Genomes and Genes
Summary: The embryo of species other than mammals. For the chicken, use the specific CHICK EMBRYO.
Publications241 found, 100 shown here
- High-resolution in situ hybridization to whole-mount zebrafish embryosChristine Thisse
Department of Cell Biology, University of Virginia Health Sciences Center, PO Box 800732, 1300 Jefferson Park Avenue, Charlottesville, Virginia 22908, USA
Nat Protoc 3:59-69. 2008..The whole procedure takes only 3 days and, because ISH conditions are the same for each probe tested, allows high throughput analysis of zebrafish gene expression during embryogenesis...
- Controlling morpholino experiments: don't stop making antisenseJudith S Eisen
Institute of Neuroscience, 1254 University of Oregon, Eugene, OR 97403 1254, USA
Development 135:1735-43. 2008..We also discuss how the use of morpholinos can lead to misleading results, including off-target effects, and we suggest controls that will allow researchers to interpret morpholino experiments correctly...
- RNA polymerase stalling at developmental control genes in the Drosophila melanogaster embryoJulia Zeitlinger
Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, Massachusetts 02142, USA
Nat Genet 39:1512-6. 2007..We propose that Pol II stalling facilitates rapid temporal and spatial changes in gene activity during development...
- Drosophila melanogaster embryonic haemocytes: masters of multitaskingWill Wood
Department of Biology and Biochemistry, University of Bath, BA2 7AY, UK
Nat Rev Mol Cell Biol 8:542-51. 2007..Instead, throughout development, embryonic haemocytes are occupied with other tasks: they undergo complex migrations and carry out several non-immune functions that are crucial for successful embryogenesis...
- sonic hedgehog and vascular endothelial growth factor act upstream of the Notch pathway during arterial endothelial differentiationNathan D Lawson
Laboratory of Molecular Genetics, NICHD, NIH, Bethesda, MD 20892, USA
Dev Cell 3:127-36. 2002..These studies reveal a complex signaling cascade responsible for establishing arterial cell fate and suggest differential effects of Vegf on developing endothelial cells...
- Multiple forces contribute to cell sheet morphogenesis for dorsal closure in DrosophilaD P Kiehart
Department of Cell Biology, Cell and Molecular Biology Program, University Program in Genetics and the Duke Comprehensive Cancer Center, Duke University Medical Center, Durham, North Carolina 27710 3709, USA
J Cell Biol 149:471-90. 2000..Moreover, our observations demonstrate that wound healing in this insect epidermal system parallel wound healing in vertebrate tissues in situ and vertebrate cells in culture (for review see Kiehart, D.P. 1999. Curr. Biol. 9:R602-R605)...
- Mechanisms of asymmetric cell division: flies and worms pave the wayPIERRE GONCZY
Swiss Institute for Experimental Cancer Research ISREC, Swiss Federal Institute of Technology EPFL, School of Life Sciences, Lausanne, Switzerland
Nat Rev Mol Cell Biol 9:355-66. 2008..Lessons learned from these two model organisms also apply to cells that divide asymmetrically in other metazoans, such as self-renewing stem cells in mammals...
- Distinct mechanisms regulate hemocyte chemotaxis during development and wound healing in Drosophila melanogasterWill Wood
Instituto Gulbenkian de Ciencia, 2780 156 Oeiras, Portugal
J Cell Biol 173:405-16. 2006....
- Fgf10 regulates hepatopancreatic ductal system patterning and differentiationP Duc Si Dong
Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics and Human Genetics, and the Diabetes Center, University of California, San Francisco, 1550 Fourth Street, San Francisco, California 94158, USA
Nat Genet 39:397-402. 2007..These data shed light onto how the multipotent cells of the foregut endoderm, and subsequently those of the hepatopancreatic duct, are directed toward different organ fates...
- Control of chemokine-guided cell migration by ligand sequestrationBijan Boldajipour
Center for Molecular Biology of Inflammation, Von Esmarch Strasse 56, D 48149 Munster, Germany
Cell 132:463-73. 2008....
- Multicellular rosette formation links planar cell polarity to tissue morphogenesisJ Todd Blankenship
Developmental Biology Program, Sloan Kettering Institute, New York, New York 10021, USA
Dev Cell 11:459-70. 2006..We propose that the generation of higher-order rosette structures links local cell interactions to global tissue reorganization during morphogenesis...
- Silencing of Smed-betacatenin1 generates radial-like hypercephalized planariansMarta Iglesias
Departament de Genetica, Universitat de Barcelona, 08028 Barcelona, Spain
Development 135:1215-21. 2008..mediterranea beta-catenins could be functionally specialized and that only Smed-betacatenin1 is involved in Wnt signalling...
- Quantitative transcript imaging in normal and heat-shocked Drosophila embryos by using high-density oligonucleotide arraysR Leemans
Institute of Zoology, Biocenter Pharmacenter, University of Basel, CH 4056 Basel, Switzerland
Proc Natl Acad Sci U S A 97:12138-43. 2000..These results demonstrate that high-density oligonucleotide arrays are sensitive, efficient, and quantitative instruments for the analysis of large scale gene expression in Drosophila embryos...
- Formation of the bicoid morphogen gradient: an mRNA gradient dictates the protein gradientAlexander Spirov
Center for Developmental Genetics, Stony Brook University, Stony Brook, NY 11794 5140, USA
Development 136:605-14. 2009....
- Dynamic analysis of filopodial interactions during the zippering phase of Drosophila dorsal closureThomas H Millard
Department of Biochemistry, School of Medical Sciences, University of Bristol, University Walk, Bristol BS8 1DA, UK
Development 135:621-6. 2008..Finally, we characterise the behaviour of a patched-expressing cell that we observe within the engrailed region of segments A1-A5, and provide evidence that this cell contributes to cell matching...
- Dishevelled controls apical docking and planar polarization of basal bodies in ciliated epithelial cellsTae Joo Park
Department of Molecular Cell and Developmental Biology and Institute for Cellular and Molecular Biology, University of Texas, Austin, Texas 78712, USA
Nat Genet 40:871-9. 2008..These results demonstrate previously undescribed functions for PCP signaling components and suggest that a common signaling apparatus governs both apical docking and planar polarization of basal bodies...
- p53-dependent neuronal cell death in a DJ-1-deficient zebrafish model of Parkinson's diseaseSandrine Bretaud
Centre for Developmental and Biomedical Genetics, University of Sheffield, Sheffield, UK
J Neurochem 100:1626-35. 2007..Our study demonstrates the utility of zebrafish as a new animal model to study PD gene defects and suggests that modulation of downstream mechanisms, such as p53 inhibition, may be of therapeutic benefit...
- SegmentationDiethard Tautz
Institut für Genetik der Universität zu Köln, Weyertal 121, 50931, Germany
Dev Cell 7:301-12. 2004..An old concept of comparative anatomy, the enterocoele theory, is compatible with a single origin of segmentation mechanisms and could therefore provide a conceptual framework for assessing these molecular similarities...
- Cranio-lenticulo-sutural dysplasia is caused by a SEC23A mutation leading to abnormal endoplasmic-reticulum-to-Golgi traffickingSimeon A Boyadjiev
McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Nat Genet 38:1192-7. 2006..Our observations suggest that disrupted endoplasmic reticulum export of the secretory proteins required for normal morphogenesis accounts for CLSD...
- Regulation of cytokinesis by Rho GTPase fluxAnn L Miller
Department of Zoology, University of Wisconsin Madison, Madison, WI 53706, USA
Nat Cell Biol 11:71-7. 2009....
- rst and its paralogue kirre act redundantly during embryonic muscle development in DrosophilaM Strünkelnberg
Institut fur Biologie III, Schänzlestr 1, Albert Ludwigs Universitat, D 79104 Freiburg im Breisgau, Germany
Development 128:4229-39. 2001..This defect can be rescued by one copy of either gene. Moreover, Rst, like Kirre is a myoblast attractant...
- Activation of transcription in Drosophila embryos is a gradual process mediated by the nucleocytoplasmic ratioD K Pritchard
Department of Genetics, University of Washington, Seattle, Washington, USA
Genes Dev 10:1131-42. 1996....
- Gateway compatible vectors for analysis of gene function in the zebrafishJacques A Villefranc
Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
Dev Dyn 236:3077-87. 2007..Taken together, this work provides an important platform for the rapid functional analyses of open reading frames in zebrafish embryos...
- Whole-genome ChIP-chip analysis of Dorsal, Twist, and Snail suggests integration of diverse patterning processes in the Drosophila embryoJulia Zeitlinger
Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, Massachusetts 02142, USA
Genes Dev 21:385-90. 2007..Thus, the ChIP-chip data uncover a much larger than expected regulatory network, which integrates diverse patterning processes during development...
- RISC assembly defects in the Drosophila RNAi mutant armitageYukihide Tomari
Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA
Cell 116:831-41. 2004..Our results suggest that armi is required for RISC maturation...
- Unexpected novel relational links uncovered by extensive developmental profiling of nuclear receptor expressionStephanie Bertrand
Molecular Zoology, Institut de Génomique Fonctionelle de Lyon UMR 5242 du CNRS, INRA, IFR128 Biosciences Lyon Gerland, Universite de Lyon, UCB Ecole Normale Supérieure de Lyon, France
PLoS Genet 3:e188. 2007..Altogether, this expression database of NRs provides novel routes for leading investigation into the biological function of each individual NR as well as for the study of their combinatorial regulatory circuitry within the superfamily...
- Cooperation of polarized cell intercalations drives convergence and extension of presomitic mesoderm during zebrafish gastrulationChunyue Yin
Department of Biological Sciences, Vanderbilt University, Nashville, TN 37235, USA
J Cell Biol 180:221-32. 2008....
- Indirect effects of ploidy suggest X chromosome dose, not the X:A ratio, signals sex in DrosophilaJames W Erickson
Department of Biology, Texas A and M University, College Station, Texas, United States of America
PLoS Biol 5:e332. 2007..Our findings reiterate that correlations between X:A ratios and cell fates in other organisms need not implicate the value of the ratio as an active signal...
- Fluorescent in situ hybridization protocols in Drosophila embryos and tissuesEric Lecuyer
Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada
Methods Mol Biol 420:289-302. 2008..We also describe variations of the method for RNA-RNA and RNA-protein codetection...
- Shaping a morphogen gradient for positional precisionFeng He
Division of Biomedical Informatics, Cincinnati Children s Hospital Research Foundation, Cincinnati, Ohio, USA
Biophys J 99:697-707. 2010..Our results demonstrate that the positional information provided by the wt Bcd gradient profile is highly precise and necessary for patterning precision...
- Effects of RAS on the genesis of embryonal rhabdomyosarcomaDavid M Langenau
Stem Cell Program and Division of Hematology, Children s Hospital Boston and Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
Genes Dev 21:1382-95. 2007..When coupled with gene expression studies of this cell population, we propose that the zebrafish RMS cancer stem cell shares similar self-renewal programs as those found in activated satellite cells...
- Induction of the Xenopus organizer: expression and regulation of Xnot, a novel FGF and activin-regulated homeo box geneG von Dassow
Department of Biochemistry, University of Washington, Seattle 98195
Genes Dev 7:355-66. 1993..Our results provide experimental evidence supporting the proposed division of Spemann's organizer into independently regulated organizing centers...
- An epidermal barrier wound repair pathway in Drosophila is mediated by grainy headKimberly A Mace
Section of Cell and Developmental Biology, Division of Biology, University of California, San Diego, La Jolla, CA 92093, USA
Science 308:381-5. 2005..The conservation of this Grh-dependent pathway suggests that the repair of insect cuticle and mammal skin is controlled by an ancient, shared control system for constructing and healing the animal body surface barrier...
- Epigenetic memory of an active gene state depends on histone H3.3 incorporation into chromatin in the absence of transcriptionRay Kit Ng
Wellcome Trust Cancer Research UK Gurdon Institute, Tennis Court Road, Cambridge CB2 1QN, UK
Nat Cell Biol 10:102-9. 2008..Hence, we suggest that epigenetic memory helps to stabilize gene expression in normal development; it might also help to account for the inefficient reprogramming in some transplanted nuclei...
- Inhibition of Müller glial cell division blocks regeneration of the light-damaged zebrafish retinaRyan Thummel
Department of Biological Sciences and the Center for Zebrafish Research, University of Notre Dame, Notre Dame, Indiana 46556, USA
Dev Neurobiol 68:392-408. 2008....
- 2,3,7,8-Tetrachlorodibenzo-p-dioxin activation of the aryl hydrocarbon receptor/aryl hydrocarbon receptor nuclear translocator pathway causes developmental toxicity through a CYP1A-independent mechanism in zebrafishSara A Carney
Molecular and Environmental Toxicology Center, University of Wisconsin, 777 Highland Avenue, Madison, WI 53705, USA
Mol Pharmacol 66:512-21. 2004..This suggests an alternative model in which TCDD-activated AHR/ARNT disrupts the normal process of growth and development by altering programs of gene expression or function...
- Dnmt2 functions in the cytoplasm to promote liver, brain, and retina development in zebrafishKunal Rai
Howard Hughes Medical Institute, University of Utah, Salt Lake City, Utah 84112, USA
Genes Dev 21:261-6. 2007..Furthermore, zebrafish Dnmt2 methylates an RNA species of approximately 80 bases, consistent with tRNA methylation. Thus, Dnmt2 promotes zebrafish development, likely through cytoplasmic RNA methylation...
- Transgenesis and gene trap methods in zebrafish by using the Tol2 transposable elementKoichi Kawakami
Division of Molecular and Developmental Biology, National Institute of Genetics, Mishima, Shizuoka 411-8540, Japan
Methods Cell Biol 77:201-22. 2004
- Revisiting the role of the mother centriole in centriole biogenesisA Rodrigues-Martins
Instituto Gulbenkian de Ciencia, Cell Cycle Regulation Laboratory, Rua da Quinta Grande, 6, P 2780 156 Oeiras, Portugal
Science 316:1046-50. 2007..The mother centriole is not a bona fide template but a platform for a set of regulatory molecules that catalyzes and regulates daughter centriole assembly...
- Identification and real-time imaging of a myc-expressing neutrophil population involved in inflammation and mycobacterial granuloma formation in zebrafishAnnemarie H Meijer
Institute of Biology, Leiden University, Wassenaarseweg 64, 2333 AL Leiden, The Netherlands
Dev Comp Immunol 32:36-49. 2008..Using real-time confocal imaging we demonstrate that these cells migrate to sites of inflammation and are involved in innate immune responses towards infections, including Mycobacterium marinum-induced granuloma formation...
- Dishevelled: a mobile scaffold catalyzing developmentCraig C Malbon
Department of Pharmacology, State University of New York at Stony Brook, Stony Brook, New York 11794, USA
Curr Top Dev Biol 72:153-66. 2006..Much excitement awaits the elucidation of the complete set of tools in the toolbox and of the dynamic regulation of Dishevelled proteins and their interacting proteins...
- Aryl hydrocarbon receptor 2 mediates 2,3,7,8-tetrachlorodibenzo-p-dioxin developmental toxicity in zebrafishAmy L Prasch
Molecular and Environmental Toxicology Center, University of Wisconsin, Madison, Wisconsin 53726, USA
Toxicol Sci 76:138-50. 2003..Most strikingly, zfahr2 morphants exposed to TCDD never developed edema. Taken together, these results demonstrate that zfAHR2 mediates several endpoints of TCDD developmental toxicity in zebrafish...
- Size control: cell proliferation does not equal growthT T Su
Department of Biochemistry and Biophysics, University of California San Francisco 94143 0448, USA
Curr Biol 8:R687-9. 1998..Both classic and recent experiments confirm this simple rationale: altering proliferation produces normally sized body structures with either especially small or exceptionally large cells...
- Origin and shaping of the laterality organ in zebrafishPablo Oteiza
Laboratory of Experimental Ontogeny, Program of Anatomy and Developmental Biology, Institute of Biomedical Sciences, University of Chile, Clasificador 7 Correo 7, Santiago, Chile
Development 135:2807-13. 2008..Our results provide novel insights into the morphogenetic transformations that shape the laterality organ in zebrafish and suggest a conserved progenitor role of the surface epithelium during laterality organ formation in vertebrates...
- Glycogen synthase kinase-3 and dorsoventral patterning in Xenopus embryosX He
Varmus Laboratory, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Nature 374:617-22. 1995..These results indicate that GSK-3 is required for ventral differentiation, and suggest that dorsal differentiation may involve the suppression of GSK-3 activity by a wingless/wnt-related signal...
- The polo-like kinase PLK-1 is required for nuclear envelope breakdown and the completion of meiosis in Caenorhabditis elegansD Chase
National Institute on Aging, National Cancer Institute FCRF, Frederick, Maryland 21702, USA
Genesis 26:26-41. 2000..These defects led to embryonic arrest as single cells. genesis 26:26-41, 2000. Published 2000 Wiley-Liss, Inc...
- The Drosophila patched gene encodes a putative membrane protein required for segmental patterningJ E Hooper
Howard Hughes Medical Institute, University of Colorado, Boulder 80309 0347
Cell 59:751-65. 1989..The pattern of expression does not directly predict the transformation seen in ptc mutant embryos, suggesting that ptc participates in cell interactions that establish pattern within the segment...
- Haemocyte-derived SPARC is required for collagen-IV-dependent stability of basal laminae in Drosophila embryosNathalie Martinek
Department of Cell and Systems Biology, University of Toronto, 25 Harbord Street, Toronto, Ontario, M5S 3G5, Canada
J Cell Sci 121:1671-80. 2008..Hence, SPARC is required for basal lamina maturation and condensation of the ventral nerve cord during Drosophila embryogenesis...
- Dynamic changes in the distribution of cytoplasmic myosin during Drosophila embryogenesisP E Young
Department of Cellular and Developmental Biology, Harvard University, Cambridge, MA 02138
Development 111:1-14. 1991....
- Organization and function of the blood-brain barrier in DrosophilaTobias Stork
Institut fur Neurobiologie, Universitat Munster, D 48149 Münster Germany
J Neurosci 28:587-97. 2008....
- Foxn4 directly regulates tbx2b expression and atrioventricular canal formationNeil C Chi
Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics and Human Genetics, University of California, San Francisco, San Francisco, California 94158, USA
Genes Dev 22:734-9. 2008..sli/foxn4 is expressed in the AV canal, and its encoded product binds to a highly conserved tbx2 enhancer domain that contains Foxn4- and T-box-binding sites, both necessary to regulate tbx2b expression in the AV canal...
- Normal table of postembryonic zebrafish development: staging by externally visible anatomy of the living fishDavid M Parichy
Department of Biology, University of Washington, Seattle, Washington 91895, USA
Dev Dyn 238:2975-3015. 2009..Finally, we provide guidelines for reporting stages that provide information on both discrete and continuous changes in growth and development...
- dlx3b/4b are required for the formation of the preplacodal region and otic placode through local modulation of BMP activityRobert Esterberg
Department of Biology, Emory University, Atlanta, GA 30322, USA
Dev Biol 325:189-99. 2009..Our results provide insight into the mechanisms of PPR specification as well as the role of dlx3b/4b function in PPR and otic placode induction...
- Paternal chromosome segregation during the first mitotic division determines Wolbachia-induced cytoplasmic incompatibility phenotypeUyen Tram
University of California, Santa Cruz, Molecular, Cellular, and Developmental Biology, 319 Sinsheimer Laboratories, Santa Cruz, CA 95064, USA
J Cell Sci 119:3655-63. 2006..This is the first study to associate differences in types of CI with specific cytological defects...
- The basic-helix-loop-helix domain of Drosophila lethal of scute protein is sufficient for proneural function and activates neurogenic genesU Hinz
Institut fur Entwicklungsbiologie, Universitat zu Koln, Federal Republic of Germany
Cell 76:77-87. 1994..Finally, the bHLH domain is necessary and sufficient to mediate the proneural function, to activate neurogenic genes, and to allow lateral inhibition...
- Skin development in bony fish with particular emphasis on collagen deposition in the dermis of the zebrafish (Danio rerio)Dominique Le Guellec
Institut de Biologie et Chimie des Proteines, Lyon, France
Int J Dev Biol 48:217-31. 2004..This suggests that the fibroblasts secrete a still unidentified signalling molecule that downregulates collagen production by the epidermis...
- Soma-germline asymmetry in the distributions of embryonic RNAs in Caenorhabditis elegansG Seydoux
Carnegie Institution of Washington, Baltimore, MD 21210, USA
Development 120:2823-34. 1994..These observations suggest that mechanisms which distinguish between soma and germline cause asymmetries in mRNA stability and transcription within the first few cleavages of C. elegans embryogenesis...
- Abdominal segmentation, pole cell formation, and embryonic polarity require the localized activity of oskar, a maternal gene in DrosophilaR Lehmann
Cell 47:141-52. 1986..The participation of the osk product in the establishment of a source of morphogenetic activity in the posterior pole plasm is discussed...
- Regulation of cell number by MAPK-dependent control of apoptosis: a mechanism for trophic survival signalingAndreas Bergmann
Department of Biology, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Dev Cell 2:159-70. 2002..Therefore, a direct pathway linking a specific extracellular survival factor with a caspase-based death program has been established...
- Live imaging of wound inflammation in Drosophila embryos reveals key roles for small GTPases during in vivo cell migrationBrian Stramer
Department of Physiology, School of Medical Sciences, University of Bristol, Bristol, BS8 1TD, UK
J Cell Biol 168:567-73. 2005..Cdc42 is necessary for maintaining cellular polarity and yet, despite in vitro evidence, is dispensable for sensing and crawling toward wound cues...
- Zebrafish early cardiac connexin, Cx36.7/Ecx, regulates myofibril orientation and heart morphogenesis by establishing Nkx2.5 expressionNaznin Sultana
Departments of Biological Sciences and Biological Information, Tokyo Institute of Technology, Yokohama 226 8501, Japan
Proc Natl Acad Sci U S A 105:4763-8. 2008..5 expression, which in turn promotes unidirectional, parallel alignment of myofibrils and the subsequent proper heart morphogenesis...
- DmPAR-6 directs epithelial polarity and asymmetric cell division of neuroblasts in DrosophilaM Petronczki
Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
Nat Cell Biol 3:43-9. 2001....
- Pre-steady-state decoding of the Bicoid morphogen gradientSven Bergmann
Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
PLoS Biol 5:e46. 2007..This can explain the surprisingly small shifts in gap and pair-rule gene expression domains observed in response to alterations in bcd dosage...
- Patterning the zebrafish diencephalon by the conserved zinc-finger protein FezlJae Yeon Jeong
Program in Developmental Biology, Department of Biopharmaceutical Sciences, University of California San Francisco, CA 94143 2811, USA
Development 134:127-36. 2007..Our findings reveal that Fezl is crucial for establishing regional subdivisions within the diencephalon and may also play a role in the development of the telencephalon and hypothalamus...
- Synchrony dynamics during initiation, failure, and rescue of the segmentation clockIngmar H Riedel-Kruse
Max Planck Institute of Molecular Cell Biology and Genetics MPI CBG, Pfotenhauerstrasse 108, 01307 Dresden, Germany
Science 317:1911-5. 2007..We conclude that synchrony among these genetic oscillators can be established by simultaneous initiation and self-organization and that the segmentation defect position is determined by the difference between coupling strength and noise...
- Haploinsufficiency of Six3 fails to activate Sonic hedgehog expression in the ventral forebrain and causes holoprosencephalyXin Geng
Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
Dev Cell 15:236-47. 2008..These results identify Six3 as a direct regulator of Shh expression and reveal a crossregulatory loop between Shh and Six3 in the ventral forebrain...
- Genetic analysis of the two zebrafish patched homologues identifies novel roles for the hedgehog signaling pathwayMarco J Koudijs
Hubrecht Institute, Developmental Biology and Stem Cell Research, Uppsalalaan 8, 3584CT, Utrecht, The Netherlands
BMC Dev Biol 8:15. 2008..We attempted to fully activate the Hh pathway by removing both receptors for the Hh proteins, called Patched1 and 2, which are functioning as negative regulators in this pathway...
- smad2 and smad3 are required for mesendoderm induction by transforming growth factor-beta/nodal signals in zebrafishShunji Jia
Protein Science Laboratory of the Ministry of Education, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China
J Biol Chem 283:2418-26. 2008..Thus, our data reveal that Nodal signaling and mesendoderm induction depend on Smad2/3 and suggest that transforming growth factor-beta signals other than Nodal also contribute to Smad2/3 signaling and embryonic patterning...
- MicroRNA-9 directs late organizer activity of the midbrain-hindbrain boundaryChristoph Leucht
Department of Zebrafish Neurogenetics, Institute of Developmental Genetics, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Ingolstadter Landstrasse 1, D 85764 Neuherberg, Germany
Nat Neurosci 11:641-8. 2008..Together, these findings highlight a previously unknown mechanism by which a single microRNA fine-tunes late MHB coherence via its co-regulation of patterning activities and neurogenesis...
- Gfi1.1 regulates hematopoietic lineage differentiation during zebrafish embryogenesisWei Wei
Key Laboratory of Cell Proliferation and Differentiation, Center of Developmental Biology and Genetics, College of Life Sciences, Peking University, Ministry of Education, Beijing 100871, China
Cell Res 18:677-85. 2008..1 plays a critical role in regulating the balance of embryonic erythroid and myeloid lineage determination, and is also required for the differentiation of lymphocytes and granulocytes during zebrafish embryogenesis...
- Oscillators and the emergence of tissue organization during zebrafish somitogenesisAndrew Mara
Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520, USA
Trends Cell Biol 17:593-9. 2007..Here, we review recent progress in our understanding of the role of the Notch signaling pathway in the zebrafish segmentation oscillator and our appreciation of how the oscillator interfaces with different sources of noise...
- Expression pattern for unc5b, an axon guidance gene in embryonic zebrafish developmentSukhbir Kaur
Genome Technology Branch, NHGRI, National Institutes of Health, Bethesda, MD, USA
Gene Expr 13:321-7. 2007..A similar medial-lateral theme is observed in other neural structures such as the neural tube. Our expression analysis provides a starting point for studying the role of axon guidance genes in embryonic hindbrain patterning...
- FGF-dependent mechanosensory organ patterning in zebrafishAlex Nechiporuk
University of Washington, School of Medicine, Department of Biological Structure, Seattle, WA 98195 7420, USA
Science 320:1774-7. 2008..This previously unrecognized mechanism may be applicable to understanding segmentation and morphogenesis in other organ systems...
- Otx1l, Otx2 and Irx1b establish and position the ZLI in the diencephalonSteffen Scholpp
MRC Centre for Developmental Neurobiology, New Hunt s House, Guy s Campus, King s College London, London SE1 1UL, UK
Development 134:3167-76. 2007..We therefore propose that the ZLI is induced within the competence area established by Otx1l/2, and is posteriorly restricted by Irx1b...
- The Wilms tumor genes wt1a and wt1b control different steps during formation of the zebrafish pronephrosBirgit Perner
Leibniz Institute for Age Research Fritz Lipmann Institute, Beutenbergstrasse 11, 07745 Jena, Germany
Dev Biol 309:87-96. 2007..While wt1a has a more fundamental and early role in pronephros development and is essential for the formation of glomerular structures, wt1b functions at later stages of nephrogenesis...
- Gene regulation: boundaries within limitsSandhya Payankaulam
Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan 48824 1319, USA
Curr Biol 18:R653-R655. 2008....
- Extracellular modulation of BMP activity in patterning the dorsoventral axisShawn C Little
Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-6058, USA
Birth Defects Res C Embryo Today 78:224-42. 2006..This review examines recent developments in the field of DV patterning by BMP signaling, focusing on extracellular modulation as a key mechanism in the formation of BMP signaling gradients in Drosophila, Xenopus, and zebrafish...
- Cleavage of the BMP-4 antagonist chordin by zebrafish tolloidP Blader
Institut de Genetique et de Biologie Moleculaire et Cellulaire IGBMC, CNRS INSERM ULP, BP 163, 67404 Illkirch Cedex, C U de Strasbourg, France
Science 278:1937-40. 1997..These data suggest that Tolloid antagonizes Chordin activity by proteolytically cleaving Chordin. A conserved function for zebrafish and Drosophila Tolloid during embryogenesis is proposed...
- Zebrafish nma is involved in TGFbeta family signalingM Tsang
Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, Bethesda, Maryland 20892, USA
Genesis 28:47-57. 2000..We propose that nma is a BMP-regulated gene whose function is to attenuate BMP signaling during development through interactions with type II receptors and ligands...
- Developmental biology. Fishing for morphogensS Vincent
Nature 411:533, 535-6. 2001
- The planar cell-polarity gene stbm regulates cell behaviour and cell fate in vertebrate embryosMaiyon Park
Howard Hughes Medical Institute, Department of Pharmacology and Center for Developmental Biology, University of Washington School of Medicine, Seattle, Washington 98195, USA
Nat Cell Biol 4:20-5. 2002....
- Heads or tails? Amphioxus and the evolution of anterior-posterior patterning in deuterostomesLinda Z Holland
Marine Biology Research Division, Scripps Institution of Oceanography, University of California San Diego, La Jolla, CA 92093 0202, USA
Dev Biol 241:209-28. 2002..Thus, roles for Wnt-signaling in dorso-ventral patterning of embryos may be a vertebrate innovation that arose in connection with the evolution of yolky eggs and gastrulation by extensive involution...
- A transgenic Lef1/beta-catenin-dependent reporter is expressed in spatially restricted domains throughout zebrafish developmentRichard I Dorsky
Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA
Dev Biol 241:229-37. 2002..We conclude that our TOP-dGFP reporter line faithfully illustrates domains of beta-catenin activity and enables the identification of responsive cell populations...
- Regulation of nodal signalling and mesendoderm formation by TARAM-A, a TGFbeta-related type I receptorTazu O Aoki
U368 INSERM, , 46 rue d'Ulm, 75230 Paris, France
Dev Biol 241:273-88. 2002..Together, our results point to Tar as an essential factor for endoderm formation and an important modulator of Nodal signalling, potentially representing one of the Nodal receptors. (c)2001 Elsevier Science...
- The planar polarity gene strabismus regulates convergent extension movements in XenopusRachel S Darken
Department of Cell Biology, Weill Medical College, New York, NY 10021, USA
EMBO J 21:976-85. 2002..Thus our results strongly support the emerging hypothesis that a vertebrate analog of the planar polarity pathway governs convergent extension movements...
- Ccd1, a novel protein with a DIX domain, is a positive regulator in the Wnt signaling during zebrafish neural patterningKensuke Shiomi
Department of Molecular Neurobiology, Institute of Basic Medical Sciences, University of Tsukuba, 1 1 1 Tennoudai, 305 8575, Tsukuba, Ibaraki, Japan
Curr Biol 13:73-7. 2003..These results indicate that Ccd1 is a novel positive regulator in this Wnt signaling pathway during zebrafish neural patterning...
- Temporal and cellular requirements for Fms signaling during zebrafish adult pigment pattern developmentDavid M Parichy
Section of Integrative Biology, Section of Molecular, Cell and Developmental Biology, Institute for Cellular and Molecular Biology, University of Texas at Austin, 1 University Station C0930, Austin, TX 78712, USA
Development 130:817-33. 2003....
- Maternally controlled (beta)-catenin-mediated signaling is required for organizer formation in the zebrafishC Kelly
Department of Biology, The University of Pennsylvania, Philadelphia, PA 19104, USA
Development 127:3899-911. 2000..This work demonstrates that a maternal gene controlling localization of (beta)-catenin in dorsal nuclei is necessary for dorsal yolk syncytial layer gene activity and formation of the organizer in the zebrafish...
- Cloning and characterization of zebrafish smad2, smad3 and smad4A Dick
Max Planck Institut fur Immunbiologie, Stubeweg 51, D 79108, Freiburg, Germany
Gene 246:69-80. 2000..These data suggest that Smad2 acts as a mediator of Nodal signals during zebrafish midline signaling, while Smad3 might be involved in later steps of eye field separation...
- The lefty-related factor Xatv acts as a feedback inhibitor of nodal signaling in mesoderm induction and L-R axis development in xenopusA M Cheng
Dept Cell Biology, Vanderbilt University School of Medicine, Nashville, TN 37232 2175, USA
Development 127:1049-61. 2000..We propose that the induction of lefty/Xatv in the left LPM by nodal/Xnr1 provides an efficient self-regulating mechanism to downregulate nodal/Xnr1 expression and ensure a transient 'left' signal within the embryo...
- Fish are like flies are like frogs: conservation of dorsal-ventral patterning mechanismsS A Holley
Department of Molecular Genetics and Cell Biology, University of Chicago, IL 60637, USA
Bioessays 19:281-4. 1997..Characterization of these mutations parallels findings from Drosophila, thus establishing a genetic framework for the analysis of dorsal-ventral patterning in a vertebrate...
- Mindin/F-spondin family: novel ECM proteins expressed in the zebrafish embryonic axisS Higashijima
National Institute for Basic Biology, Aichi, Japan
Dev Biol 192:211-27. 1997..In summary, our study has defined a novel gene family of ECM molecules in the vertebrate, all of which may potentially be involved in development of the midline structure...
- Differential regulation of chordin expression domains in mutant zebrafishV E Miller-Bertoglio
Department of Embryology, Carnegie Institution of Washington, Baltimore, Maryland 21210, USA
Dev Biol 192:537-50. 1997..1989), while axial mesodermal expression was affected. This finding reveals an unexpected function for spadetail in midline mesoderm and in differential regulation of chordin expression during gastrulation...
- In vivo analyses of cytoplasmic transport and cytoskeletal organization during Drosophila oogenesis: characterization of a multi-step anterior localization pathwayW E Theurkauf
Department of Biochemistry and Cell Biology and the Institute for Cell and Developmental Biology, State University of New York at Stony Brook, Stony Brook, NY 11794 5215, USA
Development 125:3655-66. 1998..Based on these observations, we propose a multi-step anterior localization pathway...
- Role of Nudel protease activation in triggering dorsoventral polarization of the Drosophila embryoE K LeMosy
Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06520 8002, USA
Development 125:4045-53. 1998....
- Antivin, a novel and divergent member of the TGFbeta superfamily, negatively regulates mesoderm inductionC Thisse
Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, BP 163, CU de Strasbourg, France u strasbg fr
Development 126:229-40. 1999..On the basis of its expression and activity, we propose that Antivin normally functions as a competitive inhibitor of Activin to limit mesoderm induction in the early embryo...
- her4, a zebrafish homologue of the Drosophila neurogenic gene E(spl), is a target of NOTCH signallingC Takke
Institut fur Entwicklungsbiologie, Universitat zu Koln, Germany
Development 126:1811-21. 1999..These results suggest that her4 acts as a target of notch-mediated signals that regulate primary neurogenesis...
- Three different noggin genes antagonize the activity of bone morphogenetic proteins in the zebrafish embryoM Fürthauer
Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS, INSERM, ULP, 1 rue Laurent Fries, Illkirch Cedex, 67404, France
Dev Biol 214:181-96. 1999..Finally we show that noggin1 is expressed in the fish organizer and able to dorsalize the embryo, suggesting its implication in the dorsoventral patterning of the zebrafish...
- Gata5 is required for the development of the heart and endoderm in zebrafishJ F Reiter
Department of Biochemistry and Biophysics, Programs in Human Genetics and Developmental Biology, University of California at San Francisco, San Francisco, California 94143 0448 USA
Genes Dev 13:2983-95. 1999..Together, these results implicate zebrafish Gata5 in controlling the growth, morphogenesis, and differentiation of the heart and endoderm and indicate that Gata5 regulates the expression of the early myocardial gene nkx2.5...
- Fibronectin regulates epithelial organization during myocardial migration in zebrafishL A Trinh
Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics and Human Genetics, University of California, San Francisco, San Francisco, CA 94143, USA
Dev Cell 6:371-82. 2004..These data suggest that myocardial migration is dependent on epithelial integrity...
- Nodal and BMP2/4 signaling organizes the oral-aboral axis of the sea urchin embryoVeronique Duboc
UMR 7009 Centre National de la Recherche Scientifique, Universite Pierre et Marie Curie, Observatoire Oceanologique, 06230 Villefranche sur Mer, France
Dev Cell 6:397-410. 2004..These observations suggest that the mechanisms responsible for patterning the oral-aboral axis of the sea urchin embryo may share similarities with mechanisms that pattern the dorsoventral axis of other deuterostomes...
Research Grants166 found, 100 shown here
- TGF-beta and axis formation in Helobdella, a lophotrochozoanDAVID WEISBLAT; Fiscal Year: 2007..They will also contribute to understanding the cellular processes known as epithelial-to-mesenchymal transitions (EMTs), which play a critical role both in normal development and in cancer metastasis. ..
- ANALYSIS OF PAIR OF RULE GENES IN SEQUENTIAL SEGMENTATIODAVID WEISBLAT; Fiscal Year: 2003..abstract_text> ..
- TGF-beta and axis formation in Helobdella, a lophotrochozoanDavid A Weisblat; Fiscal Year: 2010..They will also contribute to understanding the cellular processes known as epithelial-to-mesenchymal transitions (EMTs), which play a critical role both in normal development and in cancer metastasis. ..
- Spiralian developmental system for the study of multipotencyCesar Arenas Mena; Fiscal Year: 2007..The first objective is to identify the effector genes that set the peculiar transcriptional state of multipotency. The ultimate goal is to manipulate these genes and reprogram in vivo differentiated cells into multipotent stem cells. ..
- Cadherin6 and -10 Function in Retinal Ganglion and Amacrine Cell DevelopmentQin Liu; Fiscal Year: 2007....
- Control of Cell Proliferation by Runx ProteinsJAMES COFFMAN; Fiscal Year: 2009..purpuratus genome sequence, which will greatly facilitate both the cis-regulatory analysis of genes and the identification of purified proteins by mass spectrometry. ..
- Control of Cell Proliferation by Runx ProteinsJAMES COFFMAN; Fiscal Year: 2007..purpuratus genome sequence, which will greatly facilitate both the cis-regulatory analysis of genes and the identification of purified proteins by mass spectrometry. ..
- Regulation of Epidermal Junctions in C. elegansJEFFREY HARDIN; Fiscal Year: 2005..Moreover, this freely available, open-source suite will allow investigators and educators easy and inexpensive access to 4D analysis and acquisition capabilities using easily extensible, platform-independent Java technologies. ..
- Regulation of Epidermal Junctions in C. elegansJEFFREY HARDIN; Fiscal Year: 2007..Because these studies will be carried out in a living organism, we will gain fundamental new insights into how these key junctional complexes regulate a fundamental morphogenetic event. ..
- Redox-sensitive developmental pathways and gene regulatory networksJAMES COFFMAN; Fiscal Year: 2007..Finally, the Comparative Toxicogenomics Database (CTD) at MDIBL will be used to determine the relevance of the pathways discovered in sea urchins to human health, and to generate hypotheses that might explain specific human diseases. ..
- CONTROL OF EPITHELIAL SHEET MOVEMENT IN C ELEGANSJEFFREY HARDIN; Fiscal Year: 2003..As a result of these studies, we expect to gain a greater understanding of how specific lesions in identified molecules give rise to specific cellular defects during epithelial morphogenesis. ..
- Redox-sensitive developmental pathways and gene regulatory networksJAMES COFFMAN; Fiscal Year: 2009..Finally, the Comparative Toxicogenomics Database (CTD) at MDIBL will be used to determine the relevance of the pathways discovered in sea urchins to human health, and to generate hypotheses that might explain specific human diseases. ..
- Mechanisms of Junctional Actin Recruitment in C. elegansJEFFREY HARDIN; Fiscal Year: 2009..By studying how this protein works in living embryos, we will gain important information that can be used to understand and treat human disease. ..
- The Molecular Basis of Serpin Function and DisfunctionPatrick L Wintrode; Fiscal Year: 2010..Polymerization of alpha-1 antitrypsin is the underlying cause of these symptoms. Determining the structure of the polymerization prone intermediate is an important step in developing therapeutic agents. ..
- Mechanisms of Junctional Actin Recruitment in C. elegansJEFFREY D HARDIN; Fiscal Year: 2010..By studying how this protein works in living embryos, we will gain important information that can be used to understand and treat human disease. ..
- SIGNALING CASCADES AND LOOPS IN XENOPUS OOCYTESJAMES FERRELL; Fiscal Year: 2003..4. To determine whether regulated nuclear translocation contributes to the ultrasensitive response of p42 MAPK to upstream activators. ..
- Regulatory Genomics: BAC-GFP Library of Control GenesEric Davidson; Fiscal Year: 2007..Numerous letters from outside investigators attesting interest in this facility are included as an Appendix to this application. ..
- MOLECULAR AND CELLULAR BASIS OF LENS DEVELOPMENTJonathan J Henry; Fiscal Year: 2010....
- Bistability and the Mitotic TriggerJAMES FERRELL; Fiscal Year: 2009..An understanding of the process also promises to shed light on cancer and cancer chemotherapy. ..
- HOMOZYGOUS SEA URCHIN AS A POTENTIAL RESEARCH RESOURCEEric Davidson; Fiscal Year: 2003..purpuratus is a heritable trait, and carry out other investigations on genetic aspects of sex in S. purpuratus. ..
- MAP KINASE AND THE CELL CYCLEJAMES FERRELL; Fiscal Year: 2001..How does the MAPK cascade bring about Cdc2 activation? 4. How does activation of the MAPK cascade bring about G2 arrest in cycling extracts and embryos, and what is the significance of this arrest? ..
- An in vivo Screen for Radiation SensitizersTin Tin Su; Fiscal Year: 2007..Successful completion of this project would establish a novel, rapid and effective primary screen in vivo for radiosensitizers with potential therapeutic value. ..
- Predoctoral Fellowship for Minority StudentsLisa Chang; Fiscal Year: 2006..Some of these include microarray screening, DNA-binding assays, microinjection, microsurgery, in-situ hybridization, antisense and dominant negative inhibition of gene function, and transgenics. ..
- Regulation of Radiation Induced Cell Death in DrosophilaTin Tin Su; Fiscal Year: 2010..Because of excellent conservation of gene function between Drosophila and human, what we learn may allow us to maximize the efficacy of radiation therapy of human cancers. ..
- Regulation of Radiation Induced Cell Death in DrosophilaTin Tin Su; Fiscal Year: 2010..Because of excellent conservation of gene function between Drosophila and human, what we learn may allow us to maximize the efficacy of radiation therapy of human cancers. ..
- GEISHA, a Chicken Embryo Gene Expression ResourcePARKER ANTIN; Fiscal Year: 2009..This centralized repository for in situ hybridization gene expression information will provide a valuable and comprehensive resource for the biomedical research community. ..
- Cell Growth and Radiation Survival in DrosophilaTin Tin Su; Fiscal Year: 2007..Understanding radiation survival in a multicellular context could help identify potential therapies for when we do not want cells to survive irradiation, such as in the treatment of cancer. ..
- Hemichordartes and the Origin of ChordatesJohn Gerhart; Fiscal Year: 2009..siRNA interventions will be used to evaluate the role of the encoded gene products in development. ..
- Delineating the Role of FGF Signaling and Vertebrate Heart DevelopmentMICHAEL WAIKOK TSANG; Fiscal Year: 2010..Understanding how this molecule acts to increase heart tissue is an important step towards developing potential treatment for cardiac damage caused by heart disease. ..
- GEISHA, a Chicken Embryo Gene Expression ResourcePARKER ANTIN; Fiscal Year: 2007..This centralized repository for in situ hybridization gene expression information will provide a valuable and comprehensive resource for the biomedical research community. ..
- Delineating the Role of FGF Signaling and Vertebrate Heart DevelopmentMichael Tsang; Fiscal Year: 2009..Understanding how this molecule acts to increase heart tissue is an important step towards developing potential treatment for cardiac damage caused by heart disease. ..
- MicroRNA Gene Expression Mapping in Chicken EmbryosPARKER ANTIN; Fiscal Year: 2007..This new technology could fundamentally change the way in which in situ hybridization analyses are performed. ..
- Hemichordartes and the Origin of ChordatesJohn Gerhart; Fiscal Year: 2007..siRNA interventions will be used to evaluate the role of the encoded gene products in development. ..
- In Vivo Analysis of the Mechanisms of Neural Crest MigrationPaul M Kulesa; Fiscal Year: 2010....
- Cell Cycle Regulation by Checkpoints in DrosophilaTin Tin Su; Fiscal Year: 2006..Aim 4) We will screen through existing mutagensensitive Drosophila mutants for their ability to regulate mitosis, S phase and cell death after irradiation, in order to uncover novel genes needed for proper response to DNA damage. ..
- Analysis of endocytosis in Caenorhabditis elegansHanna Fares; Fiscal Year: 2006..New genes identified in worms will also be studied in humans through collaborations with researchers who study this process. ..
- Hemichordates and the Origin of ChordatesJohn Gerhart; Fiscal Year: 2004..Knowledge of hemichordates will help to explain why chordates have certain aspects of their body plan and development, and by difference, what additions and modifications have been made only within the chordate line. ..