animal mammary glands

Summary

Summary: MAMMARY GLANDS in the non-human MAMMALS.

Top Publications

  1. pmc Candidate regulators of mammary branching morphogenesis identified by genome-wide transcript analysis
    Hosein Kouros-Mehr
    Department of Anatomy, Biomedical Sciences Program, University of California, San Francisco 94143 0452, USA
    Dev Dyn 235:3404-12. 2006
  2. ncbi Generation of a functional mammary gland from a single stem cell
    Mark Shackleton
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Nature 439:84-8. 2006
  3. ncbi Gata-3 is an essential regulator of mammary-gland morphogenesis and luminal-cell differentiation
    Marie Liesse Asselin-Labat
    VBCRC Laboratory, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
    Nat Cell Biol 9:201-9. 2007
  4. pmc Expression of the neu protooncogene in the mammary epithelium of transgenic mice induces metastatic disease
    C T Guy
    Institute for Molecular Biology and Biotechnology, McMaster University, Hamilton, Ontario, Canada
    Proc Natl Acad Sci U S A 89:10578-82. 1992
  5. ncbi Notch signaling regulates mammary stem cell function and luminal cell-fate commitment
    Toula Bouras
    VBCRC Laboratory, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
    Cell Stem Cell 3:429-41. 2008
  6. ncbi WNT signals are required for the initiation of hair follicle development
    Thomas Andl
    Department of Dermatology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Dev Cell 2:643-53. 2002
  7. ncbi Stat5a is mandatory for adult mammary gland development and lactogenesis
    X Liu
    Laboratory of Biochemistry and Metabolism, National Institute of Diabetes and Digestive and Kidney Diseases NIDDK, National Institutes of Health NIH, Bethesda, Maryland 20892 1812, USA
    Genes Dev 11:179-86. 1997
  8. pmc GATA-3 maintains the differentiation of the luminal cell fate in the mammary gland
    Hosein Kouros-Mehr
    Department of Anatomy and the Biomedical Sciences Program, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
    Cell 127:1041-55. 2006
  9. ncbi Mice lacking progesterone receptor exhibit pleiotropic reproductive abnormalities
    J P Lydon
    Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Genes Dev 9:2266-78. 1995
  10. ncbi Information networks in the mammary gland
    Lothar Hennighausen
    Laboratory of Genetics and Physiology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Rev Mol Cell Biol 6:715-25. 2005

Research Grants

Detail Information

Publications314 found, 100 shown here

  1. pmc Candidate regulators of mammary branching morphogenesis identified by genome-wide transcript analysis
    Hosein Kouros-Mehr
    Department of Anatomy, Biomedical Sciences Program, University of California, San Francisco 94143 0452, USA
    Dev Dyn 235:3404-12. 2006
    ..We discuss the potential roles of these genes in mammary branching morphogenesis...
  2. ncbi Generation of a functional mammary gland from a single stem cell
    Mark Shackleton
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Nature 439:84-8. 2006
    ..Our data establish that single cells within the Lin-CD29hiCD24+ population are multipotent and self-renewing, properties that define them as MaSCs...
  3. ncbi Gata-3 is an essential regulator of mammary-gland morphogenesis and luminal-cell differentiation
    Marie Liesse Asselin-Labat
    VBCRC Laboratory, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
    Nat Cell Biol 9:201-9. 2007
    ..These studies provide evidence for the existence of an epithelial hierarchy within the mammary gland and establish Gata-3 as a critical regulator of luminal differentiation...
  4. pmc Expression of the neu protooncogene in the mammary epithelium of transgenic mice induces metastatic disease
    C T Guy
    Institute for Molecular Biology and Biotechnology, McMaster University, Hamilton, Ontario, Canada
    Proc Natl Acad Sci U S A 89:10578-82. 1992
    ..Interestingly, many of the tumor-bearing transgenic mice developed secondary metastatic tumors in the lung. These observations suggest that overexpression of the unactivated neu protein can induce metastatic disease after long latency...
  5. ncbi Notch signaling regulates mammary stem cell function and luminal cell-fate commitment
    Toula Bouras
    VBCRC Laboratory, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
    Cell Stem Cell 3:429-41. 2008
    ..These findings reveal key roles for Notch signaling in MaSCs and luminal cell commitment and further suggest that inappropriate Notch activation promotes the self-renewal and transformation of luminal progenitor cells...
  6. ncbi WNT signals are required for the initiation of hair follicle development
    Thomas Andl
    Department of Dermatology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Dev Cell 2:643-53. 2002
    ..This phenotype indicates that activation of WNT signaling in the skin precedes, and is required for, localized expression of regulatory genes and initiation of hair follicle placode formation...
  7. ncbi Stat5a is mandatory for adult mammary gland development and lactogenesis
    X Liu
    Laboratory of Biochemistry and Metabolism, National Institute of Diabetes and Digestive and Kidney Diseases NIDDK, National Institutes of Health NIH, Bethesda, Maryland 20892 1812, USA
    Genes Dev 11:179-86. 1997
    ..These results document that Stat5a is the principal and an obligate mediator of mammopoietic and lactogenic signaling...
  8. pmc GATA-3 maintains the differentiation of the luminal cell fate in the mammary gland
    Hosein Kouros-Mehr
    Department of Anatomy and the Biomedical Sciences Program, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
    Cell 127:1041-55. 2006
    ..This suggests that GATA-3 actively maintains luminal epithelial differentiation in the adult mammary gland, which raises important implications for the pathogenesis of breast cancer...
  9. ncbi Mice lacking progesterone receptor exhibit pleiotropic reproductive abnormalities
    J P Lydon
    Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Genes Dev 9:2266-78. 1995
    ..Collectively, these results provide direct support for progesterone's role as a pleiotropic coordinator of diverse reproductive events that together ensure species survival...
  10. ncbi Information networks in the mammary gland
    Lothar Hennighausen
    Laboratory of Genetics and Physiology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Rev Mol Cell Biol 6:715-25. 2005
    ..Steroids and simple peptide hormones initiate and carry out complex developmental programmes, and reverse genetics has been used to define the underlying mechanistic connections...
  11. ncbi Purification and unique properties of mammary epithelial stem cells
    John Stingl
    Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver V5Z 1L3, British Columbia, Canada
    Nature 439:993-7. 2006
    ..The mammary stem cells are also a rapidly cycling population in the normal adult and have molecular features indicative of a basal position in the mammary epithelium...
  12. pmc Collective epithelial migration and cell rearrangements drive mammary branching morphogenesis
    Andrew J Ewald
    Department of Anatomy and Program in Cell Biology, University of California, San Francisco, San Francisco, CA 94143, USA
    Dev Cell 14:570-81. 2008
    ..Significantly, we observed that normal epithelium and neoplastic hyperplasias are organized similarly, suggesting common mechanisms of epithelial growth...
  13. ncbi Origin and secretion of milk lipids
    I H Mather
    Department of Animal and Avian Sciences, University of Maryland, College Park 20742, USA
    J Mammary Gland Biol Neoplasia 3:259-73. 1998
    ..A combination of both mechanisms may be possible. Following secretion, a fraction of the membrane surrounding the globules may be shed from the droplets and give rise to membrane fragments in the skim milk phase...
  14. pmc Stromal effects on mammary gland development and breast cancer
    Bryony S Wiseman
    Department of Anatomy, University of California, 513 Parnassus Avenue, San Francisco, CA 94143, USA
    Science 296:1046-9. 2002
    ..To find cures for diseases like breast cancer that rely on epithelial-stromal crosstalk, we must understand how these different cell types communicate with each other...
  15. ncbi Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome
    R Nusse
    Cell 31:99-109. 1982
    ..We propose that tumorigenesis by MMTV is strongly favored by proviral insertion within the int1 locus, perhaps as a consequence of enhanced expression of a novel cellular oncogene...
  16. ncbi Mammary gland, limb and yolk sac defects in mice lacking Tbx3, the gene mutated in human ulnar mammary syndrome
    Todd G Davenport
    Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, 701 W 168th Street, New York, NY 10032, USA
    Development 130:2263-73. 2003
    ....
  17. pmc Paracrine signaling through the epithelial estrogen receptor alpha is required for proliferation and morphogenesis in the mammary gland
    Sonia Mallepell
    National Center of Competence in Research Molecular Oncology, Swiss Institute for Experimental Cancer Research, 155 Chemin des Boveresses, CH 1066 Epalinges s Lausanne, Switzerland
    Proc Natl Acad Sci U S A 103:2196-201. 2006
    ....
  18. ncbi Single-step induction of mammary adenocarcinoma in transgenic mice bearing the activated c-neu oncogene
    W J Muller
    Harvard Medical School Department of Genetics, Boston, Massachusetts 02115
    Cell 54:105-15. 1988
    ....
  19. ncbi Role of FGF10/FGFR2b signaling during mammary gland development in the mouse embryo
    Arnaud André Mailleux
    UMR144 CNRS Institut Curie, 26 rue d Ulm 75248 Paris Cedex 05, France
    Development 129:53-60. 2002
    ..Our results also suggest that FGF signaling is involved in the maintenance of mammary bud 4, and that Fgf10 deficient epithelium can undergo branching morphogenesis into the mammary fat pad precursor...
  20. ncbi Hormonal regulation of mammary differentiation and milk secretion
    Margaret C Neville
    Department of Physiology and Biophysics, University of Colorado Health Sciences Center, Denver 80262, USA
    J Mammary Gland Biol Neoplasia 7:49-66. 2002
    ....
  21. ncbi Molecular heterogeneity of breast carcinomas and the cancer stem cell hypothesis
    John Stingl
    Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK
    Nat Rev Cancer 7:791-9. 2007
    ..Drawing such parallels might help to unravel the molecular nature of the initiating events in breast cancer and might have substantial clinical implications...
  22. ncbi Pubertal mammary gland development: insights from mouse models
    Jillian Howlin
    UCD School of Biomolecular and Biomedical Science, Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland, and Department of Laboratory Medicine, Malmo University Hospital, Sweden
    J Mammary Gland Biol Neoplasia 11:283-97. 2006
    ....
  23. pmc The Ets transcription factor Elf5 specifies mammary alveolar cell fate
    Samantha R Oakes
    Cancer Research Program, Garvan Institute of Medical Research, Darlinghurst, New South Wales 2010, Australia
    Genes Dev 22:581-6. 2008
    ..Thus Elf5 specifies the differentiation of CD61+ progenitors to establish the secretory alveolar lineage during pregnancy, providing a link between prolactin, transcriptional events, and alveolar development...
  24. ncbi Functional development of the mammary gland: use of expression profiling and trajectory clustering to reveal changes in gene expression during pregnancy, lactation, and involution
    Michael C Rudolph
    Department of Physiology and Biophysics, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Mammary Gland Biol Neoplasia 8:287-307. 2003
    ..With progesterone withdrawal, PRL and IGF-1 signaling are activated, in turn activating Akt/PKB and the SREBPs, leading to increased lipid synthesis...
  25. ncbi Mammary gland development and tumorigenesis in estrogen receptor knockout mice
    W P Bocchinfuso
    Receptor Biology Section, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Mammary Gland Biol Neoplasia 2:323-34. 1997
    ..These studies provide the impetus to evaluate the effect of other oncogenes in mammary tumorigenesis in the absence of estrogen/ER signaling...
  26. ncbi Label-retaining epithelial cells in mouse mammary gland divide asymmetrically and retain their template DNA strands
    Gilbert H Smith
    Laboratory of Mammary Gland Biology and Tumorigenesis, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
    Development 132:681-7. 2005
    ....
  27. ncbi Mammary development in the embryo and adult: a journey of morphogenesis and commitment
    Christine J Watson
    Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK
    Development 135:995-1003. 2008
    ..A surprising recent discovery has been that mammary epithelial cells commit to differentiated lineages using the same signalling pathways that regulate lineage determination in T helper cells...
  28. ncbi The osteoclast differentiation factor osteoprotegerin-ligand is essential for mammary gland development
    J E Fata
    Department of Medical Biophysics, Ontario Cancer Institute, University of Toronto, Canada
    Cell 103:41-50. 2000
    ..These data provide a novel paradigm in mammary gland development and an evolutionary rationale for hormonal regulation and gender bias of osteoporosis in females...
  29. pmc Key stages in mammary gland development. Secretory activation in the mammary gland: it's not just about milk protein synthesis!
    Steven M Anderson
    Department of Pathology, University of Colorado Health Sciences Center, East 17th Avenue, Aurora, CO 80045, USA
    Breast Cancer Res 9:204. 2007
    ....
  30. ncbi Targeted inactivation of the EGF and amphiregulin genes reveals distinct roles for EGF receptor ligands in mouse mammary gland development
    N C Luetteke
    Department of Biochemistry and Biophysics, UNC Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7295, USA
    Development 126:2739-50. 1999
    ..Finally, the additional loss of growth factors from pups nursed by triple null dams further worsened their survival and growth, establishing functions for both maternal- and neonatal-derived growth factors...
  31. ncbi Metabolic regulation in the lactating mammary gland: a lipid synthesizing machine
    Michael C Rudolph
    Department of Physiology and Biophysics, University of Colorado Health Sciences Center at Fitzsimmons, Aurora, Colorado 80045, USA
    Physiol Genomics 28:323-36. 2007
    ..They also implicate the transcription factor SREBP-1c in regulation of part of the pathway...
  32. ncbi ACSL1, AGPAT6, FABP3, LPIN1, and SLC27A6 are the most abundant isoforms in bovine mammary tissue and their expression is affected by stage of lactation
    Massimo Bionaz
    Mammalian NutriPhysioGenomics, Department of Animal Sciences and Division of Nutritional Sciences, University of Illinois, Urbana, Illinois 61801, USA
    J Nutr 138:1019-24. 2008
    ..Results suggest that SLC27A6, ACSL1, FABP3, AGPAT6, and LPIN1 coordinately regulate the channeling of fatty acids toward copious milk fat synthesis in bovine mammary...
  33. pmc Tissue geometry determines sites of mammary branching morphogenesis in organotypic cultures
    Celeste M Nelson
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Science 314:298-300. 2006
    ..These results reveal that tissue geometry can control organ morphogenesis by defining the local cellular microenvironment, a finding that has relevance to control of invasion and metastasis...
  34. pmc The MAPK(ERK-1,2) pathway integrates distinct and antagonistic signals from TGFalpha and FGF7 in morphogenesis of mouse mammary epithelium
    Jimmie E Fata
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Dev Biol 306:193-207. 2007
    ..Our findings indicate that expression of morphogenetic effectors, proliferation, and cell-type decisions during mammary organoid morphogenesis are intimately dependent on the duration of activation of MAPK(ERK1,2) activation...
  35. ncbi Mouse embryonic mammogenesis as a model for the molecular regulation of pattern formation
    Jacqueline M Veltmaat
    UMR 144 CNRS Institut Curie, Section de Recherche, Equipe de Morphogenèse Cellulaire et Progression Tumorale, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    Differentiation 71:1-17. 2003
    ..For future investigations in the field, such a unique molecular identity of each mammary rudiment should be of critical concern...
  36. ncbi Bovine TLR2 and TLR4 properly transduce signals from Staphylococcus aureus and E. coli, but S. aureus fails to both activate NF-kappaB in mammary epithelial cells and to quickly induce TNFalpha and interleukin-8 (CXCL8) expression in the udder
    Wei Yang
    Research Institute for the Biology of Farm Animals FBN, Wilhelm Stahl Allee 2, 18196 Dummerstorf, Germany
    Mol Immunol 45:1385-97. 2008
    ..Rather, the pathogen causing subclinical mastitis impairs NF-kappaB activation in MEC thereby severely weakening the immune response in the udder...
  37. ncbi Signaling pathways in mammary gland development
    L Hennighausen
    Laboratory of Genetics and Physiology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 0822, USA
    Dev Cell 1:467-75. 2001
    ..Here we discuss the signaling pathways that have been adopted by the mammary gland for its own purposes, and the functions they perform...
  38. pmc A plasma kallikrein-dependent plasminogen cascade required for adipocyte differentiation
    S Selvarajan
    Department of Anatomy, Box 0452, University of California, 513 Parnasssus Avenue, San Francisco, California 94143, USA
    Nat Cell Biol 3:267-75. 2001
    ..PKal is therefore a physiological regulator that acts in the Plg cascade during adipogenesis. We propose that the Plg cascade fosters adipocyte differentiation by degradation of the fibronectin-rich preadipocyte stromal matrix...
  39. ncbi Effect of conditional knockout of the type II TGF-beta receptor gene in mammary epithelia on mammary gland development and polyomavirus middle T antigen induced tumor formation and metastasis
    Elizabeth Forrester
    Department of Cancer Biology, Ingram Cancer Center, Nashville, Tennessee, USA
    Cancer Res 65:2296-302. 2005
    ....
  40. ncbi Contribution of the ABC transporters Bcrp1 and Mdr1a/1b to the side population phenotype in mammary gland and bone marrow of mice
    Johan W Jonker
    Division of Experimental Therapy, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Stem Cells 23:1059-65. 2005
    ..Interestingly, bone marrow of Mdr1a/1b-/- mice frequently displayed an elevated SP, which was reversible by the Bcrp1 inhibitor Ko143, suggesting that Bcrp1 can compensate for the loss of Mdr1a/1b in bone marrow...
  41. ncbi Lipopolysaccharide and lipoteichoic acid induce different innate immune responses in bovine mammary epithelial cells
    Ylva Strandberg
    CSIRO Livestock Industries, Queensland Bioscience Precinct, 306 Carmody Road, St Lucia 4067, QLD, Australia
    Cytokine 31:72-86. 2005
    ..It was concluded that bovine mammary epithelial cells have a strong but differential capacity to mount innate immune responses to bacterial cell wall components...
  42. pmc P21-activated kinase-1 phosphorylates and transactivates estrogen receptor-alpha and promotes hyperplasia in mammary epithelium
    Rui An Wang
    Department of Molecular and Cellular Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030 4009, USA
    EMBO J 21:5437-47. 2002
    ..These findings reveal a novel role for the Pak1-ER pathway in promoting hyperplasia in mammary epithelium...
  43. ncbi Unique and shared functions of different connexins in mice
    A Plum
    Institut fur Genetik, Universitat Bonn, Roemerstrasse164, D 53117, Bonn, Germany
    Curr Biol 10:1083-91. 2000
    ....
  44. ncbi Parity-induced mouse mammary epithelial cells are pluripotent, self-renewing and sensitive to TGF-beta1 expression
    Corinne A Boulanger
    Mammary Biology and Tumorigenesis Laboratory, National Cancer Institute, Bethesda, MD 20892, USA
    Oncogene 24:552-60. 2005
    ....
  45. pmc Interactions between FGF and Wnt signals and Tbx3 gene expression in mammary gland initiation in mouse embryos
    Maxwell C Eblaghie
    Division of Cell and Developmental Biology, Faculty of Life Sciences, Wellcome Trust Biocentre, University of Dundee, Scotland, UK
    J Anat 205:1-13. 2004
    ..These data, taken together with previous findings, suggest a model in which Tbx3 expression is induced and maintained in early gland initiation by both Wnt and Fgf signalling through FGFR1...
  46. ncbi Parity-induced mammary epithelial cells facilitate tumorigenesis in MMTV-neu transgenic mice
    MaLinda D Henry
    Eppley Institute for Research in Cancer and Allied Diseases and the Department of Pathology and Microbiology, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, NE 68198 6805, USA
    Oncogene 23:6980-5. 2004
    ....
  47. ncbi Parathyroid hormone-related protein maintains mammary epithelial fate and triggers nipple skin differentiation during embryonic breast development
    J Foley
    Medical Sciences, Indiana University School of Medicine, Bloomington, IN 47405, USA
    Development 128:513-25. 2001
    ..Finally, PTHrP signaling regulates the epidermal and mesenchymal expression of LEF1 and (&bgr;)-catenin, suggesting that these changes in cell fate involve an interaction between the PTHrP and Wnt signaling pathways...
  48. ncbi Prolactin, growth hormone, and epidermal growth factor activate Stat5 in different compartments of mammary tissue and exert different and overlapping developmental effects
    M I Gallego
    Laboratory of Genetics and Physiology, National Institute of Diabetes, Digestive and Kidney Diseases, Bethesda, Maryland 20892, USA
    Dev Biol 229:163-75. 2001
    ..Our findings demonstrate that GH, Prl, and EGF activate Stat5 in separate compartments, which in turn reflects their specific roles in ductal and alveolar development and differentiation...
  49. pmc Beta-casein gene promoter activity is regulated by the hormone-mediated relief of transcriptional repression and a mammary-gland-specific nuclear factor
    M Schmitt-Ney
    Friedrich Miescher Institute, Basel, Switzerland
    Mol Cell Biol 11:3745-55. 1991
    ..The DNA sequences recognized by all five of these nuclear factors are conserved in the promoters of different casein genes from several species, confirming their importance in the regulation of milk protein gene transcription...
  50. ncbi Cyclin D1 provides a link between development and oncogenesis in the retina and breast
    P Sicinski
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, USA
    Cell 82:621-30. 1995
    ..Thus, steroid-induced proliferation of mammary epithelium during pregnancy may be driven through cyclin D1...
  51. ncbi Activation of BAD by therapeutic inhibition of epidermal growth factor receptor and transactivation by insulin-like growth factor receptor
    Andrew P Gilmore
    School of Biological Sciences, University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, United Kingdom
    J Biol Chem 277:27643-50. 2002
    ..Our results indicate that by targeting a growth factor-mediated survival signaling pathway, BAD phosphorylation can be manipulated therapeutically to induce apoptosis...
  52. pmc Maternal PPAR gamma protects nursing neonates by suppressing the production of inflammatory milk
    Yihong Wan
    Howard Hughes Medical Institute, Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Genes Dev 21:1895-908. 2007
    ..Therefore, maternal PPAR gamma is pivotal for maintaining the quality of milk and protecting the nursing newborns by suppressing the production of inflammatory lipids in the lactating mammary gland...
  53. ncbi Endogenous protein kinase CK2 participates in Wnt signaling in mammary epithelial cells
    D H Song
    Departments of Medicine, Chemistry, and Microbiology, Boston Medical Center and Boston University, Boston, Massachusetts 02118, USA
    J Biol Chem 275:23790-7. 2000
    ..These results demonstrate that endogenous CK2 is a positive regulator of Wnt signaling and growth of mammary epithelial cells...
  54. pmc Identification of immune genes and proteins involved in the response of bovine mammary tissue to Staphylococcus aureus infection
    Ylva C Strandberg Lutzow
    Co operative Research Centre for Innovative Dairy Products, Australia
    BMC Vet Res 4:18. 2008
    ..Moreover, the effect of infection on the presence of bioactive innate immune proteins in milk is also unclear. The nature of these responses may determine the susceptibility of the tissue and its ability to resolve the infection...
  55. pmc Mammary gland factor (MGF) is a novel member of the cytokine regulated transcription factor gene family and confers the prolactin response
    H Wakao
    Friedrich Miescher Institute, Basel, Switzerland
    EMBO J 13:2182-91. 1994
    ..Prolactin-dependent transactivation of a beta-casein promoter-luciferase reporter gene construct was observed in transfected cells...
  56. pmc Cloning and expression of Stat5 and an additional homologue (Stat5b) involved in prolactin signal transduction in mouse mammary tissue
    X Liu
    Laboratory of Biochemistry and Metabolism, National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 92:8831-5. 1995
    ..The increase of Stat5 expression during pregnancy coincides with the activation of the WAP gene...
  57. ncbi Bax and Bcl-xs are induced at the onset of apoptosis in involuting mammary epithelial cells
    K Heermeier
    Laboratory of Biochemistry and Metabolism, National Institutes of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892 1812, USA
    Mech Dev 56:197-207. 1996
    ..These findings point to a significant role for Bax and Bcl-xS in the regulation of apoptosis of secretory alveolar cells during involution...
  58. pmc Ras and TGF[beta] cooperatively regulate epithelial cell plasticity and metastasis: dissection of Ras signaling pathways
    Elzbieta Janda
    Institute of Molecular Pathology, A 1030 Vienna, Austria
    J Cell Biol 156:299-313. 2002
    ..Thus, EMT seems to be a close in vitro correlate of metastasis, both requiring synergism between TGFbeta-R and Raf/MAPK signaling...
  59. pmc Extracellular matrix-regulated gene expression requires cooperation of SWI/SNF and transcription factors
    Ren Xu
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    J Biol Chem 282:14992-9. 2007
    ..Thus, extracellular matrix- and prolactin-regulated transcription of the mammary-specific casein genes requires the concerted action of chromatin remodeling enzymes and transcription factors...
  60. ncbi Prolactin regulation of mammary gland development
    Samantha R Oakes
    Development Group, Cancer Research Program, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, NSW, 2010, Australia
    J Mammary Gland Biol Neoplasia 13:13-28. 2008
    ..Here we focus on providing an over-view of prolactin action during development of the model murine mammary gland...
  61. ncbi Identification of differentially expressed microRNAs during the development of Chinese murine mammary gland
    Chunmei Wang
    Key laboratory Dairy Science of Education Ministry Northeast Agricultural University, Harbin 15000, China
    J Genet Genomics 34:966-73. 2007
    ..These results indicate that miRNAs are functionally involved in mammary gland development...
  62. ncbi Prolactin controls mammary gland development via direct and indirect mechanisms
    C Brisken
    Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02142 1479, USA
    Dev Biol 210:96-106. 1999
    ....
  63. pmc Laminin mediates tissue-specific gene expression in mammary epithelia
    C H Streuli
    School of Biological Sciences, University of Manchester, Zurich
    J Cell Biol 129:591-603. 1995
    ..Our results demonstrate that laminin can direct tissue-specific gene expression in epithelial cells through its globular domain...
  64. ncbi Cooperation of signalling pathways in embryonic mammary gland development
    Gertraud W Robinson
    Laboratory of Genetics and Physiology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Building 8, Room 101, 8 Center Drive, Bethesda, Maryland 20892 20822, USA
    Nat Rev Genet 8:963-72. 2007
    ..Some of these signals contribute to aberrant mammary development in humans and are deregulated in cancer...
  65. ncbi Transcriptional profiling of mammary gland side population cells
    Fariba Behbod
    Department of Molecular and Cellular Biology, DeBakey Building, M638a, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030 3498, USA
    Stem Cells 24:1065-74. 2006
    ..In conclusion, microarray gene profiling suggests that MG-SPs are a lineage-deficient mammary gland subpopulation expressing key genes involved in cell cycle regulation, development, and angiogenesis...
  66. ncbi An adjunct mammary epithelial cell population in parous females: its role in functional adaptation and tissue renewal
    Kay Uwe Wagner
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Rm 8009, Omaha, NE 68198 6805, USA
    Development 129:1377-86. 2002
    ..e. ductal morphogenesis and lobulogenesis). We propose that this parity-induced population contributes importantly to the biological differences between the mammary glands of parous and nulliparous females...
  67. ncbi Endocrine-disrupting compounds and mammary gland development: early exposure and later life consequences
    Suzanne E Fenton
    U S Environmental Protection Agency, ORD, National Health and Environmental Effects Research Laboratory, Reproductive Toxicology Division, MD 67, Research Triangle Park, North Carolina 27711, USA
    Endocrinology 147:S18-24. 2006
    ....
  68. ncbi Cellular turnover in the mammary gland is correlated with systemic levels of progesterone and not 17beta-estradiol during the estrous cycle
    J E Fata
    Department of Medical Biophysics, Ontario Cancer Institute, University of Toronto, 610 University Avenue, Toronto, Ontario, Canada M5G 2M9
    Biol Reprod 65:680-8. 2001
    ..We propose that the cyclical turnover of epithelial cells within the adult mammary tissue is a sum of spatial and functional coordination of hormonal and matrix regulatory factors...
  69. ncbi Stem cells in normal breast development and breast cancer
    Gabriela Dontu
    Department of Internal Medicine, Hematology Oncology, Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA
    Cell Prolif 36:59-72. 2003
    ..This phenotypic diversity is driven by a small subset of mammary tumour stem cells. We will discuss the important implications of this mammary tumour stem-cell model...
  70. pmc Precocious mammary gland development in P-cadherin-deficient mice
    G L Radice
    Howard Hughes Medical Institute, Center for Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Cell Biol 139:1025-32. 1997
    ..Furthermore, the loss of P-cadherin from the myoepithelium has uncovered a novel function for this tissue in maintaining the undifferentiated state of the underlying secretory epithelium...
  71. pmc MET and MYC cooperate in mammary tumorigenesis
    Alana L Welm
    G W Hooper Research Foundation and Department of Microbiology and Immunology, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 102:4324-9. 2005
    ..The approach described here should provide a useful model with which to efficiently test effects of various genes on tumor development in the breast...
  72. ncbi Peroxisome proliferator-activated receptor-gamma activation and long-chain fatty acids alter lipogenic gene networks in bovine mammary epithelial cells to various extents
    A K G Kadegowda
    Department of Animal and Avian Sciences, University of Maryland, College Park, Maryland 20742, USA
    J Dairy Sci 92:4276-89. 2009
    ..The coordinated upregulation of lipogenic gene networks in response to ROSI and saturated LCFA offers support for PPARG activation in regulating bovine milk fat synthesis...
  73. pmc Neural and mammary gland defects in ErbB4 knockout mice genetically rescued from embryonic lethality
    Hester Tidcombe
    Division of Neurobiology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, United Kingdom
    Proc Natl Acad Sci U S A 100:8281-6. 2003
    ..However, during pregnancy, mammary lobuloalveoli fail to differentiate correctly and lactation is defective. Rescued mice also display aberrant cranial nerve architecture and increased numbers of large interneurons within the cerebellum...
  74. pmc PERK-dependent regulation of lipogenesis during mouse mammary gland development and adipocyte differentiation
    Ekaterina Bobrovnikova-Marjon
    The Leonard and Madlyn Abramson Family Cancer Research Institute and Cancer Center, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 105:16314-9. 2008
    ..These findings implicate PERK as a physiologically relevant regulator of the lipogenic pathway...
  75. ncbi p63: a novel myoepithelial cell marker in canine mammary tissues
    A Gama
    Department of Pathology and Veterinary Clinics, University of Trás os Montes e Alro Douro, Vila Real, Portugal
    Vet Pathol 40:412-20. 2003
    ..In conclusion, the present study reveals p63 as a sensitive and highly specific marker of myoepithelial cells in canine mammary tissues, and the authors suggest p63 as an additional marker for defining myoepithelial histogenesis...
  76. ncbi Constitutive activation of smoothened (SMO) in mammary glands of transgenic mice leads to increased proliferation, altered differentiation and ductal dysplasia
    Ricardo C Moraes
    Baylor Breast Center and Department of Molecular and Cellular Biology, Room N1210 MS BCM600, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Development 134:1231-42. 2007
    ..Our data suggest that altered hedgehog signaling may contribute to breast cancer development by stimulating proliferation, and by increasing the pool of division-competent cells capable of anchorage-independent growth...
  77. ncbi Persistent changes in gene expression induced by estrogen and progesterone in the rat mammary gland
    M R Ginger
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030 3411, USA
    Mol Endocrinol 15:1993-2009. 2001
    ..These results provide the first support at the molecular level for the hypothesis that hormone-induced persistent changes in gene expression are present in the involuted mammary gland...
  78. ncbi The Pea3 Ets transcription factor regulates differentiation of multipotent progenitor cells during mammary gland development
    Natasza A Kurpios
    Department of Biochemistry and Biomedical Sciences, Centre for Functional Genomics, McMaster University, Hamilton, Ontario, Canada
    Dev Biol 325:106-21. 2009
    ..We propose that Pea3 functions in multipotential progenitors to regulate their lineage-specific differentiation potential...
  79. ncbi Comparison of steroid receptor expression in normal, dysplastic, and neoplastic canine and feline mammary tissues
    F Millanta
    Department of Animal Pathology, School of Veterinary Medicine, University of Pisa, Viale delle Piagge, 2, I 56124 Pisa, Italy
    Res Vet Sci 79:225-32. 2005
    ..The low percentage of ER-positive invasive carcinomas further demonstrated the aggressive phenotype and behaviour of feline mammary tumours...
  80. ncbi RANK-L and RANK: T cells, bone loss, and mammalian evolution
    Lars E Theill
    Inflammation Drug Discovery Research, One Amgen Center Drive, Thousand Oaks, California 91320 1789, USA
    Annu Rev Immunol 20:795-823. 2002
    ..Modulation of these systems provides us with a unique opportunity to design novel therapeutics to inhibit bone loss in arthritis, periodontal disease, and osteoporosis...
  81. ncbi Invasive potential induced under long-term oxidative stress in mammary epithelial cells
    Kazunori Mori
    Department of Microbiology, Showa University School of Pharmaceutical Sciences, Tokyo, Japan
    Cancer Res 64:7464-72. 2004
    ....
  82. pmc Defective mammary gland morphogenesis in mice lacking the progesterone receptor B isoform
    Biserka Mulac-Jericevic
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 100:9744-9. 2003
    ....
  83. pmc RANK overexpression in transgenic mice with mouse mammary tumor virus promoter-controlled RANK increases proliferation and impairs alveolar differentiation in the mammary epithelia and disrupts lumen formation in cultured epithelial acini
    Eva Gonzalez-Suarez
    Department of Cancer Biology, AW2 D2262, Amgen Inc, 1201 Amgen Court West, Seattle, WA 98119, USA
    Mol Cell Biol 27:1442-54. 2007
    ..Moreover, the increased proliferation and survival observed in a three-dimensional culture system suggests a role for aberrant RANK signaling during breast tumorigenesis...
  84. ncbi A developmental atlas of rat mammary gland histology
    P A Masso-Welch
    Roswell Park Cancer Institute, Buffalo, New York, USA
    J Mammary Gland Biol Neoplasia 5:165-85. 2000
    ..The purpose of this review is to assist researchers in recognizing histological changes in the epithelium and stroma of the rat mammary gland throughout development...
  85. pmc The housekeeping gene xanthine oxidoreductase is necessary for milk fat droplet enveloping and secretion: gene sharing in the lactating mammary gland
    Claudia Vorbach
    Howard Hughes Medical Institute, Department of Human Genetics, University of Utah, Salt Lake City 84112, USA
    Genes Dev 16:3223-35. 2002
    ..About 5% of women experience primary lactation insufficiency. The above observations suggest that human females suffering from xanthinuria, a deficiency in XOR, are potential candidates for lactation problems...
  86. ncbi Differential mammary morphogenesis along the anteroposterior axis in Hoxc6 gene targeted mice
    A Garcia-Gasca
    Center for Molecular and Structural Biology, Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina 29403, USA
    Dev Dyn 219:261-76. 2000
    ..The position-specific phenotypes observed and the potential role for Hoxc6 in mediating hormone-regulated ductal expansion and regression in the adult female are discussed...
  87. ncbi Progesterone signaling and mammary gland morphogenesis
    G Shyamala
    Division of Life Sciences, Lawrence Berkeley National Laboratory, University of California, Berkeley 94720, USA
    J Mammary Gland Biol Neoplasia 4:89-104. 1999
    ....
  88. ncbi Reducing mammary cancer risk through premature stem cell senescence
    C A Boulanger
    Laboratory of Tumor Immunology and Biology, National Cancer Institute, Bethesda, Maryland, MD 20892, USA
    Oncogene 20:2264-72. 2001
    ..The results suggest a positive correlation between the procreative life-span of mammary epithelial stem cells and mammary cancer risk...
  89. pmc WNT/beta-catenin mediates radiation resistance of mouse mammary progenitor cells
    Wendy A Woodward
    Department of Radiation Oncology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 104:618-23. 2007
    ..These data demonstrate that, compared with differentiated cells, progenitor cells have different cell survival properties that may facilitate the development of targeted antiprogenitor cell therapies...
  90. ncbi Epithelial development and differentiation in the mammary gland is not dependent on alpha 3 or alpha 6 integrin subunits
    T C Klinowska
    School of Biological Sciences, University of Manchester, 3 239 Stopford Building, Oxford Road, Manchester, M13 9PT, United Kingdom
    Dev Biol 233:449-67. 2001
    ..This work demonstrates that mammary tissue genetically lacking major laminin-binding integrin receptors is still able to develop and function...
  91. ncbi Genetic manipulation of mammary epithelium by transplantation
    P A Edwards
    Department of Pathology, University of Cambridge, U K
    J Mammary Gland Biol Neoplasia 1:75-89. 1996
    ..Insights into normal development have also been obtained by inappropriate expression of genes such as Wnt-4...
  92. ncbi Insulin-like growth factor-II regulates PTEN expression in the mammary gland
    Roger A Moorehead
    Ontario Cancer Institute University Health Network, University of Toronto, Toronto, Ontario M5G 2M9, Canada
    J Biol Chem 278:50422-7. 2003
    ..Thus, we have identified a novel negative feedback loop within the PI3K pathway where IGF-II induces PTEN expression to modulate its physiologic effects...
  93. ncbi Expression of a truncated Brca1 protein delays lactational mammary development in transgenic mice
    Melissa A Brown
    Department of Medical and Molecular Genetics, King s College London, Guy s Hospital, UK
    Transgenic Res 11:467-78. 2002
    ..They may also have implications for germline carriers of BRCA1 mutations...
  94. pmc Cattle mammary bioreactor generated by a novel procedure of transgenic cloning for large-scale production of functional human lactoferrin
    Penghua Yang
    State Key Laboratory for Agrobiotechnology, China Agricultural University, Beijing, People s Republic of China
    PLoS ONE 3:e3453. 2008
    ..Moreover, the cattle mammary bioreactors generated with this novel procedure produce functional rhLF on an industrial scale...
  95. ncbi Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation
    X Xu
    Genetics of Development and Disease Branch, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Genet 22:37-43. 1999
    ..Our results demonstrate that disruption of Brca1 causes genetic instability and triggers further alterations, including the inactivation of p53, that lead to tumour formation...
  96. ncbi Next stop, the twilight zone: hedgehog network regulation of mammary gland development
    Michael T Lewis
    Baylor College of Medicine, Houston, Texas 77030, USA
    J Mammary Gland Biol Neoplasia 9:165-81. 2004
    ..Further, studies suggest a role for misregulated network function in the progression of breast cancer...
  97. ncbi Innate immune response to intramammary infection with Serratia marcescens and Streptococcus uberis
    Douglas D Bannerman
    Bovine Functional Genomics Laboratory, Beltsville Agricultural Research Center, USDA Agricultural Research Service, Beltsville, MD 20705, USA
    Vet Res 35:681-700. 2004
    ..marcescens infection. Together, these data demonstrate the variability of the innate immune response to two distinct mastitis pathogens...
  98. pmc Signalling pathways implicated in early mammary gland morphogenesis and breast cancer
    Beatrice Howard
    University College London, United Kingdom
    PLoS Genet 2:e112. 2006
    ..Reflecting this intimate connection, a considerable number of signalling pathways have been implicated in both mammary gland morphogenesis and carcinogenesis...
  99. ncbi Targeted disruption of beta1-integrin in a transgenic mouse model of human breast cancer reveals an essential role in mammary tumor induction
    Donald E White
    Department of Medical Sciences, McMaster University, Hamilton, Ontario, L8S 4K1, Canada
    Cancer Cell 6:159-70. 2004
    ..These observations provide a direct demonstration that beta1-integrin plays a critical role in both the initiation and maintenance of mammary tumor growth in vivo...
  100. ncbi Mammary gland development in adult mice requires epithelial and stromal estrogen receptor alpha
    Stefan O Mueller
    Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Endocrinology 143:2357-65. 2002
    ..Immunostaining for ER alpha and PR in the mammary outgrowths supported the view that both stromal and epithelial ER alpha, in cooperation with epithelial PR, govern mammary gland development in adult mice...
  101. ncbi Escherichia coli, but not Staphylococcus aureus triggers an early increased expression of factors contributing to the innate immune defense in the udder of the cow
    Wolfram Petzl
    Clinic for Ruminants, Ludwig Maximilians University, Munich, Germany
    Vet Res 39:18. 2008
    ..Using the established mastitis model, the data clearly demonstrate a pathogen-dependent difference in the time kinetics of induced pathogen receptors and defense molecules...

Research Grants72

  1. IGF-1 Receptor Signaling in Mammary Gland Development
    Darryl Hadsell; Fiscal Year: 2006
    ..abstract_text> ..
  2. PROGESTERONE RECEPTORS IN MAMMARY DEVELOPMENT/NEOPLASIA
    G Shyamala; Fiscal Year: 2001
    ....
  3. P53 AND MOUSE MAMMARY TUMORIGENESIS
    Daniel Medina; Fiscal Year: 2004
    ..In summary, this model allows one to analyze the biological, genetic and molecular consequences of p53 gene deletion in the in situ mammary gland by taking advantage of transplantation methods. ..
  4. BIOLOGY OF NEOPLASTIC TRANSFORMATION IN BREAST CANCER
    Robert Cardiff; Fiscal Year: 2005
    ..The goal of this project is to develop a well-characterized model for breast cancer development and to dissect the molecular pathways involved in tumor formation. ..
  5. GORDON RESEARCH CONFERENCE ON MAMMARY GLAND BIOLOGY
    MARY BARCELLOS HOFF; Fiscal Year: 2003
    ..abstract_text> ..
  6. MECHANISMS OF THE HORMONAL PREVENTION OF BREAST CANCER
    Daniel Medina; Fiscal Year: 2006
    ..The molecular understanding of the fundamental biological events involved in hormone-induced growth and differentiation will provide a rationale for developing new approaches for preventing human breast cancer. ..
  7. ROLE OF STROMA IN MAMMARY GLAND CELL PROLIFERATION
    SANDRA HASLAM; Fiscal Year: 2007
    ..The long-term goal of this proposal is the delineation of the mechanisms of P-dependent growth regulation in the adult normal mammary gland that may lead to novel strategies for the prevention and treatment of breast cancer. ..
  8. PRECLINICAL MODELS OF BREAST CANCER
    Robert Cardiff; Fiscal Year: 2003
    ..The theme of the workshop is "High Throughput Phenotyping: From Mouse to Molecule in One Day!" It will allow the student to examine and compare the best and fastest phenotyping technology currently available. ..
  9. 25TH IABCR CONGRESS CONFERENCE: PERSONALIZED BREAST CANCER THERAPY
    Robert Cardiff; Fiscal Year: 2006
    ..The session will also include a plenary lecture from Dr. A Ullrich who pioneered the concept of targeting the HER2 oncogene in the treatment of breast cancer. [unreadable] [unreadable] [unreadable] [unreadable]..
  10. In Utero Mammary Cancer Risk with Resveratrol and TCDD
    CORAL LAMARTINIERE; Fiscal Year: 2008
    ..Programming breast cancer chemoprevention from in utero exposure to a nutritional agent would be a novel breakthrough for women's health. [unreadable] [unreadable] [unreadable]..
  11. LACTATIONAL EFFECTORS OF TRIACYLGLYCEROL MOBILIZATION
    JAMES MCMANAMAN; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  12. In Utero TCDD Programming for Mammary Cancer
    CORAL LAMARTINIERE; Fiscal Year: 2005
    ..abstract_text> ..
  13. Soy and Estrogen Interactions in the Breast
    J Cline; Fiscal Year: 2009
    ..The proposed work will provide a unique view of an otherwise inaccessible period of breast development in a primate model with high genetic and physiologic similarity to human beings. ..
  14. PHYSIOLOGICAL FACTORS AFFECTING HUMAN LACTATION
    Margaret Neville; Fiscal Year: 2002
    ....
  15. Effects of Dietary Soy on Biomarkers in Prostate Cancer
    J Cline; Fiscal Year: 2004
    ..abstract_text> ..
  16. Genistein Impriting Against Prostate Cancer
    CORAL LAMARTINIERE; Fiscal Year: 2003
    ..We propose this in a dietary model at "physiological concentrations." ..
  17. Genomic Markers of Breast Cancer Prevention Induced by hCG in Women at High Risk
    Jose Russo; Fiscal Year: 2008
    ..This knowledge will serve as the basis for establishing novel genomic signatures as intermediate biomarkers for larger preventive clinical trials at the completion of this project. [unreadable] [unreadable] [unreadable]..
  18. Genomic Basis of Reproductive History on Breast Cancer
    Jose Russo; Fiscal Year: 2006
    ..abstract_text> ..
  19. Prenatal xenoestrogen exposure and mammary cancer
    ANA SOTO; Fiscal Year: 2006
    ..It may even influence public policy about prevention. ..
  20. Xenoestrogens: Genomic and Non-genomic Mechanisms
    Nira Ben Jonathan; Fiscal Year: 2006
    ..The results of these studies should provide much needed experimental foundation for assessing the vulnerability of the pituitary gland to insults by endocrine disruptors. ..
  21. Molecular biomarkers of selenium chemoprevention
    Clement Ip; Fiscal Year: 2006
    ..The goal is to broaden our understanding of the significance of clonal suppression of early transformed cells in selenium protection of cancer. ..
  22. In utero dietary exposure to endocrine disruptors
    Leena Hilakivi Clarke; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  23. P53-dependent responses to toxicants in parous and nulliparous breast
    D Joseph Jerry; Fiscal Year: 2010
    ....
  24. NR4A Nuclear Receptor Function in Leukemia
    Orla M Conneely; Fiscal Year: 2010
    ..abstract_text> ..
  25. Genetic modifiers of mammary tumor susceptibility
    D Jerry; Fiscal Year: 2009
    ..Identificationofgenes thatmodifysusceptibilitytomammarytumors willprovidemarkers for riskassessment andnovel targets for therapeutic intervention. ..
  26. Epigenetic Changes Induced by Estrogens and Xenoestrogens in Breast Cancer
    Jose Russo; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  27. In Vitro Synthesis of Fibrosis Genesis
    CELESTE NELSON; Fiscal Year: 2008
    ..We present here a three-dimensional, microlithography-based model that can be used to break down the key steps involved in the earliest stages of fibrosis genesis. [unreadable] [unreadable] [unreadable]..
  28. PROGESTERONE RECEPTOR A AND B PROTEINS IN REPRODUCTION
    ORLA CONNEELY; Fiscal Year: 2008
    ..abstract_text> ..
  29. Perinatal xenoestrogen exposure: epigenesis and neoplasia
    ANA SOTO; Fiscal Year: 2007
    ..This will also have a great impact on the way we study risk factors and conduct epidemiological studies; it may even influence public policy about breast cancer prevention. [unreadable] [unreadable] [unreadable] [unreadable]..
  30. Selenium molecular signaling in human prostate cancer
    Clement Ip; Fiscal Year: 2007
    ..Aim 4 is to study the transcriptional control of GADD153 by selenium. The proposed research is thus designed to examine systemically the impact of GADD153 induction as a result of selenium treatment. ..
  31. Pregnancy Estrogens, Diet, and Breast Cancer Risk
    Leena Hilakivi Clarke; Fiscal Year: 2005
    ..abstract_text> ..
  32. SELENIUM AND LUNG CANCER RISK
    Henry Thompson; Fiscal Year: 2004
    ..In addition, this work has the potential to provide new biomarkers with which to assess lung cancer risk and its modulation. ..
  33. NEONATAL EFFECTS AND METABOLISM OF XENOESTROGENS
    Nira Ben Jonathan; Fiscal Year: 2003
    ..The results should provide a much needed experimental foundation for assessing the vulnerability of the neuroendocrine system to insults by environmental factors. ..
  34. Profiling Modifications of p53 by Mass Spectrometry
    D Jerry; Fiscal Year: 2003
    ..Optimized procedures will be applied to human tumors to determine the patterns of post-translational modifications by MALDI-ToF. ..
  35. 12th International ISD Conference: Cancer & Development
    Mina Bissell; Fiscal Year: 2002
    ..abstract_text> ..
  36. CELL CELL INTERACTIONS IN PROSTATE CANCER
    Gerald Cunha; Fiscal Year: 2001
    ..These studies should define critical cellular and molecular pathways in both normal and tumorigenic growth of the prostate, and should provide the biological basis of new therapeutic strategies. ..
  37. PROSTATE CELL PROLIFERATION IN CANCER AND AGING
    ANA SOTO; Fiscal Year: 2005
    ..We expect that this research will lead to the development of markers to identify this phenotype, and to the development of specific therapeutic strategies. ..
  38. GORDON CONFERENCE ON ENVIRONMENTAL ENDOCRINE DISRUPTORS
    ANA SOTO; Fiscal Year: 2002
    ..abstract_text> ..
  39. Role of PAX2 in Mammary Development and Cancer
    GARY SILBERSTEIN; Fiscal Year: 2005
    ..Finally, the possibility that PAX2 is a mammary tumor promoter will be evaluated, providing insights into mechanisms of breast cancer progression. ..
  40. PROTEIN KINASES IN YEAST DNA CHECKPOINT PATHWAYS
    David Stern; Fiscal Year: 2009
    ..Aim 3. Molecular techniques will be used for functional analysis of NFBD1/MDC1 in the activities identified in Aim 2. ..
  41. CANCER PREVENTION BY SELENIUM-ENRICHED ALLIUM VEGETABLES
    Clement Ip; Fiscal Year: 2003
    ..The objective is to corroborate the significance of clonal suppression of preneoplastic lesions in selenium protection of cancer. ..
  42. HETEROSPECIFIC CELL/CELL INTERACTIONS IN PROSTATE GROWTH
    Gerald Cunha; Fiscal Year: 2001
    ..Concepts derived from the analysis of basic cellular mechanisms of prostatic growth will be applied to the pathogenesis of BPH. ..
  43. BRCA2 FUNCTION IN MAMMARY EPITHELIAL BIOLOGY
    Lewis Chodosh; Fiscal Year: 2002
    ..We will also determine whether Brca2 is posttranslationally modified following DNA damage in a manner similar to that observed for Brca1. Finally, we will determine whether Brca2 and Brca1 interact during these processes. ..
  44. DEFINITION OF MICROENVIRONMENT IN BREAST CANCER
    Mina Bissell; Fiscal Year: 2008
    ..As loss of appropriate integration of these signals could lead to malignancy, our results may yield new markers and therapeutic strategies to limit or reverse breast tumor progression. ..
  45. Timing of dietary exposure and breast cancer risk
    Leena Hilakivi Clarke; Fiscal Year: 2008
    ..This program aims to develop novel means to prevent some breast cancers by dietary modifications that take place during pregnancy and puberty. ..
  46. LACTOSE SYNTHESIS REGULATION: ROLE OF GLUCOSE TRANSPORT
    PETER HANEY; Fiscal Year: 2002
    ..These will be related to changes in glucose transport activity an lactose synthesis that are essential for milk production. ..
  47. Prolactin and Estrogens as Mitogens in Prostate Cancer
    Nira Ben Jonathan; Fiscal Year: 2002
    ..The findings on BPA may reveal the potential risk associated with human exposure to environmental estrogens. ..
  48. Fox Chase Cancer Center Breast Cancer Tissue Resources
    Jose Russo; Fiscal Year: 2008
    ..abstract_text> ..
  49. Conference on Tumor Induction and Progression
    Mina Bissell; Fiscal Year: 2005
    ..We need to capture more brilliant minds to enter this area. In this first Keystone meeting on tumor microenvironment, we propose to unravel the excitement and the promise of the field. ..
  50. MAMMARY CANCER PREVENTION BY CONJUGATED LINOLEIC ACID
    Clement Ip; Fiscal Year: 2007
    ..abstract_text> ..
  51. SMOOTH MUSCLE-EPITHELIAL INTERACTIONS IN PROSTATE CANCER
    Gerald Cunha; Fiscal Year: 2001
    ..In addition, it is possible that this study will identify one or more strategies for regulating the growth, differentiation and)'or invasive behavior of prostatic carcinoma cells. ..
  52. CALCIUM RECEPTOR IN MAMMARY DEVELOPMENT AND PHYSIOLOGY
    Joshua VanHouten; Fiscal Year: 2006
    ..This will be accomplished through formal course work and by interactions with the co-sponsor and collaborators. Yale is an ideal training environment, with an abundance of physical and intellectual resources. ..
  53. GENETIC AND BIOCHEMICAL DISSECTION OF PROLACTIN ACTIONS
    NELSON HORSEMAN; Fiscal Year: 2006
    ..These models will allow us to examine the role of mammary-expressed TPH in development and physiology in animals that have interruptions in their autocrine/paracrine 5-HT exposure. ..
  54. Mechanisms of Progression in c-MYC-Induced Breast Cancer
    Lewis Chodosh; Fiscal Year: 2006
    ..abstract_text> ..
  55. 4-Hydroxyestradiol Receptor in Breast Cancer
    Jose Russo; Fiscal Year: 2005
    ..This plan is in line with goals 1 and 3 of the Breast Cancer Progress Review Group to better understand the biology of the normal mammary gland and of precancerous lesions. ..
  56. Mammary Development and Breast Cancer Susceptibility
    Lewis Chodosh; Fiscal Year: 2005
    ..We anticipate that these studies will help to illuminate developmental mechanisms that contribute to the determination of breast cancer susceptibility. ..
  57. HUNK AND PUNC FUNCTION IN MAMMARY EPITHELIAL BIOLOGY
    Lewis Chodosh; Fiscal Year: 2004
    ....
  58. Stromal Epithelial Interactions in Breast Cancer
    Gerald Cunha; Fiscal Year: 2004
    ..To accomplish these goals we will use tissue recombinant technology, cell and organ culture, immunocytochemistry, and various molecular methodologies. ..
  59. ROLE OF MICROSATELLITE INSTABILITY IN BREAST CANCER
    Jose Russo; Fiscal Year: 2002
    ..The knowledge gained through this exploratory work will establish the basis for more in dept studies in the role of mismatch repair in breast cancer. ..
  60. CHEMOREPULSION MEDIATED NETRIN RECEPTORS UNC5H AND DCC
    Lindsay Hinck; Fiscal Year: 2003
    ..These experiments provide the foundation for understanding how cells translate a netrin-1 signal into directed migrations. ..
  61. Temporal Analysis of Mammary Carcinogenesis
    Lewis Chodosh; Fiscal Year: 2005
    ....
  62. SERM Regulation of PAK Pathway in Endometrial Cancer
    Rakesh Kumar; Fiscal Year: 2008
    ..abstract_text> ..
  63. Regulation of Apical Polarity in Breast Cancer
    SOPHIE LELIEVRE; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  64. Small Laboratory Animal Imaging: High Resolution Microcomputed Tomography System
    RAMIRO TORIBIO; Fiscal Year: 2006
    ..Salary and benefits for the Supervisor and Space and utilities for the instrument will be provided by Department of Veterinary Biosciences and the College of Veterinary Medicine. [unreadable] [unreadable]..
  65. PTHrP on normal osteoblast differentiation and function
    RAMIRO TORIBIO; Fiscal Year: 2008
    ..Dr. Thomas Rosol's laboratory will provide an excellent environment for developing the skills necessary to become a successful independent researcher. ..
  66. OXIDANT STRESS AND ENDOTHELIAL CELL METABOLISM
    LORRAINE SORDILLO; Fiscal Year: 2001
    ..Results form these studies will provide the molecular basis of how Se deficiency can modify resistance to metabolic vascular disorders. ..
  67. Pak1 - PIN Pathway in Breast Cancer Progression
    Rakesh Kumar; Fiscal Year: 2008
    ..Our proposed research is significant as this research might form the basis for new advances in identifying novel molecular targets, detecting, preventing and treating breast cancer, by identifying PIN as a key regulatory nodule. ..
  68. HER2 Pathway in Breast Cancer Progression and Treatment
    Rakesh Kumar; Fiscal Year: 2007
    ..abstract_text> ..
  69. Recovery of functional p53 as a therapeutic approach for breast cancer
    SALMAN HYDER; Fiscal Year: 2008
    ..Furthermore, we contend that the research will provide critical data relevant to minimizing breast cancer risk and metastasis in post-menopausal women and other women exposed to exogenous progestins. ..
  70. Mammary Carcinogenesis: Growth Hormone and IGF-I
    David Kleinberg; Fiscal Year: 2006
    ..The potential role of IGF-I as a permissive factor for the action of PRL will also be determined. ..
  71. Progestin Regulation of VEGF in Breast Cancer Cells
    SALMAN HYDER; Fiscal Year: 2005
    ..abstract_text> ..