Genomes and Genes
european continental ancestry group
Summary: Individuals whose ancestral origins are in the continent of Europe.
Publications286 found, 100 shown here
- Biological, clinical and population relevance of 95 loci for blood lipidsTanya M Teslovich
Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA
Nature 466:707-13. 2010..Taken together, our findings provide the foundation to develop a broader biological understanding of lipoprotein metabolism and to identify new therapeutic opportunities for the prevention of CAD...
- An abundance of rare functional variants in 202 drug target genes sequenced in 14,002 peopleMatthew R Nelson
Department of Quantitative Sciences, GlaxoSmithKline GSK, Research Triangle Park, NC 27709, USA
Science 337:100-4. 2012..We conclude that because of rapid population growth and weak purifying selection, human populations harbor an abundance of rare variants, many of which are deleterious and have relevance to understanding disease risk...
- The structure of haplotype blocks in the human genomeStacey B Gabriel
Whitehead MIT Center for Genome Research, Cambridge, MA 02139, USA
Science 296:2225-9. 2002..Our results provide a foundation for the construction of a haplotype map of the human genome, facilitating comprehensive genetic association studies of human disease...
- Recent explosive human population growth has resulted in an excess of rare genetic variantsAlon Keinan
Department of Biological Statistics and Computational Biology, Cornell University, Ithaca, NY 14853, USA
Science 336:740-3. 2012..Hence, the extreme recent human population growth needs to be taken into consideration in studying the genetics of complex diseases and traits...
- Loci influencing lipid levels and coronary heart disease risk in 16 European population cohortsYurii S Aulchenko
1 Department of Epidemiology and Biostatistics, Erasmus University Medical Center, P O Box 2040, 3000 CA Rotterdam, The Netherlands 2 These authors contributed equally to this work
Nat Genet 41:47-55. 2009..001) and coronary heart disease incidence (P = 0.04). The genetic risk score improves the screening of high-risk groups of dyslipidemia over classical risk factors...
- Validation of the Framingham coronary heart disease prediction scores: results of a multiple ethnic groups investigationR B D'Agostino
Department of Mathematics and Statistics, Boston University, 111 Cummington St, Boston, MA 02215, USA
JAMA 286:180-7. 2001..Concern exists regarding whether these functions can be generalized to other populations...
- Assessing the evolutionary impact of amino acid mutations in the human genomeAdam R Boyko
Department of Biological Statistics and Computational Biology, Cornell University, Ithaca, New York, USA
PLoS Genet 4:e1000083. 2008....
- Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancersHisayuki Shigematsu
Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, TX 75390 8593, USA
J Natl Cancer Inst 97:339-46. 2005..However, the role of such mutations in the pathogenesis of lung cancers is unclear...
- Sequence variations in PCSK9, low LDL, and protection against coronary heart diseaseJonathan C Cohen
Donald W Reynolds Cardiovascular Clinical Research Center, University of Texas Southwestern Medical Center, Dallas, TX 75390 9046, USA
N Engl J Med 354:1264-72. 2006..We examined the effect of DNA-sequence variations that reduce plasma levels of LDL cholesterol on the incidence of coronary events in a large population...
- The contextual effect of the local food environment on residents' diets: the atherosclerosis risk in communities studyKimberly Morland
Department of Epidemiology, University of North Carolina, Chapel Hill, USA
Am J Public Health 92:1761-7. 2002..We studied the association between the local food environment and residents' report of recommended dietary intake...
- Waist circumference percentiles in nationally representative samples of African-American, European-American, and Mexican-American children and adolescentsJose R Fernandez
Section on Statistical Genetics, Department of Biostatistics, Clinical Nutrition Research Center, University of Alabama at Birmingham, 35294 3360, USA
J Pediatr 145:439-44. 2004..To describe and provide estimates of the distribution of waist circumference (WC) according to percentiles in African-, European-, and Mexican-American children, and to test for group differences at different percentiles...
- SLC24A5, a putative cation exchanger, affects pigmentation in zebrafish and humansRebecca L Lamason
Jake Gittlen Cancer Research Foundation, Department of Pathology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
Science 310:1782-6. 2005....
- Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination SurveyEarl S Ford
Centers for Disease Control and Prevention, 1600 Clifton Rd NE, Mailstop E 17, Atlanta, GA 30333
JAMA 287:356-9. 2002..Limited information is available about the prevalence of the metabolic syndrome in the United States, however...
- The metabolic syndrome: prevalence and associated risk factor findings in the US population from the Third National Health and Nutrition Examination Survey, 1988-1994Yong Woo Park
Department of Family Medicine, Sungkyunkwan University School of Medicine, Seoul, Korea
Arch Intern Med 163:427-36. 2003..The extent to which the metabolic syndrome is associated with demographic and potentially modifiable lifestyle factors in the US population is unknown...
- Genetics of gene expression and its effect on diseaseValur Emilsson
deCODE Genetics, 101 Reykjavik, Iceland
Nature 452:423-8. 2008..A core network module in humans and mice was identified that is enriched for genes involved in the inflammatory and immune response and has been found to be causally associated to obesity-related traits...
- Demographic differences and trends of vitamin D insufficiency in the US population, 1988-2004Adit A Ginde
Department of Emergency Medicine, University of Colorado Denver School of Medicine, Aurora, 80045, USA
Arch Intern Med 169:626-32. 2009..Vitamin D insufficiency is associated with suboptimal health. The prevalence of vitamin D insufficiency may be rising, but population-based trends are uncertain. We sought to evaluate US population trends in vitamin D insufficiency...
- Asians are different from Caucasians and from each other in their body mass index/body fat per cent relationshipP Deurenberg
Wageningen University, The Netherlands
Obes Rev 3:141-6. 2002..Hence, the relationship between BF% and BMI is ethnic-specific. For comparisons of obesity prevalence between ethnic groups, universal BMI cut-off points are not appropriate...
- Ancestry informative marker sets for determining continental origin and admixture proportions in common populations in AmericaRoman Kosoy
Rowe Program in Human Genetics, Department of Biochemistry, University of California Davis, Davis, California 95616, USA
Hum Mutat 30:69-78. 2009..We conclude that investigators can use TaqMan assays for the selected AIMs as a simple and cost efficient tool to control for differences in continental ancestry when conducting association studies in ethnically diverse populations...
- Causes and prevalence of visual impairment among adults in the United StatesNathan Congdon
Wilmer Eye Institute, Wilmer 120, 600 N Wolfe Street, Baltimore, MD 21287, USA
Arch Ophthalmol 122:477-85. 2004..To estimate the cause-specific prevalence and distribution of blindness and low vision in the United States by age, race/ethnicity, and gender, and to estimate the change in these prevalence figures over the next 20 years...
- Mitochondrial DNA signals of late glacial recolonization of Europe from near eastern refugiaMaria Pala
School of Applied Sciences, University of Huddersfield, Queensgate, Huddersfield, UK
Am J Hum Genet 90:915-24. 2012....
- Genetic variants influencing circulating lipid levels and risk of coronary artery diseaseDawn M Waterworth
Genetics Division, GlaxoSmithKline R and D, King of Prussia, PA, USA
Arterioscler Thromb Vasc Biol 30:2264-76. 2010..We therefore conducted a genome-wide association study to identify novel genetic determinants of low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglycerides...
- Tumor immunobiological differences in prostate cancer between African-American and European-American menTiffany A Wallace
Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892 4258, USA
Cancer Res 68:927-36. 2008..The profiles portray the existence of a distinct tumor microenvironment in these two patient groups...
- A genome-wide association study of lung cancer identifies a region of chromosome 5p15 associated with risk for adenocarcinomaMaria Teresa Landi
Division of Cancer Epidemiology, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
Am J Hum Genet 85:679-91. 2009..In conclusion, a lung cancer GWAS identified a distinct hereditary contribution to adenocarcinoma...
- Origins and genetic legacy of Neolithic farmers and hunter-gatherers in EuropePontus Skoglund
Department of Evolutionary Biology, Evolutionary Biology Centre, Uppsala University, Uppsala, Sweden
Science 336:466-9. 2012..Our results suggest that migration from southern Europe catalyzed the spread of agriculture and that admixture in the wake of this expansion eventually shaped the genomic landscape of modern-day Europe...
- Type 2 diabetes risk alleles demonstrate extreme directional differentiation among human populations, compared to other diseasesRong Chen
Division of Systems Medicine, Department of Pediatrics, Stanford University School of Medicine, Stanford, California, United States of America
PLoS Genet 8:e1002621. 2012..Our results indicate that the differential frequencies of T2D risk alleles may contribute to the observed disparity in T2D incidence rates across ethnic populations...
- The relationship of waist circumference and BMI to visceral, subcutaneous, and total body fat: sex and race differencesSarah M Camhi
Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA
Obesity (Silver Spring) 19:402-8. 2011..Sex differences, and in some instances race differences, in the relationships between anthropometry and fat-specific depots demonstrate that these characteristics need to be considered when predicting adiposity from WC or BMI...
- Novel breast cancer susceptibility locus at 9q31.2: results of a genome-wide association studyOlivia Fletcher
Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK
J Natl Cancer Inst 103:425-35. 2011..Genome-wide association studies have identified several common genetic variants associated with breast cancer risk. It is likely, however, that a substantial proportion of such loci have not yet been discovered...
- Multifactor-dimensionality reduction reveals high-order interactions among estrogen-metabolism genes in sporadic breast cancerM D Ritchie
Program in Human Genetics, Department of Molecular Physiology and Biophysics, Vanderbilt University Medical School, Nashville, TN 37232, USA
Am J Hum Genet 69:138-47. 2001..To our knowledge, this is the first report of a four-locus interaction associated with a common complex multifactorial disease...
- Genetic discontinuity between local hunter-gatherers and central Europe's first farmersB Bramanti
Institute for Anthropology, University of Mainz, Mainz, Germany
Science 326:137-40. 2009..Together, these analyses provide persuasive evidence that the first farmers were not the descendants of local hunter-gatherers but immigrated into central Europe at the onset of the Neolithic...
- Epidemiology of basal-like breast cancerRobert C Millikan
Department of Epidemiology, CB 7435, School of Public Health, University of North Carolina, Chapel Hill, NC 27599 7435, USA
Breast Cancer Res Treat 109:123-39. 2008..Among younger African-American women, we estimate that up to 68% of basal-like breast cancer could be prevented by promoting breastfeeding and reducing abdominal adiposity...
- Will all Americans become overweight or obese? estimating the progression and cost of the US obesity epidemicYoufa Wang
Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
Obesity (Silver Spring) 16:2323-30. 2008..Timely, dramatic, and effective development and implementation of corrective programs/policies are needed to avoid the otherwise inevitable health and societal consequences implied by our projections ...
- The history of African gene flow into Southern Europeans, Levantines, and JewsPriya Moorjani
Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America
PLoS Genet 7:e1001373. 2011..For the Jewish admixture, we obtain an average estimated date of about 72 generations. This may reflect descent of these groups from a common ancestral population that already had some African ancestry prior to the Jewish Diasporas...
- Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemiaJohan Rung
McGill University and Genome Quebec Innovation Centre, Montreal, Canada
Nat Genet 41:1110-5. 2009....
- A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degenerationGregory S Hageman
Department of Ophthalmology and Visual Sciences, Cell Biology and Functional Genomics Laboratory, University of Iowa, Iowa City, IA 52240, USA
Proc Natl Acad Sci U S A 102:7227-32. 2005..We propose that genetic variation in a regulator of the alternative complement pathway, when combined with a triggering event, such as infection, underlie a major proportion of AMD in the human population...
- The archaeogenetics of EuropePedro Soares
Institute of Integrative and Comparative Biology, Faculty of Biological Sciences, University of Leeds, Leeds, UK
Curr Biol 20:R174-83. 2010....
- Interactions between genetic variants and breast cancer risk factors in the breast and prostate cancer cohort consortiumDaniele Campa
Genomic Epidemiology Group, German Cancer Research Center Deutsches Krebsforschungszentrum DKFZ, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
J Natl Cancer Inst 103:1252-63. 2011..Relatively little is known about the possible interactions between these loci and the established risk factors for breast cancer...
- The landscape of recombination in African AmericansAnjali G Hinch
Wellcome Trust Centre for Human Genetics, Oxford University, Roosevelt Drive, Oxford OX3 7BN, UK
Nature 476:170-5. 2011..Sites of this motif are predicted to be risk loci for disease-causing genomic rearrangements in individuals carrying these alleles. More generally, this map provides a resource for research in human genetic variation and evolution...
- FTO, type 2 diabetes, and weight gain throughout adult life: a meta-analysis of 41,504 subjects from the Scandinavian HUNT, MDC, and MPP studiesJens K Hertel
Department of Clinical Medicine, University of Bergen, Bergen, Norway
Diabetes 60:1637-44. 2011..FTO is the most important polygene identified for obesity. We aimed to investigate whether a variant in FTO affects type 2 diabetes risk entirely through its effect on BMI and how FTO influences BMI across adult life span...
- Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe ProjectGuillaume Lettre
Montreal Heart Institute, Montreal, Canada
PLoS Genet 7:e1001300. 2011..Our project has developed resources and methods that address both admixture- and SNP-association to maximize power for genetic discovery in even larger African-American consortia...
- Visceral adipose tissue accumulation differs according to ethnic background: results of the Multicultural Community Health Assessment Trial (M-CHAT)Scott A Lear
School of Kinesiology, Simon Fraser University, Vancouver, BC, Canada
Am J Clin Nutr 86:353-9. 2007..Previous studies have not adequately investigated differences in discrete regions of abdominal adiposity across ethnic groups...
- Runs of homozygosity in European populationsRuth McQuillan
Public Health Sciences, University of Edinburgh Medical School, Edinburgh EH8 9AG, UK
Am J Hum Genet 83:359-72. 2008....
- The reasons for geographic and racial differences in stroke study: objectives and designVirginia J Howard
Department of Epidemiology, University of Alabama at Birmingham, USA
Neuroepidemiology 25:135-43. 2005..Participants are followed via telephone at 6-month intervals for identification of stroke events. The novel aspects of the REGARDS study allow for the creation of a national cohort to address geographic and ethnic differences in stroke...
- The Caucasus as an asymmetric semipermeable barrier to ancient human migrationsBayazit Yunusbayev
Estonian Biocentre, Tartu, Estonia
Mol Biol Evol 29:359-65. 2012..Genetic discontinuity between the North Caucasus and the East European Plain contrasts with continuity through Anatolia and the Balkans, suggesting major routes of ancient gene flows and admixture...
- Genetic structure of Europeans: a view from the North-EastMari Nelis
Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia
PLoS ONE 4:e5472. 2009..Together with previously published data, our results allow the creation of a comprehensive European genetic map that will greatly facilitate inter-population genetic studies including genome wide association studies (GWAS)...
- State of disparities in cardiovascular health in the United StatesGeorge A Mensah
Office of the Director, Division of Adult and Community Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control, Mail Stop K 40, 4770 Buford Hwy NE, Atlanta, GA 30341 3717, USA
Circulation 111:1233-41. 2005..Having timely access to current data on disparities is important for policy and program development. Accordingly, we assessed the current magnitude of disparities in cardiovascular disease (CVD) and its risk factors in the United States...
- Genome-wide association study identifies eight loci associated with blood pressureChristopher Newton-Cheh
Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA
Nat Genet 41:666-76. 2009..These associations between common variants and blood pressure and hypertension offer mechanistic insights into the regulation of blood pressure and may point to novel targets for interventions to prevent cardiovascular disease...
- Population genetics models of local ancestrySimon Gravel
Genetics Department, Stanford University, Stanford, California 94305 5120, USA
Genetics 191:607-19. 2012..Considering HapMap African-American (ASW) data, we find that a model with two distinct phases of "European" gene flow significantly improves the modeling of both tract lengths and ancestry variances...
- Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathwaysNicole Soranzo
Human Genetics, Wellcome Trust Sanger Institute, Hinxton, U K
Diabetes 59:3229-39. 2010..We aimed to identify such genetic factors and investigate the extent to which they influence diabetes classification based on HbA₁(c) levels...
- Cumulative effects and predictive value of common obesity-susceptibility variants identified by genome-wide association studiesShengxu Li
MRC Epidemiology Unit, Institute of Metabolic Science, Cambridge, UK
Am J Clin Nutr 91:184-90. 2010..Large-scale genome-wide association studies have identified 12 genetic loci that are robustly associated with body mass index (BMI)...
- Ethnic differences in coronary calcification: the Multi-Ethnic Study of Atherosclerosis (MESA)Diane E Bild
Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, Bethesda, MD, USA
Circulation 111:1313-20. 2005....
- Estimation of individual admixture: analytical and study design considerationsHua Tang
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
Genet Epidemiol 28:289-301. 2005..g., simulations) not possible by Bayesian methods. Our simulation results demonstrate that inclusion of ancestral populations or their surrogates in the analysis is required by any method of IA estimation to obtain reasonable results...
- Evaluation of genetic markers as instruments for Mendelian randomization studies on vitamin DDiane J Berry
Centre for Paediatric Epidemiology and Biostatistics, UCL Institute of Child Health, London, United Kingdom
PLoS ONE 7:e37465. 2012....
- Adiposity, cardiometabolic risk, and vitamin D status: the Framingham Heart StudySusan Cheng
Framingham Heart Study, Framingham, Massachusetts, USA
Diabetes 59:242-8. 2010..Few studies relating vitamin D deficiency to obesity have included direct measures of adiposity. Furthermore, the degree to which vitamin D is associated with metabolic traits after adjusting for adiposity measures is unclear...
- A genome-wide association study in 19 633 Japanese subjects identified LHX3-QSOX2 and IGF1 as adult height lociYukinori Okada
Center for Genomic Medicine, Institute of Physical and Chemical Research, RIKEN, Kanagawa, Japan
Hum Mol Genet 19:2303-12. 2010..26 cm (95% confidence interval: 1.18-1.34) per 1.0 increase of the normalized Z score for height-increasing alleles, explaining 4.6% of the total variance of adult height...
- Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individualsZari Dastani
Department of Epidemiology, Biostatistics, and Occupational Health, Jewish General Hospital, Lady Davis Institute, McGill University, Montreal, Canada
PLoS Genet 8:e1002607. 2012..4Ã—10(-4), nâ€Š=â€Š121,335). These findings identify novel genetic determinants of adiponectin levels, which, taken together, influence risk of T2D and markers of insulin resistance...
- Inferring ancestral origin using a single multiplex assay of ancestry-informative marker SNPsC Phillips
Forensic Genetics Department, University of Santiago de Compostela, 15782, and Centro Nacional de Genotipado CeGen, Hospital Clinico Universitario, 15706 Galicia, Spain
Forensic Sci Int Genet 1:273-80. 2007..This study shows that by choosing SNPs exhibiting marked allele frequency differences between population-groups a practical forensic test for assigning the most likely ancestry can be achieved from a single multiplexed assay...
- An ancestry informative marker set for determining continental origin: validation and extension using human genome diversity panelsRami Nassir
Rowe Program in Human Genetics, Departments of Biochemistry and Medicine, University of California Davis, Davis, CA 95616, USA
BMC Genet 10:39. 2009..Previously, we described a panel of 128 SNP AIMs that were designed as a tool for ascertaining the origins of subjects from Europe, Sub-Saharan Africa, Americas, and East Asia...
- SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populationsHiroyuki Unoki
Laboratory for Endocrinology and Metabolism, Center for Genomic Medicine, RIKEN, Yokohama, Kanagawa 230 0045, Japan
Nat Genet 40:1098-102. 2008..5 x 10(-3); OR = 1.14, rs2237897, P = 2.4 x 10(-4); OR = 1.22) and Danish populations (additive model: rs2237895, P = 3.7 x 10(-11); OR = 1.24, rs2237897, P = 1.2 x 10(-4); OR = 1.36)...
- Skin pigmentation, biogeographical ancestry and admixture mappingMark D Shriver
Department of Anthropology, Penn State University, 409 Carpenter Bld, University Park, PA 16802, USA
Hum Genet 112:387-99. 2003..The implications and applications of ancestry estimates in biomedical research are discussed...
- Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitusKazuki Yasuda
Department of Metabolic Disorder, Research Institute, International Medical Center of Japan, Tokyo 162 8655, Japan
Nat Genet 40:1092-7. 2008..Our data thus implicate KCNQ1 as a diabetes susceptibility gene in groups of different ancestries...
- A predominantly neolithic origin for European paternal lineagesPatricia Balaresque
Department of Genetics, University of Leicester, Leicester, United Kingdom
PLoS Biol 8:e1000285. 2010....
- Differences in breast carcinoma characteristics in newly diagnosed African-American and Caucasian patients: a single-institution compilation compared with the National Cancer Institute's Surveillance, Epidemiology, and End Results databaseGloria J Morris
Department of Medical Oncology, Kimmel Cancer Center, Thomas Jefferson University Hospital, Philadelphia, PA 19107, USA
Cancer 110:876-84. 2007..Breast carcinomas in African-American patients appear to be more aggressive than in Caucasian patients due to multifactorial differences...
- Meta-analysis of genome-wide scans for human adult stature identifies novel Loci and associations with measures of skeletal frame sizeNicole Soranzo
Human Genetics Department, Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom
PLoS Genet 5:e1000445. 2009..Further statistical tests in larger numbers of individuals will be required to verify if the height loci affect height preferentially through these subcomponents of height...
- Fine mapping of five loci associated with low-density lipoprotein cholesterol detects variants that double the explained heritabilitySerena Sanna
Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche CNR, Monserrato, Italy
PLoS Genet 7:e1002198. 2011..Further, our results suggest that, as prelude to large-scale sequencing efforts, targeted re-sequencing efforts paired with large-scale genotyping will increase estimates of complex trait heritability explained by known loci...
- Abraham's children in the genome era: major Jewish diaspora populations comprise distinct genetic clusters with shared Middle Eastern AncestryGil Atzmon
Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Am J Hum Genet 86:850-9. 2010..Thus, this study demonstrates that European/Syrian and Middle Eastern Jews represent a series of geographical isolates or clusters woven together by shared IBD genetic threads...
- Identification of a new prostate cancer susceptibility locus on chromosome 8q24Meredith Yeager
Core Genotyping Facility, SAIC Frederick, Inc, NCI Frederick, Frederick, Maryland, USA
Nat Genet 41:1055-7. 2009..3 x 10(-10), heterozygote OR = 1.17, 95% CI 1.10-1.24; homozygote OR = 1.33, 95% CI 1.21-1.45). This defines a new locus associated with prostate cancer susceptibility on 8q24...
- Variants conferring risk of atrial fibrillation on chromosome 4q25Daniel F Gudbjartsson
deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
Nature 448:353-7. 2007..42 per copy. A stronger association was observed in individuals with typical atrial flutter. Both variants are adjacent to PITX2, which is known to have a critical function in left-right asymmetry of the heart...
- CUBN is a gene locus for albuminuriaCarsten A Böger
Department of Internal Medicine II, University Medical Center Regensburg, Regensburg, Germany
J Am Soc Nephrol 22:555-70. 2011..In summary, we identified a missense CUBN variant that associates with levels of albuminuria in both the general population and in individuals with diabetes...
- Incidence of atrial fibrillation in whites and African-Americans: the Atherosclerosis Risk in Communities (ARIC) studyAlvaro Alonso
Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, 1300 S 2nd Street, Minneapolis, MN 55454 USA
Am Heart J 158:111-7. 2009..To define the incidence and cumulative risk of atrial fibrillation (AF) in a population-based cohort of whites and African Americans...
- Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in womenCaroline S Fox
Framingham Heart Study, National Heart, Lung, and Blood Institute, National Institutes of Health, Framingham, Massachusetts, United States of America
PLoS Genet 8:e1002695. 2012..More refined phenotypes for body composition and fat distribution can detect new loci not previously uncovered in large-scale GWAS of anthropometric traits...
- Genetic variants at 2q24 are associated with susceptibility to type 2 diabetesLu Qi
Department of Nutrition, Harvard School of Public Health, and Brigham and Women s Hospital, Boston, MA, USA
Hum Mol Genet 19:2706-15. 2010..05). These data suggest that the 2q24 locus may influence the T2D risk by affecting glucose metabolism and insulin resistance...
- Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathwaysLisette Stolk
Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands
Nat Genet 44:260-8. 2012..Gene-set enrichment pathway analyses using the full GWAS data set identified exoDNase, NF-ÎºB signaling and mitochondrial dysfunction as biological processes related to timing of menopause...
- Three genome-wide association studies and a linkage analysis identify HERC2 as a human iris color geneManfred Kayser
Department of Forensic Molecular Biology, Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands
Am J Hum Genet 82:411-23. 2008..Testing markers in the HERC2-OCA2 region may be useful in forensic applications to predict eye color phenotypes of unknown persons of European genetic origin...
- Race and gender differences in C-reactive protein levelsAmit Khera
Donald W Reynolds Cardiovascular Clinical Research Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9047, USA
J Am Coll Cardiol 46:464-9. 2005..This study sought to determine whether there are race and gender differences in the distribution of C-reactive protein (CRP) levels...
- No significant association of 14 candidate genes with schizophrenia in a large European ancestry sample: implications for psychiatric geneticsAlan R Sanders
Department of Psychiatry and Behavioural Sciences, Evanston Northwestern Healthcare Research Institute, Evanston, IL 60201 3137, USA
Am J Psychiatry 165:497-506. 2008....
- Hypovitaminosis D prevalence and determinants among African American and white women of reproductive age: third National Health and Nutrition Examination Survey, 1988-1994Shanna Nesby-O'Dell
Division of Nutrition and Physical Activity, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta 30341 3717, USA
Am J Clin Nutr 76:187-92. 2002..African American women are at higher risk of vitamin D deficiency than are white women, but few studies have examined determinants of hypovitaminosis D in this population...
- Replication of genome-wide association studies (GWAS) loci for fasting plasma glucose in African-AmericansE Ramos
Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, 12 South Drive, MSC 5635, Bethesda, MD 20892, USA
Diabetologia 54:783-8. 2011..Thus, it is important to conduct replication analyses in populations with non-European ancestry to identify shared loci associated with FPG across populations...
- Gene copy-number variation and associated polymorphisms of complement component C4 in human systemic lupus erythematosus (SLE): low copy number is a risk factor for and high copy number is a protective factor against SLE susceptibility in European AmericaYan Yang
Center for Molecular and Human Genetics, Columbus Children s Research Institute, Columbus, OH 43205, USA
Am J Hum Genet 80:1037-54. 2007..This work demonstrates how gene CNV and its related polymorphisms are associated with the susceptibility to a human complex disease...
- Genetic and clinical predictors for breast cancer risk assessment and stratification among Chinese womenWei Zheng
Vanderbilt Epidemiology Center, Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, 2525 West End Avenue, Nashville, TN 37203 1738, USA
J Natl Cancer Inst 102:972-81. 2010..No risk assessment model that incorporates both genetic and clinical predictors is currently available to predict breast cancer risk in this population...
- A regional food-frequency questionnaire for the US Mississippi DeltaKatherine L Tucker
Jean Mayer US Department of Agriculture USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
Public Health Nutr 8:87-96. 2005....
- Genetic evidence for the convergent evolution of light skin in Europeans and East AsiansHeather L Norton
Department of Anthropology, The Pennsylvania State University, PA, USA
Mol Biol Evol 24:710-22. 2007..These findings support a case for the recent convergent evolution of a lighter pigmentation phenotype in Europeans and East Asians...
- HLA-A*3101 and carbamazepine-induced hypersensitivity reactions in EuropeansMark McCormack
Molecular and Cellular Therapeutics, The Royal College of Surgeons in Ireland, Dublin, Ireland
N Engl J Med 364:1134-43. 2011..The HLA-B*1502 allele has been shown to be strongly correlated with carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS-TEN) in the Han Chinese and other Asian populations but not in European populations...
- Genetic architecture of transcript-level variation in humansShiwei Duan
Section of Hematology Oncology, Department of Medicine, University of Chicago, Chicago, IL 60637, USA
Am J Hum Genet 82:1101-13. 2008..We highlight in the EPHX1 gene a deleterious nonsynonymous SNP that is distantly associated with gene expression of ORMDL3, a susceptibility gene for asthma...
- Genome-wide association and genetic functional studies identify autism susceptibility candidate 2 gene (AUTS2) in the regulation of alcohol consumptionGunter Schumann
Medical Research Council Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College, London SE5 8AF, United Kingdom
Proc Natl Acad Sci U S A 108:7119-24. 2011..001). Our finding of a regulator of alcohol consumption adds knowledge to our understanding of genetic mechanisms influencing alcohol drinking behavior...
- Impact of common variants of PPARG, KCNJ11, TCF7L2, SLC30A8, HHEX, CDKN2A, IGF2BP2, and CDKAL1 on the risk of type 2 diabetes in 5,164 IndiansGanesh Chauhan
Functional Genomics Unit, Institute of Genomics and Integrative Biology CSIR, Delhi, India
Diabetes 59:2068-74. 2010..We have studied the association of common variants in these eight genes with type 2 diabetes and related traits in Indians by combining the data from two independent case-control studies...
- A major Y-chromosome haplogroup R1b Holocene era founder effect in Central and Western EuropeNatalie M Myres
Sorenson Molecular Genealogy Foundation, Salt Lake City, UT, USA
Eur J Hum Genet 19:95-101. 2011....
- A genome-wide association study of serum uric acid in African AmericansBashira A Charles
Center for Research on Genomics and Global Health, National Human Genome Research Institute, Bethesda, MD 20892, USA
BMC Med Genomics 4:17. 2011....
- Acute effect of a single high-fat meal on forearm blood flow, blood pressure and heart rate in healthy male Asians and Caucasians: a pilot studyChumjit Bui
Department of Health Promotion and Education, School of Public Health, Loma Linda University, Loma Linda, CA, USA
Southeast Asian J Trop Med Public Health 41:490-500. 2010..These findings suggest that a single HF meal may contribute to the detrimental effects on vascular health in Asian males and raises speculation regarding the cumulative impact of a chronic HF diet in this population...
- Complete Khoisan and Bantu genomes from southern AfricaStephan C Schuster
Pennsylvania State University, Center for Comparative Genomics and Bioinformatics, 310 Wartik Lab, University Park, Pennsylvania 16802, USA
Nature 463:943-7. 2010..Adding the described variants to current databases will facilitate inclusion of southern Africans in medical research efforts, particularly when family and medical histories can be correlated with genome-wide data...
- Reproductive history and oral contraceptive use in relation to risk of triple-negative breast cancerAmanda I Phipps
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
J Natl Cancer Inst 103:470-7. 2011..Hormonally mediated risk factors may be differentially related to risk of triple-negative and ER+ breast cancers...
- Race and triple negative threats to breast cancer survival: a population-based study in Atlanta, GAMary Jo Lund
Department of Epidemiology, Rollins School of Public Health, Emory University, 1518 Clifton Road, NE, Atlanta, GA 30322, USA
Breast Cancer Res Treat 113:357-70. 2009..This study examines association of the ER/PR/HER2 subtypes with race and breast cancer survival...
- The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-AmericansNancy L Saccone
Department of Genetics, Washington University, St Louis, Missouri 63110, UA
Cancer Res 69:6848-56. 2009..The nonsynonymous SNP rs16969968, a known risk variant in populations of European-descent, is also significantly associated with risk in African-Americans. Additional SNPs contribute to risk in distinct ways in these two populations...
- Digital quantification of human eye color highlights genetic association of three new lociFan Liu
Department of Forensic Molecular Biology, Erasmus University Medical Center, Rotterdam, The Netherlands
PLoS Genet 6:e1000934. 2010..A model for predicting quantitative eye colors explained over 50% of trait variance in the Rotterdam Study. Over all our data exemplify that fine phenotyping is a useful strategy for finding genes involved in human complex traits...
- Genomic and geographic distribution of SNP-defined runs of homozygosity in EuropeansMichael Nothnagel
Institute of Medical Informatics and Statistics, Christian Albrechts University, 24105 Kiel, Germany
Hum Mol Genet 19:2927-35. 2010..As a consequence, the planning, design and interpretation of ROH-based genetic studies must take sample origin into account in order for such studies to be sensible and valid...
- Common variants in the trichohyalin gene are associated with straight hair in EuropeansSarah E Medland
Queensland Institute of Medical Research, Brisbane 4029, Australia
Am J Hum Genet 85:750-5. 2009..5x10(-31)). These variants are at their highest frequency in Northern Europeans, paralleling the distribution of the straight-hair EDAR variant in Asian populations...
- Breast cancer in African-American women: differences in tumor biology from European-American womenKandace Amend
Department of Oncological Sciences, Mount Sinai School of Medicine, New York, New York, USA
Cancer Res 66:8327-30. 2006..An overview of the current literature about racial differences in breast cancer prompts questions for future research to elucidate causes for the apparent disparities in tumor biology...
- Disrupted in schizophrenia 1 (DISC1): association with schizophrenia, schizoaffective disorder, and bipolar disorderColin A Hodgkinson
Section of Human Neurogenetics and Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, Rockville, MD, USA
Am J Hum Genet 75:862-72. 2004..These data support the idea that these apparently distinct disorders have at least a partially convergent etiology and that variation at the DISC1 locus predisposes individuals to a variety of psychiatric disorders...
- Color and genomic ancestry in BraziliansFlavia C Parra
Departamento de Bioquimica e Imunologia, Universidade Federal de Minas Gerais, 31270 901 Belo Horizonte, Brazil
Proc Natl Acad Sci U S A 100:177-82. 2003..Our data suggest that in Brazil, at an individual level, color, as determined by physical evaluation, is a poor predictor of genomic African ancestry, estimated by molecular markers...
- The relationship of ethnicity, socioeconomic factors, and overweight in US adolescentsPenny Gordon-Larsen
University of North Carolina, Department of Nutrition, School of Public Health, Chapel Hill, NC 27516 3997, USA
Obes Res 11:121-9. 2003..To examine the extent to which race/ethnic differences in income and education account for sex-specific disparities in overweight prevalence in white, African American, Hispanic, and Asian U.S. teens...
- Contextual analysis of breast and cervical cancer screening and factors associated with health care access among United States women, 2002Steven S Coughlin
Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
Soc Sci Med 66:260-75. 2008..A significant interaction was also observed between the percentage of county female population who were Hispanic and the percentage who were non-Hispanic Black...
- Identification of a systemic lupus erythematosus susceptibility locus at 11p13 between PDHX and CD44 in a multiethnic studyChristopher J Lessard
Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
Am J Hum Genet 88:83-91. 2011....
- A MicroRNA Approach to Screen for Sporadic Colon Cancer Exfoliately in Human StooFarid E Ahmed; Fiscal Year: 2010..However, larger well designed clinical studies are needed to corroborate initial results. ..
- Parathyroid Hormone & Vitamin D Effects on Salt Sensitivity and Vascular FunctionANNA LIZA BELEN VALINA TOTH; Fiscal Year: 2010....
- JACKSON HEART STUDYHERMAN ALFRED TAYLOR; Fiscal Year: 2009..abstract_text> ..
- JACKSON HEART STUDYAsoka Srinivasan; Fiscal Year: 2010..abstract_text> ..
- JACKSON HEART STUDYHERMAN ALFRED TAYLOR; Fiscal Year: 2009..abstract_text> ..
- JACKSON HEART STUDYASOKA S SRINIVASAN; Fiscal Year: 2011..abstract_text> ..
- JACKSON HEART STUDYHerman Taylor; Fiscal Year: 2010..abstract_text> ..
- JACKSON HEART STUDYASOKA S SRINIVASAN; Fiscal Year: 2013..abstract_text> ..
- Addressing Psychosocial Disparities in Rural Hispanic Cancer SurvivorsRachel M Ceballos; Fiscal Year: 2013..abstract_text> ..
- Improving Hmong Health through Community Based Participatory ResearchDIAN LORENE BAKER; Fiscal Year: 2013..The goal of this study is to assist in meeting the Healthy People 2020 objectives (D 2-14) for Hmong community members with Type 2 diabetes mellitus and improve health outcomes. ..
- Telomere and its bio-regulators as predictors for clinical diabetes in womenSimin Liu; Fiscal Year: 2010....
- Mediators of Atherosclerosis in South Asians Living in AmericaAlka M Kanaya; Fiscal Year: 2013..centers to identify risk factors linked to subclinical atherosclerosis and incident cardiovascular disease. These will provide targets for future therapies to prevent or cure the leading cause of death worldwide, cardiovascular disease. ..
- A dataset for the study of the social determinants of health.Peter A Muennig; Fiscal Year: 2010..This dataset will greatly advance scientific understanding of the social causation of disease and health disparities. ..
- Endogenous Cardiac Glycosides in AASKBrad C Astor; Fiscal Year: 2010..This information may help identify targets for treatment or prevention to reduce the high risk of cardiovascular disease in patients with chronic kidney disease. ..
- Ethnic/Racial Variation in Intracerebral Hemorrhage (ERICH)Daniel Woo; Fiscal Year: 2013..Yet we know little about the biologic differences that lead to this ethnic disparity. Our proposal will compare minorities with ICH to controls from the same population as well as explore genetic, radiographic and outcomes differences. ..
- Identification of Biomarkers for Early Detection of Renal Cell CarcinomaOthon Iliopoulos; Fiscal Year: 2012..In addition they may be used as surrogate markers for response to therapy and allow for early changes in biotherapy or targeted molecular therapy in case these latter ones do not work. ..
- Characterizing Mitochondrial DNA Susceptibility to Breast, Colorectal, and ProstaIona Cheng; Fiscal Year: 2012..In addition, we will evaluate heterogeneity of effects by disease sub-groups, environmental factors and known genetic risk factors. ..
- Randomized Trial of a Postpartum Diabetes Prevention Program for Hispanic WomenLisa Chasan-Taber; Fiscal Year: 2013..Measures of adherence will include accelerometers and dietary recalls. ..
- Pilot Study of Arsenic, UV and Melanoma in a Non-Hispanic White PopulationJanice W Yager; Fiscal Year: 2011....
- Effects of Vitamin D and Marine Omega-3 Fatty Acids on Anemia in the ElderlyNancy Berliner; Fiscal Year: 2013..abstract_text> ..
- CARDIA Echocardiography Reading CenterJoao A C Lima; Fiscal Year: 2012..abstract_text> ..
- CARDIA ECHO RC CAN 9-8470189Joao Lima; Fiscal Year: 2009..abstract_text> ..
- CARDIASharina D Person; Fiscal Year: 2010..abstract_text> ..
- Coronary Artery Risk Development in Young Adults (CARDIA) Study - CCJames Shikany; Fiscal Year: 2012..abstract_text> ..
- CARDIA ECHO RC Joao A C Lima; Fiscal Year: 2011..abstract_text> ..
- CARDIAO Dale Williams; Fiscal Year: 2011..abstract_text> ..
- Using Mixed Reality to build peer resistance skills in Latina middle schoolersANNE E contact NORRIS; Fiscal Year: 2010..Study results will also be helpful to other researchers developing technology based health games designed to promote health. ..
- CARDIA ECHO RC Joao Lima; Fiscal Year: 2010..abstract_text> ..
- Chinese American Eye StudyRohit Varma; Fiscal Year: 2013..These findings are also likely to be of increasing public health importance, as the societal burden of age-related eye disease will likely increase with the aging of this rapidly growing segment of the US population. ..
- RCT of Stress Reduction in the Secondary Prevention of CHD in African AmericansRobert Schneider; Fiscal Year: 2010....
- STROKE INCIDENCE AND RISK FACTORS IN A TRI-ETHNIC REGIONRalph L Sacco; Fiscal Year: 2013..We need to understand the importance of these conditions in predicting stroke, MI, vascular death, and determining cognitive decline among minority populations. ..
- Genome Wide Admixture Scan for Multiple Myeloma in African AmericansCHRISTOPHER ALAN HAIMAN; Fiscal Year: 2013..Our ultimate goal is to reduce the health disparity experienced by African Americans due to this fatal cancer. ..
- Hampton University Skin of Color Research Institute Skin of Color Symposium 2011:Meena Katdare; Fiscal Year: 2011....
- Perfluoroalkyl chemicals and the risk of developing clinical and subclinical CVDAnoop Shankar; Fiscal Year: 2012..We will study the association between blood PFCs and cardiovascular disease. If we find an association, it indirectly suggests that reducing PFCs may have a role in preventing these diseases. ..
- Epidemiologic Study of Sick Sinus SyndromeAlvaro Alonso; Fiscal Year: 2012....
- Coronary Artery Risk Development in Young Adults (CARDIA) Study - Field CenterKIANG J LIU; Fiscal Year: 2013..abstract_text> ..
- Coronary Artery Risk Development in Young Adults (CARDIA) Study - Field CenterKIANG J LIU; Fiscal Year: 2012..abstract_text> ..
- CARDIAKIANG J LIU; Fiscal Year: 2009..abstract_text> ..
- CARDIAKIANG J LIU; Fiscal Year: 2011..abstract_text> ..
- CARDIAKIANG J LIU; Fiscal Year: 2010..abstract_text> ..
- Melanoma Prevention: Using the SunMarianne Berwick; Fiscal Year: 2013..The NCI clearly states that prevention must be based on knowledge developed by integrative population science teams working in the population and in the laboratory. ..
- Coronary Artery Risk Development in Young Adults (CARDIA) - Field CenterCora E Lewis; Fiscal Year: 2013..abstract_text> ..
- Coronary Artery Risk Development in Young Adults (CARDIA) Study - Field CenterStephen Sidney; Fiscal Year: 2013..abstract_text> ..
- The Johnston County OA Project: Arthritis and DisabilityJoanne M Jordan; Fiscal Year: 2013..By examining these factors in multiple aspects of the OA process in both ethnic groups within one study, efficiency and significant impact upon the public health can be maximized. ..
- Coronary Artery Risk Development in Young Adults (CARDIA) Study - Field CenterPamela Schreiner; Fiscal Year: 2012..abstract_text> ..
- Coronary Artery Risk Development in Young Adults (CARDIA) Study - Field CenterStephen Sidney; Fiscal Year: 2012..abstract_text> ..
- Coronary Artery Risk Development in Young Adults (CARDIA) - Field CenterCora E Lewis; Fiscal Year: 2012..abstract_text> ..
- CARDIACora E Lewis; Fiscal Year: 2011..abstract_text> ..
- CARDIAPamela J Schreiner; Fiscal Year: 2010..abstract_text> ..
- CARDIASharina Person; Fiscal Year: 2009..abstract_text> ..
- CARDIACora E Lewis; Fiscal Year: 2009..abstract_text> ..
- CARDIAStephen Sidney; Fiscal Year: 2011..abstract_text> ..
- CARDIAPamela Schreiner; Fiscal Year: 2011..abstract_text> ..
- CARDIACora E Lewis; Fiscal Year: 2010..abstract_text> ..
- CARDIAPamela J Schreiner; Fiscal Year: 2009..abstract_text> ..
- CARDIAStephen Sidney; Fiscal Year: 2009..abstract_text> ..
- CARDIAStephen Sidney; Fiscal Year: 2010..abstract_text> ..
- Gene Networks for Prostate Cancer ProgressionLeif Peterson; Fiscal Year: 2005..Characterization of the FGFR1 and FGFR2 pathways in prostate cancer will contribute to the molecular understanding and early detection of patients that may experience rapid progression of metastases. ..
- Race, Ethnicity, Nativity and Housing Outcomes in Los AngelesEILEEN DIAZ MCCONNELL; Fiscal Year: 2010....
- Sources of Change and Stability in Low-Income Black MarriagesBENJAMIN REUVEN KARNEY; Fiscal Year: 2010..These data will be combined with data from an ongoing study of low-income Hispanic newlyweds in order to identify the sources of differences in marital outcomes for these two similarly underprivileged groups ..
- UNIVERSITY OF NEW MEXICO CANCER CENTER PLANNING GRANTCheryl Willman; Fiscal Year: 2004..abstract_text> ..
- HCV TREATMENT IN AFRICAN AMERICANS VS NON HISPANIC WHIT*Lennox Jeffers; Fiscal Year: 2005..SPECIFIC AIM 7. To identify sociodemographic (e.g., age, education income, gender, ethnicity) and psychosocial (e.g., anxiety, depression, coping) predictors of adherence to treatment and virologic response to HCV RNA. ..
- RACE AND ETHNIC DIFFERENCES IN U.S. BIRTH OUTCOMESMichael Grossman; Fiscal Year: 1990..Can the upward trend in the percentage of illegitimate births explain the modest decline in the percentage of light births in the face of a rapid increase over time in the prompt initiation of prenatal care, especially among minorities?..
- GENETICS OF BLOOD PRESSURE CONTROL IN MEXICAN AMERICANSLarry Atwood; Fiscal Year: 2000..Finally, all loci that have detectable effects on the intermediate phenotypes will be tested for their effects on blood pressure. ..
- VIRAHEP-C Clinical CenterAnna Lok; Fiscal Year: 2005..abstract_text> ..
- Dose-dependent anti-inflammatory effects of vitamin D in a human gingivitis modelRaul Garcia; Fiscal Year: 2009....
- Intensive Outpatient v. Outpatient Treatment with Buprenorphine among African AmeShannon Gwin Mitchell; Fiscal Year: 2010....
- Racial & Ethnic Disparities in Incidence and Inpatient Outcomes of Acute StrokeAmresh D Hanchate; Fiscal Year: 2010..For effective targeting of interventions and public policy, our study aims to use evidence to identify and prioritize modifiable factors appropriate for each minority cohort. ..
- Disparities in CHD in the Jackson Heart StudyMario Sims; Fiscal Year: 2010..This research will also show which factors health policy makers need to focus on in order to address and eliminate CHD disparities. ..
- Resistance to Antiviral Therapy in Chronic Hepatitis CNorah Terrault; Fiscal Year: 2005..Moreover, the methodologies developed for patient outreach within the context of this collaborative study will serve as a model for enhancing participation of African Americans in clinical research. ..
- INCIDENCE OF DIABETES AND CVD IN MEXICAN AMERICANSMichael Stern; Fiscal Year: 2002..The investigators note that this will aid in the interpretation of data relating to possible ethnic differences in cause-specific mortality based on death certificate coding. ..
- Using Doctor-Patient Teams to Reduce Health DisparitiesLouis Penner; Fiscal Year: 2007..If successful, the study should provide an exportable means of improving communication between physicians and minority group patients and reducing disparities in health care. [unreadable] [unreadable] [unreadable]..
- Racial/Ethnic Disparities and High Volume HospitalsBradford Gray; Fiscal Year: 2003..S. Methodologically, we will explore a number of measurement issues, including the effects of alternative ways of operationalizing high volume and proximity. ..