity, suggesting that Smo acts at the primary cilium...
  13. pmc RNA polymerase stalling at developmental control genes in the Drosophila melanogaster embryo
    Julia Zeitlinger
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nat Genet 39:1512-6. 2007
    ..We propose that Pol II stalling facilitates rapid temporal and spatial changes in gene activity during development...
  14. ncbi Zebrafish as a model organism for the identification and characterization of drugs and genes affecting p53 signaling
    Ulrike Langheinrich
    Exelixis Deutschland GmbH, Spemannstrasse 35, D 72076 Tubingen, Germany
    Curr Biol 12:2023-8. 2002
    ..We conclude that zebrafish represents a promising model organism for future compound-based and genetic screens and believe that it will help to identify and characterize new anticancer drugs and new targets for cancer treatment...
  15. ncbi Transgenesis and gene trap methods in zebrafish by using the Tol2 transposable element
    Koichi Kawakami
    Division of Molecular and Developmental Biology, National Institute of Genetics, Mishima, Shizuoka 411 8540, Japan
    Methods Cell Biol 77:201-22. 2004
  16. ncbi Zebrafish MiR-430 promotes deadenylation and clearance of maternal mRNAs
    Antonio J Giraldez
    Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, and Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA
    Science 312:75-9. 2006
    ..We also show that miR-430 accelerates the deadenylation of target mRNAs. These results suggest that miR-430 facilitates the deadenylation and clearance of maternal mRNAs during early embryogenesis...
  17. pmc CHD1 motor protein is required for deposition of histone variant H3.3 into chromatin in vivo
    Alexander Y Konev
    Department of Cell Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Science 317:1087-90. 2007
    ..Furthermore, our results point to the general requirement of adenosine triphosphate (ATP)-utilizing motor proteins for histone deposition in vivo...
  18. ncbi sonic hedgehog and vascular endothelial growth factor act upstream of the Notch pathway during arterial endothelial differentiation
    Nathan D Lawson
    Laboratory of Molecular Genetics, NICHD, NIH, Bethesda, MD 20892, USA
    Dev Cell 3:127-36. 2002
    ..These studies reveal a complex signaling cascade responsible for establishing arterial cell fate and suggest differential effects of Vegf on developing endothelial cells...
  19. ncbi Zebrafish pea3 and erm are general targets of FGF8 signaling
    H Roehl
    Max Planck Institut fur Entwicklungsbiologie, Spemannstrasse 35 III, D 72076, Tubingen, Germany
    Curr Biol 11:503-7. 2001
    ..To test whether this differential expression is established by FGF8, we have induced FGF8 ectopically and show that it is sufficient to recapitulate the endogenous nested expression pattern of pea3 and erm...
  20. pmc Multiple forces contribute to cell sheet morphogenesis for dorsal closure in Drosophila
    D P Kiehart
    Department of Cell Biology, Cell and Molecular Biology Program, University Program in Genetics and the Duke Comprehensive Cancer Center, Duke University Medical Center, Durham, North Carolina 27710 3709, USA
    J Cell Biol 149:471-90. 2000
    ..Moreover, our observations demonstrate that wound healing in this insect epidermal system parallel wound healing in vertebrate tissues in situ and vertebrate cells in culture (for review see Kiehart, D.P. 1999. Curr. Biol. 9:R602-R605)...
  21. ncbi Mechanisms of asymmetric cell division: flies and worms pave the way
    PIERRE GONCZY
    Swiss Institute for Experimental Cancer Research ISREC, Swiss Federal Institute of Technology EPFL, School of Life Sciences, Lausanne, Switzerland
    Nat Rev Mol Cell Biol 9:355-66. 2008
    ..Lessons learned from these two model organisms also apply to cells that divide asymmetrically in other metazoans, such as self-renewing stem cells in mammals...
  22. ncbi Directional migration of neural crest cells in vivo is regulated by Syndecan-4/Rac1 and non-canonical Wnt signaling/RhoA
    Helen K Matthews
    Department of Anatomy and Development Biology, University College London, Gower Street, London WC1E 6BT, UK
    Development 135:1771-80. 2008
    ..In addition, we show that RhoA inhibits Rac in NC cells. We present a model in which Syn4 and PCP control directional NC migration by, at least in part, regulating membrane protrusions through the regulation of small GTPase activities...
  23. pmc Sepsid even-skipped enhancers are functionally conserved in Drosophila despite lack of sequence conservation
    Emily E Hare
    Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, California, United States of America
    PLoS Genet 4:e1000106. 2008
    ..Together, these observations suggest that the local arrangement of binding sites relative to each other is more important than their overall arrangement into larger units of cis-regulatory function...
  24. pmc Gastrulation in Drosophila: the logic and the cellular mechanisms
    M Leptin
    Institut fur Genetik, Universitat zu Koln, Weyertal 121, D 50931 Köln, Germany
    EMBO J 18:3187-92. 1999
    ....
  25. pmc Pcl-PRC2 is needed to generate high levels of H3-K27 trimethylation at Polycomb target genes
    Maxim Nekrasov
    Gene Expression Programme, EMBL, Heidelberg, Germany
    EMBO J 26:4078-88. 2007
    ..Pcl-PRC2 is thus the HMTase that generates the high levels of H3-K27 trimethylation in Polycomb target genes that are needed to maintain a Polycomb-repressed chromatin state...
  26. ncbi Fgf10 regulates hepatopancreatic ductal system patterning and differentiation
    P Duc Si Dong
    Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics and Human Genetics, and the Diabetes Center, University of California, San Francisco, 1550 Fourth Street, San Francisco, California 94158, USA
    Nat Genet 39:397-402. 2007
    ..These data shed light onto how the multipotent cells of the foregut endoderm, and subsequently those of the hepatopancreatic duct, are directed toward different organ fates...
  27. ncbi Multicellular rosette formation links planar cell polarity to tissue morphogenesis
    J Todd Blankenship
    Developmental Biology Program, Sloan Kettering Institute, New York, New York 10021, USA
    Dev Cell 11:459-70. 2006
    ..We propose that the generation of higher-order rosette structures links local cell interactions to global tissue reorganization during morphogenesis...
  28. pmc The chromokinesin, KLP3A, dives mitotic spindle pole separation during prometaphase and anaphase and facilitates chromatid motility
    Mijung Kwon
    University of California Davis, Davis, California 95616, USA
    Mol Biol Cell 15:219-33. 2004
    ..We propose that KLP3A acts on MTs associated with chromosome arms and the central spindle to organize ipMT bundles, to drive spindle pole separation and to facilitate chromatid motility...
  29. ncbi Pax6 induces ectopic eyes in a vertebrate
    R L Chow
    Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, New York University Medical Center, New York, NY 10016, USA
    Development 126:4213-22. 1999
    ..These data show that in vertebrates, as in the invertebrate Drosophila melanogaster, Pax6 is both necessary and sufficient to trigger the cascade of events required for eye formation...
  30. pmc Efficient transposition of the Tol2 transposable element from a single-copy donor in zebrafish
    Akihiro Urasaki
    Division of Molecular and Developmental Biology, National Institute of Genetics, and Department of Genetics, Graduate University for Advanced Studies SOKENDAI, Mishima, Shizuoka 411 8540, Japan
    Proc Natl Acad Sci U S A 105:19827-32. 2008
    ..Our present study demonstrates that the in vivo Tol2 transposition system is useful for creating genome-wide insertions from a single-copy donor and should facilitate functional genomics and transposon biology in vertebrates...
  31. ncbi Zebrafish Rho kinase 2 acts downstream of Wnt11 to mediate cell polarity and effective convergence and extension movements
    Florence Marlow
    Department of Biological Sciences, Vanderbilt University, VU Station B 351634, Nashville, TN 37235 1634, USA
    Curr Biol 12:876-84. 2002
    ..Moreover, how defective mediolateral cell polarity impacts CE is not understood...
  32. ncbi A role for FGF-8 in the dorsoventral patterning of the zebrafish gastrula
    M Fürthauer
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS, INSERM, ULP, Illkirch, France
    Development 124:4253-64. 1997
    ..We conclude that FGF-8 is involved in defining dorsoventral identity and is an important organizing factor responsible for specification of mesodermal and ectodermal dorsolateral territories of the zebrafish gastrula...
  33. ncbi Presynaptic development at the Drosophila neuromuscular junction: assembly and localization of presynaptic active zones
    A Prokop
    Department of Zoology, University of Cambridge, United Kingdom
    Neuron 17:617-26. 1996
    ..Thus, the process of synapse formation can be genetically separated from the process of target recognition, revealing that localization of presynaptic active zones requires mef2-dependent muscle differentiation...
  34. ncbi Characterization of a notochord-specific enhancer from the Brachyury promoter region of the ascidian, Ciona intestinalis
    J C Corbo
    Department of Biology, University of California, San Diego, La Jolla 92093 0347, USA
    Development 124:589-602. 1997
    ..We discuss the implications of this analysis with regard to the evolutionary conservation of integrative enhancers, and the subdivision of the axial and paraxial mesoderm in vertebrates...
  35. pmc FoxH1 negatively modulates flk1 gene expression and vascular formation in zebrafish
    Jayoung Choi
    Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA 90095, USA
    Dev Biol 304:735-44. 2007
    ..Taken together, our data provide the first evidence that flk1 is a direct target of FoxH1 and that FoxH1 is involved in vessel formation in zebrafish...
  36. ncbi A role for Piwi and piRNAs in germ cell maintenance and transposon silencing in Zebrafish
    Saskia Houwing
    Hubrecht Laboratory, Uppsalalaan 8, Utrecht, Netherlands
    Cell 129:69-82. 2007
    ..Furthermore, we show that piRNAs are Dicer independent and that their 3' end likely carries a 2'O-Methyl modification...
  37. pmc Dishevelled controls apical docking and planar polarization of basal bodies in ciliated epithelial cells
    Tae Joo Park
    Department of Molecular Cell and Developmental Biology and Institute for Cellular and Molecular Biology, University of Texas, Austin, Texas 78712, USA
    Nat Genet 40:871-9. 2008
    ..These results demonstrate previously undescribed functions for PCP signaling components and suggest that a common signaling apparatus governs both apical docking and planar polarization of basal bodies...
  38. ncbi p53-dependent neuronal cell death in a DJ-1-deficient zebrafish model of Parkinson's disease
    Sandrine Bretaud
    Centre for Developmental and Biomedical Genetics, University of Sheffield, Sheffield, UK
    J Neurochem 100:1626-35. 2007
    ..Our study demonstrates the utility of zebrafish as a new animal model to study PD gene defects and suggests that modulation of downstream mechanisms, such as p53 inhibition, may be of therapeutic benefit...
  39. pmc Quantitative transcript imaging in normal and heat-shocked Drosophila embryos by using high-density oligonucleotide arrays
    R Leemans
    Institute of Zoology, Biocenter Pharmacenter, University of Basel, CH 4056 Basel, Switzerland
    Proc Natl Acad Sci U S A 97:12138-43. 2000
    ..These results demonstrate that high-density oligonucleotide arrays are sensitive, efficient, and quantitative instruments for the analysis of large scale gene expression in Drosophila embryos...
  40. pmc Dynamic analysis of filopodial interactions during the zippering phase of Drosophila dorsal closure
    Thomas H Millard
    Department of Biochemistry, School of Medical Sciences, University of Bristol, University Walk, Bristol BS8 1DA, UK
    Development 135:621-6. 2008
    ..Finally, we characterise the behaviour of a patched-expressing cell that we observe within the engrailed region of segments A1-A5, and provide evidence that this cell contributes to cell matching...
  41. ncbi Segmentation
    Diethard Tautz
    Institut für Genetik der Universität zu Köln, Weyertal 121, 50931, Germany
    Dev Cell 7:301-12. 2004
    ..An old concept of comparative anatomy, the enterocoele theory, is compatible with a single origin of segmentation mechanisms and could therefore provide a conceptual framework for assessing these molecular similarities...
  42. ncbi Cranio-lenticulo-sutural dysplasia is caused by a SEC23A mutation leading to abnormal endoplasmic-reticulum-to-Golgi trafficking
    Simeon A Boyadjiev
    McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nat Genet 38:1192-7. 2006
    ..Our observations suggest that disrupted endoplasmic reticulum export of the secretory proteins required for normal morphogenesis accounts for CLSD...
  43. doi Silencing of Smed-betacatenin1 generates radial-like hypercephalized planarians
    Marta Iglesias
    Departament de Genetica, Universitat de Barcelona, 08028 Barcelona, Spain
    Development 135:1215-21. 2008
    ..mediterranea beta-catenins could be functionally specialized and that only Smed-betacatenin1 is involved in Wnt signalling...
  44. pmc Formation of the bicoid morphogen gradient: an mRNA gradient dictates the protein gradient
    Alexander Spirov
    Center for Developmental Genetics, Stony Brook University, Stony Brook, NY 11794 5140, USA
    Development 136:605-14. 2009
    ....
  45. ncbi The zebrafish spi1 promoter drives myeloid-specific expression in stable transgenic fish
    Alister C Ward
    Centre for Cellular and Molecular Biology, School of Biological and Chemical Sciences, Deakin University, Burwood, Victoria, Australia
    Blood 102:3238-40. 2003
    ..These TG(spi1:EGFP)pA301 transgenic zebrafish represent a valuable tool for further studies of myeloid development and its perturbation...
  46. ncbi Primary culture of Caenorhabditis elegans developing embryo cells for electrophysiological, cell biological and molecular studies
    Kevin Strange
    Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Nat Protoc 2:1003-12. 2007
    ..Cultured embryo cells are well suited for physiological analysis as well as molecular and cell biological studies. The embryo cell isolation protocol can be completed in 5-6 h...
  47. ncbi Neurodevelopmental defects in zebrafish (Danio rerio) at environmentally relevant dioxin (TCDD) concentrations
    Adrian Hill
    Laboratory for Environmental Gene Regulation, School of Biological Sciences, Biosciences Building, University of Liverpool, Crown Street, Liverpool Merseyside L69 7ZB, United Kingdom
    Toxicol Sci 76:392-9. 2003
    ..This disruption of neuronal development provides the basis for understanding the neurotoxic effects of these compounds...
  48. ncbi Comm function in commissural axon guidance: cell-autonomous sorting of Robo in vivo
    Krystyna Keleman
    Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Dr Bohr Gasse 3 5, A 1030 Vienna, Austria
    Nat Neurosci 8:156-63. 2005
    ..We show here, however, that ubiquitination of Comm is not required for its function in vitro or in vivo, and that Nedd4 is unlikely to function in axon guidance at the midline...
  49. ncbi Whole-somite rotation generates muscle progenitor cell compartments in the developing zebrafish embryo
    Georgina E Hollway
    The Victor Chang Cardiac Research Institute, 384 Victoria Street, Darlinghurst, New South Wales 2010, Australia
    Dev Cell 12:207-19. 2007
    ..We also show that formation of this compartment occurs via whole-somite rotation, a process that requires the action of the Sdf family of secreted cytokines...
  50. ncbi Cortical flows powered by asymmetrical contraction transport PAR proteins to establish and maintain anterior-posterior polarity in the early C. elegans embryo
    Edwin Munro
    Center for Cell Dynamics, Friday Harbor, WA 98250, USA
    Dev Cell 7:413-24. 2004
    ..Similar actomyosin flows accompany the establishment of PAR asymmetries that form after the one-cell stage, suggesting that actomyosin-mediated cortical flows have a general role in PAR asymmetry...
  51. ncbi Scl is required for dorsal aorta as well as blood formation in zebrafish embryos
    Lucy J Patterson
    Weatherall Institute of Molecular Medicine, Oxford University, John Radcliffe Hospital, Headington, Oxford, OX3 9DS, United Kingdom
    Blood 105:3502-11. 2005
    ..We conclude that scl is especially critical for the development of arteries where adult hematopoietic stem cells emerge, implicating scl in the formation of hemogenic endothelium...
  52. ncbi Exploring embryonic germ line development in the water flea, Daphnia magna, by zinc-finger-containing VASA as a marker
    Kazunori Sagawa
    School of Life Science, Tokyo University of Pharmacy and Life Science, Hachioji, Japan
    Gene Expr Patterns 5:669-78. 2005
    ..RNA analyses suggested that maternally supplied vasa mRNA was responsible for early VASA expression, while zygotic expression started during blastodermal stage of development...
  53. ncbi Multiplex detection of RNA expression in Drosophila embryos
    Dave Kosman
    Section of Cell and Developmental Biology, University of California San Diego, La Jolla, CA 92093, USA
    Science 305:846. 2004
    ....
  54. pmc The role of the segmentation gene hairy in Tribolium
    Manuel Aranda
    Department of Genetics, University of Cologne, Zülpicherstrasse 47, 50674, Koln, Germany
    Dev Genes Evol 218:465-77. 2008
    ..Our results imply that there is considerable divergence in hairy function between Tribolium and Drosophila...
  55. pmc How the Dorsal gradient works: insights from postgenome technologies
    Joung Woo Hong
    Division of Genetics, Genomics, and Development, Department of Molecular and Cell Biology, Center for Integrative Genomics, University of California, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 105:20072-6. 2008
    ..The identification of 60-70 Dorsal target genes, along with the characterization of approximately 35 associated regulatory DNAs, suggests that there are at least six different regulatory codes driving diverse DV expression profiles...
  56. ncbi Postsynaptic filopodia in muscle cells interact with innervating motoneuron axons
    S Ritzenthaler
    Department of Cell and Structural Biology, University of Illinois, B605 CLS Laboratory, 601 South Goodwin Ave, Urbana, Illinois 61801, USA
    Nat Neurosci 3:1012-7. 2000
    ..Thus, postsynaptic filopodia are capable of intimate interaction with innervating presynaptic axons. We propose that, by contributing to direct long-distance cellular communication, they are dynamically involved in synaptic matchmaking...
  57. pmc Cell cycle control of chorion gene amplification
    B R Calvi
    Howard Hughes Medical Institute Research Laboratories, Carnegie Institution of Washington, Baltimore, Maryland 21210, USA
    Genes Dev 12:734-44. 1998
    ..Our findings suggest that chorion amplification is a model for understanding metazoan replicons and the controls that restrict replication to once per cell cycle...
  58. pmc The A- and B-type cyclins of Drosophila are accumulated and destroyed in temporally distinct events that define separable phases of the G2-M transition
    W G Whitfield
    Department of Biochemistry, The University, Dundee, Scotland
    EMBO J 9:2563-72. 1990
    ..These observations suggest that cyclin A has a role in the G2-M transition that is independent of spindle formation, and that entry into anaphase is a key requirement for the degradation of cyclin B...
  59. ncbi Characterization of zebrafish mutants with defects in embryonic hematopoiesis
    D G Ransom
    Max Planck Institut für Entwickslungbiologie, Abteilung Genetik, Tubingen, Germany
    Development 123:311-9. 1996
    ..The analysis of these mutants provides a powerful approach towards defining the molecular mechanisms involved in vertebrate hematopoietic development...
  60. ncbi Activation of transcription in Drosophila embryos is a gradual process mediated by the nucleocytoplasmic ratio
    D K Pritchard
    Department of Genetics, University of Washington, Seattle, Washington, USA
    Genes Dev 10:1131-42. 1996
    ....
  61. pmc Whole-genome ChIP-chip analysis of Dorsal, Twist, and Snail suggests integration of diverse patterning processes in the Drosophila embryo
    Julia Zeitlinger
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, Massachusetts 02142, USA
    Genes Dev 21:385-90. 2007
    ..Thus, the ChIP-chip data uncover a much larger than expected regulatory network, which integrates diverse patterning processes during development...
  62. ncbi Gateway compatible vectors for analysis of gene function in the zebrafish
    Jacques A Villefranc
    Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Dev Dyn 236:3077-87. 2007
    ..Taken together, this work provides an important platform for the rapid functional analyses of open reading frames in zebrafish embryos...
  63. ncbi rst and its paralogue kirre act redundantly during embryonic muscle development in Drosophila
    M Strünkelnberg
    Institut fur Biologie III, Schänzlestr 1, Albert Ludwigs Universitat, D 79104 Freiburg im Breisgau, Germany
    Development 128:4229-39. 2001
    ..This defect can be rescued by one copy of either gene. Moreover, Rst, like Kirre is a myoblast attractant...
  64. ncbi XCtBP is a XTcf-3 co-repressor with roles throughout Xenopus development
    M Brannon
    Department of Biochemistry, Howard Hughes Medical Institute, Center for Developmental Biology, University of Washington School of Medicine, Seattle, Washington 98195 7350, USA
    Development 126:3159-70. 1999
    ..Our data support a role for XCtBP as a co-repressor throughout Xenopus development and indicate that XCtBP/G4A will be a useful tool in determining how XCtBP functions in various developmental processes...
  65. ncbi Analysis of genetic mosaics in developing and adult Drosophila tissues
    T Xu
    Howard Hughes Medical Institute, University of California, Berkeley 94720
    Development 117:1223-37. 1993
    ....
  66. ncbi Croquemort, a novel Drosophila hemocyte/macrophage receptor that recognizes apoptotic cells
    N C Franc
    Division of Hematology, Children s Hospital, Boston, Massachusetts 02115, USA
    Immunity 4:431-43. 1996
    ..Our findings support the idea that the primordial function of macrophages may have been in tissue modeling and that their adapted role is in host defense...
  67. pmc CD41+ cmyb+ precursors colonize the zebrafish pronephros by a novel migration route to initiate adult hematopoiesis
    Julien Y Bertrand
    Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093 0380, USA
    Development 135:1853-62. 2008
    ..Together, these studies suggest that expression of CD41 and cmyb marks nascent HSCs in the zebrafish AGM, and provide the means to further dissect HSC generation and function in the early vertebrate embryo...
  68. ncbi TAF1 activates transcription by phosphorylation of serine 33 in histone H2B
    Tobias Maile
    Department of Biochemistry, University of California Riverside, Riverside, CA 95121, USA
    Science 304:1010-4. 2004
    ..These data reveal that H2B-S33 is a physiological substrate for the TAF1 CTK and that H2B-S33 phosphorylation is essential for transcriptional activation events that promote cell cycle progression and development...
  69. pmc Chk1 suppresses a caspase-2 apoptotic response to DNA damage that bypasses p53, Bcl-2, and caspase-3
    Samuel Sidi
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Cell 133:864-77. 2008
    ..The evolutionarily conserved "Chk1-suppressed" pathway defines a novel apoptotic process, whose responsiveness to Chk1 inhibitors and insensitivity to p53 and BCL2 alterations have important implications for cancer therapy...
  70. ncbi Zebrafish embryos as models for embryotoxic and teratological effects of chemicals
    Lixin Yang
    Institute of Toxicology and Genetics, Forschungszentrum Karlsruhe in the Helmholtz Association, Karlsruhe Institute of Technology, PO Box 3640, Karlsruhe 76021, Germany
    Reprod Toxicol 28:245-53. 2009
    ....
  71. ncbi The protooncogene c-myc is an essential regulator of neural crest formation in xenopus
    Amy Bellmeyer
    Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, IL 60208, USA
    Dev Cell 4:827-39. 2003
    ..These effects are not dependent upon changes in cell proliferation or cell death. Instead, our findings reveal an important and unexpected role for c-Myc in the specification of cell fates in the early ectoderm...
  72. pmc Regulation of neurogenesis by interkinetic nuclear migration through an apical-basal notch gradient
    Filippo Del Bene
    Department of Physiology, Programs in Neuroscience, Genetics, and Developmental Biology, University of California San Francisco, San Francisco, CA 94158 2722, USA
    Cell 134:1055-65. 2008
    ..Our data indicate that the function of INM is to balance the exposure of progenitor nuclei to neurogenic versus proliferative signals...
  73. pmc Regulation of cytokinesis by Rho GTPase flux
    Ann L Miller
    Department of Zoology, University of Wisconsin Madison, Madison, WI 53706, USA
    Nat Cell Biol 11:71-7. 2009
    ....
  74. ncbi Zinc transporter LIVI controls epithelial-mesenchymal transition in zebrafish gastrula organizer
    Susumu Yamashita
    Laboratory of Developmental Immunology, Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka 565 0871, Japan
    Nature 429:298-302. 2004
    ..Furthermore, we demonstrate that LIV1 is essential for the nuclear localization of zinc-finger protein Snail, a master regulator of EMT. These results establish a molecular link between STAT3, LIV1 and Snail in EMT...
  75. pmc Distinct mechanisms regulate hemocyte chemotaxis during development and wound healing in Drosophila melanogaster
    Will Wood
    Instituto Gulbenkian de Ciencia, 2780 156 Oeiras, Portugal
    J Cell Biol 173:405-16. 2006
    ....
  76. ncbi Fgf8 drives myogenic progression of a novel lateral fast muscle fibre population in zebrafish
    Julie A Groves
    MRC Centre for Developmental Neurobiology and Randall Division for Cell and Molecular Biophysics, New Hunt s House, King s College London, London SE1 1UL, UK
    Development 132:4211-22. 2005
    ..We conclude that Fgf8 drives terminal differentiation of a specific population of lateral muscle precursor cells within the early somite...
  77. ncbi The specification of dorsal cell fates in the vertebrate central nervous system
    K J Lee
    Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Center for Neurobiology and Behavior, Columbia University, New York, New York 10032, USA
    Annu Rev Neurosci 22:261-94. 1999
    ..Additional signals involving members of the Wnt and fibroblast growth factor (FGF) families may also contribute to the proliferation and differentiation of dorsal neuronal cell types...
  78. ncbi Mechanisms of Wnt signaling in development
    A Wodarz
    Institut fur Genetik, Universitat Dusseldorf, Germany
    Annu Rev Cell Dev Biol 14:59-88. 1998
    ..Here we review recent data that have started to unravel the mechanisms of Wnt signaling...
  79. ncbi RIC-8 is required for GPR-1/2-dependent Galpha function during asymmetric division of C. elegans embryos
    Katayoun Afshar
    Swiss Institute for Experimental Cancer Research ISREC, 1066 Epalinges Lausanne, Switzerland
    Cell 119:219-30. 2004
    ..Our findings suggest a mechanism in which RIC-8 favors generation of Galpha free from Gbetagamma and enables GPR-1/2 to mediate asymmetric cell division...
  80. doi A quantitative spatiotemporal atlas of gene expression in the Drosophila blastoderm
    Charless C Fowlkes
    Berkeley Drosophila Transcription Network Project, University of California, Irvine, CA 92697, USA
    Cell 133:364-74. 2008
    ..We present a VirtualEmbryo containing data for 95 genes at six time cohorts. We show that known gene-regulatory interactions can be automatically recovered from this data set and predict hundreds of new interactions...
  81. pmc Cooperation of polarized cell intercalations drives convergence and extension of presomitic mesoderm during zebrafish gastrulation
    Chunyue Yin
    Department of Biological Sciences, Vanderbilt University, Nashville, TN 37235, USA
    J Cell Biol 180:221-32. 2008
    ....
  82. pmc Indirect effects of ploidy suggest X chromosome dose, not the X:A ratio, signals sex in Drosophila
    James W Erickson
    Department of Biology, Texas A and M University, College Station, Texas, United States of America
    PLoS Biol 5:e332. 2007
    ..Our findings reiterate that correlations between X:A ratios and cell fates in other organisms need not implicate the value of the ratio as an active signal...
  83. ncbi Epigenetic memory of an active gene state depends on histone H3.3 incorporation into chromatin in the absence of transcription
    Ray Kit Ng
    Wellcome Trust Cancer Research UK Gurdon Institute, Tennis Court Road, Cambridge CB2 1QN, UK
    Nat Cell Biol 10:102-9. 2008
    ..Hence, we suggest that epigenetic memory helps to stabilize gene expression in normal development; it might also help to account for the inefficient reprogramming in some transplanted nuclei...
  84. pmc Effects of RAS on the genesis of embryonal rhabdomyosarcoma
    David M Langenau
    Stem Cell Program and Division of Hematology, Children s Hospital Boston and Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Genes Dev 21:1382-95. 2007
    ..When coupled with gene expression studies of this cell population, we propose that the zebrafish RMS cancer stem cell shares similar self-renewal programs as those found in activated satellite cells...
  85. doi Fluorescent in situ hybridization protocols in Drosophila embryos and tissues
    Eric Lecuyer
    Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada
    Methods Mol Biol 420:289-302. 2008
    ..We also describe variations of the method for RNA-RNA and RNA-protein codetection...
  86. pmc Unexpected novel relational links uncovered by extensive developmental profiling of nuclear receptor expression
    Stephanie Bertrand
    Molecular Zoology, Institut de Génomique Fonctionelle de Lyon UMR 5242 du CNRS, INRA, IFR128 Biosciences Lyon Gerland, Universite de Lyon, UCB Ecole Normale Supérieure de Lyon, France
    PLoS Genet 3:e188. 2007
    ..Altogether, this expression database of NRs provides novel routes for leading investigation into the biological function of each individual NR as well as for the study of their combinatorial regulatory circuitry within the superfamily...
  87. ncbi Induction of the Xenopus organizer: expression and regulation of Xnot, a novel FGF and activin-regulated homeo box gene
    G von Dassow
    Department of Biochemistry, University of Washington, Seattle 98195
    Genes Dev 7:355-66. 1993
    ..Our results provide experimental evidence supporting the proposed division of Spemann's organizer into independently regulated organizing centers...
  88. pmc Shaping a morphogen gradient for positional precision
    Feng He
    Division of Biomedical Informatics, Cincinnati Children s Hospital Research Foundation, Cincinnati, Ohio, USA
    Biophys J 99:697-707. 2010
    ..Our results demonstrate that the positional information provided by the wt Bcd gradient profile is highly precise and necessary for patterning precision...
  89. ncbi An epidermal barrier wound repair pathway in Drosophila is mediated by grainy head
    Kimberly A Mace
    Section of Cell and Developmental Biology, Division of Biology, University of California, San Diego, La Jolla, CA 92093, USA
    Science 308:381-5. 2005
    ..The conservation of this Grh-dependent pathway suggests that the repair of insect cuticle and mammal skin is controlled by an ancient, shared control system for constructing and healing the animal body surface barrier...
  90. ncbi RISC assembly defects in the Drosophila RNAi mutant armitage
    Yukihide Tomari
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Cell 116:831-41. 2004
    ..Our results suggest that armi is required for RISC maturation...
  91. ncbi Identification and real-time imaging of a myc-expressing neutrophil population involved in inflammation and mycobacterial granuloma formation in zebrafish
    Annemarie H Meijer
    Institute of Biology, Leiden University, Wassenaarseweg 64, 2333 AL Leiden, The Netherlands
    Dev Comp Immunol 32:36-49. 2008
    ..Using real-time confocal imaging we demonstrate that these cells migrate to sites of inflammation and are involved in innate immune responses towards infections, including Mycobacterium marinum-induced granuloma formation...
  92. pmc Normal table of postembryonic zebrafish development: staging by externally visible anatomy of the living fish
    David M Parichy
    Department of Biology, University of Washington, Seattle, Washington 91895, USA
    Dev Dyn 238:2975-3015. 2009
    ..Finally, we provide guidelines for reporting stages that provide information on both discrete and continuous changes in growth and development...
  93. ncbi Revisiting the role of the mother centriole in centriole biogenesis
    A Rodrigues-Martins
    Instituto Gulbenkian de Ciencia, Cell Cycle Regulation Laboratory, Rua da Quinta Grande, 6, P 2780 156 Oeiras, Portugal
    Science 316:1046-50. 2007
    ..The mother centriole is not a bona fide template but a platform for a set of regulatory molecules that catalyzes and regulates daughter centriole assembly...
  94. ncbi Glycogen synthase kinase-3 and dorsoventral patterning in Xenopus embryos
    X He
    Varmus Laboratory, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 374:617-22. 1995
    ..These results indicate that GSK-3 is required for ventral differentiation, and suggest that dorsal differentiation may involve the suppression of GSK-3 activity by a wingless/wnt-related signal...
  95. ncbi The Drosophila patched gene encodes a putative membrane protein required for segmental patterning
    J E Hooper
    Howard Hughes Medical Institute, University of Colorado, Boulder 80309 0347
    Cell 59:751-65. 1989
    ..The pattern of expression does not directly predict the transformation seen in ptc mutant embryos, suggesting that ptc participates in cell interactions that establish pattern within the segment...
  96. pmc Dnmt2 functions in the cytoplasm to promote liver, brain, and retina development in zebrafish
    Kunal Rai
    Howard Hughes Medical Institute, University of Utah, Salt Lake City, Utah 84112, USA
    Genes Dev 21:261-6. 2007
    ..Furthermore, zebrafish Dnmt2 methylates an RNA species of approximately 80 bases, consistent with tRNA methylation. Thus, Dnmt2 promotes zebrafish development, likely through cytoplasmic RNA methylation...
  97. pmc Inhibition of Müller glial cell division blocks regeneration of the light-damaged zebrafish retina
    Ryan Thummel
    Department of Biological Sciences and the Center for Zebrafish Research, University of Notre Dame, Notre Dame, Indiana 46556, USA
    Dev Neurobiol 68:392-408. 2008
    ....
  98. ncbi Dishevelled: a mobile scaffold catalyzing development
    Craig C Malbon
    Department of Pharmacology, State University of New York at Stony Brook, Stony Brook, New York 11794, USA
    Curr Top Dev Biol 72:153-66. 2006
    ..Much excitement awaits the elucidation of the complete set of tools in the toolbox and of the dynamic regulation of Dishevelled proteins and their interacting proteins...
  99. pmc Size control: cell proliferation does not equal growth
    T T Su
    Department of Biochemistry and Biophysics, University of California San Francisco 94143 0448, USA
    Curr Biol 8:R687-9. 1998
    ..Both classic and recent experiments confirm this simple rationale: altering proliferation produces normally sized body structures with either especially small or exceptionally large cells...
  100. doi Origin and shaping of the laterality organ in zebrafish
    Pablo Oteiza
    Laboratory of Experimental Ontogeny, Program of Anatomy and Developmental Biology, Institute of Biomedical Sciences, University of Chile, Clasificador 7 Correo 7, Santiago, Chile
    Development 135:2807-13. 2008
    ..Our results provide novel insights into the morphogenetic transformations that shape the laterality organ in zebrafish and suggest a conserved progenitor role of the surface epithelium during laterality organ formation in vertebrates...
  101. ncbi Dynamic changes in the distribution of cytoplasmic myosin during Drosophila embryogenesis
    P E Young
    Department of Cellular and Developmental Biology, Harvard University, Cambridge, MA 02138
    Development 111:1-14. 1991
    ....

Research Grants166 found, 100 shown here

  1. ANALYSIS OF PAIR OF RULE GENES IN SEQUENTIAL SEGMENTATIO
    DAVID WEISBLAT; Fiscal Year: 2000
    ..abstract_text> ..
  2. TGF-beta and axis formation in Helobdella, a lophotrochozoan
    DAVID WEISBLAT; Fiscal Year: 2009
    ..They will also contribute to understanding the cellular processes known as epithelial-to-mesenchymal transitions (EMTs), which play a critical role both in normal development and in cancer metastasis. ..
  3. TGF-beta and axis formation in Helobdella, a lophotrochozoan
    DAVID WEISBLAT; Fiscal Year: 2008
    ..They will also contribute to understanding the cellular processes known as epithelial-to-mesenchymal transitions (EMTs), which play a critical role both in normal development and in cancer metastasis. ..
  4. ANALYSIS OF PAIR OF RULE GENES IN SEQUENTIAL SEGMENTATIO
    DAVID WEISBLAT; Fiscal Year: 2001
    ..abstract_text> ..
  5. TGF-beta and axis formation in Helobdella, a lophotrochozoan
    David A Weisblat; Fiscal Year: 2010
    ..They will also contribute to understanding the cellular processes known as epithelial-to-mesenchymal transitions (EMTs), which play a critical role both in normal development and in cancer metastasis. ..
  6. TGF-beta and axis formation in Helobdella, a lophotrochozoan
    DAVID WEISBLAT; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  7. ANALYSIS OF PAIR OF RULE GENES IN SEQUENTIAL SEGMENTATIO
    DAVID WEISBLAT; Fiscal Year: 2003
    ..abstract_text> ..
  8. TGF-beta and axis formation in Helobdella, a lophotrochozoan
    David A Weisblat; Fiscal Year: 2010
    ..They will also contribute to understanding the cellular processes known as epithelial-to-mesenchymal transitions (EMTs), which play a critical role both in normal development and in cancer metastasis. ..
  9. ANALYSIS OF PAIR OF RULE GENES IN SEQUENTIAL SEGMENTATIO
    DAVID WEISBLAT; Fiscal Year: 2002
    ..abstract_text> ..
  10. ANALYSIS OF PAIR OF RULE GENES IN SEQUENTIAL SEGMENTATIO
    DAVID WEISBLAT; Fiscal Year: 2001
    ..abstract_text> ..
  11. Spiralian developmental system for the study of multipotency
    Cesar Arenas Mena; Fiscal Year: 2008
    ..The ultimate goal is to manipulate these genes and reprogram in vivo differentiated cells into multipotent stem cells. [unreadable] [unreadable] [unreadable]..
  12. Spiralian developmental system for the study of multipotency
    Cesar Arenas Mena; Fiscal Year: 2007
    ..The ultimate goal is to manipulate these genes and reprogram in vivo differentiated cells into multipotent stem cells. [unreadable] [unreadable] [unreadable]..
  13. Cadherin6 and -10 Function in Retinal Ganglion and Amacrine Cell Development
    Qin Liu; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  14. Redox-sensitive developmental pathways and gene regulatory networks
    JAMES COFFMAN; Fiscal Year: 2008
    ..Finally, the Comparative Toxicogenomics Database (CTD) at MDIBL will be used to determine the relevance of the pathways discovered in sea urchins to human health, and to generate hypotheses that might explain specific human diseases. ..
  15. Control of Cell Proliferation by Runx Proteins
    JAMES COFFMAN; Fiscal Year: 2009
    ..purpuratus genome sequence, which will greatly facilitate both the cis-regulatory analysis of genes and the identification of purified proteins by mass spectrometry. ..
  16. CONTROL OF EPITHELIAL SHEET MOVEMENT IN C ELEGANS
    JEFFREY HARDIN; Fiscal Year: 2001
    ..As a result of these studies, we expect to gain a greater understanding of how specific lesions in identified molecules give rise to specific cellular defects during epithelial morphogenesis. ..
  17. Control of Cell Proliferation by Runx Proteins
    JAMES COFFMAN; Fiscal Year: 2006
    ..purpuratus genome sequence, which will greatly facilitate both the cis-regulatory analysis of genes and the identification of purified proteins by mass spectrometry. ..
  18. Control of Cell Proliferation by Runx Proteins
    JAMES COFFMAN; Fiscal Year: 2007
    ..purpuratus genome sequence, which will greatly facilitate both the cis-regulatory analysis of genes and the identification of purified proteins by mass spectrometry. ..
  19. Control of Cell Proliferation by Runx Proteins
    JAMES COFFMAN; Fiscal Year: 2005
    ..purpuratus genome sequence, which will greatly facilitate both the cis-regulatory analysis of genes and the identification of purified proteins by mass spectrometry. ..
  20. Regulation of Epidermal Junctions in C. elegans
    JEFFREY HARDIN; Fiscal Year: 2005
    ..Moreover, this freely available, open-source suite will allow investigators and educators easy and inexpensive access to 4D analysis and acquisition capabilities using easily extensible, platform-independent Java technologies. ..
  21. Regulation of Epidermal Junctions in C. elegans
    JEFFREY HARDIN; Fiscal Year: 2005
    ..Because these studies will be carried out in a living organism, we will gain fundamental new insights into how these key junctional complexes regulate a fundamental morphogenetic event. ..
  22. Regulation of Epidermal Junctions in C. elegans
    JEFFREY HARDIN; Fiscal Year: 2007
    ..Because these studies will be carried out in a living organism, we will gain fundamental new insights into how these key junctional complexes regulate a fundamental morphogenetic event. [unreadable] [unreadable]..
  23. Regulation of Epidermal Junctions in C. elegans
    JEFFREY HARDIN; Fiscal Year: 2004
    ..Because these studies will be carried out in a living organism, we will gain fundamental new insights into how these key junctional complexes regulate a fundamental morphogenetic event. ..
  24. Regulation of Epidermal Junctions in C. elegans
    JEFFREY HARDIN; Fiscal Year: 2006
    ..Because these studies will be carried out in a living organism, we will gain fundamental new insights into how these key junctional complexes regulate a fundamental morphogenetic event. [unreadable] [unreadable]..
  25. Redox-sensitive developmental pathways and gene regulatory networks
    JAMES COFFMAN; Fiscal Year: 2007
    ..Finally, the Comparative Toxicogenomics Database (CTD) at MDIBL will be used to determine the relevance of the pathways discovered in sea urchins to human health, and to generate hypotheses that might explain specific human diseases. ..
  26. CONTROL OF EPITHELIAL SHEET MOVEMENT IN C ELEGANS
    JEFFREY HARDIN; Fiscal Year: 2003
    ..As a result of these studies, we expect to gain a greater understanding of how specific lesions in identified molecules give rise to specific cellular defects during epithelial morphogenesis. ..
  27. Control of Cell Proliferation by Runx Proteins
    JAMES COFFMAN; Fiscal Year: 2008
    ..purpuratus genome sequence, which will greatly facilitate both the cis-regulatory analysis of genes and the identification of purified proteins by mass spectrometry. ..
  28. Mechanisms of Junctional Actin Recruitment in C. elegans
    JEFFREY HARDIN; Fiscal Year: 2008
    ..By studying how this protein works in living embryos, we will gain important information that can be used to understand and treat human disease. ..
  29. Redox-sensitive developmental pathways and gene regulatory networks
    JAMES COFFMAN; Fiscal Year: 2009
    ..Finally, the Comparative Toxicogenomics Database (CTD) at MDIBL will be used to determine the relevance of the pathways discovered in sea urchins to human health, and to generate hypotheses that might explain specific human diseases. ..
  30. Mechanisms of Junctional Actin Recruitment in C. elegans
    JEFFREY HARDIN; Fiscal Year: 2009
    ..By studying how this protein works in living embryos, we will gain important information that can be used to understand and treat human disease. ..
  31. CONTROL OF EPITHELIAL SHEET MOVEMENT IN C ELEGANS
    JEFFREY HARDIN; Fiscal Year: 1999
    ..As a result of these studies, we expect to gain a greater understanding of how specific lesions in identified molecules give rise to specific cellular defects during epithelial morphogenesis. ..
  32. The Molecular Basis of Serpin Function and Disfunction
    Patrick L Wintrode; Fiscal Year: 2010
    ..Polymerization of alpha-1 antitrypsin is the underlying cause of these symptoms. Determining the structure of the polymerization prone intermediate is an important step in developing therapeutic agents. ..
  33. Mechanisms of Junctional Actin Recruitment in C. elegans
    JEFFREY HARDIN; Fiscal Year: 2009
    ..By studying how this protein works in living embryos, we will gain important information that can be used to understand and treat human disease. ..
  34. CONTROL OF EPITHELIAL SHEET MOVEMENT IN C ELEGANS
    JEFFREY HARDIN; Fiscal Year: 2000
    ..As a result of these studies, we expect to gain a greater understanding of how specific lesions in identified molecules give rise to specific cellular defects during epithelial morphogenesis. ..
  35. Mechanisms of Junctional Actin Recruitment in C. elegans
    JEFFREY D HARDIN; Fiscal Year: 2010
    ..By studying how this protein works in living embryos, we will gain important information that can be used to understand and treat human disease. ..
  36. DEVELOPMENT OF THE OLFACTORY SYSTEM IN ZEBRAFISH
    KATHLEEN WHITLOCK; Fiscal Year: 2003
    ..abstract_text> ..
  37. SIGNALING CASCADES AND LOOPS IN XENOPUS OOCYTES
    JAMES FERRELL; Fiscal Year: 2003
    ..4. To determine whether regulated nuclear translocation contributes to the ultrasensitive response of p42 MAPK to upstream activators. ..
  38. HOMOZYGOUS SEA URCHIN AS A POTENTIAL RESEARCH RESOURCE
    Eric Davidson; Fiscal Year: 1999
    ..purpuratus is a heritable trait, and carry out other investigations on genetic aspects of sex in S. purpuratus. ..
  39. GENE LIBRARY RESOURCE FOR SEA URCHIN S. PURPURATUS
    Eric Davidson; Fiscal Year: 2003
    ..abstract_text> ..
  40. Whole organism transcriptional profiling of innate immune response
    Jeffrey Yoder; Fiscal Year: 2008
    ..The data generated by these methods will provide unprecedented insight into the organism based genomic response to infection, facilitating novel diagnosis, treatment and drug discovery strategies for modulating immune response. ..
  41. Regulatory Genomics: BAC-GFP Library of Control Genes
    Eric Davidson; Fiscal Year: 2007
    ..Numerous letters from outside investigators attesting interest in this facility are included as an Appendix to this application. [unreadable] [unreadable] [unreadable]..
  42. MOLECULAR AND CELLULAR BASIS OF LENS DEVELOPMENT
    Jonathan J Henry; Fiscal Year: 2010
    ....
  43. GENE LIBRARY RESOURCE FOR THE SEA URCHIN S. PURPURATUS
    Eric Davidson; Fiscal Year: 2007
    ..And we present the bioinformatics tools and databases of genomic sequence collections to the experimentalist. All of the individual goals detailed above are direct responses to this view. ..
  44. Regulatory Genomics: BAC-GFP Library of Control Genes
    Eric Davidson; Fiscal Year: 2008
    ..Numerous letters from outside investigators attesting interest in this facility are included as an Appendix to this application. ..
  45. GENE LIBRARY RESOURCE FOR SEA URCHIN S. PURPURATUS
    Eric Davidson; Fiscal Year: 2001
    ..abstract_text> ..
  46. THE ROLE OF MAP KINASE IN THE CELL CYCLE
    JAMES FERRELL; Fiscal Year: 2002
    ..Our overarching aim is to better understand the cell biology and biochemistry of oocyte maturation and early embryogenesis. ..
  47. Development of gonadotropin releasing hormone cells
    KATHLEEN WHITLOCK; Fiscal Year: 2006
    ....
  48. COMPUTATIONAL MODEL OF GENE REGULATORY PROGRAM
    Eric Davidson; Fiscal Year: 2002
    ..The model will ultimately constitute a quantitative computational analysis of a genomic regulatory network, defined at the DNA sequence level, the function of which is to organize a complex, major process in animal development. ..
  49. Bistability and the Mitotic Trigger
    JAMES FERRELL; Fiscal Year: 2009
    ..An understanding of the process also promises to shed light on cancer and cancer chemotherapy. ..
  50. ROLE OF MAP KINASE IN THE CELL CYCLE
    JAMES FERRELL; Fiscal Year: 1992
    ..What biological processes are mediated by MAP kinase activation? 5.What proteins are phosphorylated by MAP kinase in vivo? Our central goal is to understand how MAP kinase contributes to the cell's decision to divide...
  51. SIGNALING CASCADES AND LOOPS IN XENOPUS OOCYTES
    JAMES FERRELL; Fiscal Year: 2002
    ..4. To determine whether regulated nuclear translocation contributes to the ultrasensitive response of p42 MAPK to upstream activators. ..
  52. GENE LIBRARY RESOURCE FOR SEA URCHIN S. PURPURATUS
    Eric Davidson; Fiscal Year: 2002
    ..abstract_text> ..
  53. GENE LIBRARY RESOURCE FOR THE SEA URCHIN S. PURPURATUS
    Eric Davidson; Fiscal Year: 2006
    ..And we present the bioinformatics tools and databases of genomic sequence collections to the experimentalist. All of the individual goals detailed above are direct responses to this view. ..
  54. BIOLOGY OF BAMACAN IN TUMORIGENESIS
    Giancarlo Ghiselli; Fiscal Year: 2002
    ..3) The contribution of bamacan in vivo to colon tumorigenesis by generating transgenic mice over-expressing bamacan in the intestinal epithelium. ..
  55. HOMOZYGOUS SEA URCHIN AS A POTENTIAL RESEARCH RESOURCE
    Eric Davidson; Fiscal Year: 2003
    ..purpuratus is a heritable trait, and carry out other investigations on genetic aspects of sex in S. purpuratus. ..
  56. MAP KINASE AND THE CELL CYCLE
    JAMES FERRELL; Fiscal Year: 2001
    ..How does the MAPK cascade bring about Cdc2 activation? 4. How does activation of the MAPK cascade bring about G2 arrest in cycling extracts and embryos, and what is the significance of this arrest? ..
  57. An in vivo Screen for Radiation Sensitizers
    Tin Tin Su; Fiscal Year: 2007
    ..Successful completion of this project would establish a novel, rapid and effective primary screen in vivo for radiosensitizers with potential therapeutic value. [unreadable] [unreadable] [unreadable]..
  58. GEISHA, a Chicken Embryo Gene Expression Resource
    PARKER ANTIN; Fiscal Year: 2007
    ..This centralized repository for in situ hybridization gene expression information will provide a valuable and comprehensive resource for the biomedical research community. ..
  59. Predoctoral Fellowship for Minority Students
    Lisa Chang; Fiscal Year: 2006
    ..Some of these include microarray screening, DNA-binding assays, microinjection, microsurgery, in-situ hybridization, antisense and dominant negative inhibition of gene function, and transgenics. ..
  60. Regulation of Radiation Induced Cell Death in Drosophila
    Tin Tin Su; Fiscal Year: 2010
    ..Because of excellent conservation of gene function between Drosophila and human, what we learn may allow us to maximize the efficacy of radiation therapy of human cancers. ..
  61. Hemichordartes and the Origin of Chordates
    John Gerhart; Fiscal Year: 2006
    ..siRNA interventions will be used to evaluate the role of the encoded gene products in development. ..
  62. Regulation of Radiation Induced Cell Death in Drosophila
    Tin Tin Su; Fiscal Year: 2010
    ..Because of excellent conservation of gene function between Drosophila and human, what we learn may allow us to maximize the efficacy of radiation therapy of human cancers. ..
  63. GEISHA, a Chicken Embryo Gene Expression Resource
    PARKER ANTIN; Fiscal Year: 2009
    ..This centralized repository for in situ hybridization gene expression information will provide a valuable and comprehensive resource for the biomedical research community. ..
  64. Cell Growth and Radiation Survival in Drosophila
    Tin Tin Su; Fiscal Year: 2007
    ..Understanding radiation survival in a multicellular context could help identify potential therapies for when we do not want cells to survive irradiation, such as in the treatment of cancer. ..
  65. Hemichordartes and the Origin of Chordates
    John Gerhart; Fiscal Year: 2009
    ..siRNA interventions will be used to evaluate the role of the encoded gene products in development. ..
  66. In Vivo Analysis of the Mechanisms of Neural Crest Migration
    Paul Kulesa; Fiscal Year: 2009
    ....
  67. Regulation of Radiation Induced Cell Death in Drosophila
    Tin Tin Su; Fiscal Year: 2009
    ..Because of excellent conservation of gene function between Drosophila and human, what we learn may allow us to maximize the efficacy of radiation therapy of human cancers. ..
  68. The role of BMPR2 in blood vesel development and patterning in vivo
    Jordan Shin; Fiscal Year: 2008
    ..This study uses ZF to understand how defective BMPR2 causes disorders of blood vessel growth and function, to better understand its role in development and disease. (End of Abstract) ..
  69. Delineating the Role of FGF Signaling and Vertebrate Heart Development
    MICHAEL WAIKOK TSANG; Fiscal Year: 2010
    ..Understanding how this molecule acts to increase heart tissue is an important step towards developing potential treatment for cardiac damage caused by heart disease. ..
  70. Hemichordartes and the Origin of Chordates
    John Gerhart; Fiscal Year: 2008
    ..siRNA interventions will be used to evaluate the role of the encoded gene products in development. ..
  71. An in vivo Screen for Radiation Sensitizers
    Tin Tin Su; Fiscal Year: 2008
    ..Successful completion of this project would establish a novel, rapid and effective primary screen in vivo for radiosensitizers with potential therapeutic value. [unreadable] [unreadable] [unreadable]..
  72. GEISHA, a Chicken Embryo Gene Expression Resource
    PARKER ANTIN; Fiscal Year: 2007
    ..This centralized repository for in situ hybridization gene expression information will provide a valuable and comprehensive resource for the biomedical research community. ..
  73. GEISHA, a Chicken Embryo Gene Expression Resource
    PARKER ANTIN; Fiscal Year: 2009
    ..This centralized repository for in situ hybridization gene expression information will provide a valuable and comprehensive resource for the biomedical research community. ..
  74. GEISHA, a Chicken Embryo Gene Expression Resource
    PARKER ANTIN; Fiscal Year: 2008
    ..This centralized repository for in situ hybridization gene expression information will provide a valuable and comprehensive resource for the biomedical research community. ..
  75. Delineating the Role of FGF Signaling and Vertebrate Heart Development
    Michael Tsang; Fiscal Year: 2009
    ..Understanding how this molecule acts to increase heart tissue is an important step towards developing potential treatment for cardiac damage caused by heart disease. ..
  76. MicroRNA Gene Expression Mapping in Chicken Embryos
    PARKER ANTIN; Fiscal Year: 2007
    ..This new technology could fundamentally change the way in which in situ hybridization analyses are performed. [unreadable] [unreadable] [unreadable]..
  77. Hemichordartes and the Origin of Chordates
    John Gerhart; Fiscal Year: 2007
    ..siRNA interventions will be used to evaluate the role of the encoded gene products in development. ..
  78. In Vivo Analysis of the Mechanisms of Neural Crest Migration
    Paul M Kulesa; Fiscal Year: 2010
    ....
  79. Delineating the Role of FGF Signaling and Vertebrate Heart Development
    Michael Tsang; Fiscal Year: 2009
    ..Understanding how this molecule acts to increase heart tissue is an important step towards developing potential treatment for cardiac damage caused by heart disease. ..
  80. Cell Cycle Regulation by Checkpoints in Drosophila
    Tin Tin Su; Fiscal Year: 2006
    ..Aim 4) We will screen through existing mutagensensitive Drosophila mutants for their ability to regulate mitosis, S phase and cell death after irradiation, in order to uncover novel genes needed for proper response to DNA damage. ..
  81. Analysis of endocytosis in Caenorhabditis elegans
    Hanna Fares; Fiscal Year: 2006
    ..New genes identified in worms will also be studied in humans through collaborations with researchers who study this process. ..
  82. REGULATION OF CARDIAC MYOGENESIS
    PARKER ANTIN; Fiscal Year: 2001
    ..This information will increase our understanding of both normal and abnormal heart development and may suggest ways to alter heart development or replication of cardiac myocytes. ..
  83. Analysis of endocytosis in Caenorhabditis elegans
    Hanna Fares; Fiscal Year: 2002
    ..New genes identified in worms will also be studied in humans through collaborations with researchers who study this process. ..
  84. Hemichordates and the Origin of Chordates
    John Gerhart; Fiscal Year: 2004
    ..Knowledge of hemichordates will help to explain why chordates have certain aspects of their body plan and development, and by difference, what additions and modifications have been made only within the chordate line. ..
  85. REGULATION OF CARDIAC MYOGENESIS
    PARKER ANTIN; Fiscal Year: 1999
    ..This information will increase our understanding of both normal and abnormal heart development and may suggest ways to alter heart development or replication of cardiac myocytes. ..
  86. Cell Cycle Regulation by Checkpoints in Drosophila
    Tin Tin Su; Fiscal Year: 2004
    ..Aim 4) We will screen through existing mutagensensitive Drosophila mutants for their ability to regulate mitosis, S phase and cell death after irradiation, in order to uncover novel genes needed for proper response to DNA damage. ..
  87. Analysis of endocytosis in Caenorhabditis elegans
    Hanna Fares; Fiscal Year: 2003
    ..New genes identified in worms will also be studied in humans through collaborations with researchers who study this process. ..
  88. Analysis of endocytosis in Caenorhabditis elegans
    Hanna Fares; Fiscal Year: 2004
    ..New genes identified in worms will also be studied in humans through collaborations with researchers who study this process. ..
  89. Cell Cycle Regulation by Checkpoints in Drosophila
    Tin Tin Su; Fiscal Year: 2003
    ..Aim 4) We will screen through existing mutagensensitive Drosophila mutants for their ability to regulate mitosis, S phase and cell death after irradiation, in order to uncover novel genes needed for proper response to DNA damage. ..
  90. Cell Cycle Regulation by Checkpoints in Drosophila
    Tin Tin Su; Fiscal Year: 2002
    ..Aim 4) We will screen through existing mutagensensitive Drosophila mutants for their ability to regulate mitosis, S phase and cell death after irradiation, in order to uncover novel genes needed for proper response to DNA damage. ..
  91. REGULATION OF CARDIAC MYOGENESIS
    PARKER ANTIN; Fiscal Year: 2000
    ..This information will increase our understanding of both normal and abnormal heart development and may suggest ways to alter heart development or replication of cardiac myocytes. ..
  92. GEISHA, a Chicken Embryo Gene Expression Resource
    PARKER ANTIN; Fiscal Year: 2005
    ..This centralized repository for in situ hybridization gene expression information will provide a valuable and comprehensive resource for the biomedical research community. ..
  93. Analysis of endocytosis in Caenorhabditis elegans
    Hanna Fares; Fiscal Year: 2005
    ..New genes identified in worms will also be studied in humans through collaborations with researchers who study this process. ..
  94. Cell Cycle Regulation by Checkpoints in Drosophila
    Tin Tin Su; Fiscal Year: 2002
    ..Aim 4) We will screen through existing mutagensensitive Drosophila mutants for their ability to regulate mitosis, S phase and cell death after irradiation, in order to uncover novel genes needed for proper response to DNA damage. ..