schistosomiasis mansoni

Summary

Summary: Schistosomiasis caused by Schistosoma mansoni. It is endemic in Africa, the Middle East, South America, and the Caribbean and affects mainly the bowel, spleen, and liver.

Top Publications

  1. Wilson M, Cheever A, White S, Thompson R, Wynn T. IL-10 blocks the development of resistance to re-infection with Schistosoma mansoni. PLoS Pathog. 2011;7:e1002171 pubmed publisher
    ..This study demonstrates that blocking IL-10 signalling during PZQ treatment can facilitate the development of protective immunity and provide a highly effective strategy to protect against reinfection with S. mansoni. ..
  2. Mantawy M, Ali H, Rizk M. Therapeutic effects of Allium sativum and Allium cepa in Schistosoma mansoni experimental infection. Rev Inst Med Trop Sao Paulo. 2011;53:155-63 pubmed
    ..mansoni infected mice after administration of the studied extracts. Moreover a significant reduction in worm burden, hepatic and intestinal eggs and oogram count was noticed which was reflected in normalization of liver architecture. ..
  3. Sousa Figueiredo J, Betson M, Kabatereine N, Stothard J. The urine circulating cathodic antigen (CCA) dipstick: a valid substitute for microscopy for mapping and point-of-care diagnosis of intestinal schistosomiasis. PLoS Negl Trop Dis. 2013;7:e2008 pubmed publisher
    ..The diagnostic performance of this test was not significantly impacted by treatment history or co-infections with other intestinal helminths. ..
  4. Levitz S, Standley C, Adriko M, Kabatereine N, Stothard J. Environmental epidemiology of intestinal schistosomiasis and genetic diversity of Schistosoma mansoni infections in snails at Bugoigo village, Lake Albert. Acta Trop. 2013;128:284-91 pubmed publisher
  5. Abou El Naga I, El Nassery S, Allam S, Shaat E, Mady R. Biomphalaria species in Alexandria water channels. Parasitol Int. 2011;60:247-54 pubmed publisher
    ..The results demonstrated that if Biomphalaria glabrata was reintroduced and adapted to the local environment in Egypt, it would have important epidemiologic impacts that would have a serious effect on the health of Egyptian people...
  6. Baeza Garcia A, Pierce R, Gourbal B, Werkmeister E, Colinet D, Reichhart J, et al. Involvement of the cytokine MIF in the snail host immune response to the parasite Schistosoma mansoni. PLoS Pathog. 2010;6:e1001115 pubmed publisher
    ..These results provide the first functional evidence that a MIF ortholog is involved in an invertebrate immune response towards a parasitic infection and highlight the importance of cytokines in invertebrate-parasite interactions...
  7. Teixeira de Melo T, Michel de Araujo J, Do Valle Durães F, Caliari M, Oliveira S, Coelho P, et al. Immunization with newly transformed Schistosoma mansoni schistosomula tegument elicits tegument damage, reduction in egg and parasite burden. Parasite Immunol. 2010;32:749-59 pubmed publisher
    ..Lastly, during an in vitro study, worms from mice immunized with Smteg showed damage in the adult worm tegument and impaired egg laying. ..
  8. Balog C, Meissner A, Goraler S, Bladergroen M, Vennervald B, Mayboroda O, et al. Metabonomic investigation of human Schistosoma mansoni infection. Mol Biosyst. 2011;7:1473-80 pubmed publisher
    ..These findings are in agreement with data from earlier studies on S. mansoni infection in experimental animals and thus provide corroborating evidence for the existence of metabolic response specific for this infection. ..
  9. Parker Manuel S, Ivens A, Dillon G, Wilson R. Gene expression patterns in larval Schistosoma mansoni associated with infection of the mammalian host. PLoS Negl Trop Dis. 2011;5:e1274 pubmed publisher
    ..Patterns of gene expression underlying this transition have been characterised...

More Information

Publications78

  1. Barbosa C, Araújo K, Sevilla M, Melo F, Gomes E, Souza Santos R. Current epidemiological status of schistosomiasis in the state of Pernambuco, Brazil. Mem Inst Oswaldo Cruz. 2010;105:549-54 pubmed
  2. Neves J, de Lima M, Pereira V, de Melo C, Peixoto C, Pitta I, et al. Antischistosomal action of thioxo-imidazolidine compounds: an ultrastructural and cytotoxicity study. Exp Parasitol. 2011;128:82-90 pubmed publisher
    ..Thus, it is possible that these imidazolidine derivatives can be future candidates as schistosomotic drugs, but further studies are needed to elucidate the induced mechanisms behind this response. ..
  3. Enk M, Oliveira E Silva G, Rodrigues N. Diagnostic accuracy and applicability of a PCR system for the detection of Schistosoma mansoni DNA in human urine samples from an endemic area. PLoS ONE. 2012;7:e38947 pubmed publisher
    ..Furthermore the principals of this molecular technique, based on the examination of human urine samples may be useful for the diagnosis of other neglected tropical diseases that can be detected by trans-renal DNA. ..
  4. Bligh J, Schramm G, Chiodini P, Doenhoff M. Serological analysis of the outcome of treatment of Schistosoma mansoni infections with praziquantel. Ann Trop Med Parasitol. 2010;104:511-20 pubmed publisher
  5. Cook P, Aynsley S, Turner J, Jenkins G, Van Rooijen N, Leeto M, et al. Multiple helminth infection of the skin causes lymphocyte hypo-responsiveness mediated by Th2 conditioning of dermal myeloid cells. PLoS Pathog. 2011;7:e1001323 pubmed publisher
  6. Torben W, Ahmad G, Zhang W, Nash S, Le L, Karmakar S, et al. Role of antibody dependent cell mediated cytotoxicity (ADCC) in Sm-p80-mediated protection against Schistosoma mansoni. Vaccine. 2012;30:6753-8 pubmed publisher
  7. Grant A, Araujo M, Ponte E, Oliveira R, Cruz A, Barnes K, et al. Polymorphisms in IL10 are associated with total Immunoglobulin E levels and Schistosoma mansoni infection intensity in a Brazilian population. Genes Immun. 2011;12:46-50 pubmed publisher
    ..The tagging SNP rs3024495 was associated with high S. mansoni egg counts (P=0.005), suggesting a novel locus in IL10 may influence clinically relevant burden of infection. ..
  8. Avula L, Buckinx R, Alpaerts K, Costagliola A, Adriaensen D, Van Nassauw L, et al. The effect of inflammation on the expression and distribution of the MAS-related gene receptors MrgE and MrgF in the murine ileum. Histochem Cell Biol. 2011;136:569-85 pubmed publisher
    ..This is the first report on the expression of MrgE and MrgF in the ENS in (patho)physiological conditions. The expression of MrgE and MrgF in enteric neurons was negatively affected by inflammation...
  9. Fitzsimmons C, Jones F, Pinot de Moira A, Protasio A, Khalife J, Dickinson H, et al. Progressive cross-reactivity in IgE responses: an explanation for the slow development of human immunity to schistosomiasis?. Infect Immun. 2012;80:4264-70 pubmed publisher
    ..g., TAL3) and that this leads to increasing cross-reactivity with antigens of invading larvae (e.g., TAL5). Progressive accumulation of worm/larvae cross-reactivity could explain the age-dependent immunity observed in areas of endemicity...
  10. Bin Dajem S, Ibrahim E, Al Quraishy S, Mostafa O. Fingerprint of Biomphalaria arabica, the intermediate host of Schistosoma mansoni in Saudi Arabia, using RAPD-PCR. Gene. 2011;485:69-72 pubmed publisher
    ..arabica. This information will be helpful in the identification of the snails and demonstrating that RAPD-PCR is an appropriate and efficient methodological approach for establishment of genetic barcode development...
  11. Olliaro P, Vaillant M, Belizario V, Lwambo N, Ouldabdallahi M, Pieri O, et al. A multicentre randomized controlled trial of the efficacy and safety of single-dose praziquantel at 40 mg/kg vs. 60 mg/kg for treating intestinal schistosomiasis in the Philippines, Mauritania, Tanzania and Brazil. PLoS Negl Trop Dis. 2011;5:e1165 pubmed publisher
    ..Praziquantel at 40 mg/kg in a single dose is the WHO recommended treatment for all forms of schistosomiasis, but 60 mg/kg is also deployed nationally...
  12. Botros S, El Lakkany N, Seif El Din S, Sabra A, Ibrahim M. Comparative efficacy and bioavailability of different praziquantel brands. Exp Parasitol. 2011;127:515-21 pubmed publisher
    ..Quality of generic PZQ should include, in addition to examining the physicochemical characteristics of the brands, biological testing including efficacy and bioavailability studies...
  13. Betson M, Sousa Figueiredo J, Rowell C, Kabatereine N, Stothard J. Intestinal schistosomiasis in mothers and young children in Uganda: investigation of field-applicable markers of bowel morbidity. Am J Trop Med Hyg. 2010;83:1048-55 pubmed publisher
    ..0001) and mothers (n = 448, OR = 1.95, P = 0.004). Fecal occult blood appears to be useful for measuring morbidity associated with intestinal schistosomiasis and could be used in assessing the impact of control programs upon disease...
  14. Namwanje H, Kabatereine N, Olsen A. The acceptability and safety of praziquantel alone and in combination with mebendazole in the treatment of Schistosoma mansoni and soil-transmitted helminthiasis in children aged 1-4 years in Uganda. Parasitology. 2011;138:1586-92 pubmed publisher
  15. Elhag S, Abdelkareem E, Yousif A, Frah E, Mohamed A. Detection of schistosomiasis antibodies in urine patients as a promising diagnostic maker. Asian Pac J Trop Med. 2011;4:773-7 pubmed publisher
    ..Statistically no significant difference between the IgG levels in serum and urine samples was observed. This study shows that the detection of secreted IgG antibodies in urine can substitute serum for diagnosis of schistosomiasis. ..
  16. Coulibaly J, Knopp S, N Guessan N, Silué K, Fürst T, Lohourignon L, et al. Accuracy of urine circulating cathodic antigen (CCA) test for Schistosoma mansoni diagnosis in different settings of Côte d'Ivoire. PLoS Negl Trop Dis. 2011;5:e1384 pubmed publisher
    ..We assessed the accuracy of a commercially available CCA cassette test (designated CCA-A) and an experimental formulation (CCA-B) for S. mansoni diagnosis...
  17. Standley C, Mugisha L, Verweij J, Adriko M, Arinaitwe M, Rowell C, et al. Confirmed infection with intestinal schistosomiasis in semi-captive wild-born chimpanzees on Ngamba Island, Uganda. Vector Borne Zoonotic Dis. 2011;11:169-76 pubmed publisher
    ..However, nonhuman primates have recently been overlooked as potential hosts of the disease, despite known susceptibility...
  18. el Lakkany N, el Din S, Sabra A, Hammam O. Pharmacodynamics of mefloquine and praziquantel combination therapy in mice harbouring juvenile and adult Schistosoma mansoni. Mem Inst Oswaldo Cruz. 2011;106:814-22 pubmed
    ..Therefore, the use of Mef with PZQ is more effective than PZQ alone and should be considered for clinical trials in humans as a potential treatment regimen to prevent treatment failures in areas with high rates of schistosomiasis...
  19. Navaratnam A, Sousa Figueiredo J, Stothard J, Kabatereine N, Fenwick A, Mutumba Nakalembe M. Efficacy of praziquantel syrup versus crushed praziquantel tablets in the treatment of intestinal schistosomiasis in Ugandan preschool children, with observation on compliance and safety. Trans R Soc Trop Med Hyg. 2012;106:400-7 pubmed publisher
    ..1%) and crushed PZQ tablet (14.7%) arms. PZQ syrup and crushed PZQ tablets have very similar efficacies in the treatment of intestinal schistosomiasis in preschool children...
  20. El Ridi R, Tallima H. Vaccine-induced protection against murine schistosomiasis mansoni with larval excretory-secretory antigens and papain or type-2 cytokines. J Parasitol. 2013;99:194-202 pubmed publisher
    ..Improvement of ESP selection, singly or in a combination, and immunization regimen, namely ESP and type-2 cytokine dose and injection site and schedule, could lead to a sterilizing schistosomiasis vaccine in the foreseeable future...
  21. Sousa Figueiredo J, Betson M, Atuhaire A, Arinaitwe M, Navaratnam A, Kabatereine N, et al. Performance and safety of praziquantel for treatment of intestinal schistosomiasis in infants and preschool children. PLoS Negl Trop Dis. 2012;6:e1864 pubmed publisher
    ..We have formally assessed parasitological cure and putative side-effects in a prospective cohort of Schistosoma mansoni-infected children (aged 5 months-7 years old) in lakeshore settings of Uganda...
  22. Pereira T, Xie G, Choi S, Syn W, Voieta I, Lu J, et al. Macrophage-derived Hedgehog ligands promotes fibrogenic and angiogenic responses in human schistosomiasis mansoni. Liver Int. 2013;33:149-61 pubmed publisher
    b>Schistosomiasis mansoni is a major cause of portal fibrosis and portal hypertension. The Hedgehog pathway regulates fibrogenic repair in some types of liver injury.
  23. Hotez P, Bethony J, Diemert D, Pearson M, Loukas A. Developing vaccines to combat hookworm infection and intestinal schistosomiasis. Nat Rev Microbiol. 2010;8:814-26 pubmed publisher
    ..New genomic, proteomic, immunological and X-ray crystallographic data have led to the discovery of several promising candidate vaccine antigens. Here, we describe recent progress in this field and the rationale for vaccine development...
  24. Seto E, Sousa Figueiredo J, Betson M, Byalero C, Kabatereine N, Stothard J. Patterns of intestinal schistosomiasis among mothers and young children from Lake Albert, Uganda: water contact and social networks inferred from wearable global positioning system dataloggers. Geospat Health. 2012;7:1-13 pubmed
    ..We believe that this should now be formally considered within NCP, which may benefit from more in-depth ethnographic exploration of factors related to water contact as this should provide new opportunities for sustaining control...
  25. Farias L, Tararam C, Miyasato P, Nishiyama M, Oliveira K, Kawano T, et al. Screening the Schistosoma mansoni transcriptome for genes differentially expressed in the schistosomulum stage in search for vaccine candidates. Parasitol Res. 2011;108:123-35 pubmed publisher
  26. French M, Churcher T, Basanez M, Norton A, Lwambo N, Webster J. Reductions in genetic diversity of Schistosoma mansoni populations under chemotherapeutic pressure: the effect of sampling approach and parasite population definition. Acta Trop. 2013;128:196-205 pubmed publisher
  27. Fairfax K, Amiel E, King I, Freitas T, Mohrs M, Pearce E. IL-10R blockade during chronic schistosomiasis mansoni results in the loss of B cells from the liver and the development of severe pulmonary disease. PLoS Pathog. 2012;8:e1002490 pubmed publisher
    ..In summary, our data describe a role for IL-10-dependent B cell responses in the regulation of tissue damage during a chronic helminth infection...
  28. Bhardwaj R, Krautz Peterson G, Da dara A, Tzipori S, Skelly P. Tegumental phosphodiesterase SmNPP-5 is a virulence factor for schistosomes. Infect Immun. 2011;79:4276-84 pubmed publisher
    ..These results demonstrate that SmNPP-5 is a virulence factor for schistosomes...
  29. Siqueira L, Coelho P, Oliveira A, Massara C, Carneiro N, Lima A, et al. Evaluation of two coproscopic techniques for the diagnosis of schistosomiasis in a low-transmission area in the state of Minas Gerais, Brazil. Mem Inst Oswaldo Cruz. 2011;106:844-50 pubmed
    This population study, which evaluated two parasitological methods for the diagnosis of schistosomiasis mansoni, was performed in a low-transmission area in Pedra Preta, Montes Claros, Minas Gerais, Brazil...
  30. Attia Y, Elalkamy E, Hammam O, Mahmoud S, El Khatib A. Telmisartan, an AT1 receptor blocker and a PPAR gamma activator, alleviates liver fibrosis induced experimentally by Schistosoma mansoni infection. Parasit Vectors. 2013;6:199 pubmed publisher
    ..The present study has aimed at testing the anti-fibrogenic effects of telmisartan; an AT1 receptor blocker and a PPAR? partial agonist, alone or combined with praziquantel (PZQ) on Schistosoma mansoni-induced liver fibrosis in mice...
  31. Tweyongyere R, Mawa P, Kihembo M, Jones F, Webb E, Cose S, et al. Effect of praziquantel treatment of Schistosoma mansoni during pregnancy on immune responses to schistosome antigens among the offspring: results of a randomised, placebo-controlled trial. BMC Infect Dis. 2011;11:234 pubmed publisher
    ..Whether the treatment will impact upon the offspring's responses on exposure to primary schistosome infection remains to be elucidated. ISRCTN: ISRCTN32849447. ..
  32. Hanemann A, Libório A, Daher E, Martins A, Pinheiro M, Sousa M, et al. Monocyte chemotactic protein-1 (MCP-1) in patients with chronic schistosomiasis mansoni: evidences of subclinical renal inflammation. PLoS ONE. 2013;8:e80421 pubmed publisher
    The aim of this study is to investigate renal markers and the biomarker MCP-1 in patients with schistosomiasis mansoni. This is a cross-sectional study with 85 patients aged 5 to 48 years, with a confirmed diagnosis of schistosomiasis ..
  33. Enk M, Amaral G, Costa e Silva M, Silveira Lemos D, Teixeira Carvalho A, Martins Filho O, et al. Rural tourism: a risk factor for schistosomiasis transmission in Brazil. Mem Inst Oswaldo Cruz. 2010;105:537-40 pubmed
  34. Green H, Sousa Figueiredo J, Basanez M, Betson M, Kabatereine N, Fenwick A, et al. Anaemia in Ugandan preschool-aged children: the relative contribution of intestinal parasites and malaria. Parasitology. 2011;138:1534-45 pubmed publisher
    ..Looking to the future, these activities could be further emphasised within the National Child Health Days(PLUS) agenda...
  35. Blanton R, Blank W, Costa J, Carmo T, Reis E, Silva L, et al. Schistosoma mansoni population structure and persistence after praziquantel treatment in two villages of Bahia, Brazil. Int J Parasitol. 2011;41:1093-9 pubmed publisher
    ..007 and 0.020 for the two villages), suggesting that the persistent parasites were not selected by praziquantel treatment. We will continue to follow these communities for evidence of selection or changes in population structure...
  36. El Lakkany N, el Din S, Ebeid F. The use of pentoxifylline as adjuvant therapy with praziquantel downregulates profibrogenic cytokines, collagen deposition and oxidative stress in experimental schistosomiasis mansoni. Exp Parasitol. 2011;129:152-7 pubmed publisher
    ..Treatment of infected mice with PTX in addition to PZQ curative rather than its sub curative dose produced the best results evidenced by complete normalization in the previously mentioned serum and hepatic parameters...
  37. Stothard J, Sousa Figueiredo J, Betson M, Seto E, Kabatereine N. Investigating the spatial micro-epidemiology of diseases within a point-prevalence sample: a field applicable method for rapid mapping of households using low-cost GPS-dataloggers. Trans R Soc Trop Med Hyg. 2011;105:500-6 pubmed publisher
  38. Melo C, de Lima A, Beltrão E, Cavalcanti C, de Melo Junior M, Montenegro S, et al. Potential effects of Cramoll 1,4 lectin on murine Schistosomiasis mansoni. Acta Trop. 2011;118:152-8 pubmed publisher
    ..5%) in relation to control. This study showed the potential anti-helminthic activity of Cramoll 1,4 when tested against Schistosomiasis mansoni infection in mice.
  39. Stothard J, Sousa Figueiredo J, Betson M, Green H, Seto E, Garba A, et al. Closing the praziquantel treatment gap: new steps in epidemiological monitoring and control of schistosomiasis in African infants and preschool-aged children. Parasitology. 2011;138:1593-606 pubmed publisher
    ..mansoni appears to diminish after repeated rounds of treatment. Thus use of PZQ should be combined with appropriate health education/water hygiene improvements for both child and mother to bring forth a more enduring solution. ..
  40. Coulibaly J, N Goran E, Utzinger J, Doenhoff M, Dawson E. A new rapid diagnostic test for detection of anti-Schistosoma mansoni and anti-Schistosoma haematobium antibodies. Parasit Vectors. 2013;6:29 pubmed publisher
    ..Here, we assessed the diagnostic performance of the SmCTF-RDT for S. mansoni and S. haematobium infections by comparing it with microscopy for egg detection...
  41. Phythian Adams A, Cook P, Lundie R, Jones L, Smith K, Barr T, et al. CD11c depletion severely disrupts Th2 induction and development in vivo. J Exp Med. 2010;207:2089-96 pubmed publisher
  42. Norton A, Gower C, Lamberton P, Webster B, Lwambo N, Blair L, et al. Genetic consequences of mass human chemotherapy for Schistosoma mansoni: population structure pre- and post-praziquantel treatment in Tanzania. Am J Trop Med Hyg. 2010;83:951-7 pubmed publisher
    ..Such unique results illustrate the importance of genetic monitoring and examination of long lived multi-cellular parasites such as these under novel or increased chemotherapeutic selective pressures...
  43. Coulibaly J, N gbesso Y, Knopp S, Keiser J, N Goran E, Utzinger J. Efficacy and safety of praziquantel in preschool-aged children in an area co-endemic for Schistosoma mansoni and S. haematobium. PLoS Negl Trop Dis. 2012;6:e1917 pubmed publisher
    ..Since a pediatric formulation (e.g., syrup) is not available outside of Egypt, crushed praziquantel tablets are used, but the efficacy and safety of this treatment regimen is insufficiently studied...
  44. Eissa M, El Azzouni M, Amer E, Baddour N. Miltefosine, a promising novel agent for schistosomiasis mansoni. Int J Parasitol. 2011;41:235-42 pubmed publisher
    ..In conclusion, we believe this is the first study highlighting miltefosine as a promising novel agent for schistosomiasis mansoni.
  45. Koroma J, Peterson J, Gbakima A, Nylander F, Sahr F, Soares Magalhaes R, et al. Geographical distribution of intestinal schistosomiasis and soil-transmitted helminthiasis and preventive chemotherapy strategies in Sierra Leone. PLoS Negl Trop Dis. 2010;4:e891 pubmed publisher
  46. Rodrigues V, Otoni A, Voieta I, Antunes C, Lambertucci J. Glomerulonephritis in schistosomiasis mansoni: a time to reappraise. Rev Soc Bras Med Trop. 2010;43:638-42 pubmed
    The current prevalence of glomerulonephritis in patients with hepatosplenic schistosomiasis mansoni in Brazil was evaluated.
  47. Mentink Kane M, Cheever A, Wilson M, Madala S, Beers L, Ramalingam T, et al. Accelerated and progressive and lethal liver fibrosis in mice that lack interleukin (IL)-10, IL-12p40, and IL-13R?2. Gastroenterology. 2011;141:2200-9 pubmed publisher
    ..We examined whether these mediators interact to slow the progression of hepatic fibrosis in mice with schistosomiasis...
  48. El Lakkany N, El Maadawy W, Ain Shoka A, Badawy A, Hammam O, Ebeid F. Potential antifibrotic effects of AT1 receptor antagonist, losartan, and/or praziquantel on acute and chronic experimental liver fibrosis induced by Schistosoma mansoni. Clin Exp Pharmacol Physiol. 2011;38:695-704 pubmed publisher
    ..4. In conclusion, losartan has a promising antifibrotic action and could be introduced as a therapeutic tool with PZQ especially in acute schistosomal hepatic fibrosis...
  49. Meurs L, Mbow M, Vereecken K, Menten J, Mboup S, Polman K. Epidemiology of mixed Schistosoma mansoni and Schistosoma haematobium infections in northern Senegal. Int J Parasitol. 2012;42:305-11 pubmed publisher
    ..mansoni and S. haematobium, may influence disease epidemiology and control considerably, and merit further studies into the underlying mechanisms of Schistosoma infections in co-endemic areas...
  50. Martins Bedê F, Dutra L, Freitas C, Guimarães R, Amaral R, Drummond S, et al. Schistosomiasis risk mapping in the state of Minas Gerais, Brazil, using a decision tree approach, remote sensing data and sociological indicators. Mem Inst Oswaldo Cruz. 2010;105:541-8 pubmed
    b>Schistosomiasis mansoni is not just a physical disease, but is related to social and behavioural factors as well. Snails of the Biomphalaria genus are an intermediate host for Schistosoma mansoni and infect humans through water...
  51. Van Lume D, Albuquerque M, Souza A, Domingues A, Lopes E, Morais C, et al. Association between Schistosomiasis mansoni and hepatitis C: systematic review. Rev Saude Publica. 2013;47:414-24 pubmed publisher
    ..To perform a systematic review of the prevalence of the HCV/ S. mansoni co-infection and associated factors in Schistosoma mansoni -infected populations...
  52. Manneck T, Braissant O, Ellis W, Keiser J. Schistosoma mansoni: antischistosomal activity of the four optical isomers and the two racemates of mefloquine on schistosomula and adult worms in vitro and in vivo. Exp Parasitol. 2011;127:260-9 pubmed publisher
    ..Our results may enhance our understanding of the mechanism of action and therapeutic profile of MQ derivates on schistosomes...
  53. Abdeen S. Idiotype/anti-idiotype immunoregulatory network correlates with an improved clinical outcome of schistosomiasis mansoni in humans. Pak J Biol Sci. 2011;14:375-84 pubmed
    ..To study the correlation of anti-Ids with schistosomiasis mansoni morbidity, ELISA using polyclonal idiotypes (Ids) was used to determine the presence of anti-Ids in sera ..
  54. Barbosa C, Leal Neto O, Gomes E, Araújo K, Domingues A. The endemisation of schistosomiasis in Porto de Galinhas, Pernambuco, Brazil, 10 years after the first epidemic outbreak. Mem Inst Oswaldo Cruz. 2011;106:878-83 pubmed
    ..These findings, together with visual observation of insalubrious environmental conditions, indicate that schistosomiasis has become endemic in Porto de Galinhas...
  55. Gower C, Gouvras A, Lamberton P, Deol A, Shrivastava J, Mutombo P, et al. Population genetic structure of Schistosoma mansoni and Schistosoma haematobium from across six sub-Saharan African countries: implications for epidemiology, evolution and control. Acta Trop. 2013;128:261-74 pubmed publisher
    ..Our results are discussed in terms of their potential implications for the epidemiology and evolution of schistosomes as well as their subsequent control across sub-Saharan Africa. ..
  56. Meurs L, Mbow M, Vereecken K, Menten J, Mboup S, Polman K. Bladder morbidity and hepatic fibrosis in mixed Schistosoma haematobium and S. mansoni Infections: a population-wide study in Northern Senegal. PLoS Negl Trop Dis. 2012;6:e1829 pubmed publisher
    ..Here, we investigated the relationship between mixed Schistosoma infections and morbidity in the same population. So far, this has only been studied in children...
  57. French M, Churcher T, Gambhir M, Fenwick A, Webster J, Kabatereine N, et al. Observed reductions in Schistosoma mansoni transmission from large-scale administration of praziquantel in Uganda: a mathematical modelling study. PLoS Negl Trop Dis. 2010;4:e897 pubmed publisher
    ..The results obtained will have implications for evaluating the cost-effectiveness of schistosomiasis control programmes and the design of monitoring and evaluation approaches in general. ..
  58. Hussein H, El Tonsy M, Tawfik R, Ahmed S. Experimental study for early diagnosis of prepatent schistosomiasis mansoni by detection of free circulating DNA in serum. Parasitol Res. 2012;111:475-8 pubmed publisher
    ..i., while IHA failed to detect infection up to the eighth week p.i. It is concluded that detection of free circulating DNA by PCR can be used as a valuable test for early diagnosis of prepatent S. mansoni infection...
  59. Grant A, Araujo M, Ponte E, Oliveira R, Gao P, Cruz A, et al. Functional polymorphisms in IL13 are protective against high Schistosoma mansoni infection intensity in a Brazilian population. PLoS ONE. 2012;7:e35863 pubmed publisher
    ..IL-13 is a signature cytokine of the helper T cell type 2 (TH2) pathway which underlies host defense to helminthic infection and activates production of IgE in both parasitized populations and in urban settings after allergen exposure...
  60. Blank W, Liu S, Prasad J, Blanton R. Host mouse strain is not selective for a laboratory adapted strain of Schistosoma mansoni. J Parasitol. 2011;97:518-21 pubmed publisher
    ..Schistosoma mansoni egg allele frequencies were also equally distributed in tissues and the difference between adult and egg allele frequencies was negligible...
  61. Ashton R, Stewart B, Petty N, Lado M, Finn T, Brooker S, et al. Accuracy of circulating cathodic antigen tests for rapid mapping of Schistosoma mansoni and S. haematobium infections in Southern Sudan. Trop Med Int Health. 2011;16:1099-103 pubmed publisher
    ..To evaluate the diagnostic accuracy of a circulating cathodic antigen (CCA) urine dipstick test for detecting Schistosoma mansoni and S. haematobium alongside an integrated rapid mapping survey in Southern Sudan...
  62. Hanington P, Forys M, Dragoo J, Zhang S, Adema C, Loker E. Role for a somatically diversified lectin in resistance of an invertebrate to parasite infection. Proc Natl Acad Sci U S A. 2010;107:21087-92 pubmed publisher
    ..FREP3 up-regulation is also associated with heightened responsiveness following priming with attenuated digenetic trematodes (acquired resistance) in this model invertebrate immune system...
  63. Standley C, Mugisha L, Adriko M, Arinaitwe M, Rukundo J, Ajarova L, et al. Intestinal schistosomiasis in chimpanzees on Ngamba Island, Uganda: observations on liver fibrosis, schistosome genetic diversity and praziquantel treatment. Parasitology. 2013;140:285-95 pubmed publisher
  64. Sousa Figueiredo J, Day M, Betson M, Rowell C, Wamboko A, Arinaitwe M, et al. Field survey for strongyloidiasis in eastern Uganda with observations on efficacy of preventive chemotherapy and co-occurrence of soil-transmitted helminthiasis/intestinal schistosomiasis. J Helminthol. 2011;85:325-33 pubmed publisher
    ..stercoralis, careful interpretation of the ELISA is warranted, especially where diagnosis is likely being confounded by polyparasitism and/or other treatment regimens; new molecular screening tools are clearly needed...
  65. Pinheiro M, Carneiro T, Hanemann A, Oliveira S, Bezerra F. The combination of three faecal parasitological methods to improve the diagnosis of schistosomiasis mansoni in a low endemic setting in the state of Ceará, Brazil. Mem Inst Oswaldo Cruz. 2012;107:873-6 pubmed
    Laboratory diagnosis of intestinal schistosomiasis mansoni can be accomplished through various methods of stool examination to detect parasites, ranging from the most classic tests (Kato-Katz) to several methods that are still undergoing ..
  66. El Lakkany N, Hammam O, El Maadawy W, Badawy A, Ain Shoka A, Ebeid F. Anti-inflammatory/anti-fibrotic effects of the hepatoprotective silymarin and the schistosomicide praziquantel against Schistosoma mansoni-induced liver fibrosis. Parasit Vectors. 2012;5:9 pubmed publisher
    ..This study investigates the anti-inflammatory/anti-fibrotic effects of silymarin and/or PZQ on schistosomal hepatic fibrosis...
  67. Stothard J, Sousa Figueiredo J, Sousa Figuereido J, Betson M, Adriko M, Arinaitwe M, et al. Schistosoma mansoni Infections in young children: when are schistosome antigens in urine, eggs in stool and antibodies to eggs first detectable?. PLoS Negl Trop Dis. 2011;5:e938 pubmed publisher
    ..In the context of future epidemiological monitoring, we sought to compare the detection thresholds of available diagnostic tools for Schistosoma mansoni and estimate a likely age of first infection for these children...
  68. Turner J, Jenkins G, Hogg K, Aynsley S, Paveley R, Cook P, et al. CD4+CD25+ regulatory cells contribute to the regulation of colonic Th2 granulomatous pathology caused by schistosome infection. PLoS Negl Trop Dis. 2011;5:e1269 pubmed publisher
    ..Therefore, CD4+CD25+FoxP3+T(regs) appear to control Th2 colonic granulomas during chronic infection, and are likely to play a role in containing pathology during intestinal schistosomiasis...
  69. Schur N, Gosoniu L, Raso G, Utzinger J, Vounatsou P. Modelling the geographical distribution of co-infection risk from single-disease surveys. Stat Med. 2011;30:1761-76 pubmed publisher
    ..Co-infection risk is preferably estimated via Bayesian geostatistical multinomial modelling, using data from surveys screening for multiple infections simultaneously. However, only few surveys have collected this type of data...