african americans

Summary

Summary: Persons living in the United States having origins in any of the black groups of Africa.

Top Publications

  1. ncbi Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey
    Earl S Ford
    Centers for Disease Control and Prevention, 1600 Clifton Rd NE, Mailstop E 17, Atlanta, GA 30333
    JAMA 287:356-9. 2002
  2. ncbi The structure of haplotype blocks in the human genome
    Stacey B Gabriel
    Whitehead MIT Center for Genome Research, Cambridge, MA 02139, USA
    Science 296:2225-9. 2002
  3. ncbi Race, breast cancer subtypes, and survival in the Carolina Breast Cancer Study
    Lisa A Carey
    Division of Hematology Oncology, School of Public Health, Department of Epidemiology, University of North Carolina Lineberger Comprehensive Cancer Center, Chapel Hill, NC 27599 7305, USA
    JAMA 295:2492-502. 2006
  4. pmc Sensitive detection of chromosomal segments of distinct ancestry in admixed populations
    Alkes L Price
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    PLoS Genet 5:e1000519. 2009
  5. pmc A genome-wide association study of hypertension and blood pressure in African Americans
    Adebowale Adeyemo
    Center for Research on Genomics and Global Health, National Human Genome Research Institute, NIH, Bethesda, MD, USA
    PLoS Genet 5:e1000564. 2009
  6. pmc The genetic structure and history of Africans and African Americans
    Sarah A Tishkoff
    Department of Biology, University of Maryland, College Park, MD 20742, USA
    Science 324:1035-44. 2009
  7. pmc The contextual effect of the local food environment on residents' diets: the atherosclerosis risk in communities study
    Kimberly Morland
    Department of Epidemiology, University of North Carolina, Chapel Hill, USA
    Am J Public Health 92:1761-7. 2002
  8. pmc Association of trypanolytic ApoL1 variants with kidney disease in African Americans
    Giulio Genovese
    Division of Nephrology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Science 329:841-5. 2010
  9. ncbi Waist circumference percentiles in nationally representative samples of African-American, European-American, and Mexican-American children and adolescents
    Jose R Fernandez
    Section on Statistical Genetics, Department of Biostatistics, Clinical Nutrition Research Center, University of Alabama at Birmingham, 35294 3360, USA
    J Pediatr 145:439-44. 2004
  10. pmc The landscape of recombination in African Americans
    Anjali G Hinch
    Wellcome Trust Centre for Human Genetics, Oxford University, Roosevelt Drive, Oxford OX3 7BN, UK
    Nature 476:170-5. 2011

Detail Information

Publications346 found, 100 shown here

  1. ncbi Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey
    Earl S Ford
    Centers for Disease Control and Prevention, 1600 Clifton Rd NE, Mailstop E 17, Atlanta, GA 30333
    JAMA 287:356-9. 2002
    ..Limited information is available about the prevalence of the metabolic syndrome in the United States, however...
  2. ncbi The structure of haplotype blocks in the human genome
    Stacey B Gabriel
    Whitehead MIT Center for Genome Research, Cambridge, MA 02139, USA
    Science 296:2225-9. 2002
    ..Our results provide a foundation for the construction of a haplotype map of the human genome, facilitating comprehensive genetic association studies of human disease...
  3. ncbi Race, breast cancer subtypes, and survival in the Carolina Breast Cancer Study
    Lisa A Carey
    Division of Hematology Oncology, School of Public Health, Department of Epidemiology, University of North Carolina Lineberger Comprehensive Cancer Center, Chapel Hill, NC 27599 7305, USA
    JAMA 295:2492-502. 2006
    ..Gene expression analysis has identified several breast cancer subtypes, including basal-like, human epidermal growth factor receptor-2 positive/estrogen receptor negative (HER2+/ER-), luminal A, and luminal B...
  4. pmc Sensitive detection of chromosomal segments of distinct ancestry in admixed populations
    Alkes L Price
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    PLoS Genet 5:e1000519. 2009
    ..the method empirically by applying it to populations that have experienced recent and ancient admixture: 935 African Americans from the United States and 29 Mozabites from North Africa...
  5. pmc A genome-wide association study of hypertension and blood pressure in African Americans
    Adebowale Adeyemo
    Center for Research on Genomics and Global Health, National Human Genome Research Institute, NIH, Bethesda, MD, USA
    PLoS Genet 5:e1000564. 2009
    ..genetic variants underlying blood pressure (BP) by conducting a genome-wide association study (GWAS) among African Americans, a population group in the United States that is disproportionately affected by hypertension and associated ..
  6. pmc The genetic structure and history of Africans and African Americans
    Sarah A Tishkoff
    Department of Biology, University of Maryland, College Park, MD 20742, USA
    Science 324:1035-44. 2009
    ..The ancestry of African Americans is predominantly from Niger-Kordofanian (approximately 71%), European (approximately 13%), and other African ..
  7. pmc The contextual effect of the local food environment on residents' diets: the atherosclerosis risk in communities study
    Kimberly Morland
    Department of Epidemiology, University of North Carolina, Chapel Hill, USA
    Am J Public Health 92:1761-7. 2002
    ..We studied the association between the local food environment and residents' report of recommended dietary intake...
  8. pmc Association of trypanolytic ApoL1 variants with kidney disease in African Americans
    Giulio Genovese
    Division of Nephrology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Science 329:841-5. 2010
    b>African Americans have higher rates of kidney disease than European Americans...
  9. ncbi Waist circumference percentiles in nationally representative samples of African-American, European-American, and Mexican-American children and adolescents
    Jose R Fernandez
    Section on Statistical Genetics, Department of Biostatistics, Clinical Nutrition Research Center, University of Alabama at Birmingham, 35294 3360, USA
    J Pediatr 145:439-44. 2004
    ..To describe and provide estimates of the distribution of waist circumference (WC) according to percentiles in African-, European-, and Mexican-American children, and to test for group differences at different percentiles...
  10. pmc The landscape of recombination in African Americans
    Anjali G Hinch
    Wellcome Trust Centre for Human Genetics, Oxford University, Roosevelt Drive, Oxford OX3 7BN, UK
    Nature 476:170-5. 2011
    ..1 million crossovers in 30,000 unrelated African Americans. At intervals of more than three megabases it is nearly identical to a map built in Europeans...
  11. pmc Demographic differences and trends of vitamin D insufficiency in the US population, 1988-2004
    Adit A Ginde
    Department of Emergency Medicine, University of Colorado Denver School of Medicine, Aurora, 80045, USA
    Arch Intern Med 169:626-32. 2009
    ..Vitamin D insufficiency is associated with suboptimal health. The prevalence of vitamin D insufficiency may be rising, but population-based trends are uncertain. We sought to evaluate US population trends in vitamin D insufficiency...
  12. ncbi Tumor immunobiological differences in prostate cancer between African-American and European-American men
    Tiffany A Wallace
    Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892 4258, USA
    Cancer Res 68:927-36. 2008
    ..The profiles portray the existence of a distinct tumor microenvironment in these two patient groups...
  13. ncbi Cancer statistics for African Americans, 2013
    Carol DeSantis
    Surveillance and Health Services Research, American Cancer Society, Atlanta, GA 30303, USA
    CA Cancer J Clin 63:151-66. 2013
    In this article, the American Cancer Society estimates the number of new cancer cases and deaths for African Americans and compiles the most recent data on cancer incidence, mortality, survival, and screening prevalence based upon ..
  14. pmc Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project
    Guillaume Lettre
    Montreal Heart Institute, Montreal, Canada
    PLoS Genet 7:e1001300. 2011
    Coronary heart disease (CHD) is the leading cause of mortality in African Americans. To identify common genetic polymorphisms associated with CHD and its risk factors (LDL- and HDL-cholesterol (LDL-C and HDL-C), hypertension, smoking, ..
  15. ncbi A randomized, placebo-controlled trial of vitamin D supplementation to improve glycaemia in overweight and obese African Americans
    S S Harris
    Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Diabetes Obes Metab 14:789-94. 2012
    Vitamin D deficiency may increase the risk for type 2 diabetes. African Americans tend to have poor vitamin D status and increased risk of diabetes, but effects of vitamin D supplementation on components of diabetes risk have not been ..
  16. ncbi The reasons for geographic and racial differences in stroke study: objectives and design
    Virginia J Howard
    Department of Epidemiology, University of Alabama at Birmingham, USA
    Neuroepidemiology 25:135-43. 2005
    ..Participants are followed via telephone at 6-month intervals for identification of stroke events. The novel aspects of the REGARDS study allow for the creation of a national cohort to address geographic and ethnic differences in stroke...
  17. ncbi State of disparities in cardiovascular health in the United States
    George A Mensah
    Office of the Director, Division of Adult and Community Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control, Mail Stop K 40, 4770 Buford Hwy NE, Atlanta, GA 30341 3717, USA
    Circulation 111:1233-41. 2005
    ..Having timely access to current data on disparities is important for policy and program development. Accordingly, we assessed the current magnitude of disparities in cardiovascular disease (CVD) and its risk factors in the United States...
  18. ncbi Estimation of individual admixture: analytical and study design considerations
    Hua Tang
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Genet Epidemiol 28:289-301. 2005
    ..g., simulations) not possible by Bayesian methods. Our simulation results demonstrate that inclusion of ancestral populations or their surrogates in the analysis is required by any method of IA estimation to obtain reasonable results...
  19. ncbi Skin pigmentation, biogeographical ancestry and admixture mapping
    Mark D Shriver
    Department of Anthropology, Penn State University, 409 Carpenter Bld, University Park, PA 16802, USA
    Hum Genet 112:387-99. 2003
    ..We have genotyped these markers in two population samples with primarily African ancestry, viz. African Americans from Washington D.C...
  20. ncbi Revisiting a neglected construct: parenting styles in a child-feeding context
    Sheryl O Hughes
    Department of Pediatrics, Children s Nutrition Research Center, Baylor College of Medicine, 1100 Bates Avenue, Houston, TX 77030 2600, USA
    Appetite 44:83-92. 2005
    ..Further, differences were found among the feeding styles on an independent measure of child's body mass index...
  21. pmc Variants in the ATP-binding cassette transporter (ABCA7), apolipoprotein E ϵ4,and the risk of late-onset Alzheimer disease in African Americans
    Christiane Reitz
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Gertrude H Sergievsky Center, Columbia University, 630 W 168th St, New York, NY 10032, USA
    JAMA 309:1483-92. 2013
    ..Identification of disease-associated variants helps identify targets for genetic testing, prevention, and treatment...
  22. ncbi Ethnic differences in coronary calcification: the Multi-Ethnic Study of Atherosclerosis (MESA)
    Diane E Bild
    Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, Bethesda, MD, USA
    Circulation 111:1313-20. 2005
    ....
  23. pmc Most common single-nucleotide polymorphisms associated with rheumatoid arthritis in persons of European ancestry confer risk of rheumatoid arthritis in African Americans
    Laura B Hughes
    University of Alabama at Birmingham, 1530 3rd Avenue South, SHEL 210, Birmingham, AL 35294 2182, USA
    Arthritis Rheum 62:3547-53. 2010
    ..The influence of these risk alleles has not been comprehensively studied in African Americans. We therefore sought to examine whether these validated RA risk alleles are associated with RA risk in an ..
  24. ncbi Differences in breast carcinoma characteristics in newly diagnosed African-American and Caucasian patients: a single-institution compilation compared with the National Cancer Institute's Surveillance, Epidemiology, and End Results database
    Gloria J Morris
    Department of Medical Oncology, Kimmel Cancer Center, Thomas Jefferson University Hospital, Philadelphia, PA 19107, USA
    Cancer 110:876-84. 2007
    ..Breast carcinomas in African-American patients appear to be more aggressive than in Caucasian patients due to multifactorial differences...
  25. pmc Fine-mapping classical HLA variation associated with durable host control of HIV-1 infection in African Americans
    Paul J McLaren
    Division of Genetics, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Hum Mol Genet 21:4334-47. 2012
    ..acid positions demonstrates that HLA-B position 97 is the most significant association with host control in African Americans (omnibus P = 1.2 × 10(-21)) and explains the signal of several HLA-B alleles, including B*57:03...
  26. pmc Fine-mapping of breast cancer susceptibility loci characterizes genetic risk in African Americans
    Fang Chen
    Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA
    Hum Mol Genet 20:4491-503. 2011
    ..we identified markers in four regions that better capture the association with breast cancer risk in African Americans as defined by the index signal (2q35, 5q11, 10q26 and 19p13)...
  27. pmc A systematic mapping approach of 16q12.2/FTO and BMI in more than 20,000 African Americans narrows in on the underlying functional variation: results from the Population Architecture using Genomics and Epidemiology (PAGE) study
    Ulrike Peters
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
    PLoS Genet 9:e1003171. 2013
    ..However, follow-up studies in African Americans (AA) have shown no support for some of the most consistently BMI-associated FTO index single nucleotide ..
  28. pmc A genome-wide association search for type 2 diabetes genes in African Americans
    Nicholette D Palmer
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, North Carolina, United States of America
    PLoS ONE 7:e29202. 2012
    b>African Americans are disproportionately affected by type 2 diabetes (T2DM) yet few studies have examined T2DM using genome-wide association approaches in this ethnicity...
  29. pmc Common variation in vitamin D pathway genes predicts circulating 25-hydroxyvitamin D Levels among African Americans
    Lisa B Signorello
    International Epidemiology Institute, Rockville, Maryland, United States of America
    PLoS ONE 6:e28623. 2011
    ..b>African Americans are a group at particularly high risk for vitamin D insufficiency but to date have been virtually absent ..
  30. pmc Incidence of atrial fibrillation in whites and African-Americans: the Atherosclerosis Risk in Communities (ARIC) study
    Alvaro Alonso
    Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, 1300 S 2nd Street, Minneapolis, MN 55454 USA
    Am Heart J 158:111-7. 2009
    To define the incidence and cumulative risk of atrial fibrillation (AF) in a population-based cohort of whites and African Americans.
  31. pmc Genome-wide association study of body height in African Americans: the Women's Health Initiative SNP Health Association Resource (SHARe)
    Cara L Carty
    Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Hum Mol Genet 21:711-20. 2012
    ..Specifically, we identify new loci that may reflect population-specific regulation of height and report several known height loci that are important in determining height in African-descent populations...
  32. pmc Evaluation of the metabochip genotyping array in African Americans and implications for fine mapping of GWAS-identified loci: the PAGE study
    Steven Buyske
    Department of Statistics and Biostatistics, Rutgers University, Piscataway, New Jersey, United States of America
    PLoS ONE 7:e35651. 2012
    ..It has 196,725 SNPs concentrated in 257 genomic regions. We evaluated the Metabochip in 5,863 African Americans; 89% of all SNPs passed rigorous quality control with a call rate of 99.9%...
  33. pmc APOL1 genetic variants in focal segmental glomerulosclerosis and HIV-associated nephropathy
    Jeffrey B Kopp
    Kidney Disease Section, National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health, Bethesda, Maryland, USA
    J Am Soc Nephrol 22:2129-37. 2011
    Trypanolytic variants in APOL1, which encodes apolipoprotein L1, associate with kidney disease in African Americans, but whether APOL1-associated glomerular disease has a distinct clinical phenotype is unknown...
  34. pmc H.U.B city steps: methods and early findings from a community-based participatory research trial to reduce blood pressure among African Americans
    Jamie M Zoellner
    Department of Human Nutrition, Foods and Exercise, Virginia Tech, 1981 Kraft Drive 0913, Blacksburg, VA 24061, USA
    Int J Behav Nutr Phys Act 8:59. 2011
    ..This behavioral study describes the conceptual frameworks, methods, and early findings related to the reach, adoption, implementation, and effectiveness on primary blood pressure outcomes...
  35. pmc Replication of genome-wide association studies (GWAS) loci for fasting plasma glucose in African-Americans
    E Ramos
    Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, 12 South Drive, MSC 5635, Bethesda, MD 20892, USA
    Diabetologia 54:783-8. 2011
    ..Thus, it is important to conduct replication analyses in populations with non-European ancestry to identify shared loci associated with FPG across populations...
  36. pmc A genome-wide association study of serum uric acid in African Americans
    Bashira A Charles
    Center for Research on Genomics and Global Health, National Human Genome Research Institute, Bethesda, MD 20892, USA
    BMC Med Genomics 4:17. 2011
    ....
  37. pmc The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans
    Nancy L Saccone
    Department of Genetics, Washington University, St Louis, Missouri 63110, UA
    Cancer Res 69:6848-56. 2009
    ..The nonsynonymous SNP rs16969968, a known risk variant in populations of European-descent, is also significantly associated with risk in African-Americans. Additional SNPs contribute to risk in distinct ways in these two populations...
  38. pmc Ancestry and pharmacogenomics of relapse in acute lymphoblastic leukemia
    Jun J Yang
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Nat Genet 43:237-41. 2011
    ..after childhood ALL have been reported in many clinical studies, with poorer survival observed among African Americans or those with Hispanic ethnicity when compared with European Americans or Asians...
  39. pmc Genome-wide association of anthropometric traits in African- and African-derived populations
    Sun J Kang
    Department of Biostatistics and Epidemiology, Case Western Reserve University, Cleveland, OH 44106, USA
    Hum Mol Genet 19:2725-38. 2010
    ..Meta-analysis of this data set with additional studies in African-ancestry populations will be helpful to improve power to detect novel associations...
  40. pmc Achieving weight and activity goals among diabetes prevention program lifestyle participants
    Rena R Wing
    Prevention Program Coordinating Center, The Biostatistics Center, George Washington University, 6110 Executive Boulevard, Suite 750, Rockville, MD 20852, USA
    Obes Res 12:1426-34. 2004
    ..This paper examines demographic, psychosocial, and behavioral factors related to achieving weight loss and physical activity goals in the DPP lifestyle participants...
  41. ncbi Descriptive analysis of estrogen receptor (ER)-negative, progesterone receptor (PR)-negative, and HER2-negative invasive breast cancer, the so-called triple-negative phenotype: a population-based study from the California cancer Registry
    Katrina R Bauer
    Public Health Institute California Cancer Registry, Sacramento, California 95815 4402, USA
    Cancer 109:1721-8. 2007
    ..The triple-negative phenotype is important because of its relation to the basal-like subtype of breast cancer...
  42. ncbi A regional food-frequency questionnaire for the US Mississippi Delta
    Katherine L Tucker
    Jean Mayer US Department of Agriculture USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Public Health Nutr 8:87-96. 2005
    ....
  43. ncbi Race and triple negative threats to breast cancer survival: a population-based study in Atlanta, GA
    Mary Jo Lund
    Department of Epidemiology, Rollins School of Public Health, Emory University, 1518 Clifton Road, NE, Atlanta, GA 30322, USA
    Breast Cancer Res Treat 113:357-70. 2009
    ..This study examines association of the ER/PR/HER2 subtypes with race and breast cancer survival...
  44. pmc Racial disparities in cancer survival among randomized clinical trials patients of the Southwest Oncology Group
    Kathy S Albain
    Department of Medicine, Loyola University Chicago Stritch School of Medicine, Maywood, IL, USA
    J Natl Cancer Inst 101:984-92. 2009
    ..Our objective was to determine whether racial disparities in survival exist among patients enrolled in consecutive trials conducted by the Southwest Oncology Group (SWOG)...
  45. ncbi Cultural sensitivity in public health: defined and demystified
    K Resnicow
    Rollins School of Public Health of Emory University, Atlanta, Georgia 30322, USA
    Ethn Dis 9:10-21. 1999
    ..Techniques, borrowed from social marketing and health communication theory, for developing culturally sensitive interventions are described. Research is needed to determine the effectiveness of culturally sensitive programs...
  46. pmc Identification of a systemic lupus erythematosus susceptibility locus at 11p13 between PDHX and CD44 in a multiethnic study
    Christopher J Lessard
    Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    Am J Hum Genet 88:83-91. 2011
    ....
  47. pmc Genetic risk assessment of type 2 diabetes-associated polymorphisms in African Americans
    Jessica N Cooke
    Program in Molecular Medicine and Translational Science, Wake Forest School of Medicine, Winston Salem, North Carolina, USA
    Diabetes Care 35:287-92. 2012
    ..These SNPs have not been extensively investigated for individual and cumulative effects on T2D risk in African Americans.
  48. pmc The socioeconomic gradient of diabetes prevalence, awareness, treatment, and control among African Americans in the Jackson Heart Study
    Mario Sims
    Jackson Heart Study, University of Mississippi Medical Center, Jackson, MS, USA
    Ann Epidemiol 21:892-8. 2011
    Little research has focused on the social patterning of diabetes among African Americans. We examined the relationship between socioeconomic status (SES) and the prevalence, awareness, treatment, and control of diabetes among African ..
  49. pmc Evaluating the dissemination of Body & Soul, an evidence-based fruit and vegetable intake intervention: challenges for dissemination and implementation research
    Marlyn Allicock
    Gillings School of Global Public Health, Department of Nutrition, University of North Carolina at Chapel Hill, NC 27599, USA
    J Nutr Educ Behav 44:530-8. 2012
    ..To evaluate whether the evidence-based Body & Soul program, when disseminated and implemented without researcher or agency involvement and support, would achieve results similar to those of earlier efficacy and effectiveness trials...
  50. ncbi Effect of blood pressure lowering and antihypertensive drug class on progression of hypertensive kidney disease: results from the AASK trial
    Jackson T Wright
    Case Western Reserve University, Department of Medicine, University Hospitals of Cleveland and the Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, OH 44106 5014, USA
    JAMA 288:2421-31. 2002
    ..Hypertension is a leading cause of end-stage renal disease (ESRD) in the United States, with no known treatment to prevent progressive declines leading to ESRD...
  51. ncbi High blood pressure trends in children and adolescents in national surveys, 1963 to 2002
    Rebecca Din-Dzietham
    Morehouse School of Medicine, Social Epidemiology Research Center, 520 Westview Dr SW, NCPC 315, Atlanta, GA 30310 1495, USA
    Circulation 116:1488-96. 2007
    ..In the face of growing obesity, we sought to assess high blood pressure (HBP) secular trends in children and adolescents enrolled in national surveys and to determine whether the HBP trend reversed its course with the rise in obesity...
  52. ncbi Church-based health promotion interventions: evidence and lessons learned
    Marci Kramish Campbell
    UNC Lineberger Comprehensive Cancer Center and the Department of Nutrition, School of Public Health, University of North Carolina, Chapel Hill, NC 27599 7461 USA
    Annu Rev Public Health 28:213-34. 2007
    ..For African Americans, health interventions that incorporate spiritual and cultural contextualization have been effective...
  53. pmc Interaction of FKBP5 with childhood adversity on risk for post-traumatic stress disorder
    Pingxing Xie
    Department of Genetics, Yale University School of Medicine, New Haven, CT, USA
    Neuropsychopharmacology 35:1684-92. 2010
    ..One thousand one hundred forty-three European Americans (EAs) and 1284 African Americans (AAs) recruited for studies of the genetics of substance dependence were also screened for lifetime PTSD...
  54. pmc A meta-analysis and genome-wide association study of platelet count and mean platelet volume in african americans
    Rehan Qayyum
    GeneSTAR Research Program, Division of General Internal Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland, United States of America
    PLoS Genet 8:e1002491. 2012
    ..In this meta-analysis of 7 genome-wide association studies (GWAS) enrolling African Americans, our aim was to identify novel genetic variants associated with platelet count and MPV...
  55. pmc Weight loss and African-American women: a systematic review of the behavioural weight loss intervention literature
    M L Fitzgibbon
    Departments of Medicine, University of Illinois at Chicago, Chicago, IL 60608, USA
    Obes Rev 13:193-213. 2012
    ..This will help enable the adoption of healthier behaviours for this group of women disproportionately affected by obesity...
  56. pmc Intramyocellular lipid and insulin resistance: differential relationships in European and African Americans
    Katherine H Ingram
    Department of Biostatistics, University of Alabama, Birmingham, Alabama, USA
    Obesity (Silver Spring) 19:1469-75. 2011
    ..study the interrelationships among IMCL, insulin sensitivity, and adiposity in European Americans (EAs) and African Americans (AAs)...
  57. ncbi Racial and ethnic differences in cardiovascular disease risk factors: a systematic review
    Anita K Kurian
    School of Public Health, University of North Texas Health Science Center, Plano Tarrant County Public Health, Fort Worth, Texas, USA
    Ethn Dis 17:143-52. 2007
    ....
  58. ncbi Text messaging to motivate walking in older African Americans: a randomized controlled trial
    Bang Hyun Kim
    Office of Minority Health and Health Disparities, Lombardi Comprehensive Cancer Center, Georgetown University, Washington DC 20003, USA
    Am J Prev Med 44:71-5. 2013
    ..Older minority populations can benefit from increased physical activity, especially walking. Text messaging interventions have the potential to encourage positive changes in health behavior in these groups...
  59. pmc Frequency of EGFR and KRAS mutations in lung adenocarcinomas in African Americans
    J Matthew Reinersman
    Memorial Sloan Kettering Cancer Center, New York City, New York 10065, USA
    J Thorac Oncol 6:28-31. 2011
    ..KRAS mutations confer resistance to EGFR-tyrosine kinase inhibitors. The prevalence of these mutations in African American patients has not been thoroughly investigated...
  60. pmc New approaches to disease mapping in admixed populations
    Michael F Seldin
    Department of Biochemistry and Molecular Medicine, University of California Davis, Davis, California, USA
    Nat Rev Genet 12:523-8. 2011
    Admixed populations such as African Americans and Hispanic Americans are often medically underserved and bear a disproportionately high burden of disease...
  61. pmc Differential effects of MYH9 and APOL1 risk variants on FRMD3 Association with Diabetic ESRD in African Americans
    Barry I Freedman
    Section on Nephrology, Department of Internal Medicine, Wake Forest School of Medicine, Winston Salem, North Carolina, USA
    PLoS Genet 7:e1002150. 2011
    ..APOL1 on chromosome 22 (c22) are powerfully associated with non-diabetic end-stage renal disease (ESRD) in African Americans (AAs)...
  62. ncbi Prevalence of obesity among US preschool children in different racial and ethnic groups
    Sarah E Anderson
    Division of Epidemiology, College of Public Health, The Ohio State University, B216 Starling Loving Hall, 320 W 10th Avenue, Columbus, OH 43210, USA
    Arch Pediatr Adolesc Med 163:344-8. 2009
    ..To estimate the prevalence of obesity in 5 major racial/ethnic groups in 4-year-old US children...
  63. pmc The impact of FADS genetic variants on ω6 polyunsaturated fatty acid metabolism in African Americans
    Rasika A Mathias
    Division of General Internal Medicine, Department of Medicine, The GeneSTAR Research Program, The Johns Hopkins University, Baltimore, MD 21224, USA
    BMC Genet 12:50. 2011
    ....
  64. ncbi Prevalence of knee symptoms and radiographic and symptomatic knee osteoarthritis in African Americans and Caucasians: the Johnston County Osteoarthritis Project
    Joanne M Jordan
    Thurston Arthritis Research Center and Department of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599 7280, USA
    J Rheumatol 34:172-80. 2007
    To report contemporary estimates of the prevalence of knee-related osteoarthritis (OA) outcomes in African Americans and Caucasians aged > or = 45 years.
  65. ncbi Race-ethnicity-specific waist circumference cutoffs for identifying cardiovascular disease risk factors
    Shankuan Zhu
    Injury Research Center and Department of Family and Community Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Am J Clin Nutr 81:409-15. 2005
    ..However, WC cutoffs for other race-ethnicity groups remain unknown...
  66. ncbi Preterm low birth weight and periodontal disease among African Americans
    Ananda P Dasanayake
    Department of Epidemiology and Health Promotion, New York University College of Dentistry, 345 East 24th Street, New York, NY 10010, USA
    Dent Clin North Am 47:115-25, x-xi. 2003
    b>African Americans consistently experience higher rates of preterm and low birth weight (LBW) deliveries than do whites...
  67. pmc Evaluation of 11 breast cancer susceptibility loci in African-American women
    Wei Zheng
    Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt Ingram Cancer Center, Nashville, TN 37203 1738, USA
    Cancer Epidemiol Biomarkers Prev 18:2761-4. 2009
    ..The results from this study extend some of the recent GWAS findings to African-Americans and may guide future efforts to identify the causal variants for breast cancer...
  68. pmc Leukocyte telomeres are longer in African Americans than in whites: the National Heart, Lung, and Blood Institute Family Heart Study and the Bogalusa Heart Study
    Steven C Hunt
    Cardiovascular Genetics Division, University of Utah School of Medicine, Salt Lake City, UT, USA NHLBI Family Heart Study
    Aging Cell 7:451-8. 2008
    Leukocyte telomere length (LTL) is ostensibly a bio-indicator of human aging. Here we report that African Americans have longer LTL than whites...
  69. pmc Association of glycemic index and glycemic load with risk of incident coronary heart disease among Whites and African Americans with and without type 2 diabetes: the Atherosclerosis Risk in Communities study
    Dale S Hardy
    Division of Epidemiology, University of Texas School of Public Health, Houston, TX 77225, USA
    Ann Epidemiol 20:610-6. 2010
    In this study we examined whether high glycemic index (GI) and glycemic load (GL) diets are associated with increased risk of developing coronary heart disease (CHD) in Whites and African Americans with and without type 2 diabetes.
  70. pmc Accuracy of genome-wide imputation of untyped markers and impacts on statistical power for association studies
    Ke Hao
    Genetics Department, Rosetta Inpharmatics, a Wholly Owned Subsidiary of Merck and Co Inc, Seattle, Washington, USA
    BMC Genet 10:27. 2009
    ..Genome-wide imputation of untyped markers allows us to address these issues in a direct fashion...
  71. ncbi Sociocultural correlates of menthol cigarette smoking among adult African Americans in Los Angeles
    Bruce Allen
    Charles R Drew University of Medicine and Science, Los Angeles, CA 90059, USA
    Nicotine Tob Res 9:447-51. 2007
    ..Results indicate that menthol smoking among adult African Americans is at least partly a consequence of a complex set of social and cultural norms...
  72. pmc Greater risk for HIV infection of black men who have sex with men: a critical literature review
    Gregorio A Millett
    Centers for Disease Control and Prevention, 1600 Clifton Rd, Mail Stop E 45, Atlanta, GA 30333, USA
    Am J Public Health 96:1007-19. 2006
    ..Evidence was insufficient to evaluate the remaining hypotheses.Future studies must address these hypotheses to provide additional explanations for the greater prevalence of HIV infection among Black MSM...
  73. ncbi Weight loss of black, white, and Hispanic men and women in the Diabetes Prevention Program
    Delia S West
    Department of Health Behavior and Health Education, University of Arkansas for Medical Sciences, Fay W Boozman College of Public Health, Little Rock, Arkansas, USA
    Obesity (Silver Spring) 16:1413-20. 2008
    ....
  74. ncbi Race and gender differences in C-reactive protein levels
    Amit Khera
    Donald W Reynolds Cardiovascular Clinical Research Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9047, USA
    J Am Coll Cardiol 46:464-9. 2005
    ..This study sought to determine whether there are race and gender differences in the distribution of C-reactive protein (CRP) levels...
  75. pmc Triple-negative breast cancers are increased in black women regardless of age or body mass index
    Lesley A Stead
    Department of Medicine, Boston University Medical Center, Boston, MA 02118, USA
    Breast Cancer Res 11:R18. 2009
    ..We focused on triple-negative (Tneg) tumours (oestrogen receptor (ER), progesterone receptor (PR) and HER2 negative), which are associated with poor prognosis...
  76. pmc Risk factors for end-stage renal disease: 25-year follow-up
    Chi yuan Hsu
    Department of Medicine, University of California, San Francisco, 521 Parnassus Avenue, San Francisco, CA 94143 0532, USA
    Arch Intern Med 169:342-50. 2009
    ..Few cohort studies have focused on risk factors for end-stage renal disease (ESRD). This investigation evaluated the prognostic value of several potential novel risk factors for ESRD after considering established risk factors...
  77. pmc FTO genetic variation and association with obesity in West Africans and African Americans
    Adebowale Adeyemo
    Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA
    Diabetes 59:1549-54. 2010
    ..However, data from populations of African ancestry are limited. We evaluated genetic variation in the FTO gene and investigated associations with obesity in West Africans and African Americans.
  78. ncbi Causes and prevalence of visual impairment among adults in the United States
    Nathan Congdon
    Wilmer Eye Institute, Wilmer 120, 600 N Wolfe Street, Baltimore, MD 21287, USA
    Arch Ophthalmol 122:477-85. 2004
    ..To estimate the cause-specific prevalence and distribution of blindness and low vision in the United States by age, race/ethnicity, and gender, and to estimate the change in these prevalence figures over the next 20 years...
  79. ncbi Are HIV/AIDS conspiracy beliefs a barrier to HIV prevention among African Americans?
    Laura M Bogart
    Health Program, RAND Corporation, Santa Monica, CA 90407 2138, USA
    J Acquir Immune Defic Syndr 38:213-8. 2005
    This study examined endorsement of HIV/AIDS conspiracy beliefs and their relations to consistent condom use and condom attitudes among African Americans.
  80. pmc Genotype imputation of Metabochip SNPs using a study-specific reference panel of ~4,000 haplotypes in African Americans from the Women's Health Initiative
    Eric Yi Liu
    Department of Computer Science, University of North Carolina, Chapel Hill, NC 27599, USA
    Genet Epidemiol 36:107-17. 2012
    ..In this work, we constructed a study-specific reference panel of 3,924 haplotypes using African Americans in the Women's Health Initiative (WHI) genotyped on both the Metabochip and the Affymetrix 6.0 GWAS platform...
  81. ncbi Body and soul. A dietary intervention conducted through African-American churches
    Ken Resnicow
    School of Public Health, University of Michigan, Ann Arbor, Michigan, USA
    Am J Prev Med 27:97-105. 2004
    ..a national voluntary agency (American Cancer Society), and the National Institutes of Health to disseminate and evaluate under real-world conditions the impact of previously developed dietary interventions for African Americans.
  82. ncbi Socioeconomic disparities in metabolic syndrome differ by gender: evidence from NHANES III
    Eric B Loucks
    Department of Psychiatry and Douglas Hospital Research Centre, McGill University, Montreal, Quebec, Canada
    Ann Epidemiol 17:19-26. 2007
    ..The aim of the study is to examine whether socioeconomic position (SEP) is associated with metabolic syndrome and whether the association differs by gender and race/ethnicity...
  83. ncbi Racial and ethnic differences in secular trends for childhood BMI, weight, and height
    David S Freedman
    Division of Nutrition and Physical Activity, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Obesity (Silver Spring) 14:301-8. 2006
    ..The prevalence of childhood overweight in the United States has markedly increased over the last 30 years. We examined differences in the secular trends for BMI, weight, and height among white, black, and Mexican-American children...
  84. pmc Host determinants of HIV-1 control in African Americans
    Kimberly Pelak
    Center for Human Genome Variation, Duke University Medical School, Durham, North Carolina, USA
    J Infect Dis 201:1141-9. 2010
    ..a whole-genome association study of human immunodeficiency virus type 1 (HIV-1) set point among a cohort of African Americans (n = 515), and an intronic single-nucleotide polymorphism (SNP) in the HLA-B gene showed one of the ..
  85. ncbi Ancestry informative marker panels for African Americans based on subsets of commercially available SNP arrays
    Arti Tandon
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genet Epidemiol 35:80-3. 2011
    Admixture mapping is a widely used method for localizing disease genes in African Americans. Most current methods for inferring ancestry at each locus in the genome use a few thousand single nucleotide polymorphisms (SNPs) that are very ..
  86. pmc MYH9 is associated with nondiabetic end-stage renal disease in African Americans
    W H Linda Kao
    Department of Epidemiology, School of Medicine and Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21287, USA
    Nat Genet 40:1185-92. 2008
    As end-stage renal disease (ESRD) has a four times higher incidence in African Americans compared to European Americans, we hypothesized that susceptibility alleles for ESRD have a higher frequency in the West African than the European ..
  87. pmc Interactive effect of stressful life events and the serotonin transporter 5-HTTLPR genotype on posttraumatic stress disorder diagnosis in 2 independent populations
    Pingxing Xie
    Department of Genetics, Yale University School of Medicine, New Haven, CT, USA
    Arch Gen Psychiatry 66:1201-9. 2009
    ..Previous studies generally focused on its effect on depressive symptoms; little is known about its moderation of the development of posttraumatic stress disorder (PTSD)...
  88. pmc Polymorphic allele of human IRGM1 is associated with susceptibility to tuberculosis in African Americans
    Katherine Y King
    Department of Pediatrics, Section of Infectious Diseases, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS ONE 6:e16317. 2011
    ..Among African Americans, the TB cases were more likely to carry the CD-related T allele of rs10065172 (odds ratio of 1...
  89. pmc Large-scale candidate gene analysis in whites and African Americans identifies IL6R polymorphism in relation to atrial fibrillation: the National Heart, Lung, and Blood Institute's Candidate Gene Association Resource (CARe) project
    Renate B Schnabel
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    Circ Cardiovasc Genet 4:557-64. 2011
    The genetic background of atrial fibrillation (AF) in whites and African Americans is largely unknown. Genes in cardiovascular pathways have not been systematically investigated.
  90. pmc Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study
    Ervin R Fox
    Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA
    Hum Mol Genet 20:2273-84. 2011
    The prevalence of hypertension in African Americans (AAs) is higher than in other US groups; yet, few have performed genome-wide association studies (GWASs) in AA...
  91. pmc Differences in arachidonic acid levels and fatty acid desaturase (FADS) gene variants in African Americans and European Americans with diabetes or the metabolic syndrome
    Susan Sergeant
    The Center for Botanical Lipids and Inflammatory Disease Prevention, Wake Forest School of Medicine, Winston Salem, NC 27157, USA
    Br J Nutr 107:547-55. 2012
    ..Compared with European Americans (EAm), African Americans (AfAm) exhibited markedly higher serum levels of arachidonic acid (AA) (EAm 7·9 (sd 2·1), AfAm 9·8 (sd 1·..
  92. pmc A comprehensive genetic association study of Alzheimer disease in African Americans
    Mark W Logue
    Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    Arch Neurol 68:1569-79. 2011
    To evaluate the association of genetic variation with late-onset Alzheimer disease (AD) in African Americans, including genes implicated in recent genome-wide association studies of whites.
  93. pmc Candidate gene association resource (CARe): design, methods, and proof of concept
    Kiran Musunuru
    Broad Institute, Cambridge, MA 02142, USA
    Circ Cardiovasc Genet 3:267-75. 2010
    ..The goals of CARe include the discovery of new variants associated with traits using a candidate gene approach and the discovery of new variants using the genome-wide association mapping approach specifically in African Americans.
  94. pmc Genetic ancestry in lung-function predictions
    Rajesh Kumar
    Division of Allergy and Immunology, Children s Memorial Hospital, 2300 Children s Plaza, Box 60, Chicago IL 60614, USA
    N Engl J Med 363:321-30. 2010
    ....
  95. ncbi Social resources and cognitive decline in a population of older African Americans and whites
    L L Barnes
    Rush Alzheimer s Disease Center, Rush University Medical Center, Armour Academic Facility, 600 S Paulina, Suite 1038, Chicago, IL 60612, USA
    Neurology 63:2322-6. 2004
    ..To examine the relation of social resources and cognitive decline in older adults...
  96. ncbi Vitamin D deficiency in systemic lupus erythematosus
    Diane L Kamen
    Medical University of South Carolina, Charleston, SC, USA
    Autoimmun Rev 5:114-7. 2006
    ..Overall, 67% of the subjects were vitamin D deficient, with mean levels significantly lower among African Americans (15.9 ng/ml) compared to Caucasians (31.3 ng/ml)...
  97. pmc Characterizing the admixed African ancestry of African Americans
    Fouad Zakharia
    Department of Genetics, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA
    Genome Biol 10:R141. 2009
    ..applied recently developed statistical and computational techniques to the question of African ancestry in African Americans by using data on more than 450,000 single-nucleotide polymorphisms (SNPs) genotyped in 94 Africans of ..
  98. pmc Nicotinic acetylcholine receptor region on chromosome 15q25 and lung cancer risk among African Americans: a case-control study
    Christopher I Amos
    Department of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    J Natl Cancer Inst 102:1199-205. 2010
    ..Thus, among African American persons, multiple loci in the region of chromosome 15q25.1 appear to be strongly associated with lung cancer risk...
  99. pmc Nucleotide excision repair genes and risk of lung cancer among San Francisco Bay Area Latinos and African Americans
    Jeffrey S Chang
    Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA
    Int J Cancer 123:2095-104. 2008
    ..association between nucleotide excision repair (NER) variants and lung cancer risk have included Latinos and African Americans. We examine variants in 6 NER genes (ERCC2, ERCC4, ERCC5, LIG1, RAD23B and XPC) in association with primary ..
  100. ncbi Physical activity social support and middle- and older-aged minority women: results from a US survey
    A A Eyler
    Prevention Research Center, Saint Louis University School of Public Health, MO 63376, USA
    Soc Sci Med 49:781-9. 1999
    ..Research on the determinants of physical activity have indicated that social support is one of the strongest correlates, but little is known about this relation in important subgroups of middle and older-aged women...
  101. ncbi A randomized controlled trial of weight reduction and exercise for diabetes management in older African-American subjects
    T D Agurs-Collins
    Division of Epidemiology and Cancer Control, Howard University Cancer Center, Washington, DC 20006, USA
    Diabetes Care 20:1503-11. 1997
    ..To evaluate a weight loss and exercise program designed to improve diabetes management in older African-Americans...

Research Grants77

  1. Genome-wide recombination as a risk factor for nondisjunction
    NATASHA D HOLLIS; Fiscal Year: 2010
    ..The reference letters are strong. She has the necessary package to excel as a pre-doctoral fellow. ..
  2. Prostate, Lung, Colorectal and Ovarian (PLCO) Screening Trial
    Mona Fouad; Fiscal Year: 2013
    ..One site in Detroit, MI focused efforts on increasing the participation of African Americans. A site in Denver, CO hired Spanish speaking staff to enhance the number of Hispanic Americans enrolled in ..
  3. Prostate, Lung, Colorectal and Ovarian (PLCO) Screening Trial
    BARBARA O'BRIEN; Fiscal Year: 2013
    ..One site in Detroit, MI focused efforts on increasing the participation of African Americans. A site in Denver, CO hired Spanish speaking staff to enhance the number of Hispanic Americans enrolled in ..
  4. The role of Fli1 in T cell function and the pathogenesis of lupus
    Tamara K Nowling; Fiscal Year: 2011
    ..Lupus predominantly afflicts women and African Americans/Hispanics...
  5. A MicroRNA Approach to Screen for Sporadic Colon Cancer Exfoliately in Human Stoo
    Farid E Ahmed; Fiscal Year: 2010
    ..Since 1990, the mortality in African Americans has decreased from about 30 to 25 per 100,000 populations, with higher mortality in men than women, and ..
  6. Parathyroid Hormone & Vitamin D Effects on Salt Sensitivity and Vascular Function
    ANNA LIZA BELEN VALINA TOTH; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Vitamin D deficiency is much more common in African Americans than whites...
  7. Pathogenesis of the Metabolic Syndrome
    W Timothy Garvey; Fiscal Year: 2013
    ..The first clue was that IMCL was completely independent of insulin sensitivity in African Americans, while oxidative stress related to lipid peroxidation in muscle was predictive of insulin resistance in both ..
  8. Mechanisms of Endothelin 1-Induced Sickle Cell Pathology
    Alicia Rivera; Fiscal Year: 2011
    ..We plan to characterize mechanisms of ET-1-stimulated sickle red cell dehydration as a means to develop ET-1 receptor antagonists as a novel therapy in the treatment of sickle cell disease. ..
  9. Effects of Standardized Aerobic Exercise-Training on Neurocognitive and Neurodege
    Thomas O Obisesan; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): The primary purpose of this pilot study is to determine whether African Americans (AA) with mild AD (AD) can be enrolled and retained in a 6-month aerobic exercise-training study...
  10. JACKSON HEART STUDY
    ASOKA S SRINIVASAN; Fiscal Year: 2011
    ..abstract_text> ..
  11. JACKSON HEART STUDY
    Herman Taylor; Fiscal Year: 2010
    ..abstract_text> ..
  12. JACKSON HEART STUDY
    HERMAN ALFRED TAYLOR; Fiscal Year: 2009
    ..abstract_text> ..
  13. JACKSON HEART STUDY
    ASOKA S SRINIVASAN; Fiscal Year: 2013
    ..abstract_text> ..
  14. JACKSON HEART STUDY
    Asoka Srinivasan; Fiscal Year: 2010
    ..abstract_text> ..
  15. JACKSON HEART STUDY
    HERMAN ALFRED TAYLOR; Fiscal Year: 2009
    ..abstract_text> ..
  16. Metabolic impact of fructose restriction in obese children
    Jean Marc Schwarz; Fiscal Year: 2013
    ..to TG by DNL, which leads to an increase in liver fat content, VLDL-TG output, and TG levels;but in African Americans, a greater proportion of fructose is converted to glucose, which leads to increased glycemia and insulin ..
  17. K-Mg-citrate as a BP lowering agent in African Americans; role of natriuresis
    ROBERT FRANKLIN REILLY; Fiscal Year: 2010
    ..Multiple studies show that the prevalence of hypertension is increased in African Americans. Racial differences are even more pronounced for severe forms of hypertension, and severe consequences of ..
  18. Hiv-1 Infection: Central Serotonergic Activity and its Health Implications
    Adarsh M Kumar; Fiscal Year: 2010
    ..HIV-1+ cases, N=25;HIV-1- cases N=15), age 25-55 years, belonging to the three ethnic groups (Caucasian, African Americans, Hispanics), who consented during life to participate in the NNTC project...
  19. A Prospective Study of Adiposity and Subclinical Coronary Artery Disease
    CHRISTINA LYNN WASSEL; Fiscal Year: 2010
    ..The RBS includes participants from 3 ethnic groups (Caucasians, African Americans and Filipinos) who had electron beam computed tomography (EBCT) scans of the chest and abdomen for coronary ..
  20. Molecular Mechanism of Acrolein-Induced Vascular Toxicity: Role of PPAR gamma and
    Zivar Yousefipour; Fiscal Year: 2013
    ....
  21. The influence of selenium on biomarkers of prostate cancer risk
    KARAM E EL-BAYOUMY; Fiscal Year: 2012
    ..cancer (PC) is the second leading cause of cancer-related death in men;aging is a major risk factor and African Americans (AA) are at a higher risk than white Americans (WA)...
  22. Diet and Gastrointestinal Cancer Risk in African Americans and Rural Africans
    STEPHEN JD O'KEEFE; Fiscal Year: 2012
    ..We are concerned that the reason why African Americans (AAs) have the highest incidence (c1:70,000 of the population) and death rate from colon cancer in the USA ..
  23. Modulation of cancer prevention by social stress
    Hildegard M Schuller; Fiscal Year: 2010
    ..Low socioeconomic status, which creates chronic psychological stress and is particularly prevalent in African Americans, is associated with a significantly higher incidence and mortality of all cancers...
  24. Biochemical, Biomechanical & Morphological Properties of Quantitative Ultrasound
    Barbara L McFarlin; Fiscal Year: 2010
    ..prematurity is the second leading cause of infant mortality and the leading cause of infant mortality for African Americans. If birth could be delayed from 30 to 34 weeks gestation, the incidence of: inhospital mortality could be ..
  25. A novel allele influencing HIV infection among injection drug users
    Xiao Fang Yu; Fiscal Year: 2012
    ..by established researchers who have had extensive experience in similar types of studies in Caucasians and African Americans is a further advantage...
  26. CNS Demyelinating Autoimmunity Targeting Water Channel Complexes
    SEAN JOSEPH PITTOCK; Fiscal Year: 2013
    ..e., blind or paraparetic) from presumed MS, particularly African Americans, carry a misdiagnosis and will prove to be NMO/AQP4-IgG seropositive...
  27. Mediators of Atherosclerosis in South Asians Living in America
    Alka M Kanaya; Fiscal Year: 2013
    ..S. ethnic groups (Whites, African Americans, Latinos, and Chinese Americans)...
  28. A dataset for the study of the social determinants of health.
    Peter A Muennig; Fiscal Year: 2010
    ..e., African Americans may be more likely than whites to see the question, "People treat me fairly," as having a racial component), ..
  29. Inflammation and Sub-Clinical Renal Damage in Cocaine-Dependent African Americans
    ELIZABETH GROOMS NESMITH; Fiscal Year: 2010
    ..The overall goal of this project is to examine the effects of cocaine dependency on renal physiology in African Americans (AAs)...
  30. Endogenous Cardiac Glycosides in AASK
    Brad C Astor; Fiscal Year: 2010
    ..b>African Americans are disproportionately afflicted with hypertension and CKD, and may be at higher risk of CVD associated with ..
  31. Nikkomycin Z treatment of early coccidioidal pneumonia: Phase II clinical trial
    DAVID LARWOOD; Fiscal Year: 2010
    ..Valley Fever cure would be particularly valuable to groups disproportionately affected by infection such as African Americans, Filipinos, Native American peoples, persons with AIDS or other immunosuppressing conditions, the military, ..
  32. Ethnic/Racial Variation in Intracerebral Hemorrhage (ERICH)
    Daniel Woo; Fiscal Year: 2013
    ..Yet we know little about the biologic differences that lead to this ethnic disparity. Our proposal will compare minorities with ICH to controls from the same population as well as explore genetic, radiographic and outcomes differences. ..
  33. Forward Genetics to Identify Complex Gene Interactions Involved in Glaucoma
    Elena V Semina; Fiscal Year: 2010
    ..Finally, identified genes will be used to address whether othologous loci are affected in human glaucomas. ..
  34. Translational Approaches to Reducing Health Disparities in Lung Disease
    Joe G N Garcia; Fiscal Year: 2012
    ..For instance, disproportionately higher number of African Americans and Hispanics are likely to be exposed to air pollutants compared to Caucasians that is one of the major ..
  35. Characterizing Mitochondrial DNA Susceptibility to Breast, Colorectal, and Prosta
    Iona Cheng; Fiscal Year: 2012
    ..We propose in Aim 1 to characterize the genetic diversity of the mitochondrial genome among African Americans, Japanese Americans, Native Hawaiians, Latinos and Whites...
  36. Conservative Versus Dialytic Management in Stage V Chronic Kidney Disease
    GLENN MATTHEW CHERTOW; Fiscal Year: 2010
    ..Arguably, since ESRD disproportionately affects minority populations, particularly African Americans, the poor and the uninsured, this type of comparative effectiveness research can influence many of the most ..
  37. Surgical Indirect Revascularization For Symptomatic Intracranial Aterial Stenosis
    Nestor Gonzalez; Fiscal Year: 2013
    ....
  38. Interactive Multimedia Intervention to Improve Colonoscopy and Bowel Prep Adhere
    JOHN MATTHEW INADOMI; Fiscal Year: 2012
    ..Adherence to colonoscopy is low among African Americans;moreover, adherence to the colonoscopy preparation is especially low in this population, which contributes ..
  39. Epidemiology of Putative Causal Variants in the Multiethnic Cohort
    Loic Le Marchand; Fiscal Year: 2012
    ..of older adults (45-75 yrs at baseline) for five US racial/ethnic groups (Japanese Americans, African Americans, European Americans, Latinos and Native Hawaiians) at varying risks of chronic diseases...
  40. CARDIA Echocardiography Reading Center
    Joao A C Lima; Fiscal Year: 2012
    ..abstract_text> ..
  41. Effects of Vitamin D and Marine Omega-3 Fatty Acids on Anemia in the Elderly
    Nancy Berliner; Fiscal Year: 2013
    ..abstract_text> ..
  42. NADPH-Oxidase and SLE Susceptibility
    Swapan K Nath; Fiscal Year: 2013
    ..Ultimately, a set of novel functional variants will be made available to the scientific community and provide a basis for future biological experiments to define how NADPHO contributes to the pathological mechanisms of lupus. ..
  43. CARDIA ECHO RC
    Joao A C Lima; Fiscal Year: 2011
    ..abstract_text> ..
  44. Coronary Artery Risk Development in Young Adults (CARDIA) Study - CC
    James Shikany; Fiscal Year: 2012
    ..abstract_text> ..
  45. CARDIA ECHO RC CAN 9-8470189
    Joao Lima; Fiscal Year: 2009
    ..abstract_text> ..
  46. CARDIA ECHO RC
    Joao Lima; Fiscal Year: 2010
    ..abstract_text> ..
  47. FAMU RCMI Pharmaceutical Research Center
    Karam F A Soliman; Fiscal Year: 2013
    ..These efforts will result in positive health outcomes in addition to decreasing and eliminating health disparities. ..
  48. CARDIA
    Sharina D Person; Fiscal Year: 2010
    ..abstract_text> ..
  49. CARDIA
    O Dale Williams; Fiscal Year: 2011
    ..abstract_text> ..
  50. Violence Exposure, Immune Function &HIV/AIDS Risks in African American Young Ad
    FROUGH SAADATMAND; Fiscal Year: 2013
    ..Sanders-Phillips, Kathy Significant disparities exist in rates of HIV/AIDS in the United States and African Americans have the highest infection rates in the country...
  51. Financial Risks and Ethnic/Racial Disparities in Live Kidney Donation
    TANJALA PURNELL; Fiscal Year: 2011
    ..renal disease target focus of improving rates of kidney transplantation and donation, particularly by African Americans and other ethnic/racial minority groups. In her didactic program, Ms...
  52. Polymorphism and mutation spectrum in minorities with non-small cell lung cancer
    David P Carbone; Fiscal Year: 2010
    ..The results should provide tremendous insight into the genomic factors which influence susceptibility, pathogenesis, drug sensitivity, and survival in African-Americans with non-small cell lung cancer. ..
  53. Accelerated Biologic Aging and Risk for Sepsis and Organ Failure Following Trauma
    ELIZABETH GROOMS NESMITH; Fiscal Year: 2012
    ..Research has shown that African Americans (AAs) and persons of low socioeconomic status (SES) have nearly twice the rates of sepsis and organ ..
  54. Impact of adipokines and insulin resistance on progression of prehypertension
    Cynthia Cheng; Fiscal Year: 2013
    ..Early patient intervention will minimize cardiovascular risk by averting the development of irreversible vascular/endothelial damage and clinical HTN. ..
  55. Genetic contributors to diabetes and dyslipidemia in African Americans
    Michele M Sale; Fiscal Year: 2010
    DESCRIPTION (provided by principal investigator): It is estimated that 3.2 million African Americans aged 20 years or older have T2DM...
  56. The Effects of C-Reactive Protein on Autoimmunity
    Terry W Du Clos; Fiscal Year: 2013
    ..Therefore, understanding the role this protein plays in the risk for SLE will aid in understanding the cause and treatment of this and other autoimmune diseases in Veterans. ..
  57. RCT of Stress Reduction in the Secondary Prevention of CHD in African Americans
    Robert Schneider; Fiscal Year: 2010
    ..The mortality rate from cardiovascular disease is twice as high in African Americans as white Americans...
  58. Ubiquitous Mobile Multimedia for Environmental Public Health Outreach and Social
    CESAR BANDERA; Fiscal Year: 2010
    ..65% of white adults in the United States searched online for health information in 2008 versus 51% of African Americans and 44% of Hispanics. An alternate mechanism with which to convey visual content (e.g...
  59. Reasons for Racial Disparities in Venous Thromboembolism
    NEIL ADRIAN ZAKAI; Fiscal Year: 2010
    ..Though understanding the reasons for this disparity we can begin to formulate public health policies to address this disparity. ..
  60. HCV TREATMENT IN AFRICAN AMERICANS VS NON HISPANIC WHIT*
    Lennox Jeffers; Fiscal Year: 2005
    ..sustained virologic response to a 48-week course of Peginterferon alfa-2a in combination with ribavirin in African Americans as compared to non-Hispanic whites with chronic HCV genotype 1 as assessed at the end of 48-week post-..
  61. Arterial Baroreflex Function in African Americans at Rest and During Exercise
    David Keller; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): African Americans are at higher risk than their Caucasian American counterparts for the development of hypertension with hypertension affecting over 40% of the African American adult population...
  62. Does Enhanced School-Readiness Affect Adult Health of African Americans?
    Frances A Campbell; Fiscal Year: 2010
    ..NIH Challenge Grants in Health and Science Research Does Enhanced School-Readiness Affect Adult Health of African Americans? This application addresses Broad Challenge Area (05) Comparative Effectiveness Research, 05-MD-101, Social ..
  63. VIRAHEP-C Clinical Center
    Anna Lok; Fiscal Year: 2005
    ..7 million Americans have evidence of chronic infection. The prevalence of antibody to HCV is higher among African Americans (3.2%) than among the non-Hispanic whites (1.8%)...
  64. Intensive Outpatient v. Outpatient Treatment with Buprenorphine among African Ame
    Shannon Gwin Mitchell; Fiscal Year: 2010
    ..Populations Background: Although there is relatively little difference in illicit drug use rates between African Americans and Whites, there is are significant differences in terms of the collateral impact of opiate use on these ..
  65. Disparities in CHD in the Jackson Heart Study
    Mario Sims; Fiscal Year: 2010
    ..key psychosocial factors (discrimination, stress, and social support) impact coronary heart disease (CHD) in African Americans in Mississippi...
  66. Resistance to Antiviral Therapy in Chronic Hepatitis C
    Norah Terrault; Fiscal Year: 2005
    ..virological response (viral clearance) to pegylated interferon plus ribavirin will be compared in 200 African Americans and 200 non-Hispanic whites...
  67. Application and Dissemination of a Culture-Centered Approach to Tailoring Compara
    Mohan Jyoti Dutta; Fiscal Year: 2010
    ..The proposed project specifically seeks to develop tailored CERSGs on heart disease targeted toward African Americans in Indiana, given the existing disparities among racial/ethnic groups in the area of heart disease, and the ..
  68. A web-based tailored health behavior intervention for African American colon canc
    Marlyn Allicock; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Background African Americans experience disproportionate morbidity and mortality from colon and rectal cancers...
  69. Racial Differences in IFN Transcriptional Response
    Daryl Lau; Fiscal Year: 2009
    ..Approximately 2.4 million Americans have chronic hepatitis C infection and the rate is higher among the African Americans (3.2%) than among the Caucasian population (1.5%)...
  70. Accelerated Repair of Vascular Injury in Diabetes by TGF-beta Modified Stem Cells
    STEPHEN BARTELMEZ; Fiscal Year: 2009
    ..Our focus is to demonstrate proof of principle that adult HSC can be effectively used to repair infarcted coronary vessels and eventually greatly improve the quality and duration of these patient's lives. ..
  71. Cost Effectiveness of a Home Support Program for Depression in Black Elders
    Laura N Gitlin; Fiscal Year: 2010
    ..of our currently funded randomized controlled trial (NIMH R01MH079814) "Treating Depression in Older African Americans") that tests a novel 10- session home-based intervention to treat depression in older community-dwelling ..
  72. HIV EPIDEMIOLOGY AMONG RURAL AFRICAN-AMERICANS
    Adaora Adimora; Fiscal Year: 1999
    HIV infection has emerged as a major public health problem among African Americans in rural regions of the Southeastern United States, where the epidemics of gonorrhea, syphilis, and other curable STDs have also escalated...