bursa of fabricius

Summary

Summary: An epithelial outgrowth of the cloaca in birds similar to the thymus in mammals. It atrophies within 6 months after birth and remains as a fibrous remnant in adult birds. It is composed of lymphoid tissue and prior to involution, is the site of B-lymphocyte maturation.

Top Publications

  1. ncbi Antibodies, immunoglobulin genes and the bursa of Fabricius in chicken B cell development
    Michael J H Ratcliffe
    Department of Immunology, University of Toronto, 1 King s College Circle, Toronto, Ontario, Canada
    Dev Comp Immunol 30:101-18. 2006
  2. doi Proteomic analysis of the host response in the bursa of Fabricius of chickens infected with Marek's disease virus
    Zhanjun Lu
    Key Lab of Jiangsu Preventive Veterinary Medicine, College of Veterinary Medicine, Yangzhou University, Yangzhou City 225009, Jiangsu Province, China
    Virus Res 153:250-7. 2010
  3. ncbi Identification and characterization of two distinct bursal B-cell subpopulations following infectious bursal disease virus infection of White Leghorn chickens
    Daniel I Petkov
    Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA
    Avian Dis 53:347-55. 2009
  4. ncbi The decrease of relative weight, lesions, and apoptosis of bursa of fabricius induced by excess dietary selenium in chickens
    Xi Peng
    College of Veterinary Medicine, Sichuan Agricultural University, Yaan, Sichuan, China
    Biol Trace Elem Res 131:33-42. 2009
  5. pmc Cell transplantation into immunodeficient chicken embryos. Reconstituting capacity of cells from the yolk sac at different stages of development and from the liver, thymus, bursa of Fabricius, spleen and bone marrow of 15-day embryos
    J Eskola
    Immunology 32:467-74. 1977
  6. ncbi Developmentally programmed expression of AID in chicken B cells
    David R Withers
    Immunology and Pathology Division, Institute for Animal Health, Compton, Newbury, Berkshire RG20 7NN, UK
    Dev Comp Immunol 29:651-62. 2005
  7. ncbi Comparative immunopathogenesis of mild, intermediate, and virulent strains of classic infectious bursal disease virus
    Silke Rautenschlein
    Klinik fur Geflugel, Tierarztliche Hochschule Hannover, Bunteweg 17, 30559 Hannover, Germany
    Avian Dis 47:66-78. 2003
  8. pmc Role of Nr13 in regulation of programmed cell death in the bursa of Fabricius
    R M Lee
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Genes Dev 13:718-28. 1999
  9. ncbi Host responses in the bursa of Fabricius of chickens infected with virulent Marek's disease virus
    M F Abdul-Careem
    Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada
    Virology 379:256-65. 2008
  10. doi Characterization of responses elicited by Toll-like receptor agonists in cells of the bursa of Fabricius in chickens
    Michael St Paul
    Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada
    Vet Immunol Immunopathol 149:237-44. 2012

Detail Information

Publications199 found, 100 shown here

  1. ncbi Antibodies, immunoglobulin genes and the bursa of Fabricius in chicken B cell development
    Michael J H Ratcliffe
    Department of Immunology, University of Toronto, 1 King s College Circle, Toronto, Ontario, Canada
    Dev Comp Immunol 30:101-18. 2006
    The bursa of Fabricius is critical for the normal development of B lymphocytes in birds...
  2. doi Proteomic analysis of the host response in the bursa of Fabricius of chickens infected with Marek's disease virus
    Zhanjun Lu
    Key Lab of Jiangsu Preventive Veterinary Medicine, College of Veterinary Medicine, Yangzhou University, Yangzhou City 225009, Jiangsu Province, China
    Virus Res 153:250-7. 2010
    ..In this paper, we identified differentially expressed proteins in the bursa of Fabricius of chickens infected with the highly virulent MDV strain RB1B, using two-dimensional gel electrophoresis on ..
  3. ncbi Identification and characterization of two distinct bursal B-cell subpopulations following infectious bursal disease virus infection of White Leghorn chickens
    Daniel I Petkov
    Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA
    Avian Dis 53:347-55. 2009
    ..bursal disease virus (IBDV) is an immunosuppressive virus which primarily infects IgM B-cells in the bursa of Fabricius. Flow cytometric analysis was used to phenotype B-cell populations in the bursa and spleen following IBDV ..
  4. ncbi The decrease of relative weight, lesions, and apoptosis of bursa of fabricius induced by excess dietary selenium in chickens
    Xi Peng
    College of Veterinary Medicine, Sichuan Agricultural University, Yaan, Sichuan, China
    Biol Trace Elem Res 131:33-42. 2009
    ..of excess dietary sodium selenite on immune function by determining morphological changes and apoptosis of bursa of Fabricius. Three hundred 1-day-old Avian broilers were fed on a basic diet (0...
  5. pmc Cell transplantation into immunodeficient chicken embryos. Reconstituting capacity of cells from the yolk sac at different stages of development and from the liver, thymus, bursa of Fabricius, spleen and bone marrow of 15-day embryos
    J Eskola
    Immunology 32:467-74. 1977
    ..with histocompatible cells from the yolk sac at different stages of development and from the liver, thymus, bursa of Fabricius, spleen and bone marrow of 15-day-old-embryos...
  6. ncbi Developmentally programmed expression of AID in chicken B cells
    David R Withers
    Immunology and Pathology Division, Institute for Animal Health, Compton, Newbury, Berkshire RG20 7NN, UK
    Dev Comp Immunol 29:651-62. 2005
    ..Expression was also detected at earlier stages, implying either that expression of AID is not the only controlling factor for gene conversion, or that gene conversion can precede the formation of bursal follicles...
  7. ncbi Comparative immunopathogenesis of mild, intermediate, and virulent strains of classic infectious bursal disease virus
    Silke Rautenschlein
    Klinik fur Geflugel, Tierarztliche Hochschule Hannover, Bunteweg 17, 30559 Hannover, Germany
    Avian Dis 47:66-78. 2003
    ..05) and the most vigorous lesions in the bursa of Fabricius with the highest possible lesion score of 4 at 3 days PI (P < 0.05)...
  8. pmc Role of Nr13 in regulation of programmed cell death in the bursa of Fabricius
    R M Lee
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Genes Dev 13:718-28. 1999
    Apoptotic cell death is developmentally regulated in the chicken bursa of Fabricius. Although apoptosis is low in the embryonic bursa, cell death increases markedly after hatching...
  9. ncbi Host responses in the bursa of Fabricius of chickens infected with virulent Marek's disease virus
    M F Abdul-Careem
    Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada
    Virology 379:256-65. 2008
    The bursa of Fabricius serves as an important tissue in the process of Marek's disease virus (MDV) pathogenesis, since B cells of the bursa harbor the cytolytic phase of MDV replication cycle...
  10. doi Characterization of responses elicited by Toll-like receptor agonists in cells of the bursa of Fabricius in chickens
    Michael St Paul
    Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada
    Vet Immunol Immunopathol 149:237-44. 2012
    ..The aim of the present study was to elucidate the responses mounted by cells of the bursa of Fabricius to treatment with the TLR 3, 4 and 21 ligands, poly I:C, lipopolysaccharide (LPS) and CpG ..
  11. ncbi Early replication in pulmonary B cells after infection with Marek's disease herpesvirus by the respiratory route
    B J G Baaten
    Institute for Animal Health, Compton, Newbury, Berkshire, UK
    Viral Immunol 22:431-44. 2009
    ..Together the data described here demonstrate the role of pulmonary B cells as the primary and predominant target cells and their importance for MDV pathogenesis...
  12. doi Dietary vanadium induces lymphocyte apoptosis in the bursa of Fabricius of broilers
    Wei Cui
    Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Ya an, Sichuan, 625014, China
    Biol Trace Elem Res 146:59-67. 2012
    The purpose of this 42-day study was to investigate the apoptosis in the bursa of Fabricius induced by different levels of dietary vanadium...
  13. ncbi Pathology of the thymus, spleen and bursa of Fabricius in zinc-deficient ducklings
    Hengmin Cui
    College of Animal Science and Veterinary Medicine Sichuan Agricultural University Yaan 625014 Sichuan, China
    Avian Pathol 32:259-64. 2003
    The weight and growth index of bursa of Fabricius, thymus and spleen were significantly reduced (P<0.05 or P<0.01) in zinc (Zn)-deficient ducks (Zn 22.9 mg/kg diet) when compared with normal ducks...
  14. ncbi Effects of early age feed restriction and heat conditioning on heat shock protein 70 expression, resistance to infectious bursal disease, and growth in male broiler chickens subjected to heat stress
    P K Liew
    Department of Animal Science, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia
    Poult Sci 82:1879-85. 2003
    ..We concluded that FRHT could improve weight gain and resistance to IBD in male broiler chickens under heat stress conditions. The improved heat tolerance and disease resistance in FRHT birds could be attributed to better HSP 70 response...
  15. ncbi Infectious bursal disease virus: strains that differ in virulence differentially modulate the innate immune response to infection in the chicken bursa
    Ibrahim Eldaghayes
    Institute for Animal Health, Compton, Berkshire, United Kingdom
    Viral Immunol 19:83-91. 2006
    ..This suggests that both viruses modulate the host immune response, although probably by using different mechanisms...
  16. ncbi Role of intrabursal T cells in infectious bursal disease virus (IBDV) infection: T cells promote viral clearance but delay follicular recovery
    S Rautenschlein
    Department of Veterinary Pathobiology, University of Minnesota, St Paul, Minnesota, USA
    Arch Virol 147:285-304. 2002
    ..The target organ of IBDV, the bursa of Fabricius, of Tx-CsA-birds had a significantly higher antigen load than the one of T cell-intact birds (P < 0.05)...
  17. pmc The contribution of Bruce Glick to the definition of the role played by the bursa of Fabricius in the development of the B cell lineage
    D Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy
    Clin Exp Immunol 145:1-4. 2006
    In 1956, Bruce Glick and Timothy Chang reported that the bursa of Fabricius plays an important role in antibody production...
  18. ncbi BASH, a novel signaling molecule preferentially expressed in B cells of the bursa of Fabricius
    R Goitsuka
    Inheritance and Variation Group, PREST, JST, Kyoto, Japan
    J Immunol 161:5804-8. 1998
    The bursa of Fabricius is a gut-associated lymphoid organ that is essential for the generation of a diversified B cell repertoire in the chicken. We describe here a novel gene preferentially expressed in bursal B cells...
  19. ncbi Age-related changes in the avian primary lymphoid organs (thymus and bursa of Fabricius)
    Emilia Ciriaco
    Dipartimento di Morfologia, Biochimica, Fisiologia e Produzioni Animali, Universita di Messina, Italy
    Microsc Res Tech 62:482-7. 2003
    The avian primary lymphoid organs, the thymus and the bursa of Fabricius, undergo age-dependent changes leading in some cases to the complete atrophy of the organ...
  20. ncbi Relative quantification and detection of different types of infectious bursal disease virus in bursa of Fabricius and cloacal swabs using real time RT-PCR SYBR green technology
    Y P Li
    Department of Poultry, Fish and Fur Animals, Danish Institute for Food and Veterinary Research, Hangøvej 2, DK 8200 Aarhus N, Denmark
    Res Vet Sci 82:126-33. 2007
    ..virulent strain DK01, classic strain F52/70 and vaccine strain D78 were quantified and detected in infected bursa of Fabricius (BF) and cloacal swabs using quantitative real time RT-PCR with SYBR green dye...
  21. ncbi Immunoglobulin gene conversion: insights from bursal B cells and the DT40 cell line
    Hiroshi Arakawa
    GSF, Institute for Molecular Radiobiology, Neuherberg Munich, Germany
    Dev Dyn 229:458-64. 2004
    ..their immunoglobulin (Ig) light and heavy chain genes by pseudogene templated gene conversion within the bursa of Fabricius. Although Ig gene conversion was initially believed to occur only in birds, it is now clear that most farm ..
  22. pmc The 9-1-1 DNA clamp is required for immunoglobulin gene conversion
    Alihossein Saberi
    Department of Radiation Genetics, Kyoto University Graduate School of Medicine, Yoshida Konoe, Sakyo ku, Kyoto 606 8501, Japan
    Mol Cell Biol 28:6113-22. 2008
    ..This suggests that the roles of Rad9 and Rad17 may be confined to a subset of homologous recombination reactions initiated by replication-stalling lesions rather than those associated with double-strand break repair...
  23. ncbi DNA vaccination with plasmids containing various fragments of large segment genome of infectious bursal disease virus
    Hua Chen Chang
    Department of Veterinary Pathobiology, 1175 ADDL, Purdue University, West Lafayette, IN 47907, USA
    Vaccine 21:507-13. 2003
    ..The results indicate that inclusion of VP2 gene in the plasmid DNA is essential in achieving effective protection mediated by DNA vaccination against IBDV infection in chickens...
  24. ncbi Partial protection against infectious bursal disease virus through DNA-mediated vaccination with the VP2 capsid protein and chicken IL-2 genes
    Diane J Hulse
    Department of Pathobiology, University of Florida, 2015 SW 16th Ave Gainesville, FL 32611, USA
    Vaccine 22:1249-59. 2004
    ..It was also found that immunological tolerance may have been induced in one of the chicken experiments by vaccination with plasmid DNA...
  25. ncbi Protection against very virulent infectious bursal disease virus in chickens immunized with DNA vaccines
    Soo Joung Kim
    Department of Veterinary Medicine, Kangwon National University, Chunchon 200 701, Republic of Korea
    Vet Microbiol 101:39-51. 2004
    ....
  26. ncbi Efficacy and safety of an infectious bursal disease virus intermediate vaccine in ovo
    M Coletti
    Dipartimento di Scienze Biopatologiche Veterinarie, , Italy
    Avian Dis 45:1036-43. 2001
    ..In commercial chickens, immunoresponse to NDV vaccination was not influenced by in ovo vaccination...
  27. ncbi The effect of co-administration of DNA carrying chicken interferon-gamma gene on protection of chickens against infectious bursal disease by DNA-mediated vaccination
    Ming Kun Hsieh
    Department of Veterinary Pathobiology, School of Veterinary Medicine, Purdue University, West Lafayette, IN 47907 2065, USA
    Vaccine 24:6955-65. 2006
    ..The results indicated that co-administration of plasmid encoding chicken IFN-gamma gene with plasmid encoding a large segment gene of the IBDV did not enhance immune response and protection against challenge by IBDV...
  28. pmc Effects of DDA, CpG-ODN, and plasmid-encoded chicken IFN-gamma on protective immunity by a DNA vaccine against IBDV in chickens
    Ha Jung Roh
    School of Veterinary Medicine and Institute of Veterinary Science, Kangwon National University, Chuncheon 200 701, Korea
    J Vet Sci 7:361-8. 2006
    ..These results suggest that DDA actually compromises the protection against the IBDV by DNA vaccine, and CpG-ODN and IFN-gamma had no significant effect...
  29. ncbi Avian adenovirus CELO recombinants expressing VP2 of infectious bursal disease virus induce protection against bursal disease in chickens
    Achille Francois
    Agence Francaise de Securite Sanitaire des Aliments, Molecular Biology Unit, Zoopole les Croix, B P 53, Ploufragan 22440, France
    Vaccine 22:2351-60. 2004
    ..After challenge, the weight ratio Bursa of Fabricius/body was about 2.5 per thousand, a value similar to that obtained with the commercial Bur706 vaccine...
  30. ncbi A recombinant turkey herpesvirus expressing chicken interleukin-2 increases the protection provided by in ovo vaccination with infectious bursal disease and infectious bronchitis virus
    I Tarpey
    Intervet UK, Walton Manor, Walton, Milton Keynes, Bucks MK7 7AJ, UK
    Vaccine 25:8529-35. 2007
    ..This suggests that the co-delivery of IL-2/HVT with low doses of other vaccines in ovo may be one method to increase the number of vaccines that can be given safely and efficaciously via in ovo vaccination...
  31. doi Effective protection by high efficiency bicistronic DNA vaccine against infectious bursal disease virus expressing VP2 protein and chicken IL-2
    Sachin Kumar
    Virginia Maryland Regional College of Veterinary Medicine, College Park, MD 20742, USA
    Vaccine 27:864-9. 2009
    ..The virus affects the lymphoid tissues of chickens, mainly the B cells of bursa of Fabricius, leading to severe and prolonged immunosuppression...
  32. ncbi Priming with DNA vaccine and boosting with killed vaccine conferring protection of chickens against infectious bursal disease
    Ming Kun Hsieh
    Department of Comparative Pathobiology, School of Veterinary Medicine, 406 S University Street, Purdue University, West Lafayette, IN 47907, USA
    Vaccine 25:5417-27. 2007
    ....
  33. pmc Analysis of gene expression during myc oncogene-induced lymphomagenesis in the bursa of Fabricius
    P E Neiman
    Divisions of Basic Sciences and Human Biology, Fred Hutchinson Cancer Research Center and the Departments of Medicine and Pathology, University of Washington, 1100 Fairview Avenue North, Seattle, WA 98109 1024, USA
    Proc Natl Acad Sci U S A 98:6378-83. 2001
    ..In follicles of the chicken bursa of Fabricius, myc induction of B-cell neoplasia requires a target cell population present during early bursal development ..
  34. ncbi Enhanced immunopathology induced by very virulent infectious bursal disease virus
    A E Williams
    Division of Immunology and Pathology, Institute for Animal Health, Compton Newbury, Berkshire, RG20 7NN, UK
    Avian Pathol 34:4-14. 2005
    ..The marked influx of T cells into the infected bursa indicates that cell-mediated immunity is likely to be important in the clearance of vvIBDV...
  35. ncbi Infectious bursal disease virus-induced immunosuppression in the chick is associated with the presence of undifferentiated follicles in the recovering bursa
    David R Withers
    Institute for Animal Health, Compton, Newbury, Berkshire, RG20 7NN, UK
    Viral Immunol 18:127-37. 2005
    ..Most severe depletion occurs in the bursa of Fabricius, where the immunoglobulin repertoire is developed by gene conversion...
  36. ncbi Modeling a whole organ using proteomics: the avian bursa of Fabricius
    Fiona M McCarthy
    Department of Basic Science, College of Veterinary Medicine, Mississippi State University, Mississippi State, MS 39762 6100, USA
    Proteomics 6:2759-71. 2006
    ..Here we used the chicken bursa of Fabricius, a common experimental system for B cell function, to model organ function from proteomics data...
  37. ncbi Genomic instability during Myc-induced lymphomagenesis in the bursa of Fabricius
    P E Neiman
    Division of Basic Science, Fred Hutchinson Cancer Research Center and Department of Medicine, University of Washington, Seattle, WA 98109 1024, USA
    Oncogene 25:6325-35. 2006
    ..Palindromic loci in TF and tumors, however, were expressed, many at high levels, suggesting an abundance of RNA species with long double-stranded segments generated during tumorigenesis...
  38. pmc A large database of chicken bursal ESTs as a resource for the analysis of vertebrate gene function
    I Abdrakhmanov
    Heinrich Pette Institut for Experimental Virology and Immunology, Department of Cellular Immunology, 20251 Hamburg, Germany
    Genome Res 10:2062-9. 2000
    Chicken B cells create their immunoglobulin repertoire within the Bursa of Fabricius by gene conversion...
  39. ncbi Functional genomic analysis reveals distinct neoplastic phenotypes associated with c-myb mutation in the bursa of Fabricius
    Paul E Neiman
    Divisions of Basic Science and Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Oncogene 22:1073-86. 2003
    ..This functional genomic analysis uncovered several different pathways of lymphomagenesis by oncogenic transcription factors acting in a B-cell lineage...
  40. ncbi Monoclonal antibodies against chicken Bu-1a and Bu-1b alloantigens
    T Veromaa
    Department of Medical Microbiology, Turku University, Finland
    Hybridoma 7:41-8. 1988
    ..MAbs against both allelic Bu-1 antigens are beneficial tools e.g. in typing of chicken lines and in studies on chicken B cell differentiation...
  41. ncbi Regulation of chicken haemopoiesis by cytokines
    C Siatskas
    Department of Pathology and Immunology, Monash University Medical School, Commercial Road, Prahran, 3181, Melbourne, Australia
    Dev Comp Immunol 24:37-59. 2000
    ....
  42. ncbi The diffusely-infiltrated lymphoid tissue of the bursa of Fabricius of Sturnus unicolor. Histological organization and functional significance
    J Fonfria
    Department of Cell Biology, Faculty of Biology, Complutense University, Madrid, Spain
    Histol Histopathol 9:333-8. 1994
    In the present study we confirm and extend previous reports about the existence of a T-dependent area in the bursa of Fabricius of some birds, analyzing ultrastructurally the cell content of the so-called diffusely-infiltrated lymphoid ..
  43. ncbi Efficacy of DNA vaccines against infectious bursal disease virus in chickens enhanced by coadministration with CpG oligodeoxynucleotide
    Xiaoquan Wang
    College of Veterinary Medicine, Nanjing Agriculture University, Nanjing 210095, China
    Avian Dis 47:1305-12. 2003
    ..These results suggest that coadministration of the constructed plasmid pcDNA3.1-VP2 or pCI-VP2 with CpG ODN or commercial attenuated IBD vaccine could protect chickens efficiently from direct vvIBDV challenge...
  44. ncbi The avian B-cell receptor complex: distinct roles of Igalpha and Igbeta in B-cell development
    Kelly A Pike
    Department of Immunology, University of Toronto, Toronto, Ontario, Canada
    Immunol Rev 197:10-25. 2004
    The bursa of Fabricius has evolved in birds as a gut-associated site of B-cell lymphopoiesis that is segregated from the development of other hematopoietic lineages...
  45. ncbi Virus strains from a flock exhibiting unusually high mortality due to infectious bursal disease
    J Ignjatovic
    CSIRO Livestock Industries, Australian Animal Health Laboratory, Private Bag No 24, Geelong, Victoria 3220
    Aust Vet J 82:763-8. 2004
    ..To characterise infectious bursal disease viruses (IBDVs) isolated from commercial broiler flocks exhibiting unusually high mortality due to infectious bursal disease (IBD)...
  46. ncbi A comparison of immune responses to infection with virulent infectious bursal disease virus (IBDV) between specific-pathogen-free chickens infected at 12 and 28 days of age
    Silke Rautenschlein
    Clinic for Poultry, University of Veterinary Medicine Hannover, Bunteweg 17, 30559 Hannover, Germany
    Vet Immunol Immunopathol 115:251-60. 2007
    ..Under these experimental conditions, age-related differences were found only for the cytokine patterns but interestingly this did not influence the outcome of the disease with IBDV-IM...
  47. ncbi Very virulent infectious bursal disease virus in Egypt: epidemiology, isolation and immunogenicity of classic vaccine
    M K Hassan
    Animal Health Research Institute, Dokki, Giza, Egypt
    Vet Res Commun 28:347-56. 2004
    ..However, the immune responses generated by 1 x, 10 x or 100 x vaccine doses did not protect against bursal damage following challenge. This finding points to the highly invasive nature of the prevailing vvIBDVs in Egypt...
  48. doi Direct detection of infectious bursal disease virus from clinical samples by in situ reverse transcriptase-linked polymerase chain reaction
    Tereza C Cardoso
    Sao Paulo State University, UNESP Laboratorio de Virologia, DAPSA, Brasil
    Avian Pathol 37:457-61. 2008
    ..of the very virulent (vv) Brazilian strain of infectious bursal disease virus (IBDV) was determined in the bursa of Fabricius, thymus and liver of 2-week-old broilers from a flock with a higher than expected mortality...
  49. ncbi Infiltration by CD4+ and CD8+ lymphocytes in bursa of chickens infected with Infectious Bursal Disease Virus (IBDV): strain-specific differences
    Bhawna Poonia
    Department of Veterinary Microbiology, CCS Haryana Agricultural University, Hisar 125 004, India
    Indian J Exp Biol 42:823-9. 2004
    In order to investigate if there is any definite correlation between the degree of T-cell response in the bursa of Fabricius (BF) and the virulence of Infectious Bursal Disease (IBD) virus strains, chickens were infected with strains of ..
  50. ncbi Protection conferred by coarse spray vaccination against challenge with infectious bursal disease virus in commercial broilers
    Alejandro Banda
    Department of Population Health, College of Veterinary Medicine, University of Georgia, Athens, GA 30602 4875, USA
    Avian Dis 52:297-301. 2008
    ..70 and did not differ from the unvaccinated-unchallenged control group. These results suggest that coarse spray vaccination can be considered as another tool to control IBDV in the field...
  51. ncbi Effect of a variant infectious bursal disease virus (E/Del) on Salmonella typhimurium infection in commercial broiler chickens
    D A Bautista
    Virginia Maryland Regional College of Veterinary Medicine, 8075 Greenmead Drive, University of Maryland, College Park, MD 20742 3711, USA
    Avian Dis 48:361-9. 2004
    ....
  52. ncbi Spontaneous colibacillosis in infectious bursal disease-affected broiler flocks
    M Mitra
    West Bengal University of Animal and Fishery Sciences, Kolkata, India
    Trop Anim Health Prod 36:627-32. 2004
  53. ncbi Protection against infectious bursal disease virulent challenge conferred by a recombinant avian adeno-associated virus vaccine
    F Perozo
    Poultry Diagnostic and Research Center, University of Georgia, Athens, GA 30602, USA
    Avian Dis 52:315-9. 2008
    ..rAAAV-VP2 vaccination induced protective immunity against IBDV challenge in 80% of the birds, without compromising the bursa of Fabricius. The use of rAAAV virions for gene delivery represents a novel approach to poultry vaccination.
  54. ncbi Comparative analysis of viral RNA and apoptotic cells in bursae following infection with infectious bursal disease virus
    Lih L Kong
    Faculty of Veterinary Medicine, Universiti Putra Malaysia, UPM Serdang, 43400 Selangor, Malaysia
    Comp Immunol Microbiol Infect Dis 27:433-43. 2004
    ..i. This study indicates that UPM97/61 and UPM94/273 have different efficiency of replication and percentage of apoptotic cells in bursae during the acute phase of IBDV infection...
  55. ncbi Reversion of molecularly engineered, partially attenuated, very virulent infectious bursal disease virus during infection of commercial chickens
    R Raue
    Institute for Virology, Faculty of Veterinary Medicine University of Leipzig D 04103 Leipzig
    Avian Pathol 33:181-9. 2004
    ..the disease, with delayed and milder pathological lesions followed by quick follicular regeneration in the bursa of Fabricius in BD-3tc-inoculated birds, suggested that these amino acid substitutions made BD-3tc partially attenuated...
  56. ncbi Infectious bursal disease virus polyprotein expression arrests growth and mitogenic stimulation of B lymphocytes
    M A Peters
    Department of Veterinary Pathobiology, Purdue University, West Lafayette, Indiana 47907 2065, USA
    Arch Virol 149:2413-26. 2004
    ..The expression of the mature viral proteins VP2, VP4 or VP3 did not change the rate of cell proliferation or response of B cell cultures to mitogen. The results suggested that IBDV polyprotein is a mediator of immunosuppression...
  57. ncbi Enhancement of the immunogenicity of DNA vaccine against infectious bursal disease virus by co-delivery with plasmid encoding chicken interleukin 2
    Jianrong Li
    Institute of Preventive Veterinary Medicine, College of Animal Science, Zhejiang University, Hangzhou, Zhejiang 310029, PR China
    Virology 329:89-100. 2004
    ..These results strongly indicate that the efficacy of avian DNA vaccine can be modulated by co-administration of a plasmid encoding chIL-2...
  58. ncbi Interference between mild and pathogenic strains of infectious bursal disease virus in chickens
    S Ashraf
    Food Animal Health Research Program, Department of Veterinary Preventive Medicine, Ohio Agricultural Research and Development Center, The Ohio State University, 1680 Madison Avenue, Wooster, OH 44691, USA
    Avian Dis 49:99-103. 2005
    ..The interference phenomenon observed might be due to competition for host receptor sites or production of cytokine(s). This interference phenomenon could have practical implications for vaccine usage and protection...
  59. ncbi Temporal and spatial analysis of the 1999 outbreak of acute clinical infectious bursal disease in broiler flocks in Denmark
    J Sanchez
    Department of Health Management, Atlantic Veterinary College, Charlottetown, PEI, Canada C1A 4P3
    Prev Vet Med 71:209-23. 2005
    ..The analysis for the full hierarchical structure of the dataset identified variation (i.e. clustering) at the farm and municipality levels...
  60. ncbi Preparation and evaluation of Vero-cell infectious bursal disease vaccine in Pakistan
    Muhammad Hidayat Rasool
    Department of Veterinary Microbiology, Faculty of Veterinary Sciences, University of Agriculture, Faisalabad 38040, Pakistan
    Vaccine 24:2810-4. 2006
    ..All the birds in control group showed sever bursal lesions post-challenge. The study indicated newly developed infectious bursal disease vaccine was found to be safe and immunogenic...
  61. pmc Diversified bursal medullary B cells survive and expand independently after depletion following neonatal infectious bursal disease virus infection
    David R Withers
    Institute for Animal Health, Compton, UK
    Immunology 117:558-65. 2006
    ..in proliferating immature B cells within the follicles of a specialized gut-associated lymphoid organ, the bursa of Fabricius. Neonatal infection with infectious bursal disease virus can eliminate almost the entire bursal B-cell ..
  62. ncbi The use of gamma irradiation for the inactivation of infectious bursal disease viruses
    D J Jackwood
    Food Animal Health Research Program, The Ohio Agricultural Research and Development Center, The Ohio State University, 1680 Madison Avenue, Wooster, OH 44691, USA
    Avian Dis 51:606-8. 2007
    ..6-2.0 logs after the 10 kGy exposure; however, these viruses remained viable after this treatment. Gamma irradiation is not an effective intervention to reduce the risk of IBDV introduction via processed poultry...
  63. ncbi Oral DNA vaccination with the polyprotein gene of infectious bursal disease virus (IBDV) delivered by the attenuated Salmonella elicits protective immune responses in chickens
    Long Li
    Institute of Protective Veterinary, College of Animal Science, Zhejiang University, Hangzhou, 310029, PR China
    Vaccine 24:5919-27. 2006
    ..Our results have implications in the development of DNA vaccines against avian viral diseases by bacteria-vectored oral delivery system...
  64. ncbi Effect of infectious bursal disease virus insult on iron, copper, and zinc concentration in liver, bursa of Fabricius, spleen, pancreas, and serum of chickens
    C Blackmore
    Department of Population, Health and Reproduction, School of Veterinary Medicine, University of California, Davis 95616, USA
    Avian Dis 50:303-5. 2006
    ..Liver, bursa of Fabricius, pancreas, spleen, and serum were sampled in 10 controls and 10 challenged chickens at 3-day intervals ..
  65. ncbi Detection of infectious bursal disease virus from formalin-fixed paraffin-embedded tissue by immunohistochemistry and real-time reverse transcription-polymerase chain reaction
    Mohamed M Hamoud
    Department of Population Health, College of Veterinary Medicine, University of Georgia, Athens, Georgia 30602, USA
    J Vet Diagn Invest 19:35-42. 2007
    ..Optimal fixation conditions for IHC detection of IBDV were 10% formalin concentration, pH 7.0, and temperature of 4 degrees C, where maximum intensity of immunostaining was observed...
  66. ncbi Molecular analysis of infectious bursal disease virus from bursal tissues collected on FTA filter paper
    Hugo Moscoso
    Poultry Diagnostic and Research Center, Department of Population Health, The University of Georgia, Athens, GA 30602 4875, USA
    Avian Dis 50:391-6. 2006
    ....
  67. ncbi Pivotal role of ChIFNgamma in the pathogenesis and immunosuppression of infectious bursal disease
    Fabienne Rauw
    Avian Virology and Immunology Unit, Veterinary and Agrochemical Research Centre, Ukkel Brussels, Belgium
    Avian Pathol 36:367-74. 2007
    ..Two weeks after viral inoculation, T lymphocytes infiltrating the bursa of Fabricius had recovered their activation capability...
  68. ncbi Protective efficacy of intermediate and intermediate plus infectious bursal disease virus (IBDV) vaccines against very virulent IBDV in commercial broilers
    S Rautenschlein
    Clinic for Poultry, Veterinary School Hannover, Bunteweg 17, 30559 Hannover, Germany
    Avian Dis 49:231-7. 2005
    ..To be able to evaluate vaccine efficacy in commercial broilers, parameters such as intrabursal IBDV-antigen load should also be considered in conjunction with bursa lesion scores...
  69. ncbi Genotyping of Canadian field strains of infectious bursal disease virus
    Davor Ojkic
    Animal Health Laboratory, University of Guelph, Ontario, Guelph, Canada
    Avian Pathol 36:427-33. 2007
    ..2% to 98.3%, to US IBDV strain 586. Five samples contained vaccine-related viruses, while two field strains showed the best match to Del A (United States) and IBDV strains SP_04_02 (Spain). Very virulent IBDVs were not detected in Canada...
  70. ncbi Infection and activation of bursal macrophages by virulent infectious bursal disease virus
    Mahesh Khatri
    Department of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, 1971 Commonwealth Avenue, St Paul, MN 55108, USA
    Virus Res 113:44-50. 2005
    ..These data suggested that B cells may not be the sole targets for the virus; macrophages and possibly other cells may serve as host for IBDV...
  71. ncbi Differences in the immunopathogenesis of infectious bursal disease virus (IBDV) following in ovo and post-hatch vaccination of chickens
    Silke Rautenschlein
    Clinic for Poultry, School of Veterinary Medicine Hannover, Bunteweg 17, 30559 Hannover, Germany
    Vet Immunol Immunopathol 106:139-50. 2005
    ..In ovo-vaccinated birds recovered significantly faster from lesions of the bursa of Fabricius than post-hatch vaccinated (P<0.05)...
  72. ncbi A field study on the significance of vaccination against infectious bursal disease virus (IBDV) at the optimal time point in broiler flocks with maternally derived IBDV antibodies
    Hermann Block
    Poultry Practice Meyer Block, Uelsen, Germany
    Avian Pathol 36:401-9. 2007
    ..The late incidence of bursa lesions after vaccination may be confused with field virus-induced lesions, in which case sequencing may offer a valuable tool for differentiation...
  73. ncbi Effects of dietary ratio of linoleic to linolenic acid on performance, antibody production, and in vitro lymphocyte proliferation in two strains of leghorn pullet chicks
    U Puthpongsiriporn
    Charoen Pokphand Group Co, Ltd, Bangkok 105000, Thailand
    Poult Sci 84:846-57. 2005
    ..These results indicate that feeding a reduced dietary ratio of linoleic to linolenic acid by adding flaxseed to the diets enhanced antibody response to NDV and IBDV vaccines without any negative effects on pullet performance...
  74. pmc Delayed vaccine virus replication in chickens vaccinated subcutaneously with an immune complex infectious bursal disease vaccine: quantification of vaccine virus by real-time polymerase chain reaction
    Judit Iván
    Veterinary Medical Research Institute, Hungarian Academy of Sciences, Budapest, Hungary
    Can J Vet Res 69:135-42. 2005
    ..Only the bursa of Fabricius was found to be positive with unusually long viral persistence in the broiler group...
  75. ncbi Development of recombinant VP2 vaccine for the prevention of infectious bursal disease of chickens
    Jun Rong
    Department of Biochemistry, College of Life Science, Wuhan University, Wuhan, Hubei 430072, PR China
    Vaccine 23:4844-51. 2005
    ..7% chickens. The results indicate that E. coli BL 21/pET 28 a-VP2 could be used to develop recombinant VP2 vaccine against infectious bursal disease in chickens...
  76. ncbi Real-time RT-PCR analysis of two epitope regions encoded by the VP2 gene of infectious bursal disease viruses
    C S Mickael
    Food Animal Health Research Program, Ohio Agricultural Research and Development Center, The Ohio State University, 1680 Madison Ave, Wooster, OH 44691, USA
    J Virol Methods 128:37-46. 2005
    ..Real-time RT-PCR can be a useful tool to assist in the development of more effective vaccination strategies...
  77. ncbi Identification of infectious bursal disease viruses from RNA extracted from paraffin-embedded tissue
    Mohamed M Hamoud
    Department of Population Health, Poultry Diagnostic and Research Center, College of Veterinary Medicine The University of Georgia, Athens, GA 30602, USA
    Avian Dis 50:476-82. 2006
    ..The ability to identify the actual virus strain associated with the lesions observed microscopically in the bursa of Fabricius allowed for direct correlation between viral identity and lesions, which may help in designing vaccination ..
  78. ncbi Infectious bursal disease virus and proventriculitis in broiler chickens
    Mary J Pantin-Jackwood
    Department of Avian Medicine, College of Veterinary Medicine, University of Georgia, Athens, GA 30602 3875, USA
    Avian Dis 47:681-90. 2003
    ..We conclude that naturally occurring proventriculitis can occur in the absence of IBDV and that the IBDV strains tested do not directly produce proventriculitis or induce increased proventricular apoptosis...
  79. ncbi Detection and persistence of infectious bursal disease virus in specific-pathogen-free and commercial broiler chickens
    G A Abdel-Alim
    Food Animal Health Research Program, Ohio Agricultural Research and Development Center, The Ohio State University, Wooster 44691, USA
    Avian Dis 45:646-54. 2001
    ..This prompted us to investigate the persistence of IBDV or its RNA in the bursa of Fabricius (BF) of inoculated and vaccinated SPF chicks and of inoculated and vaccinated commercial broiler chicks that ..
  80. ncbi Pathogenicity of embryo-adapted serotype 2 OH strain of infectious bursal disease virus in chickens and turkeys
    G A Abdel-Alim
    Food Animal Health Research Program, Ohio Agricultural Research and Development Center, The Ohio State University, Wooster, OH 44691, USA
    Avian Dis 46:1001-6. 2002
    ..SPF chickens and turkey poults as indicated by lack of clinical signs, gross or microscopic lesions in the bursa of Fabricius of inoculated birds...
  81. ncbi The value of tissue imprint hybridization for rapid detection of infectious bursal disease virus from field outbreaks
    M Parthiban
    Department of Animal Biotechnology, Madras Veterinary College, Chennai 600 007, Tamil Nadu, India
    Trop Anim Health Prod 34:391-8. 2002
    ..Tissue imprint hybridization was found to be a more sensitive method than conventional antigen detection assays...
  82. ncbi Characterization of the antigenic, immunogenic, and pathogenic variation of infectious bursal disease virus due to propagation in different host systems (bursa, embryo, and cell culture). II. Antigenicity at the epitope level
    Isaac R Rodriguez-Chavez
    Department of Animal and Food Sciences, Allen Biotechnology Laboratory, University of Delaware, 601 Sincock Lane, Newark, DE 19717, USA
    Avian Pathol 31:473-83. 2002
    Antigenic variation of infectious bursal disease virus (IBDV) due to propagation in different host systems (bursa of Fabricius, embryos, or cell cultures) was determined by enzyme-linked immunosorbent assay (indirect and antigen capture) ..
  83. ncbi Cloning and nucleotide analysis of segment A gene of infectious bursal disease virus detected in Korea
    Toh Kyung Kim
    Gyeongnam Livestock Promotion Institute, Chinju 660 985, South Korea
    Virus Genes 26:97-106. 2003
    ..The nucleotide and amino acid sequences of the Chinju strain with pertinent information can be useful for the development of genetically engineered vaccines and diagnostic reagents against vvIBDV...
  84. ncbi Characterization of the antigenic, immunogenic, and pathogenic variation of infectious bursal disease virus due to propagation in different host systems (bursa, embryo, and cell culture). III. Pathogenicity
    Isaac R Rodriguez-Chavez
    Department of Animal and Food Sciences, Allen Biotechnology Laboratory, University of Delaware, 601 Sincock Lane, Newark, DE 19717, USA
    Avian Pathol 31:485-92. 2002
    ..Edgar and STC) infectious bursal disease virus (IBDV) strains were observed after propagation in the bursa of Fabricius, embryos, or cell cultures...
  85. ncbi Differentiation of infectious bursal disease viruses isolated in Croatia
    I Lojkic
    Department of Poultry Pathology, Faculty of Veterinary Medicine, University of Zagreb, Zagreb, Croatia
    Avian Dis 47:59-65. 2003
    ..The TaqI restriction at nt position 875 suggests that the IBDV in GUMBOKAL SPF vaccine could belong to the mild strains...
  86. ncbi Evaluation of the immune response and detection of infectious bursal disease viruses by reverse transcriptase-polymerase chain reaction and enzyme-linked immunosorbent assay after in ovo vaccination of commercial broilers
    Michelle M Corley
    102 Milbank Hall, Department of Agriculture and Environmental Sciences, Tuskegee University, Tuskegee, AL 36088, USA
    Avian Dis 46:803-9. 2002
    ..The IBDV-Icx RNA was evident in tissues and could induce protection against challenge. This work gives further insight into the mechanism of the IBDV-Icx vaccine...
  87. ncbi Quantitative measures of disease in broiler breeder chicks of different major histocompatibility complex genotypes after challenge with infectious bursal disease virus
    J C Hudson
    Department of Pathobiology, College of Veterinary Medicine, Auburn University, AL 36849 5519, USA
    Avian Dis 46:581-92. 2002
    ..Results indicated that there was no difference among the 3 MHC genotypes in incidence of IBD by any of the disease measures...
  88. ncbi Genetic resistance of Egyptian chickens to infectious bursal disease and Newcastle disease
    M K Hassan
    Animal Health Research Institute, Dokki, Giza 12618, Egypt
    Trop Anim Health Prod 36:1-9. 2004
    ..Further studies on the resistance mechanism are warranted...
  89. ncbi Pathogenicity of cell culture-derived and bursa-derived infectious bursal disease viruses in specific-pathogen-free chickens
    G A Abdel-Alim
    Food Animal Health Research Program, Ohio Agricultural Research and Development Center, The Ohio State University, Wooster 44691, USA
    Avian Dis 45:844-52. 2001
    ..Virus replication in the bursa of Fabricius was investigated by virus isolation in SPF chicken embryos, immune electron microscopy (IEM), ..
  90. ncbi Detection of infectious bursal disease vaccine viruses in lymphoid tissues after in ovo vaccination of specific-pathogen-free embryos
    M M Corley
    Department of Poultry Science, Alabama Agricultural Experimental Station, Auburn University, 36849, USA
    Avian Dis 45:897-905. 2001
    ..Bursa weight: body weight ratios in IBDV-ICX-vaccinated unchallenged and vaccinated challenged birds were not different (P < 0.05)...
  91. ncbi Immune response and resistance to infectious bursal disease virus of chicken lines selected for high or low antibody response to Escherichia coli
    J Pitcovski
    MIGAL, Kiryat Shmona, Rosh-Pinah, Israel
    Poult Sci 80:879-84. 2001
    ..later, the chicks were challenged with a virulent strain of the virus and killed after 10 d; the ratio of bursa of Fabricius to 100 g BW was determined for each bird...
  92. ncbi Pathogenesis and tissue distribution of a variant strain of infectious bursal disease virus in commercial broiler chickens
    S Elankumaran
    VA MD Regional College of Veterinary Medicine, University of Maryland, College Park 20742 3711, USA
    Avian Dis 46:169-76. 2002
    ..transcription-polymerase chain reaction for IBDV-specific RNA extended the window of IBDV detection in the bursa of Fabricius to 6 wk PI...
  93. ncbi Major histocompatibility complex-linked immune response of young chickens vaccinated with an attenuated live infectious bursal disease virus vaccine followed by an infection
    H R Juul-Madsen
    Danish Institute of Agricultural Sciences, Tjele
    Poult Sci 81:649-56. 2002
    ..Nevertheless, the MHC haplotype-associated protective immunity was further supported by the bursa of Fabricius (bursa) recovery from the disease, as measured by histological scorings of the bursa...
  94. ncbi Comparison of the efficacies of a novel aspergillus niger mycelium with separate and combined effectiveness of phytase, acid phosphatase, and pectinase in dephosphorylation of wheat-based feeds fed to growing broilers
    K Zyła
    University of Agriculture, Department of Food Biotechnology, Krakow, Poland
    Poult Sci 79:1434-43. 2000
    ..Supplementation of wheat-based 0.17% NPP diets with FM increased bursa of Fabricius weights and reduced the intestinal surface covered by Peyer's patches.
  95. doi Histopathology, immunohistochemistry, in situ apoptosis, and ultrastructure characterization of the digestive and lymphoid organs of new type gosling viral enteritis virus experimentally infected gosling
    S Chen
    Avian Disease Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Ya an, Sichuan Province, 625014, China
    Poult Sci 89:668-80. 2010
    ..proventriculus, gizzard, small intestine, cecum, rectum, liver, and pancreas) and the lymphoid organs (bursa of Fabricius, thymus, Harderian gland, and spleen) of experimentally infected goslings, portions of tissues were ..
  96. doi Sensitive embryonic endpoints with in ovo treatment for detecting androgenic and anti-androgenic effects of chemicals in Japanese quail (Coturnix japonica)
    T Utsumi
    Environmental Health Science Laboratory, Sumitomo Chemical Co Ltd, Takarazuka, Hyogo 665 8555, Japan
    Poult Sci 88:1052-9. 2009
    ..examinations were performed in the cloacal gland, liver, kidneys, testes, ovaries, uropygial gland, and bursa of Fabricius. The cloacal gland consists of many glandular units (tubular gland structures) lined by developed or ..
  97. ncbi Development and regional expression of chicken neuroleukin (glucose-6-phosphate isomerase) messenger RNA
    F Hallbook
    Department of Medical Chemistry, Karolinska Institute, Stockholm, Sweden
    J Neurosci Res 23:142-51. 1989
    ..different tissues separately, NLK mRNA expression was found to decrease during development in the heart and bursa of Fabricius, whereas the level of mRNA in the brain showed a large increase shortly after hatching...
  98. doi Synergy of Astragalus polysaccharides and probiotics (Lactobacillus and Bacillus cereus) on immunity and intestinal microbiota in chicks
    S P Li
    College of Veterinary Medicine, Northwest A and F University, Yangling, Shaanxi, China, 712100
    Poult Sci 88:519-25. 2009
    ..05), and also in spleen index, bursa of Fabricius index, immune organ histological changes, and lactobacilli, Bacillus cereus, and E...
  99. ncbi Comparative pathological studies on domestic geese (Anser anser domestica) and Muscovy ducks (Cairina moschata) experimentally infected with parvovirus strains of goose and Muscovy duck origin
    R Glavits
    Central Veterinary Institute, H 1581 Budapest 146, Hungary
    Acta Vet Hung 53:73-89. 2005
    ..Other prominent lesions included hepatitis and atrophy (lymphocyte depletion) of the lymphoid organs (bursa of Fabricius, thymus, spleen)...
  100. doi Ultrastructure and electrolyte transport of the epithelium of coprodeum, colon and the proctodeal diverticulum of Rhea americana
    V S Elbrønd
    Department of Basic Animal and Veterinary Sciences, Faculty of Life Sciences, University of Copenhagen, DK 1870 Frederiksberg C, Denmark
    Comp Biochem Physiol A Mol Integr Physiol 152:357-65. 2009
    ..in lymphoid tissue arranged into lobuli bursales, and it was concluded that this structure is a modified bursa of Fabricius. The sparse interlobular epithelium of the diverticulum resembled that of colon and coprodeum...
  101. ncbi Infectious bursal disease virus of chickens: pathogenesis and immunosuppression
    J M Sharma
    Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Minnesota, St Paul, MN 55108, USA
    Dev Comp Immunol 24:223-35. 2000
    ..IgM+ cells serve as targets for the virus. The most extensive virus replication takes place in the bursa of Fabricius. The acute phase of the disease lasts for about 7-10 days...

Research Grants56

  1. Workshop On Experimental Models from Bursa of Fabricius
    Paul Neiman; Fiscal Year: 2002
    The workshop on Experimental Models from the Bursa of Fabricius will be held October 4-6, 2002, in the modern conference facilities of a leading biomedical research institute, the Fred Hutchinson Cancer Research Center, in Seattle, ..
  2. ENDOCRINE AND AUTOIMMUNE DISORDERS IN THYROIDITIS
    JOSEPH KITE; Fiscal Year: 1980
    ..Ultrastructural studies will be made of the thyroid, pituitary, thymus, and bursa of Fabricius to detect changes in basement membranes...
  3. AUTOIMMUNE THYROIDITIS IN OS CHICKENS
    Noel Rose; Fiscal Year: 1980
    ..in this disease a variety of comparative functional studies have been carried out on the thyroid, thymus and bursa of Fabricius prior to disease development...
  4. GENE CONVERSION IN MYC INDUCED BURSAL LYMPHOMAS
    Craig Thompson; Fiscal Year: 1999
    ..defining the mechanisms by which avian retroviruses induce B cell transformation during development in the bursa of Fabricius. When chickens are infected in the perinatal period with avian leukosis (ALV), a retrovirus that does not ..
  5. GENE CONVERSION IN MYC INDUCED BURSAL LYMPHOMAS
    Craig Thompson; Fiscal Year: 2001
    ..defining the mechanisms by which avian retroviruses induce B cell transformation during development in the bursa of Fabricius. When chickens are infected in the perinatal period with avian leukosis (ALV), a retrovirus that does not ..
  6. GENE CONVERSION IN MYC INDUCED BURSAL LYMPHOMAS
    Craig Thompson; Fiscal Year: 2000
    ..defining the mechanisms by which avian retroviruses induce B cell transformation during development in the bursa of Fabricius. When chickens are infected in the perinatal period with avian leukosis (ALV), a retrovirus that does not ..
  7. GENE CONVERSION IN MYC INDUCED BURSAL LYMPHOMAS
    Craig Thompson; Fiscal Year: 1999
    ..defining the mechanisms by which avian retroviruses induce B cell transformation during development in the bursa of Fabricius. When chickens are infected in the perinatal period with avian leukosis (ALV), a retrovirus that does not ..
  8. Structural basis of protein-primed RNA synthesis by birnaviruses
    Yizhi Tao; Fiscal Year: 2007
    ..best studied birnavirus, causes Gumboro disease in avian species by destroying immature B-lymphocytes in the Bursa of Fabricius. In addition to a VPg-linked genome, mature virion contains the major capsid proteins VP2 and VP3, the viral ..
  9. Structural basis of protein-primed RNA synthesis by birnaviruses
    Yizhi Tao; Fiscal Year: 2009
    ..best studied birnavirus, causes Gumboro disease in avian species by destroying immature B-lymphocytes in the Bursa of Fabricius. In addition to a VPg-linked genome, mature virion contains the major capsid proteins VP2 and VP3, the viral ..
  10. Structural basis of protein-primed RNA synthesis by birnaviruses
    Yizhi Jane Tao; Fiscal Year: 2010
    ..best studied birnavirus, causes Gumboro disease in avian species by destroying immature B-lymphocytes in the Bursa of Fabricius. In addition to a VPg-linked genome, mature virion contains the major capsid proteins VP2 and VP3, the viral ..
  11. NORMAL & NEOPLASTIC FUNCTION OF THE BCL-2 PROTO-ONCOGENE
    DONALD EWERT; Fiscal Year: 1992
    ..Beginning with our observation that overexpression of bcl-2 blocks apoptosis in immature B cells in the bursa of Fabricius, we will proceed to determine what effect bcl-2 deregulation has on the differentiation and maturation of B ..
  12. ANTIGEN ABSORPTION AND B CELL RESPONSE IN GUT
    DALE BOCKMAN; Fiscal Year: 1980
    ..In particular, the role of the epithelium and lymphcytes of Peyer's patches, appendix, and bursa of Fabricius in antigen absorption and production of plasma cells will be explored...
  13. Human immunotherapeutics for Biodefense Applications
    Philip Leighton; Fiscal Year: 2004
    ..processes required for antibody responses in the chicken, namely B cell development, proliferation in the bursa of Fabricius and migration to the periphery...
  14. REGULATION OF CELL DEATH IN CHICKEN BURSAL LYMPHOMA
    Ruey Min Lee; Fiscal Year: 1999
    ..in B cell development and neoplastic transformation by an experimental model system based on the chicken bursa of Fabricius. Preliminary data suggest that NR13 is expressed inversely with programmed cell death in normal and ..
  15. REGULATION OF CELL DEATH IN CHICKEN BURSAL LYMPHOMA
    Ruey Min Lee; Fiscal Year: 1999
    ..in B cell development and neoplastic transformation by an experimental model system based on the chicken bursa of Fabricius. Preliminary data suggest that NR13 is expressed inversely with programmed cell death in normal and ..
  16. REGULATION OF CELL DEATH IN CHICKEN BURSAL LYMPHOMA
    Ruey Min Lee; Fiscal Year: 2001
    ..in B cell development and neoplastic transformation by an experimental model system based on the chicken bursa of Fabricius. Preliminary data suggest that NR13 is expressed inversely with programmed cell death in normal and ..
  17. REGULATION OF CELL DEATH IN CHICKEN BURSAL LYMPHOMA
    Ruey Min Lee; Fiscal Year: 2002
    ..in B cell development and neoplastic transformation by an experimental model system based on the chicken bursa of Fabricius. Preliminary data suggest that NR13 is expressed inversely with programmed cell death in normal and ..
  18. REGULATION OF CELL DEATH IN CHICKEN BURSAL LYMPHOMA
    Ruey Min Lee; Fiscal Year: 2003
    ..in B cell development and neoplastic transformation by an experimental model system based on the chicken bursa of Fabricius. Preliminary data suggest that NR13 is expressed inversely with programmed cell death in normal and ..
  19. REGULATION OF CELL DEATH IN CHICKEN BURSAL LYMPHOMA
    Ruey Min Lee; Fiscal Year: 2000
    ..in B cell development and neoplastic transformation by an experimental model system based on the chicken bursa of Fabricius. Preliminary data suggest that NR13 is expressed inversely with programmed cell death in normal and ..
  20. LONG-LIVED LYMPHOCYTES AND SECRETORY BURSAL CELLS
    Bruce Glick; Fiscal Year: 1980
    Our research has revealed the presence of long- and short-lived lymphocytes in the avian thymus, bursa of Fabricius, spleen, and bone marrow. The latter lymphomyeloid tissue possesses the longest lived population of lymphocytes...
  21. MOLECULAR CLONING OF C-MYC TRANSCRIPTION FACTOR GENES
    Paul Neiman; Fiscal Year: 1992
    ..Neiman has characterized, namely the development and differentiation of avian B-cells in the bursa of Fabricius in which the controlled expression of the c-myc proto-oncogene plays an important role...
  22. RETROVIRUSES AND CANCER
    Paul Neiman; Fiscal Year: 1990
    ..Project 7 will attempt to determine the role of two oncogenes, myc and Blym-1, in specific stages of virus induced lymphomagenesis in the bursa of Fabricius in chickens.
  23. MOLECULAR MECHANISMS IN NEOPLASIA
    Paul Neiman; Fiscal Year: 2002
    ..The focus of this project is, a deeper understanding of the early development of the B-cell lineage in the bursa of Fabricius, and the perturbation of that development during induction of malignant lymphomas in the bursa by ..
  24. MOLECULAR MECHANISMS IN NEOPLASIA
    Paul Neiman; Fiscal Year: 1999
    The focus of this project is the analysis of multistage neoplastic change in B-cell lymphomas induced in the bursa of Fabricius by myc oncogenes...
  25. MOLECULAR MECHANISMS IN NEOPLASIA
    Paul Neiman; Fiscal Year: 2003
    ..The focus of this project is, a deeper understanding of the early development of the B-cell lineage in the bursa of Fabricius, and the perturbation of that development during induction of malignant lymphomas in the bursa by ..
  26. MOLECULAR MECHANISMS IN NEOPLASIA
    Paul Neiman; Fiscal Year: 2004
    ..The focus of this project is, a deeper understanding of the early development of the B-cell lineage in the bursa of Fabricius, and the perturbation of that development during induction of malignant lymphomas in the bursa by ..
  27. MOLECULAR MECHANISMS IN NEOPLASIA
    Paul Neiman; Fiscal Year: 2005
    ..The focus of this project is, a deeper understanding of the early development of the B-cell lineage in the bursa of Fabricius, and the perturbation of that development during induction of malignant lymphomas in the bursa by ..
  28. MOLECULAR MECHANISMS IN NEOPLASIA
    Paul Neiman; Fiscal Year: 2006
    ..The focus of this project is, a deeper understanding of the early development of the B-cell lineage in the bursa of Fabricius, and the perturbation of that development during induction of malignant lymphomas in the bursa by ..
  29. MOLECULAR MECHANISMS IN NEOPLASIA
    Paul Neiman; Fiscal Year: 2007
    ..associated with constitutive Myc oncogene over expression, and resultant lymphomagenesis, in the chicken bursa of Fabricius. We propose to characterize this phenomenon more completely...
  30. MOLECULAR MECHANISMS IN NEOPLASIA
    Paul Neiman; Fiscal Year: 2008
    ..associated with constitutive Myc oncogene over expression, and resultant lymphomagenesis, in the chicken bursa of Fabricius. We propose to characterize this phenomenon more completely...
  31. MOLECULAR MECHANISMS IN NEOPLASIA
    Paul Neiman; Fiscal Year: 1991
    ..The project is focussed on viral induction of lymphomas in the bursa of Fabricius as an experimental system, and includes relevant aspects of B-cell development, immunoglobulin (Ig) gene ..
  32. MOLECULAR MECHANISMS IN NEOPLASIA
    Paul Neiman; Fiscal Year: 1993
    ..The project is focussed on viral induction of lymphomas in the bursa of Fabricius as an experimental system, and includes relevant aspects of B-cell development, immunoglobulin (Ig) gene ..
  33. MOLECULAR MECHANISMS IN NEOPLASIA
    Paul Neiman; Fiscal Year: 1992
    ..The project is focussed on viral induction of lymphomas in the bursa of Fabricius as an experimental system, and includes relevant aspects of B-cell development, immunoglobulin (Ig) gene ..
  34. MOLECULAR MECHANISMS IN NEOPLASIA
    Paul Neiman; Fiscal Year: 1990
    ..The model system on which the majority of the proposed work is focused is the induction of lymphomas in the bursa of Fabricius of chickens by natural and genetically engineered retroviruses...
  35. MOLECULAR MECHANISMS IN NEOPLASIA
    Paul Neiman; Fiscal Year: 1980
    ..A tissue culture system for studying regulation of growth of endogenous viruses in chicken cells will be developed, and viral genetic elements required for regulation by the cell identified. ..
  36. MOLECULAR MECHANISMS IN NEOPLASIA
    Paul Neiman; Fiscal Year: 2000
    The focus of this project is the analysis of multistage neoplastic change in B-cell lymphomas induced in the bursa of Fabricius by myc oncogenes...
  37. Genomic Analysis of Gene Copy Number in Thyroid Cancer
    Paul Neiman; Fiscal Year: 2004
    ....
  38. Avian chB6 Alloantigen in Apoptosis
    PHILLIP FUNK; Fiscal Year: 2003
    ..has certain advantages as a model system of this process since B cells are formed in a single organ, the bursa of Fabricius, and many of them are eliminated during their development...