european continental ancestry group

Summary

Summary: Individuals whose ancestral origins are in the continent of Europe.

Top Publications

  1. pmc Biological, clinical and population relevance of 95 loci for blood lipids
    Tanya M Teslovich
    Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA
    Nature 466:707-13. 2010
  2. pmc Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
    Elizabeth K Speliotes
    Metabolism Initiative and Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA
    Nat Genet 42:937-48. 2010
  3. pmc Evolution and functional impact of rare coding variation from deep sequencing of human exomes
    Jacob A Tennessen
    Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA
    Science 337:64-9. 2012
  4. pmc An abundance of rare functional variants in 202 drug target genes sequenced in 14,002 people
    Matthew R Nelson
    Department of Quantitative Sciences, GlaxoSmithKline GSK, Research Triangle Park, NC 27709, USA
    Science 337:100-4. 2012
  5. pmc Transcriptome genetics using second generation sequencing in a Caucasian population
    Stephen B Montgomery
    Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, 1211 Switzerland
    Nature 464:773-7. 2010
  6. pmc Recent explosive human population growth has resulted in an excess of rare genetic variants
    Alon Keinan
    Department of Biological Statistics and Computational Biology, Cornell University, Ithaca, NY 14853, USA
    Science 336:740-3. 2012
  7. pmc Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts
    Yurii S Aulchenko
    1 Department of Epidemiology and Biostatistics, Erasmus University Medical Center, P O Box 2040, 3000 CA Rotterdam, The Netherlands 2 These authors contributed equally to this work
    Nat Genet 41:47-55. 2009
  8. ncbi Sequence variations in PCSK9, low LDL, and protection against coronary heart disease
    Jonathan C Cohen
    Donald W Reynolds Cardiovascular Clinical Research Center, University of Texas Southwestern Medical Center, Dallas, TX 75390 9046, USA
    N Engl J Med 354:1264-72. 2006
  9. pmc The contextual effect of the local food environment on residents' diets: the atherosclerosis risk in communities study
    Kimberly Morland
    Department of Epidemiology, University of North Carolina, Chapel Hill, USA
    Am J Public Health 92:1761-7. 2002
  10. ncbi Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey
    Earl S Ford
    Centers for Disease Control and Prevention, 1600 Clifton Rd NE, Mailstop E 17, Atlanta, GA 30333
    JAMA 287:356-9. 2002

Research Grants

  1. A MicroRNA Approach to Screen for Sporadic Colon Cancer Exfoliately in Human Stoo
    Farid E Ahmed; Fiscal Year: 2010
  2. Parathyroid Hormone & Vitamin D Effects on Salt Sensitivity and Vascular Function
    ANNA LIZA BELEN VALINA TOTH; Fiscal Year: 2010
  3. JACKSON HEART STUDY
    HERMAN ALFRED TAYLOR; Fiscal Year: 2009
  4. JACKSON HEART STUDY
    Asoka Srinivasan; Fiscal Year: 2010
  5. JACKSON HEART STUDY
    HERMAN ALFRED TAYLOR; Fiscal Year: 2009
  6. JACKSON HEART STUDY
    ASOKA S SRINIVASAN; Fiscal Year: 2011
  7. JACKSON HEART STUDY
    Herman Taylor; Fiscal Year: 2010
  8. JACKSON HEART STUDY
    ASOKA S SRINIVASAN; Fiscal Year: 2013
  9. Addressing Psychosocial Disparities in Rural Hispanic Cancer Survivors
    Rachel M Ceballos; Fiscal Year: 2013
  10. Improving Hmong Health through Community Based Participatory Research
    DIAN LORENE BAKER; Fiscal Year: 2013

Detail Information

Publications318 found, 100 shown here

  1. pmc Biological, clinical and population relevance of 95 loci for blood lipids
    Tanya M Teslovich
    Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA
    Nature 466:707-13. 2010
    ..Taken together, our findings provide the foundation to develop a broader biological understanding of lipoprotein metabolism and to identify new therapeutic opportunities for the prevention of CAD...
  2. pmc Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
    Elizabeth K Speliotes
    Metabolism Initiative and Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA
    Nat Genet 42:937-48. 2010
    ..Furthermore, genes in other newly associated loci may provide new insights into human body weight regulation...
  3. pmc Evolution and functional impact of rare coding variation from deep sequencing of human exomes
    Jacob A Tennessen
    Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA
    Science 337:64-9. 2012
    ..Furthermore, we show that large sample sizes will be required to associate rare variants with complex traits...
  4. pmc An abundance of rare functional variants in 202 drug target genes sequenced in 14,002 people
    Matthew R Nelson
    Department of Quantitative Sciences, GlaxoSmithKline GSK, Research Triangle Park, NC 27709, USA
    Science 337:100-4. 2012
    ..We conclude that because of rapid population growth and weak purifying selection, human populations harbor an abundance of rare variants, many of which are deleterious and have relevance to understanding disease risk...
  5. pmc Transcriptome genetics using second generation sequencing in a Caucasian population
    Stephen B Montgomery
    Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, 1211 Switzerland
    Nature 464:773-7. 2010
    ..This analysis shows that high throughput sequencing technologies reveal new properties of genetic effects on the transcriptome and allow the exploration of genetic effects in cellular processes...
  6. pmc Recent explosive human population growth has resulted in an excess of rare genetic variants
    Alon Keinan
    Department of Biological Statistics and Computational Biology, Cornell University, Ithaca, NY 14853, USA
    Science 336:740-3. 2012
    ..Hence, the extreme recent human population growth needs to be taken into consideration in studying the genetics of complex diseases and traits...
  7. pmc Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts
    Yurii S Aulchenko
    1 Department of Epidemiology and Biostatistics, Erasmus University Medical Center, P O Box 2040, 3000 CA Rotterdam, The Netherlands 2 These authors contributed equally to this work
    Nat Genet 41:47-55. 2009
    ..001) and coronary heart disease incidence (P = 0.04). The genetic risk score improves the screening of high-risk groups of dyslipidemia over classical risk factors...
  8. ncbi Sequence variations in PCSK9, low LDL, and protection against coronary heart disease
    Jonathan C Cohen
    Donald W Reynolds Cardiovascular Clinical Research Center, University of Texas Southwestern Medical Center, Dallas, TX 75390 9046, USA
    N Engl J Med 354:1264-72. 2006
    ..We examined the effect of DNA-sequence variations that reduce plasma levels of LDL cholesterol on the incidence of coronary events in a large population...
  9. pmc The contextual effect of the local food environment on residents' diets: the atherosclerosis risk in communities study
    Kimberly Morland
    Department of Epidemiology, University of North Carolina, Chapel Hill, USA
    Am J Public Health 92:1761-7. 2002
    ..We studied the association between the local food environment and residents' report of recommended dietary intake...
  10. ncbi Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey
    Earl S Ford
    Centers for Disease Control and Prevention, 1600 Clifton Rd NE, Mailstop E 17, Atlanta, GA 30333
    JAMA 287:356-9. 2002
    ..Limited information is available about the prevalence of the metabolic syndrome in the United States, however...
  11. pmc The metabolic syndrome: prevalence and associated risk factor findings in the US population from the Third National Health and Nutrition Examination Survey, 1988-1994
    Yong Woo Park
    Department of Family Medicine, Sungkyunkwan University School of Medicine, Seoul, Korea
    Arch Intern Med 163:427-36. 2003
    ..The extent to which the metabolic syndrome is associated with demographic and potentially modifiable lifestyle factors in the US population is unknown...
  12. doi A draft sequence of the Neandertal genome
    Richard E Green
    Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, D 04103 Leipzig, Germany
    Science 328:710-22. 2010
    ....
  13. pmc Ancestry informative marker sets for determining continental origin and admixture proportions in common populations in America
    Roman Kosoy
    Rowe Program in Human Genetics, Department of Biochemistry, University of California Davis, Davis, California 95616, USA
    Hum Mutat 30:69-78. 2009
    ..We conclude that investigators can use TaqMan assays for the selected AIMs as a simple and cost efficient tool to control for differences in continental ancestry when conducting association studies in ethnically diverse populations...
  14. pmc Assessing the evolutionary impact of amino acid mutations in the human genome
    Adam R Boyko
    Department of Biological Statistics and Computational Biology, Cornell University, Ithaca, New York, USA
    PLoS Genet 4:e1000083. 2008
    ....
  15. pmc Mitochondrial DNA signals of late glacial recolonization of Europe from near eastern refugia
    Maria Pala
    School of Applied Sciences, University of Huddersfield, Queensgate, Huddersfield, UK
    Am J Hum Genet 90:915-24. 2012
    ....
  16. pmc Genetic variants influencing circulating lipid levels and risk of coronary artery disease
    Dawn M Waterworth
    Genetics Division, GlaxoSmithKline R and D, King of Prussia, PA, USA
    Arterioscler Thromb Vasc Biol 30:2264-76. 2010
    ..We therefore conducted a genome-wide association study to identify novel genetic determinants of low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglycerides...
  17. pmc Type 2 diabetes risk alleles demonstrate extreme directional differentiation among human populations, compared to other diseases
    Rong Chen
    Division of Systems Medicine, Department of Pediatrics, Stanford University School of Medicine, Stanford, California, United States of America
    PLoS Genet 8:e1002621. 2012
    ..Our results indicate that the differential frequencies of T2D risk alleles may contribute to the observed disparity in T2D incidence rates across ethnic populations...
  18. doi Novel breast cancer susceptibility locus at 9q31.2: results of a genome-wide association study
    Olivia Fletcher
    Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK
    J Natl Cancer Inst 103:425-35. 2011
    ..Genome-wide association studies have identified several common genetic variants associated with breast cancer risk. It is likely, however, that a substantial proportion of such loci have not yet been discovered...
  19. pmc The landscape of recombination in African Americans
    Anjali G Hinch
    Wellcome Trust Centre for Human Genetics, Oxford University, Roosevelt Drive, Oxford OX3 7BN, UK
    Nature 476:170-5. 2011
    ..Sites of this motif are predicted to be risk loci for disease-causing genomic rearrangements in individuals carrying these alleles. More generally, this map provides a resource for research in human genetic variation and evolution...
  20. pmc High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis
    Steve Eyre
    Arthritis Research UK Epidemiology Unit, Centre for Musculoskeletal Research, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK
    Nat Genet 44:1336-40. 2012
    ..Bioinformatic analyses generated strong hypotheses for the causal SNP at seven loci. This study illustrates the advantages of dense SNP mapping analysis to inform subsequent functional investigations...
  21. doi Genetic discontinuity between local hunter-gatherers and central Europe's first farmers
    B Bramanti
    Institute for Anthropology, University of Mainz, Mainz, Germany
    Science 326:137-40. 2009
    ..Together, these analyses provide persuasive evidence that the first farmers were not the descendants of local hunter-gatherers but immigrated into central Europe at the onset of the Neolithic...
  22. pmc Epidemiology of basal-like breast cancer
    Robert C Millikan
    Department of Epidemiology, CB 7435, School of Public Health, University of North Carolina, Chapel Hill, NC 27599 7435, USA
    Breast Cancer Res Treat 109:123-39. 2008
    ..Among younger African-American women, we estimate that up to 68% of basal-like breast cancer could be prevented by promoting breastfeeding and reducing abdominal adiposity...
  23. pmc Multifactor-dimensionality reduction reveals high-order interactions among estrogen-metabolism genes in sporadic breast cancer
    M D Ritchie
    Program in Human Genetics, Department of Molecular Physiology and Biophysics, Vanderbilt University Medical School, Nashville, TN 37232, USA
    Am J Hum Genet 69:138-47. 2001
    ..To our knowledge, this is the first report of a four-locus interaction associated with a common complex multifactorial disease...
  24. doi Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia
    Johan Rung
    McGill University and Genome Quebec Innovation Centre, Montreal, Canada
    Nat Genet 41:1110-5. 2009
    ....
  25. pmc Interactions between genetic variants and breast cancer risk factors in the breast and prostate cancer cohort consortium
    Daniele Campa
    Genomic Epidemiology Group, German Cancer Research Center Deutsches Krebsforschungszentrum DKFZ, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    J Natl Cancer Inst 103:1252-63. 2011
    ..Relatively little is known about the possible interactions between these loci and the established risk factors for breast cancer...
  26. doi The archaeogenetics of Europe
    Pedro Soares
    Institute of Integrative and Comparative Biology, Faculty of Biological Sciences, University of Leeds, Leeds, UK
    Curr Biol 20:R174-83. 2010
    ....
  27. pmc FTO, type 2 diabetes, and weight gain throughout adult life: a meta-analysis of 41,504 subjects from the Scandinavian HUNT, MDC, and MPP studies
    Jens K Hertel
    Department of Clinical Medicine, University of Bergen, Bergen, Norway
    Diabetes 60:1637-44. 2011
    ..FTO is the most important polygene identified for obesity. We aimed to investigate whether a variant in FTO affects type 2 diabetes risk entirely through its effect on BMI and how FTO influences BMI across adult life span...
  28. pmc Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project
    Guillaume Lettre
    Montreal Heart Institute, Montreal, Canada
    PLoS Genet 7:e1001300. 2011
    ..Our project has developed resources and methods that address both admixture- and SNP-association to maximize power for genetic discovery in even larger African-American consortia...
  29. pmc Runs of homozygosity in European populations
    Ruth McQuillan
    Public Health Sciences, University of Edinburgh Medical School, Edinburgh EH8 9AG, UK
    Am J Hum Genet 83:359-72. 2008
    ....
  30. ncbi Waist circumference percentiles in nationally representative samples of African-American, European-American, and Mexican-American children and adolescents
    Jose R Fernandez
    Section on Statistical Genetics, Department of Biostatistics, Clinical Nutrition Research Center, University of Alabama at Birmingham, 35294 3360, USA
    J Pediatr 145:439-44. 2004
    ..To describe and provide estimates of the distribution of waist circumference (WC) according to percentiles in African-, European-, and Mexican-American children, and to test for group differences at different percentiles...
  31. pmc Genetic structure of Europeans: a view from the North-East
    Mari Nelis
    Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia
    PLoS ONE 4:e5472. 2009
    ..Together with previously published data, our results allow the creation of a comprehensive European genetic map that will greatly facilitate inter-population genetic studies including genome wide association studies (GWAS)...
  32. doi The Caucasus as an asymmetric semipermeable barrier to ancient human migrations
    Bayazit Yunusbayev
    Estonian Biocentre, Tartu, Estonia
    Mol Biol Evol 29:359-65. 2012
    ..Genetic discontinuity between the North Caucasus and the East European Plain contrasts with continuity through Anatolia and the Balkans, suggesting major routes of ancient gene flows and admixture...
  33. pmc Genome-wide association study identifies eight loci associated with blood pressure
    Christopher Newton-Cheh
    Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA
    Nat Genet 41:666-76. 2009
    ..These associations between common variants and blood pressure and hypertension offer mechanistic insights into the regulation of blood pressure and may point to novel targets for interventions to prevent cardiovascular disease...
  34. pmc Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci
    Folkert W Asselbergs
    Department of Cardiology, Division of Heart and Lungs, University Medical Center Utrecht, Utrecht, The Netherlands
    Am J Hum Genet 91:823-38. 2012
    ..The explained phenotypic variance from this approach was comparable to that from a meta-analysis of GWAS data, suggesting that a focused genotyping approach can further increase the understanding of heritability of plasma lipids...
  35. pmc Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways
    Nicole Soranzo
    Human Genetics, Wellcome Trust Sanger Institute, Hinxton, U K
    Diabetes 59:3229-39. 2010
    ..We aimed to identify such genetic factors and investigate the extent to which they influence diabetes classification based on HbA₁(c) levels...
  36. doi Cumulative effects and predictive value of common obesity-susceptibility variants identified by genome-wide association studies
    Shengxu Li
    MRC Epidemiology Unit, Institute of Metabolic Science, Cambridge, UK
    Am J Clin Nutr 91:184-90. 2010
    ..Large-scale genome-wide association studies have identified 12 genetic loci that are robustly associated with body mass index (BMI)...
  37. pmc Incidence of atrial fibrillation in whites and African-Americans: the Atherosclerosis Risk in Communities (ARIC) study
    Alvaro Alonso
    Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, 1300 S 2nd Street, Minneapolis, MN 55454 USA
    Am Heart J 158:111-7. 2009
    ..To define the incidence and cumulative risk of atrial fibrillation (AF) in a population-based cohort of whites and African Americans...
  38. pmc Evaluation of genetic markers as instruments for Mendelian randomization studies on vitamin D
    Diane J Berry
    Centre for Paediatric Epidemiology and Biostatistics, UCL Institute of Child Health, London, United Kingdom
    PLoS ONE 7:e37465. 2012
    ....
  39. pmc Adiposity, cardiometabolic risk, and vitamin D status: the Framingham Heart Study
    Susan Cheng
    Framingham Heart Study, Framingham, Massachusetts, USA
    Diabetes 59:242-8. 2010
    ..Few studies relating vitamin D deficiency to obesity have included direct measures of adiposity. Furthermore, the degree to which vitamin D is associated with metabolic traits after adjusting for adiposity measures is unclear...
  40. ncbi Estimation of individual admixture: analytical and study design considerations
    Hua Tang
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Genet Epidemiol 28:289-301. 2005
    ..g., simulations) not possible by Bayesian methods. Our simulation results demonstrate that inclusion of ancestral populations or their surrogates in the analysis is required by any method of IA estimation to obtain reasonable results...
  41. pmc Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals
    Zari Dastani
    Department of Epidemiology, Biostatistics, and Occupational Health, Jewish General Hospital, Lady Davis Institute, McGill University, Montreal, Canada
    PLoS Genet 8:e1002607. 2012
    ..4×10(-4), n = 121,335). These findings identify novel genetic determinants of adiponectin levels, which, taken together, influence risk of T2D and markers of insulin resistance...
  42. doi Inferring ancestral origin using a single multiplex assay of ancestry-informative marker SNPs
    C Phillips
    Forensic Genetics Department, University of Santiago de Compostela, 15782, and Centro Nacional de Genotipado CeGen, Hospital Clinico Universitario, 15706 Galicia, Spain
    Forensic Sci Int Genet 1:273-80. 2007
    ..This study shows that by choosing SNPs exhibiting marked allele frequency differences between population-groups a practical forensic test for assigning the most likely ancestry can be achieved from a single multiplexed assay...
  43. doi A genome-wide association study in 19 633 Japanese subjects identified LHX3-QSOX2 and IGF1 as adult height loci
    Yukinori Okada
    Center for Genomic Medicine, Institute of Physical and Chemical Research, RIKEN, Kanagawa, Japan
    Hum Mol Genet 19:2303-12. 2010
    ..26 cm (95% confidence interval: 1.18-1.34) per 1.0 increase of the normalized Z score for height-increasing alleles, explaining 4.6% of the total variance of adult height...
  44. pmc An ancestry informative marker set for determining continental origin: validation and extension using human genome diversity panels
    Rami Nassir
    Rowe Program in Human Genetics, Departments of Biochemistry and Medicine, University of California Davis, Davis, CA 95616, USA
    BMC Genet 10:39. 2009
    ..Previously, we described a panel of 128 SNP AIMs that were designed as a tool for ascertaining the origins of subjects from Europe, Sub-Saharan Africa, Americas, and East Asia...
  45. doi Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus
    Kazuki Yasuda
    Department of Metabolic Disorder, Research Institute, International Medical Center of Japan, Tokyo 162 8655, Japan
    Nat Genet 40:1092-7. 2008
    ..Our data thus implicate KCNQ1 as a diabetes susceptibility gene in groups of different ancestries...
  46. ncbi Differences in breast carcinoma characteristics in newly diagnosed African-American and Caucasian patients: a single-institution compilation compared with the National Cancer Institute's Surveillance, Epidemiology, and End Results database
    Gloria J Morris
    Department of Medical Oncology, Kimmel Cancer Center, Thomas Jefferson University Hospital, Philadelphia, PA 19107, USA
    Cancer 110:876-84. 2007
    ..Breast carcinomas in African-American patients appear to be more aggressive than in Caucasian patients due to multifactorial differences...
  47. pmc A predominantly neolithic origin for European paternal lineages
    Patricia Balaresque
    Department of Genetics, University of Leicester, Leicester, United Kingdom
    PLoS Biol 8:e1000285. 2010
    ....
  48. doi Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease
    Jean Charles Lambert
    INSERM U744, Lille, France
    Nat Genet 41:1094-9. 2009
    ..Previous biological studies support roles of CLU and CR1 in the clearance of beta amyloid (Abeta) peptide, the principal constituent of amyloid plaques, which are one of the major brain lesions of individuals with Alzheimer's disease...
  49. ncbi SLC24A5, a putative cation exchanger, affects pigmentation in zebrafish and humans
    Rebecca L Lamason
    Jake Gittlen Cancer Research Foundation, Department of Pathology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Science 310:1782-6. 2005
    ....
  50. doi Tumor immunobiological differences in prostate cancer between African-American and European-American men
    Tiffany A Wallace
    Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892 4258, USA
    Cancer Res 68:927-36. 2008
    ..The profiles portray the existence of a distinct tumor microenvironment in these two patient groups...
  51. pmc Fine mapping of five loci associated with low-density lipoprotein cholesterol detects variants that double the explained heritability
    Serena Sanna
    Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche CNR, Monserrato, Italy
    PLoS Genet 7:e1002198. 2011
    ..Further, our results suggest that, as prelude to large-scale sequencing efforts, targeted re-sequencing efforts paired with large-scale genotyping will increase estimates of complex trait heritability explained by known loci...
  52. pmc Meta-analysis of genome-wide scans for human adult stature identifies novel Loci and associations with measures of skeletal frame size
    Nicole Soranzo
    Human Genetics Department, Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom
    PLoS Genet 5:e1000445. 2009
    ..Further statistical tests in larger numbers of individuals will be required to verify if the height loci affect height preferentially through these subcomponents of height...
  53. pmc Abraham's children in the genome era: major Jewish diaspora populations comprise distinct genetic clusters with shared Middle Eastern Ancestry
    Gil Atzmon
    Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Am J Hum Genet 86:850-9. 2010
    ..Thus, this study demonstrates that European/Syrian and Middle Eastern Jews represent a series of geographical isolates or clusters woven together by shared IBD genetic threads...
  54. pmc Identification of a new prostate cancer susceptibility locus on chromosome 8q24
    Meredith Yeager
    Core Genotyping Facility, SAIC Frederick, Inc, NCI Frederick, Frederick, Maryland, USA
    Nat Genet 41:1055-7. 2009
    ..3 x 10(-10), heterozygote OR = 1.17, 95% CI 1.10-1.24; homozygote OR = 1.33, 95% CI 1.21-1.45). This defines a new locus associated with prostate cancer susceptibility on 8q24...
  55. pmc CUBN is a gene locus for albuminuria
    Carsten A Böger
    Department of Internal Medicine II, University Medical Center Regensburg, Regensburg, Germany
    J Am Soc Nephrol 22:555-70. 2011
    ..In summary, we identified a missense CUBN variant that associates with levels of albuminuria in both the general population and in individuals with diabetes...
  56. ncbi Variants conferring risk of atrial fibrillation on chromosome 4q25
    Daniel F Gudbjartsson
    deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
    Nature 448:353-7. 2007
    ..42 per copy. A stronger association was observed in individuals with typical atrial flutter. Both variants are adjacent to PITX2, which is known to have a critical function in left-right asymmetry of the heart...
  57. pmc Genome-wide association study of circulating vitamin D levels
    Jiyoung Ahn
    Department of Environmental Medicine, New York University School of Medicine, New York, NY 10016, USA
    Hum Mol Genet 19:2739-45. 2010
    ..8x10(-49)), NADSYN1/DHCR7 (P=3.4x10(-9)) and CYP2R1 (P=2.9x10(-17)), but not C10orf88 (P=2.4x10(-5))...
  58. pmc An Aboriginal Australian genome reveals separate human dispersals into Asia
    Morten Rasmussen
    Centre for GeoGenetics, Natural History Museum of Denmark, Øster Voldgade 5 7, 1350 Copenhagen, Denmark
    Science 334:94-8. 2011
    ..Our findings support the hypothesis that present-day Aboriginal Australians descend from the earliest humans to occupy Australia, likely representing one of the oldest continuous populations outside Africa...
  59. pmc Genetic variants at 2q24 are associated with susceptibility to type 2 diabetes
    Lu Qi
    Department of Nutrition, Harvard School of Public Health, and Brigham and Women s Hospital, Boston, MA, USA
    Hum Mol Genet 19:2706-15. 2010
    ..05). These data suggest that the 2q24 locus may influence the T2D risk by affecting glucose metabolism and insulin resistance...
  60. pmc Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women
    Caroline S Fox
    Framingham Heart Study, National Heart, Lung, and Blood Institute, National Institutes of Health, Framingham, Massachusetts, United States of America
    PLoS Genet 8:e1002695. 2012
    ..More refined phenotypes for body composition and fat distribution can detect new loci not previously uncovered in large-scale GWAS of anthropometric traits...
  61. pmc Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways
    Lisette Stolk
    Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands
    Nat Genet 44:260-8. 2012
    ..Gene-set enrichment pathway analyses using the full GWAS data set identified exoDNase, NF-κB signaling and mitochondrial dysfunction as biological processes related to timing of menopause...
  62. ncbi Race and gender differences in C-reactive protein levels
    Amit Khera
    Donald W Reynolds Cardiovascular Clinical Research Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9047, USA
    J Am Coll Cardiol 46:464-9. 2005
    ..This study sought to determine whether there are race and gender differences in the distribution of C-reactive protein (CRP) levels...
  63. pmc Three genome-wide association studies and a linkage analysis identify HERC2 as a human iris color gene
    Manfred Kayser
    Department of Forensic Molecular Biology, Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands
    Am J Hum Genet 82:411-23. 2008
    ..Testing markers in the HERC2-OCA2 region may be useful in forensic applications to predict eye color phenotypes of unknown persons of European genetic origin...
  64. doi No significant association of 14 candidate genes with schizophrenia in a large European ancestry sample: implications for psychiatric genetics
    Alan R Sanders
    Department of Psychiatry and Behavioural Sciences, Evanston Northwestern Healthcare Research Institute, Evanston, IL 60201 3137, USA
    Am J Psychiatry 165:497-506. 2008
    ....
  65. ncbi Hypovitaminosis D prevalence and determinants among African American and white women of reproductive age: third National Health and Nutrition Examination Survey, 1988-1994
    Shanna Nesby-O'Dell
    Division of Nutrition and Physical Activity, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta 30341 3717, USA
    Am J Clin Nutr 76:187-92. 2002
    ..African American women are at higher risk of vitamin D deficiency than are white women, but few studies have examined determinants of hypovitaminosis D in this population...
  66. pmc Genome-wide association analysis identifies three new breast cancer susceptibility loci
    Maya Ghoussaini
    Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, UK
    Nat Genet 44:312-8. 2012
    ....
  67. pmc Gene copy-number variation and associated polymorphisms of complement component C4 in human systemic lupus erythematosus (SLE): low copy number is a risk factor for and high copy number is a protective factor against SLE susceptibility in European America
    Yan Yang
    Center for Molecular and Human Genetics, Columbus Children s Research Institute, Columbus, OH 43205, USA
    Am J Hum Genet 80:1037-54. 2007
    ..This work demonstrates how gene CNV and its related polymorphisms are associated with the susceptibility to a human complex disease...
  68. pmc Replication of genome-wide association studies (GWAS) loci for fasting plasma glucose in African-Americans
    E Ramos
    Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, 12 South Drive, MSC 5635, Bethesda, MD 20892, USA
    Diabetologia 54:783-8. 2011
    ..Thus, it is important to conduct replication analyses in populations with non-European ancestry to identify shared loci associated with FPG across populations...
  69. pmc HLA-A*3101 and carbamazepine-induced hypersensitivity reactions in Europeans
    Mark McCormack
    Molecular and Cellular Therapeutics, The Royal College of Surgeons in Ireland, Dublin, Ireland
    N Engl J Med 364:1134-43. 2011
    ..The HLA-B*1502 allele has been shown to be strongly correlated with carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS-TEN) in the Han Chinese and other Asian populations but not in European populations...
  70. ncbi A regional food-frequency questionnaire for the US Mississippi Delta
    Katherine L Tucker
    Jean Mayer US Department of Agriculture USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Public Health Nutr 8:87-96. 2005
    ....
  71. pmc Genetic and clinical predictors for breast cancer risk assessment and stratification among Chinese women
    Wei Zheng
    Vanderbilt Epidemiology Center, Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, 2525 West End Avenue, Nashville, TN 37203 1738, USA
    J Natl Cancer Inst 102:972-81. 2010
    ..No risk assessment model that incorporates both genetic and clinical predictors is currently available to predict breast cancer risk in this population...
  72. pmc Digital quantification of human eye color highlights genetic association of three new loci
    Fan Liu
    Department of Forensic Molecular Biology, Erasmus University Medical Center, Rotterdam, The Netherlands
    PLoS Genet 6:e1000934. 2010
    ..A model for predicting quantitative eye colors explained over 50% of trait variance in the Rotterdam Study. Over all our data exemplify that fine phenotyping is a useful strategy for finding genes involved in human complex traits...
  73. pmc Impact of common variants of PPARG, KCNJ11, TCF7L2, SLC30A8, HHEX, CDKN2A, IGF2BP2, and CDKAL1 on the risk of type 2 diabetes in 5,164 Indians
    Ganesh Chauhan
    Functional Genomics Unit, Institute of Genomics and Integrative Biology CSIR, Delhi, India
    Diabetes 59:2068-74. 2010
    ..We have studied the association of common variants in these eight genes with type 2 diabetes and related traits in Indians by combining the data from two independent case-control studies...
  74. pmc A genome-wide association study of serum uric acid in African Americans
    Bashira A Charles
    Center for Research on Genomics and Global Health, National Human Genome Research Institute, Bethesda, MD 20892, USA
    BMC Med Genomics 4:17. 2011
    ....
  75. pmc A major Y-chromosome haplogroup R1b Holocene era founder effect in Central and Western Europe
    Natalie M Myres
    Sorenson Molecular Genealogy Foundation, Salt Lake City, UT, USA
    Eur J Hum Genet 19:95-101. 2011
    ....
  76. pmc Complete Khoisan and Bantu genomes from southern Africa
    Stephan C Schuster
    Pennsylvania State University, Center for Comparative Genomics and Bioinformatics, 310 Wartik Lab, University Park, Pennsylvania 16802, USA
    Nature 463:943-7. 2010
    ..Adding the described variants to current databases will facilitate inclusion of southern Africans in medical research efforts, particularly when family and medical histories can be correlated with genome-wide data...
  77. doi Race and triple negative threats to breast cancer survival: a population-based study in Atlanta, GA
    Mary Jo Lund
    Department of Epidemiology, Rollins School of Public Health, Emory University, 1518 Clifton Road, NE, Atlanta, GA 30322, USA
    Breast Cancer Res Treat 113:357-70. 2009
    ..This study examines association of the ER/PR/HER2 subtypes with race and breast cancer survival...
  78. pmc Genetic architecture of transcript-level variation in humans
    Shiwei Duan
    Section of Hematology Oncology, Department of Medicine, University of Chicago, Chicago, IL 60637, USA
    Am J Hum Genet 82:1101-13. 2008
    ..We highlight in the EPHX1 gene a deleterious nonsynonymous SNP that is distantly associated with gene expression of ORMDL3, a susceptibility gene for asthma...
  79. pmc The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans
    Nancy L Saccone
    Department of Genetics, Washington University, St Louis, Missouri 63110, UA
    Cancer Res 69:6848-56. 2009
    ..The nonsynonymous SNP rs16969968, a known risk variant in populations of European-descent, is also significantly associated with risk in African-Americans. Additional SNPs contribute to risk in distinct ways in these two populations...
  80. pmc Common variants in the trichohyalin gene are associated with straight hair in Europeans
    Sarah E Medland
    Queensland Institute of Medical Research, Brisbane 4029, Australia
    Am J Hum Genet 85:750-5. 2009
    ..5x10(-31)). These variants are at their highest frequency in Northern Europeans, paralleling the distribution of the straight-hair EDAR variant in Asian populations...
  81. pmc Acute effect of a single high-fat meal on forearm blood flow, blood pressure and heart rate in healthy male Asians and Caucasians: a pilot study
    Chumjit Bui
    Department of Health Promotion and Education, School of Public Health, Loma Linda University, Loma Linda, CA, USA
    Southeast Asian J Trop Med Public Health 41:490-500. 2010
    ..These findings suggest that a single HF meal may contribute to the detrimental effects on vascular health in Asian males and raises speculation regarding the cumulative impact of a chronic HF diet in this population...
  82. pmc Genome-wide association and genetic functional studies identify autism susceptibility candidate 2 gene (AUTS2) in the regulation of alcohol consumption
    Gunter Schumann
    Medical Research Council Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College, London SE5 8AF, United Kingdom
    Proc Natl Acad Sci U S A 108:7119-24. 2011
    ..001). Our finding of a regulator of alcohol consumption adds knowledge to our understanding of genetic mechanisms influencing alcohol drinking behavior...
  83. doi Genomic and geographic distribution of SNP-defined runs of homozygosity in Europeans
    Michael Nothnagel
    Institute of Medical Informatics and Statistics, Christian Albrechts University, 24105 Kiel, Germany
    Hum Mol Genet 19:2927-35. 2010
    ..As a consequence, the planning, design and interpretation of ROH-based genetic studies must take sample origin into account in order for such studies to be sensible and valid...
  84. doi Origins and genetic legacy of Neolithic farmers and hunter-gatherers in Europe
    Pontus Skoglund
    Department of Evolutionary Biology, Evolutionary Biology Centre, Uppsala University, Uppsala, Sweden
    Science 336:466-9. 2012
    ..Our results suggest that migration from southern Europe catalyzed the spread of agriculture and that admixture in the wake of this expansion eventually shaped the genomic landscape of modern-day Europe...
  85. pmc The relationship of waist circumference and BMI to visceral, subcutaneous, and total body fat: sex and race differences
    Sarah M Camhi
    Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA
    Obesity (Silver Spring) 19:402-8. 2011
    ..Sex differences, and in some instances race differences, in the relationships between anthropometry and fat-specific depots demonstrate that these characteristics need to be considered when predicting adiposity from WC or BMI...
  86. ncbi State of disparities in cardiovascular health in the United States
    George A Mensah
    Office of the Director, Division of Adult and Community Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control, Mail Stop K 40, 4770 Buford Hwy NE, Atlanta, GA 30341 3717, USA
    Circulation 111:1233-41. 2005
    ..Having timely access to current data on disparities is important for policy and program development. Accordingly, we assessed the current magnitude of disparities in cardiovascular disease (CVD) and its risk factors in the United States...
  87. ncbi Breast cancer in African-American women: differences in tumor biology from European-American women
    Kandace Amend
    Department of Oncological Sciences, Mount Sinai School of Medicine, New York, New York, USA
    Cancer Res 66:8327-30. 2006
    ..An overview of the current literature about racial differences in breast cancer prompts questions for future research to elucidate causes for the apparent disparities in tumor biology...
  88. pmc Disrupted in schizophrenia 1 (DISC1): association with schizophrenia, schizoaffective disorder, and bipolar disorder
    Colin A Hodgkinson
    Section of Human Neurogenetics and Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, Rockville, MD, USA
    Am J Hum Genet 75:862-72. 2004
    ..These data support the idea that these apparently distinct disorders have at least a partially convergent etiology and that variation at the DISC1 locus predisposes individuals to a variety of psychiatric disorders...
  89. pmc Color and genomic ancestry in Brazilians
    Flavia C Parra
    Departamento de Bioquimica e Imunologia, Universidade Federal de Minas Gerais, 31270 901 Belo Horizonte, Brazil
    Proc Natl Acad Sci U S A 100:177-82. 2003
    ..Our data suggest that in Brazil, at an individual level, color, as determined by physical evaluation, is a poor predictor of genomic African ancestry, estimated by molecular markers...
  90. ncbi Validation of the Framingham coronary heart disease prediction scores: results of a multiple ethnic groups investigation
    R B D'Agostino
    Department of Mathematics and Statistics, Boston University, 111 Cummington St, Boston, MA 02215, USA
    JAMA 286:180-7. 2001
    ..Concern exists regarding whether these functions can be generalized to other populations...
  91. ncbi The structure of haplotype blocks in the human genome
    Stacey B Gabriel
    Whitehead MIT Center for Genome Research, Cambridge, MA 02139, USA
    Science 296:2225-9. 2002
    ..Our results provide a foundation for the construction of a haplotype map of the human genome, facilitating comprehensive genetic association studies of human disease...
  92. ncbi Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers
    Hisayuki Shigematsu
    Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, TX 75390 8593, USA
    J Natl Cancer Inst 97:339-46. 2005
    ..However, the role of such mutations in the pathogenesis of lung cancers is unclear...
  93. ncbi Visceral adipose tissue accumulation differs according to ethnic background: results of the Multicultural Community Health Assessment Trial (M-CHAT)
    Scott A Lear
    School of Kinesiology, Simon Fraser University, Vancouver, BC, Canada
    Am J Clin Nutr 86:353-9. 2007
    ..Previous studies have not adequately investigated differences in discrete regions of abdominal adiposity across ethnic groups...
  94. pmc The shaping of modern human immune systems by multiregional admixture with archaic humans
    Laurent Abi-Rached
    Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Science 334:89-94. 2011
    ..Thus, adaptive introgression of archaic alleles has significantly shaped modern human immune systems...
  95. doi Will all Americans become overweight or obese? estimating the progression and cost of the US obesity epidemic
    Youfa Wang
    Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
    Obesity (Silver Spring) 16:2323-30. 2008
    ..Timely, dramatic, and effective development and implementation of corrective programs/policies are needed to avoid the otherwise inevitable health and societal consequences implied by our projections ...
  96. pmc Genetic susceptibility to obesity and related traits in childhood and adolescence: influence of loci identified by genome-wide association studies
    Marcel den Hoed
    Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Cambridge, UK
    Diabetes 59:2980-8. 2010
    ..We examined associations of variants in these loci with anthropometric traits in children and adolescents...
  97. ncbi Contextual analysis of breast and cervical cancer screening and factors associated with health care access among United States women, 2002
    Steven S Coughlin
    Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Soc Sci Med 66:260-75. 2008
    ..A significant interaction was also observed between the percentage of county female population who were Hispanic and the percentage who were non-Hispanic Black...
  98. ncbi The relationship of ethnicity, socioeconomic factors, and overweight in US adolescents
    Penny Gordon-Larsen
    University of North Carolina, Department of Nutrition, School of Public Health, Chapel Hill, NC 27516 3997, USA
    Obes Res 11:121-9. 2003
    ..To examine the extent to which race/ethnic differences in income and education account for sex-specific disparities in overweight prevalence in white, African American, Hispanic, and Asian U.S. teens...
  99. pmc Identification of a systemic lupus erythematosus susceptibility locus at 11p13 between PDHX and CD44 in a multiethnic study
    Christopher J Lessard
    Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    Am J Hum Genet 88:83-91. 2011
    ....
  100. pmc The timing of pigmentation lightening in Europeans
    Sandra Beleza
    IPATIMUP, Instituto de Patologia e Imunologia Molecular da Universidade do Porto, Porto, Portugal
    Mol Biol Evol 30:24-35. 2013
    ..We suggest that these patterns were influenced by recent increases in size of human populations, which favored the accumulation of advantageous variants at different loci...
  101. ncbi The reasons for geographic and racial differences in stroke study: objectives and design
    Virginia J Howard
    Department of Epidemiology, University of Alabama at Birmingham, USA
    Neuroepidemiology 25:135-43. 2005
    ..Participants are followed via telephone at 6-month intervals for identification of stroke events. The novel aspects of the REGARDS study allow for the creation of a national cohort to address geographic and ethnic differences in stroke...

Research Grants79

  1. A MicroRNA Approach to Screen for Sporadic Colon Cancer Exfoliately in Human Stoo
    Farid E Ahmed; Fiscal Year: 2010
    ..However, larger well designed clinical studies are needed to corroborate initial results. ..
  2. Parathyroid Hormone & Vitamin D Effects on Salt Sensitivity and Vascular Function
    ANNA LIZA BELEN VALINA TOTH; Fiscal Year: 2010
    ....
  3. JACKSON HEART STUDY
    HERMAN ALFRED TAYLOR; Fiscal Year: 2009
    ..abstract_text> ..
  4. JACKSON HEART STUDY
    Asoka Srinivasan; Fiscal Year: 2010
    ..abstract_text> ..
  5. JACKSON HEART STUDY
    HERMAN ALFRED TAYLOR; Fiscal Year: 2009
    ..abstract_text> ..
  6. JACKSON HEART STUDY
    ASOKA S SRINIVASAN; Fiscal Year: 2011
    ..abstract_text> ..
  7. JACKSON HEART STUDY
    Herman Taylor; Fiscal Year: 2010
    ..abstract_text> ..
  8. JACKSON HEART STUDY
    ASOKA S SRINIVASAN; Fiscal Year: 2013
    ..abstract_text> ..
  9. Addressing Psychosocial Disparities in Rural Hispanic Cancer Survivors
    Rachel M Ceballos; Fiscal Year: 2013
    ..abstract_text> ..
  10. Improving Hmong Health through Community Based Participatory Research
    DIAN LORENE BAKER; Fiscal Year: 2013
    ..The goal of this study is to assist in meeting the Healthy People 2020 objectives (D 2-14) for Hmong community members with Type 2 diabetes mellitus and improve health outcomes. ..
  11. Mediators of Atherosclerosis in South Asians Living in America
    Alka M Kanaya; Fiscal Year: 2013
    ..centers to identify risk factors linked to subclinical atherosclerosis and incident cardiovascular disease. These will provide targets for future therapies to prevent or cure the leading cause of death worldwide, cardiovascular disease. ..
  12. Telomere and its bio-regulators as predictors for clinical diabetes in women
    Simin Liu; Fiscal Year: 2010
    ....
  13. A dataset for the study of the social determinants of health.
    Peter A Muennig; Fiscal Year: 2010
    ..This dataset will greatly advance scientific understanding of the social causation of disease and health disparities. ..
  14. Endogenous Cardiac Glycosides in AASK
    Brad C Astor; Fiscal Year: 2010
    ..This information may help identify targets for treatment or prevention to reduce the high risk of cardiovascular disease in patients with chronic kidney disease. ..
  15. Identification of Biomarkers for Early Detection of Renal Cell Carcinoma
    Othon Iliopoulos; Fiscal Year: 2012
    ..In addition they may be used as surrogate markers for response to therapy and allow for early changes in biotherapy or targeted molecular therapy in case these latter ones do not work. ..
  16. Ethnic/Racial Variation in Intracerebral Hemorrhage (ERICH)
    Daniel Woo; Fiscal Year: 2013
    ..Yet we know little about the biologic differences that lead to this ethnic disparity. Our proposal will compare minorities with ICH to controls from the same population as well as explore genetic, radiographic and outcomes differences. ..
  17. Characterizing Mitochondrial DNA Susceptibility to Breast, Colorectal, and Prosta
    Iona Cheng; Fiscal Year: 2012
    ..In addition, we will evaluate heterogeneity of effects by disease sub-groups, environmental factors and known genetic risk factors. ..
  18. Randomized Trial of a Postpartum Diabetes Prevention Program for Hispanic Women
    Lisa Chasan-Taber; Fiscal Year: 2013
    ..Measures of adherence will include accelerometers and dietary recalls. ..
  19. Pilot Study of Arsenic, UV and Melanoma in a Non-Hispanic White Population
    Janice W Yager; Fiscal Year: 2011
    ....
  20. CARDIA Echocardiography Reading Center
    Joao A C Lima; Fiscal Year: 2012
    ..abstract_text> ..
  21. Effects of Vitamin D and Marine Omega-3 Fatty Acids on Anemia in the Elderly
    Nancy Berliner; Fiscal Year: 2013
    ..abstract_text> ..
  22. CARDIA ECHO RC CAN 9-8470189
    Joao Lima; Fiscal Year: 2009
    ..abstract_text> ..
  23. CARDIA ECHO RC
    Joao A C Lima; Fiscal Year: 2011
    ..abstract_text> ..
  24. CARDIA ECHO RC
    Joao Lima; Fiscal Year: 2010
    ..abstract_text> ..
  25. CARDIA
    Sharina D Person; Fiscal Year: 2010
    ..abstract_text> ..
  26. CARDIA
    O Dale Williams; Fiscal Year: 2011
    ..abstract_text> ..
  27. Coronary Artery Risk Development in Young Adults (CARDIA) Study - CC
    James Shikany; Fiscal Year: 2012
    ..abstract_text> ..
  28. Using Mixed Reality to build peer resistance skills in Latina middle schoolers
    ANNE E contact NORRIS; Fiscal Year: 2010
    ..Study results will also be helpful to other researchers developing technology based health games designed to promote health. ..
  29. RCT of Stress Reduction in the Secondary Prevention of CHD in African Americans
    Robert Schneider; Fiscal Year: 2010
    ....
  30. Chinese American Eye Study
    Rohit Varma; Fiscal Year: 2013
    ..These findings are also likely to be of increasing public health importance, as the societal burden of age-related eye disease will likely increase with the aging of this rapidly growing segment of the US population. ..
  31. STROKE INCIDENCE AND RISK FACTORS IN A TRI-ETHNIC REGION
    Ralph L Sacco; Fiscal Year: 2013
    ..We need to understand the importance of these conditions in predicting stroke, MI, vascular death, and determining cognitive decline among minority populations. ..
  32. Genome Wide Admixture Scan for Multiple Myeloma in African Americans
    CHRISTOPHER ALAN HAIMAN; Fiscal Year: 2013
    ..Our ultimate goal is to reduce the health disparity experienced by African Americans due to this fatal cancer. ..
  33. Hampton University Skin of Color Research Institute Skin of Color Symposium 2011:
    Meena Katdare; Fiscal Year: 2011
    ....
  34. Perfluoroalkyl chemicals and the risk of developing clinical and subclinical CVD
    Anoop Shankar; Fiscal Year: 2012
    ..We will study the association between blood PFCs and cardiovascular disease. If we find an association, it indirectly suggests that reducing PFCs may have a role in preventing these diseases. ..
  35. Epidemiologic Study of Sick Sinus Syndrome
    Alvaro Alonso; Fiscal Year: 2012
    ....
  36. Coronary Artery Risk Development in Young Adults (CARDIA) Study - Field Center
    KIANG J LIU; Fiscal Year: 2013
    ..abstract_text> ..
  37. Coronary Artery Risk Development in Young Adults (CARDIA) Study - Field Center
    KIANG J LIU; Fiscal Year: 2012
    ..abstract_text> ..
  38. CARDIA
    KIANG J LIU; Fiscal Year: 2010
    ..abstract_text> ..
  39. CARDIA
    KIANG J LIU; Fiscal Year: 2011
    ..abstract_text> ..
  40. CARDIA
    KIANG J LIU; Fiscal Year: 2009
    ..abstract_text> ..
  41. Melanoma Prevention: Using the Sun
    Marianne Berwick; Fiscal Year: 2013
    ..The NCI clearly states that prevention must be based on knowledge developed by integrative population science teams working in the population and in the laboratory. ..
  42. Coronary Artery Risk Development in Young Adults (CARDIA) Study - Field Center
    Pamela Schreiner; Fiscal Year: 2013
    ..abstract_text> ..
  43. Coronary Artery Risk Development in Young Adults (CARDIA) - Field Center
    Cora E Lewis; Fiscal Year: 2012
    ..abstract_text> ..
  44. CARDIA
    Cora E Lewis; Fiscal Year: 2009
    ..abstract_text> ..
  45. CARDIA
    Cora E Lewis; Fiscal Year: 2010
    ..abstract_text> ..
  46. Coronary Artery Risk Development in Young Adults (CARDIA) Study - Field Center
    Pamela Schreiner; Fiscal Year: 2012
    ..abstract_text> ..
  47. Coronary Artery Risk Development in Young Adults (CARDIA) - Field Center
    Cora E Lewis; Fiscal Year: 2013
    ..abstract_text> ..
  48. The Johnston County OA Project: Arthritis and Disability
    Joanne M Jordan; Fiscal Year: 2013
    ..By examining these factors in multiple aspects of the OA process in both ethnic groups within one study, efficiency and significant impact upon the public health can be maximized. ..
  49. CARDIA
    Stephen Sidney; Fiscal Year: 2009
    ..abstract_text> ..
  50. Coronary Artery Risk Development in Young Adults (CARDIA) Study - Field Center
    Stephen Sidney; Fiscal Year: 2013
    ..abstract_text> ..
  51. CARDIA
    Sharina Person; Fiscal Year: 2009
    ..abstract_text> ..
  52. Coronary Artery Risk Development in Young Adults (CARDIA) Study - Field Center
    Stephen Sidney; Fiscal Year: 2012
    ..abstract_text> ..
  53. CARDIA
    Pamela J Schreiner; Fiscal Year: 2009
    ..abstract_text> ..
  54. CARDIA
    Pamela Schreiner; Fiscal Year: 2011
    ..abstract_text> ..
  55. CARDIA
    Pamela J Schreiner; Fiscal Year: 2010
    ..abstract_text> ..
  56. CARDIA
    Cora E Lewis; Fiscal Year: 2011
    ..abstract_text> ..
  57. CARDIA
    Stephen Sidney; Fiscal Year: 2011
    ..abstract_text> ..
  58. CARDIA
    Stephen Sidney; Fiscal Year: 2010
    ..abstract_text> ..
  59. Gene Networks for Prostate Cancer Progression
    Leif Peterson; Fiscal Year: 2005
    ..Characterization of the FGFR1 and FGFR2 pathways in prostate cancer will contribute to the molecular understanding and early detection of patients that may experience rapid progression of metastases. ..
  60. Race, Ethnicity, Nativity and Housing Outcomes in Los Angeles
    EILEEN DIAZ MCCONNELL; Fiscal Year: 2010
    ....
  61. Sources of Change and Stability in Low-Income Black Marriages
    BENJAMIN REUVEN KARNEY; Fiscal Year: 2010
    ..These data will be combined with data from an ongoing study of low-income Hispanic newlyweds in order to identify the sources of differences in marital outcomes for these two similarly underprivileged groups ..
  62. UNIVERSITY OF NEW MEXICO CANCER CENTER PLANNING GRANT
    Cheryl Willman; Fiscal Year: 2004
    ..abstract_text> ..
  63. HCV TREATMENT IN AFRICAN AMERICANS VS NON HISPANIC WHIT*
    Lennox Jeffers; Fiscal Year: 2005
    ..SPECIFIC AIM 7. To identify sociodemographic (e.g., age, education income, gender, ethnicity) and psychosocial (e.g., anxiety, depression, coping) predictors of adherence to treatment and virologic response to HCV RNA. ..
  64. RACE AND ETHNIC DIFFERENCES IN U.S. BIRTH OUTCOMES
    Michael Grossman; Fiscal Year: 1990
    ..Can the upward trend in the percentage of illegitimate births explain the modest decline in the percentage of light births in the face of a rapid increase over time in the prompt initiation of prenatal care, especially among minorities?..
  65. GENETICS OF BLOOD PRESSURE CONTROL IN MEXICAN AMERICANS
    Larry Atwood; Fiscal Year: 2000
    ..Finally, all loci that have detectable effects on the intermediate phenotypes will be tested for their effects on blood pressure. ..
  66. VIRAHEP-C Clinical Center
    Anna Lok; Fiscal Year: 2005
    ..abstract_text> ..
  67. Dose-dependent anti-inflammatory effects of vitamin D in a human gingivitis model
    Raul Garcia; Fiscal Year: 2009
    ....
  68. Intensive Outpatient v. Outpatient Treatment with Buprenorphine among African Ame
    Shannon Gwin Mitchell; Fiscal Year: 2010
    ....
  69. Disparities in CHD in the Jackson Heart Study
    Mario Sims; Fiscal Year: 2010
    ..This research will also show which factors health policy makers need to focus on in order to address and eliminate CHD disparities. ..
  70. Racial & Ethnic Disparities in Incidence and Inpatient Outcomes of Acute Stroke
    Amresh D Hanchate; Fiscal Year: 2010
    ..For effective targeting of interventions and public policy, our study aims to use evidence to identify and prioritize modifiable factors appropriate for each minority cohort. ..
  71. Resistance to Antiviral Therapy in Chronic Hepatitis C
    Norah Terrault; Fiscal Year: 2005
    ..Moreover, the methodologies developed for patient outreach within the context of this collaborative study will serve as a model for enhancing participation of African Americans in clinical research. ..
  72. INCIDENCE OF DIABETES AND CVD IN MEXICAN AMERICANS
    Michael Stern; Fiscal Year: 2002
    ..The investigators note that this will aid in the interpretation of data relating to possible ethnic differences in cause-specific mortality based on death certificate coding. ..
  73. Using Doctor-Patient Teams to Reduce Health Disparities
    Louis Penner; Fiscal Year: 2007
    ..If successful, the study should provide an exportable means of improving communication between physicians and minority group patients and reducing disparities in health care. [unreadable] [unreadable] [unreadable]..
  74. Racial/Ethnic Disparities and High Volume Hospitals
    Bradford Gray; Fiscal Year: 2003
    ..S. Methodologically, we will explore a number of measurement issues, including the effects of alternative ways of operationalizing high volume and proximity. ..