animal mammary glands

Summary

Summary: MAMMARY GLANDS in the non-human MAMMALS.

Top Publications

  1. pmc Candidate regulators of mammary branching morphogenesis identified by genome-wide transcript analysis
    Hosein Kouros-Mehr
    Department of Anatomy, Biomedical Sciences Program, University of California, San Francisco 94143 0452, USA
    Dev Dyn 235:3404-12. 2006
  2. ncbi Gata-3 is an essential regulator of mammary-gland morphogenesis and luminal-cell differentiation
    Marie Liesse Asselin-Labat
    VBCRC Laboratory, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
    Nat Cell Biol 9:201-9. 2007
  3. pmc Expression of the neu protooncogene in the mammary epithelium of transgenic mice induces metastatic disease
    C T Guy
    Institute for Molecular Biology and Biotechnology, McMaster University, Hamilton, Ontario, Canada
    Proc Natl Acad Sci U S A 89:10578-82. 1992
  4. ncbi Stem cells in normal breast development and breast cancer
    Gabriela Dontu
    Department of Internal Medicine, Hematology Oncology, Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA
    Cell Prolif 36:59-72. 2003
  5. ncbi Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome
    R Nusse
    Cell 31:99-109. 1982
  6. ncbi Information networks in the mammary gland
    Lothar Hennighausen
    Laboratory of Genetics and Physiology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Rev Mol Cell Biol 6:715-25. 2005
  7. ncbi Purification and unique properties of mammary epithelial stem cells
    John Stingl
    Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver V5Z 1L3, British Columbia, Canada
    Nature 439:993-7. 2006
  8. ncbi Mammary gland, limb and yolk sac defects in mice lacking Tbx3, the gene mutated in human ulnar mammary syndrome
    Todd G Davenport
    Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, 701 W 168th Street, New York, NY 10032, USA
    Development 130:2263-73. 2003
  9. ncbi The osteoclast differentiation factor osteoprotegerin-ligand is essential for mammary gland development
    J E Fata
    Department of Medical Biophysics, Ontario Cancer Institute, University of Toronto, Canada
    Cell 103:41-50. 2000
  10. ncbi Role of FGF10/FGFR2b signaling during mammary gland development in the mouse embryo
    Arnaud André Mailleux
    UMR144 CNRS Institut Curie, 26 rue d Ulm 75248 Paris Cedex 05, France
    Development 129:53-60. 2002

Research Grants

Detail Information

Publications277 found, 100 shown here

  1. pmc Candidate regulators of mammary branching morphogenesis identified by genome-wide transcript analysis
    Hosein Kouros-Mehr
    Department of Anatomy, Biomedical Sciences Program, University of California, San Francisco 94143 0452, USA
    Dev Dyn 235:3404-12. 2006
    ..We discuss the potential roles of these genes in mammary branching morphogenesis...
  2. ncbi Gata-3 is an essential regulator of mammary-gland morphogenesis and luminal-cell differentiation
    Marie Liesse Asselin-Labat
    VBCRC Laboratory, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
    Nat Cell Biol 9:201-9. 2007
    ..These studies provide evidence for the existence of an epithelial hierarchy within the mammary gland and establish Gata-3 as a critical regulator of luminal differentiation...
  3. pmc Expression of the neu protooncogene in the mammary epithelium of transgenic mice induces metastatic disease
    C T Guy
    Institute for Molecular Biology and Biotechnology, McMaster University, Hamilton, Ontario, Canada
    Proc Natl Acad Sci U S A 89:10578-82. 1992
    ..Interestingly, many of the tumor-bearing transgenic mice developed secondary metastatic tumors in the lung. These observations suggest that overexpression of the unactivated neu protein can induce metastatic disease after long latency...
  4. ncbi Stem cells in normal breast development and breast cancer
    Gabriela Dontu
    Department of Internal Medicine, Hematology Oncology, Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA
    Cell Prolif 36:59-72. 2003
    ..This phenotypic diversity is driven by a small subset of mammary tumour stem cells. We will discuss the important implications of this mammary tumour stem-cell model...
  5. ncbi Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome
    R Nusse
    Cell 31:99-109. 1982
    ..We propose that tumorigenesis by MMTV is strongly favored by proviral insertion within the int1 locus, perhaps as a consequence of enhanced expression of a novel cellular oncogene...
  6. ncbi Information networks in the mammary gland
    Lothar Hennighausen
    Laboratory of Genetics and Physiology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Rev Mol Cell Biol 6:715-25. 2005
    ..Steroids and simple peptide hormones initiate and carry out complex developmental programmes, and reverse genetics has been used to define the underlying mechanistic connections...
  7. ncbi Purification and unique properties of mammary epithelial stem cells
    John Stingl
    Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver V5Z 1L3, British Columbia, Canada
    Nature 439:993-7. 2006
    ..The mammary stem cells are also a rapidly cycling population in the normal adult and have molecular features indicative of a basal position in the mammary epithelium...
  8. ncbi Mammary gland, limb and yolk sac defects in mice lacking Tbx3, the gene mutated in human ulnar mammary syndrome
    Todd G Davenport
    Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, 701 W 168th Street, New York, NY 10032, USA
    Development 130:2263-73. 2003
    ....
  9. ncbi The osteoclast differentiation factor osteoprotegerin-ligand is essential for mammary gland development
    J E Fata
    Department of Medical Biophysics, Ontario Cancer Institute, University of Toronto, Canada
    Cell 103:41-50. 2000
    ..These data provide a novel paradigm in mammary gland development and an evolutionary rationale for hormonal regulation and gender bias of osteoporosis in females...
  10. ncbi Role of FGF10/FGFR2b signaling during mammary gland development in the mouse embryo
    Arnaud André Mailleux
    UMR144 CNRS Institut Curie, 26 rue d Ulm 75248 Paris Cedex 05, France
    Development 129:53-60. 2002
    ..Our results also suggest that FGF signaling is involved in the maintenance of mammary bud 4, and that Fgf10 deficient epithelium can undergo branching morphogenesis into the mammary fat pad precursor...
  11. pmc Stromal effects on mammary gland development and breast cancer
    Bryony S Wiseman
    Department of Anatomy, University of California, 513 Parnassus Avenue, San Francisco, CA 94143, USA
    Science 296:1046-9. 2002
    ..To find cures for diseases like breast cancer that rely on epithelial-stromal crosstalk, we must understand how these different cell types communicate with each other...
  12. ncbi Generation of a functional mammary gland from a single stem cell
    Mark Shackleton
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Nature 439:84-8. 2006
    ..Our data establish that single cells within the Lin-CD29hiCD24+ population are multipotent and self-renewing, properties that define them as MaSCs...
  13. ncbi Stat5a is mandatory for adult mammary gland development and lactogenesis
    X Liu
    Laboratory of Biochemistry and Metabolism, National Institute of Diabetes and Digestive and Kidney Diseases NIDDK, National Institutes of Health NIH, Bethesda, Maryland 20892 1812, USA
    Genes Dev 11:179-86. 1997
    ..These results document that Stat5a is the principal and an obligate mediator of mammopoietic and lactogenic signaling...
  14. pmc Tissue geometry determines sites of mammary branching morphogenesis in organotypic cultures
    Celeste M Nelson
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Science 314:298-300. 2006
    ..These results reveal that tissue geometry can control organ morphogenesis by defining the local cellular microenvironment, a finding that has relevance to control of invasion and metastasis...
  15. ncbi Mammary development in the embryo and adult: a journey of morphogenesis and commitment
    Christine J Watson
    Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK
    Development 135:995-1003. 2008
    ..A surprising recent discovery has been that mammary epithelial cells commit to differentiated lineages using the same signalling pathways that regulate lineage determination in T helper cells...
  16. ncbi Single-step induction of mammary adenocarcinoma in transgenic mice bearing the activated c-neu oncogene
    W J Muller
    Harvard Medical School Department of Genetics, Boston, Massachusetts 02115
    Cell 54:105-15. 1988
    ....
  17. ncbi Notch signaling regulates mammary stem cell function and luminal cell-fate commitment
    Toula Bouras
    VBCRC Laboratory, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
    Cell Stem Cell 3:429-41. 2008
    ..These findings reveal key roles for Notch signaling in MaSCs and luminal cell commitment and further suggest that inappropriate Notch activation promotes the self-renewal and transformation of luminal progenitor cells...
  18. ncbi Mouse embryonic mammogenesis as a model for the molecular regulation of pattern formation
    Jacqueline M Veltmaat
    UMR 144 CNRS Institut Curie, Section de Recherche, Equipe de Morphogenèse Cellulaire et Progression Tumorale, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    Differentiation 71:1-17. 2003
    ..For future investigations in the field, such a unique molecular identity of each mammary rudiment should be of critical concern...
  19. ncbi Bovine TLR2 and TLR4 properly transduce signals from Staphylococcus aureus and E. coli, but S. aureus fails to both activate NF-kappaB in mammary epithelial cells and to quickly induce TNFalpha and interleukin-8 (CXCL8) expression in the udder
    Wei Yang
    Research Institute for the Biology of Farm Animals FBN, Wilhelm Stahl Allee 2, 18196 Dummerstorf, Germany
    Mol Immunol 45:1385-97. 2008
    ..Rather, the pathogen causing subclinical mastitis impairs NF-kappaB activation in MEC thereby severely weakening the immune response in the udder...
  20. ncbi Signaling pathways in mammary gland development
    L Hennighausen
    Laboratory of Genetics and Physiology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 0822, USA
    Dev Cell 1:467-75. 2001
    ..Here we discuss the signaling pathways that have been adopted by the mammary gland for its own purposes, and the functions they perform...
  21. pmc Laminin mediates tissue-specific gene expression in mammary epithelia
    C H Streuli
    School of Biological Sciences, University of Manchester, Zurich
    J Cell Biol 129:591-603. 1995
    ..Our results demonstrate that laminin can direct tissue-specific gene expression in epithelial cells through its globular domain...
  22. pmc The MAPK(ERK-1,2) pathway integrates distinct and antagonistic signals from TGFalpha and FGF7 in morphogenesis of mouse mammary epithelium
    Jimmie E Fata
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Dev Biol 306:193-207. 2007
    ..Our findings indicate that expression of morphogenetic effectors, proliferation, and cell-type decisions during mammary organoid morphogenesis are intimately dependent on the duration of activation of MAPK(ERK1,2) activation...
  23. ncbi Prolactin controls mammary gland development via direct and indirect mechanisms
    C Brisken
    Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02142 1479, USA
    Dev Biol 210:96-106. 1999
    ....
  24. ncbi An adjunct mammary epithelial cell population in parous females: its role in functional adaptation and tissue renewal
    Kay Uwe Wagner
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Rm 8009, Omaha, NE 68198 6805, USA
    Development 129:1377-86. 2002
    ..e. ductal morphogenesis and lobulogenesis). We propose that this parity-induced population contributes importantly to the biological differences between the mammary glands of parous and nulliparous females...
  25. ncbi Transcriptional profiling of mammary gland side population cells
    Fariba Behbod
    Department of Molecular and Cellular Biology, DeBakey Building, M638a, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030 3498, USA
    Stem Cells 24:1065-74. 2006
    ..In conclusion, microarray gene profiling suggests that MG-SPs are a lineage-deficient mammary gland subpopulation expressing key genes involved in cell cycle regulation, development, and angiogenesis...
  26. ncbi Cooperation of signalling pathways in embryonic mammary gland development
    Gertraud W Robinson
    Laboratory of Genetics and Physiology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Building 8, Room 101, 8 Center Drive, Bethesda, Maryland 20892 20822, USA
    Nat Rev Genet 8:963-72. 2007
    ..Some of these signals contribute to aberrant mammary development in humans and are deregulated in cancer...
  27. pmc Neural and mammary gland defects in ErbB4 knockout mice genetically rescued from embryonic lethality
    Hester Tidcombe
    Division of Neurobiology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, United Kingdom
    Proc Natl Acad Sci U S A 100:8281-6. 2003
    ..However, during pregnancy, mammary lobuloalveoli fail to differentiate correctly and lactation is defective. Rescued mice also display aberrant cranial nerve architecture and increased numbers of large interneurons within the cerebellum...
  28. ncbi Peroxisome proliferator-activated receptor-gamma activation and long-chain fatty acids alter lipogenic gene networks in bovine mammary epithelial cells to various extents
    A K G Kadegowda
    Department of Animal and Avian Sciences, University of Maryland, College Park, Maryland 20742, USA
    J Dairy Sci 92:4276-89. 2009
    ..The coordinated upregulation of lipogenic gene networks in response to ROSI and saturated LCFA offers support for PPARG activation in regulating bovine milk fat synthesis...
  29. pmc MET and MYC cooperate in mammary tumorigenesis
    Alana L Welm
    G W Hooper Research Foundation and Department of Microbiology and Immunology, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 102:4324-9. 2005
    ..The approach described here should provide a useful model with which to efficiently test effects of various genes on tumor development in the breast...
  30. pmc PERK-dependent regulation of lipogenesis during mouse mammary gland development and adipocyte differentiation
    Ekaterina Bobrovnikova-Marjon
    The Leonard and Madlyn Abramson Family Cancer Research Institute and Cancer Center, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 105:16314-9. 2008
    ..These findings implicate PERK as a physiologically relevant regulator of the lipogenic pathway...
  31. ncbi p63: a novel myoepithelial cell marker in canine mammary tissues
    A Gama
    Department of Pathology and Veterinary Clinics, University of Trás os Montes e Alro Douro, Vila Real, Portugal
    Vet Pathol 40:412-20. 2003
    ..In conclusion, the present study reveals p63 as a sensitive and highly specific marker of myoepithelial cells in canine mammary tissues, and the authors suggest p63 as an additional marker for defining myoepithelial histogenesis...
  32. ncbi Constitutive activation of smoothened (SMO) in mammary glands of transgenic mice leads to increased proliferation, altered differentiation and ductal dysplasia
    Ricardo C Moraes
    Baylor Breast Center and Department of Molecular and Cellular Biology, Room N1210 MS BCM600, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Development 134:1231-42. 2007
    ..Our data suggest that altered hedgehog signaling may contribute to breast cancer development by stimulating proliferation, and by increasing the pool of division-competent cells capable of anchorage-independent growth...
  33. doi The Pea3 Ets transcription factor regulates differentiation of multipotent progenitor cells during mammary gland development
    Natasza A Kurpios
    Department of Biochemistry and Biomedical Sciences, Centre for Functional Genomics, McMaster University, Hamilton, Ontario, Canada
    Dev Biol 325:106-21. 2009
    ..We propose that Pea3 functions in multipotential progenitors to regulate their lineage-specific differentiation potential...
  34. ncbi RANK-L and RANK: T cells, bone loss, and mammalian evolution
    Lars E Theill
    Inflammation Drug Discovery Research, One Amgen Center Drive, Thousand Oaks, California 91320 1789, USA
    Annu Rev Immunol 20:795-823. 2002
    ..Modulation of these systems provides us with a unique opportunity to design novel therapeutics to inhibit bone loss in arthritis, periodontal disease, and osteoporosis...
  35. ncbi Comparison of steroid receptor expression in normal, dysplastic, and neoplastic canine and feline mammary tissues
    F Millanta
    Department of Animal Pathology, School of Veterinary Medicine, University of Pisa, Viale delle Piagge, 2, I 56124 Pisa, Italy
    Res Vet Sci 79:225-32. 2005
    ..The low percentage of ER-positive invasive carcinomas further demonstrated the aggressive phenotype and behaviour of feline mammary tumours...
  36. ncbi Persistent changes in gene expression induced by estrogen and progesterone in the rat mammary gland
    M R Ginger
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030 3411, USA
    Mol Endocrinol 15:1993-2009. 2001
    ..These results provide the first support at the molecular level for the hypothesis that hormone-induced persistent changes in gene expression are present in the involuted mammary gland...
  37. pmc Interactions between FGF and Wnt signals and Tbx3 gene expression in mammary gland initiation in mouse embryos
    Maxwell C Eblaghie
    Division of Cell and Developmental Biology, Faculty of Life Sciences, Wellcome Trust Biocentre, University of Dundee, Scotland, UK
    J Anat 205:1-13. 2004
    ..These data, taken together with previous findings, suggest a model in which Tbx3 expression is induced and maintained in early gland initiation by both Wnt and Fgf signalling through FGFR1...
  38. ncbi WNT signals are required for the initiation of hair follicle development
    Thomas Andl
    Department of Dermatology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Dev Cell 2:643-53. 2002
    ..This phenotype indicates that activation of WNT signaling in the skin precedes, and is required for, localized expression of regulatory genes and initiation of hair follicle placode formation...
  39. ncbi Lipopolysaccharide and lipoteichoic acid induce different innate immune responses in bovine mammary epithelial cells
    Ylva Strandberg
    CSIRO Livestock Industries, Queensland Bioscience Precinct, 306 Carmody Road, St Lucia 4067, QLD, Australia
    Cytokine 31:72-86. 2005
    ..It was concluded that bovine mammary epithelial cells have a strong but differential capacity to mount innate immune responses to bacterial cell wall components...
  40. pmc RANK overexpression in transgenic mice with mouse mammary tumor virus promoter-controlled RANK increases proliferation and impairs alveolar differentiation in the mammary epithelia and disrupts lumen formation in cultured epithelial acini
    Eva Gonzalez-Suarez
    Department of Cancer Biology, AW2 D2262, Amgen Inc, 1201 Amgen Court West, Seattle, WA 98119, USA
    Mol Cell Biol 27:1442-54. 2007
    ..Moreover, the increased proliferation and survival observed in a three-dimensional culture system suggests a role for aberrant RANK signaling during breast tumorigenesis...
  41. pmc Defective mammary gland morphogenesis in mice lacking the progesterone receptor B isoform
    Biserka Mulac-Jericevic
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 100:9744-9. 2003
    ....
  42. ncbi Invasive potential induced under long-term oxidative stress in mammary epithelial cells
    Kazunori Mori
    Department of Microbiology, Showa University School of Pharmaceutical Sciences, Tokyo, Japan
    Cancer Res 64:7464-72. 2004
    ....
  43. ncbi A developmental atlas of rat mammary gland histology
    P A Masso-Welch
    Roswell Park Cancer Institute, Buffalo, New York, USA
    J Mammary Gland Biol Neoplasia 5:165-85. 2000
    ..The purpose of this review is to assist researchers in recognizing histological changes in the epithelium and stroma of the rat mammary gland throughout development...
  44. pmc The housekeeping gene xanthine oxidoreductase is necessary for milk fat droplet enveloping and secretion: gene sharing in the lactating mammary gland
    Claudia Vorbach
    Howard Hughes Medical Institute, Department of Human Genetics, University of Utah, Salt Lake City 84112, USA
    Genes Dev 16:3223-35. 2002
    ..About 5% of women experience primary lactation insufficiency. The above observations suggest that human females suffering from xanthinuria, a deficiency in XOR, are potential candidates for lactation problems...
  45. pmc WNT/beta-catenin mediates radiation resistance of mouse mammary progenitor cells
    Wendy A Woodward
    Department of Radiation Oncology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 104:618-23. 2007
    ..These data demonstrate that, compared with differentiated cells, progenitor cells have different cell survival properties that may facilitate the development of targeted antiprogenitor cell therapies...
  46. ncbi Differential mammary morphogenesis along the anteroposterior axis in Hoxc6 gene targeted mice
    A Garcia-Gasca
    Center for Molecular and Structural Biology, Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina 29403, USA
    Dev Dyn 219:261-76. 2000
    ..The position-specific phenotypes observed and the potential role for Hoxc6 in mediating hormone-regulated ductal expansion and regression in the adult female are discussed...
  47. ncbi Progesterone signaling and mammary gland morphogenesis
    G Shyamala
    Division of Life Sciences, Lawrence Berkeley National Laboratory, University of California, Berkeley 94720, USA
    J Mammary Gland Biol Neoplasia 4:89-104. 1999
    ....
  48. ncbi Epithelial development and differentiation in the mammary gland is not dependent on alpha 3 or alpha 6 integrin subunits
    T C Klinowska
    School of Biological Sciences, University of Manchester, 3 239 Stopford Building, Oxford Road, Manchester, M13 9PT, United Kingdom
    Dev Biol 233:449-67. 2001
    ..This work demonstrates that mammary tissue genetically lacking major laminin-binding integrin receptors is still able to develop and function...
  49. ncbi Reducing mammary cancer risk through premature stem cell senescence
    C A Boulanger
    Laboratory of Tumor Immunology and Biology, National Cancer Institute, Bethesda, Maryland, MD 20892, USA
    Oncogene 20:2264-72. 2001
    ..The results suggest a positive correlation between the procreative life-span of mammary epithelial stem cells and mammary cancer risk...
  50. ncbi Expression of a truncated Brca1 protein delays lactational mammary development in transgenic mice
    Melissa A Brown
    Department of Medical and Molecular Genetics, King s College London, Guy s Hospital, UK
    Transgenic Res 11:467-78. 2002
    ..They may also have implications for germline carriers of BRCA1 mutations...
  51. ncbi Insulin-like growth factor-II regulates PTEN expression in the mammary gland
    Roger A Moorehead
    Ontario Cancer Institute University Health Network, University of Toronto, Toronto, Ontario M5G 2M9, Canada
    J Biol Chem 278:50422-7. 2003
    ..Thus, we have identified a novel negative feedback loop within the PI3K pathway where IGF-II induces PTEN expression to modulate its physiologic effects...
  52. ncbi Genetic manipulation of mammary epithelium by transplantation
    P A Edwards
    Department of Pathology, University of Cambridge, U K
    J Mammary Gland Biol Neoplasia 1:75-89. 1996
    ..Insights into normal development have also been obtained by inappropriate expression of genes such as Wnt-4...
  53. pmc Cattle mammary bioreactor generated by a novel procedure of transgenic cloning for large-scale production of functional human lactoferrin
    Penghua Yang
    State Key Laboratory for Agrobiotechnology, China Agricultural University, Beijing, People s Republic of China
    PLoS ONE 3:e3453. 2008
    ..Moreover, the cattle mammary bioreactors generated with this novel procedure produce functional rhLF on an industrial scale...
  54. ncbi Parathyroid hormone-related protein maintains mammary epithelial fate and triggers nipple skin differentiation during embryonic breast development
    J Foley
    Medical Sciences, Indiana University School of Medicine, Bloomington, IN 47405, USA
    Development 128:513-25. 2001
    ..Finally, PTHrP signaling regulates the epidermal and mesenchymal expression of LEF1 and (&bgr;)-catenin, suggesting that these changes in cell fate involve an interaction between the PTHrP and Wnt signaling pathways...
  55. ncbi Innate immune response to intramammary infection with Serratia marcescens and Streptococcus uberis
    Douglas D Bannerman
    Bovine Functional Genomics Laboratory, Beltsville Agricultural Research Center, USDA Agricultural Research Service, Beltsville, MD 20705, USA
    Vet Res 35:681-700. 2004
    ..marcescens infection. Together, these data demonstrate the variability of the innate immune response to two distinct mastitis pathogens...
  56. ncbi Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation
    X Xu
    Genetics of Development and Disease Branch, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Genet 22:37-43. 1999
    ..Our results demonstrate that disruption of Brca1 causes genetic instability and triggers further alterations, including the inactivation of p53, that lead to tumour formation...
  57. ncbi Next stop, the twilight zone: hedgehog network regulation of mammary gland development
    Michael T Lewis
    Baylor College of Medicine, Houston, Texas 77030, USA
    J Mammary Gland Biol Neoplasia 9:165-81. 2004
    ..Further, studies suggest a role for misregulated network function in the progression of breast cancer...
  58. ncbi Bacterial lipopolysaccharide induces increased expression of toll-like receptor (TLR) 4 and downstream TLR signaling molecules in bovine mammary epithelial cells
    Eveline M Ibeagha-Awemu
    Department of Animal Science, McGill University, 21111 Lakeshore Road, Ste Anne de Bellevue, Quebec, H9X 3V9 Canada
    Vet Res 39:11. 2008
    ..The current findings, coupled with previous findings that S. aureus ligands induce up-regulation of TLR4, may indicate a positive adaptation by mammary epithelial cells to effectively respond to different types of mastitis pathogens...
  59. doi Escherichia coli, but not Staphylococcus aureus triggers an early increased expression of factors contributing to the innate immune defense in the udder of the cow
    Wolfram Petzl
    Clinic for Ruminants, Ludwig Maximilians University, Munich, Germany
    Vet Res 39:18. 2008
    ..Using the established mastitis model, the data clearly demonstrate a pathogen-dependent difference in the time kinetics of induced pathogen receptors and defense molecules...
  60. pmc Collagen reorganization at the tumor-stromal interface facilitates local invasion
    Paolo P Provenzano
    Department of Pharmacology, University of Wisconsin, Madison, WI, USA
    BMC Med 4:38. 2006
    ....
  61. ncbi Targeted disruption of beta1-integrin in a transgenic mouse model of human breast cancer reveals an essential role in mammary tumor induction
    Donald E White
    Department of Medical Sciences, McMaster University, Hamilton, Ontario, L8S 4K1, Canada
    Cancer Cell 6:159-70. 2004
    ..These observations provide a direct demonstration that beta1-integrin plays a critical role in both the initiation and maintenance of mammary tumor growth in vivo...
  62. pmc Self-organization of engineered epithelial tubules by differential cellular motility
    Hidetoshi Mori
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 106:14890-5. 2009
    ..These results indicate that differential directional persistence can give rise to patterns within model developing tissues...
  63. pmc Signalling pathways implicated in early mammary gland morphogenesis and breast cancer
    Beatrice Howard
    University College London, United Kingdom
    PLoS Genet 2:e112. 2006
    ..Reflecting this intimate connection, a considerable number of signalling pathways have been implicated in both mammary gland morphogenesis and carcinogenesis...
  64. ncbi Cadherins and the mammary gland
    Karen A Knudsen
    Lankenau Institute for Medical Research, Wynnewood, PA 19096, USA
    J Cell Biochem 95:488-96. 2005
    ..Additional research is needed to more precisely define the roles of both classical and desmosomal cadherins and their downstream signaling events, in the development and malignant behavior of breast cancers...
  65. ncbi Mammary gland development in adult mice requires epithelial and stromal estrogen receptor alpha
    Stefan O Mueller
    Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Endocrinology 143:2357-65. 2002
    ..Immunostaining for ER alpha and PR in the mammary outgrowths supported the view that both stromal and epithelial ER alpha, in cooperation with epithelial PR, govern mammary gland development in adult mice...
  66. ncbi A whole-genome scan for quantitative trait loci affecting teat number in pigs
    H Hirooka
    Faculty of Economics, Ryukoku University, Kyoto, Japan
    J Anim Sci 79:2320-6. 2001
    ..This study shows that imprinting may play an important role in the expression of teat number...
  67. ncbi Transport of milk constituents by the mammary gland
    D B Shennan
    Hannah Research Institute, Ayr, Scotland
    Physiol Rev 80:925-51. 2000
    ....
  68. ncbi Spontaneous feline mammary carcinoma is a model of HER2 overexpressing poor prognosis human breast cancer
    Raffaella De Maria
    Department of Animal Pathology, School of Veterinary Medicine, University of Turin, Grugliasco, Turin, Italy
    Cancer Res 65:907-12. 2005
    ....
  69. ncbi Establishing a framework for the functional mammary gland: from endocrinology to morphology
    Russell C Hovey
    Molecular and Cellular Endocrinology Section, Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 1402, USA
    J Mammary Gland Biol Neoplasia 7:17-38. 2002
    ..Defining the hormonal control of ductal development should facilitate a better understanding of the mechanisms underlying mammary gland tumorigenesis...
  70. pmc Key stages of mammary gland development: molecular mechanisms involved in the formation of the embryonic mammary gland
    Julie R Hens
    Section of Endocrinology and Metabolism, Department of Internal Medicine, Yale University School of Medicine, and Anlyan Center for Medical Research and Education, New Haven, Connecticut, USA
    Breast Cancer Res 7:220-4. 2005
    ..This review describes what is known about the molecular mechanisms that regulate embryonic mammary gland development...
  71. pmc Stromelysin-1 and mesothelin are differentially regulated by Wnt-5a and Wnt-1 in C57mg mouse mammary epithelial cells
    Mary G Prieve
    Department of Pharmacology, Howard Hughes Medical Institute, and Center for Developmental Biology, University of Washington School of Medicine, Seattle, WA 98195, USA
    BMC Dev Biol 3:2. 2003
    ..Many downstream target genes of the Wnt/beta-catenin pathway have been identified. In contrast, little is known about the Wnt/Ca2+ pathway and whether it regulates gene expression...
  72. pmc The steroid receptor coactivator SRC-3 (p/CIP/RAC3/AIB1/ACTR/TRAM-1) is required for normal growth, puberty, female reproductive function, and mammary gland development
    J Xu
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 97:6379-84. 2000
    ..These results suggest that the physiological role of SRC-3 is different from that of SRC-1 and prove the diversity among coactivator family members...
  73. pmc Minireview: hormones and mammary cell fate--what will I become when I grow up?
    Heather L LaMarca
    Department of Molecular and Cellular Biology, DeBakey Building M638a, Houston, Texas 77030, USA
    Endocrinology 149:4317-21. 2008
    ..Here we review recent studies on the involvement of hormone receptors and several transcription factors in mammary stem/progenitor cell differentiation and lineage commitment...
  74. pmc Activated Abl kinase inhibits oncogenic transforming growth factor-beta signaling and tumorigenesis in mammary tumors
    Tressa M Allington
    Department of Pharmacology, MS 8303, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO 80045, USA
    FASEB J 23:4231-43. 2009
    ..Notably, our findings strongly caution against the use of pharmacological Abl antagonists in the treatment of developing and progressing mammary tumors...
  75. pmc Collective epithelial migration and cell rearrangements drive mammary branching morphogenesis
    Andrew J Ewald
    Department of Anatomy and Program in Cell Biology, University of California, San Francisco, San Francisco, CA 94143, USA
    Dev Cell 14:570-81. 2008
    ..Significantly, we observed that normal epithelium and neoplastic hyperplasias are organized similarly, suggesting common mechanisms of epithelial growth...
  76. ncbi Vitamin D receptor (VDR) ablation alters carcinogen-induced tumorigenesis in mammary gland, epidermis and lymphoid tissues
    Glendon M Zinser
    Department of Biological Sciences, University of Notre Dame, 214 Galvin Life Sciences Building, Notre Dame, IN 46556, USA
    J Steroid Biochem Mol Biol 97:153-64. 2005
    ..These data indicate that VDR ablation alters susceptibility to DMBA-induced carcinogenesis in a tissue specific fashion, and provide support that optimal VDR signaling may act to suppress tumorigenesis...
  77. ncbi Protein kinase CK2 in mammary gland tumorigenesis
    E Landesman-Bollag
    Department of Medicine, Boston Medical Center, Boston, Massachusetts, MA 02118 2394, USA
    Oncogene 20:3247-57. 2001
    ..Thus, in mice, rats, and humans, dysregulated expression of CK2 is associated with and is capable of contributing to mammary tumorigenesis. Targeted inhibition of CK2 could be useful in the treatment of breast cancer...
  78. ncbi A novel effect of dioxin: exposure during pregnancy severely impairs mammary gland differentiation
    Beth A Vorderstrasse
    Department of Pharmaceutical Sciences, Washington State University, Pullman, Washington 99164, USA
    Toxicol Sci 78:248-57. 2004
    ....
  79. pmc Gene expression profiling of mammary gland development reveals putative roles for death receptors and immune mediators in post-lactational regression
    Richard W E Clarkson
    Department of Pathology, University of Cambridge, Cambridge, UK
    Breast Cancer Res 6:R92-109. 2004
    ....
  80. ncbi Mammary involution in dairy animals
    A V Capuco
    Gene Evaluation and Mapping Laboratory, USDA ARS, Beltsville, Maryland 20705, USA
    J Mammary Gland Biol Neoplasia 4:137-44. 1999
    ..The ability to manipulate apoptosis and cell proliferation during the nonlactating period and during lactation is expected to provide enormous benefits to the dairy industry...
  81. pmc Insulin-mediated acceleration of breast cancer development and progression in a nonobese model of type 2 diabetes
    Ruslan Novosyadlyy
    Division of Endocrinology, Diabetes and Bone Diseases, The Samuel Bronfman Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Cancer Res 70:741-51. 2010
    ..Our findings offer compelling experimental evidence that T2D accelerates mammary gland development and carcinogenesis,and that the IR and/or the IGF-IR are major mediators of these effects...
  82. ncbi Parathyroid hormone-related protein signaling is necessary for sexual dimorphism during embryonic mammary development
    M E Dunbar
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520 8020, USA
    Development 126:3485-93. 1999
    ..We propose that PTHrP expression specifically within the developing epithelial bud acts as a dominant signal participating in cell fate decisions leading to a specialized mammary mesenchyme...
  83. pmc Functional culture models to study mechanisms governing apoptosis in normal and malignant mammary epithelial cells
    V M Weaver
    Life Sciences Division, Lawrence Berkeley National Laboratory, University of California, Berkeley 94720, USA
    J Mammary Gland Biol Neoplasia 4:193-201. 1999
    ..These models could now be used to investigate how the basement membrane represses apoptosis in normal cells, and how breast cancers become death-resistant...
  84. ncbi Tbx3, the ulnar-mammary syndrome gene, and Tbx2 interact in mammary gland development through a p19Arf/p53-independent pathway
    Loydie A Jerome-Majewska
    Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Dev Dyn 234:922-33. 2005
    ....
  85. ncbi Tumour necrosis factor-alpha (TNF-alpha) increases nuclear factor kappaB (NFkappaB) activity in and interleukin-8 (IL-8) release from bovine mammary epithelial cells
    D C Fitzgerald
    UCD School of Agriculture, Food Science and Veterinary Medicine, University College Dublin, Belfield, Dublin 4, Ireland
    Vet Immunol Immunopathol 116:59-68. 2007
    ..These data support a role for TNF-alpha in activation of NFkappaB and release of IL-8 from bovine mammary epithelial cells...
  86. pmc Development of mammary luminal progenitor cells is controlled by the transcription factor STAT5A
    Daisuke Yamaji
    Laboratory of Genetics and Physiology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Genes Dev 23:2382-7. 2009
    ..Thus, STAT5A is necessary and sufficient for the establishment of luminal progenitor cells...
  87. pmc Regulation of mammary gland branching morphogenesis by EphA2 receptor tyrosine kinase
    David Vaught
    Department of Cancer Biology, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Mol Biol Cell 20:2572-81. 2009
    ..Together, these data demonstrate a positive role for EphA2 during normal mammary epithelial proliferation and branching morphogenesis...
  88. ncbi Adhesion-mediated signaling in the regulation of mammary epithelial cell survival
    C H Streuli
    School of Biological Sciences, University of Manchester, United Kingdom
    J Mammary Gland Biol Neoplasia 4:183-91. 1999
    ..In this review we consider the molecular mechanisms by which cell-matrix interactions contribute to cell survival, and discuss their role in mammary gland development and function...
  89. ncbi C/EBPbeta (CCAAT/enhancer binding protein) controls cell fate determination during mammary gland development
    T N Seagroves
    Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030 3498, USA
    Mol Endocrinol 14:359-68. 2000
    ....
  90. pmc Matrix metalloproteinases and the regulation of tissue remodelling
    Andrea Page-McCaw
    Department of Biology and Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, New York 12180, USA
    Nat Rev Mol Cell Biol 8:221-33. 2007
    ..Recent studies in mice and flies point to essential roles of MMPs as mediators of change and physical adaptation in tissues, whether developmentally regulated, environmentally induced or disease associated...
  91. pmc Lactation defect in mice lacking the helix-loop-helix inhibitor Id2
    S Mori
    Department of Molecular Genetics, Kyoto University Graduate School of Medicine, Shogoin Kawahara cho 53, Sakyo ku, Kyoto 606 8507, Japan
    EMBO J 19:5772-81. 2000
    ..A decrease in the DNA binding activity of Stat5 was also observed in Id2(-/-) mammary glands at 7 days post-coitus. Our results indicate an indispensable role of Id2 in pregnant mammary glands...
  92. ncbi The mouse mammary gland requires the actin-binding protein gelsolin for proper ductal morphogenesis
    M R Crowley
    Division of Experimental Pathology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, New York 14263, USA
    Dev Biol 225:407-23. 2000
    ..Our results provide the first evidence of an actin regulatory protein affecting mammary ductal growth through stromal-epithelial communication...
  93. ncbi TNFalpha induces NFkappaB/p50 in association with the growth and morphogenesis of normal and transformed rat mammary epithelial cells
    L M Varela
    Department of Pharmacology and Therapeutics, Grace Cancer Drug Center, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    J Cell Physiol 188:120-31. 2001
    ..In addition, the significant increase in NFkappaB/p50 DNA-binding was temporally coincident with TNFalpha-induced growth and morphogenesis, suggesting that it may play a significant role in both normal development and carcinogenesis...
  94. ncbi Src activation is not necessary for transforming growth factor (TGF)-beta-mediated epithelial to mesenchymal transitions (EMT) in mammary epithelial cells. PP1 directly inhibits TGF-beta receptors I and II
    Masato Maeda
    Department of Oral Biology, College of Dentistry, University of Nebraska Medical Center, Nebraska Medical Center, Omaha 68198 7696, USA
    J Biol Chem 281:59-68. 2006
    ..Taken together, our data indicated that PP1 interferes with TGF-beta1-mediated EMT not by inhibiting Src family kinases but by inhibiting the Smad pathway via a direct inhibition of TGF-beta receptor kinase activity...
  95. ncbi Lipid synthesis in lactation: diet and the fatty acid switch
    Michael C Rudolph
    Department of Pathology, University of Colorado Health Sciences Center, Anschutz Medical Campus, 12801 East 17th Avenue, Mail Stop 8104, P O Box 6511, Aurora, CO 80045, USA
    J Mammary Gland Biol Neoplasia 12:269-81. 2007
    ..These regulatory pathways may be critical to the production of milk with a balanced TAG composition to support neonatal development of the newborn...
  96. ncbi Activated type I TGFbeta receptor kinase enhances the survival of mammary epithelial cells and accelerates tumor progression
    R S Muraoka-Cook
    Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN 37232 6307, USA
    Oncogene 25:3408-23. 2006
    ....
  97. ncbi The spatial and temporal expression of the alpha 2 beta 1 integrin and its ligands, collagen I, collagen IV, and laminin, suggest important roles in mouse mammary morphogenesis
    P J Keely
    Department of Pathology, Washington University School of Medicine, St Louis, MO 63110 1093, USA
    Differentiation 59:1-13. 1995
    ..Our results suggest that alpha 2 beta 1 integrin interactions with its temporally and spatially regulated ligands, collagen I, collagen IV, and laminin, could play an important role in mammary morphogenesis in vivo...
  98. pmc Identification of immune genes and proteins involved in the response of bovine mammary tissue to Staphylococcus aureus infection
    Ylva C Strandberg Lutzow
    Co operative Research Centre for Innovative Dairy Products, Australia
    BMC Vet Res 4:18. 2008
    ..Moreover, the effect of infection on the presence of bioactive innate immune proteins in milk is also unclear. The nature of these responses may determine the susceptibility of the tissue and its ability to resolve the infection...
  99. ncbi Colony stimulating factor-1 is required to recruit macrophages into the mammary gland to facilitate mammary ductal outgrowth
    Andrew Van Nguyen
    Department of Developmental and Molecular Biology, Center for the Study of Reproductive Biology and Women s Health, Albert Einstein College of Medicine, 1300 Morris Park, New York, New York, 10461, USA
    Dev Biol 247:11-25. 2002
    ..These data show that macrophages acting locally are required for branching morphogenesis of the mammary gland...
  100. ncbi Clinical parameters for assessment of udder health in Danish dairy herds
    H Houe
    Department of Animal Science and Animal Health, The Royal Veterinary and Agricultural University, Frederiksberg, Denmark
    Acta Vet Scand 43:173-84. 2002
    ..It is further concluded that certain combinations of extended clinical recordings have significant perspectives for future characterisation of udder health...
  101. ncbi Shh expression is required for embryonic hair follicle but not mammary gland development
    Kinga Michno
    Department of Laboratory Medicine, University of Toronto, Toronto, Ontario, Canada
    Dev Biol 264:153-65. 2003
    ..Furthermore, these data suggest that cyclin D1 expression in the embryonic hair follicle is mediated by both Hh-independent and Hh-dependent mechanisms...

Research Grants156 found, 100 shown here

  1. MTA1 IN ONCOGENESIS
    Rakesh Kumar; Fiscal Year: 2010
    ..The proposal is designed to establish the mechanism by which MTA1 contributes to the development of tumorigenic phenotypes in mammary epithelial cells and tumors. ..
  2. Progestin Actions in the Primate Breast and Uterus
    Charles Wood; Fiscal Year: 2008
    ..This work will have immediate public health relevance to postmenopausal women seeking the safest form of hormone therapy. ..
  3. Progestin Actions in the Primate Breast and Uterus
    Charles Wood; Fiscal Year: 2007
    ..This work will have immediate public health relevance to postmenopausal women seeking the safest form of hormone therapy. ..
  4. IGF-1 Receptor Signaling in Mammary Gland Development
    Darryl Hadsell; Fiscal Year: 2004
    ..abstract_text> ..
  5. IGF-1 Receptor Signaling in Mammary Gland Development
    Darryl Hadsell; Fiscal Year: 2006
    ..abstract_text> ..
  6. IGF-1 Receptor Signaling in Mammary Gland Development
    Darryl Hadsell; Fiscal Year: 2003
    ..abstract_text> ..
  7. IGF-1 Receptor Signaling in Mammary Gland Development
    Darryl Hadsell; Fiscal Year: 2005
    ..abstract_text> ..
  8. Breast Cancer and the Environment Research Center
    SANDRA HASLAM; Fiscal Year: 2007
    ..abstract_text> ..
  9. BIOLOGY OF NEOPLASTIC TRANSFORMATION IN BREAST CANCER
    Robert Cardiff; Fiscal Year: 2005
    ..The goal of this project is to develop a well-characterized model for breast cancer development and to dissect the molecular pathways involved in tumor formation. ..
  10. BIOLOGY OF NEOPLASTIC TRANSFORMATION IN BREAST CANCER
    Robert Cardiff; Fiscal Year: 2001
    ..The goal of this project is to develop a well-characterized model for breast cancer development and to dissect the molecular pathways involved in tumor formation. ..
  11. Breast Cancer and the Environment Research Center
    SANDRA HASLAM; Fiscal Year: 2008
    ..abstract_text> ..
  12. STROMA AND MAMMARY GLAND CELL PROLIFERATION
    SANDRA HASLAM; Fiscal Year: 2000
    ....
  13. P53 AND MOUSE MAMMARY TUMORIGENESIS
    Daniel Medina; Fiscal Year: 2000
    ..In summary, this model allows one to analyze the biological, genetic and molecular consequences of p53 gene deletion in the in situ mammary gland by taking advantage of transplantation methods. ..
  14. P53 AND MOUSE MAMMARY TUMORIGENESIS
    Daniel Medina; Fiscal Year: 2002
    ..In summary, this model allows one to analyze the biological, genetic and molecular consequences of p53 gene deletion in the in situ mammary gland by taking advantage of transplantation methods. ..
  15. MECHANISMS OF THE HORMONAL PREVENTION OF BREAST CANCER
    Daniel Medina; Fiscal Year: 2006
    ..The molecular understanding of the fundamental biological events involved in hormone-induced growth and differentiation will provide a rationale for developing new approaches for preventing human breast cancer. ..
  16. ROLE OF STROMA IN MAMMARY GLAND CELL PROLIFERATION
    SANDRA HASLAM; Fiscal Year: 2005
    ..The long-term goal of this proposal is the delineation of the mechanisms of P-dependent growth regulation in the adult normal mammary gland that may lead to novel strategies for the prevention and treatment of breast cancer. ..
  17. ROLE OF STROMA IN MAMMARY GLAND CELL PROLIFERATION
    SANDRA HASLAM; Fiscal Year: 2004
    ..The long-term goal of this proposal is the delineation of the mechanisms of P-dependent growth regulation in the adult normal mammary gland that may lead to novel strategies for the prevention and treatment of breast cancer. ..
  18. PRECLINICAL MODELS OF BREAST CANCER
    Robert Cardiff; Fiscal Year: 2003
    ..The theme of the workshop is "High Throughput Phenotyping: From Mouse to Molecule in One Day!" It will allow the student to examine and compare the best and fastest phenotyping technology currently available. ..
  19. BIOLOGY OF NEOPLASTIC TRANSFORMATION IN BREAST CANCER
    Robert Cardiff; Fiscal Year: 2003
    ..The goal of this project is to develop a well-characterized model for breast cancer development and to dissect the molecular pathways involved in tumor formation. ..
  20. BIOLOGY OF NEOPLASTIC TRANSFORMATION IN BREAST CANCER
    Robert Cardiff; Fiscal Year: 2004
    ..The goal of this project is to develop a well-characterized model for breast cancer development and to dissect the molecular pathways involved in tumor formation. ..
  21. P53 AND MOUSE MAMMARY TUMORIGENESIS
    Daniel Medina; Fiscal Year: 2004
    ..In summary, this model allows one to analyze the biological, genetic and molecular consequences of p53 gene deletion in the in situ mammary gland by taking advantage of transplantation methods. ..
  22. ROLE OF STROMA IN MAMMARY GLAND CELL PROLIFERATION
    SANDRA HASLAM; Fiscal Year: 2003
    ..The long-term goal of this proposal is the delineation of the mechanisms of P-dependent growth regulation in the adult normal mammary gland that may lead to novel strategies for the prevention and treatment of breast cancer. ..
  23. ROLE OF STROMA IN MAMMARY GLAND CELL PROLIFERATION
    SANDRA HASLAM; Fiscal Year: 2006
    ..The long-term goal of this proposal is the delineation of the mechanisms of P-dependent growth regulation in the adult normal mammary gland that may lead to novel strategies for the prevention and treatment of breast cancer. ..
  24. GORDON RESEARCH CONFERENCE ON MAMMARY GLAND BIOLOGY
    MARY BARCELLOS HOFF; Fiscal Year: 2003
    ..abstract_text> ..
  25. P53 AND MOUSE MAMMARY TUMORIGENESIS
    Daniel Medina; Fiscal Year: 2003
    ..In summary, this model allows one to analyze the biological, genetic and molecular consequences of p53 gene deletion in the in situ mammary gland by taking advantage of transplantation methods. ..
  26. 25TH IABCR CONGRESS CONFERENCE: PERSONALIZED BREAST CANCER THERAPY
    Robert Cardiff; Fiscal Year: 2006
    ..The session will also include a plenary lecture from Dr. A Ullrich who pioneered the concept of targeting the HER2 oncogene in the treatment of breast cancer. [unreadable] [unreadable] [unreadable] [unreadable]..
  27. ROLE OF STROMA IN MAMMARY GLAND CELL PROLIFERATION
    SANDRA HASLAM; Fiscal Year: 2007
    ..The long-term goal of this proposal is the delineation of the mechanisms of P-dependent growth regulation in the adult normal mammary gland that may lead to novel strategies for the prevention and treatment of breast cancer. ..
  28. SELENIUM AND MAMMARY TUMORIGENESIS
    Daniel Medina; Fiscal Year: 1993
    ....
  29. SELENIUM AND MAMMARY TUMORIGENESIS
    Daniel Medina; Fiscal Year: 1992
    ....
  30. STROMA AND MAMMARY GLAND CELL PROLIFERATION
    SANDRA HASLAM; Fiscal Year: 1999
    ....
  31. BIOLOGY OF MOUSE MAMMARY PRENEOPLASIAS
    Daniel Medina; Fiscal Year: 1990
    ..The hypothesis that the chemopreventive effects of selenium on cell growth are mediated by modification of protein function will be pursued by examining protein phosphorylation and protein synthesis...
  32. ROLE OF STROMA IN MAMMARY GLAND CELL PROLIFERATION
    SANDRA HASLAM; Fiscal Year: 1990
    ..The long term goal of these studies is to elucidate the biological basis of hormone independence and provide a rationale for treatment of hormone independent human mammary cancer...
  33. ROLE OF STROMA IN MAMMARY GLAND CELL PROLIFERATION
    SANDRA HASLAM; Fiscal Year: 1991
    ..The long term goal of these studies is to elucidate the biological basis of hormone independence and provide a rationale for treatment of hormone independent human mammary cancer...
  34. STROMA AND MAMMARY GLAND CELL PROLIFERATION
    SANDRA HASLAM; Fiscal Year: 1993
    ....
  35. ROLE OF STROMA IN MAMMARY GLAND CELL PROLIFERATION
    SANDRA HASLAM; Fiscal Year: 1992
    ..The long term goal of these studies is to elucidate the biological basis of hormone independence and provide a rationale for treatment of hormone independent human mammary cancer...
  36. NuMA function in nonmalignant and malignant breast cells
    SOPHIE LELIEVRE; Fiscal Year: 2009
    ..Thus, it is time to emphasize the role of structural nuclear proteins in gene transcription in order to get a complete picture of gene expression control. ..
  37. HER2 Pathway in Breast Cancer Progression and Treatment
    Rakesh Kumar; Fiscal Year: 2006
    ..abstract_text> ..
  38. Regulation of Cellular Zn Redistribution: A Role of ZnT2
    Shannon L Kelleher; Fiscal Year: 2010
    ..Thus, this application has significance for improving public health outcomes and advancing our understanding of basic cellular mechanisms. ..
  39. Role of Metastatic Tumor Antigen-1 in Mammary Gland
    Rakesh Kumar; Fiscal Year: 2006
    ..abstract_text> ..
  40. NuMA function in nonmalignant and malignant breast cells
    SOPHIE A LELIEVRE; Fiscal Year: 2010
    ..Thus, it is time to emphasize the role of structural nuclear proteins in gene transcription in order to get a complete picture of gene expression control. ..
  41. Regulation of Cellular Zn Redistribution: A Role of ZnT2
    Shannon L Kelleher; Fiscal Year: 2010
    ..Thus, this application has significance for improving public health outcomes and advancing our understanding of basic cellular mechanisms. ..
  42. Small Laboratory Animal Imaging: High Resolution Microcomputed Tomography System
    RAMIRO TORIBIO; Fiscal Year: 2006
    ..Salary and benefits for the Supervisor and Space and utilities for the instrument will be provided by Department of Veterinary Biosciences and the College of Veterinary Medicine. [unreadable] [unreadable]..
  43. Pak1 - PIN Pathway in Breast Cancer Progression
    Rakesh Kumar; Fiscal Year: 2005
    ..Our proposed research is significant as this research might form the basis for new advances in identifying novel molecular targets, detecting, preventing and treating breast cancer, by identifying PIN as a key regulatory nodule. ..
  44. Role of Metastatic Tumor Antigen-1 in Mammary Gland
    Rakesh Kumar; Fiscal Year: 2005
    ..abstract_text> ..
  45. SERM Regulation of PAK Pathway in Endometrial Cancer
    Rakesh Kumar; Fiscal Year: 2005
    ..abstract_text> ..
  46. Pak1 and Hormone Response in Breast Cancer Progression
    Rakesh Kumar; Fiscal Year: 2005
    ..This research is significant in that the knowledge gained from this research will enhance our understanding of the critical regulatory pathways with established roles in breast cancer progression. ..
  47. Pak1 - PIN Pathway in Breast Cancer Progression
    Rakesh Kumar; Fiscal Year: 2006
    ..Our proposed research is significant as this research might form the basis for new advances in identifying novel molecular targets, detecting, preventing and treating breast cancer, by identifying PIN as a key regulatory nodule. ..
  48. Regulation of Apical Polarity in Breast Cancer
    SOPHIE LELIEVRE; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  49. SERM Regulation of PAK Pathway in Endometrial Cancer
    Rakesh Kumar; Fiscal Year: 2006
    ..abstract_text> ..
  50. NuMA function in nonmalignant and malignant breast cells
    SOPHIE LELIEVRE; Fiscal Year: 2008
    ..Thus, it is time to emphasize the role of structural nuclear proteins in gene transcription in order to get a complete picture of gene expression control. ..
  51. Roles for ING4 as a tumor supressor in breast cancer
    Suwon Kim; Fiscal Year: 2008
    ....
  52. PTHrP on normal osteoblast differentiation and function
    RAMIRO TORIBIO; Fiscal Year: 2007
    ..Dr. Thomas Rosol's laboratory will provide an excellent environment for developing the skills necessary to become a successful independent researcher. ..
  53. MTA1 IN ONCOGENESIS
    Rakesh Kumar; Fiscal Year: 2009
    ..As molecule studied here and radiotherapy are not cancer specific, lessons learned from the current study will have a significant impact on other cancers with increased MTA1. ..
  54. Identification of Breast Tumor Secretome Changes Throughout Tumor Progression
    Baogang Xu; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  55. Pak1 - PIN Pathway in Breast Cancer Progression
    Rakesh Kumar; Fiscal Year: 2008
    ..Our proposed research is significant as this research might form the basis for new advances in identifying novel molecular targets, detecting, preventing and treating breast cancer, by identifying PIN as a key regulatory nodule. ..
  56. Roles for ING4 as a tumor suppressor in breast cancer
    Suwon Kim; Fiscal Year: 2006
    ....
  57. Pak1 and Hormone Response in Breast Cancer Progression
    Rakesh Kumar; Fiscal Year: 2008
    ..This research is significant in that the knowledge gained from this research will enhance our understanding of the critical regulatory pathways with established roles in breast cancer progression. ..
  58. HER2 Pathway in Breast Cancer Progression and Treatment
    Rakesh Kumar; Fiscal Year: 2007
    ..abstract_text> ..
  59. SERM Regulation of PAK Pathway in Endometrial Cancer
    Rakesh Kumar; Fiscal Year: 2007
    ..abstract_text> ..
  60. Regulation of Cellular Zn Redistribution: A Role of ZnT2
    SHANNON KELLEHER; Fiscal Year: 2008
    ..Thus, this application has significance for improving public health outcomes and advancing our understanding of basic cellular mechanisms. ..
  61. SERM Regulation of PAK Pathway in Endometrial Cancer
    Rakesh Kumar; Fiscal Year: 2008
    ..abstract_text> ..
  62. PTHrP on normal osteoblast differentiation and function
    RAMIRO TORIBIO; Fiscal Year: 2006
    ..Dr. Thomas Rosol's laboratory will provide an excellent environment for developing the skills necessary to become a successful independent researcher. ..
  63. Regulation of Cellular Zn Redistribution: A Role of ZnT2
    SHANNON KELLEHER; Fiscal Year: 2009
    ..Thus, this application has significance for improving public health outcomes and advancing our understanding of basic cellular mechanisms. ..
  64. NuMA function in nonmalignant and malignant breast cells
    SOPHIE LELIEVRE; Fiscal Year: 2007
    ..Thus, it is time to emphasize the role of structural nuclear proteins in gene transcription in order to get a complete picture of gene expression control. ..
  65. Pak1 and Hormone Response in Breast Cancer Progression
    Rakesh Kumar; Fiscal Year: 2007
    ..This research is significant in that the knowledge gained from this research will enhance our understanding of the critical regulatory pathways with established roles in breast cancer progression. ..
  66. MTA1 IN ONCOGENESIS
    Rakesh Kumar; Fiscal Year: 2008
    ..The proposal is designed to establish the mechanism by which MTA1 contributes to the development of tumorigenic phenotypes in mammary epithelial cells and tumors. [unreadable] [unreadable] [unreadable]..
  67. PTHrP on normal osteoblast differentiation and function
    RAMIRO TORIBIO; Fiscal Year: 2008
    ..Dr. Thomas Rosol's laboratory will provide an excellent environment for developing the skills necessary to become a successful independent researcher. ..
  68. Pak1 - PIN Pathway in Breast Cancer Progression
    Rakesh Kumar; Fiscal Year: 2004
    ..Our proposed research is significant as this research might form the basis for new advances in identifying novel molecular targets, detecting, preventing and treating breast cancer, by identifying PIN as a key regulatory nodule. ..
  69. Pak1 in Mammary Gland Development and Carcinogenesis
    Rakesh Kumar; Fiscal Year: 2001
    ....
  70. Role of Metastatic Tumor Antigen-1 in Mammary Gland
    Rakesh Kumar; Fiscal Year: 2003
    ..abstract_text> ..