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Genomes and Genes
| european continental ancestry groupSummarySummary: Individuals whose ancestral origins are in the continent of Europe. Top Publications
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Publications
Occurrence of torus palatinus and mandibularis among women of different ethnic groupsA A Chohayeb
Howard University, Washington DC, USA
Am J Dent 14:278-80. 2001..The presence of both tori was only detected in 8.4% of the participants. There was no relationship between age and the presence of torus mandibularis (r = 0.074) or palatinus (r = 0.008)...
Loci influencing lipid levels and coronary heart disease risk in 16 European population cohortsYurii S Aulchenko
1 Department of Epidemiology and Biostatistics, Erasmus University Medical Center, P O Box 2040, 3000 CA Rotterdam, The Netherlands 2 These authors contributed equally to this work
Nat Genet 41:47-55. 2009..001) and coronary heart disease incidence (P = 0.04). The genetic risk score improves the screening of high-risk groups of dyslipidemia over classical risk factors...
Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination SurveyEarl S Ford
Centers for Disease Control and Prevention, 1600 Clifton Rd NE, Mailstop E 17, Atlanta, GA 30333
JAMA 287:356-9. 2002..Limited information is available about the prevalence of the metabolic syndrome in the United States, however...
Complete Khoisan and Bantu genomes from southern AfricaStephan C Schuster
Pennsylvania State University, Center for Comparative Genomics and Bioinformatics, 310 Wartik Lab, University Park, Pennsylvania 16802, USA
Nature 463:943-7. 2010..Adding the described variants to current databases will facilitate inclusion of southern Africans in medical research efforts, particularly when family and medical histories can be correlated with genome-wide data...
Runs of homozygosity in European populationsRuth McQuillan
Public Health Sciences, University of Edinburgh Medical School, Edinburgh EH8 9AG, UK
Am J Hum Genet 83:359-72. 2008....
The structure of haplotype blocks in the human genomeStacey B Gabriel
Whitehead/MIT Center for Genome Research, Cambridge, MA 02139, USA
Science 296:2225-9. 2002..Our results provide a foundation for the construction of a haplotype map of the human genome, facilitating comprehensive genetic association studies of human disease...
Color and genomic ancestry in BraziliansFlavia C Parra
Departamento de Bioquimica e Imunologia, Universidade Federal de Minas Gerais, 31270-901 Belo Horizonte, Brazil
Proc Natl Acad Sci U S A 100:177-82. 2003..Our data suggest that in Brazil, at an individual level, color, as determined by physical evaluation, is a poor predictor of genomic African ancestry, estimated by molecular markers...
Genetic variation in GPR133 is associated with height: genome wide association study in the self-contained population of SorbsAnke Tonjes
Department of Medicine, University of Leipzig, Leipzig, Germany
Hum Mol Genet 18:4662-8. 2009..7 x 10(-8) (beta = 0.949). In conclusion, our GWAS suggests novel loci influencing height. In view of the robust replication in five different cohorts, we propose GPR133 to be a novel gene associated with adult height...
Genome-wide association and replication studies identify four variants associated with prostate cancer susceptibilityJulius Gudmundsson
deCODE Genetics, Reykjavik, Iceland
Nat Genet 41:1122-6. 2009..3% of the risk distribution are at a 2.5 times greater risk of developing the disease than members of the general population...
A genome-wide association study identifies a new ovarian cancer susceptibility locus on 9p22.2Honglin Song
Cancer Research UK Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK
Nat Genet 41:996-1000. 2009..82, 95% confidence interval (CI) 0.79-0.86, P(trend) = 5.1 x 10(-19)). The association differs by histological subtype, being strongest for serous ovarian cancers (OR 0.77, 95% CI 0.73-0.81, P(trend) = 4.1 x 10(-21))...
Contribution of major diseases to disparities in mortalityMitchell D Wong
Division of General Internal Medicine and Health Services Research, University of California at Los Angeles, Los Angeles 90095 1736, USA
N Engl J Med 347:1585-92. 2002..Mortality from all causes is higher for persons with fewer years of education and for blacks, but it is unknown which diseases contribute most to these disparities...
Genetic structure of Europeans: a view from the North-EastMari Nelis
Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia
PLoS ONE 4:e5472. 2009..Together with previously published data, our results allow the creation of a comprehensive European genetic map that will greatly facilitate inter-population genetic studies including genome wide association studies (GWAS)...
Asians are different from Caucasians and from each other in their body mass index/body fat per cent relationshipP Deurenberg
Wageningen University, The Netherlands
Obes Rev 3:141-6. 2002..Hence, the relationship between BF% and BMI is ethnic-specific. For comparisons of obesity prevalence between ethnic groups, universal BMI cut-off points are not appropriate...
Candidate gene association resource (CARe): design, methods, and proof of conceptKiran Musunuru
Broad Institute, Cambridge, MA 02142, USA
Circ Cardiovasc Genet 3:267-75. 2010..The goals of CARe include the discovery of new variants associated with traits using a candidate gene approach and the discovery of new variants using the genome-wide association mapping approach specifically in African Americans...
SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populationsHiroyuki Unoki
Laboratory for Endocrinology and Metabolism, Center for Genomic Medicine, RIKEN, Yokohama, Kanagawa 230 0045, Japan
Nat Genet 40:1098-102. 2008..5 x 10(-3); OR = 1.14, rs2237897, P = 2.4 x 10(-4); OR = 1.22) and Danish populations (additive model: rs2237895, P = 3.7 x 10(-11); OR = 1.24, rs2237897, P = 1.2 x 10(-4); OR = 1.36)...
Factors influencing cotinine half-life during smoking abstinence in African American and Caucasian womenKaren L Ahijevych
Ohio State University College of Nursing, Columbus 43210, USA
Nicotine Tob Res 4:423-31. 2002..To improve accuracy in correctly classifying non-smokers with cotinine levels, a period of at least 7 days of smoking abstinence may be warranted...
Mentholated cigarettes and smoking habits in whites and blacksJ E Muscat
American Health Foundation, Valhalla, New York 10595, USA
Tob Control 11:368-71. 2002..To determine if cigarette mentholation is associated with the frequency of smoking and with quitting, and whether mentholation explains racial differences in these two smoking behaviours...
Mentholated cigarette smoking inhibits nicotine metabolismNeal L Benowitz
Division of Clinical Pharmacology and Experimental Therapeutics, University of California, San Francisco, Box 1220, San Francisco, CA 94143 1220, USA
J Pharmacol Exp Ther 310:1208-15. 2004..Our finding of impaired metabolism of nicotine while mentholated cigarette smoking suggests that mentholated cigarette smoking enhances systemic nicotine exposure...
Ancestry informative marker sets for determining continental origin and admixture proportions in common populations in AmericaRoman Kosoy
Rowe Program in Human Genetics, Department of Biochemistry, University of California Davis, Davis, California 95616, USA
Hum Mutat 30:69-78. 2009..We conclude that investigators can use TaqMan assays for the selected AIMs as a simple and cost efficient tool to control for differences in continental ancestry when conducting association studies in ethnically diverse populations...
Effects of insulin resistance and type 2 diabetes on lipoprotein subclass particle size and concentration determined by nuclear magnetic resonanceW Timothy Garvey
Division of Endocrinology and Department of Medicine, Medical University of South Carolina, Charleston 29425, USA
Diabetes 52:453-62. 2003..It will be important to study whether NMR lipoprotein subclass parameters can be used to manage risk more effectively and prevent cardiovascular disease in patients with the IRS...
Common genetic variation near melatonin receptor MTNR1B contributes to raised plasma glucose and increased risk of type 2 diabetes among Indian Asians and European CaucasiansJohn C Chambers
Department of Epidemiology and Public Health, Imperial College London, London, U K
Diabetes 58:2703-8. 2009..Fasting plasma glucose and risk of type 2 diabetes are higher among Indian Asians than among European and North American Caucasians. Few studies have investigated genetic factors influencing glucose metabolism among Indian Asians...
Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with HeightMatthew B Lanktree
Department of Medicine and Biochemistry, University of Western Ontario, London, Ontario, N6A 5C1, Canada
Am J Hum Genet 88:6-18. 2011..Overall, we show that dense coverage of genes for uncommon SNPs, coupled with large-scale meta-analysis, can successfully identify additional variants associated with a common complex trait...
State of disparities in cardiovascular health in the United StatesGeorge A Mensah
Office of the Director, Division of Adult and Community Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control, Mail Stop K 40, 4770 Buford Hwy NE, Atlanta, GA 30341 3717, USA
Circulation 111:1233-41. 2005..Having timely access to current data on disparities is important for policy and program development. Accordingly, we assessed the current magnitude of disparities in cardiovascular disease (CVD) and its risk factors in the United States...
Racial/ethnic differences in hypertension and hypertension treatment and control in the multi-ethnic study of atherosclerosis (MESA)Holly Kramer
Department of Preventive Medicine, Loyola University, Chicago, Illinois, USA
Am J Hypertens 17:963-70. 2004..Most previous studies investigating the association between ethnicity and hypertension focused on differences between African Americans and whites and did not include other racial/ethnic groups such as Chinese or Hispanics...
High-density SNP genotyping detects homogeneity of Spanish and French Basques, and confirms their genomic distinctiveness from other European populationsNaiara Rodriguez-Ezpeleta
Genome Analysis Platform, Functional Genomics Unit, CIC bioGUNE, Bizkaia Technology Park, Building 502, 48160, Derio, Spain
Hum Genet 128:113-7. 2010..Here, we present the first high-throughput analysis including Basques from Spanish and French provinces, and show that all Basques constitute a homogeneous group that can be clearly differentiated from other European populations...
Genetic variation in the SMAD3 gene is associated with hip and knee osteoarthritisAna M Valdes
Department of Twin Research and Genetic Epidemiology, St Thomas Hospital Campus, King s College London, London SE1 7EH, UK
Arthritis Rheum 62:2347-52. 2010..We undertook this study to investigate the role of genetic variation in SMAD3 in the risk of large-joint OA in humans...
Genetic differences between the determinants of lipid profile phenotypes in African and European Americans: the Jackson Heart StudyRahul C Deo
Department of Genetics, Harvard Medical School, Boston, MA, USA
PLoS Genet 5:e1000342. 2009....
Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studiesFernando Rivadeneira
Department of Internal Medicine, Rotterdam, The Netherlands
Nat Genet 41:1199-206. 2009..The many SNPs associated with BMD map to genes in signaling pathways with relevance to bone metabolism and highlight the complex genetic architecture that underlies osteoporosis and variation in BMD...
Blood pressure and hypertension in relation to levels of serum polychlorinated biphenyls in residents of Anniston, AlabamaAlexey Goncharov
Department of Environmental Health Sciences, School of Public Health, University at Albany, Rensselaer, New York 12144, USA
J Hypertens 28:2053-60. 2010..To determine risk factors for elevated blood pressure and hypertension in residents of Anniston, Alabama who live near a plant that manufactured polychlorinated biphenyls (PCBs)...
Genome-wide association study identifies new HLA class II haplotypes strongly protective against narcolepsyHyun Hor
Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland
Nat Genet 42:786-9. 2010..Cases almost never carried a trans DRB1*1301-DQB1*0603 haplotype (odds ratio = 0.02; P < 6 x 10(-14)). This unexpected protective HLA haplotype suggests a virtually causal involvement of the HLA region in narcolepsy susceptibility...
Meta-analysis of genome-wide scans for human adult stature identifies novel Loci and associations with measures of skeletal frame sizeNicole Soranzo
Human Genetics Department, Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom
PLoS Genet 5:e1000445. 2009..Further statistical tests in larger numbers of individuals will be required to verify if the height loci affect height preferentially through these subcomponents of height...
Older adults' perceived physical activity enablers and barriers: a multicultural perspectiveAnna E Mathews
Dept of Health and Exercise Science, Furman University, Greenville, SC, USA
J Aging Phys Act 18:119-40. 2010..Findings suggest several ways to promote PA among older people, including developing exercise programs designed for older adults and health messages promoting existing places and programs older adults can use to engage in PA...
Genetic association of insulin-like growth factor-1 polymorphisms with high-grade myopia in an international family cohortRavikanth Metlapally
Center for Human GeneticsDepartment of Biostatistics and Bioinformatics, Duke University Medical Center, Durham, NC 27710, USA
Invest Ophthalmol Vis Sci 51:4476-9. 2010..This study was conducted to determine whether IGF-1 polymorphisms are associated with myopia in a large, international dataset of Caucasian high-grade myopia pedigrees...
Comprehensive analysis of genomic variation in the LPA locus and its relationship to plasma lipoprotein(a) in South Asians, Chinese, and European CaucasiansMatthew B Lanktree
Department of Medicine and Biochemistry, Robarts Research Institute and Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada
Circ Cardiovasc Genet 3:39-46. 2010..Genomic analysis of LPA, including both single-nucleotide polymorphisms (SNPs) and kringle IV type 2 (KIV-2) copy number, has yet to be performed...
A genome-wide association study in 19 633 Japanese subjects identified LHX3-QSOX2 and IGF1 as adult height lociYukinori Okada
Center for Genomic Medicine, Institute of Physical and Chemical Research, RIKEN, Kanagawa, Japan
Hum Mol Genet 19:2303-12. 2010..26 cm (95% confidence interval: 1.18-1.34) per 1.0 increase of the normalized Z score for height-increasing alleles, explaining 4.6% of the total variance of adult height...
Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other lociJohn B Harley
Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, Oklahoma 73104, USA
Nat Genet 40:204-10. 2008..Our results show that numerous genes, some with known immune-related functions, predispose to SLE...
Coping and distress among women under treatment for early stage breast cancer: comparing African Americans, Hispanics and non-Hispanic WhitesJenifer L Culver
Department of Psychology, University of Miami, Coral Gables, FL 33124-2070, USA
Psychooncology 11:495-504. 2002..The data also provided evidence of a maladaptive spiral of distress and avoidant coping over time. Although some ethnic differences were identified, findings also point to a great many similarities across groups...
Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitusKazuki Yasuda
Department of Metabolic Disorder, Research Institute, International Medical Center of Japan, Tokyo 162 8655, Japan
Nat Genet 40:1092-7. 2008..Our data thus implicate KCNQ1 as a diabetes susceptibility gene in groups of different ancestries...
Menthol cigarettes and risk of lung cancerDaniel R Brooks
Department of Epidemiology, Boston University School of Public Health, Boston, MA 02118, USA
Am J Epidemiol 158:609-16; discussion 617-20. 2003..0 in separate analyses of male, female, Black, and White subjects. The results of this study do not support the hypothesis that smoking menthol cigarettes increases the risk of lung cancer relative to smoking nonmenthol cigarettes...
Relationship of alcohol consumption and type of alcoholic beverage consumed with plasma lipid levels: differences between Whites and African Americans of the ARIC studyKelly A Volcik
Human Genetics Center, University of Texas Health Science Center, Houston, TX 77030, USA
Ann Epidemiol 18:101-7. 2008..The influence of different types of alcoholic beverages on plasma lipid levels has been investigated to a lesser extent and in limited populations...
Visceral adipose tissue accumulation differs according to ethnic background: results of the Multicultural Community Health Assessment Trial (M-CHAT)Scott A Lear
School of Kinesiology, Simon Fraser University, Vancouver, BC, Canada
Am J Clin Nutr 86:353-9. 2007..Previous studies have not adequately investigated differences in discrete regions of abdominal adiposity across ethnic groups...
Racial differences in exposure to environmental tobacco smoke among childrenStephen E Wilson
Division of General Internal Medicine, University of Cincinnati, Cincinnati, Ohio, USA
Environ Health Perspect 113:362-7. 2005..Identifying causes and consequences of increased cotinine may help explain the striking differences in tobacco-related illnesses...
Body size, body composition and fat distribution: comparative analysis of European, Maori, Pacific Island and Asian Indian adultsElaine C Rush
Faculty of Health and Environmental Sciences, Centre for Physical Activity and Nutrition Research, AUT University, Private Bag 92006, Auckland 1020, New Zealand
Br J Nutr 102:632-41. 2009..The use of universal BMI cut-off points may not be appropriate for the comparison of obesity prevalence between ethnic groups...
Determinants of JNC VI guideline adherence, intensity of drug therapy, and blood pressure control by race and ethnicityLeRoi S Hicks
Division of General Internal Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Mass, USA
Hypertension 44:429-34. 2004..Interventions to reduce disparities in cardiovascular outcomes should consider the need to intensify drug therapy more aggressively among all high-risk populations...
Epistatic interaction between KIR3DS1 and HLA-B delays the progression to AIDSMaureen P Martin
Basic Research Program, SAIC Frederick, Frederick, Maryland 21702 1201, USA
Nat Genet 31:429-34. 2002..The strongest synergistic effect of these loci was on progression to depletion of CD4(+) T cells, which suggests that a protective response of NK cells involving KIR3DS1 and its HLA class I ligands begins soon after HIV-1 infection...
Impact of common variants of PPARG, KCNJ11, TCF7L2, SLC30A8, HHEX, CDKN2A, IGF2BP2, and CDKAL1 on the risk of type 2 diabetes in 5,164 IndiansGanesh Chauhan
Functional Genomics Unit, Institute of Genomics and Integrative Biology CSIR, Delhi, India
Diabetes 59:2068-74. 2010..We have studied the association of common variants in these eight genes with type 2 diabetes and related traits in Indians by combining the data from two independent case-control studies...
Gene variants associated with schizophrenia in a Norwegian genome-wide study are replicated in a large European cohortLavinia Athanasiu
Institute of Psychiatry, University of Oslo, P O 1130, Blindern, N 0318 Oslo, Norway
J Psychiatr Res 44:748-53. 2010..The association of ANK3 with schizophrenia is intriguing in light of recent associations of ANK3 with bipolar disorder, thereby supporting the hypothesis of an overlap in genetic susceptibility between these psychopathological entities...
A predominantly neolithic origin for European paternal lineagesPatricia Balaresque
Department of Genetics, University of Leicester, Leicester, United Kingdom
PLoS Biol 8:e1000285. 2010....
Influence of socioeconomic and cultural factors on racial differences in late-stage presentation of breast cancerD R Lannin
Department of Surgery, Leo W Jenkins Cancer Center, East Carolina University, Greenville, NC 27858, USA
JAMA 279:1801-7. 1998..Breast cancer mortality is higher among African American women than among white women in the United States, but the reasons for the racial difference are not known...
APOA2, dietary fat, and body mass index: replication of a gene-diet interaction in 3 independent populationsDolores Corella
Nutrition and Genomics Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, 711 Washington St, Boston, MA 02111 1524, USA
Arch Intern Med 169:1897-906. 2009..However, replication has been low. Our aim was to study interaction among a functional APOA2 polymorphism, food intake, and body mass index (BMI) in independent populations to replicate findings and to increase their evidence level...
Correlation of the leptin:adiponectin ratio with measures of insulin resistance in non-diabetic individualsF M Finucane
MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke s Hospital, Cambridge, UK
Diabetologia 52:2345-9. 2009..We sought to assess the usefulness of the LAR as a measure of insulin resistance in non-diabetic white adults...
Common variants in the trichohyalin gene are associated with straight hair in EuropeansSarah E Medland
Queensland Institute of Medical Research, Brisbane 4029, Australia
Am J Hum Genet 85:750-5. 2009..5x10(-31)). These variants are at their highest frequency in Northern Europeans, paralleling the distribution of the straight-hair EDAR variant in Asian populations...
MYH9 is associated with nondiabetic end-stage renal disease in African AmericansW H Linda Kao
Department of Epidemiology, School of Medicine and Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21287, USA
Nat Genet 40:1185-92. 2008....
Genetic variation in sex hormone genes influences heel ultrasound parameters in middle-aged and elderly men: results from the European Male Aging Study (EMAS)Kate L Limer
ARC Epidemiology Unit, The University of Manchester, Manchester, United Kingdom
J Bone Miner Res 24:314-23. 2009....
Lower quit rates among African American and Latino menthol cigarette smokers at a tobacco treatment clinicK K Gandhi
Division of Addiction Psychiatry, UMDNJ Robert Wood Johnson Medical School, New Brunswick, NJ 08901, USA
Int J Clin Pract 63:360-7. 2009..Lower rates of smoking cessation and higher rates of lung cancer in African American (AA) smokers may be linked to their preference for mentholated cigarettes...
A kinesin family member 6 variant is associated with coronary heart disease in the Women's Health StudyDov Shiffman
Celera, Alameda, California 94502, USA
J Am Coll Cardiol 51:444-8. 2008..We asked if carriers of the 719Arg allele of kinesin family member 6 (KIF6) have increased risk of coronary heart disease (CHD) in a cohort of initially healthy Caucasian American women...
Darwinian and demographic forces affecting human protein coding genesRasmus Nielsen
Department of Biology, University of Copenhagen, Copenhagen, Denmark
Genome Res 19:838-49. 2009..In accordance with previous studies, we find evidence for negative selection against mutations in genes associated with Mendelian disease and positive selection acting on genes associated with several complex diseases...
Genetic variations in nitric oxide synthase 1 adaptor protein are associated with sudden cardiac death in US white community-based populationsW H Linda Kao
Department of Epidemiology, Johns Hopkins University School of Medicine, 733 N Broadway, Baltimore, MD 21205, USA
Circulation 119:940-51. 2009....
Genetically elevated lipoprotein(a) and increased risk of myocardial infarctionPia R Kamstrup
Department of Clinical Biochemistry, Herlev Hospital, Herlev Ringvej 75, DK 2730 Herlev, Denmark
JAMA 301:2331-9. 2009..High levels of lipoprotein(a) are associated with increased risk of myocardial infarction (MI)...
Association between the IRF5 rs2004640 functional polymorphism and systemic sclerosis: a new perspective for pulmonary fibrosisP Dieude
Universite Paris 7, and Hôpital Bichat Claude Bernard, Assistance Publique Hopitaux de Paris, Paris, France
Arthritis Rheum 60:225-33. 2009..The aim of this study was to determine whether the IRF5 rs2004640 single-nucleotide polymorphism is associated with SSc...
Clinical pharmacology of nicotine: implications for understanding, preventing, and treating tobacco addictionN L Benowitz
Department of Medicine, University of California, San Francisco, California, USA
Clin Pharmacol Ther 83:531-41. 2008....
The Population Reference Sample, POPRES: a resource for population, disease, and pharmacological genetics researchMatthew R Nelson
GlaxoSmithKline, Research Triangle Park, NC 27709, USA
Am J Hum Genet 83:347-58. 2008..The genotype and demographic data from this reference sample are freely available through the NCBI database of Genotypes and Phenotypes (dbGaP)...
Common SNPs in HMGCR in micronesians and whites associated with LDL-cholesterol levels affect alternative splicing of exon13Ralph Burkhardt
Laboratory of Biochemical Genetics and Metabolism, The Rockefeller University, New York, NY 10065, USA
Arterioscler Thromb Vasc Biol 28:2078-84. 2008..Background- Variation in LDL-cholesterol (LDL-C) among individuals is a complex genetic trait involving multiple genes and gene-environment interactions...
Race-specific differences in endothelial function: predisposition of African Americans to vascular diseasesLeszek Kalinowski
Department of Biochemistry, Ohio University, Athens, OH 45701, USA
Circulation 109:2511-7. 2004..This may explain the differences in racial predisposition to the endothelium dysfunction during ongoing vascular disturbances with the hallmark of enhanced NO inactivation within the endothelium by oxidative stress...
Abraham's children in the genome era: major Jewish diaspora populations comprise distinct genetic clusters with shared Middle Eastern AncestryGil Atzmon
Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Am J Hum Genet 86:850-9. 2010..Thus, this study demonstrates that European/Syrian and Middle Eastern Jews represent a series of geographical isolates or clusters woven together by shared IBD genetic threads...
Racial disparities in hypertension prevalence, awareness, and managementRobin P Hertz
US Outcomes Research Population Studies, Pfizer Global Pharmaceuticals, New York, NY 10017, USA
Arch Intern Med 165:2098-104. 2005..Effectively reducing cardiovascular disease disparities requires identifying and reducing disparities in risk factors. Improved understanding of hypertension disparities is critical...
Genetic variant in HK1 is associated with a proanemic state and A1C but not other glycemic control-related traitsAmelie Bonnefond
CNRS UMR 8090, Institute of Biology and Lille 2 University, Pasteur Institute, Lille, France
Diabetes 58:2687-97. 2009..HK1 deficiency in erythrocytes (red blood cells [RBCs]) causes severe nonspherocytic hemolytic anemia in both humans and mice...
European bone mineral density loci are also associated with BMD in East-Asian populationsUnnur Styrkarsdottir
deCODE Genetics, Reykjavik, Iceland
PLoS ONE 5:e13217. 2010..0010) and 17q21 (SOST, P = 0.015). Our study marks an early effort towards the challenge of cataloguing bone density variants shared by many ethnicities by testing BMD variants that have been established in Europeans, in East-Asians...
Inferring continental ancestry of argentineans from Autosomal, Y-chromosomal and mitochondrial DNADaniel Corach
University of Buenos Aires, Argentina
Ann Hum Genet 74:65-76. 2010..This applies to all worldwide areas where people with different continental ancestry live geographically close together...
Ethnic differences of the presence and severity of coronary atherosclerosisMatthew J Budoff
Division of Cardiology, Los Angeles Biomedical Research Institute at Harbor UCLA, 1124 W Carson Street, Bldg RB 2, Torrance, CA, USA
Atherosclerosis 187:343-50. 2006..The objective of the study is to assess the differences in the prevalence and severity of coronary artery calcification, as a measure of atherosclerosis, in these different ethnic groups...
Contribution of regulatory and structural variations in APOE to predicting dyslipidemiaJari H Stengård
National Public Health Institute, Helsinki, Finland
J Lipid Res 47:318-28. 2006..Our study suggests that both regulatory and structural variations should be considered when evaluating the utility of APOE for predicting dyslipidemia in the population at large...
Analysis of the frequencies of HLA-A, B, and C alleles and haplotypes in the five major ethnic groups of the United States reveals high levels of diversity in these loci and contrasting distribution patterns in these populationsK Cao
American Red Cross National Histocompatibility Laboratory, Baltimore, Maryland, USA
Hum Immunol 62:1009-30. 2001..Differences in both LD and heterozygosity levels suggest distinct evolutionary histories of the HLA loci in the geographical regions from where the U.S. populations originated...
Racial/Ethnic differences in subclinical atherosclerosis among adults with diabetes: the multiethnic study of atherosclerosisMercedes R Carnethon
Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
Diabetes Care 28:2768-70. 2005
Haplotype spanning TTC12 and ANKK1, flanked by the DRD2 and NCAM1 loci, is strongly associated to nicotine dependence in two distinct American populationsJoel Gelernter
Division of Human Genetics, Department of Psychiatry, Yale University School of Medicine, West Haven, CT 06516, USA
Hum Mol Genet 15:3498-507. 2006..Functional studies of these loci are warranted. These results provide additional information useful in evaluating the many earlier discrepant findings regarding association of DRD2 with substance dependence...
A comparison of linkage disequilibrium patterns and estimated population recombination rates across multiple populationsDavid M Evans
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
Am J Hum Genet 76:681-7. 2005....
Measuring and using admixture to study the genetics of complex diseasesIndrani Halder
Department of Anthropology, Pennsylvania State University, University Park, PA 16801, USA
Hum Genomics 1:52-62. 2003..Finally, the article discusses some limitations of this approach that should be considered when designing an effective AM study...
Central corneal thickness of Caucasians, Chinese, Hispanics, Filipinos, African Americans, and Japanese in a glaucoma clinicElsa Aghaian
Department of Ophthalmology, University of California, San Francisco, California, USA
Ophthalmology 111:2211-9. 2004..Additionally, older individuals; glaucoma suspects; and participants with NTG, POAG, PEX, and CACG have thinner corneas. Ocular hypertensives, however, have thicker corneas...
SLC24A5, a putative cation exchanger, affects pigmentation in zebrafish and humansRebecca L Lamason
Jake Gittlen Cancer Research Foundation, Department of Pathology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
Science 310:1782-6. 2005....
Common genetic variation in IGF1 and prostate cancer risk in the Multiethnic CohortIona Cheng
Department of Preventive Medicine, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
J Natl Cancer Inst 98:123-34. 2006..Insulin-like growth factor I (IGF-I) appears to play a role in prostate development and carcinogenesis. We investigated whether genetic variation at the IGF1 locus is associated with prostate cancer risk...
Ethnic differences in C-reactive protein concentrationsAlyson Kelley-Hedgepeth
Molecular Cardiology Research Institute, Tufts Medical Center, Boston, MA, USA
Clin Chem 54:1027-37. 2008..We hypothesized that known CVD risk factors, including anthropometric characteristics, would explain much of the observed ethnic variation in CRP...
Impact of ethnicity and gender differences on angiographic coronary artery disease prevalence and in-hospital mortality in the American College of Cardiology-National Cardiovascular Data RegistryLeslee J Shaw
Emory Program in Cardiovascular Outcomes Research and Epidemiology, 1256 Briarcliff Rd NE, Suite 1 N, Emory University School of Medicine, Atlanta, GA 30306, USA
Circulation 117:1787-801. 2008..Although populations referred for coronary angiography are increasingly diverse, there is limited information on coronary artery disease (CAD) prevalence and in-hospital mortality other than for predominately white male patients...
No association between OPA1 polymorphisms and primary open-angle glaucoma in three different populationsYutao Liu
Center for Human Genetics, Duke University Medical Center, Durham, NC, USA
Mol Vis 13:2137-41. 2007....
Genetic and functional analysis of CHEK2 (CHK2) variants in multiethnic cohortsDaphne W Bell
Massachusetts General Hospital Cancer Center, Charlestown, MA, USA
Int J Cancer 121:2661-7. 2007....
Frequency of the frame-shifting CYP2D7 138delT polymorphism in a large, ethnically diverse sample populationAnahita Bhathena
Pharmacogenetics, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, Illinois 60064 6098, USA
Drug Metab Dispos 35:1251-3. 2007..Our results suggest that CYP2D7 138delT is unlikely to be highly relevant for population variation of pharmacokinetics or drug response...
Subclinical atherosclerotic cardiovascular disease and early age-related macular degeneration in a multiracial cohort: the Multiethnic Study of AtherosclerosisRonald Klein
Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison 53726 2397, USA
Arch Ophthalmol 125:534-43. 2007..To investigate the relationship of subclinical atherosclerotic cardiovascular disease (CVD) and its risk factors with age-related macular degeneration (AMD) in the Multiethnic Study of Atherosclerosis...
Genome-wide association study of prostate cancer identifies a second risk locus at 8q24Meredith Yeager
SAIC Frederick, National Cancer Institute NCI Frederick Cancer Research and Development Center, Frederick, Maryland 21702, USA
Nat Genet 39:645-9. 2007..We estimate that the population attributable risk of the new locus, marked by rs6983267, is higher than the locus marked by rs1447295 (21% versus 9%)...
Factors associated with prevalent and incident urinary incontinence in a cohort of midlife women: a longitudinal analysis of data: study of women's health across the nationL Elaine Waetjen
Department of Obstetrics and Gynecology, University of California, Davis, CA, USA
Am J Epidemiol 165:309-18. 2007..In midlife women, incident incontinence is mild with different characteristics and baseline risk factors; overweight women have a higher risk of developing incontinence...
Haplotype-based association studies of IGFBP1 and IGFBP3 with prostate and breast cancer risk: the multiethnic cohortIona Cheng
Department of Epidemiology and Biostatistics and Center for Human Genetics, University of California San Francisco, San Francisco, California, USA
Cancer Epidemiol Biomarkers Prev 15:1993-7. 2006..Our results suggest that common genetic variation in the IGFBP1 and IGFBP3 genes do not substantially influence prostate and breast cancer susceptibility...
KEL6 and KEL7 genotyping with sequence-specific primersKeli J Renoud
Department of Transfusion Medicine, Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland 20892-1184, USA
Transfusion 46:1510-4. 2006..The KEL polymorphism at 2019 is silent and this allele yields a Js(a-b+) phenotype. Only analysis of the 1910-bp SNP can be used to genotype KEL6 and KEL7...
Protective effect of apolipoprotein E2 on coronary artery disease in African Americans is mediated through lipoprotein cholesterolErdembileg Anuurad
Department of Medicine, University of California, Davis, CA, USA
J Lipid Res 47:2475-81. 2006....
Contrasting multi-site genotypic distributions among discordant quantitative phenotypes: the APOA1/C3/A4/A5 gene cluster and cardiovascular disease risk factorsBret A Payseur
Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York, USA
Genet Epidemiol 30:508-18. 2006..Results indicate that this multi-site test can identify genotype-phenotype associations with reasonable power, including those generated by some simple epistatic models...
Patterns of genetic variation in the hypertension candidate gene GRK4: ethnic variation and haplotype structureK E Lohmueller
Institute for Molecular and Human Genetics, Georgetown University Medical Center, Washington, DC, USA
Ann Hum Genet 70:27-41. 2006..Our results document not only different allele frequencies between populations, but differences in haplotype structure that may be important in evaluating association studies between hypertension and GRK4...
Stepping back to gain perspective: pregnancy loss history, depression, and parenting capacity in the Early Childhood Longitudinal Study, Birth Cohort (ECLS-B)Sarah Kye Price
School of Social Work, Virginia Commonwealth University, 1001 W Franklin St P O Box 842027, Richmond, VA 23284 2027, USA
Death Stud 32:97-122. 2008..Ultimately, the findings from this population-based research contribute to a wider perspective regarding maternal response to reproductive loss that can inform future research and targeted bereavement support...
Differences in ornithine decarboxylase and androgen receptor allele frequencies among ethnic groupsTHOMAS G O'BRIEN
Lankenau Institute for Medical Research, 100 Lancaster Avenue, Wynnewood, PA 19096, USA
Mol Carcinog 41:120-123. 2004..8 (African-Americans) to 25.1 (Hispanics). It is possible that ethnic differences in risk alleles for ODC and AR may account for some of the ethnic variation in prostate cancer risk...
Premature menopause in a multi-ethnic population study of the menopause transitionJ L Luborsky
Departments of Obstetrics and Gynecology and Preventive Medicine, Rush Medical College, Chicago, IL, USA
Hum Reprod 18:199-206. 2003..Little information is available on the general prevalence of POF or on the prevalence by ethnic group. There is also a lack of information on the association of POF with health indicators...
Survival variability by race and ethnicity in childhood acute lymphoblastic leukemiaNina S Kadan-Lottick
Division of Pediatric Hematology/Oncology, Yale University, New Haven, Conn, USA
JAMA 290:2008-14. 2003..Future work must delineate the social and biological factors, including any differences in pharmacokinetics associated with chemotherapeutic agents, that account for disparities in outcome...
Utilization of health care resources by HIV-infected white, African-American, and Hispanic men in the era before highly active antiretroviral therapyTerri J Menke
Houston Center for Quality of Care and Utilization Studies, Health Services Research and Development Service, Department of Veterans Affairs Medical Center, 2002 Holcombe Boulevard, Houston, TX 77030, USA
J Natl Med Assoc 95:853-61. 2003..Undesirable resource utilization patterns by African-American and Hispanic populations need urgent attention...
Allele frequencies of tissue factor pathway inhibitor polymorphisms in African-American, Hispanic and Caucasian populationsGabriele I Mues
Thromb Haemost 88:875-7. 2002
Dental caries experience in northern Manhattan adolescentsDennis A Mitchell
Columbia University School of Dental and Oral Surgery, Division of Community Health, 630 West 168th Street, P and S Box 20, New York, NY 10032, USA
J Public Health Dent 63:189-94. 2003..The study sought to document dental caries among adolescents residing in northern Manhattan, New York, by race, sex, and community...
Rethinking individualism and collectivism: evaluation of theoretical assumptions and meta-analysesDaphna Oyserman
Department of Psychology, School of Social Work, University of Michigan, Ann Arbor 48106 1248, USA
Psychol Bull 128:3-72. 2002..Moderate IND-COL effects were found on self-concept and relationality, and large effects were found on attribution and cognitive style...
Usefulness of prior hysterectomy as an independent predictor of Framingham risk score (The Women's Health Initiative)Judith Hsia
George Washington University, Washington, DC 20037, USA
Am J Cardiol 92:264-9. 2003..04). In multivariate analysis, hysterectomy with bilateral oophorectomy was an independent predictor of Framingham risk (p = 0.04), whereas hysterectomy with ovarian preservation was not...
Research Grants
- Gene Networks for Prostate Cancer ProgressionLeif Peterson; Fiscal Year: 2005..Characterization of the FGFR1 and FGFR2 pathways in prostate cancer will contribute to the molecular understanding and early detection of patients that may experience rapid progression of metastases. ..
- Epidemiology of CHD of Men Aged 40+ in US, Hawaii, JapanAkira Sekikawa; Fiscal Year: 2010....
- Sources of Change and Stability in Low-Income Black MarriagesBENJAMIN KARNEY; Fiscal Year: 2009..These data will be combined with data from an ongoing study of low-income Hispanic newlyweds in order to identify the sources of differences in marital outcomes for these two similarly underprivileged groups ..
- Sources of Change and Stability in Low-Income Black MarriagesBENJAMIN REUVEN KARNEY; Fiscal Year: 2010..These data will be combined with data from an ongoing study of low-income Hispanic newlyweds in order to identify the sources of differences in marital outcomes for these two similarly underprivileged groups ..
- UNIVERSITY OF NEW MEXICO CANCER CENTER PLANNING GRANTCheryl Willman; Fiscal Year: 2004..abstract_text> ..
- HCV TREATMENT IN AFRICAN AMERICANS VS NON HISPANIC WHIT*Lennox Jeffers; Fiscal Year: 2004..SPECIFIC AIM 7. To identify sociodemographic (e.g., age, education income, gender, ethnicity) and psychosocial (e.g., anxiety, depression, coping) predictors of adherence to treatment and virologic response to HCV RNA. ..
- Disparities in cervical cancer precursors and deregulation of imprinted genesSusan Kay Murphy; Fiscal Year: 2010..Data from this study will elucidate the role of epigenetic deregulation in CIN2+ and inform triage decisions, reducing disparities in cervical cancer incidence and mortality. ..
- Promoting Walking in African Americans with Peripheral Arterial DiseaseTRACIE CHIANTI COLLINS; Fiscal Year: 2010....
- Ethnic Differences in Responses to Painful StimuliRoger Fillingim; Fiscal Year: 2009....
- Genotypes, Haplotypes, and Blood Pressure Change from Childhood to AdulthoodDAVID HALLMAN; Fiscal Year: 2009....
- Reducing disparities in colorectal cancer screening in Vietnamese AmericansBang Nguyen; Fiscal Year: 2009....
- VIRAHEP-C Clinical CenterAnna Lok; Fiscal Year: 2005..abstract_text> ..
- Reducing disparities in colorectal cancer screening in Vietnamese AmericansBang Nguyen; Fiscal Year: 2009..abstract_text> ..
- Dose-dependent anti-inflammatory effects of vitamin D in a human gingivitis modelRaul Garcia; Fiscal Year: 2007....
- PHARMACOKINETICS AND PHARMACODYNAMICS OF NICOTINENeal L Benowitz; Fiscal Year: 2010..An ultimate objective is to use this knowledge to aid in the development of more effective smoking cessation interventions for African-Americans. ..
- PHARMACOKINETICS AND PHARMACODYNAMICS OF NICOTINENeal Benowitz; Fiscal Year: 2009..An ultimate objective is to use this knowledge to aid in the development of more effective smoking cessation interventions for African-Americans. ..
- Disparities in CHD in the Jackson Heart StudyMario Sims; Fiscal Year: 2007..This research will also show which factors health policy makers need to focus on in order to address and eliminate CHD disparities. ..
- Resistance to Antiviral Therapy in Chronic Hepatitis CNorah Terrault; Fiscal Year: 2005..Moreover, the methodologies developed for patient outreach within the context of this collaborative study will serve as a model for enhancing participation of African Americans in clinical research. ..
- INCIDENCE OF DIABETES AND CVD IN MEXICAN AMERICANSMichael Stern; Fiscal Year: 2002..The investigators note that this will aid in the interpretation of data relating to possible ethnic differences in cause-specific mortality based on death certificate coding. ..
- Understanding Race and Culture in Living Donor Kidney TransplantationLarissa Myaskovsky; Fiscal Year: 2009..Findings from this study are needed in order to develop patient, provider, and system-level interventions to increase rates of LDKT and improve post-transplant health outcomes among African Americans. ..
- Using Doctor-Patient Teams to Reduce Health DisparitiesLouis Penner; Fiscal Year: 2007..If successful, the study should provide an exportable means of improving communication between physicians and minority group patients and reducing disparities in health care. ..
- Mexican-American Trial of Community Health Workers-MATCHSteven Rothschild; Fiscal Year: 2007..Future translation of this research will be facilitated by a well-standardized intervention and rigorous monitoring of CHW encounters through audiotapes and documentation of intervention worksheets. ..
- Characterizing Mitochondrial DNA Susceptibility to Breast, Colorectal, and ProstaIona Cheng; Fiscal Year: 2009..In addition, we will evaluate heterogeneity of effects by disease sub-groups, environmental factors and known genetic risk factors. ..
- Information and Financial Interventions for Kidney Donation in African AmericansLEIGH BOULWARE; Fiscal Year: 2009....
- Information and Financial Interventions for Kidney Donation in African AmericansLEIGH BOULWARE; Fiscal Year: 2009....
