african americans

Summary

Summary: Persons living in the United States having origins in any of the black groups of Africa.

Top Publications

  1. ncbi Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey
    Earl S Ford
    Centers for Disease Control and Prevention, 1600 Clifton Rd NE, Mailstop E 17, Atlanta, GA 30333
    JAMA 287:356-9. 2002
  2. ncbi The structure of haplotype blocks in the human genome
    Stacey B Gabriel
    Whitehead MIT Center for Genome Research, Cambridge, MA 02139, USA
    Science 296:2225-9. 2002
  3. ncbi Race, breast cancer subtypes, and survival in the Carolina Breast Cancer Study
    Lisa A Carey
    Division of Hematology Oncology, School of Public Health, Department of Epidemiology, University of North Carolina Lineberger Comprehensive Cancer Center, Chapel Hill, NC 27599 7305, USA
    JAMA 295:2492-502. 2006
  4. pmc Sensitive detection of chromosomal segments of distinct ancestry in admixed populations
    Alkes L Price
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    PLoS Genet 5:e1000519. 2009
  5. pmc A genome-wide association study of hypertension and blood pressure in African Americans
    Adebowale Adeyemo
    Center for Research on Genomics and Global Health, National Human Genome Research Institute, NIH, Bethesda, MD, USA
    PLoS Genet 5:e1000564. 2009
  6. pmc The genetic structure and history of Africans and African Americans
    Sarah A Tishkoff
    Department of Biology, University of Maryland, College Park, MD 20742, USA
    Science 324:1035-44. 2009
  7. pmc Association of trypanolytic ApoL1 variants with kidney disease in African Americans
    Giulio Genovese
    Division of Nephrology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Science 329:841-5. 2010
  8. pmc The contextual effect of the local food environment on residents' diets: the atherosclerosis risk in communities study
    Kimberly Morland
    Department of Epidemiology, University of North Carolina, Chapel Hill, USA
    Am J Public Health 92:1761-7. 2002
  9. pmc Demographic differences and trends of vitamin D insufficiency in the US population, 1988-2004
    Adit A Ginde
    Department of Emergency Medicine, University of Colorado Denver School of Medicine, Aurora, 80045, USA
    Arch Intern Med 169:626-32. 2009
  10. pmc Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project
    Guillaume Lettre
    Montreal Heart Institute, Montreal, Canada
    PLoS Genet 7:e1001300. 2011

Detail Information

Publications307 found, 100 shown here

  1. ncbi Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey
    Earl S Ford
    Centers for Disease Control and Prevention, 1600 Clifton Rd NE, Mailstop E 17, Atlanta, GA 30333
    JAMA 287:356-9. 2002
    ..Limited information is available about the prevalence of the metabolic syndrome in the United States, however...
  2. ncbi The structure of haplotype blocks in the human genome
    Stacey B Gabriel
    Whitehead MIT Center for Genome Research, Cambridge, MA 02139, USA
    Science 296:2225-9. 2002
    ..Our results provide a foundation for the construction of a haplotype map of the human genome, facilitating comprehensive genetic association studies of human disease...
  3. ncbi Race, breast cancer subtypes, and survival in the Carolina Breast Cancer Study
    Lisa A Carey
    Division of Hematology Oncology, School of Public Health, Department of Epidemiology, University of North Carolina Lineberger Comprehensive Cancer Center, Chapel Hill, NC 27599 7305, USA
    JAMA 295:2492-502. 2006
    ..Gene expression analysis has identified several breast cancer subtypes, including basal-like, human epidermal growth factor receptor-2 positive/estrogen receptor negative (HER2+/ER-), luminal A, and luminal B...
  4. pmc Sensitive detection of chromosomal segments of distinct ancestry in admixed populations
    Alkes L Price
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    PLoS Genet 5:e1000519. 2009
    ..the method empirically by applying it to populations that have experienced recent and ancient admixture: 935 African Americans from the United States and 29 Mozabites from North Africa...
  5. pmc A genome-wide association study of hypertension and blood pressure in African Americans
    Adebowale Adeyemo
    Center for Research on Genomics and Global Health, National Human Genome Research Institute, NIH, Bethesda, MD, USA
    PLoS Genet 5:e1000564. 2009
    ..genetic variants underlying blood pressure (BP) by conducting a genome-wide association study (GWAS) among African Americans, a population group in the United States that is disproportionately affected by hypertension and associated ..
  6. pmc The genetic structure and history of Africans and African Americans
    Sarah A Tishkoff
    Department of Biology, University of Maryland, College Park, MD 20742, USA
    Science 324:1035-44. 2009
    ..The ancestry of African Americans is predominantly from Niger-Kordofanian (approximately 71%), European (approximately 13%), and other African ..
  7. pmc Association of trypanolytic ApoL1 variants with kidney disease in African Americans
    Giulio Genovese
    Division of Nephrology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Science 329:841-5. 2010
    b>African Americans have higher rates of kidney disease than European Americans...
  8. pmc The contextual effect of the local food environment on residents' diets: the atherosclerosis risk in communities study
    Kimberly Morland
    Department of Epidemiology, University of North Carolina, Chapel Hill, USA
    Am J Public Health 92:1761-7. 2002
    ..We studied the association between the local food environment and residents' report of recommended dietary intake...
  9. pmc Demographic differences and trends of vitamin D insufficiency in the US population, 1988-2004
    Adit A Ginde
    Department of Emergency Medicine, University of Colorado Denver School of Medicine, Aurora, 80045, USA
    Arch Intern Med 169:626-32. 2009
    ..Vitamin D insufficiency is associated with suboptimal health. The prevalence of vitamin D insufficiency may be rising, but population-based trends are uncertain. We sought to evaluate US population trends in vitamin D insufficiency...
  10. pmc Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project
    Guillaume Lettre
    Montreal Heart Institute, Montreal, Canada
    PLoS Genet 7:e1001300. 2011
    Coronary heart disease (CHD) is the leading cause of mortality in African Americans. To identify common genetic polymorphisms associated with CHD and its risk factors (LDL- and HDL-cholesterol (LDL-C and HDL-C), hypertension, smoking, ..
  11. pmc The landscape of recombination in African Americans
    Anjali G Hinch
    Wellcome Trust Centre for Human Genetics, Oxford University, Roosevelt Drive, Oxford OX3 7BN, UK
    Nature 476:170-5. 2011
    ..1 million crossovers in 30,000 unrelated African Americans. At intervals of more than three megabases it is nearly identical to a map built in Europeans...
  12. ncbi Waist circumference percentiles in nationally representative samples of African-American, European-American, and Mexican-American children and adolescents
    Jose R Fernandez
    Section on Statistical Genetics, Department of Biostatistics, Clinical Nutrition Research Center, University of Alabama at Birmingham, 35294 3360, USA
    J Pediatr 145:439-44. 2004
    ..To describe and provide estimates of the distribution of waist circumference (WC) according to percentiles in African-, European-, and Mexican-American children, and to test for group differences at different percentiles...
  13. doi Tumor immunobiological differences in prostate cancer between African-American and European-American men
    Tiffany A Wallace
    Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892 4258, USA
    Cancer Res 68:927-36. 2008
    ..The profiles portray the existence of a distinct tumor microenvironment in these two patient groups...
  14. pmc Most common single-nucleotide polymorphisms associated with rheumatoid arthritis in persons of European ancestry confer risk of rheumatoid arthritis in African Americans
    Laura B Hughes
    University of Alabama at Birmingham, 1530 3rd Avenue South, SHEL 210, Birmingham, AL 35294 2182, USA
    Arthritis Rheum 62:3547-53. 2010
    ..The influence of these risk alleles has not been comprehensively studied in African Americans. We therefore sought to examine whether these validated RA risk alleles are associated with RA risk in an ..
  15. ncbi Differences in breast carcinoma characteristics in newly diagnosed African-American and Caucasian patients: a single-institution compilation compared with the National Cancer Institute's Surveillance, Epidemiology, and End Results database
    Gloria J Morris
    Department of Medical Oncology, Kimmel Cancer Center, Thomas Jefferson University Hospital, Philadelphia, PA 19107, USA
    Cancer 110:876-84. 2007
    ..Breast carcinomas in African-American patients appear to be more aggressive than in Caucasian patients due to multifactorial differences...
  16. ncbi State of disparities in cardiovascular health in the United States
    George A Mensah
    Office of the Director, Division of Adult and Community Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control, Mail Stop K 40, 4770 Buford Hwy NE, Atlanta, GA 30341 3717, USA
    Circulation 111:1233-41. 2005
    ..Having timely access to current data on disparities is important for policy and program development. Accordingly, we assessed the current magnitude of disparities in cardiovascular disease (CVD) and its risk factors in the United States...
  17. pmc Replication of genome-wide association studies (GWAS) loci for fasting plasma glucose in African-Americans
    E Ramos
    Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, 12 South Drive, MSC 5635, Bethesda, MD 20892, USA
    Diabetologia 54:783-8. 2011
    ..Thus, it is important to conduct replication analyses in populations with non-European ancestry to identify shared loci associated with FPG across populations...
  18. pmc A genome-wide association study of serum uric acid in African Americans
    Bashira A Charles
    Center for Research on Genomics and Global Health, National Human Genome Research Institute, Bethesda, MD 20892, USA
    BMC Med Genomics 4:17. 2011
    ....
  19. pmc Ancestry and pharmacogenomics of relapse in acute lymphoblastic leukemia
    Jun J Yang
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Nat Genet 43:237-41. 2011
    ..after childhood ALL have been reported in many clinical studies, with poorer survival observed among African Americans or those with Hispanic ethnicity when compared with European Americans or Asians...
  20. ncbi Race and gender differences in C-reactive protein levels
    Amit Khera
    Donald W Reynolds Cardiovascular Clinical Research Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9047, USA
    J Am Coll Cardiol 46:464-9. 2005
    ..This study sought to determine whether there are race and gender differences in the distribution of C-reactive protein (CRP) levels...
  21. pmc The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans
    Nancy L Saccone
    Department of Genetics, Washington University, St Louis, Missouri 63110, UA
    Cancer Res 69:6848-56. 2009
    ..The nonsynonymous SNP rs16969968, a known risk variant in populations of European-descent, is also significantly associated with risk in African-Americans. Additional SNPs contribute to risk in distinct ways in these two populations...
  22. pmc H.U.B city steps: methods and early findings from a community-based participatory research trial to reduce blood pressure among African Americans
    Jamie M Zoellner
    Department of Human Nutrition, Foods and Exercise, Virginia Tech, 1981 Kraft Drive 0913, Blacksburg, VA 24061, USA
    Int J Behav Nutr Phys Act 8:59. 2011
    ..This behavioral study describes the conceptual frameworks, methods, and early findings related to the reach, adoption, implementation, and effectiveness on primary blood pressure outcomes...
  23. pmc Genome-wide association of anthropometric traits in African- and African-derived populations
    Sun J Kang
    Department of Biostatistics and Epidemiology, Case Western Reserve University, Cleveland, OH 44106, USA
    Hum Mol Genet 19:2725-38. 2010
    ..Meta-analysis of this data set with additional studies in African-ancestry populations will be helpful to improve power to detect novel associations...
  24. doi Race and triple negative threats to breast cancer survival: a population-based study in Atlanta, GA
    Mary Jo Lund
    Department of Epidemiology, Rollins School of Public Health, Emory University, 1518 Clifton Road, NE, Atlanta, GA 30322, USA
    Breast Cancer Res Treat 113:357-70. 2009
    ..This study examines association of the ER/PR/HER2 subtypes with race and breast cancer survival...
  25. pmc Identification of a systemic lupus erythematosus susceptibility locus at 11p13 between PDHX and CD44 in a multiethnic study
    Christopher J Lessard
    Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    Am J Hum Genet 88:83-91. 2011
    ....
  26. pmc Fine-mapping of breast cancer susceptibility loci characterizes genetic risk in African Americans
    Fang Chen
    Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA
    Hum Mol Genet 20:4491-503. 2011
    ..we identified markers in four regions that better capture the association with breast cancer risk in African Americans as defined by the index signal (2q35, 5q11, 10q26 and 19p13)...
  27. pmc The impact of FADS genetic variants on ω6 polyunsaturated fatty acid metabolism in African Americans
    Rasika A Mathias
    Division of General Internal Medicine, Department of Medicine, The GeneSTAR Research Program, The Johns Hopkins University, Baltimore, MD 21224, USA
    BMC Genet 12:50. 2011
    ....
  28. doi Prevalence of obesity among US preschool children in different racial and ethnic groups
    Sarah E Anderson
    Division of Epidemiology, College of Public Health, The Ohio State University, B216 Starling Loving Hall, 320 W 10th Avenue, Columbus, OH 43210, USA
    Arch Pediatr Adolesc Med 163:344-8. 2009
    ..To estimate the prevalence of obesity in 5 major racial/ethnic groups in 4-year-old US children...
  29. pmc Differential effects of MYH9 and APOL1 risk variants on FRMD3 Association with Diabetic ESRD in African Americans
    Barry I Freedman
    Section on Nephrology, Department of Internal Medicine, Wake Forest School of Medicine, Winston Salem, North Carolina, USA
    PLoS Genet 7:e1002150. 2011
    ..APOL1 on chromosome 22 (c22) are powerfully associated with non-diabetic end-stage renal disease (ESRD) in African Americans (AAs)...
  30. ncbi Race-ethnicity-specific waist circumference cutoffs for identifying cardiovascular disease risk factors
    Shankuan Zhu
    Injury Research Center and Department of Family and Community Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Am J Clin Nutr 81:409-15. 2005
    ..However, WC cutoffs for other race-ethnicity groups remain unknown...
  31. ncbi Preterm low birth weight and periodontal disease among African Americans
    Ananda P Dasanayake
    Department of Epidemiology and Health Promotion, New York University College of Dentistry, 345 East 24th Street, New York, NY 10010, USA
    Dent Clin North Am 47:115-25, x-xi. 2003
    b>African Americans consistently experience higher rates of preterm and low birth weight (LBW) deliveries than do whites...
  32. pmc Accuracy of genome-wide imputation of untyped markers and impacts on statistical power for association studies
    Ke Hao
    Genetics Department, Rosetta Inpharmatics, a Wholly Owned Subsidiary of Merck and Co Inc, Seattle, Washington, USA
    BMC Genet 10:27. 2009
    ..Genome-wide imputation of untyped markers allows us to address these issues in a direct fashion...
  33. pmc Racial disparities in cancer survival among randomized clinical trials patients of the Southwest Oncology Group
    Kathy S Albain
    Department of Medicine, Loyola University Chicago Stritch School of Medicine, Maywood, IL, USA
    J Natl Cancer Inst 101:984-92. 2009
    ..Our objective was to determine whether racial disparities in survival exist among patients enrolled in consecutive trials conducted by the Southwest Oncology Group (SWOG)...
  34. pmc Evaluation of 11 breast cancer susceptibility loci in African-American women
    Wei Zheng
    Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt Ingram Cancer Center, Nashville, TN 37203 1738, USA
    Cancer Epidemiol Biomarkers Prev 18:2761-4. 2009
    ..The results from this study extend some of the recent GWAS findings to African-Americans and may guide future efforts to identify the causal variants for breast cancer...
  35. pmc Association of glycemic index and glycemic load with risk of incident coronary heart disease among Whites and African Americans with and without type 2 diabetes: the Atherosclerosis Risk in Communities study
    Dale S Hardy
    Division of Epidemiology, University of Texas School of Public Health, Houston, TX 77225, USA
    Ann Epidemiol 20:610-6. 2010
    In this study we examined whether high glycemic index (GI) and glycemic load (GL) diets are associated with increased risk of developing coronary heart disease (CHD) in Whites and African Americans with and without type 2 diabetes.
  36. pmc Leukocyte telomeres are longer in African Americans than in whites: the National Heart, Lung, and Blood Institute Family Heart Study and the Bogalusa Heart Study
    Steven C Hunt
    Cardiovascular Genetics Division, University of Utah School of Medicine, Salt Lake City, UT, USA NHLBI Family Heart Study
    Aging Cell 7:451-8. 2008
    Leukocyte telomere length (LTL) is ostensibly a bio-indicator of human aging. Here we report that African Americans have longer LTL than whites...
  37. ncbi Sociocultural correlates of menthol cigarette smoking among adult African Americans in Los Angeles
    Bruce Allen
    Charles R Drew University of Medicine and Science, Los Angeles, CA 90059, USA
    Nicotine Tob Res 9:447-51. 2007
    ..Results indicate that menthol smoking among adult African Americans is at least partly a consequence of a complex set of social and cultural norms...
  38. pmc FTO genetic variation and association with obesity in West Africans and African Americans
    Adebowale Adeyemo
    Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA
    Diabetes 59:1549-54. 2010
    ..However, data from populations of African ancestry are limited. We evaluated genetic variation in the FTO gene and investigated associations with obesity in West Africans and African Americans.
  39. ncbi Causes and prevalence of visual impairment among adults in the United States
    Nathan Congdon
    Wilmer Eye Institute, Wilmer 120, 600 N Wolfe Street, Baltimore, MD 21287, USA
    Arch Ophthalmol 122:477-85. 2004
    ..To estimate the cause-specific prevalence and distribution of blindness and low vision in the United States by age, race/ethnicity, and gender, and to estimate the change in these prevalence figures over the next 20 years...
  40. pmc Host determinants of HIV-1 control in African Americans
    Kimberly Pelak
    Center for Human Genome Variation, Duke University Medical School, Durham, North Carolina, USA
    J Infect Dis 201:1141-9. 2010
    ..a whole-genome association study of human immunodeficiency virus type 1 (HIV-1) set point among a cohort of African Americans (n = 515), and an intronic single-nucleotide polymorphism (SNP) in the HLA-B gene showed one of the ..
  41. ncbi Racial and ethnic differences in secular trends for childhood BMI, weight, and height
    David S Freedman
    Division of Nutrition and Physical Activity, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Obesity (Silver Spring) 14:301-8. 2006
    ..The prevalence of childhood overweight in the United States has markedly increased over the last 30 years. We examined differences in the secular trends for BMI, weight, and height among white, black, and Mexican-American children...
  42. pmc Frequency of EGFR and KRAS mutations in lung adenocarcinomas in African Americans
    J Matthew Reinersman
    Memorial Sloan Kettering Cancer Center, New York City, New York 10065, USA
    J Thorac Oncol 6:28-31. 2011
    ..KRAS mutations confer resistance to EGFR-tyrosine kinase inhibitors. The prevalence of these mutations in African American patients has not been thoroughly investigated...
  43. doi Ancestry informative marker panels for African Americans based on subsets of commercially available SNP arrays
    Arti Tandon
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genet Epidemiol 35:80-3. 2011
    Admixture mapping is a widely used method for localizing disease genes in African Americans. Most current methods for inferring ancestry at each locus in the genome use a few thousand single nucleotide polymorphisms (SNPs) that are very ..
  44. pmc Large-scale candidate gene analysis in whites and African Americans identifies IL6R polymorphism in relation to atrial fibrillation: the National Heart, Lung, and Blood Institute's Candidate Gene Association Resource (CARe) project
    Renate B Schnabel
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    Circ Cardiovasc Genet 4:557-64. 2011
    The genetic background of atrial fibrillation (AF) in whites and African Americans is largely unknown. Genes in cardiovascular pathways have not been systematically investigated.
  45. pmc Interactive effect of stressful life events and the serotonin transporter 5-HTTLPR genotype on posttraumatic stress disorder diagnosis in 2 independent populations
    Pingxing Xie
    Department of Genetics, Yale University School of Medicine, New Haven, CT, USA
    Arch Gen Psychiatry 66:1201-9. 2009
    ..Previous studies generally focused on its effect on depressive symptoms; little is known about its moderation of the development of posttraumatic stress disorder (PTSD)...
  46. pmc Differences in arachidonic acid levels and fatty acid desaturase (FADS) gene variants in African Americans and European Americans with diabetes or the metabolic syndrome
    Susan Sergeant
    The Center for Botanical Lipids and Inflammatory Disease Prevention, Wake Forest School of Medicine, Winston Salem, NC 27157, USA
    Br J Nutr 107:547-55. 2012
    ..Compared with European Americans (EAm), African Americans (AfAm) exhibited markedly higher serum levels of arachidonic acid (AA) (EAm 7·9 (sd 2·1), AfAm 9·8 (sd 1·..
  47. pmc A comprehensive genetic association study of Alzheimer disease in African Americans
    Mark W Logue
    Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    Arch Neurol 68:1569-79. 2011
    To evaluate the association of genetic variation with late-onset Alzheimer disease (AD) in African Americans, including genes implicated in recent genome-wide association studies of whites.
  48. pmc Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study
    Ervin R Fox
    Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA
    Hum Mol Genet 20:2273-84. 2011
    The prevalence of hypertension in African Americans (AAs) is higher than in other US groups; yet, few have performed genome-wide association studies (GWASs) in AA...
  49. pmc MYH9 is associated with nondiabetic end-stage renal disease in African Americans
    W H Linda Kao
    Department of Epidemiology, School of Medicine and Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21287, USA
    Nat Genet 40:1185-92. 2008
    As end-stage renal disease (ESRD) has a four times higher incidence in African Americans compared to European Americans, we hypothesized that susceptibility alleles for ESRD have a higher frequency in the West African than the European ..
  50. pmc Incidence of atrial fibrillation in whites and African-Americans: the Atherosclerosis Risk in Communities (ARIC) study
    Alvaro Alonso
    Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, 1300 S 2nd Street, Minneapolis, MN 55454 USA
    Am Heart J 158:111-7. 2009
    To define the incidence and cumulative risk of atrial fibrillation (AF) in a population-based cohort of whites and African Americans.
  51. pmc Polymorphic allele of human IRGM1 is associated with susceptibility to tuberculosis in African Americans
    Katherine Y King
    Department of Pediatrics, Section of Infectious Diseases, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS ONE 6:e16317. 2011
    ..Among African Americans, the TB cases were more likely to carry the CD-related T allele of rs10065172 (odds ratio of 1...
  52. pmc Candidate gene association resource (CARe): design, methods, and proof of concept
    Kiran Musunuru
    Broad Institute, Cambridge, MA 02142, USA
    Circ Cardiovasc Genet 3:267-75. 2010
    ..The goals of CARe include the discovery of new variants associated with traits using a candidate gene approach and the discovery of new variants using the genome-wide association mapping approach specifically in African Americans.
  53. pmc Genetic ancestry in lung-function predictions
    Rajesh Kumar
    Division of Allergy and Immunology, Children s Memorial Hospital, 2300 Children s Plaza, Box 60, Chicago IL 60614, USA
    N Engl J Med 363:321-30. 2010
    ....
  54. pmc Characterizing the admixed African ancestry of African Americans
    Fouad Zakharia
    Department of Genetics, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA
    Genome Biol 10:R141. 2009
    ..applied recently developed statistical and computational techniques to the question of African ancestry in African Americans by using data on more than 450,000 single-nucleotide polymorphisms (SNPs) genotyped in 94 Africans of ..
  55. pmc Nucleotide excision repair genes and risk of lung cancer among San Francisco Bay Area Latinos and African Americans
    Jeffrey S Chang
    Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA
    Int J Cancer 123:2095-104. 2008
    ..association between nucleotide excision repair (NER) variants and lung cancer risk have included Latinos and African Americans. We examine variants in 6 NER genes (ERCC2, ERCC4, ERCC5, LIG1, RAD23B and XPC) in association with primary ..
  56. ncbi A randomized controlled trial of weight reduction and exercise for diabetes management in older African-American subjects
    T D Agurs-Collins
    Division of Epidemiology and Cancer Control, Howard University Cancer Center, Washington, DC 20006, USA
    Diabetes Care 20:1503-11. 1997
    ..To evaluate a weight loss and exercise program designed to improve diabetes management in older African-Americans...
  57. ncbi Prevalence of knee symptoms and radiographic and symptomatic knee osteoarthritis in African Americans and Caucasians: the Johnston County Osteoarthritis Project
    Joanne M Jordan
    Thurston Arthritis Research Center and Department of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599 7280, USA
    J Rheumatol 34:172-80. 2007
    To report contemporary estimates of the prevalence of knee-related osteoarthritis (OA) outcomes in African Americans and Caucasians aged > or = 45 years.
  58. ncbi Social resources and cognitive decline in a population of older African Americans and whites
    L L Barnes
    Rush Alzheimer s Disease Center, Rush University Medical Center, Armour Academic Facility, 600 S Paulina, Suite 1038, Chicago, IL 60612, USA
    Neurology 63:2322-6. 2004
    ..To examine the relation of social resources and cognitive decline in older adults...
  59. ncbi Vitamin D deficiency in systemic lupus erythematosus
    Diane L Kamen
    Medical University of South Carolina, Charleston, SC, USA
    Autoimmun Rev 5:114-7. 2006
    ..Overall, 67% of the subjects were vitamin D deficient, with mean levels significantly lower among African Americans (15.9 ng/ml) compared to Caucasians (31.3 ng/ml)...
  60. pmc Differences in the tumor microenvironment between African-American and European-American breast cancer patients
    Damali N Martin
    Laboratory of Human Carcinogenesis, Center of Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 4:e4531. 2009
    ..We tested the hypothesis that intrinsic differences in the tumor biology may contribute to this cancer health disparity...
  61. ncbi Physical activity social support and middle- and older-aged minority women: results from a US survey
    A A Eyler
    Prevention Research Center, Saint Louis University School of Public Health, MO 63376, USA
    Soc Sci Med 49:781-9. 1999
    ..Research on the determinants of physical activity have indicated that social support is one of the strongest correlates, but little is known about this relation in important subgroups of middle and older-aged women...
  62. pmc Nicotinic acetylcholine receptor region on chromosome 15q25 and lung cancer risk among African Americans: a case-control study
    Christopher I Amos
    Department of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    J Natl Cancer Inst 102:1199-205. 2010
    ..Thus, among African American persons, multiple loci in the region of chromosome 15q25.1 appear to be strongly associated with lung cancer risk...
  63. pmc Prostate cancer risk from occupational exposure to polycyclic aromatic hydrocarbons interacting with the GSTP1 Ile105Val polymorphism
    Benjamin A Rybicki
    Department of Biostatistics and Research Epidemiology, Henry Ford Health System, Detroit, MI 48202, USA
    Cancer Detect Prev 30:412-22. 2006
    ..An Ile/Val polymorphism in codon 105 of GSTP1 affects its enzymatic activity toward PAH detoxification, a possible mechanism in prostate carcinogenesis...
  64. pmc Enhanced statistical tests for GWAS in admixed populations: assessment using African Americans from CARe and a Breast Cancer Consortium
    Bogdan Pasaniuc
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    PLoS Genet 7:e1001371. 2011
    ..ancestry, more recent studies often involve additional populations, including admixed populations such as African Americans and Latinos...
  65. ncbi Disparities in the availability of fruits and vegetables between racially segregated urban neighbourhoods
    Kimberly Morland
    Department of Community and Preventive Medicine, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1057, New York, NY 10029, USA
    Public Health Nutr 10:1481-9. 2007
    ..Therefore, the purpose of this study was to evaluate the availability and variety of produce located in two racially and economically diverse urban neighbourhoods...
  66. pmc ORMDL3 gene is associated with asthma in three ethnically diverse populations
    Joshua Galanter
    Lung Biology Center, Department of Medicine, Institute for Human Genetics, University of California, San Francisco, California 94143 2911, USA
    Am J Respir Crit Care Med 177:1194-200. 2008
    ..Independent replication of genetic associations in complex diseases, particularly in whole-genome association studies, is critical to confirm the association...
  67. pmc Resequencing and analysis of variation in the TCF7L2 gene in African Americans suggests that SNP rs7903146 is the causal diabetes susceptibility variant
    Nicholette D Palmer
    Department of Biochemistry, Wake Forest University, Winston Salem, North Carolina, USA
    Diabetes 60:662-8. 2011
    ..The aim of this study was to elucidate which variant in TCF7L2 confers diabetes susceptibility in African Americans.
  68. pmc Genetic differences between the determinants of lipid profile phenotypes in African and European Americans: the Jackson Heart Study
    Rahul C Deo
    Department of Genetics, Harvard Medical School, Boston, MA, USA
    PLoS Genet 5:e1000342. 2009
    ..To address this problem for cardiovascular phenotypes, we studied a cohort of 4,464 African Americans from the Jackson Heart Study (JHS), in whom we genotyped both a panel of 12 recently discovered genetic ..
  69. pmc Prehypertensive African-American women have preserved nitric oxide and renal function but high cardiovascular risk
    Deborah L Feairheller
    Hypertension, Molecular and Applied Physiology Laboratory, Department of Kinesiology, Temple University, Philadelphia, PA 19122, USA
    Kidney Blood Press Res 33:282-90. 2010
    ..The relationship between prehypertension, renal function, inflammation, and oxidative stress was examined...
  70. doi Blood pressure and hypertension in relation to levels of serum polychlorinated biphenyls in residents of Anniston, Alabama
    Alexey Goncharov
    Department of Environmental Health Sciences, School of Public Health, University at Albany, Rensselaer, New York 12144, USA
    J Hypertens 28:2053-60. 2010
    ..To determine risk factors for elevated blood pressure and hypertension in residents of Anniston, Alabama who live near a plant that manufactured polychlorinated biphenyls (PCBs)...
  71. pmc Evidence supports a faster growth rate and/or earlier transformation to clinically significant prostate cancer in black than in white American men, and influences racial progression and mortality disparity
    Isaac J Powell
    Wayne State University School of Medicine and Karmanos Cancer Institute, Detroit, Michigan, USA
    J Urol 183:1792-6. 2010
    ..We propose that a more rapid prostate cancer growth rate and/or earlier transformation from latent to aggressive prostate cancer in black than in white men contribute to this disparity...
  72. ncbi Coping and distress among women under treatment for early stage breast cancer: comparing African Americans, Hispanics and non-Hispanic Whites
    Jenifer L Culver
    Department of Psychology, University of Miami, Coral Gables, FL 33124 2070, USA
    Psychooncology 11:495-504. 2002
    ..Hispanics reported the highest levels of venting, African Americans reported the lowest levels...
  73. pmc Relationship of alcohol consumption and type of alcoholic beverage consumed with plasma lipid levels: differences between Whites and African Americans of the ARIC study
    Kelly A Volcik
    Human Genetics Center, University of Texas Health Science Center, Houston, TX 77030, USA
    Ann Epidemiol 18:101-7. 2008
    ..The influence of different types of alcoholic beverages on plasma lipid levels has been investigated to a lesser extent and in limited populations...
  74. ncbi Influence of socioeconomic and cultural factors on racial differences in late-stage presentation of breast cancer
    D R Lannin
    Department of Surgery, Leo W Jenkins Cancer Center, East Carolina University, Greenville, NC 27858, USA
    JAMA 279:1801-7. 1998
    ..Breast cancer mortality is higher among African American women than among white women in the United States, but the reasons for the racial difference are not known...
  75. ncbi Correlates of using dual methods for sexually transmitted diseases and pregnancy prevention among high-risk African-American female teens
    R A Crosby
    Rollins School of Public Health, Department of Behavioral Sciences and Health Education, Atlanta, Georgia 30322, USA
    J Adolesc Health 28:410-4. 2001
    ..To identify correlates of consistent dual-method use among African-American female adolescents at risk of sexually transmitted diseases (STDs) and pregnancy...
  76. ncbi Race-specific differences in endothelial function: predisposition of African Americans to vascular diseases
    Leszek Kalinowski
    Department of Biochemistry, Ohio University, Athens, OH 45701, USA
    Circulation 109:2511-7. 2004
    ..We hypothesized that the differences in endothelial NO/O2-/ONOO- metabolism may highlight the potential predisposition to endothelial dysfunction and cardiovascular complications prevalent in blacks...
  77. pmc The relation between body size perception and change in body mass index over 13 years: the Coronary Artery Risk Development in Young Adults (CARDIA) study
    Elizabeth Lynch
    Department of Preventive Medicine, Rush University, 1700 West Van Buren, Chicago, IL 60612, USA
    Am J Epidemiol 169:857-66. 2009
    ..12 vs. 0.27 BMI units; P = 0.04). Results for men showed fewer and weaker associations. When obese women perceive themselves as obese and feel that their body size is too large, they gain less weight over time...
  78. pmc FGFR2 variants and breast cancer risk: fine-scale mapping using African American studies and analysis of chromatin conformation
    Miriam S Udler
    Department of Public Health and Primary Care, University of Cambridge, UK
    Hum Mol Genet 18:1692-703. 2009
    ....
  79. pmc Regional differences in African Americans' high risk for stroke: the remarkable burden of stroke for Southern African Americans
    George Howard
    University of Alabama School of Public Health, Department of Biostatistics, Birmingham, AL 35294 0022, USA
    Ann Epidemiol 17:689-96. 2007
    The stroke mortality rate for African Americans aged 45 to 64 years is 3 to 4 times higher than for whites of the same age, with a decreasing black-to-white mortality ratio with increasing age...
  80. pmc Susceptibility genes in common complex kidney disease
    Jasmin Divers
    Division of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1053, USA
    Curr Opin Nephrol Hypertens 19:79-84. 2010
    ..A brief overview of methods for identifying gene variants is provided, along with genetic associations and new avenues under exploration...
  81. pmc The diet quality of rural older adults in the South as measured by healthy eating index-2005 varies by ethnicity
    Margaret R Savoca
    Department of Nutrition, University of North Carolina Greensboro, 309 Stone Bldg, Greensboro, NC 27402, USA
    J Am Diet Assoc 109:2063-7. 2009
    ..After controlling for age, sex, marital status, poverty status, and education, African Americans (n=136) had higher total HEI-2005 scores compared to American Indians (n=195) and non-Hispanic whites (n=304)..
  82. pmc Sequencing the IL4 locus in African Americans implicates rare noncoding variants in asthma susceptibility
    Gabe Haller
    Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA
    J Allergy Clin Immunol 124:1204-9.e9. 2009
    Common genetic variations in the IL4 gene have been associated with asthma and atopy in European and Asian populations, but not in African Americans.
  83. pmc Heroin addiction in African Americans: a hypothesis-driven association study
    O Levran
    The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY 10065, USA
    Genes Brain Behav 8:531-40. 2009
    ..This study was designed to identify gene variants associated with heroin addiction in African Americans. The emphasis was on genes involved in reward modulation, behavioral control, cognitive function, signal ..
  84. pmc Association of nicotine metabolite ratio and CYP2A6 genotype with smoking cessation treatment in African-American light smokers
    M K Ho
    Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada
    Clin Pharmacol Ther 85:635-43. 2009
    ..61, 95% CI 0.95-2.72, P = 0.08). The determination of the 3HC/COT ratio, and possibly CYP2A6 genotype, may be useful in the future for personalizing the choice of smoking cessation treatment in African-American light smokers...
  85. ncbi Does a six-month pedometer intervention improve physical activity and health among vulnerable African Americans? A feasibility study
    Jamie Zoellner
    Department of Human Nutrition, Foods, and Exercise, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA
    J Phys Act Health 7:224-31. 2010
    ..Race/ethnic-specific physical activity patterns and biological responses to physical activity is one of the most understudied, yet critical aspects related to the development and adoption of physical activity recommendations...
  86. pmc Candidate genes for non-diabetic ESRD in African Americans: a genome-wide association study using pooled DNA
    Meredith A Bostrom
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, NC 27157 1053, USA
    Hum Genet 128:195-204. 2010
    b>African Americans have increased susceptibility to non-diabetic (non-DM) forms of end-stage renal disease (ESRD) and extensive evidence supports a genetic contribution...
  87. pmc Genetic association analysis highlights new loci that modulate hematological trait variation in Caucasians and African Americans
    Ken Sin Lo
    Montreal Heart Institute, 5000 Belanger Street, Montreal, QC, H1T 1C8, Canada
    Hum Genet 129:307-17. 2011
    ..polymorphisms (SNPs) that capture variation in ~2,100 candidate genes in DNA of 23,439 Caucasians and 7,112 African Americans from five population-based cohorts...
  88. ncbi Sustained-release bupropion for smoking cessation in African Americans: a randomized controlled trial
    Jasjit S Ahluwalia
    Department of Preventive Medicine and Public Health, University of Kansas School of Medicine and Kansas Cancer Institute, Kansas City, KS 66160 7313, USA
    JAMA 288:468-74. 2002
    b>African Americans disproportionately experience greater smoking attributable morbidity and mortality...
  89. pmc A genome-wide association study for diabetic nephropathy genes in African Americans
    Caitrin W McDonough
    Program in Molecular Medicine and Translational Science, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Kidney Int 79:563-72. 2011
    ..0 chip to identify genes associated with diabetic nephropathy in African Americans. Association analysis was performed adjusting for admixture in 965 type 2 diabetic African American patients ..
  90. pmc Prostate cancer risk associated loci in African Americans
    Jianfeng Xu
    Center for Cancer Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Cancer Epidemiol Biomarkers Prev 18:2145-9. 2009
    ..However, studies with larger numbers of AA subjects are needed, and this will likely require a major collaborative effort to combine multiple AA study populations...
  91. doi Ethnic differences in pain, itch and thermal detection in response to topical capsaicin: African Americans display a notably limited hyperalgesia and neurogenic inflammation
    H Wang
    Department of Dermatology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Br J Dermatol 162:1023-9. 2010
    ..Topical application of capsaicin commonly produces burning, stinging and itching as well as hyperalgesia to heat stimuli via activation of transient receptor potential vanilloid subtype 1...
  92. pmc A trial of 3 interventions to promote colorectal cancer screening in African Americans
    Daniel S Blumenthal
    Department of Community Health and Preventive Medicine, Morehouse School of Medicine, 720 Westview Drive SW, Atlanta, GA 30310, USA
    Cancer 116:922-9. 2010
    ..For the current study, the authors tested 3 interventions that were intended to increase the rate of CRC screening among African Americans.
  93. ncbi Self-reported weight status and dieting in a cross-sectional sample of young adolescents: National Health and Nutrition Examination Survey III
    R S Strauss
    Division of Pediatric Gastroenterology and Nutrition, University of Medicine and Dentistry of New Jersey Robert Wood Johnson School of Medicine, New Brunswick 08903, USA
    Arch Pediatr Adolesc Med 153:741-7. 1999
    ..To explore the relationship of self-reported weight status and dieting to actual weight and height in a cross-sectional nationally representative sample of young adolescents...
  94. ncbi The influence of spiritual beliefs and practices on the treatment preferences of African Americans: a review of the literature
    Kimberly S Johnson
    Department of Medicine, Division of Geriatrics, Duke University Medical Center, DUMC Box 3003, Durham, NC 27710, USA
    J Am Geriatr Soc 53:711-9. 2005
    ..culture and is often cited as an explanation for the more-aggressive treatment preferences of some African Americans at the end of life...
  95. ncbi Issues in minority health: atherosclerosis and coronary heart disease in African Americans
    Luther T Clark
    Division of Cardiovascular Medicine, Department of Medicine, State University of New York Downstate Medical Center, Brooklyn, New York 11203, USA
    Med Clin North Am 89:977-1001, 994. 2005
    ..b>African Americans have the highest overall CHD mortality rate and the highest out-of-hospital coronary death rate of any ..
  96. pmc Clinicopathological features of colon polyps from African-Americans
    Mehdi Nouraie
    Department of Medicine and Cancer Center, Howard University College of Medicine, 2041 Georgia Avenue, NW, Washington, DC 20060, USA
    Dig Dis Sci 55:1442-9. 2010
    ..It is shown that 30% of the US adult population has adenomas. The potential risk of malignant transformation in adenomas differs by specific pathologic and clinical characteristics that we aimed to study in AAs...
  97. pmc Evaluation of group genetic ancestry of populations from Philadelphia and Dakar in the context of sex-biased admixture in the Americas
    Klara Stefflova
    Department of Biostatistics and Epidemiology, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 4:e7842. 2009
    ..Genetic ancestry may influence genetic association studies due to differences in individual admixture within recently admixed populations like African Americans.
  98. pmc A risk allele for focal segmental glomerulosclerosis in African Americans is located within a region containing APOL1 and MYH9
    Giulio Genovese
    Renal Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Kidney Int 78:698-704. 2010
    ..high incidence of focal segmental glomerulosclerosis (FSGS) and non-diabetic end-stage renal disease among African Americans. To further define risk alleles with FSGS we performed a genome-wide association analysis using more than ..
  99. pmc Differences between dual-method and non-dual-method protection use in a sample of young African American women residing in the Southeastern United States
    Jessica M Sales
    Department of Behavioral Science and Health Education, Emory University, Rollins School of Public Health, Atlanta, GA 30322, USA
    Arch Pediatr Adolesc Med 164:1125-31. 2010
    ..To characterize dual-method protection users and report the prevalence of dual-method use among young adult African American women residing in the Southeastern United States...
  100. pmc The causes of racial and ethnic differences in influenza vaccination rates among elderly Medicare beneficiaries
    Paul L Hebert
    Mount Sinai School of Medicine, Department of Health Policy, New York, NY, USA
    Health Serv Res 40:517-37. 2005
    ....
  101. ncbi Dietary intake and risk of coronary heart disease differ among ethnic subgroups of black Americans
    Kristie J Lancaster
    Department of Nutrition, Food Studies and Public Health, New York University, New York, NY 10012, USA
    J Nutr 136:446-51. 2006
    ..Future studies of diet and health should consider cultural differences within the Black population to better understand and reduce overall health disparities in the United States...

Research Grants99

  1. Genetic analysis fo metabolic syndrome by admixture mapping in African Americans
    Ludmila Pawlikowska; Fiscal Year: 2009
    ..We will identify genes related to metabolic syndrome by genetic mapping in African Americans, who have inherited different genetic variants from their African and European ancestors;these inheritance ..
  2. Etiological Studies of Gastric Carcinoma
    Pelayo Correa; Fiscal Year: 2005
    ..There are, however, high-risk groups, especially African Americans, Amerindians, and immigrants from Asia, Northern/Eastern Europe and Latin America...
  3. Etiological Studies of Gastric Carcinoma
    Pelayo Correa; Fiscal Year: 2003
    ..There are, however, high-risk groups, especially African Americans, Amerindians, and immigrants from Asia, Northern/Eastern Europe and Latin America...
  4. EFFICACY OF MOTIVATIONAL INTERVIEW TO LOWER DIABETES RISK IN AFRICAN AMERICANS
    LEWIS BLUE; Fiscal Year: 2011
    ..2005). For example, compared to whites, African Americans with diabetes are more likely to develop heart disease, peripheral vascular disease leading to lower limb ..
  5. K-Mg-citrate as a BP lowering agent in African Americans; role of natriuresis
    ROBERT FRANKLIN REILLY; Fiscal Year: 2010
    ..Multiple studies show that the prevalence of hypertension is increased in African Americans. Racial differences are even more pronounced for severe forms of hypertension, and severe consequences of ..
  6. K-Mg-citrate as a BP lowering agent in African Americans; role of natriuresis
    Robert Reilly; Fiscal Year: 2009
    ..Multiple studies show that the prevalence of hypertension is increased in African Americans. Racial differences are even more pronounced for severe forms of hypertension, and severe consequences of ..
  7. Ubiquitous Mobile Multimedia for Environmental Public Health Outreach and Social
    CESAR BANDERA; Fiscal Year: 2010
    ..65% of white adults in the United States searched online for health information in 2008 versus 51% of African Americans and 44% of Hispanics. An alternate mechanism with which to convey visual content (e.g...
  8. Diet and Gastrointestinal Cancer Risk in African Americans and Rural Africans
    STEPHEN O KEEFE; Fiscal Year: 2009
    ..We are concerned that the reason why African Americans (AAs) have the highest incidence (c1:70,000 of the population) and death rate from colon cancer in the USA ..
  9. Reasons for Racial Disparities in Venous Thromboembolism
    NEIL ADRIAN ZAKAI; Fiscal Year: 2010
    ..Though understanding the reasons for this disparity we can begin to formulate public health policies to address this disparity. ..
  10. Reasons for Racial Disparities in Venous Thromboembolism
    NEIL ZAKAI; Fiscal Year: 2009
    ..Though understanding the reasons for this disparity we can begin to formulate public health policies to address this disparity. ..
  11. JACKSON HEART STUDY
    HERMAN ALFRED TAYLOR; Fiscal Year: 2009
    ..abstract_text> ..
  12. JACKSON HEART STUDY
    HERMAN ALFRED TAYLOR; Fiscal Year: 2009
    ..abstract_text> ..
  13. JACKSON HEART STUDY
    ASOKA S SRINIVASAN; Fiscal Year: 2011
    ..abstract_text> ..
  14. JACKSON HEART STUDY
    Herman Taylor; Fiscal Year: 2010
    ..abstract_text> ..
  15. JACKSON HEART STUDY
    Asoka Srinivasan; Fiscal Year: 2010
    ..abstract_text> ..
  16. Exploring Patterns of Concurrency Among Urban African Americans
    Amy Stewart Nunn; Fiscal Year: 2010
    ..award explores patterns of concurrent sexual partnerships, or partnerships that overlap in time, among urban African Americans in Philadelphia...
  17. Polymorphism and mutation spectrum in minorities with non-small cell lung cancer
    David P Carbone; Fiscal Year: 2010
    ..The goal of this study is to determine the impact of perturbations in the EGFR pathway on genetic susceptibility, disease progression, and outcome in African-Americans with non-small cell lung cancer. ..
  18. AFRICAN AMERICAN STUDY OF KIDNEY DISEASE AND HYPERTENSION (AASK)
    Otelio Randall; Fiscal Year: 1999
    ..These two diseases are the major cause of morbidity and mortality in the United States, especially among African Americans. There is some preliminary evidence suggesting that some antihypertensive drugs may retard the progression ..
  19. AFRICAN AMERICAN STUDY OF KIDNEY DISEASE AND HYPERTENSION (AASK)
    Otelio Randall; Fiscal Year: 2000
    ..These two diseases are the major cause of morbidity and mortality in the United States, especially among African Americans. There is some preliminary evidence suggesting that some antihypertensive drugs may retard the progression ..
  20. HCV TREATMENT IN AFRICAN AMERICANS VS NON HISPANIC WHIT*
    Lennox Jeffers; Fiscal Year: 2004
    ..sustained virologic response to a 48-week course of Peginterferon alfa-2a in combination with ribavirin in African Americans as compared to non-Hispanic whites with chronic HCV genotype 1 as assessed at the end of 48-week post-..
  21. HCV TREATMENT IN AFRICAN AMERICANS VS NON HISPANIC WHIT*
    Lennox Jeffers; Fiscal Year: 2001
    ..sustained virologic response to a 48-week course of Peginterferon alfa-2a in combination with ribavirin in African Americans as compared to non-Hispanic whites with chronic HCV genotype 1 as assessed at the end of 48-week post-..
  22. HCV TREATMENT IN AFRICAN AMERICANS VS NON HISPANIC WHIT*
    Lennox Jeffers; Fiscal Year: 2005
    ..sustained virologic response to a 48-week course of Peginterferon alfa-2a in combination with ribavirin in African Americans as compared to non-Hispanic whites with chronic HCV genotype 1 as assessed at the end of 48-week post-..
  23. HCV TREATMENT IN AFRICAN AMERICANS VS NON HISPANIC WHIT*
    Lennox Jeffers; Fiscal Year: 2004
    ..sustained virologic response to a 48-week course of Peginterferon alfa-2a in combination with ribavirin in African Americans as compared to non-Hispanic whites with chronic HCV genotype 1 as assessed at the end of 48-week post-..
  24. HCV TREATMENT IN AFRICAN AMERICANS VS NON HISPANIC WHIT*
    Lennox Jeffers; Fiscal Year: 2003
    ..sustained virologic response to a 48-week course of Peginterferon alfa-2a in combination with ribavirin in African Americans as compared to non-Hispanic whites with chronic HCV genotype 1 as assessed at the end of 48-week post-..
  25. HCV TREATMENT IN AFRICAN AMERICANS VS NON HISPANIC WHIT*
    Lennox Jeffers; Fiscal Year: 2002
    ..sustained virologic response to a 48-week course of Peginterferon alfa-2a in combination with ribavirin in African Americans as compared to non-Hispanic whites with chronic HCV genotype 1 as assessed at the end of 48-week post-..
  26. Polymorphism and mutation spectrum in minorities with non-small cell lung cancer
    David Carbone; Fiscal Year: 2009
    ..The goal of this study is to determine the impact of perturbations in the EGFR pathway on genetic susceptibility, disease progression, and outcome in African-Americans with non-small cell lung cancer. ..
  27. Genetic contributors to diabetes and dyslipidemia in African Americans
    Michele Sale; Fiscal Year: 2009
    DESCRIPTION (provided by principal investigator): It is estimated that 3.2 million African Americans aged 20 years or older have T2DM...
  28. Genetic contributors to diabetes and dyslipidemia in African Americans
    Michele M Sale; Fiscal Year: 2010
    DESCRIPTION (provided by principal investigator): It is estimated that 3.2 million African Americans aged 20 years or older have T2DM...
  29. Genetic contributors to diabetes and dyslipidemia in African Americans
    Michele M Sale; Fiscal Year: 2010
    DESCRIPTION (provided by principal investigator): It is estimated that 3.2 million African Americans aged 20 years or older have T2DM...
  30. Inflammation and Sub-Clinical Renal Damage in Cocaine-Dependent African Americans
    ELIZABETH NESMITH; Fiscal Year: 2009
    ..The overall goal of this project is to examine the effects of cocaine dependency on renal physiology in African Americans (AAs)...
  31. Self-Management in African Americans with Diabetes and Hypertension
    Cheryl Rucker Whitaker; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  32. Arterial Baroreflex Function in African Americans at Rest and During Exercise
    David Keller; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): African Americans are at higher risk than their Caucasian American counterparts for the development of hypertension with hypertension affecting over 40% of the African American adult population...
  33. Does Enhanced School-Readiness Affect Adult Health of African Americans?
    Frances A Campbell; Fiscal Year: 2010
    ..NIH Challenge Grants in Health and Science Research Does Enhanced School-Readiness Affect Adult Health of African Americans? This application addresses Broad Challenge Area (05) Comparative Effectiveness Research, 05-MD-101, Social ..
  34. Does Enhanced School-Readiness Affect Adult Health of African Americans?
    FRANCES CAMPBELL; Fiscal Year: 2009
    ..NIH Challenge Grants in Health and Science Research Does Enhanced School-Readiness Affect Adult Health of African Americans? This application addresses Broad Challenge Area (05) Comparative Effectiveness Research, 05-MD-101, Social ..
  35. Transplant Social Worker Support for Live Kidney Donation in African Americans
    LEIGH E BOULWARE; Fiscal Year: 2012
    ..However, African Americans have been persistently and significantly less likely to receive LDKT when compared to Whites...
  36. Genome Wide Admixture Scan for Multiple Myeloma in African Americans
    CHRISTOPHER ALAN HAIMAN; Fiscal Year: 2010
    ..Despite recent advances in treatment, the 5-year survival rate remains under 40%. African Americans experience incidence rates over 2-fold higher than those of Whites;the reasons for the racial differences in ..
  37. Ethnic Differences in Responses to Painful Stimuli
    Roger Fillingim; Fiscal Year: 2009
    ..pain sensitivity, endogenous pain inhibition, clinical pain and pain-related disability among older African Americans and non-Hispanic whites with knee osteoarthritis (OA);2) to determine ethnic group differences in biological,..
  38. VIRAHEP-C Clinical Center
    Anna Lok; Fiscal Year: 2005
    ..7 million Americans have evidence of chronic infection. The prevalence of antibody to HCV is higher among African Americans (3.2%) than among the non-Hispanic whites (1.8%)...
  39. VIRAHEP-C Clinical Center
    Hari Conjeevaram; Fiscal Year: 2004
    ..7 million Americans have evidence of chronic infection. The prevalence of antibody to HCV is higher among African Americans (3.2%) than among the non-Hispanic whites (1.8%)...
  40. VIRAHEP-C Clinical Center
    Hari Conjeevaram; Fiscal Year: 2003
    ..7 million Americans have evidence of chronic infection. The prevalence of antibody to HCV is higher among African Americans (3.2%) than among the non-Hispanic whites (1.8%)...
  41. VIRAHEP-C Clinical Center
    Hari Conjeevaram; Fiscal Year: 2002
    ..7 million Americans have evidence of chronic infection. The prevalence of antibody to HCV is higher among African Americans (3.2%) than among the non-Hispanic whites (1.8%)...
  42. VIRAHEP-C Clinical Center
    Hari Conjeevaram; Fiscal Year: 2001
    ..7 million Americans have evidence of chronic infection. The prevalence of antibody to HCV is higher among African Americans (3.2%) than among the non-Hispanic whites (1.8%)...
  43. THE AGING OF BLACK VETERANS
    DORA COSTA; Fiscal Year: 2002
    ..The findings will also help forecast future retirement, mortality, and disability trends that will aid in the development of health and pension policies. ..
  44. THE AGING OF BLACK VETERANS
    DORA COSTA; Fiscal Year: 2001
    ..The findings will also help forecast future retirement, mortality, and disability trends that will aid in the development of health and pension policies. ..
  45. Intensive Outpatient v. Outpatient Treatment with Buprenorphine among African Ame
    Shannon Gwin Mitchell; Fiscal Year: 2010
    ..Populations Background: Although there is relatively little difference in illicit drug use rates between African Americans and Whites, there is are significant differences in terms of the collateral impact of opiate use on these ..
  46. Intensive Outpatient v. Outpatient Treatment with Buprenorphine among African Ame
    Shannon Mitchell; Fiscal Year: 2009
    ..Populations Background: Although there is relatively little difference in illicit drug use rates between African Americans and Whites, there is are significant differences in terms of the collateral impact of opiate use on these ..
  47. Disparities in CHD in the Jackson Heart Study
    Mario Sims; Fiscal Year: 2006
    ..key psychosocial factors (discrimination, stress, and social support) impact coronary heart disease (CHD) in African Americans in Mississippi...
  48. Disparities in CHD in the Jackson Heart Study
    Mario Sims; Fiscal Year: 2010
    ..key psychosocial factors (discrimination, stress, and social support) impact coronary heart disease (CHD) in African Americans in Mississippi...
  49. Disparities in CHD in the Jackson Heart Study
    Mario Sims; Fiscal Year: 2009
    ..key psychosocial factors (discrimination, stress, and social support) impact coronary heart disease (CHD) in African Americans in Mississippi...
  50. Disparities in CHD in the Jackson Heart Study
    Mario Sims; Fiscal Year: 2007
    ..key psychosocial factors (discrimination, stress, and social support) impact coronary heart disease (CHD) in African Americans in Mississippi...
  51. Resistance to Antiviral Therapy in Chronic Hepatitis C
    Norah Terrault; Fiscal Year: 2002
    ..virological response (viral clearance) to pegylated interferon plus ribavirin will be compared in 200 African Americans and 200 non-Hispanic whites...
  52. Resistance to Antiviral Therapy in Chronic Hepatitis C
    Norah Terrault; Fiscal Year: 2001
    ..virological response (viral clearance) to pegylated interferon plus ribavirin will be compared in 200 African Americans and 200 non-Hispanic whites...
  53. PHARMACOKINETICS AND PHARMACODYNAMICS OF NICOTINE
    Neal L Benowitz; Fiscal Year: 2010
    ..An ultimate objective is to use this knowledge to aid in the development of more effective smoking cessation interventions for African-Americans. ..
  54. Resistance to Antiviral Therapy in Chronic Hepatitis C
    Norah Terrault; Fiscal Year: 2003
    ..virological response (viral clearance) to pegylated interferon plus ribavirin will be compared in 200 African Americans and 200 non-Hispanic whites...
  55. Resistance to Antiviral Therapy in Chronic Hepatitis C
    Norah Terrault; Fiscal Year: 2004
    ..virological response (viral clearance) to pegylated interferon plus ribavirin will be compared in 200 African Americans and 200 non-Hispanic whites...
  56. Resistance to Antiviral Therapy in Chronic Hepatitis C
    Norah Terrault; Fiscal Year: 2005
    ..virological response (viral clearance) to pegylated interferon plus ribavirin will be compared in 200 African Americans and 200 non-Hispanic whites...
  57. PHARMACOKINETICS AND PHARMACODYNAMICS OF NICOTINE
    Neal Benowitz; Fiscal Year: 2009
    ..An ultimate objective is to use this knowledge to aid in the development of more effective smoking cessation interventions for African-Americans. ..
  58. The contribution of common and rare variants to autoimmunity in African Americans
    Jorge R Oksenberg; Fiscal Year: 2011
    ..Our overall goal is to contribute to the understanding of MS pathogenesis by means of genetic research in African Americans. The distinct genetic architecture of this population, together with the differences in MS risk (and ..
  59. Promoting "Stories of Success": Enhancing Diabetes Self-Care
    Sharon Utz; Fiscal Year: 2009
    ..by applicant): Type 2 diabetes mellitus (T2DM) is a serious health problem that disproportionately affects African Americans who have a nation-wide prevalence of 13.3% compared to 8.7% among adults overall...
  60. Genetic analysis fo metabolic syndrome by admixture mapping in African Americans
    Ludmila Pawlikowska; Fiscal Year: 2010
    ..We will identify genes related to metabolic syndrome by genetic mapping in African Americans, who have inherited different genetic variants from their African and European ancestors;these inheritance ..
  61. Application and Dissemination of a Culture-Centered Approach to Tailoring Compara
    Mohan Jyoti Dutta; Fiscal Year: 2010
    ..The proposed project specifically seeks to develop tailored CERSGs on heart disease targeted toward African Americans in Indiana, given the existing disparities among racial/ethnic groups in the area of heart disease, and the ..
  62. Disparities in Progression to Renal Replacement Therapy
    Stephen Derose; Fiscal Year: 2009
    ..It has long been recognized that African Americans are much more likely to experience end-stage renal disease (ESRD)...
  63. Disparities in Progression to Renal Replacement Therapy
    Stephen F Derose; Fiscal Year: 2010
    ..It has long been recognized that African Americans are much more likely to experience end-stage renal disease (ESRD)...
  64. Genetics of Hypertension Risk Factors and Sequela in African Americans
    Yan Sun; Fiscal Year: 2009
    ..broad Challenge Area (08) Genomics and specific Challenge Topic, 08-HL-104: Assess genetic variation in African Americans and determine its effect on disease...
  65. A web-based tailored health behavior intervention for African American colon canc
    Marlyn Allicock; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Background African Americans experience disproportionate morbidity and mortality from colon and rectal cancers...
  66. Genetics of Hypertension Risk Factors and Sequela in African Americans
    Yan Sun; Fiscal Year: 2010
    ..broad Challenge Area (08) Genomics and specific Challenge Topic, 08-HL-104: Assess genetic variation in African Americans and determine its effect on disease...
  67. Admixture Mapping of Sarcoidosis Genes in African American
    Benjamin Rybicki; Fiscal Year: 2009
    ..As a research group that has extensively studied the genetic susceptibility of sarcoidosis in African Americans, we have accumulated DMA samples for 1,302 African-American sarcoidosis cases...
  68. Admixture Mapping of Sarcoidosis Genes in African American
    Benjamin A Rybicki; Fiscal Year: 2010
    ..As a research group that has extensively studied the genetic susceptibility of sarcoidosis in African Americans, we have accumulated DMA samples for 1,302 African-American sarcoidosis cases...
  69. Racial Differences in IFN Transcriptional Response
    Daryl Lau; Fiscal Year: 2007
    ..Approximately 2.4 million Americans have chronic hepatitis C infection and the rate is higher among the African Americans (3.2%) than among the Caucasian population (1.5%)...
  70. Information and Financial Interventions for Kidney Donation in African Americans
    LEIGH BOULWARE; Fiscal Year: 2007
    b>African Americans are less likely than Whites to receive kidney transplants, despite their being more than two-fold as likely as Whites to develop end stage renal disease (ESRD)...
  71. Racial Differences in IFN Transcriptional Response
    Daryl Lau; Fiscal Year: 2005
    ..Approximately 2.4 million Americans have chronic hepatitis C infection and the rate is higher among the African Americans (3.2%) than among the Caucasian population (1.5%)...
  72. Racial Differences in IFN Transcriptional Response
    Daryl Lau; Fiscal Year: 2009
    ..Approximately 2.4 million Americans have chronic hepatitis C infection and the rate is higher among the African Americans (3.2%) than among the Caucasian population (1.5%)...
  73. Racial Differences in IFN Transcriptional Response
    Daryl Lau; Fiscal Year: 2006
    ..Approximately 2.4 million Americans have chronic hepatitis C infection and the rate is higher among the African Americans (3.2%) than among the Caucasian population (1.5%)...
  74. Information and Financial Interventions for Kidney Donation in African Americans
    LEIGH BOULWARE; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): African Americans are less likely than Whites to receive kidney transplants, despite their being more than two-fold as likely as Whites to develop end stage renal disease (ESRD)...
  75. Information and Financial Interventions for Kidney Donation in African Americans
    LEIGH BOULWARE; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): African Americans are less likely than Whites to receive kidney transplants, despite their being more than two-fold as likely as Whites to develop end stage renal disease (ESRD)...
  76. Parathyroid Hormone & Vitamin D Effects on Salt Sensitivity and Vascular Function
    ANNA LIZA BELEN VALINA TOTH; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Vitamin D deficiency is much more common in African Americans than whites...
  77. Parathyroid Hormone & Vitamin D Effects on Salt Sensitivity and Vascular Function
    ANNA LIZA VALINA TOTH; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Vitamin D deficiency is much more common in African Americans than whites...
  78. Admixture Mapping of Glaucoma Genes in African Americans
    Michael Hauser; Fiscal Year: 2009
    Primary open angle glaucoma (POAG) is a leading cause of blindness. This disease disproportionately affects African Americans, who have a four- to five-fold higher risk of disease than age-matched Caucasians...
  79. Admixture Mapping of Glaucoma Genes in African Americans
    Michael Hauser; Fiscal Year: 2009
    Primary open angle glaucoma (POAG) is a leading cause of blindness. This disease disproportionately affects African Americans, who have a four- to five-fold higher risk of disease than age-matched Caucasians...
  80. Admixture Mapping of Glaucoma Genes in African Americans
    Michael A Hauser; Fiscal Year: 2010
    Primary open angle glaucoma (POAG) is a leading cause of blindness. This disease disproportionately affects African Americans, who have a four- to five-fold higher risk of disease than age-matched Caucasians...
  81. Accelerated Repair of Vascular Injury in Diabetes by TGF-beta Modified Stem Cells
    STEPHEN BARTELMEZ; Fiscal Year: 2009
    ..Our focus is to demonstrate proof of principle that adult HSC can be effectively used to repair infarcted coronary vessels and eventually greatly improve the quality and duration of these patient's lives. ..
  82. Development of a Quantitative and Sensitive Liquid Chromatographic/Mass Spectrome
    DERRICK SWINTON; Fiscal Year: 2009
    Studies conclude that the cessation rates amongst African Americans are lower than White Americans despite the fact that this group smokes fewer cigarettes per day than White Americans (1-4)...
  83. NUTRITION EDUCATION IN URBAN AFRICAN AMERICANS
    Diane Becker; Fiscal Year: 1992
    ..The overall goal is to achieve a significant increase in the proportion of African Americans consuming a low fat, low salt "prudent" diet and to increase the proportion with optimal levels of blood ..
  84. A Program to Increase Living Donations in African Americans
    Prabhakar Baliga; Fiscal Year: 2007
    South Carolina (SC) has one of the highest rates of end stage renal disease among African Americans (AA)...
  85. A Program to Increase Living Donations in African Americans
    Prabhakar Baliga; Fiscal Year: 2009
    South Carolina (SC) has one of the highest rates of end stage renal disease among African Americans (AA)...
  86. Cost Effectiveness of a Home Support Program for Depression in Black Elders
    Laura N Gitlin; Fiscal Year: 2010
    ..of our currently funded randomized controlled trial (NIMH R01MH079814) "Treating Depression in Older African Americans") that tests a novel 10- session home-based intervention to treat depression in older community-dwelling ..
  87. Cost Effectiveness of a Home Support Program for Depression in Black Elders
    Laura Gitlin; Fiscal Year: 2009
    ..of our currently funded randomized controlled trial (NIMH R01MH079814) "Treating Depression in Older African Americans") that tests a novel 10- session home-based intervention to treat depression in older community-dwelling ..
  88. Ethnic/Racial Variation in Intracerebral Hemorrhage (ERICH)
    Daniel Woo; Fiscal Year: 2010
    ..Yet we know little about the biologic differences that lead to this ethnic disparity. Our proposal will compare minorities with ICH to controls from the same population as well as explore genetic, radiographic and outcomes differences. ..
  89. HIV EPIDEMIOLOGY AMONG RURAL AFRICAN-AMERICANS
    Adaora Adimora; Fiscal Year: 1999
    HIV infection has emerged as a major public health problem among African Americans in rural regions of the Southeastern United States, where the epidemics of gonorrhea, syphilis, and other curable STDs have also escalated...
  90. Measurement of Sedentary Behavior in African American Adults
    Robert Newton; Fiscal Year: 2009
    ..It has been shown that African Americans spend more time engaged in sedentary behaviors than do their Caucasian counterparts (Sidney et al, 1996;..
  91. Measurement of Sedentary Behavior in African American Adults
    ROBERT LEE NEWTON; Fiscal Year: 2010
    ..It has been shown that African Americans spend more time engaged in sedentary behaviors than do their Caucasian counterparts (Sidney et al, 1996;..
  92. Patient Centered Depression Care for African-Americans
    Lisa Cooper; Fiscal Year: 2003
    ..the Applicant) Several studies document underutilization of outpatient specialty mental health services by African Americans. However, African Americans with depression are just as likely as whites to receive care in primary care ..
  93. Patient Centered Depression Care for African-Americans
    Lisa Cooper; Fiscal Year: 2005
    ..the Applicant) Several studies document underutilization of outpatient specialty mental health services by African Americans. However, African Americans with depression are just as likely as whites to receive care in primary care ..
  94. Feasibility of Expert System to Promote African American Blood Donation for SCD
    Mark Robbins; Fiscal Year: 2009
    ..test the feasibility of an innovative, individualized intervention to increase blood donation rates among African Americans. Red blood cell transfusions are used to treat and to prevent some of the complications of Sickle Cell ..