peroxiredoxins

Summary

Summary: A family of ubiquitously-expressed peroxidases that play a role in the reduction of a broad spectrum of PEROXIDES like HYDROGEN PEROXIDE; LIPID PEROXIDES and peroxinitrite. They are found in a wide range of organisms, such as BACTERIA; PLANTS; and MAMMALS. The enzyme requires the presence of a thiol-containing intermediate such as THIOREDOXIN as a reducing cofactor.

Top Publications

  1. Rinder H, Thomschke A, Rusch Gerdes S, Bretzel G, Feldmann K, Rifai M, et al. Significance of ahpC promoter mutations for the prediction of isoniazid resistance in Mycobacterium tuberculosis. Eur J Clin Microbiol Infect Dis. 1998;17:508-11 pubmed
  2. Gong F, Wang J, Li J. Isolation and characterization of peroxiredoxin 1 gene of Dunaliella salina. Gene. 2017;635:39-45 pubmed publisher
    ..Taken together, DsPrdx1 not only participates in flagellar disassembly, but also protects RNA from degradation. ..
  3. Lu W, Fu Z, Wang H, Feng J, Wei J, Guo J. Peroxiredoxin 2 is upregulated in colorectal cancer and contributes to colorectal cancer cells' survival by protecting cells from oxidative stress. Mol Cell Biochem. 2014;387:261-70 pubmed
    ..Our results suggested that Prdx2 has an essential role in regulating oxidation-induced apoptosis in CRC cells. Prdx2 may have potential as a therapeutic target in CRC. ..
  4. Yang Y, Li X, Peng L, An L, Sun N, Hu X, et al. Tanshindiol C inhibits oxidized low-density lipoprotein induced macrophage foam cell formation via a peroxiredoxin 1 dependent pathway. Biochim Biophys Acta Mol Basis Dis. 2018;1864:882-890 pubmed publisher
    ..These observations suggest that Tan C protects macrophages from oxLDL induced foam cell formation via activation of Prdx1/ABCA1 signaling and that Prdx1 may be a novel target for therapeutic intervention of atherosclerosis. ..
  5. Garcia Bonilla L, Iadecola C. Peroxiredoxin sets the brain on fire after stroke. Nat Med. 2012;18:858-9 pubmed publisher
  6. Jelcic M, Enyedi B, Xavier J, Niethammer P. Image-Based Measurement of H2O2 Reaction-Diffusion in Wounded Zebrafish Larvae. Biophys J. 2017;112:2011-2018 pubmed publisher
    ..Thus, Duox-mediated long-range signaling may require other spatial relay mechanisms besides extracellular H2O2 diffusion. ..
  7. Hood K, Mair K, Harvey A, Montezano A, Touyz R, MacLean M. Serotonin Signaling Through the 5-HT1B Receptor and NADPH Oxidase 1 in Pulmonary Arterial Hypertension. Arterioscler Thromb Vasc Biol. 2017;37:1361-1370 pubmed publisher
    ..Our results suggest that 5-HT1B receptor-dependent cellular Src-related kinase-Nox1-pathways contribute to vascular remodeling in PAH. ..
  8. Gümbel D, Gelbrich N, Napp M, Daeschlein G, Kramer A, Sckell A, et al. Peroxiredoxin Expression of Human Osteosarcoma Cells Is Influenced by Cold Atmospheric Plasma Treatment. Anticancer Res. 2017;37:1031-1038 pubmed
    ..Antioxidant supplementation with NAC increases proliferation of CAP-treated osteosarcoma cells, implicating an involvement of redox signalling. Activation of PRX1 and -2 indicate CAP affects redox homeostasis. ..
  9. Pinna S, Pasella S, Deiana M, Baralla A, Mannu A, Masala A, et al. Proteomic analysis of human plasma and peripheral blood mononuclear cells in Systemic Lupus Erythematosus patients. J Immunol Methods. 2017;446:37-46 pubmed publisher
    ..These proteomic results provide suggestions for understanding the molecular mechanisms of SLE, as well as the physiological changes correlated with SLE disease. ..

More Information

Publications30

  1. Visiedo F, Santos Rosendo C, Mateos Bernal R, Gil Sánchez M, Bugatto F, Aguilar Diosdado M, et al. Characterization of NO-Induced Nitrosative Status in Human Placenta from Pregnant Women with Gestational Diabetes Mellitus. Oxid Med Cell Longev. 2017;2017:5629341 pubmed publisher
  2. Jeon H, Park Y, Cho D, Kim J, Kim E, Chae H, et al. Peroxiredoxins are required for spindle assembly, chromosome organization, and polarization in mouse oocytes. Biochem Biophys Res Commun. 2017;489:193-199 pubmed publisher
    b>Peroxiredoxins (Prxs) are highly conserved antioxidant enzymes and are implicated in multiple biological processes; however, their function in oocyte meiosis has not been studied...
  3. Shichita T, Ito M, Morita R, Komai K, Noguchi Y, Ooboshi H, et al. MAFB prevents excess inflammation after ischemic stroke by accelerating clearance of damage signals through MSR1. Nat Med. 2017;23:723-732 pubmed publisher
    ..In this study, we demonstrate that common DAMPs, such as high-mobility-group box 1 (HMGB1), peroxiredoxins (PRXs), and S100A8 and S100A9, were internalized through the class A scavenger receptors MSR1 and MARCO in ..
  4. Ishii T, Itoh K, Takahashi S, Sato H, Yanagawa T, Katoh Y, et al. Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophages. J Biol Chem. 2000;275:16023-9 pubmed
    ..Several stress agents induced the DNA binding activity of Nrf2 in the nucleus without increasing its mRNA level. Thus Nrf2 regulates a wide-ranging metabolic response to oxidative stress. ..
  5. Banerjee M, Chakravarty D, Ballal A. Redox-dependent chaperone/peroxidase function of 2-Cys-Prx from the cyanobacterium Anabaena PCC7120: role in oxidative stress tolerance. BMC Plant Biol. 2015;15:60 pubmed publisher
    ..nitrogen-fixing cyanobacterium Anabaena PCC7120 harbours a single gene (alr4641) encoding a typical 2-Cys-Peroxiredoxins (2-Cys-Prxs)...
  6. Conway M, Lee C. The redox switch that regulates molecular chaperones. Biomol Concepts. 2015;6:269-84 pubmed publisher
  7. Rhee S, Kil I. Multiple Functions and Regulation of Mammalian Peroxiredoxins. Annu Rev Biochem. 2017;86:749-775 pubmed publisher
    b>Peroxiredoxins (Prxs) constitute a major family of peroxidases, with mammalian cells expressing six Prx isoforms (PrxI to PrxVI)...
  8. Kumar A, Nartey W, Shin J, Manimekalai M, Gruber G. Structural and mechanistic insights into Mycothiol Disulphide Reductase and the Mycoredoxin-1-alkylhydroperoxide reductase E assembly of Mycobacterium tuberculosis. Biochim Biophys Acta Gen Subj. 2017;1861:2354-2366 pubmed publisher
    ..tuberculosis. ..
  9. Heym B, Stavropoulos E, Honore N, Domenech P, Saint Joanis B, Wilson T, et al. Effects of overexpression of the alkyl hydroperoxide reductase AhpC on the virulence and isoniazid resistance of Mycobacterium tuberculosis. Infect Immun. 1997;65:1395-401 pubmed
  10. Lee S, Jeong H, Lee J, Chung J, Kim R, Yun H, et al. Characterisation of conformational and functional features of alkyl hydroperoxide reductase E-like protein. Biochem Biophys Res Commun. 2017;489:217-222 pubmed publisher
    ..Based on our results, we provided that TkAhpE is a multifunctional peroxidase displaying structure-dependent molecular chaperone and DNA binding activities. ..
  11. Slade L, Chalker J, Kuksal N, Young A, Gardiner D, Mailloux R. Examination of the superoxide/hydrogen peroxide forming and quenching potential of mouse liver mitochondria. Biochim Biophys Acta Gen Subj. 2017;1861:1960-1969 pubmed publisher
    ..We also confirm that catalase plays a role in quenching either exogenous or intramitochondrial H2O2. ..
  12. Fereig R, Kuroda Y, Terkawi M, Mahmoud M, Nishikawa Y. Immunization with Toxoplasma gondii peroxiredoxin 1 induces protective immunity against toxoplasmosis in mice. PLoS ONE. 2017;12:e0176324 pubmed publisher
    ..gondii infection. Thus, our results suggest that TgPrx1 efficiently induces humoral and cellular immune responses and is useful as a new vaccine antigen against toxoplasmosis. ..
  13. Ahn H, Yoo J, Lee S, Lee H, Lee H, Lee D. Peroxiredoxin 5 promotes the epithelial-mesenchymal transition in colon cancer. Biochem Biophys Res Commun. 2017;487:580-586 pubmed publisher
    ..Therefore, PRX5 can be used as a predictive biomarker and serves as a putative therapeutic target for the development of clinical treatments for human CRC. ..
  14. Carvalho L, Truzzi D, Fallani T, Alves S, Toledo J, Augusto O, et al. Urate hydroperoxide oxidizes human peroxiredoxin 1 and peroxiredoxin 2. J Biol Chem. 2017;292:8705-8715 pubmed publisher
    ..glutathione and sulfur-containing amino acids and is expected to react fast toward reactive thiols from peroxiredoxins (Prxs)...
  15. Liao J, Wang K, Yao W, Yi X, Yan H, Chen M, et al. Cloning, expression and antioxidant activity of a thioredoxin peroxidase from Branchiostoma belcheri tsingtaunese. PLoS ONE. 2017;12:e0175162 pubmed publisher
    b>Peroxiredoxins (Prxs) are ubiquitous antioxidant enzymes that catalyze the thioredoxin- dependent reduction of hydroperoxides...
  16. Sperandio M, Demasi A, Martinez E, Saad S, Pericole F, Vieira K, et al. 15d-PGJ2 as an endoplasmic reticulum stress manipulator in multiple myeloma in vitro and in vivo. Exp Mol Pathol. 2017;102:434-445 pubmed publisher
    ..Oxidized glutathione levels were also increased. 15d-PGJ2 at 4mg/kg in vivo halted tumour growth. In conclusion, 15d-PGJ2 induced myeloma cell death via ER stress in vitro. 15d-PGJ2 in vivo also inhibited tumour growth. ..
  17. Shi G, Zhou W, Li M, Ren F, Han Y. Characterization and Expression Analysis of Peroxiredoxin Genes in NNK-induced V79 Cells. Biomed Environ Sci. 2017;30:224-228 pubmed publisher
    ..42-fold relative to that of the control. NNK induced alterations in Prx expression over the course of lung cancer, which means Prxs may play important roles in ROS detoxification under NNK stress and their functions are complementary...
  18. Kim K, Kim I, Lee K, Rhee S, Stadtman E. The isolation and purification of a specific "protector" protein which inhibits enzyme inactivation by a thiol/Fe(III)/O2 mixed-function oxidation system. J Biol Chem. 1988;263:4704-11 pubmed
    ..Since the protection activity reported herein is specific for mixed-function oxidation systems containing thiols, we propose that the protector protein functions as a sulfur radical scavenger. ..
  19. Boronat S, Domènech A, Carmona M, García Santamarina S, Bañó M, Ayte J, et al. Lack of a peroxiredoxin suppresses the lethality of cells devoid of electron donors by channelling electrons to oxidized ribonucleotide reductase. PLoS Genet. 2017;13:e1006858 pubmed publisher
    ..intramolecular disulfide bond formation as part of their catalytic cycles such as the peroxide scavengers peroxiredoxins or the enzyme ribonucleotide reductase (RNR)...
  20. Kang D, Lee D, Lee S, Lee S, Jun Y, Kim Y, et al. Interaction of tankyrase and peroxiredoxin II is indispensable for the survival of colorectal cancer cells. Nat Commun. 2017;8:40 pubmed publisher
    ..Here the authors show that in colorectal cancers with APC mutation, PrxII binds to tankyrase and prevents its oxidative inactivation, thereby preventing Axin1-dependent degradation of ²b-catenin. ..
  21. Voigt D, Scheidt U, Derfuss T, Bruck W, Junker A. Expression of the Antioxidative Enzyme Peroxiredoxin 2 in Multiple Sclerosis Lesions in Relation to Inflammation. Int J Mol Sci. 2017;18: pubmed publisher
    ..As an important scavenging enzyme family, peroxiredoxins (PRDXs) play a crucial role in preventing oxidative damage; however little is known about their expression and ..