aged

Summary

Summary: A person 65 through 79 years of age. For a person older than 79 years, AGED, 80 AND OVER is available.

Top Publications

  1. Finch A, Lubinski J, Møller P, Singer C, Karlan B, Senter L, et al. Impact of oophorectomy on cancer incidence and mortality in women with a BRCA1 or BRCA2 mutation. J Clin Oncol. 2014;32:1547-53 pubmed publisher
  2. Gunderson C, Java J, Moore K, Walker J. The impact of obesity on surgical staging, complications, and survival with uterine cancer: a Gynecologic Oncology Group LAP2 ancillary data study. Gynecol Oncol. 2014;133:23-7 pubmed publisher
    ..To determine the association of body mass index (BMI) on complications, recurrence, and survival in GOG LAP2, a randomized comparison of laparoscopic versus open staging in clinically early stage uterine cancer (EC)...
  3. Feld J, Kowdley K, Coakley E, Sigal S, Nelson D, Crawford D, et al. Treatment of HCV with ABT-450/r-ombitasvir and dasabuvir with ribavirin. N Engl J Med. 2014;370:1594-603 pubmed publisher
    ..In this phase 3 trial, we evaluated this regimen in previously untreated patients with HCV genotype 1 infection and no cirrhosis...
  4. Pujade Lauraine E, Hilpert F, Weber B, Reuss A, Poveda A, Kristensen G, et al. Bevacizumab combined with chemotherapy for platinum-resistant recurrent ovarian cancer: The AURELIA open-label randomized phase III trial. J Clin Oncol. 2014;32:1302-8 pubmed publisher
    ..Bevacizumab is active alone and in combination. AURELIA is the first randomized phase III trial to our knowledge combining bevacizumab with chemotherapy in platinum-resistant OC...
  5. Wang J, Ning X, Yang L, Tu J, Gu H, Zhan C, et al. Sex differences in trends of incidence and mortality of first-ever stroke in rural Tianjin, China, from 1992 to 2012. Stroke. 2014;45:1626-31 pubmed publisher
    ..These results suggest that stroke will become one of the major diseases affecting women in future decades in China. ..
  6. Asfar P, Meziani F, Hamel J, Grelon F, Megarbane B, Anguel N, et al. High versus low blood-pressure target in patients with septic shock. N Engl J Med. 2014;370:1583-93 pubmed publisher
    ..Funded by the French Ministry of Health; SEPSISPAM ClinicalTrials.gov number, NCT01149278.). ..
  7. Roumie C, Greevy R, Grijalva C, Hung A, Liu X, Murff H, et al. Association between intensification of metformin treatment with insulin vs sulfonylureas and cardiovascular events and all-cause mortality among patients with diabetes. JAMA. 2014;311:2288-96 pubmed publisher
    ..These findings require further investigation to understand risks associated with insulin use in these patients. ..
  8. Mozaffarian D, Fahimi S, Singh G, Micha R, Khatibzadeh S, Engell R, et al. Global sodium consumption and death from cardiovascular causes. N Engl J Med. 2014;371:624-34 pubmed publisher
    ..High sodium intake increases blood pressure, a risk factor for cardiovascular disease, but the effects of sodium intake on global cardiovascular mortality are uncertain...
  9. Tannenbaum C, Martin P, Tamblyn R, Benedetti A, Ahmed S. Reduction of inappropriate benzodiazepine prescriptions among older adults through direct patient education: the EMPOWER cluster randomized trial. JAMA Intern Med. 2014;174:890-8 pubmed publisher
    ..Participants (303 long-term users of benzodiazepine medication aged 65-95 years, recruited from 30 community pharmacies) were screened and enrolled prior to randomization: 15 ..

More Information

Publications74

  1. Dam T, Peters K, Fragala M, Cawthon P, Harris T, McLean R, et al. An evidence-based comparison of operational criteria for the presence of sarcopenia. J Gerontol A Biol Sci Med Sci. 2014;69:584-90 pubmed publisher
    ..Participants included in these analyses were aged 65 and older and had measures of body mass index, appendicular lean mass, grip strength, and gait speed...
  2. Rind E, Jones A, Southall H. How is post-industrial decline associated with the geography of physical activity? Evidence from the Health Survey for England. Soc Sci Med. 2014;104:88-97 pubmed publisher
    ..We conclude that post-industrial change may be a factor in explaining present-day variations in physical activity, emphasising the plausible impact of inherited cultures and regional identities on health related behaviours. ..
  3. Carvajal R, Sosman J, Quevedo J, Milhem M, Joshua A, Kudchadkar R, et al. Effect of selumetinib vs chemotherapy on progression-free survival in uveal melanoma: a randomized clinical trial. JAMA. 2014;311:2397-405 pubmed publisher
    ..Uveal melanoma is characterized by mutations in GNAQ and GNA11, resulting in mitogen-activated protein kinase pathway activation...
  4. Bill Axelson A, Holmberg L, Garmo H, Rider J, Taari K, Busch C, et al. Radical prostatectomy or watchful waiting in early prostate cancer. N Engl J Med. 2014;370:932-42 pubmed publisher
    ..Radical prostatectomy reduces mortality among men with localized prostate cancer; however, important questions regarding long-term benefit remain...
  5. Pearse R, Harrison D, MacDonald N, Gillies M, Blunt M, Ackland G, et al. Effect of a perioperative, cardiac output-guided hemodynamic therapy algorithm on outcomes following major gastrointestinal surgery: a randomized clinical trial and systematic review. JAMA. 2014;311:2181-90 pubmed publisher
    ..Small trials suggest that postoperative outcomes may be improved by the use of cardiac output monitoring to guide administration of intravenous fluid and inotropic drugs as part of a hemodynamic therapy algorithm...
  6. Jaraj D, Rabiei K, Marlow T, Jensen C, Skoog I, Wikkelsø C. Prevalence of idiopathic normal-pressure hydrocephalus. Neurology. 2014;82:1449-54 pubmed publisher
    ..We examined representative elderly populations aged 70 years and older that had undergone neuropsychiatric evaluations and CT of the brain between 1986 and 2000 (n = 1,..
  7. Reedy J, Krebs Smith S, Miller P, Liese A, Kahle L, Park Y, et al. Higher diet quality is associated with decreased risk of all-cause, cardiovascular disease, and cancer mortality among older adults. J Nutr. 2014;144:881-9 pubmed publisher
  8. Phoa K, van Vilsteren F, Weusten B, Bisschops R, Schoon E, Ragunath K, et al. Radiofrequency ablation vs endoscopic surveillance for patients with Barrett esophagus and low-grade dysplasia: a randomized clinical trial. JAMA. 2014;311:1209-17 pubmed publisher
    ..Barrett esophagus containing low-grade dysplasia is associated with an increased risk of developing esophageal adenocarcinoma, a cancer with a rapidly increasing incidence in the western world...
  9. Gianni L, Eiermann W, Semiglazov V, Lluch A, Tjulandin S, Zambetti M, et al. Neoadjuvant and adjuvant trastuzumab in patients with HER2-positive locally advanced breast cancer (NOAH): follow-up of a randomised controlled superiority trial with a parallel HER2-negative cohort. Lancet Oncol. 2014;15:640-7 pubmed publisher
  10. Midttun O, Townsend M, Nygård O, Tworoger S, Brennan P, Johansson M, et al. Most blood biomarkers related to vitamin status, one-carbon metabolism, and the kynurenine pathway show adequate preanalytical stability and within-person reproducibility to allow assessment of exposure or nutritional status in healthy women and card. J Nutr. 2014;144:784-90 pubmed publisher
    ..The Western Norway B Vitamin Intervention Trial was registered at clinicaltrials.gov as NTC00354081. ..
  11. Pencina M, Navar Boggan A, D Agostino R, Williams K, Neely B, Sniderman A, et al. Application of new cholesterol guidelines to a population-based sample. N Engl J Med. 2014;370:1422-31 pubmed publisher
    ..8 million, with the increase seen mostly among older adults without cardiovascular disease. (Funded by the Duke Clinical Research Institute and others.). ..
  12. Aiken L, Sloane D, Bruyneel L, Van den Heede K, Griffiths P, Busse R, et al. Nurse staffing and education and hospital mortality in nine European countries: a retrospective observational study. Lancet. 2014;383:1824-30 pubmed publisher
    ..For this observational study, we obtained discharge data for 422,730 patients aged 50 years or older who underwent common surgeries in 300 hospitals in nine European countries...
  13. Zeuzem S, Dusheiko G, Salupere R, Mangia A, Flisiak R, Hyland R, et al. Sofosbuvir and ribavirin in HCV genotypes 2 and 3. N Engl J Med. 2014;370:1993-2001 pubmed publisher
  14. King T, Bradford W, Castro Bernardini S, Fagan E, Glaspole I, Glassberg M, et al. A phase 3 trial of pirfenidone in patients with idiopathic pulmonary fibrosis. N Engl J Med. 2014;370:2083-92 pubmed publisher
    ..We sought to confirm the beneficial effect of pirfenidone on disease progression in such patients...
  15. Sartor O, Coleman R, Nilsson S, Heinrich D, Helle S, O Sullivan J, et al. Effect of radium-223 dichloride on symptomatic skeletal events in patients with castration-resistant prostate cancer and bone metastases: results from a phase 3, double-blind, randomised trial. Lancet Oncol. 2014;15:738-46 pubmed publisher
    ..We assessed the effect of radium-223 compared with placebo in patients with castration-resistant prostate cancer and bone metastases...
  16. Jørgensen A, Frikke Schmidt R, Nordestgaard B, Tybjærg Hansen A. Loss-of-function mutations in APOC3 and risk of ischemic vascular disease. N Engl J Med. 2014;371:32-41 pubmed publisher
    ..Whether lifelong low levels of nonfasting triglycerides owing to mutations in the gene encoding apolipoprotein C3 (APOC3) are associated with a reduced risk of ischemic cardiovascular disease in the general population is unknown...
  17. Altmann A, Tian L, Henderson V, Greicius M. Sex modifies the APOE-related risk of developing Alzheimer disease. Ann Neurol. 2014;75:563-73 pubmed publisher
    ..Biomarker results suggest that increased APOE-related risk in women may be associated with tau pathology. These findings have important clinical implications and suggest novel research approaches into AD pathogenesis. ..
  18. KROP I, Kim S, Gonzalez Martin A, LoRusso P, Ferrero J, Smitt M, et al. Trastuzumab emtansine versus treatment of physician's choice for pretreated HER2-positive advanced breast cancer (TH3RESA): a randomised, open-label, phase 3 trial. Lancet Oncol. 2014;15:689-99 pubmed publisher
    ..We aimed to compare trastuzumab emtansine, an antibody-drug conjugate comprising the cytotoxic agent DM1 linked to trastuzumab, with treatment of physician's choice in this population of patients...
  19. Xu J, Ou L. Resilience and quality of life among Wenchuan earthquake survivors: the mediating role of social support. Public Health. 2014;128:430-7 pubmed publisher
  20. Frei A, Muggensturm P, Putcha N, Siebeling L, Zoller M, Boyd C, et al. Five comorbidities reflected the health status in patients with chronic obstructive pulmonary disease: the newly developed COMCOLD index. J Clin Epidemiol. 2014;67:904-11 pubmed publisher
    ..It may help clinicians focus on comorbidities affecting patients' health status the most. ..
  21. Alley D, Shardell M, Peters K, McLean R, Dam T, Kenny A, et al. Grip strength cutpoints for the identification of clinically relevant weakness. J Gerontol A Biol Sci Med Sci. 2014;69:559-66 pubmed publisher
    ..8 m/s...
  22. Kawatsu Y, Kitada S, Uramoto H, Zhi L, Takeda T, Kimura T, et al. The combination of strong expression of ZNF143 and high MIB-1 labelling index independently predicts shorter disease-specific survival in lung adenocarcinoma. Br J Cancer. 2014;110:2583-92 pubmed publisher
    ..The combination of strong ZNF143 expression and high MIB-1 index potentially predicts high proliferating activity and poor prognosis in patients with lung adenocarcinoma, and may offer a therapeutic target against ZNF143. ..
  23. McLean R, Shardell M, Alley D, Cawthon P, Fragala M, Harris T, et al. Criteria for clinically relevant weakness and low lean mass and their longitudinal association with incident mobility impairment and mortality: the foundation for the National Institutes of Health (FNIH) sarcopenia project. J Gerontol A Biol Sci Med Sci. 2014;69:576-83 pubmed publisher
    ..8 m/s) and mortality. Providing validity for these criteria is essential for research and clinical evaluation...
  24. Robinson J, Nedergaard B, Rogers W, Fialkow J, Neutel J, Ramstad D, et al. Effect of evolocumab or ezetimibe added to moderate- or high-intensity statin therapy on LDL-C lowering in patients with hypercholesterolemia: the LAPLACE-2 randomized clinical trial. JAMA. 2014;311:1870-82 pubmed publisher
    ..Further studies are needed to evaluate the longer-term clinical outcomes and safety of this approach for LDL-C lowering. clinicaltrials.gov Identifier: NCT01763866. ..
  25. Sanna T, Diener H, Passman R, Di Lazzaro V, Bernstein R, Morillo C, et al. Cryptogenic stroke and underlying atrial fibrillation. N Engl J Med. 2014;370:2478-86 pubmed publisher
    ..3; 95% CI, 2.6 to 20.8; P<0.001). ECG monitoring with an ICM was superior to conventional follow-up for detecting atrial fibrillation after cryptogenic stroke. (Funded by Medtronic; CRYSTAL AF ClinicalTrials.gov number, NCT00924638.). ..
  26. Paton N, Kityo C, Hoppe A, Reid A, Kambugu A, Lugemwa A, et al. Assessment of second-line antiretroviral regimens for HIV therapy in Africa. N Engl J Med. 2014;371:234-47 pubmed publisher
    ..Removing the NRTIs or replacing them with raltegravir may provide a benefit...
  27. Kowdley K, Gordon S, Reddy K, Rossaro L, Bernstein D, Lawitz E, et al. Ledipasvir and sofosbuvir for 8 or 12 weeks for chronic HCV without cirrhosis. N Engl J Med. 2014;370:1879-88 pubmed publisher
    ..No additional benefit was associated with the inclusion of ribavirin in the regimen or with extension of the duration of treatment to 12 weeks. (Funded by Gilead Sciences; ION-3 ClinicalTrials.gov number, NCT01851330.). ..
  28. Cheng S, Wu Y, Yang M, Huang C, Huang H, Chu W, et al. Pulmonary rehabilitation improves heart rate variability at peak exercise, exercise capacity and health-related quality of life in chronic obstructive pulmonary disease. Heart Lung. 2014;43:249-55 pubmed publisher
    ..05). PR results in significant improvements in autonomic function, with concurrent improvements in HRQL and exercise capacity. ..
  29. Kavousi M, Leening M, Nanchen D, Greenland P, Graham I, Steyerberg E, et al. Comparison of application of the ACC/AHA guidelines, Adult Treatment Panel III guidelines, and European Society of Cardiology guidelines for cardiovascular disease prevention in a European cohort. JAMA. 2014;311:1416-23 pubmed publisher
    ..Panel III (ATP-III), and the European Society of Cardiology (ESC) guidelines using a cohort of Dutch individuals aged 55 years or older. We included 4854 Rotterdam Study participants recruited in 1997-2001...
  30. Chow E, Bernjak A, Williams S, Fawdry R, Hibbert S, Freeman J, et al. Risk of cardiac arrhythmias during hypoglycemia in patients with type 2 diabetes and cardiovascular risk. Diabetes. 2014;63:1738-47 pubmed publisher
    ..This is a plausible mechanism that could contribute to increased cardiovascular mortality during intensive glycemic therapy. ..
  31. Scarfone G, Bergamini A, Noli S, Villa A, Cipriani S, Taccagni G, et al. Characteristics of clear cell ovarian cancer arising from endometriosis: a two center cohort study. Gynecol Oncol. 2014;133:480-4 pubmed publisher
    ..We have investigated clinical and histological features of the largest published series of clear cell ovarian cancers arising in endometriosis using a retrospective database...
  32. Bhatt D, Kandzari D, O Neill W, D AGOSTINO R, Flack J, Katzen B, et al. A controlled trial of renal denervation for resistant hypertension. N Engl J Med. 2014;370:1393-401 pubmed publisher
    ..Funded by Medtronic; SYMPLICITY HTN-3 ClinicalTrials.gov number, NCT01418261.). ..
  33. Magill S, Edwards J, Bamberg W, Beldavs Z, Dumyati G, Kainer M, et al. Multistate point-prevalence survey of health care-associated infections. N Engl J Med. 2014;370:1198-208 pubmed publisher
    ..We conducted a prevalence survey in 10 geographically diverse states to determine the prevalence of health care-associated infections in acute care hospitals and generate updated estimates of the national burden of such infections...
  34. Amieva H, Mokri H, Le Goff M, Meillon C, Jacqmin Gadda H, Foubert Samier A, et al. Compensatory mechanisms in higher-educated subjects with Alzheimer's disease: a study of 20 years of cognitive decline. Brain. 2014;137:1167-75 pubmed publisher
    ..In contrast, higher education protects against further cognitive decline for ?7 years until pathology becomes more severe. ..
  35. Imperiale T, Ransohoff D, Itzkowitz S, Levin T, Lavin P, Lidgard G, et al. Multitarget stool DNA testing for colorectal-cancer screening. N Engl J Med. 2014;370:1287-97 pubmed publisher
    ..An accurate, noninvasive test could improve the effectiveness of colorectal-cancer screening...
  36. Olivot J, Mlynash M, Inoue M, Marks M, Wheeler H, Kemp S, et al. Hypoperfusion intensity ratio predicts infarct progression and functional outcome in the DEFUSE 2 Cohort. Stroke. 2014;45:1018-23 pubmed publisher
    ..4 (95% CI, 1.3-14.3); P=0.014. HIR can be easily assessed on automatically processed perfusion maps and predicts the rate of collateral flow, infarct growth, and clinical outcome. ..
  37. Di Angelantonio E, Gao P, Khan H, Butterworth A, Wormser D, Kaptoge S, et al. Glycated hemoglobin measurement and prediction of cardiovascular disease. JAMA. 2014;311:1225-33 pubmed publisher
    ..In a study of individuals without known CVD or diabetes, additional assessment of HbA1c values in the context of CVD risk assessment provided little incremental benefit for prediction of CVD risk. ..
  38. James B, Leurgans S, Hebert L, Scherr P, Yaffe K, Bennett D. Contribution of Alzheimer disease to mortality in the United States. Neurology. 2014;82:1045-50 pubmed publisher
    ..Data came from 2,566 persons aged 65 years and older (mean 78...
  39. Stevens J, Rudd R. Circumstances and contributing causes of fall deaths among persons aged 65 and older: United States, 2010. J Am Geriatr Soc. 2014;62:470-5 pubmed publisher
    To determine whether the increasing fall death rate among people aged 65 and older is due in part to temporal changes in recording the underlying cause of death...
  40. Qi Q, Chu A, Kang J, Huang J, Rose L, Jensen M, et al. Fried food consumption, genetic risk, and body mass index: gene-diet interaction analysis in three US cohort studies. BMJ. 2014;348:g1610 pubmed publisher
    ..To examine the interactions between genetic predisposition and consumption of fried food in relation to body mass index (BMI) and obesity...
  41. Caironi P, Tognoni G, Masson S, Fumagalli R, Pesenti A, Romero M, et al. Albumin replacement in patients with severe sepsis or septic shock. N Engl J Med. 2014;370:1412-21 pubmed publisher
    ..Funded by the Italian Medicines Agency; ALBIOS ClinicalTrials.gov number, NCT00707122.). ..
  42. Hussey P, Schneider E, Rudin R, Fox D, Lai J, Pollack C. Continuity and the costs of care for chronic disease. JAMA Intern Med. 2014;174:742-8 pubmed publisher
    ..Better continuity of care is expected to improve patient outcomes and reduce health care costs, but patterns of use, costs, and clinical complications associated with the current patterns of care continuity have not been quantified...
  43. Shinohara M, Fujioka S, Murray M, Wojtas A, Baker M, Rovelet Lecrux A, et al. Regional distribution of synaptic markers and APP correlate with distinct clinicopathological features in sporadic and familial Alzheimer's disease. Brain. 2014;137:1533-49 pubmed publisher
    ..Region-specific amyloid-??? accumulation might account for differences in the relative amounts of tau pathology and clinical symptoms in familial and sporadic Alzheimer's disease...
  44. Peters S, Huxley R, Woodward M. Diabetes as a risk factor for stroke in women compared with men: a systematic review and meta-analysis of 64 cohorts, including 775,385 individuals and 12,539 strokes. Lancet. 2014;383:1973-80 pubmed publisher
    ..These data add to the existing evidence that men and women experience diabetes-related diseases differently and suggest the need for further work to clarify the biological, behavioural, or social mechanisms involved. None. ..
  45. Gollub M, Grewal R, Panu N, Thipphavong S, Sohn M, Zheng J, et al. Diagnostic accuracy of ¹?F-FDG PET/CT for detection of advanced colorectal adenoma. Clin Radiol. 2014;69:611-8 pubmed publisher
    ..To determine the accuracy of 2-[(18)F]-fluoro-2-deoxy-d-glucose (FDG) positron-emission tomography (PET) in the detection of advanced colorectal adenomas...
  46. Antoniou A, Casadei S, Heikkinen T, Barrowdale D, Pylkäs K, Roberts J, et al. Breast-cancer risk in families with mutations in PALB2. N Engl J Med. 2014;371:497-506 pubmed publisher
    ..Germline loss-of-function mutations in PALB2 are known to confer a predisposition to breast cancer. However, the lifetime risk of breast cancer that is conferred by such mutations remains unknown...
  47. Ogden C, Carroll M, Kit B, Flegal K. Prevalence of childhood and adult obesity in the United States, 2011-2012. JAMA. 2014;311:806-14 pubmed publisher
    ..More than one-third of adults and 17% of youth in the United States are obese, although the prevalence remained stable between 2003-2004 and 2009-2010...
  48. Fonarow G, Zhao X, Smith E, Saver J, Reeves M, Bhatt D, et al. Door-to-needle times for tissue plasminogen activator administration and clinical outcomes in acute ischemic stroke before and after a quality improvement initiative. JAMA. 2014;311:1632-40 pubmed publisher
  49. Devereaux P, Mrkobrada M, Sessler D, Leslie K, Alonso Coello P, Kurz A, et al. Aspirin in patients undergoing noncardiac surgery. N Engl J Med. 2014;370:1494-503 pubmed publisher
    ..Funded by the Canadian Institutes of Health Research and others; POISE-2 ClinicalTrials.gov number, NCT01082874.). ..
  50. Pan C, Lin Y. Overweight, obesity, and age-related cataract: a meta-analysis. Optom Vis Sci. 2014;91:478-83 pubmed publisher
    ..To examine the longitudinal association of overweight/obesity with age-related cataract...
  51. Afdhal N, Reddy K, Nelson D, Lawitz E, Gordon S, Schiff E, et al. Ledipasvir and sofosbuvir for previously treated HCV genotype 1 infection. N Engl J Med. 2014;370:1483-93 pubmed publisher
    ..Effective treatment for hepatitis C virus (HCV) genotype 1 infection in patients who have not had a sustained virologic response to prior interferon-based therapy represents an unmet medical need...
  52. Fisher R, Acevedo C, Arzimanoglou A, Bogacz A, Cross J, Elger C, et al. ILAE official report: a practical clinical definition of epilepsy. Epilepsia. 2014;55:475-82 pubmed publisher
    ..This revised definition of epilepsy brings the term in concordance with common use. A PowerPoint slide summarizing this article is available for download in the Supporting Information section here. ..
  53. Kumarswamy R, Bauters C, Volkmann I, Maury F, Fetisch J, Holzmann A, et al. Circulating long noncoding RNA, LIPCAR, predicts survival in patients with heart failure. Circ Res. 2014;114:1569-75 pubmed publisher
    ..LIPCAR is a novel biomarker of cardiac remodeling and predicts future death in patients with heart failure. ..
  54. Studenski S, Peters K, Alley D, Cawthon P, McLean R, Harris T, et al. The FNIH sarcopenia project: rationale, study description, conference recommendations, and final estimates. J Gerontol A Biol Sci Med Sci. 2014;69:547-58 pubmed publisher
    ..512 for women. These evidence-based cutpoints, based on a large and diverse population, may help identify participants for clinical trials and should be evaluated among populations with high rates of functional limitations. ..
  55. Cawthon P, Peters K, Shardell M, McLean R, Dam T, Kenny A, et al. Cutpoints for low appendicular lean mass that identify older adults with clinically significant weakness. J Gerontol A Biol Sci Med Sci. 2014;69:567-75 pubmed publisher
  56. Kitzman D, Nicklas B, Kraus W, Lyles M, Eggebeen J, Morgan T, et al. Skeletal muscle abnormalities and exercise intolerance in older patients with heart failure and preserved ejection fraction. Am J Physiol Heart Circ Physiol. 2014;306:H1364-70 pubmed publisher
    ..This suggests potential new therapeutic targets in this difficult to treat disorder. ..
  57. Mapstone M, Cheema A, Fiandaca M, Zhong X, Mhyre T, MacArthur L, et al. Plasma phospholipids identify antecedent memory impairment in older adults. Nat Med. 2014;20:415-8 pubmed publisher
    ..This biomarker panel, reflecting cell membrane integrity, may be sensitive to early neurodegeneration of preclinical Alzheimer's disease. ..
  58. Kris M, Johnson B, Berry L, Kwiatkowski D, Iafrate A, Wistuba I, et al. Using multiplexed assays of oncogenic drivers in lung cancers to select targeted drugs. JAMA. 2014;311:1998-2006 pubmed publisher
    ..The Lung Cancer Mutation Consortium was formed to perform multiplexed assays testing adenocarcinomas of the lung for drivers in 10 genes to enable clinicians to select targeted treatments and enroll patients into clinical trials...
  59. Rapsomaniki E, Timmis A, George J, Pujades Rodriguez M, Shah A, Denaxas S, et al. Blood pressure and incidence of twelve cardiovascular diseases: lifetime risks, healthy life-years lost, and age-specific associations in 1·25 million people. Lancet. 2014;383:1899-911 pubmed publisher
    ..These findings emphasise the need for new blood pressure-lowering strategies, and will help to inform the design of randomised trials to assess them. Medical Research Council, National Institute for Health Research, and Wellcome Trust. ..
  60. Sánchez Espiridión B, Chen M, Chang J, Lu C, Chang D, Roth J, et al. Telomere length in peripheral blood leukocytes and lung cancer risk: a large case-control study in Caucasians. Cancer Res. 2014;74:2476-86 pubmed publisher
    ..In contrast, long telomeres were protective against SCC, particularly in male patients. Our results extend the concept that telomere length affects risk of lung cancer in a manner that differs with histologic subtype...
  61. Yau T, Tang V, Yao T, Fan S, Lo C, Poon R. Development of Hong Kong Liver Cancer staging system with treatment stratification for patients with hepatocellular carcinoma. Gastroenterology. 2014;146:1691-700.e3 pubmed publisher
    ..The HKLC system should be validated in non-Asian patient populations and in patients with different etiologies of HCC. ..
  62. Afdhal N, Zeuzem S, Kwo P, Chojkier M, Gitlin N, Puoti M, et al. Ledipasvir and sofosbuvir for untreated HCV genotype 1 infection. N Engl J Med. 2014;370:1889-98 pubmed publisher
  63. Ye Z, Altena E, Nombela C, Housden C, Maxwell H, Rittman T, et al. Selective serotonin reuptake inhibition modulates response inhibition in Parkinson's disease. Brain. 2014;137:1145-55 pubmed publisher
  64. Wardlaw J, Allerhand M, Doubal F, Valdes Hernandez M, Morris Z, Gow A, et al. Vascular risk factors, large-artery atheroma, and brain white matter hyperintensities. Neurology. 2014;82:1331-8 pubmed publisher
    ..VRF modification, although important, may be limited in preventing WMH and their stroke and dementia consequences. Investigation of, and interventions against, other suspected small-vessel disease mechanisms should be addressed. ..
  65. Muntner P, Colantonio L, Cushman M, Goff D, Howard G, Howard V, et al. Validation of the atherosclerotic cardiovascular disease Pooled Cohort risk equations. JAMA. 2014;311:1406-15 pubmed publisher
    ..Adults aged 45 to 79 years enrolled in the Reasons for Geographic and Racial Differences in Stroke (REGARDS) study between ..