schistosomiasis japonica

Summary

Summary: Schistosomiasis caused by Schistosoma japonicum. It is endemic in the Far East and affects the bowel, liver, and spleen.

Top Publications

  1. Xu J, Rong R, Zhang H, Shi C, Zhu X, Xia C. Sensitive and rapid detection of Schistosoma japonicum DNA by loop-mediated isothermal amplification (LAMP). Int J Parasitol. 2010;40:327-31 pubmed publisher
    ..The established LAMP assay should provide a useful and practical tool for the routine diagnosis and therapeutic evaluation of human schistosomiasis...
  2. Sun L, Wang W, Liang Y, Tian Z, Hong Q, Yang K, et al. Effect of an integrated control strategy for schistosomiasis japonica in the lower reaches of the Yangtze River, China: an evaluation from 2005 to 2008. Parasit Vectors. 2011;4:243 pubmed publisher
    b>Schistosomiasis japonica remains a major public health concern in China. There are many interventions implemented to control the transmission of the disease...
  3. Cai P, Hou N, Piao X, Liu S, Liu H, Yang F, et al. Profiles of small non-coding RNAs in Schistosoma japonicum during development. PLoS Negl Trop Dis. 2011;5:e1256 pubmed publisher
    ..japonicum with high accuracy and coverage. The data would facilitate a deep understanding of the parasite biology and potential discovery of novel targets for the design of anti-parasite drugs. ..
  4. Zhang Y, Luo J, Liu Y, Wang Q, Chen J, Xu M, et al. Evaluation of Kato-Katz examination method in three areas with low-level endemicity of schistosomiasis japonica in China: A Bayesian modeling approach. Acta Trop. 2009;112:16-22 pubmed publisher
    ..There is a pressing need to develop more sensitive diagnostic tools for accurate detection of light infection intensities of schistosome infections. ..
  5. Peng J, Han H, Gobert G, Hong Y, Jiang W, Wang X, et al. Differential gene expression in Schistosoma japonicum schistosomula from Wistar rats and BALB/c mice. Parasit Vectors. 2011;4:155 pubmed publisher
    ..japonicum oligonucleotide microarray to compare the gene expression differences of 10-day-old schistosomula maintained in Wistar rats with those maintained in BALB/c mice...
  6. Zhu H, Yu C, Xia X, Dong G, Tang J, Fang L, et al. Assessing the diagnostic accuracy of immunodiagnostic techniques in the diagnosis of schistosomiasis japonica: a meta-analysis. Parasitol Res. 2010;107:1067-73 pubmed publisher
    Immunodiagnostic tests are commonly used in the diagnosis for schistosomiasis japonica in field situation. Their diagnostic effect, however, has never been evaluated in a systematic way...
  7. Steinmann P, Zhou X, Matthys B, Li Y, Li H, Chen S, et al. Spatial risk profiling of Schistosoma japonicum in Eryuan county, Yunnan province, China. Geospat Health. 2007;2:59-73 pubmed
  8. Zhu H, Xiang S, Yang K, Wu X, Zhou X. Three Gorges Dam and its impact on the potential transmission of schistosomiasis in regions along the Yangtze River. Ecohealth. 2008;5:137-48 pubmed publisher
  9. Arnaud V, Li J, Wang Y, Fu X, Mengzhi S, Luo X, et al. Regulatory role of interleukin-10 and interferon-gamma in severe hepatic central and peripheral fibrosis in humans infected with Schistosoma japonicum. J Infect Dis. 2008;198:418-26 pubmed publisher
    ..IL-10 is associated with protection against central fibrosis, because of its anti-inflammatory and antifibrosis effects. IFN-gamma is associated with protection against PerF, which depends more on egg load and egg-associated toxicity. ..

More Information

Publications84

  1. Peng W, Tao B, Clements A, Jiang Q, Zhang Z, Zhou Y, et al. Identifying high-risk areas of schistosomiasis and associated risk factors in the Poyang Lake region, China. Parasitology. 2010;137:1099-107 pubmed publisher
    ..Such information can be used to plan locally targeted interventions based on anthelminthic drug administration, snail control and sanitation improvement. ..
  2. Lier T, Simonsen G, Wang T, Lu D, Haukland H, Vennervald B, et al. Low sensitivity of the formol-ethyl acetate sedimentation concentration technique in low-intensity Schistosoma japonicum infections. PLoS Negl Trop Dis. 2009;3:e386 pubmed publisher
    ..6% and specificity of 97.4%. This study indicates that the sedimentation technique has little to offer in the diagnosis of low-intensity S. japonicum infections, at least when only a single stool sample is examined. ..
  3. Guo F, Wang Y, Li Y, Peng J, Hong Y, Qiu C, et al. [Evaluation on the immuno-protective efficacy of the recombinant antigen SjPGAM-SjEnol against Schistosoma japonicum in mice]. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 2010;28:246-51 pubmed
    ..To construct and express the recombinant plasmid pET32a-SjPGAM-SjEnol and evaluate its immuno-protective efficacy against the infection of Schistosoma japonicum in mice...
  4. Luo Q, Qiao Z, Zhou Y, Li X, Zhong Z, Yu Y, et al. Application of signaling protein 14-3-3 and 26 kDa glutathione-S-transferase to serological diagnosis of Schistosomiasis japonica. Acta Trop. 2009;112:91-6 pubmed publisher
    b>Schistosomiasis japonica is currently one of the most serious parasitic diseases and over 670000 people are infected in China by the end of 2006...
  5. Hung Y, Remais J. Quantitative detection of Schistosoma japonicum cercariae in water by real-time PCR. PLoS Negl Trop Dis. 2008;2:e337 pubmed publisher
    ..Overall, the method has the potential to be applied to environmental water samples to produce a rapid, reliable assay for cercarial location in endemic areas. ..
  6. Qian C, Song L, Hua W, Yin X, Wang J, Zhang W, et al. Kinetics of circulating antigen 14-3-3 in sera of rabbits firstly infected with Schistosoma japonicum and treated with/without praziquantel. Parasitol Res. 2011;108:493-5 pubmed publisher
    ..Our findings showed that detection of S. japonicum 14-3-3 has an important value for diagnosis of acute infection of S. japonicum and evaluation of chemotherapy...
  7. Yang J, Zhao Z, Li Y, Krewski D, Wen S. A multi-level analysis of risk factors for Schistosoma japonicum infection in China. Int J Infect Dis. 2009;13:e407-12 pubmed publisher
    The aim of this study was to explore the risk factors of schistosomiasis japonica in China, using a hierarchical multi-level model with individuals nested within villages...
  8. Zhu R, Gray D, Thrift A, Williams G, Zhang Y, Qiu D, et al. A 5-year longitudinal study of schistosomiasis transmission in Shian village, the Anning River Valley, Sichuan Province, the Peoples' Republic of China. Parasit Vectors. 2011;4:43 pubmed publisher
    ..Here we present the results from a schistosomiasis-endemic village located above the dam in Sichuan Province...
  9. McManus D, Li Y, Gray D, Ross A. Conquering 'snail fever': schistosomiasis and its control in China. Expert Rev Anti Infect Ther. 2009;7:473-85 pubmed publisher
    b>Schistosomiasis japonica is a serious parasitic disease and a major health risk for more than 60 million people living in the tropical and subtropical zones of south China...
  10. Remais J, Zhong B, Carlton E, Spear R. Model approaches for estimating the influence of time-varying socio-environmental factors on macroparasite transmission in two endemic regions. Epidemics. 2009;1:213-20 pubmed publisher
    ..The importance of these factors for control programs and surveillance is discussed. ..
  11. Wang L, Guo J, Wu X, Chen H, Wang T, Zhu S, et al. China's new strategy to block Schistosoma japonicum transmission: experiences and impact beyond schistosomiasis. Trop Med Int Health. 2009;14:1475-83 pubmed publisher
  12. Wang X, Gobert G, Feng X, Fu Z, Jin Y, Peng J, et al. Analysis of early hepatic stage schistosomula gene expression by subtractive expressed sequence tags library. Mol Biochem Parasitol. 2009;166:62-9 pubmed publisher
    ..The future identification of poorly annotated but stage-specific genes may potentially represent new drugs or vaccine targets, applicable for the future controlling of schistosomiasis. ..
  13. Lu D, Wang T, Rudge J, Donnelly C, Fang G, Webster J. Contrasting reservoirs for Schistosoma japonicum between marshland and hilly regions in Anhui, China--a two-year longitudinal parasitological survey. Parasitology. 2010;137:99-110 pubmed publisher
    ..Such results may have implications for the current human- and bovine-oriented control policy for this medically and veterinarily important disease, particularly within the hilly regions of mainland China. ..
  14. Nihei N, Komagata O, Kobayashi M, Saitoh Y, Mochizuki K, Nakamura S. Spatial analysis and remote sensing for monitoring systems of Oncomelania nosophora following the eradication of schistosomiasis japonica in Yamanashi Prefecture, Japan. Jpn J Infect Dis. 2009;62:125-32 pubmed
    In order to develop an inexpensive, simple, and accurate method of monitoring for the reemergence of schistosomiasis japonica in Yamanashi Prefecture, Japan, the distribution and habitation density of the intermediate host, Oncomelania ..
  15. Luo R, Zhou C, Lin J, Yang D, Shi Y, Cheng G. Identification of in vivo protein phosphorylation sites in human pathogen Schistosoma japonicum by a phosphoproteomic approach. J Proteomics. 2012;75:868-77 pubmed publisher
  16. Wang W, Dai J, Li H, Shen X, Liang Y. Is there reduced susceptibility to praziquantel in Schistosoma japonicum? Evidence from China. Parasitology. 2010;137:1905-12 pubmed publisher
    ..It is suggested that no evidence of tolerance or resistance to praziquantel in S. japonicum was detected in China...
  17. Hong Q, Yang K, Huang Y, Sun L, Yang G, Gao Y, et al. Effectiveness of a comprehensive schistosomiasis japonica control program in Jiangsu province, China, from 2005 to 2008. Acta Trop. 2011;120 Suppl 1:S151-7 pubmed publisher
    The effectiveness of a comprehensive schistosomiasis japonica control program implemented in 8 villages along the Yangtze river in Jiangsu province from 2005 to 2008 was studied...
  18. Zhao G, Mo X, Zou F, Li J, Weng Y, Lin R, et al. Genetic variability among Schistosoma japonicum isolates from different endemic regions in China revealed by sequences of three mitochondrial DNA genes. Vet Parasitol. 2009;162:67-74 pubmed publisher
    ..japonicum, and have implications for studying population biology, molecular epidemiology, and genetic structure of S. japonicum, as well as for the effective control of schistosomiasis...
  19. Ellis M, McManus D. Familial aggregation of human helminth infection in the Poyang lake area of China with a focus on genetic susceptibility to schistosomiasis japonica and associated markers of disease. Parasitology. 2009;136:699-712 pubmed publisher
    ..We discuss the role of sICAM-1 and TNFR-I and -II as candidate markers for schistosome-induced hepatomegaly and fibrosis, and their potential for assessing disease stage and progression in schistosomiasis...
  20. Xu J, Xu J, Li S, Jia T, Huang X, Zhang H, et al. Transmission risks of schistosomiasis japonica: extraction from back-propagation artificial neural network and logistic regression model. PLoS Negl Trop Dis. 2013;7:e2123 pubmed publisher
    The transmission of schistosomiasis japonica in a local setting is still poorly understood in the lake regions of the People's Republic of China (P. R...
  21. Yin M, Hu W, Mo X, Wang S, Brindley P, McManus D, et al. Multiple near-identical genotypes of Schistosoma japonicum can occur in snails and have implications for population-genetic analyses. Int J Parasitol. 2008;38:1681-91 pubmed publisher
    ..We regard somatic mutation as the most likely explanation for our results. The implications of multiple MLGs for population-genetic studies in S. japonicum are discussed...
  22. Han H, Peng J, Hong Y, Zhang M, Han Y, Liu D, et al. MicroRNA expression profile in different tissues of BALB/c mice in the early phase of Schistosoma japonicum infection. Mol Biochem Parasitol. 2013;188:1-9 pubmed publisher
    ..This may be helpful in the search for potential new drugs, and for biomarkers of early S. japonicum infection applicable in the future control of schistosomiasis...
  23. Xu J, Feng T, Lin D, Wang Q, Tang L, Wu X, et al. Performance of a dipstick dye immunoassay for rapid screening of Schistosoma japonicum infection in areas of low endemicity. Parasit Vectors. 2011;4:87 pubmed publisher
    ..Stool samples were collected and examined by the Kato-Katz method and the miracidium hatching technique. Serum samples, separated from whole blood of participants, were tested by DDIA...
  24. Peng J, Han H, Hong Y, Wang Y, Guo F, Shi Y, et al. [Cloning and expressing of cyclophilin B gene from Schistosoma japonnicum and the analysis of immunoprotective effect]. Sheng Wu Gong Cheng Xue Bao. 2010;26:317-23 pubmed
    ..A full-length cDNA differentially expressed in schistosomula was obtained. The recombinant Sj CyPB protein could induce partial protection against schistosome infection...
  25. Xia C, Rong R, Lu Z, Shi C, Xu J, Zhang H, et al. Schistosoma japonicum: a PCR assay for the early detection and evaluation of treatment in a rabbit model. Exp Parasitol. 2009;121:175-9 pubmed publisher
    ..These data demonstrated that the PCR assay established provides a potential tool for the early diagnosis and therapy evaluation for S. japonicum infection in humans...
  26. Jin Y, Lu K, Zhou W, Fu Z, Liu J, Shi Y, et al. Comparison of Recombinant Proteins from Schistosoma japonicum for Schistosomiasis Diagnosis. Clin Vaccine Immunol. 2010;17:476-80 pubmed publisher
    ..We evaluated the potentials of the recombinant proteins for discriminating active from prior infections, as well as the therapeutic efficacy of the established ELISA technique...
  27. Dai Y, Zhu Y, Harn D, Wang X, Tang J, Zhao S, et al. DNA vaccination by electroporation and boosting with recombinant proteins enhances the efficacy of DNA vaccines for Schistosomiasis japonica. Clin Vaccine Immunol. 2009;16:1796-803 pubmed publisher
    b>Schistosomiasis japonica is an endemic, zoonotic disease of major public health importance in China...
  28. Sun L, Liang Y, Wu H, Tian Z, Dai J, Yang K, et al. A Google Earth-based surveillance system for schistosomiasis japonica implemented in the lower reaches of the Yangtze River, China. Parasit Vectors. 2011;4:223 pubmed publisher
    ..In this study, we imported Google Earth technology and a Global Positioning System (GPS) into the monitoring system for schistosomiasis surveillance of the banks of the Yangtze River in Jiangsu Province, China...
  29. Lier T, Simonsen G, Wang T, Lu D, Haukland H, Vennervald B, et al. Real-time polymerase chain reaction for detection of low-intensity Schistosoma japonicum infections in China. Am J Trop Med Hyg. 2009;81:428-32 pubmed
    ..As prevalence and intensity decrease, the benefit of increased sensitivity using the PCR must be weighed against additional costs...
  30. Wang X, Zhou S, Chi Y, Wen X, Hoellwarth J, He L, et al. CD4+CD25+ Treg induction by an HSP60-derived peptide SJMHE1 from Schistosoma japonicum is TLR2 dependent. Eur J Immunol. 2009;39:3052-65 pubmed publisher
    ..These findings provide the basis for a more complete understanding of the S. japonicum-host interactions that contribute to host homeostatic mechanisms, preventing an excessive immune response...
  31. Xu X, Zhang D, Sun W, Zhang Q, Zhang J, Xue X, et al. A Schistosoma japonicum chimeric protein with a novel adjuvant induced a polarized Th1 immune response and protection against liver egg burdens. BMC Infect Dis. 2009;9:54 pubmed publisher
    ..We tested these four proteins as vaccine candidates, and investigated the effect of deviating immune response on protection roles in mice...
  32. Tao F, Yang Y, Wang H, Sun X, Luo J, Zhu X, et al. Th1-type epitopes-based cocktail PDDV attenuates hepatic fibrosis in C57BL/6 mice with chronic Schistosoma japonicum infection. Vaccine. 2009;27:4110-7 pubmed publisher
  33. Zhou Y, Yang M, Tao P, Jiang Q, Zhao G, Wei J, et al. A longitudinal study of comparison of the Kato-Katz technique and indirect hemagglutination assay (IHA) for the detection of schistosomiasis japonica in China, 2001-2006. Acta Trop. 2008;107:251-4 pubmed publisher
    ..g. with >10% or more prevalence). A search for a better diagnostic test that can be applied in field situations in China is essential and should be given high priority...
  34. Gray D, Williams G, Li Y, Chen H, Forsyth S, Li R, et al. A cluster-randomised intervention trial against Schistosoma japonicum in the Peoples' Republic of China: bovine and human transmission. PLoS ONE. 2009;4:e5900 pubmed publisher
    Zoonotic schistosomiasis japonica is a major public health problem in China. Bovines, particularly water buffaloes, are thought to play a major role in the transmission of schistosomiasis to humans in China...
  35. Rudge J, Lu D, Fang G, Wang T, Basanez M, Webster J. Parasite genetic differentiation by habitat type and host species: molecular epidemiology of Schistosoma japonicum in hilly and marshland areas of Anhui Province, China. Mol Ecol. 2009;18:2134-47 pubmed publisher
    ..japonicum control, particularly in hilly regions where control of infection among wild rodent populations could be challenging...
  36. Perry C, Burke M, Stenzel D, McManus D, Ramm G, Gobert G. Differential expression of chemokine and matrix re-modelling genes is associated with contrasting schistosome-induced hepatopathology in murine models. PLoS Negl Trop Dis. 2011;5:e1178 pubmed publisher
    ..This improved understanding of the immunopathogenesis in the murine model schistosomiasis provides the basis for a better appreciation of the complexities associated with chronic human schistosomiasis...
  37. Wu W, Huang Y. Application of praziquantel in schistosomiasis japonica control strategies in China. Parasitol Res. 2013;112:909-15 pubmed publisher
    ..a major public health problem with an estimated 200 million people infected in the world, and in China, schistosomiasis japonica is endemic in the south part of the country...
  38. Seki T, Kumagai T, Kwansa Bentum B, Furushima Shimogawara R, Anyan W, Miyazawa Y, et al. Interleukin-4 (IL-4) and IL-13 suppress excessive neutrophil infiltration and hepatocyte damage during acute murine schistosomiasis japonica. Infect Immun. 2012;80:159-68 pubmed publisher
    ..liver damage, we analyzed the mechanisms underlying neutrophil and proinflammatory responses in murine schistosomiasis japonica. We found that granulomatous inflammation around parasite eggs in the liver was greater in Schistosoma ..
  39. Xue X, Sun J, Zhang Q, Wang Z, Huang Y, Pan W. Identification and characterization of novel microRNAs from Schistosoma japonicum. PLoS ONE. 2008;3:e4034 pubmed publisher
    b>Schistosomiasis japonica remains a major public health problem in China. Its pathogen, Schistosoma japonicum has a complex life cycle and a unique repertoire of genes expressed at different life cycle stages...
  40. Zhou X, Xu J, Chen H, Wang T, Huang X, Lin D, et al. Tools to support policy decisions related to treatment strategies and surveillance of Schistosomiasis japonica towards elimination. PLoS Negl Trop Dis. 2011;5:e1408 pubmed publisher
    ..R. China. We compared the efficacy and utility of different immunoassays in guiding control strategies and monitoring the endemic status of S. japonicum infections towards elimination...
  41. Yang G, Zhou X, Sun L, Wu F, Zhong B, Qiu D, et al. Compensatory density feedback of Oncomelania hupensis populations in two different environmental settings in China. Parasit Vectors. 2011;4:133 pubmed publisher
    ..We provide an empirical framework for discerning the relative contribution of intrinsic effects (density feedback) from other extrinsic drivers of snail population dynamics...
  42. Qiu C, Liu S, Hong Y, Fu Z, Wei M, Ai D, et al. Molecular characterization of thyroid hormone receptor beta from Schistosoma japonicum and assessment of its potential as a vaccine candidate antigen against schistosomiasis in BALB/c mice. Parasit Vectors. 2012;5:172 pubmed publisher
    ..The purpose of this study was to identify a novel thyroid hormone receptor beta encoding gene of Schistosoma japonicum (SjTHR?) and to investigate its potential as a vaccine candidate antigen against schistosomiasis in BALB/c mice...
  43. Hong Y, Peng J, Jiang W, Fu Z, Liu J, Shi Y, et al. Proteomic analysis of schistosoma japonicum schistosomulum proteins that are differentially expressed among hosts differing in their susceptibility to the infection. Mol Cell Proteomics. 2011;10:M110.006098 pubmed publisher
    ..japonicum living in different states and provides a basis for a better understanding of the molecular mechanisms in the development and survival of S. japonicum in different host environments...
  44. Xu J, Peeling R, Chen J, Wu X, Wu Z, Wang S, et al. Evaluation of immunoassays for the diagnosis of Schistosoma japonicum infection using archived sera. PLoS Negl Trop Dis. 2011;5:e949 pubmed publisher
    ..We compared the performance of nine immunodiagnostic tests developed in P.R. China for detection of antibodies against S. japonicum and established their priority for further assessment in field settings...
  45. Lin L, Wen L. [Role of Oncomelania hupensis in transmission of schistosomiasis japonica]. Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi. 2013;25:83-5, 89 pubmed
  46. Wei F, Liu Q, Gao S, Shang L, Zhai Y, Men J, et al. Enhancement by IL-18 of the protective effect of a Schistosoma japonicum 26kDa GST plasmid DNA vaccine in mice. Vaccine. 2008;26:4145-9 pubmed publisher
    ..Corresponding hepatic and fecal egg reductions were 44.8% and 53.0%, and 50.6% and 56.6%, respectively. These results indicate that IL-18 may be an effective adjuvant for a schistosomiasis vaccine...
  47. Wang X, Zhou X, Vounatsou P, Chen Z, Utzinger J, Yang K, et al. Bayesian spatio-temporal modeling of Schistosoma japonicum prevalence data in the absence of a diagnostic 'gold' standard. PLoS Negl Trop Dis. 2008;2:e250 pubmed publisher
    ..However, there is a paucity of studies focusing on spatio-temporal modeling that take into account the uncertainty of diagnostic techniques...
  48. Shaw J, Aggarwal N, Acosta L, Jiz M, Wu H, Leenstra T, et al. Reduction in hookworm infection after praziquantel treatment among children and young adults in Leyte, the Philippines. Am J Trop Med Hyg. 2010;83:416-21 pubmed publisher
    ..8%. Praziquantel treatment did not decrease the infection intensity of STHs. Control programs using praziquantel may have the added benefit of reducing hookworm infection and anemia in areas of coendemnicity...
  49. Chen Z, Zhou X, Yang K, Wang X, Yao Z, Wang T, et al. Strategy formulation for schistosomiasis japonica control in different environmental settings supported by spatial analysis: a case study from China. Geospat Health. 2007;1:223-31 pubmed
    With the aim of exploring the usefulness of spatial analysis in the formulation of a strategy for schistosomiasis japonica control in different environmental settings, a population-based database was established in Dangtu county, China...
  50. Wang L, Chen H, Guo J, Zeng X, Hong X, Xiong J, et al. A strategy to control transmission of Schistosoma japonicum in China. N Engl J Med. 2009;360:121-8 pubmed publisher
    ..Schistosoma japonicum causes an infection involving humans, livestock, and snails and is a significant cause of morbidity in China...
  51. Yuan C, Fu Y, Li J, Yue Y, Cai L, Xiao W, et al. Schistosoma japonicum: efficient and rapid purification of the tetraspanin extracellular loop 2, a potential protective antigen against schistosomiasis in mammalian. Exp Parasitol. 2010;126:456-61 pubmed publisher
    ..Character of the protein was analyzed via animal experiments and then clinical trials. The purification approach yielded pure Sj-TSP-2, which will provide feasible advices for discovering vaccines against schistosomiasis...
  52. Liu P, Li J, Shen Y, Zhu Y, Wang S, Wu Z, et al. Helminth infection inhibits airway allergic reaction and dendritic cells are involved in the modulation process. Parasite Immunol. 2010;32:57-66 pubmed publisher
    ..The results suggest that SJ infection may inhibit the development of allergy and that DCs may be involved in the process of helminth infection-mediated modulation of allergic inflammation...
  53. Abdel Hafeez E, Kikuchi M, Watanabe K, Ito T, Yu C, Chen H, et al. Proteome approach for identification of schistosomiasis japonica vaccine candidate antigen. Parasitol Int. 2009;58:36-44 pubmed publisher
    ..This protocol using proteome PF 2D could be applicable in identifying immunoreactive proteins from crude extract for the development of vaccines or for diagnostics...
  54. Lu Y, Xu B, Ju C, Mo X, Chen S, Feng Z, et al. Identification and profiling of circulating antigens by screening with the sera from schistosomiasis japonica patients. Parasit Vectors. 2012;5:115 pubmed publisher
    ..Different methods have been investigated for detecting the CAs. However, the components of the schistosome CAs remain unclear. In this study, we analyzed the CAs in sera of patients infected with Schistosoma japonicum...
  55. Liu J, Zhu C, Shi Y, Li H, Wang L, Qin S, et al. Surveillance of Schistosoma japonicum infection in domestic ruminants in the Dongting Lake region, Hunan province, China. PLoS ONE. 2012;7:e31876 pubmed publisher
    b>Schistosomiasis japonica is prevalent in Asian countries and it remains a major public health problem in China...
  56. Chen Q, Guan F, Yan D, Lei D, Fu L, Xia H, et al. The dynamic expression of allograft inflammatory factor-1 in hepatic tissues and splenic cells of BALB/c mice with Schistosoma japonicum infection. Tissue Antigens. 2012;79:33-41 pubmed publisher
    ..japonicum, and the interaction between AIF-1 and TNF-? or other cytokines played an important role in the pathogenesis and progression of hepatic schistosomiasis...
  57. Zhou Y, Zheng H, Jiang Q. A diagnostic challenge for Schistosomiasis japonica in China: consequences on praziquantel-based morbidity control. Parasit Vectors. 2011;4:194 pubmed publisher
    ..In this paper we review the current status of our knowledge about diagnostic tools for schistosomiasis japonica. A simple, affordable, sensitive, and specific assay for field diagnosis of schistosomiasis japonica is ..
  58. Wu H, Qin Y, Chu K, Meng R, Liu Y, McGarvey S, et al. High prevalence of Schistosoma japonicum infection in water buffaloes in the Philippines assessed by real-time polymerase chain reaction. Am J Trop Med Hyg. 2010;82:646-52 pubmed publisher
    ..japonicum infection in water buffaloes in the Philippines and warrant reexamination of the role of bovines in transmission of S. japonicum to humans in the Philippines...
  59. Hu H, Gong P, Xu B. Spatially explicit agent-based modelling for schistosomiasis transmission: human-environment interaction simulation and control strategy assessment. Epidemics. 2010;2:49-65 pubmed publisher
    ..Based on the life cycle of Schistosoma japonicum, some models have been developed. However, the human-environment interaction, especially through agricultural activities, has not been explicitly modeled in previous efforts...
  60. Burke M, McManus D, Ramm G, Duke M, Li Y, Jones M, et al. Co-ordinated gene expression in the liver and spleen during Schistosoma japonicum infection regulates cell migration. PLoS Negl Trop Dis. 2010;4:e686 pubmed publisher
  61. He Y, Li J, Zhuang W, Yin L, Chen C, Li J, et al. The inhibitory effect against collagen-induced arthritis by Schistosoma japonicum infection is infection stage-dependent. BMC Immunol. 2010;11:28 pubmed publisher
    ..The present study was designed to study whether different stages of schistosome infection offer unique protection in collagen-induced arthritis and its mechanisms...
  62. McManus D, Gray D, Li Y, Feng Z, Williams G, Stewart D, et al. Schistosomiasis in the People's Republic of China: the era of the Three Gorges Dam. Clin Microbiol Rev. 2010;23:442-66 pubmed publisher
    ..and considers the pathology, clinical outcomes, diagnosis, treatment, immunobiology, and genetics of schistosomiasis japonica together with an overview of current progress in vaccine development, all of which will have an impact on ..
  63. Li M, Lei J, Wang T, Lu S, Guan F, Liu W, et al. Cimetidine enhances the protective effect of GST DNA vaccine against Schistosoma japonicum. Exp Parasitol. 2011;128:427-32 pubmed publisher
    ..All these findings suggest that CIM as a potential schistosome DNA vaccine adjuvant can enhance the protective effect of pEGFP-Sj26GST vaccine...
  64. Lin D, Xu J, Zhang Y, Liu Y, Hu F, Xu X, et al. Evaluation of IgG-ELISA for the diagnosis of Schistosoma japonicum in a high prevalence, low intensity endemic area of China. Acta Trop. 2008;107:128-33 pubmed publisher
    ..We suggest marked caution in implementing anti-egg antigen IgG-ELISA based diagnosis for either individual level diagnosis or population-based targeting for national control programs...
  65. Zhou X, Bergquist R, Leonardo L, Yang G, Yang K, Sudomo M, et al. Schistosomiasis japonica control and research needs. Adv Parasitol. 2010;72:145-78 pubmed publisher
    b>Schistosomiasis japonica, a chronic and debilitating disease caused by the blood fluke Schistosoma japonicum, is still of considerable economic and public health concern in the People's Republic of China, the Philippines, and Indonesia...
  66. Peng J, Han H, Hong Y, Fu Z, Liu J, Lin J. Molecular cloning and characterization of a gene encoding methionine aminopeptidase 2 of Schistosoma japonicum. Parasitol Res. 2010;107:939-46 pubmed publisher
    ..The data presented here suggest that SjMAP2 is an important molecule in the development of the schistosome and that it may be a potential new drug target or vaccine candidate for schistosomiasis...
  67. Zhou Y, Liang S, Jiang Q. Factors impacting on progress towards elimination of transmission of schistosomiasis japonica in China. Parasit Vectors. 2012;5:275 pubmed publisher
    ..Assessing potential roles of these factors in the transmission and implications for current control strategies aiming at transmission interruption is needed...
  68. Hou X, McManus D, Gray D, Balen J, Luo X, He Y, et al. A randomized, double-blind, placebo-controlled trial of safety and efficacy of combined praziquantel and artemether treatment for acute schistosomiasis japonica in China. Bull World Health Organ. 2008;86:788-95 pubmed
    To evaluate the safety and efficacy of combining artemether (AM) and praziquantel (PZQ) in different regimens for treating acute schistosomiasis japonica.
  69. Yang J, Fu Z, Feng X, Shi Y, Yuan C, Liu J, et al. Comparison of worm development and host immune responses in natural hosts of Schistosoma japonicum, yellow cattle and water buffalo. BMC Vet Res. 2012;8:25 pubmed publisher
  70. Zhang W, Li J, Duke M, Jones M, Kuang L, Zhang J, et al. Inconsistent protective efficacy and marked polymorphism limits the value of Schistosoma japonicum tetraspanin-2 as a vaccine target. PLoS Negl Trop Dis. 2011;5:e1166 pubmed publisher
    ..Amplification by PCR of homologous sequences from male and female S. japonicum worms showed the presence of 7 different clusters or subclasses of S. japonicum TSP-2. We determined the protective efficacy of one subclass - Sj-TSP-2e...
  71. Jiz M, Friedman J, Leenstra T, Jarilla B, Pablo A, Langdon G, et al. Immunoglobulin E (IgE) responses to paramyosin predict resistance to reinfection with Schistosoma japonicum and are attenuated by IgG4. Infect Immun. 2009;77:2051-8 pubmed publisher
    ..cytokine responses, these data further support paramyosin as a leading vaccine candidate for human schistosomiasis japonica and underscore the importance of careful adjuvant selection to avoid the generation of blocking IgG4 ..
  72. Chu D, DU M, Hu X, Wu Q, Shen J. Paeoniflorin attenuates schistosomiasis japonica-associated liver fibrosis through inhibiting alternative activation of macrophages. Parasitology. 2011;138:1259-71 pubmed publisher
    ..PAE might be a promising prophylactic agent for hepatic granuloma and fibrosis of schistosomiasis japonica.
  73. Burke M, McGarvey L, McSorley H, Bielefeldt Ohmann H, McManus D, Gobert G. Migrating Schistosoma japonicum schistosomula induce an innate immune response and wound healing in the murine lung. Mol Immunol. 2011;49:191-200 pubmed publisher
    ..These findings contribute to our understanding of host-parasite interactions associated with schistosome and, especially, S. japonicum infection, and may aid the future design of novel vaccines that target the lung stage schistosomulum...
  74. Qian C, Huang B, Yu C, Zhang J, Yin X, Wang J, et al. Detection of the circulating antigen 14-3-3 protein of Schistosoma japonicum by time-resolved fluoroimmunoassay in rabbits. Parasit Vectors. 2011;4:95 pubmed publisher
    ..In this study, a time-resolved fluoroimmunoassay (TRFIA) was developed for detecting the signal transduction protein 14-3-3, a circulating antigen of Schistosoma japonicum...
  75. Gray D, Williams G, Li Y, McManus D. Transmission dynamics of Schistosoma japonicum in the lakes and marshlands of China. PLoS ONE. 2008;3:e4058 pubmed publisher
    ..Unlike the disease caused by S. mansoni and S. haematobium, schistosomiasis japonica is a zoonosis, involving a number of different mammalian species as reservoir hosts...