Genomes and Genes
animal mammary glands
Summary: MAMMARY GLANDS in the non-human MAMMALS.
Publications314 found, 100 shown here
- Candidate regulators of mammary branching morphogenesis identified by genome-wide transcript analysisHosein Kouros-Mehr
Department of Anatomy, Biomedical Sciences Program, University of California, San Francisco 94143 0452, USA
Dev Dyn 235:3404-12. 2006..We discuss the potential roles of these genes in mammary branching morphogenesis...
- Generation of a functional mammary gland from a single stem cellMark Shackleton
The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
Nature 439:84-8. 2006..Our data establish that single cells within the Lin-CD29hiCD24+ population are multipotent and self-renewing, properties that define them as MaSCs...
- Gata-3 is an essential regulator of mammary-gland morphogenesis and luminal-cell differentiationMarie Liesse Asselin-Labat
VBCRC Laboratory, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
Nat Cell Biol 9:201-9. 2007..These studies provide evidence for the existence of an epithelial hierarchy within the mammary gland and establish Gata-3 as a critical regulator of luminal differentiation...
- Expression of the neu protooncogene in the mammary epithelium of transgenic mice induces metastatic diseaseC T Guy
Institute for Molecular Biology and Biotechnology, McMaster University, Hamilton, Ontario, Canada
Proc Natl Acad Sci U S A 89:10578-82. 1992..Interestingly, many of the tumor-bearing transgenic mice developed secondary metastatic tumors in the lung. These observations suggest that overexpression of the unactivated neu protein can induce metastatic disease after long latency...
- Notch signaling regulates mammary stem cell function and luminal cell-fate commitmentToula Bouras
VBCRC Laboratory, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
Cell Stem Cell 3:429-41. 2008..These findings reveal key roles for Notch signaling in MaSCs and luminal cell commitment and further suggest that inappropriate Notch activation promotes the self-renewal and transformation of luminal progenitor cells...
- WNT signals are required for the initiation of hair follicle developmentThomas Andl
Department of Dermatology, University of Pennsylvania, Philadelphia, PA 19104, USA
Dev Cell 2:643-53. 2002..This phenotype indicates that activation of WNT signaling in the skin precedes, and is required for, localized expression of regulatory genes and initiation of hair follicle placode formation...
- Stat5a is mandatory for adult mammary gland development and lactogenesisX Liu
Laboratory of Biochemistry and Metabolism, National Institute of Diabetes and Digestive and Kidney Diseases NIDDK, National Institutes of Health NIH, Bethesda, Maryland 20892 1812, USA
Genes Dev 11:179-86. 1997..These results document that Stat5a is the principal and an obligate mediator of mammopoietic and lactogenic signaling...
- GATA-3 maintains the differentiation of the luminal cell fate in the mammary glandHosein Kouros-Mehr
Department of Anatomy and the Biomedical Sciences Program, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
Cell 127:1041-55. 2006..This suggests that GATA-3 actively maintains luminal epithelial differentiation in the adult mammary gland, which raises important implications for the pathogenesis of breast cancer...
- Mice lacking progesterone receptor exhibit pleiotropic reproductive abnormalitiesJ P Lydon
Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030, USA
Genes Dev 9:2266-78. 1995..Collectively, these results provide direct support for progesterone's role as a pleiotropic coordinator of diverse reproductive events that together ensure species survival...
- Information networks in the mammary glandLothar Hennighausen
Laboratory of Genetics and Physiology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Nat Rev Mol Cell Biol 6:715-25. 2005..Steroids and simple peptide hormones initiate and carry out complex developmental programmes, and reverse genetics has been used to define the underlying mechanistic connections...
- Purification and unique properties of mammary epithelial stem cellsJohn Stingl
Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver V5Z 1L3, British Columbia, Canada
Nature 439:993-7. 2006..The mammary stem cells are also a rapidly cycling population in the normal adult and have molecular features indicative of a basal position in the mammary epithelium...
- Collective epithelial migration and cell rearrangements drive mammary branching morphogenesisAndrew J Ewald
Department of Anatomy and Program in Cell Biology, University of California, San Francisco, San Francisco, CA 94143, USA
Dev Cell 14:570-81. 2008..Significantly, we observed that normal epithelium and neoplastic hyperplasias are organized similarly, suggesting common mechanisms of epithelial growth...
- Origin and secretion of milk lipidsI H Mather
Department of Animal and Avian Sciences, University of Maryland, College Park 20742, USA
J Mammary Gland Biol Neoplasia 3:259-73. 1998..A combination of both mechanisms may be possible. Following secretion, a fraction of the membrane surrounding the globules may be shed from the droplets and give rise to membrane fragments in the skim milk phase...
- Stromal effects on mammary gland development and breast cancerBryony S Wiseman
Department of Anatomy, University of California, 513 Parnassus Avenue, San Francisco, CA 94143, USA
Science 296:1046-9. 2002..To find cures for diseases like breast cancer that rely on epithelial-stromal crosstalk, we must understand how these different cell types communicate with each other...
- Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genomeR Nusse
Cell 31:99-109. 1982..We propose that tumorigenesis by MMTV is strongly favored by proviral insertion within the int1 locus, perhaps as a consequence of enhanced expression of a novel cellular oncogene...
- Mammary gland, limb and yolk sac defects in mice lacking Tbx3, the gene mutated in human ulnar mammary syndromeTodd G Davenport
Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, 701 W 168th Street, New York, NY 10032, USA
Development 130:2263-73. 2003....
- Paracrine signaling through the epithelial estrogen receptor alpha is required for proliferation and morphogenesis in the mammary glandSonia Mallepell
National Center of Competence in Research Molecular Oncology, Swiss Institute for Experimental Cancer Research, 155 Chemin des Boveresses, CH 1066 Epalinges s Lausanne, Switzerland
Proc Natl Acad Sci U S A 103:2196-201. 2006....
- Single-step induction of mammary adenocarcinoma in transgenic mice bearing the activated c-neu oncogeneW J Muller
Harvard Medical School Department of Genetics, Boston, Massachusetts 02115
Cell 54:105-15. 1988....
- Role of FGF10/FGFR2b signaling during mammary gland development in the mouse embryoArnaud André Mailleux
UMR144 CNRS Institut Curie, 26 rue d Ulm 75248 Paris Cedex 05, France
Development 129:53-60. 2002..Our results also suggest that FGF signaling is involved in the maintenance of mammary bud 4, and that Fgf10 deficient epithelium can undergo branching morphogenesis into the mammary fat pad precursor...
- Hormonal regulation of mammary differentiation and milk secretionMargaret C Neville
Department of Physiology and Biophysics, University of Colorado Health Sciences Center, Denver 80262, USA
J Mammary Gland Biol Neoplasia 7:49-66. 2002....
- Molecular heterogeneity of breast carcinomas and the cancer stem cell hypothesisJohn Stingl
Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK
Nat Rev Cancer 7:791-9. 2007..Drawing such parallels might help to unravel the molecular nature of the initiating events in breast cancer and might have substantial clinical implications...
- Pubertal mammary gland development: insights from mouse modelsJillian Howlin
UCD School of Biomolecular and Biomedical Science, Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland, and Department of Laboratory Medicine, Malmo University Hospital, Sweden
J Mammary Gland Biol Neoplasia 11:283-97. 2006....
- The Ets transcription factor Elf5 specifies mammary alveolar cell fateSamantha R Oakes
Cancer Research Program, Garvan Institute of Medical Research, Darlinghurst, New South Wales 2010, Australia
Genes Dev 22:581-6. 2008..Thus Elf5 specifies the differentiation of CD61+ progenitors to establish the secretory alveolar lineage during pregnancy, providing a link between prolactin, transcriptional events, and alveolar development...
- Functional development of the mammary gland: use of expression profiling and trajectory clustering to reveal changes in gene expression during pregnancy, lactation, and involutionMichael C Rudolph
Department of Physiology and Biophysics, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
J Mammary Gland Biol Neoplasia 8:287-307. 2003..With progesterone withdrawal, PRL and IGF-1 signaling are activated, in turn activating Akt/PKB and the SREBPs, leading to increased lipid synthesis...
- Mammary gland development and tumorigenesis in estrogen receptor knockout miceW P Bocchinfuso
Receptor Biology Section, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
J Mammary Gland Biol Neoplasia 2:323-34. 1997..These studies provide the impetus to evaluate the effect of other oncogenes in mammary tumorigenesis in the absence of estrogen/ER signaling...
- Label-retaining epithelial cells in mouse mammary gland divide asymmetrically and retain their template DNA strandsGilbert H Smith
Laboratory of Mammary Gland Biology and Tumorigenesis, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
Development 132:681-7. 2005....
- Mammary development in the embryo and adult: a journey of morphogenesis and commitmentChristine J Watson
Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK
Development 135:995-1003. 2008..A surprising recent discovery has been that mammary epithelial cells commit to differentiated lineages using the same signalling pathways that regulate lineage determination in T helper cells...
- The osteoclast differentiation factor osteoprotegerin-ligand is essential for mammary gland developmentJ E Fata
Department of Medical Biophysics, Ontario Cancer Institute, University of Toronto, Canada
Cell 103:41-50. 2000..These data provide a novel paradigm in mammary gland development and an evolutionary rationale for hormonal regulation and gender bias of osteoporosis in females...
- Key stages in mammary gland development. Secretory activation in the mammary gland: it's not just about milk protein synthesis!Steven M Anderson
Department of Pathology, University of Colorado Health Sciences Center, East 17th Avenue, Aurora, CO 80045, USA
Breast Cancer Res 9:204. 2007....
- Targeted inactivation of the EGF and amphiregulin genes reveals distinct roles for EGF receptor ligands in mouse mammary gland developmentN C Luetteke
Department of Biochemistry and Biophysics, UNC Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7295, USA
Development 126:2739-50. 1999..Finally, the additional loss of growth factors from pups nursed by triple null dams further worsened their survival and growth, establishing functions for both maternal- and neonatal-derived growth factors...
- Metabolic regulation in the lactating mammary gland: a lipid synthesizing machineMichael C Rudolph
Department of Physiology and Biophysics, University of Colorado Health Sciences Center at Fitzsimmons, Aurora, Colorado 80045, USA
Physiol Genomics 28:323-36. 2007..They also implicate the transcription factor SREBP-1c in regulation of part of the pathway...
- ACSL1, AGPAT6, FABP3, LPIN1, and SLC27A6 are the most abundant isoforms in bovine mammary tissue and their expression is affected by stage of lactationMassimo Bionaz
Mammalian NutriPhysioGenomics, Department of Animal Sciences and Division of Nutritional Sciences, University of Illinois, Urbana, Illinois 61801, USA
J Nutr 138:1019-24. 2008..Results suggest that SLC27A6, ACSL1, FABP3, AGPAT6, and LPIN1 coordinately regulate the channeling of fatty acids toward copious milk fat synthesis in bovine mammary...
- Tissue geometry determines sites of mammary branching morphogenesis in organotypic culturesCeleste M Nelson
Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
Science 314:298-300. 2006..These results reveal that tissue geometry can control organ morphogenesis by defining the local cellular microenvironment, a finding that has relevance to control of invasion and metastasis...
- The MAPK(ERK-1,2) pathway integrates distinct and antagonistic signals from TGFalpha and FGF7 in morphogenesis of mouse mammary epitheliumJimmie E Fata
Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
Dev Biol 306:193-207. 2007..Our findings indicate that expression of morphogenetic effectors, proliferation, and cell-type decisions during mammary organoid morphogenesis are intimately dependent on the duration of activation of MAPK(ERK1,2) activation...
- Mouse embryonic mammogenesis as a model for the molecular regulation of pattern formationJacqueline M Veltmaat
UMR 144 CNRS Institut Curie, Section de Recherche, Equipe de Morphogenèse Cellulaire et Progression Tumorale, 26 Rue d Ulm, 75248 Paris Cedex 05, France
Differentiation 71:1-17. 2003..For future investigations in the field, such a unique molecular identity of each mammary rudiment should be of critical concern...
- Bovine TLR2 and TLR4 properly transduce signals from Staphylococcus aureus and E. coli, but S. aureus fails to both activate NF-kappaB in mammary epithelial cells and to quickly induce TNFalpha and interleukin-8 (CXCL8) expression in the udderWei Yang
Research Institute for the Biology of Farm Animals FBN, Wilhelm Stahl Allee 2, 18196 Dummerstorf, Germany
Mol Immunol 45:1385-97. 2008..Rather, the pathogen causing subclinical mastitis impairs NF-kappaB activation in MEC thereby severely weakening the immune response in the udder...
- Signaling pathways in mammary gland developmentL Hennighausen
Laboratory of Genetics and Physiology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 0822, USA
Dev Cell 1:467-75. 2001..Here we discuss the signaling pathways that have been adopted by the mammary gland for its own purposes, and the functions they perform...
- A plasma kallikrein-dependent plasminogen cascade required for adipocyte differentiationS Selvarajan
Department of Anatomy, Box 0452, University of California, 513 Parnasssus Avenue, San Francisco, California 94143, USA
Nat Cell Biol 3:267-75. 2001..PKal is therefore a physiological regulator that acts in the Plg cascade during adipogenesis. We propose that the Plg cascade fosters adipocyte differentiation by degradation of the fibronectin-rich preadipocyte stromal matrix...
- Effect of conditional knockout of the type II TGF-beta receptor gene in mammary epithelia on mammary gland development and polyomavirus middle T antigen induced tumor formation and metastasisElizabeth Forrester
Department of Cancer Biology, Ingram Cancer Center, Nashville, Tennessee, USA
Cancer Res 65:2296-302. 2005....
- Contribution of the ABC transporters Bcrp1 and Mdr1a/1b to the side population phenotype in mammary gland and bone marrow of miceJohan W Jonker
Division of Experimental Therapy, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
Stem Cells 23:1059-65. 2005..Interestingly, bone marrow of Mdr1a/1b-/- mice frequently displayed an elevated SP, which was reversible by the Bcrp1 inhibitor Ko143, suggesting that Bcrp1 can compensate for the loss of Mdr1a/1b in bone marrow...
- Lipopolysaccharide and lipoteichoic acid induce different innate immune responses in bovine mammary epithelial cellsYlva Strandberg
CSIRO Livestock Industries, Queensland Bioscience Precinct, 306 Carmody Road, St Lucia 4067, QLD, Australia
Cytokine 31:72-86. 2005..It was concluded that bovine mammary epithelial cells have a strong but differential capacity to mount innate immune responses to bacterial cell wall components...
- P21-activated kinase-1 phosphorylates and transactivates estrogen receptor-alpha and promotes hyperplasia in mammary epitheliumRui An Wang
Department of Molecular and Cellular Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030 4009, USA
EMBO J 21:5437-47. 2002..These findings reveal a novel role for the Pak1-ER pathway in promoting hyperplasia in mammary epithelium...
- Unique and shared functions of different connexins in miceA Plum
Institut fur Genetik, Universitat Bonn, Roemerstrasse164, D 53117, Bonn, Germany
Curr Biol 10:1083-91. 2000....
- Parity-induced mouse mammary epithelial cells are pluripotent, self-renewing and sensitive to TGF-beta1 expressionCorinne A Boulanger
Mammary Biology and Tumorigenesis Laboratory, National Cancer Institute, Bethesda, MD 20892, USA
Oncogene 24:552-60. 2005....
- Interactions between FGF and Wnt signals and Tbx3 gene expression in mammary gland initiation in mouse embryosMaxwell C Eblaghie
Division of Cell and Developmental Biology, Faculty of Life Sciences, Wellcome Trust Biocentre, University of Dundee, Scotland, UK
J Anat 205:1-13. 2004..These data, taken together with previous findings, suggest a model in which Tbx3 expression is induced and maintained in early gland initiation by both Wnt and Fgf signalling through FGFR1...
- Parity-induced mammary epithelial cells facilitate tumorigenesis in MMTV-neu transgenic miceMaLinda D Henry
Eppley Institute for Research in Cancer and Allied Diseases and the Department of Pathology and Microbiology, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, NE 68198 6805, USA
Oncogene 23:6980-5. 2004....
- Parathyroid hormone-related protein maintains mammary epithelial fate and triggers nipple skin differentiation during embryonic breast developmentJ Foley
Medical Sciences, Indiana University School of Medicine, Bloomington, IN 47405, USA
Development 128:513-25. 2001..Finally, PTHrP signaling regulates the epidermal and mesenchymal expression of LEF1 and (&bgr;)-catenin, suggesting that these changes in cell fate involve an interaction between the PTHrP and Wnt signaling pathways...
- Prolactin, growth hormone, and epidermal growth factor activate Stat5 in different compartments of mammary tissue and exert different and overlapping developmental effectsM I Gallego
Laboratory of Genetics and Physiology, National Institute of Diabetes, Digestive and Kidney Diseases, Bethesda, Maryland 20892, USA
Dev Biol 229:163-75. 2001..Our findings demonstrate that GH, Prl, and EGF activate Stat5 in separate compartments, which in turn reflects their specific roles in ductal and alveolar development and differentiation...
- Beta-casein gene promoter activity is regulated by the hormone-mediated relief of transcriptional repression and a mammary-gland-specific nuclear factorM Schmitt-Ney
Friedrich Miescher Institute, Basel, Switzerland
Mol Cell Biol 11:3745-55. 1991..The DNA sequences recognized by all five of these nuclear factors are conserved in the promoters of different casein genes from several species, confirming their importance in the regulation of milk protein gene transcription...
- Cyclin D1 provides a link between development and oncogenesis in the retina and breastP Sicinski
Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, USA
Cell 82:621-30. 1995..Thus, steroid-induced proliferation of mammary epithelium during pregnancy may be driven through cyclin D1...
- Activation of BAD by therapeutic inhibition of epidermal growth factor receptor and transactivation by insulin-like growth factor receptorAndrew P Gilmore
School of Biological Sciences, University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, United Kingdom
J Biol Chem 277:27643-50. 2002..Our results indicate that by targeting a growth factor-mediated survival signaling pathway, BAD phosphorylation can be manipulated therapeutically to induce apoptosis...
- Maternal PPAR gamma protects nursing neonates by suppressing the production of inflammatory milkYihong Wan
Howard Hughes Medical Institute, Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037, USA
Genes Dev 21:1895-908. 2007..Therefore, maternal PPAR gamma is pivotal for maintaining the quality of milk and protecting the nursing newborns by suppressing the production of inflammatory lipids in the lactating mammary gland...
- Endogenous protein kinase CK2 participates in Wnt signaling in mammary epithelial cellsD H Song
Departments of Medicine, Chemistry, and Microbiology, Boston Medical Center and Boston University, Boston, Massachusetts 02118, USA
J Biol Chem 275:23790-7. 2000..These results demonstrate that endogenous CK2 is a positive regulator of Wnt signaling and growth of mammary epithelial cells...
- Identification of immune genes and proteins involved in the response of bovine mammary tissue to Staphylococcus aureus infectionYlva C Strandberg Lutzow
Co operative Research Centre for Innovative Dairy Products, Australia
BMC Vet Res 4:18. 2008..Moreover, the effect of infection on the presence of bioactive innate immune proteins in milk is also unclear. The nature of these responses may determine the susceptibility of the tissue and its ability to resolve the infection...
- Mammary gland factor (MGF) is a novel member of the cytokine regulated transcription factor gene family and confers the prolactin responseH Wakao
Friedrich Miescher Institute, Basel, Switzerland
EMBO J 13:2182-91. 1994..Prolactin-dependent transactivation of a beta-casein promoter-luciferase reporter gene construct was observed in transfected cells...
- Cloning and expression of Stat5 and an additional homologue (Stat5b) involved in prolactin signal transduction in mouse mammary tissueX Liu
Laboratory of Biochemistry and Metabolism, National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 92:8831-5. 1995..The increase of Stat5 expression during pregnancy coincides with the activation of the WAP gene...
- Bax and Bcl-xs are induced at the onset of apoptosis in involuting mammary epithelial cellsK Heermeier
Laboratory of Biochemistry and Metabolism, National Institutes of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892 1812, USA
Mech Dev 56:197-207. 1996..These findings point to a significant role for Bax and Bcl-xS in the regulation of apoptosis of secretory alveolar cells during involution...
- Ras and TGF[beta] cooperatively regulate epithelial cell plasticity and metastasis: dissection of Ras signaling pathwaysElzbieta Janda
Institute of Molecular Pathology, A 1030 Vienna, Austria
J Cell Biol 156:299-313. 2002..Thus, EMT seems to be a close in vitro correlate of metastasis, both requiring synergism between TGFbeta-R and Raf/MAPK signaling...
- Extracellular matrix-regulated gene expression requires cooperation of SWI/SNF and transcription factorsRen Xu
Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
J Biol Chem 282:14992-9. 2007..Thus, extracellular matrix- and prolactin-regulated transcription of the mammary-specific casein genes requires the concerted action of chromatin remodeling enzymes and transcription factors...
- Prolactin regulation of mammary gland developmentSamantha R Oakes
Development Group, Cancer Research Program, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, NSW, 2010, Australia
J Mammary Gland Biol Neoplasia 13:13-28. 2008..Here we focus on providing an over-view of prolactin action during development of the model murine mammary gland...
- Identification of differentially expressed microRNAs during the development of Chinese murine mammary glandChunmei Wang
Key laboratory Dairy Science of Education Ministry Northeast Agricultural University, Harbin 15000, China
J Genet Genomics 34:966-73. 2007..These results indicate that miRNAs are functionally involved in mammary gland development...
- Prolactin controls mammary gland development via direct and indirect mechanismsC Brisken
Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02142 1479, USA
Dev Biol 210:96-106. 1999....
- Laminin mediates tissue-specific gene expression in mammary epitheliaC H Streuli
School of Biological Sciences, University of Manchester, Zurich
J Cell Biol 129:591-603. 1995..Our results demonstrate that laminin can direct tissue-specific gene expression in epithelial cells through its globular domain...
- Cooperation of signalling pathways in embryonic mammary gland developmentGertraud W Robinson
Laboratory of Genetics and Physiology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Building 8, Room 101, 8 Center Drive, Bethesda, Maryland 20892 20822, USA
Nat Rev Genet 8:963-72. 2007..Some of these signals contribute to aberrant mammary development in humans and are deregulated in cancer...
- Transcriptional profiling of mammary gland side population cellsFariba Behbod
Department of Molecular and Cellular Biology, DeBakey Building, M638a, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030 3498, USA
Stem Cells 24:1065-74. 2006..In conclusion, microarray gene profiling suggests that MG-SPs are a lineage-deficient mammary gland subpopulation expressing key genes involved in cell cycle regulation, development, and angiogenesis...
- An adjunct mammary epithelial cell population in parous females: its role in functional adaptation and tissue renewalKay Uwe Wagner
Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Rm 8009, Omaha, NE 68198 6805, USA
Development 129:1377-86. 2002..e. ductal morphogenesis and lobulogenesis). We propose that this parity-induced population contributes importantly to the biological differences between the mammary glands of parous and nulliparous females...
- Endocrine-disrupting compounds and mammary gland development: early exposure and later life consequencesSuzanne E Fenton
U S Environmental Protection Agency, ORD, National Health and Environmental Effects Research Laboratory, Reproductive Toxicology Division, MD 67, Research Triangle Park, North Carolina 27711, USA
Endocrinology 147:S18-24. 2006....
- Cellular turnover in the mammary gland is correlated with systemic levels of progesterone and not 17beta-estradiol during the estrous cycleJ E Fata
Department of Medical Biophysics, Ontario Cancer Institute, University of Toronto, 610 University Avenue, Toronto, Ontario, Canada M5G 2M9
Biol Reprod 65:680-8. 2001..We propose that the cyclical turnover of epithelial cells within the adult mammary tissue is a sum of spatial and functional coordination of hormonal and matrix regulatory factors...
- Stem cells in normal breast development and breast cancerGabriela Dontu
Department of Internal Medicine, Hematology Oncology, Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA
Cell Prolif 36:59-72. 2003..This phenotypic diversity is driven by a small subset of mammary tumour stem cells. We will discuss the important implications of this mammary tumour stem-cell model...
- Precocious mammary gland development in P-cadherin-deficient miceG L Radice
Howard Hughes Medical Institute, Center for Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
J Cell Biol 139:1025-32. 1997..Furthermore, the loss of P-cadherin from the myoepithelium has uncovered a novel function for this tissue in maintaining the undifferentiated state of the underlying secretory epithelium...
- MET and MYC cooperate in mammary tumorigenesisAlana L Welm
G W Hooper Research Foundation and Department of Microbiology and Immunology, University of California, San Francisco, CA 94143, USA
Proc Natl Acad Sci U S A 102:4324-9. 2005..The approach described here should provide a useful model with which to efficiently test effects of various genes on tumor development in the breast...
- Peroxisome proliferator-activated receptor-gamma activation and long-chain fatty acids alter lipogenic gene networks in bovine mammary epithelial cells to various extentsA K G Kadegowda
Department of Animal and Avian Sciences, University of Maryland, College Park, Maryland 20742, USA
J Dairy Sci 92:4276-89. 2009..The coordinated upregulation of lipogenic gene networks in response to ROSI and saturated LCFA offers support for PPARG activation in regulating bovine milk fat synthesis...
- Neural and mammary gland defects in ErbB4 knockout mice genetically rescued from embryonic lethalityHester Tidcombe
Division of Neurobiology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, United Kingdom
Proc Natl Acad Sci U S A 100:8281-6. 2003..However, during pregnancy, mammary lobuloalveoli fail to differentiate correctly and lactation is defective. Rescued mice also display aberrant cranial nerve architecture and increased numbers of large interneurons within the cerebellum...
- PERK-dependent regulation of lipogenesis during mouse mammary gland development and adipocyte differentiationEkaterina Bobrovnikova-Marjon
The Leonard and Madlyn Abramson Family Cancer Research Institute and Cancer Center, Philadelphia, PA 19104, USA
Proc Natl Acad Sci U S A 105:16314-9. 2008..These findings implicate PERK as a physiologically relevant regulator of the lipogenic pathway...
- p63: a novel myoepithelial cell marker in canine mammary tissuesA Gama
Department of Pathology and Veterinary Clinics, University of Trás os Montes e Alro Douro, Vila Real, Portugal
Vet Pathol 40:412-20. 2003..In conclusion, the present study reveals p63 as a sensitive and highly specific marker of myoepithelial cells in canine mammary tissues, and the authors suggest p63 as an additional marker for defining myoepithelial histogenesis...
- Constitutive activation of smoothened (SMO) in mammary glands of transgenic mice leads to increased proliferation, altered differentiation and ductal dysplasiaRicardo C Moraes
Baylor Breast Center and Department of Molecular and Cellular Biology, Room N1210 MS BCM600, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
Development 134:1231-42. 2007..Our data suggest that altered hedgehog signaling may contribute to breast cancer development by stimulating proliferation, and by increasing the pool of division-competent cells capable of anchorage-independent growth...
- Persistent changes in gene expression induced by estrogen and progesterone in the rat mammary glandM R Ginger
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030 3411, USA
Mol Endocrinol 15:1993-2009. 2001..These results provide the first support at the molecular level for the hypothesis that hormone-induced persistent changes in gene expression are present in the involuted mammary gland...
- The Pea3 Ets transcription factor regulates differentiation of multipotent progenitor cells during mammary gland developmentNatasza A Kurpios
Department of Biochemistry and Biomedical Sciences, Centre for Functional Genomics, McMaster University, Hamilton, Ontario, Canada
Dev Biol 325:106-21. 2009..We propose that Pea3 functions in multipotential progenitors to regulate their lineage-specific differentiation potential...
- Comparison of steroid receptor expression in normal, dysplastic, and neoplastic canine and feline mammary tissuesF Millanta
Department of Animal Pathology, School of Veterinary Medicine, University of Pisa, Viale delle Piagge, 2, I 56124 Pisa, Italy
Res Vet Sci 79:225-32. 2005..The low percentage of ER-positive invasive carcinomas further demonstrated the aggressive phenotype and behaviour of feline mammary tumours...
- RANK-L and RANK: T cells, bone loss, and mammalian evolutionLars E Theill
Inflammation Drug Discovery Research, One Amgen Center Drive, Thousand Oaks, California 91320 1789, USA
Annu Rev Immunol 20:795-823. 2002..Modulation of these systems provides us with a unique opportunity to design novel therapeutics to inhibit bone loss in arthritis, periodontal disease, and osteoporosis...
- Invasive potential induced under long-term oxidative stress in mammary epithelial cellsKazunori Mori
Department of Microbiology, Showa University School of Pharmaceutical Sciences, Tokyo, Japan
Cancer Res 64:7464-72. 2004....
- Defective mammary gland morphogenesis in mice lacking the progesterone receptor B isoformBiserka Mulac-Jericevic
Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
Proc Natl Acad Sci U S A 100:9744-9. 2003....
- RANK overexpression in transgenic mice with mouse mammary tumor virus promoter-controlled RANK increases proliferation and impairs alveolar differentiation in the mammary epithelia and disrupts lumen formation in cultured epithelial aciniEva Gonzalez-Suarez
Department of Cancer Biology, AW2 D2262, Amgen Inc, 1201 Amgen Court West, Seattle, WA 98119, USA
Mol Cell Biol 27:1442-54. 2007..Moreover, the increased proliferation and survival observed in a three-dimensional culture system suggests a role for aberrant RANK signaling during breast tumorigenesis...
- A developmental atlas of rat mammary gland histologyP A Masso-Welch
Roswell Park Cancer Institute, Buffalo, New York, USA
J Mammary Gland Biol Neoplasia 5:165-85. 2000..The purpose of this review is to assist researchers in recognizing histological changes in the epithelium and stroma of the rat mammary gland throughout development...
- The housekeeping gene xanthine oxidoreductase is necessary for milk fat droplet enveloping and secretion: gene sharing in the lactating mammary glandClaudia Vorbach
Howard Hughes Medical Institute, Department of Human Genetics, University of Utah, Salt Lake City 84112, USA
Genes Dev 16:3223-35. 2002..About 5% of women experience primary lactation insufficiency. The above observations suggest that human females suffering from xanthinuria, a deficiency in XOR, are potential candidates for lactation problems...
- Differential mammary morphogenesis along the anteroposterior axis in Hoxc6 gene targeted miceA Garcia-Gasca
Center for Molecular and Structural Biology, Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina 29403, USA
Dev Dyn 219:261-76. 2000..The position-specific phenotypes observed and the potential role for Hoxc6 in mediating hormone-regulated ductal expansion and regression in the adult female are discussed...
- Progesterone signaling and mammary gland morphogenesisG Shyamala
Division of Life Sciences, Lawrence Berkeley National Laboratory, University of California, Berkeley 94720, USA
J Mammary Gland Biol Neoplasia 4:89-104. 1999....
- Reducing mammary cancer risk through premature stem cell senescenceC A Boulanger
Laboratory of Tumor Immunology and Biology, National Cancer Institute, Bethesda, Maryland, MD 20892, USA
Oncogene 20:2264-72. 2001..The results suggest a positive correlation between the procreative life-span of mammary epithelial stem cells and mammary cancer risk...
- WNT/beta-catenin mediates radiation resistance of mouse mammary progenitor cellsWendy A Woodward
Department of Radiation Oncology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Proc Natl Acad Sci U S A 104:618-23. 2007..These data demonstrate that, compared with differentiated cells, progenitor cells have different cell survival properties that may facilitate the development of targeted antiprogenitor cell therapies...
- Epithelial development and differentiation in the mammary gland is not dependent on alpha 3 or alpha 6 integrin subunitsT C Klinowska
School of Biological Sciences, University of Manchester, 3 239 Stopford Building, Oxford Road, Manchester, M13 9PT, United Kingdom
Dev Biol 233:449-67. 2001..This work demonstrates that mammary tissue genetically lacking major laminin-binding integrin receptors is still able to develop and function...
- Genetic manipulation of mammary epithelium by transplantationP A Edwards
Department of Pathology, University of Cambridge, U K
J Mammary Gland Biol Neoplasia 1:75-89. 1996..Insights into normal development have also been obtained by inappropriate expression of genes such as Wnt-4...
- Insulin-like growth factor-II regulates PTEN expression in the mammary glandRoger A Moorehead
Ontario Cancer Institute University Health Network, University of Toronto, Toronto, Ontario M5G 2M9, Canada
J Biol Chem 278:50422-7. 2003..Thus, we have identified a novel negative feedback loop within the PI3K pathway where IGF-II induces PTEN expression to modulate its physiologic effects...
- Expression of a truncated Brca1 protein delays lactational mammary development in transgenic miceMelissa A Brown
Department of Medical and Molecular Genetics, King s College London, Guy s Hospital, UK
Transgenic Res 11:467-78. 2002..They may also have implications for germline carriers of BRCA1 mutations...
- Cattle mammary bioreactor generated by a novel procedure of transgenic cloning for large-scale production of functional human lactoferrinPenghua Yang
State Key Laboratory for Agrobiotechnology, China Agricultural University, Beijing, People s Republic of China
PLoS ONE 3:e3453. 2008..Moreover, the cattle mammary bioreactors generated with this novel procedure produce functional rhLF on an industrial scale...
- Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formationX Xu
Genetics of Development and Disease Branch, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Nat Genet 22:37-43. 1999..Our results demonstrate that disruption of Brca1 causes genetic instability and triggers further alterations, including the inactivation of p53, that lead to tumour formation...
- Next stop, the twilight zone: hedgehog network regulation of mammary gland developmentMichael T Lewis
Baylor College of Medicine, Houston, Texas 77030, USA
J Mammary Gland Biol Neoplasia 9:165-81. 2004..Further, studies suggest a role for misregulated network function in the progression of breast cancer...
- Innate immune response to intramammary infection with Serratia marcescens and Streptococcus uberisDouglas D Bannerman
Bovine Functional Genomics Laboratory, Beltsville Agricultural Research Center, USDA Agricultural Research Service, Beltsville, MD 20705, USA
Vet Res 35:681-700. 2004..marcescens infection. Together, these data demonstrate the variability of the innate immune response to two distinct mastitis pathogens...
- Signalling pathways implicated in early mammary gland morphogenesis and breast cancerBeatrice Howard
University College London, United Kingdom
PLoS Genet 2:e112. 2006..Reflecting this intimate connection, a considerable number of signalling pathways have been implicated in both mammary gland morphogenesis and carcinogenesis...
- Targeted disruption of beta1-integrin in a transgenic mouse model of human breast cancer reveals an essential role in mammary tumor inductionDonald E White
Department of Medical Sciences, McMaster University, Hamilton, Ontario, L8S 4K1, Canada
Cancer Cell 6:159-70. 2004..These observations provide a direct demonstration that beta1-integrin plays a critical role in both the initiation and maintenance of mammary tumor growth in vivo...
- Mammary gland development in adult mice requires epithelial and stromal estrogen receptor alphaStefan O Mueller
Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
Endocrinology 143:2357-65. 2002..Immunostaining for ER alpha and PR in the mammary outgrowths supported the view that both stromal and epithelial ER alpha, in cooperation with epithelial PR, govern mammary gland development in adult mice...
- Escherichia coli, but not Staphylococcus aureus triggers an early increased expression of factors contributing to the innate immune defense in the udder of the cowWolfram Petzl
Clinic for Ruminants, Ludwig Maximilians University, Munich, Germany
Vet Res 39:18. 2008..Using the established mastitis model, the data clearly demonstrate a pathogen-dependent difference in the time kinetics of induced pathogen receptors and defense molecules...
- IGF-1 Receptor Signaling in Mammary Gland DevelopmentDarryl Hadsell; Fiscal Year: 2006..abstract_text> ..
- PROGESTERONE RECEPTORS IN MAMMARY DEVELOPMENT/NEOPLASIAG Shyamala; Fiscal Year: 2001....
- P53 AND MOUSE MAMMARY TUMORIGENESISDaniel Medina; Fiscal Year: 2004..In summary, this model allows one to analyze the biological, genetic and molecular consequences of p53 gene deletion in the in situ mammary gland by taking advantage of transplantation methods. ..
- BIOLOGY OF NEOPLASTIC TRANSFORMATION IN BREAST CANCERRobert Cardiff; Fiscal Year: 2005..The goal of this project is to develop a well-characterized model for breast cancer development and to dissect the molecular pathways involved in tumor formation. ..
- GORDON RESEARCH CONFERENCE ON MAMMARY GLAND BIOLOGYMARY BARCELLOS HOFF; Fiscal Year: 2003..abstract_text> ..
- MECHANISMS OF THE HORMONAL PREVENTION OF BREAST CANCERDaniel Medina; Fiscal Year: 2006..The molecular understanding of the fundamental biological events involved in hormone-induced growth and differentiation will provide a rationale for developing new approaches for preventing human breast cancer. ..
- ROLE OF STROMA IN MAMMARY GLAND CELL PROLIFERATIONSANDRA HASLAM; Fiscal Year: 2007..The long-term goal of this proposal is the delineation of the mechanisms of P-dependent growth regulation in the adult normal mammary gland that may lead to novel strategies for the prevention and treatment of breast cancer. ..
- PRECLINICAL MODELS OF BREAST CANCERRobert Cardiff; Fiscal Year: 2003..The theme of the workshop is "High Throughput Phenotyping: From Mouse to Molecule in One Day!" It will allow the student to examine and compare the best and fastest phenotyping technology currently available. ..
- 25TH IABCR CONGRESS CONFERENCE: PERSONALIZED BREAST CANCER THERAPYRobert Cardiff; Fiscal Year: 2006..The session will also include a plenary lecture from Dr. A Ullrich who pioneered the concept of targeting the HER2 oncogene in the treatment of breast cancer. [unreadable] [unreadable] [unreadable] [unreadable]..
- In Utero Mammary Cancer Risk with Resveratrol and TCDDCORAL LAMARTINIERE; Fiscal Year: 2008..Programming breast cancer chemoprevention from in utero exposure to a nutritional agent would be a novel breakthrough for women's health. [unreadable] [unreadable] [unreadable]..
- LACTATIONAL EFFECTORS OF TRIACYLGLYCEROL MOBILIZATIONJAMES MCMANAMAN; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- In Utero TCDD Programming for Mammary CancerCORAL LAMARTINIERE; Fiscal Year: 2005..abstract_text> ..
- Soy and Estrogen Interactions in the BreastJ Cline; Fiscal Year: 2009..The proposed work will provide a unique view of an otherwise inaccessible period of breast development in a primate model with high genetic and physiologic similarity to human beings. ..
- PHYSIOLOGICAL FACTORS AFFECTING HUMAN LACTATIONMargaret Neville; Fiscal Year: 2002....
- Effects of Dietary Soy on Biomarkers in Prostate CancerJ Cline; Fiscal Year: 2004..abstract_text> ..
- Genistein Impriting Against Prostate CancerCORAL LAMARTINIERE; Fiscal Year: 2003..We propose this in a dietary model at "physiological concentrations." ..
- Genomic Markers of Breast Cancer Prevention Induced by hCG in Women at High RiskJose Russo; Fiscal Year: 2008..This knowledge will serve as the basis for establishing novel genomic signatures as intermediate biomarkers for larger preventive clinical trials at the completion of this project. [unreadable] [unreadable] [unreadable]..
- Genomic Basis of Reproductive History on Breast CancerJose Russo; Fiscal Year: 2006..abstract_text> ..
- Prenatal xenoestrogen exposure and mammary cancerANA SOTO; Fiscal Year: 2006..It may even influence public policy about prevention. ..
- Xenoestrogens: Genomic and Non-genomic MechanismsNira Ben Jonathan; Fiscal Year: 2006..The results of these studies should provide much needed experimental foundation for assessing the vulnerability of the pituitary gland to insults by endocrine disruptors. ..
- Molecular biomarkers of selenium chemopreventionClement Ip; Fiscal Year: 2006..The goal is to broaden our understanding of the significance of clonal suppression of early transformed cells in selenium protection of cancer. ..
- In utero dietary exposure to endocrine disruptorsLeena Hilakivi Clarke; Fiscal Year: 2007..unreadable] [unreadable]..
- P53-dependent responses to toxicants in parous and nulliparous breastD Joseph Jerry; Fiscal Year: 2010....
- NR4A Nuclear Receptor Function in LeukemiaOrla M Conneely; Fiscal Year: 2010..abstract_text> ..
- Genetic modifiers of mammary tumor susceptibilityD Jerry; Fiscal Year: 2009..Identificationofgenes thatmodifysusceptibilitytomammarytumors willprovidemarkers for riskassessment andnovel targets for therapeutic intervention. ..
- Epigenetic Changes Induced by Estrogens and Xenoestrogens in Breast CancerJose Russo; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- In Vitro Synthesis of Fibrosis GenesisCELESTE NELSON; Fiscal Year: 2008..We present here a three-dimensional, microlithography-based model that can be used to break down the key steps involved in the earliest stages of fibrosis genesis. [unreadable] [unreadable] [unreadable]..
- PROGESTERONE RECEPTOR A AND B PROTEINS IN REPRODUCTIONORLA CONNEELY; Fiscal Year: 2008..abstract_text> ..
- Perinatal xenoestrogen exposure: epigenesis and neoplasiaANA SOTO; Fiscal Year: 2007..This will also have a great impact on the way we study risk factors and conduct epidemiological studies; it may even influence public policy about breast cancer prevention. [unreadable] [unreadable] [unreadable] [unreadable]..
- Selenium molecular signaling in human prostate cancerClement Ip; Fiscal Year: 2007..Aim 4 is to study the transcriptional control of GADD153 by selenium. The proposed research is thus designed to examine systemically the impact of GADD153 induction as a result of selenium treatment. ..
- Pregnancy Estrogens, Diet, and Breast Cancer RiskLeena Hilakivi Clarke; Fiscal Year: 2005..abstract_text> ..
- SELENIUM AND LUNG CANCER RISKHenry Thompson; Fiscal Year: 2004..In addition, this work has the potential to provide new biomarkers with which to assess lung cancer risk and its modulation. ..
- NEONATAL EFFECTS AND METABOLISM OF XENOESTROGENSNira Ben Jonathan; Fiscal Year: 2003..The results should provide a much needed experimental foundation for assessing the vulnerability of the neuroendocrine system to insults by environmental factors. ..
- Profiling Modifications of p53 by Mass SpectrometryD Jerry; Fiscal Year: 2003..Optimized procedures will be applied to human tumors to determine the patterns of post-translational modifications by MALDI-ToF. ..
- 12th International ISD Conference: Cancer & DevelopmentMina Bissell; Fiscal Year: 2002..abstract_text> ..
- CELL CELL INTERACTIONS IN PROSTATE CANCERGerald Cunha; Fiscal Year: 2001..These studies should define critical cellular and molecular pathways in both normal and tumorigenic growth of the prostate, and should provide the biological basis of new therapeutic strategies. ..
- PROSTATE CELL PROLIFERATION IN CANCER AND AGINGANA SOTO; Fiscal Year: 2005..We expect that this research will lead to the development of markers to identify this phenotype, and to the development of specific therapeutic strategies. ..
- GORDON CONFERENCE ON ENVIRONMENTAL ENDOCRINE DISRUPTORSANA SOTO; Fiscal Year: 2002..abstract_text> ..
- Role of PAX2 in Mammary Development and CancerGARY SILBERSTEIN; Fiscal Year: 2005..Finally, the possibility that PAX2 is a mammary tumor promoter will be evaluated, providing insights into mechanisms of breast cancer progression. ..
- PROTEIN KINASES IN YEAST DNA CHECKPOINT PATHWAYSDavid Stern; Fiscal Year: 2009..Aim 3. Molecular techniques will be used for functional analysis of NFBD1/MDC1 in the activities identified in Aim 2. ..
- CANCER PREVENTION BY SELENIUM-ENRICHED ALLIUM VEGETABLESClement Ip; Fiscal Year: 2003..The objective is to corroborate the significance of clonal suppression of preneoplastic lesions in selenium protection of cancer. ..
- HETEROSPECIFIC CELL/CELL INTERACTIONS IN PROSTATE GROWTHGerald Cunha; Fiscal Year: 2001..Concepts derived from the analysis of basic cellular mechanisms of prostatic growth will be applied to the pathogenesis of BPH. ..
- BRCA2 FUNCTION IN MAMMARY EPITHELIAL BIOLOGYLewis Chodosh; Fiscal Year: 2002..We will also determine whether Brca2 is posttranslationally modified following DNA damage in a manner similar to that observed for Brca1. Finally, we will determine whether Brca2 and Brca1 interact during these processes. ..
- DEFINITION OF MICROENVIRONMENT IN BREAST CANCERMina Bissell; Fiscal Year: 2008..As loss of appropriate integration of these signals could lead to malignancy, our results may yield new markers and therapeutic strategies to limit or reverse breast tumor progression. ..
- Timing of dietary exposure and breast cancer riskLeena Hilakivi Clarke; Fiscal Year: 2008..This program aims to develop novel means to prevent some breast cancers by dietary modifications that take place during pregnancy and puberty. ..
- LACTOSE SYNTHESIS REGULATION: ROLE OF GLUCOSE TRANSPORTPETER HANEY; Fiscal Year: 2002..These will be related to changes in glucose transport activity an lactose synthesis that are essential for milk production. ..
- Prolactin and Estrogens as Mitogens in Prostate CancerNira Ben Jonathan; Fiscal Year: 2002..The findings on BPA may reveal the potential risk associated with human exposure to environmental estrogens. ..
- Fox Chase Cancer Center Breast Cancer Tissue ResourcesJose Russo; Fiscal Year: 2008..abstract_text> ..
- Conference on Tumor Induction and ProgressionMina Bissell; Fiscal Year: 2005..We need to capture more brilliant minds to enter this area. In this first Keystone meeting on tumor microenvironment, we propose to unravel the excitement and the promise of the field. ..
- MAMMARY CANCER PREVENTION BY CONJUGATED LINOLEIC ACIDClement Ip; Fiscal Year: 2007..abstract_text> ..
- SMOOTH MUSCLE-EPITHELIAL INTERACTIONS IN PROSTATE CANCERGerald Cunha; Fiscal Year: 2001..In addition, it is possible that this study will identify one or more strategies for regulating the growth, differentiation and)'or invasive behavior of prostatic carcinoma cells. ..
- CALCIUM RECEPTOR IN MAMMARY DEVELOPMENT AND PHYSIOLOGYJoshua VanHouten; Fiscal Year: 2006..This will be accomplished through formal course work and by interactions with the co-sponsor and collaborators. Yale is an ideal training environment, with an abundance of physical and intellectual resources. ..
- GENETIC AND BIOCHEMICAL DISSECTION OF PROLACTIN ACTIONSNELSON HORSEMAN; Fiscal Year: 2006..These models will allow us to examine the role of mammary-expressed TPH in development and physiology in animals that have interruptions in their autocrine/paracrine 5-HT exposure. ..
- Mechanisms of Progression in c-MYC-Induced Breast CancerLewis Chodosh; Fiscal Year: 2006..abstract_text> ..
- 4-Hydroxyestradiol Receptor in Breast CancerJose Russo; Fiscal Year: 2005..This plan is in line with goals 1 and 3 of the Breast Cancer Progress Review Group to better understand the biology of the normal mammary gland and of precancerous lesions. ..
- Mammary Development and Breast Cancer SusceptibilityLewis Chodosh; Fiscal Year: 2005..We anticipate that these studies will help to illuminate developmental mechanisms that contribute to the determination of breast cancer susceptibility. ..
- HUNK AND PUNC FUNCTION IN MAMMARY EPITHELIAL BIOLOGYLewis Chodosh; Fiscal Year: 2004....
- Stromal Epithelial Interactions in Breast CancerGerald Cunha; Fiscal Year: 2004..To accomplish these goals we will use tissue recombinant technology, cell and organ culture, immunocytochemistry, and various molecular methodologies. ..
- ROLE OF MICROSATELLITE INSTABILITY IN BREAST CANCERJose Russo; Fiscal Year: 2002..The knowledge gained through this exploratory work will establish the basis for more in dept studies in the role of mismatch repair in breast cancer. ..
- CHEMOREPULSION MEDIATED NETRIN RECEPTORS UNC5H AND DCCLindsay Hinck; Fiscal Year: 2003..These experiments provide the foundation for understanding how cells translate a netrin-1 signal into directed migrations. ..
- Temporal Analysis of Mammary CarcinogenesisLewis Chodosh; Fiscal Year: 2005....
- SERM Regulation of PAK Pathway in Endometrial CancerRakesh Kumar; Fiscal Year: 2008..abstract_text> ..
- Regulation of Apical Polarity in Breast CancerSOPHIE LELIEVRE; Fiscal Year: 2006..unreadable] [unreadable] [unreadable]..
- Small Laboratory Animal Imaging: High Resolution Microcomputed Tomography SystemRAMIRO TORIBIO; Fiscal Year: 2006..Salary and benefits for the Supervisor and Space and utilities for the instrument will be provided by Department of Veterinary Biosciences and the College of Veterinary Medicine. [unreadable] [unreadable]..
- PTHrP on normal osteoblast differentiation and functionRAMIRO TORIBIO; Fiscal Year: 2008..Dr. Thomas Rosol's laboratory will provide an excellent environment for developing the skills necessary to become a successful independent researcher. ..
- OXIDANT STRESS AND ENDOTHELIAL CELL METABOLISMLORRAINE SORDILLO; Fiscal Year: 2001..Results form these studies will provide the molecular basis of how Se deficiency can modify resistance to metabolic vascular disorders. ..
- Pak1 - PIN Pathway in Breast Cancer ProgressionRakesh Kumar; Fiscal Year: 2008..Our proposed research is significant as this research might form the basis for new advances in identifying novel molecular targets, detecting, preventing and treating breast cancer, by identifying PIN as a key regulatory nodule. ..
- HER2 Pathway in Breast Cancer Progression and TreatmentRakesh Kumar; Fiscal Year: 2007..abstract_text> ..
- Recovery of functional p53 as a therapeutic approach for breast cancerSALMAN HYDER; Fiscal Year: 2008..Furthermore, we contend that the research will provide critical data relevant to minimizing breast cancer risk and metastasis in post-menopausal women and other women exposed to exogenous progestins. ..
- Mammary Carcinogenesis: Growth Hormone and IGF-IDavid Kleinberg; Fiscal Year: 2006..The potential role of IGF-I as a permissive factor for the action of PRL will also be determined. ..
- Progestin Regulation of VEGF in Breast Cancer CellsSALMAN HYDER; Fiscal Year: 2005..abstract_text> ..