animal mammary glands

Summary

Summary: MAMMARY GLANDS in the non-human MAMMALS.

Top Publications

  1. ncbi Candidate regulators of mammary branching morphogenesis identified by genome-wide transcript analysis
    Hosein Kouros-Mehr
    Department of Anatomy, Biomedical Sciences Program, University of California, San Francisco 94143-0452, USA
    Dev Dyn 235:3404-12. 2006
  2. ncbi Signaling pathways in mammary gland development
    L Hennighausen
    Laboratory of Genetics and Physiology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 0822, USA
    Dev Cell 1:467-75. 2001
  3. ncbi Cooperation of signalling pathways in embryonic mammary gland development
    Gertraud W Robinson
    Laboratory of Genetics and Physiology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Building 8, Room 101, 8 Center Drive, Bethesda, Maryland 20892 20822, USA
    Nat Rev Genet 8:963-72. 2007
  4. ncbi An adjunct mammary epithelial cell population in parous females: its role in functional adaptation and tissue renewal
    Kay Uwe Wagner
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Rm 8009, Omaha, NE 68198 6805, USA
    Development 129:1377-86. 2002
  5. ncbi Transcriptional profiling of mammary gland side population cells
    Fariba Behbod
    Department of Molecular and Cellular Biology, DeBakey Building, M638a, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030-3498, USA
    Stem Cells 24:1065-74. 2006
  6. ncbi Constitutive activation of smoothened (SMO) in mammary glands of transgenic mice leads to increased proliferation, altered differentiation and ductal dysplasia
    Ricardo C Moraes
    Baylor Breast Center and Department of Molecular and Cellular Biology, Room N1210 MS BCM600, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Development 134:1231-42. 2007
  7. ncbi Invasive potential induced under long-term oxidative stress in mammary epithelial cells
    Kazunori Mori
    Department of Microbiology, Showa University School of Pharmaceutical Sciences, Tokyo, Japan
    Cancer Res 64:7464-72. 2004
  8. ncbi Defective mammary gland morphogenesis in mice lacking the progesterone receptor B isoform
    Biserka Mulac-Jericevic
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 100:9744-9. 2003
  9. ncbi RANK overexpression in transgenic mice with mouse mammary tumor virus promoter-controlled RANK increases proliferation and impairs alveolar differentiation in the mammary epithelia and disrupts lumen formation in cultured epithelial acini
    Eva Gonzalez-Suarez
    Department of Cancer Biology, AW2 D2262, Amgen Inc, 1201 Amgen Court West, Seattle, WA 98119, USA
    Mol Cell Biol 27:1442-54. 2007
  10. ncbi Mammary development in the embryo and adult: a journey of morphogenesis and commitment
    Christine J Watson
    Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK
    Development 135:995-1003. 2008

Research Grants

  1. MTA1 IN ONCOGENESIS
    Rakesh Kumar; Fiscal Year: 2010
  2. Progestin Actions in the Primate Breast and Uterus
    Charles Wood; Fiscal Year: 2007
  3. IGF-1 Receptor Signaling in Mammary Gland Development
    Darryl Hadsell; Fiscal Year: 2006
  4. Breast Cancer and the Environment Research Center
    SANDRA HASLAM; Fiscal Year: 2007
  5. BIOLOGY OF NEOPLASTIC TRANSFORMATION IN BREAST CANCER
    Robert Cardiff; Fiscal Year: 2005
  6. STROMA AND MAMMARY GLAND CELL PROLIFERATION
    SANDRA HASLAM; Fiscal Year: 2000
  7. MECHANISMS OF THE HORMONAL PREVENTION OF BREAST CANCER
    Daniel Medina; Fiscal Year: 2006
  8. PRECLINICAL MODELS OF BREAST CANCER
    Robert Cardiff; Fiscal Year: 2003
  9. P53 AND MOUSE MAMMARY TUMORIGENESIS
    Daniel Medina; Fiscal Year: 2004
  10. GORDON RESEARCH CONFERENCE ON MAMMARY GLAND BIOLOGY
    MARY BARCELLOS HOFF; Fiscal Year: 2003

Detail Information

Publications224 found, 100 shown here

  1. ncbi Candidate regulators of mammary branching morphogenesis identified by genome-wide transcript analysis
    Hosein Kouros-Mehr
    Department of Anatomy, Biomedical Sciences Program, University of California, San Francisco 94143-0452, USA
    Dev Dyn 235:3404-12. 2006
    ..We discuss the potential roles of these genes in mammary branching morphogenesis...
  2. ncbi Signaling pathways in mammary gland development
    L Hennighausen
    Laboratory of Genetics and Physiology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 0822, USA
    Dev Cell 1:467-75. 2001
    ..Here we discuss the signaling pathways that have been adopted by the mammary gland for its own purposes, and the functions they perform...
  3. ncbi Cooperation of signalling pathways in embryonic mammary gland development
    Gertraud W Robinson
    Laboratory of Genetics and Physiology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Building 8, Room 101, 8 Center Drive, Bethesda, Maryland 20892 20822, USA
    Nat Rev Genet 8:963-72. 2007
    ..Some of these signals contribute to aberrant mammary development in humans and are deregulated in cancer...
  4. ncbi An adjunct mammary epithelial cell population in parous females: its role in functional adaptation and tissue renewal
    Kay Uwe Wagner
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Rm 8009, Omaha, NE 68198 6805, USA
    Development 129:1377-86. 2002
    ..e. ductal morphogenesis and lobulogenesis). We propose that this parity-induced population contributes importantly to the biological differences between the mammary glands of parous and nulliparous females...
  5. ncbi Transcriptional profiling of mammary gland side population cells
    Fariba Behbod
    Department of Molecular and Cellular Biology, DeBakey Building, M638a, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030-3498, USA
    Stem Cells 24:1065-74. 2006
    ..In conclusion, microarray gene profiling suggests that MG-SPs are a lineage-deficient mammary gland subpopulation expressing key genes involved in cell cycle regulation, development, and angiogenesis...
  6. ncbi Constitutive activation of smoothened (SMO) in mammary glands of transgenic mice leads to increased proliferation, altered differentiation and ductal dysplasia
    Ricardo C Moraes
    Baylor Breast Center and Department of Molecular and Cellular Biology, Room N1210 MS BCM600, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Development 134:1231-42. 2007
    ..Our data suggest that altered hedgehog signaling may contribute to breast cancer development by stimulating proliferation, and by increasing the pool of division-competent cells capable of anchorage-independent growth...
  7. ncbi Invasive potential induced under long-term oxidative stress in mammary epithelial cells
    Kazunori Mori
    Department of Microbiology, Showa University School of Pharmaceutical Sciences, Tokyo, Japan
    Cancer Res 64:7464-72. 2004
    ....
  8. ncbi Defective mammary gland morphogenesis in mice lacking the progesterone receptor B isoform
    Biserka Mulac-Jericevic
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 100:9744-9. 2003
    ....
  9. ncbi RANK overexpression in transgenic mice with mouse mammary tumor virus promoter-controlled RANK increases proliferation and impairs alveolar differentiation in the mammary epithelia and disrupts lumen formation in cultured epithelial acini
    Eva Gonzalez-Suarez
    Department of Cancer Biology, AW2 D2262, Amgen Inc, 1201 Amgen Court West, Seattle, WA 98119, USA
    Mol Cell Biol 27:1442-54. 2007
    ..Moreover, the increased proliferation and survival observed in a three-dimensional culture system suggests a role for aberrant RANK signaling during breast tumorigenesis...
  10. ncbi Mammary development in the embryo and adult: a journey of morphogenesis and commitment
    Christine J Watson
    Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK
    Development 135:995-1003. 2008
    ..A surprising recent discovery has been that mammary epithelial cells commit to differentiated lineages using the same signalling pathways that regulate lineage determination in T helper cells...
  11. ncbi Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation
    X Xu
    Genetics of Development and Disease Branch, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Genet 22:37-43. 1999
    ..Our results demonstrate that disruption of Brca1 causes genetic instability and triggers further alterations, including the inactivation of p53, that lead to tumour formation...
  12. ncbi RANK-L and RANK: T cells, bone loss, and mammalian evolution
    Lars E Theill
    Inflammation Drug Discovery Research, One Amgen Center Drive, Thousand Oaks, California 91320-1789, USA
    Annu Rev Immunol 20:795-823. 2002
    ..Modulation of these systems provides us with a unique opportunity to design novel therapeutics to inhibit bone loss in arthritis, periodontal disease, and osteoporosis...
  13. ncbi Innate immune response to intramammary infection with Serratia marcescens and Streptococcus uberis
    Douglas D Bannerman
    Bovine Functional Genomics Laboratory, Beltsville Agricultural Research Center, USDA Agricultural Research Service, Beltsville, MD 20705, USA
    Vet Res 35:681-700. 2004
    ..marcescens infection. Together, these data demonstrate the variability of the innate immune response to two distinct mastitis pathogens...
  14. ncbi Next stop, the twilight zone: hedgehog network regulation of mammary gland development
    Michael T Lewis
    Baylor College of Medicine, Houston, Texas 77030, USA
    J Mammary Gland Biol Neoplasia 9:165-81. 2004
    ..Further, studies suggest a role for misregulated network function in the progression of breast cancer...
  15. ncbi Parathyroid hormone-related protein maintains mammary epithelial fate and triggers nipple skin differentiation during embryonic breast development
    J Foley
    Medical Sciences, Indiana University School of Medicine, Bloomington, IN 47405, USA
    Development 128:513-25. 2001
    ..Finally, PTHrP signaling regulates the epidermal and mesenchymal expression of LEF1 and (&bgr;)-catenin, suggesting that these changes in cell fate involve an interaction between the PTHrP and Wnt signaling pathways...
  16. ncbi Stromal effects on mammary gland development and breast cancer
    Bryony S Wiseman
    Department of Anatomy, University of California, 513 Parnassus Avenue, San Francisco, CA 94143, USA
    Science 296:1046-9. 2002
    ..To find cures for diseases like breast cancer that rely on epithelial-stromal crosstalk, we must understand how these different cell types communicate with each other...
  17. ncbi A novel effect of dioxin: exposure during pregnancy severely impairs mammary gland differentiation
    Beth A Vorderstrasse
    Department of Pharmaceutical Sciences, Washington State University, Pullman, Washington 99164, USA
    Toxicol Sci 78:248-57. 2004
    ....
  18. ncbi Expression of the neu protooncogene in the mammary epithelium of transgenic mice induces metastatic disease
    C T Guy
    Institute for Molecular Biology and Biotechnology, McMaster University, Hamilton, Ontario, Canada
    Proc Natl Acad Sci U S A 89:10578-82. 1992
    ..Interestingly, many of the tumor-bearing transgenic mice developed secondary metastatic tumors in the lung. These observations suggest that overexpression of the unactivated neu protein can induce metastatic disease after long latency...
  19. ncbi Protein kinase CK2 in mammary gland tumorigenesis
    E Landesman-Bollag
    Department of Medicine, Boston Medical Center, Boston, Massachusetts, MA 02118 2394, USA
    Oncogene 20:3247-57. 2001
    ..Thus, in mice, rats, and humans, dysregulated expression of CK2 is associated with and is capable of contributing to mammary tumorigenesis. Targeted inhibition of CK2 could be useful in the treatment of breast cancer...
  20. ncbi Vitamin D receptor (VDR) ablation alters carcinogen-induced tumorigenesis in mammary gland, epidermis and lymphoid tissues
    Glendon M Zinser
    Department of Biological Sciences, University of Notre Dame, 214 Galvin Life Sciences Building, Notre Dame, IN 46556, USA
    J Steroid Biochem Mol Biol 97:153-64. 2005
    ..These data indicate that VDR ablation alters susceptibility to DMBA-induced carcinogenesis in a tissue specific fashion, and provide support that optimal VDR signaling may act to suppress tumorigenesis...
  21. ncbi Collective epithelial migration and cell rearrangements drive mammary branching morphogenesis
    Andrew J Ewald
    Department of Anatomy and Program in Cell Biology, University of California, San Francisco, San Francisco, CA 94143, USA
    Dev Cell 14:570-81. 2008
    ..Significantly, we observed that normal epithelium and neoplastic hyperplasias are organized similarly, suggesting common mechanisms of epithelial growth...
  22. ncbi Adhesion-mediated signaling in the regulation of mammary epithelial cell survival
    C H Streuli
    School of Biological Sciences, University of Manchester, United Kingdom
    J Mammary Gland Biol Neoplasia 4:183-91. 1999
    ..In this review we consider the molecular mechanisms by which cell-matrix interactions contribute to cell survival, and discuss their role in mammary gland development and function...
  23. ncbi Tbx3, the ulnar-mammary syndrome gene, and Tbx2 interact in mammary gland development through a p19Arf/p53-independent pathway
    Loydie A Jerome-Majewska
    Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Dev Dyn 234:922-33. 2005
    ....
  24. ncbi Parathyroid hormone-related protein signaling is necessary for sexual dimorphism during embryonic mammary development
    M E Dunbar
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520 8020, USA
    Development 126:3485-93. 1999
    ..We propose that PTHrP expression specifically within the developing epithelial bud acts as a dominant signal participating in cell fate decisions leading to a specialized mammary mesenchyme...
  25. ncbi Mammary involution in dairy animals
    A V Capuco
    Gene Evaluation and Mapping Laboratory, USDA ARS, Beltsville, Maryland 20705, USA
    J Mammary Gland Biol Neoplasia 4:137-44. 1999
    ..The ability to manipulate apoptosis and cell proliferation during the nonlactating period and during lactation is expected to provide enormous benefits to the dairy industry...
  26. ncbi Development of mammary luminal progenitor cells is controlled by the transcription factor STAT5A
    Daisuke Yamaji
    Laboratory of Genetics and Physiology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Genes Dev 23:2382-7. 2009
    ..Thus, STAT5A is necessary and sufficient for the establishment of luminal progenitor cells...
  27. ncbi Insulin-mediated acceleration of breast cancer development and progression in a nonobese model of type 2 diabetes
    Ruslan Novosyadlyy
    Division of Endocrinology, Diabetes and Bone Diseases, The Samuel Bronfman Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Cancer Res 70:741-51. 2010
    ..Our findings offer compelling experimental evidence that T2D accelerates mammary gland development and carcinogenesis,and that the IR and/or the IGF-IR are major mediators of these effects...
  28. ncbi Functional culture models to study mechanisms governing apoptosis in normal and malignant mammary epithelial cells
    V M Weaver
    Life Sciences Division, Lawrence Berkeley National Laboratory, University of California, Berkeley 94720, USA
    J Mammary Gland Biol Neoplasia 4:193-201. 1999
    ..These models could now be used to investigate how the basement membrane represses apoptosis in normal cells, and how breast cancers become death-resistant...
  29. ncbi Tumour necrosis factor-alpha (TNF-alpha) increases nuclear factor kappaB (NFkappaB) activity in and interleukin-8 (IL-8) release from bovine mammary epithelial cells
    D C Fitzgerald
    UCD School of Agriculture, Food Science and Veterinary Medicine, University College Dublin, Belfield, Dublin 4, Ireland
    Vet Immunol Immunopathol 116:59-68. 2007
    ..These data support a role for TNF-alpha in activation of NFkappaB and release of IL-8 from bovine mammary epithelial cells...
  30. ncbi Regulation of mammary gland branching morphogenesis by EphA2 receptor tyrosine kinase
    David Vaught
    Department of Cancer Biology, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Mol Biol Cell 20:2572-81. 2009
    ..Together, these data demonstrate a positive role for EphA2 during normal mammary epithelial proliferation and branching morphogenesis...
  31. ncbi C/EBPbeta (CCAAT/enhancer binding protein) controls cell fate determination during mammary gland development
    T N Seagroves
    Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030 3498, USA
    Mol Endocrinol 14:359-68. 2000
    ....
  32. ncbi Clinical parameters for assessment of udder health in Danish dairy herds
    H Houe
    Department of Animal Science and Animal Health, The Royal Veterinary and Agricultural University, Frederiksberg, Denmark
    Acta Vet Scand 43:173-84. 2002
    ..It is further concluded that certain combinations of extended clinical recordings have significant perspectives for future characterisation of udder health...
  33. ncbi Transforming growth factor beta signaling impairs Neu-induced mammary tumorigenesis while promoting pulmonary metastasis
    Peter M Siegel
    Cell Biology Program and Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 100:8430-5. 2003
    ....
  34. ncbi Gata-3 is an essential regulator of mammary-gland morphogenesis and luminal-cell differentiation
    Marie Liesse Asselin-Labat
    VBCRC Laboratory, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
    Nat Cell Biol 9:201-9. 2007
    ..These studies provide evidence for the existence of an epithelial hierarchy within the mammary gland and establish Gata-3 as a critical regulator of luminal differentiation...
  35. ncbi Src activation is not necessary for transforming growth factor (TGF)-beta-mediated epithelial to mesenchymal transitions (EMT) in mammary epithelial cells. PP1 directly inhibits TGF-beta receptors I and II
    Masato Maeda
    Department of Oral Biology, College of Dentistry, University of Nebraska Medical Center, Nebraska Medical Center, Omaha 68198-7696, USA
    J Biol Chem 281:59-68. 2006
    ..Taken together, our data indicated that PP1 interferes with TGF-beta1-mediated EMT not by inhibiting Src family kinases but by inhibiting the Smad pathway via a direct inhibition of TGF-beta receptor kinase activity...
  36. ncbi NF-kappaB is essential for epithelial-mesenchymal transition and metastasis in a model of breast cancer progression
    Margit A Huber
    Department of Physiological Chemistry, Ulm University, Albert-Einstein-Allee 11, D-89081 Ulm, Germany
    J Clin Invest 114:569-81. 2004
    ....
  37. ncbi Activated type I TGFbeta receptor kinase enhances the survival of mammary epithelial cells and accelerates tumor progression
    R S Muraoka-Cook
    Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN 37232 6307, USA
    Oncogene 25:3408-23. 2006
    ....
  38. ncbi Matrix metalloproteinases and the regulation of tissue remodelling
    Andrea Page-McCaw
    Department of Biology and Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, New York 12180, USA
    Nat Rev Mol Cell Biol 8:221-33. 2007
    ..Recent studies in mice and flies point to essential roles of MMPs as mediators of change and physical adaptation in tissues, whether developmentally regulated, environmentally induced or disease associated...
  39. ncbi Shh expression is required for embryonic hair follicle but not mammary gland development
    Kinga Michno
    Department of Laboratory Medicine, University of Toronto, Toronto, Ontario, Canada
    Dev Biol 264:153-65. 2003
    ..Furthermore, these data suggest that cyclin D1 expression in the embryonic hair follicle is mediated by both Hh-independent and Hh-dependent mechanisms...
  40. ncbi TGF-beta, c-Cbl, and PDGFR-alpha the in mammary stroma
    Michael R Crowley
    The Department of Cell Biology, The University of Alabama at Birmingham, 1918 University Boulevard 310, MCLM, Birmingham, AL 35294, USA
    Dev Biol 279:58-72. 2005
    ..Finally, the effects of PDGF-AA on branching were determined. Treatment in vivo with PDGF-AA did not affect branching making a functional interaction between TGF-beta and PDGF unlikely...
  41. ncbi Lipid synthesis in lactation: diet and the fatty acid switch
    Michael C Rudolph
    Department of Pathology, University of Colorado Health Sciences Center, Anschutz Medical Campus, 12801 East 17th Avenue, Mail Stop 8104, P O Box 6511, Aurora, CO 80045, USA
    J Mammary Gland Biol Neoplasia 12:269-81. 2007
    ..These regulatory pathways may be critical to the production of milk with a balanced TAG composition to support neonatal development of the newborn...
  42. ncbi Identification of immune genes and proteins involved in the response of bovine mammary tissue to Staphylococcus aureus infection
    Ylva C Strandberg Lutzow
    Co operative Research Centre for Innovative Dairy Products, Australia
    BMC Vet Res 4:18. 2008
    ..Moreover, the effect of infection on the presence of bioactive innate immune proteins in milk is also unclear. The nature of these responses may determine the susceptibility of the tissue and its ability to resolve the infection...
  43. ncbi The mouse mammary gland requires the actin-binding protein gelsolin for proper ductal morphogenesis
    M R Crowley
    Division of Experimental Pathology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, New York 14263, USA
    Dev Biol 225:407-23. 2000
    ..Our results provide the first evidence of an actin regulatory protein affecting mammary ductal growth through stromal-epithelial communication...
  44. ncbi The osteoclast differentiation factor osteoprotegerin-ligand is essential for mammary gland development
    J E Fata
    Department of Medical Biophysics, Ontario Cancer Institute, University of Toronto, Canada
    Cell 103:41-50. 2000
    ..These data provide a novel paradigm in mammary gland development and an evolutionary rationale for hormonal regulation and gender bias of osteoporosis in females...
  45. ncbi Lactation defect in mice lacking the helix-loop-helix inhibitor Id2
    S Mori
    Department of Molecular Genetics, Kyoto University Graduate School of Medicine, Shogoin Kawahara cho 53, Sakyo ku, Kyoto 606 8507, Japan
    EMBO J 19:5772-81. 2000
    ..A decrease in the DNA binding activity of Stat5 was also observed in Id2(-/-) mammary glands at 7 days post-coitus. Our results indicate an indispensable role of Id2 in pregnant mammary glands...
  46. ncbi The spatial and temporal expression of the alpha 2 beta 1 integrin and its ligands, collagen I, collagen IV, and laminin, suggest important roles in mouse mammary morphogenesis
    P J Keely
    Department of Pathology, Washington University School of Medicine, St Louis, MO 63110 1093, USA
    Differentiation 59:1-13. 1995
    ..Our results suggest that alpha 2 beta 1 integrin interactions with its temporally and spatially regulated ligands, collagen I, collagen IV, and laminin, could play an important role in mammary morphogenesis in vivo...
  47. ncbi TNFalpha induces NFkappaB/p50 in association with the growth and morphogenesis of normal and transformed rat mammary epithelial cells
    L M Varela
    Department of Pharmacology and Therapeutics, Grace Cancer Drug Center, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    J Cell Physiol 188:120-31. 2001
    ..In addition, the significant increase in NFkappaB/p50 DNA-binding was temporally coincident with TNFalpha-induced growth and morphogenesis, suggesting that it may play a significant role in both normal development and carcinogenesis...
  48. ncbi Cellular turnover in the mammary gland is correlated with systemic levels of progesterone and not 17beta-estradiol during the estrous cycle
    J E Fata
    Department of Medical Biophysics, Ontario Cancer Institute, University of Toronto, 610 University Avenue, Toronto, Ontario, Canada M5G 2M9
    Biol Reprod 65:680-8. 2001
    ..We propose that the cyclical turnover of epithelial cells within the adult mammary tissue is a sum of spatial and functional coordination of hormonal and matrix regulatory factors...
  49. ncbi Expression of a 74-kDa nuclear factor 1 (NF1) protein is induced in mouse mammary gland involution. Involution-enhanced occupation of a twin NF1 binding element in the testosterone-repressed prostate message-2/clusterin promoter
    E E Furlong
    Department of Pharmacology and Biotechnology Center, University College Dublin, Dublin 4, Ireland
    J Biol Chem 271:29688-97. 1996
    ....
  50. ncbi Colony stimulating factor-1 is required to recruit macrophages into the mammary gland to facilitate mammary ductal outgrowth
    Andrew Van Nguyen
    Department of Developmental and Molecular Biology, Center for the Study of Reproductive Biology and Women s Health, Albert Einstein College of Medicine, 1300 Morris Park, New York, New York, 10461, USA
    Dev Biol 247:11-25. 2002
    ..These data show that macrophages acting locally are required for branching morphogenesis of the mammary gland...
  51. ncbi Notch signaling regulates mammary stem cell function and luminal cell-fate commitment
    Toula Bouras
    VBCRC Laboratory, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
    Cell Stem Cell 3:429-41. 2008
    ..These findings reveal key roles for Notch signaling in MaSCs and luminal cell commitment and further suggest that inappropriate Notch activation promotes the self-renewal and transformation of luminal progenitor cells...
  52. ncbi Response to somatic cell count-based selection for mastitis resistance in a divergent selection experiment in sheep
    R Rupp
    Institut National de la Recherche Agronomique, Castanet Tolosan, France
    J Dairy Sci 92:1203-19. 2009
    ....
  53. ncbi Mammary gland, limb and yolk sac defects in mice lacking Tbx3, the gene mutated in human ulnar mammary syndrome
    Todd G Davenport
    Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, 701 W 168th Street, New York, NY 10032, USA
    Development 130:2263-73. 2003
    ....
  54. ncbi High tumor incidence and activation of the PI3K/AKT pathway in transgenic mice define AIB1 as an oncogene
    Maria I Torres-Arzayus
    Division of Molecular and Cellular Oncology, Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Cancer Cell 6:263-74. 2004
    ..Knockdown of AIB1 expression in cultured AIB1-tg mammary tumor cells leads to reduced IGF-I mRNA levels and increased apoptosis, suggesting that an autocrine IGF-I loop underlies the mechanism of AIB1-induced oncogenesis...
  55. ncbi WNT signals are required for the initiation of hair follicle development
    Thomas Andl
    Department of Dermatology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Dev Cell 2:643-53. 2002
    ..This phenotype indicates that activation of WNT signaling in the skin precedes, and is required for, localized expression of regulatory genes and initiation of hair follicle placode formation...
  56. ncbi Escherichia coli and Staphylococcus aureus elicit differential innate immune responses following intramammary infection
    Douglas D Bannerman
    Bovine Functional Genomics Laboratory, USDA Agricultural Research Service ANRI, BARC East, Bldg 1040, Room 2, Beltsville, MD 20705 2350, USA
    Clin Diagn Lab Immunol 11:463-72. 2004
    ..coli and S. aureus and suggest that the limited cytokine response to S. aureus may contribute to the well-known ability of the bacterium to establish chronic intramammary infection...
  57. ncbi Activation of the Erk pathway is required for TGF-beta1-induced EMT in vitro
    Lu Xie
    Vanderbilt-Ingram Cancer Center, 2220 Pierce Avenue South, Vanderbilt University, Nashville, TN 37232, USA
    Neoplasia 6:603-10. 2004
    ..These data show that TGF-beta1 induces the activation of the Erk signaling pathway, which is required for TGF-beta1-mediated EMT in vitro...
  58. ncbi Sca-1(pos) cells in the mouse mammary gland represent an enriched progenitor cell population
    Bryan E Welm
    Program in Cell and Molecular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77035, USA
    Dev Biol 245:42-56. 2002
    ..Finally, the Sca-1(pos) population is enriched for functional stem/progenitor cells, as demonstrated by its increased regenerative potential compared with Sca-1(neg) cells when transplanted into the cleared mammary fat pads of host mice...
  59. ncbi Gestational PFOA exposure of mice is associated with altered mammary gland development in dams and female offspring
    Sally S White
    Curriculum in Toxicology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Toxicol Sci 96:133-44. 2007
    ..These findings suggest that in addition to gestational exposure, abnormal lactational development of dams may play a role in early growth retardation of developmentally exposed offspring...
  60. ncbi Gene networks driving bovine milk fat synthesis during the lactation cycle
    Massimo Bionaz
    Mammalian NutriPhysioGenomics, Department of Animal Sciences and Division of Nutritional Sciences, University of Illinois, Urbana, 61801 Illinois, USA
    BMC Genomics 9:366. 2008
    ..mRNA expression was coupled with milk fatty acid (FA) composition and calculated indexes of FA desaturation and de novo synthesis by the mammary gland...
  61. ncbi Mammary hyperplasia and carcinoma in MMTV-cyclin D1 transgenic mice
    T C Wang
    Department of Medicine, Massachusetts General Hospital, Boston 02114
    Nature 369:669-71. 1994
    ..We conclude that overexpression of cyclin D1 deregulates cell proliferation and can induce tumorigenic changes in mammary tissues, suggesting that cyclin D1 indeed plays an important oncogenic role in breast cancer...
  62. ncbi Pattern of distribution of cells positive for estrogen receptor alpha and progesterone receptor in relation to proliferating cells in the mammary gland
    J Russo
    Breast Cancer Research Laboratory, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Breast Cancer Res Treat 53:217-27. 1999
    ....
  63. ncbi Copper transport during lactation in transgenic mice expressing the human ATP7A protein
    Roxana M Llanos
    Centre for Cellular and Molecular Biology, School of Life and Environmental Sciences, Deakin University, 221 Burwood Hwy, Burwood, VIC 3125, Australia
    Biochem Biophys Res Commun 372:613-7. 2008
    ..These data suggest that ATP7A plays a role in removing excess copper from the mammary epithelial cells rather than supplying copper to milk...
  64. ncbi Evaluation of continuous lactation and increased milking frequency on milk production and mammary cell turnover in primiparous Holstein cows
    A C Fitzgerald
    Monsanto Company, St Louis, MO 63167, USA
    J Dairy Sci 90:5483-9. 2007
    ..Bovine somatotropin did not alter MEC turnover in primiparous CM or control glands. The use of increased milking frequency and bST alleviated, but did not prevent, reductions in milk yield of CM primiparous cows...
  65. ncbi [Nuclear organization and expression of milk protein genes]
    Eric Chanat
    Unité Génomique et Physiologie de la Lactation, Institut National de la Recherche Agronomique, Domaine de Vilvert, 78352 Jouy en Josas Cedex, France
    J Soc Biol 200:181-92. 2006
    ..Our goal is to make some progress into the understanding of the molecular and cellular mechanisms involved in the formation of these milk products...
  66. ncbi Effect of continuous milking and bovine somatotropin supplementation on mammary epithelial cell turnover
    E L Annen
    Department of Animal Sciences, University of Arizona, Tucson 85721, USA
    J Dairy Sci 90:165-83. 2007
    ..Results indicate that CM reduced subsequent half-udder milk yield in primiparous cows through altered MEC turnover and secretory capacity. Negative effects of CM on the subsequent lactation were not alleviated by bST supplementation...
  67. ncbi Efficacy of blanket treatment of cows and heifers with an internal teat sealant in reducing the risk of mastitis in dairy cattle calving on pasture
    R A Laven
    Institute of Veterinary, Animal and Biomedical Sciences, Massey University, Private Bag 11222, Palmerston North, New Zealand
    N Z Vet J 56:171-5. 2008
    ....
  68. ncbi Associations among body condition score, body weight, somatic cell count, and clinical mastitis in seasonally calving dairy cattle
    D P Berry
    Teagasc, Moorepark Dairy Production Research Centre, Fermoy, Co Cork, Ireland
    J Dairy Sci 90:637-48. 2007
    ..Results are important in assuring the public that modern dairy systems, where cows are subjected to substantial amounts of BCS mobilization in early lactation, do not unduly compromise cow udder health...
  69. ncbi Distinct roles of the three Akt isoforms in lactogenic differentiation and involution
    Ioanna G Maroulakou
    Molecular Oncology Research Institute, Tufts Medical Center, Boston, Massachusetts, USA
    J Cell Physiol 217:468-77. 2008
    ..We conclude that the three Akt isoforms have different roles in mammary gland differentiation during pregnancy and this may reflect differences in hormonal signaling...
  70. ncbi Continuous lactation in dairy cows: effect on milk production and mammary nutrient supply and extraction
    T G Madsen
    Department of Basic Animal and Veterinary Sciences, Faculty of Life Sciences, University of Copenhagen, Grønnegaardsvej 7, DK 1870 Frederiksberg C, Denmark
    J Dairy Sci 91:1791-801. 2008
    ..Milk protein content was elevated by 0.4 percentage units in the continuously milked cows. The underlying reason is unknown, but given the current pricing system for milk, it deserves to be further investigated...
  71. ncbi The calcium-sensing receptor regulates plasma membrane calcium adenosine triphosphatase isoform 2 activity in mammary epithelial cells: a mechanism for calcium-regulated calcium transport into milk
    Joshua N VanHouten
    Section of Endocrinology and Metabolism, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520 8020, USA
    Endocrinology 148:5943-54. 2007
    ....
  72. ncbi Effect of continuous milking and prostaglandin E2 on milk production and mammary epithelial cell turnover, ultrastructure, and gene expression
    E L Annen
    Department of Animal Sciences, University of Arizona, Tucson 85721, USA
    J Anim Sci 86:1132-44. 2008
    ..Reduced MEC turnover and milk yield were not alleviated by IMI of PGE(2), which indicates that peripartum PGE(2) concentrations in CM glands are not limiting mammary growth or milk synthesis...
  73. ncbi Mammary epithelial-specific deletion of the focal adhesion kinase gene leads to severe lobulo-alveolar hypoplasia and secretory immaturity of the murine mammary gland
    Tamas Nagy
    Department of Molecular Medicine, Cornell University, Ithaca, New York 14853, USA
    J Biol Chem 282:31766-76. 2007
    ..Together, these results provide strong support for a role of FAK in the mammary gland development and function in vivo...
  74. ncbi Risk factors for peripartum mastitis in pasture-grazed dairy heifers
    C W R Compton
    Animal Health Centre, PO Box 21, Morrinsville 3340, New Zealand
    J Dairy Sci 90:4171-80. 2007
    ....
  75. ncbi Effects of periparturient systemic treatment with penethamate hydriodide on udder health and milk yield of dairy heifers
    Martina Kreiger
    Clinic for Ruminants, Department for Farm Animals and Herd Management, Veterinary University of Vienna, Austria
    J Dairy Res 74:392-8. 2007
    ..Periparturient antibiotic treatment of heifers with penethamate hydriodide prevented IMI during the first week after parturition and achieved a significant increase in milk yield, which was found to be economically beneficial...
  76. ncbi Inactivation of VEGF in mammary gland epithelium severely compromises mammary gland development and function
    Heidemarie Rossiter
    Department of Dermatology, Medical University of Vienna, Waehringer GuerA 1090 Vienna, Austria
    FASEB J 21:3994-4004. 2007
    ....
  77. ncbi The tammar wallaby and fur seal: models to examine local control of lactation
    A J Brennan
    Cooperative Research Centre CRC for Innovative Dairy Products, Department of Zoology, University of Melbourne, Victoria, 3010, Australia
    J Dairy Sci 90:E66-75. 2007
    ..Therefore, we propose that a loss of function of this protein in eutherians may relate to a reproductive strategy that is less dependent on lactation...
  78. ncbi Alveolar progenitor cells develop in mouse mammary glands independent of pregnancy and lactation
    Brian W Booth
    Mammary Biology and Tumorigenesis Laboratory, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Cell Physiol 212:729-36. 2007
    ....
  79. ncbi Prepartum milking of heifers influences future production and health
    K J Daniels
    Department of Animal Sciences, Purdue University, West Lafayette, IN 47907, USA
    J Dairy Sci 90:2293-301. 2007
    ..These results indicate that prepartum milking is an alternative management practice that has beneficial effects on the production, health, and well-being of first-lactation cows...
  80. ncbi Comparison of the efficacy of cloxacillin alone and cloxacillin combined with an internal teat sealant for dry-cow therapy
    H T Newton
    School of Veterinary Science, University of Bristol, Langford, Bristol BS40 5DU
    Vet Rec 162:678-84. 2008
    ....
  81. ncbi Effects of intramammary infusions of interleukin-8 on milk protein composition and induction of acute-phase protein in cows during mammary involution
    Atsushi Watanabe
    Hokkaido Research Station, National Institute of Animal Health, Sapporo 062 0045, Japan
    Can J Vet Res 72:291-6. 2008
    ..In the cows infused with 25 microg of rbIL-8, the rectal temperature and serum haptoglobin level were transiently elevated after the infusion, showing that intramammary infusion of rbIL-8 could elicit systemic inflammation...
  82. ncbi Metabolism and udder health at dry-off in cows of different breeds and production levels
    M O Odensten
    Department of Animal Nutrition and Management, Swedish University of Agricultural Sciences, SE 753 23 Uppsala, Sweden
    J Dairy Sci 90:1417-28. 2007
    ..A prolonged CI did not facilitate a rapid decrease in milk production. The SRB and SH breeds responded equally in decreasing the milk production during DO, but the SRB breed had lower somatic cell counts...
  83. ncbi Adherence and efficacy of an external teat sealant to prevent new intramammary infections in the dry period
    G H Lim
    Department of Population Medicine, Ontario Veterinary College, Guelph, Ontario, Canada N1G 2W1
    J Dairy Sci 90:1289-300. 2007
    ..Double sealant application, cooler seasons, and longer teat lengths were associated with a significant increase in the duration of sealant adherence to the teat-end...
  84. ncbi Targeted expression of GLI1 in the mammary gland disrupts pregnancy-induced maturation and causes lactation failure
    Marie Fiaschi
    Department of Bioscience and Nutrition, Karolinska Institutet, Novum, SE 141 57 Huddinge, Sweden
    J Biol Chem 282:36090-101. 2007
    ..Taken together the data support the notion that correct regulation of Hedgehog signaling within the epithelial cell compartment is critical for pregnancy-induced mammary gland development and remodeling...
  85. ncbi Local over-expression of prolactin in differentiating mouse mammary gland induces functional defects and benign lesions, but no carcinoma
    Caroline Manhes
    Inserm Unit 808, Faculté de Médecine Descartes Paris 5 site Necker, 156 rue de Vaugirard, Paris 75015, France
    J Endocrinol 190:271-85. 2006
    ..This deserves further investigations on the emerging concept that autocrine PRL may have different effects on pathological development of the mammary gland depending on the differentiation state of the latter...
  86. ncbi Butyrophilin, an apical plasma membrane-associated glycoprotein characteristic of lactating mammary glands of diverse species
    H W Heid
    Biochim Biophys Acta 728:228-38. 1983
    ..0. We suggest that this fragment contains a membrane-spanning peptide sequence and is involved in the attachment of the cytoplasmic coat to the membrane of the milk lipid globule...
  87. ncbi Thrice-daily milking throughout lactation maintains epithelial integrity and thereby improves milk protein quality
    B A Sorensen
    Hannah Research Institute, Ayr, UK
    J Dairy Res 68:15-25. 2001
    ....
  88. ncbi A lipoprotein-containing particle is transferred from the serum across the mammary epithelium into the milk of lactating mice
    J Monks
    Department of Physiology and Biophysics, Division of Endocrinology, Metabolism and Diabetes, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Lipid Res 42:686-96. 2001
    ..An apoB-containing particle from which the cholesterol has been removed is transferred into milk...
  89. ncbi Vesicular transport of soluble substances into mouse milk
    J Monks
    Department of Physiology, University of Colorado Health Sciences Center, Denver 80262, USA
    Adv Exp Med Biol 501:257-63. 2001
    ..Using these markers and immunostaining for endogenous proteins, we have visualized transcytotic vesicles involved in transporting these markers to milk...
  90. ncbi Genetic manipulation of the IGF-I axis to regulate mammary gland development and function
    D L Hadsell
    Children s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
    J Dairy Sci 85:365-77. 2002
    ..Data from our laboratory on the expression of IGF-signaling molecules in the mammary gland suggest that this effect of physiological context may be related to the expression of members of the insulin receptor substrate family...
  91. ncbi Relationships among severity and duration of clinical mastitis and sire transmitting abilities for somatic cell score, udder type traits, productive life, and protein yield
    D L Nash
    Department of Dairy and Animal Science, The Pennsylvania State University, University Park 16802, USA
    J Dairy Sci 85:1273-84. 2002
    ..Selection for lower somatic cell score may reduce the severity and duration of clinical episodes from environmental organisms during first lactation...
  92. ncbi Perturbation of beta1-integrin function in involuting mammary gland results in premature dedifferentiation of secretory epithelial cells
    Marisa M Faraldo
    Unité Mixte Recherche 144, Centre National de la Recherche Scientifique Institut Curie, Section de Recherche, 75248 Paris, France
    Mol Biol Cell 13:3521-31. 2002
    ....
  93. ncbi The effect of an intramammary teat seal on new intramammary infections
    E A Berry
    Institute for Animal Health, Compton, Berkshire, United Kingdom
    J Dairy Sci 85:2512-20. 2002
    ..The results will inform those restricting their use of antibiotic dry cow therapy in alternative management strategies and the additional risk of new intramammary infection...
  94. ncbi Overexpression and forced activation of stat5 in mammary gland of transgenic mice promotes cellular proliferation, enhances differentiation, and delays postlactational apoptosis
    Elena Iavnilovitch
    Institute of Animal Science, ARO, The Volcani Center, Bet Dagan, Israel
    Mol Cancer Res 1:32-47. 2002
    ..It identifies Stat5 as a multifunctional regulator of mammary cell proliferation, milk protein gene expression, and postlactational apoptosis...
  95. ncbi Hyperplasia and impaired involution in the mammary gland of transgenic mice expressing human FGF4
    M Morini
    Unita Transgenici, Istituto Nazionale per la Ricerca sul Cancro, Genova, Italy
    Oncogene 19:6007-14. 2000
    ..Our work represents the first in-vivo demonstration of the anti-apoptotic and angiogenic properties of FGF4...
  96. ncbi Targeted inhibition of osteopontin expression in the mammary gland causes abnormal morphogenesis and lactation deficiency
    M Nemir
    Department of Biology, McGill University, Montreal, Quebec H3A 1B1, Canada
    J Biol Chem 275:969-76. 2000
    ..Taken together, our results demonstrate, for the first time, an essential role of OPN in mammary gland differentiation and that the molecular mechanism(s) of its action, at least in part, involves down-regulation of MMP-2...
  97. ncbi Ectopic TGF beta 1 expression in the secretory mammary epithelium induces early senescence of the epithelial stem cell population
    E C Kordon
    Laboratory of Tumor Immunology and Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 1750
    Dev Biol 168:47-61. 1995
    ....
  98. ncbi Extracellular matrix regulates whey acidic protein gene expression by suppression of TGF-alpha in mouse mammary epithelial cells: studies in culture and in transgenic mice
    C Q Lin
    Life Science Division, Lawrence Berkeley Laboratories, Berkeley, California 94720, USA
    J Cell Biol 129:1115-26. 1995
    ..These results provide a clear example of cooperation among lactogenic hormones, ECM, and locally acting growth factors in regulation of tissue-specific gene expression...
  99. ncbi Expression analysis of the individual bovine beta-, alpha s2- and kappa-casein genes in transgenic mice
    M Rijnkels
    Medical Biotechnology Department, Leiden Institute of Chemistry, Leiden University, The Netherlands
    Biochem J 311:929-37. 1995
    ..This indicates that regulatory elements required for high-level, mammary gland-specific expression are not present in the alpha s2- and kappa-casein clones used in this study and are probably located elsewhere in the casein gene locus...
  100. ncbi Expression of stromelysin-1 and TIMP-1 in the involuting mammary gland and in early invasive tumors of the mouse
    F Li
    Laboratory for Clinical and Experimental Research, Berne, Switzerland
    Int J Cancer 59:560-8. 1994
    ..Thus, expression of stromelysin-1 and TIMP-1 is confined to the aggressively growing tumors and is induced in the earliest stages of carcinogenesis...
  101. ncbi Regulation of human protein C gene expression by the mouse WAP promoter
    R K Paleyanda
    Holland Laboratory, American Red Cross, Rockville, MD 20855
    Transgenic Res 3:335-43. 1994
    ..We suggest that the inefficient intracellular processing of rHPC can alter the histological appearance of alveolar epithelial cells in the transgenic mammary gland...

Research Grants156 found, 100 shown here

  1. MTA1 IN ONCOGENESIS
    Rakesh Kumar; Fiscal Year: 2010
    ..The proposal is designed to establish the mechanism by which MTA1 contributes to the development of tumorigenic phenotypes in mammary epithelial cells and tumors. ..
  2. Progestin Actions in the Primate Breast and Uterus
    Charles Wood; Fiscal Year: 2007
    ..This work will have immediate public health relevance to postmenopausal women seeking the safest form of hormone therapy. ..
  3. IGF-1 Receptor Signaling in Mammary Gland Development
    Darryl Hadsell; Fiscal Year: 2006
    ..abstract_text> ..
  4. Breast Cancer and the Environment Research Center
    SANDRA HASLAM; Fiscal Year: 2007
    ..abstract_text> ..
  5. BIOLOGY OF NEOPLASTIC TRANSFORMATION IN BREAST CANCER
    Robert Cardiff; Fiscal Year: 2005
    ..The goal of this project is to develop a well-characterized model for breast cancer development and to dissect the molecular pathways involved in tumor formation. ..
  6. STROMA AND MAMMARY GLAND CELL PROLIFERATION
    SANDRA HASLAM; Fiscal Year: 2000
    ....
  7. MECHANISMS OF THE HORMONAL PREVENTION OF BREAST CANCER
    Daniel Medina; Fiscal Year: 2006
    ..The molecular understanding of the fundamental biological events involved in hormone-induced growth and differentiation will provide a rationale for developing new approaches for preventing human breast cancer. ..
  8. PRECLINICAL MODELS OF BREAST CANCER
    Robert Cardiff; Fiscal Year: 2003
    ..The theme of the workshop is "High Throughput Phenotyping: From Mouse to Molecule in One Day!" It will allow the student to examine and compare the best and fastest phenotyping technology currently available. ..
  9. P53 AND MOUSE MAMMARY TUMORIGENESIS
    Daniel Medina; Fiscal Year: 2004
    ..In summary, this model allows one to analyze the biological, genetic and molecular consequences of p53 gene deletion in the in situ mammary gland by taking advantage of transplantation methods. ..
  10. GORDON RESEARCH CONFERENCE ON MAMMARY GLAND BIOLOGY
    MARY BARCELLOS HOFF; Fiscal Year: 2003
    ..abstract_text> ..
  11. 25TH IABCR CONGRESS CONFERENCE: PERSONALIZED BREAST CANCER THERAPY
    Robert Cardiff; Fiscal Year: 2006
    ..The session will also include a plenary lecture from Dr. A Ullrich who pioneered the concept of targeting the HER2 oncogene in the treatment of breast cancer. ..
  12. ROLE OF STROMA IN MAMMARY GLAND CELL PROLIFERATION
    SANDRA HASLAM; Fiscal Year: 2007
    ..The long-term goal of this proposal is the delineation of the mechanisms of P-dependent growth regulation in the adult normal mammary gland that may lead to novel strategies for the prevention and treatment of breast cancer. ..
  13. SELENIUM AND MAMMARY TUMORIGENESIS
    Daniel Medina; Fiscal Year: 1993
    ....
  14. STROMA AND MAMMARY GLAND CELL PROLIFERATION
    SANDRA HASLAM; Fiscal Year: 1993
    ....
  15. ROLE OF STROMA IN MAMMARY GLAND CELL PROLIFERATION
    SANDRA HASLAM; Fiscal Year: 1992
    ..The long term goal of these studies is to elucidate the biological basis of hormone independence and provide a rationale for treatment of hormone independent human mammary cancer...
  16. NuMA function in nonmalignant and malignant breast cells
    SOPHIE LELIEVRE; Fiscal Year: 2009
    ..Thus, it is time to emphasize the role of structural nuclear proteins in gene transcription in order to get a complete picture of gene expression control. ..
  17. HER2 Pathway in Breast Cancer Progression and Treatment
    Rakesh Kumar; Fiscal Year: 2006
    ..abstract_text> ..
  18. Regulation of Cellular Zn Redistribution: A Role of ZnT2
    Shannon L Kelleher; Fiscal Year: 2010
    ..Thus, this application has significance for improving public health outcomes and advancing our understanding of basic cellular mechanisms. ..
  19. Role of Metastatic Tumor Antigen-1 in Mammary Gland
    Rakesh Kumar; Fiscal Year: 2006
    ..abstract_text> ..
  20. NuMA function in nonmalignant and malignant breast cells
    SOPHIE A LELIEVRE; Fiscal Year: 2010
    ..Thus, it is time to emphasize the role of structural nuclear proteins in gene transcription in order to get a complete picture of gene expression control. ..
  21. Regulation of Cellular Zn Redistribution: A Role of ZnT2
    Shannon L Kelleher; Fiscal Year: 2010
    ..Thus, this application has significance for improving public health outcomes and advancing our understanding of basic cellular mechanisms. ..
  22. Small Laboratory Animal Imaging: High Resolution Microcomputed Tomography System
    RAMIRO TORIBIO; Fiscal Year: 2006
    ..Salary and benefits for the Supervisor and Space and utilities for the instrument will be provided by Department of Veterinary Biosciences and the College of Veterinary Medicine. ..
  23. Regulation of Apical Polarity in Breast Cancer
    SOPHIE LELIEVRE; Fiscal Year: 2006
    ..This project should bring a better knowledge of the involvement of apical polarity loss in breast cancer progression and identify novel markers for prognosis-related studies and targets to prevent tumor progression. ..
  24. PTHrP on normal osteoblast differentiation and function
    RAMIRO TORIBIO; Fiscal Year: 2007
    ..Dr. Thomas Rosol's laboratory will provide an excellent environment for developing the skills necessary to become a successful independent researcher. ..
  25. MTA1 IN ONCOGENESIS
    Rakesh Kumar; Fiscal Year: 2009
    ..As molecule studied here and radiotherapy are not cancer specific, lessons learned from the current study will have a significant impact on other cancers with increased MTA1. ..
  26. Identification of Breast Tumor Secretome Changes Throughout Tumor Progression
    Baogang Xu; Fiscal Year: 2007
    ..In conclusion, successful implementation of this innovative technology will accelerate our understanding of basic tumor biology raising the possibility for advances in the clinical treatment of breast tumor. ..
  27. Roles for ING4 as a tumor suppressor in breast cancer
    Suwon Kim; Fiscal Year: 2006
    ....
  28. HER2 Pathway in Breast Cancer Progression and Treatment
    Rakesh Kumar; Fiscal Year: 2007
    ..abstract_text> ..
  29. SERM Regulation of PAK Pathway in Endometrial Cancer
    Rakesh Kumar; Fiscal Year: 2007
    ..abstract_text> ..
  30. Regulation of Cellular Zn Redistribution: A Role of ZnT2
    SHANNON KELLEHER; Fiscal Year: 2009
    ..Thus, this application has significance for improving public health outcomes and advancing our understanding of basic cellular mechanisms. ..
  31. NuMA function in nonmalignant and malignant breast cells
    SOPHIE LELIEVRE; Fiscal Year: 2007
    ..Thus, it is time to emphasize the role of structural nuclear proteins in gene transcription in order to get a complete picture of gene expression control. ..
  32. Pak1 and Hormone Response in Breast Cancer Progression
    Rakesh Kumar; Fiscal Year: 2007
    ..This research is significant in that the knowledge gained from this research will enhance our understanding of the critical regulatory pathways with established roles in breast cancer progression. ..