fascioliasis

Summary

Summary: Liver disease caused by infections with parasitic flukes of the genus FASCIOLA, such as FASCIOLA HEPATICA.

Top Publications

  1. Rahimi M, Ashrafi K, Koosha S, Abdi J, Rokni M. Evaluation of Fast-ELISA versus standard-ELISA to diagnose human fasciolosis. Arch Iran Med. 2011;14:18-21 pubmed publisher
    ..2%, 100%, 94.6%, and 95.6% for both tests. Cut-off values, sensitivity, specificity, and other important parameters of the two evaluated tests determined that the F-ELISA method could be used with no detectable difference. ..
  2. Pointier J, Noya O, Alarcon de Noya B, Theron A. Distribution of Lymnaeidae (Mollusca: Pulmonata), intermediate snail hosts of Fasciola hepatica in Venezuela. Mem Inst Oswaldo Cruz. 2009;104:790-6 pubmed
    ..The role of these four lymnaeid species in the transmission of fascioliasis in Venezuela is discussed.
  3. Cantisani V, Cantisani C, Mortele K, Pagliara E, D Onofrio M, Fernandez M, et al. Diagnostic imaging in the study of human hepatobiliary fascioliasis. Radiol Med. 2010;115:83-92 pubmed publisher
    b>Fascioliasis is a rare zoonotic disease caused by the trematode Fasciola hepatica. We present the typical patterns of hepatobiliary fascioliasis observed in ten patients studied with multimodality imaging...
  4. Goral V, Senturk S, Mete O, Cicek M, Ebik B, Kaya B. A case of biliary Fascioliasis by Fasciola gigantica in Turkey. Korean J Parasitol. 2011;49:65-8 pubmed publisher
    ..She had the history of eating lettuce, mallow, dill, and parsley without washing. This is the first case of fascioliasis which was treated via endoscopic biliary extraction during ERCP in Turkey.
  5. McCann C, Baylis M, Williams D. The development of linear regression models using environmental variables to explain the spatial distribution of Fasciola hepatica infection in dairy herds in England and Wales. Int J Parasitol. 2010;40:1021-8 pubmed publisher
    ..The development of these detailed spatial models is the first step towards the development of a spatially specific, temporal forecasting system for liver fluke in the United Kingdom...
  6. Obchoei S, Weakley S, Wongkham S, Wongkham C, Sawanyawisuth K, Yao Q, et al. Cyclophilin A enhances cell proliferation and tumor growth of liver fluke-associated cholangiocarcinoma. Mol Cancer. 2011;10:102 pubmed publisher
    ..The ERK1/2 pathway may be involved in the CypA-mediated CCA cell proliferation. Thus, CypA may represent an important new therapeutic target for liver fluke-associated CCA. ..
  7. Nguyen T, Le T, Dao T, Tran T, Praet N, Speybroeck N, et al. Bovine fasciolosis in the human fasciolosis hyperendemic Binh Dinh province in Central Vietnam. Acta Trop. 2011;117:19-22 pubmed publisher
    ..It is concluded that a fasciolosis control programme should be designed in this region aiming at reducing infection in both cattle and humans...
  8. Amor N, Halajian A, Farjallah S, Merella P, Said K, Ben Slimane B. Molecular characterization of Fasciola spp. from the endemic area of northern Iran based on nuclear ribosomal DNA sequences. Exp Parasitol. 2011;128:196-204 pubmed publisher
    ..providing bases for further studies on F. hepatica, F. gigantica and their intermediate forms in the endemic areas in Asia. ..
  9. Rapsch C, Dahinden T, Heinzmann D, Torgerson P, Braun U, Deplazes P, et al. An interactive map to assess the potential spread of Lymnaea truncatula and the free-living stages of Fasciola hepatica in Switzerland. Vet Parasitol. 2008;154:242-9 pubmed publisher
    ..Extensive information on the free-living stages of F. hepatica and the intermediate host L. truncatula and how the development of these are affected by these environmental factors was used to create the interactive risk map. ..

More Information

Publications79

  1. Lopez M, White A, Cabada M. Burden of Fasciola hepatica Infection among children from Paucartambo in Cusco, Peru. Am J Trop Med Hyg. 2012;86:481-5 pubmed publisher
    There is a high prevalence of fascioliasis in the Peruvian highlands, but most cases remain undiagnosed. The burden of disease caused by chronic subclinical infection is largely unknown...
  2. Yesildag A, Senol A, Koroglu M, Kockar C, Oyar O, Isler M. Hepatobiliary fascioliasis: a case with unusual radiological features. Diagn Interv Radiol. 2010;16:299-301 pubmed publisher
    We report a case of hepatobiliary fascioliasis presenting with unusual radiological findings that have not been reported previously. Imaging studies revealed hepatic cystic pouches communicating with intrahepatic bile ducts...
  3. Issia L, Pietrokovsky S, Sousa Figueiredo J, Stothard J, Wisnivesky Colli C. Fasciola hepatica infections in livestock flock, guanacos and coypus in two wildlife reserves in Argentina. Vet Parasitol. 2009;165:341-4 pubmed publisher
    ..All snails (n=175) were Lymnaea truncatula and none of them was found infected. This is the first report of fascioliasis in free-ranging guanacos in Argentina. Coypu appears to be a major wildlife reservoir of F...
  4. Dowling D, Hamilton C, Donnelly S, La Course J, Brophy P, Dalton J, et al. Major secretory antigens of the helminth Fasciola hepatica activate a suppressive dendritic cell phenotype that attenuates Th17 cells but fails to activate Th2 immune responses. Infect Immun. 2010;78:793-801 pubmed publisher
    ..Therefore, both F. hepatica FhCL1 and FhGST-si modulate host immunity by suppressing responses associated with chronic inflammation-an immune modulatory mechanism that may benefit the parasite's survival within the host. ..
  5. González L, Esteban J, Bargues M, Valero M, Ortiz P, Naquira C, et al. Hyperendemic human fascioliasis in Andean valleys: an altitudinal transect analysis in children of Cajamarca province, Peru. Acta Trop. 2011;120:119-29 pubmed publisher
    ..Prevalences of fascioliasis ranging from 6.7 to 47.7% (mean 24.4%) proved to be the highest so far recorded in that human hyperendemic area...
  6. Charlier J, Bennema S, Caron Y, Counotte M, Ducheyne E, Hendrickx G, et al. Towards assessing fine-scale indicators for the spatial transmission risk of Fasciola hepatica in cattle. Geospat Health. 2011;5:239-45 pubmed
    ..hepatica at the individual farm level. Further research is needed to investigate how this knowledge can be incorporated in nation-wide spatial distribution models of the parasite...
  7. Khan M, Sajid M, Khan M, Iqbal Z, Arshad M, Hussain A. Point prevalence of bovine fascioliasis and the influence of chemotherapy on the milk yield in a lactating bovine population from the district of Toba Tek Singh, Pakistan. J Helminthol. 2011;85:334-8 pubmed publisher
    This paper provides an estimation of the point prevalence of fascioliasis and its economic impact in terms of increased milk yield after chemotherapy of a bovine population from the district of Toba Tek Singh, Punjab, Pakistan...
  8. Martins I, de Avelar B, Pereira M, da Fonseca A. Application of a geographical information system approach for risk analysis of fascioliasis in southern Espírito Santo state, Brazil. Geospat Health. 2012;6:S87-93 pubmed
    A model based on geographical information systems for mapping the risk of fascioliasis was developed for the southern part of Espírito Santo state, Brazil...
  9. Chunchob S, Grams R, Viyanant V, Smooker P, Vichasri Grams S. Comparative analysis of two fatty acid binding proteins from Fasciola gigantica. Parasitology. 2010;137:1805-17 pubmed publisher
    ..The results suggest differences in the biological functions of these 2 isoforms and differences in the host/parasite interaction that should be considered for their potential as vaccines against fascioliasis.
  10. McConville M, Brennan G, Flanagan A, Edgar H, Hanna R, McCoy M, et al. An evaluation of the efficacy of compound alpha and triclabendazole against two isolates of Fasciola hepatica. Vet Parasitol. 2009;162:75-88 pubmed publisher
    ..However, they reached the bile ducts more quickly and their eggs appeared in the faeces >2 weeks earlier...
  11. Keiser J, Rinaldi L, Veneziano V, Mezzino L, Tanner M, Utzinger J, et al. Efficacy and safety of artemether against a natural Fasciola hepatica infection in sheep. Parasitol Res. 2008;103:517-22 pubmed publisher
    ..Further studies are warranted to assess the potential of additional artemisinin derivatives and other peroxidic compounds for the treatment of Fasciola spp. infections in different ruminants...
  12. Jedlina L, Kozak Ljunggren M, Wedrychowicz H. In vivo studies of the early, peritoneal, cellular and free radical response in rats infected with Fasciola hepatica by flow cytometric analysis. Exp Parasitol. 2011;128:291-7 pubmed publisher
    ..Moreover juvenile flukes could stimulate the macrophages and neutrophils to generate H(2)O(2) radicals. The host parasite interactions resulting from immune response regulation by effector cells and immune evasion are discussed...
  13. Hawramy T, Saeed K, Qaradaghy S, Karboli T, Nore B, Bayati N. Sporadic incidence of Fascioliasis detected during hepatobiliary procedures: a study of 18 patients from Sulaimaniyah governorate. BMC Res Notes. 2012;5:691 pubmed publisher
    b>Fascioliasis is an often-neglected zoonotic disease and currently is an emerging infection in Iraq...
  14. Dar Y, Djuikwo T, Vignoles P, Dreyfuss G, Rondelaud D. Radix natalensis (Gastropoda: Lymnaeidae), a potential intermediate host of Fasciola hepatica in Egypt. Parasite. 2010;17:251-6 pubmed
    ..7/snail) during a mean patent period of 24.3 days. All snails have released these cercariae during 2-13 waves of shedding. According to these results, R. natalensis can be considered a potential intermediate host of F. hepatica in Egypt...
  15. Valero M, Perez Crespo I, Khoubbane M, Artigas P, Panova M, Ortiz P, et al. Fasciola hepatica phenotypic characterization in Andean human endemic areas: valley versus altiplanic patterns analysed in liver flukes from sheep from Cajamarca and Mantaro, Peru. Infect Genet Evol. 2012;12:403-10 pubmed publisher
    b>Fascioliasis is a zoonotic parasitic disease caused by Fasciola hepatica and Fasciola gigantica. Of both species, F...
  16. Valero M, Panova M, Perez Crespo I, Khoubbane M, Mas Coma S. Correlation between egg-shedding and uterus development in Fasciola hepatica human and animal isolates: applied implications. Vet Parasitol. 2011;183:79-86 pubmed publisher
    ..dpi) in a Wistar rat model with isolates obtained from cattle, sheep, pigs and humans from the endemic human fascioliasis zone of the Northern Bolivian Altiplano was analyzed and compared with the number of eggs shed per gram of ..
  17. Ai L, Chen M, Alasaad S, Elsheikha H, Li J, Li H, et al. Genetic characterization, species differentiation and detection of Fasciola spp. by molecular approaches. Parasit Vectors. 2011;4:101 pubmed publisher
    ..Herein, we provide an overview of the molecular techniques that are being used for the genetic characterization, detection and genotyping of Fasciola spp....
  18. Valero M, Periago M, Perez Crespo I, Angles R, Villegas F, Aguirre C, et al. Field evaluation of a coproantigen detection test for fascioliasis diagnosis and surveillance in human hyperendemic areas of Andean countries. PLoS Negl Trop Dis. 2012;6:e1812 pubmed publisher
    Emergence of human fascioliasis prompted a worldwide control initiative including a pilot study in a few countries...
  19. Fairweather I. Reducing the future threat from (liver) fluke: realistic prospect or quixotic fantasy?. Vet Parasitol. 2011;180:133-43 pubmed publisher
    ..Progress with the development of a number of new diagnostic tests will be reviewed...
  20. Nguyen T, van De N, Vercruysse J, Dorny P, Le T. Genotypic characterization and species identification of Fasciola spp. with implications regarding the isolates infecting goats in Vietnam. Exp Parasitol. 2009;123:354-61 pubmed publisher
    ..hepatica and F. gigantica in the goats/sheep in Vietnam, regardless of indigenous or imported hosts, appears to be the first demonstration from a tropical country...
  21. Rokni M, Mirhendi H, Mizani A, Mohebali M, Sharbatkhori M, Kia E, et al. Identification and differentiation of Fasciola hepatica and Fasciola gigantica using a simple PCR-restriction enzyme method. Exp Parasitol. 2010;124:209-13 pubmed publisher
    ..Our PCR-restriction enzyme profile is a simple, rapid and reliable method for differentiating F. hepatica and F. gigantica, and can be used for diagnostic and epidemiological purposes...
  22. Mezo M, González Warleta M, Castro Hermida J, Ubeira F. Evaluation of the flukicide treatment policy for dairy cattle in Galicia (NW Spain). Vet Parasitol. 2008;157:235-43 pubmed publisher
    ..Consequently, TCBZ should only be used to treat individual animals after correct diagnosis of the infection, and correct management measures taken to control re-infection...
  23. Mera y Sierra R, Agramunt V, Cuervo P, Mas Coma S. Human fascioliasis in Argentina: retrospective overview, critical analysis and baseline for future research. Parasit Vectors. 2011;4:104 pubmed publisher
    In Argentina, human fascioliasis has never been adequately analysed, although having a physiography, climate, animal prevalences and lymnaeids similar to those of countries where the disease is endemic such as Bolivia, Peru and Chile...
  24. Koc Z, Ulusan S, Tokmak N. Hepatobiliary fascioliasis: imaging characteristics with a new finding. Diagn Interv Radiol. 2009;15:247-51 pubmed publisher
    The aim of this study was to present the imaging characteristics of patients with hepatobiliary fascioliasis and describe a new imaging finding.
  25. Fox N, White P, McClean C, Marion G, Evans A, Hutchings M. Predicting impacts of climate change on Fasciola hepatica risk. PLoS ONE. 2011;6:e16126 pubmed publisher
    ..It can be used as a basis for indicating where active disease surveillance should be targeted and where the development of improved mitigation or adaptation measures is likely to bring the greatest benefits...
  26. Valero M, Perez Crespo I, Periago M, Khoubbane M, Mas Coma S. Fluke egg characteristics for the diagnosis of human and animal fascioliasis by Fasciola hepatica and F. gigantica. Acta Trop. 2009;111:150-9 pubmed publisher
    ..In fascioliasis, the usual diagnosis during the biliary stage of infection is based on the classification of eggs found in ..
  27. Muiño L, Perteguer M, Garate T, Martínez Sernández V, Beltran A, Romaris F, et al. Molecular and immunological characterization of Fasciola antigens recognized by the MM3 monoclonal antibody. Mol Biochem Parasitol. 2011;179:80-90 pubmed publisher
    b>Fascioliasis is a re-emerging parasitosis produced by liver flukes of the genus Fasciola. In this study we used protein fingerprinting (PMF) and MS/MS analysis to investigate the Fasciola secretory antigens that are recognized by mAb MM3...
  28. Lotfy W, Brant S, DeJong R, Le T, Demiaszkiewicz A, Rajapakse R, et al. Evolutionary origins, diversification, and biogeography of liver flukes (Digenea, Fasciolidae). Am J Trop Med Hyg. 2008;79:248-55 pubmed
    ..These flukes have been opportunistic, with respect to switching to new snail (planorbid to lymnaeid) and mammalian hosts and from intestinal to hepatic habitats within mammals...
  29. Piedrafita D, Spithill T, Smith R, Raadsma H. Improving animal and human health through understanding liver fluke immunology. Parasite Immunol. 2010;32:572-81 pubmed publisher
    ..Such studies are likely to boost the discovery of new vaccine, drug and diagnostic candidates and provide the foundation for future genetic selection of resistant animals...
  30. Fentie T, Erqou S, Gedefaw M, Desta A. Epidemiology of human fascioliasis and intestinal parasitosis among schoolchildren in Lake Tana Basin, northwest Ethiopia. Trans R Soc Trop Med Hyg. 2013;107:480-6 pubmed publisher
    ..Parasitic diseases are the second most frequent cause of outpatient morbidity in Ethiopia...
  31. Mezo M, Gonzalez Warleta M, Castro Hermida J, Muiño L, Ubeira F. Field evaluation of the MM3-SERO ELISA for detection of anti-Fasciola IgG antibodies in milk samples from individual cows and bulk milk tanks. Parasitol Int. 2010;59:610-5 pubmed publisher
    ..Use of the assay with bulk milk samples enables estimation of the within-herd prevalence of infection...
  32. Karahocagil M, Akdeniz H, Sunnetcioglu M, Cicek M, Mete R, Akman N, et al. A familial outbreak of fascioliasis in Eastern Anatolia: a report with review of literature. Acta Trop. 2011;118:177-83 pubmed publisher
    To present the results of a cross-sectional epidemiological analysis of a familial outbreak of fascioliasis in Eastern Anatolia and to discuss the clinical, diagnostic and therapeutic properties of the patients.
  33. Zhao Q, Vargas M, Dong Y, Zhou L, Wang X, Sriraghavan K, et al. Structure-activity relationship of an ozonide carboxylic acid (OZ78) against Fasciola hepatica. J Med Chem. 2010;53:4223-33 pubmed publisher
    ..This study also showed that the activity of 1 is peroxide-bond-dependent, suggesting that its flukicidal efficacy depends upon hemoglobin digestion in F. hepatica...
  34. Ai L, Dong S, Zhang W, Elsheikha H, Mahmmod Y, Lin R, et al. Specific PCR-based assays for the identification of Fasciola species: their development, evaluation and potential usefulness in prevalence surveys. Ann Trop Med Parasitol. 2010;104:65-72 pubmed publisher
    ..The developed PCR assays could provide useful tools for the detection, identification and epidemiological investigation of Fasciola infection in humans, other mammals and snails...
  35. Marcos L, Terashima A, Gotuzzo E. Update on hepatobiliary flukes: fascioliasis, opisthorchiasis and clonorchiasis. Curr Opin Infect Dis. 2008;21:523-30 pubmed publisher
    ..The present review focuses on current knowledge of clinical, diagnostic and treatment aspects caused by hepatobiliary flukes that can be applied to current protocols in endemic areas...
  36. El Shazly A, El Beshbishi S, Azab M, El Malky M, Abdeltawab A, Morsy A. Past and present situation of human fascioliasis in Dakahlia Governorate, Egypt. J Egypt Soc Parasitol. 2009;39:247-62 pubmed
    Zoonotic fascioliasis is a problem not only in Dakahlia Governorate, but also in other Egyptian Governorates. This work was conducted in ten centers at Dakahlia Governorate, Egypt...
  37. Fairweather I. Triclabendazole progress report, 2005-2009: an advancement of learning?. J Helminthol. 2009;83:139-50 pubmed publisher
    ..An update on the use of TCBZ for human fascioliasis is also given...
  38. Shu F, Lv R, Zhang Y, Duan G, Wu D, Li B, et al. Characterization of Fasciola samples by ITS of rDNA sequences revealed the existence of Fasciola hepatica and Fasciola gigantica in Yunnan Province, China. J Parasitol. 2012;98:889-90 pubmed publisher
    ..in this province...
  39. Mezo M, González Warleta M, Castro Hermida J, Muiño L, Ubeira F. Association between anti-F. hepatica antibody levels in milk and production losses in dairy cows. Vet Parasitol. 2011;180:237-42 pubmed publisher
    ..hepatica...
  40. Walker S, Johnston C, Hoey E, Fairweather I, Borgsteede F, Gaasenbeek C, et al. Potential role of hares in the spread of liver fluke in the Netherlands. Vet Parasitol. 2011;177:179-81 pubmed publisher
  41. McCann C, Baylis M, Williams D. Seroprevalence and spatial distribution of Fasciola hepatica-infected dairy herds in England and Wales. Vet Rec. 2010;166:612-7 pubmed publisher
    ..The highest prevalences of exposure were found in north-west England, where more than 47 per cent of herds were in the high positive exposure category...
  42. Sezgin O, Altintas E, Tombak A, Uçbılek E. Fasciola hepatica-induced acute pancreatitis: report of two cases and review of the literature. Turk J Gastroenterol. 2010;21:183-7 pubmed
    ..A high index of suspicion, specific ultrasonographic findings and eosinophilia are very helpful in the diagnosis of the disease...
  43. Donnelly S, Stack C, O Neill S, Sayed A, Williams D, Dalton J. Helminth 2-Cys peroxiredoxin drives Th2 responses through a mechanism involving alternatively activated macrophages. FASEB J. 2008;22:4022-32 pubmed publisher
    ..We propose that Prx activates macrophages as an initial step in the induction of Th2 responses by helminth parasites and is thereby a novel pathogen-associated molecular pattern...
  44. Valero M, Girones N, Garcia Bodelon M, Periago M, Chico Calero I, Khoubbane M, et al. Anaemia in advanced chronic fasciolosis. Acta Trop. 2008;108:35-43 pubmed publisher
    ..Extrapolation to human fasciolosis is discussed. The results of the rodent model lead to the assumption that a high risk of anaemia in subjects with a heavy parasitic burden in human hyperendemic areas of fasciolosis is to be expected...
  45. Valero M, Ubeira F, Khoubbane M, Artigas P, Muiño L, Mezo M, et al. MM3-ELISA evaluation of coproantigen release and serum antibody production in sheep experimentally infected with Fasciola hepatica and F. gigantica. Vet Parasitol. 2009;159:77-81 pubmed publisher
    ..the usefulness of the MM3-SERO and MM3-COPRO ELISAs as tools for the diagnosis of early as well as long-term fascioliasis infections, and suggest that they can potentially be applied to human fascioliasis even in countries where F...
  46. Itagaki T, Sakaguchi K, Terasaki K, Sasaki O, Yoshihara S, Van Dung T. Occurrence of spermic diploid and aspermic triploid forms of Fasciola in Vietnam and their molecular characterization based on nuclear and mitochondrial DNA. Parasitol Int. 2009;58:81-5 pubmed publisher
    ..Furthermore, the aspermic triploids seem to have originated in countries other than Vietnam and to have rapidly spread to that country with infected animals...
  47. Chen J, Chen M, Ai L, Xu X, Jiao J, Zhu T, et al. An Outbreak of Human Fascioliasis gigantica in Southwest China. PLoS ONE. 2013;8:e71520 pubmed publisher
    b>Fascioliasis is a common parasitic disease in livestock in China. However, human fascioliasis is rarely reported in the country. Here we describe an outbreak of human fascioliasis in Yunnan province...
  48. Bennema S, Ducheyne E, Vercruysse J, Claerebout E, Hendrickx G, Charlier J. Relative importance of management, meteorological and environmental factors in the spatial distribution of Fasciola hepatica in dairy cattle in a temperate climate zone. Int J Parasitol. 2011;41:225-33 pubmed publisher
    ..62. The results indicate that in temperate climate zones without large climatic and environmental variation, management factors affect the spatial distribution of F. hepatica, and should be included in future spatial distribution models...
  49. Sanchez Andrade A, Suárez J, Arias M, Francisco I, Diez C, Cortinas J, et al. Relationships between eosinophilia, anti-Fasciola IgG, and IgM rheumatoid factors, in urban and rural areas of north-western Spain. Ann Trop Med Parasitol. 2008;102:489-98 pubmed publisher
    ..Overall, 21% of the cases were found seropositive for fascioliasis and 15% were found to have IgM-RF...
  50. Cabada M, White A. New developments in epidemiology, diagnosis, and treatment of fascioliasis. Curr Opin Infect Dis. 2012;25:518-22 pubmed publisher
    This review focuses on the recent developments in the epidemiology, burden of disease, diagnostic tests, and treatment of fascioliasis.
  51. Jayaraj R, Piedrafita D, Dynon K, Grams R, Spithill T, Smooker P. Vaccination against fasciolosis by a multivalent vaccine of stage-specific antigens. Vet Parasitol. 2009;160:230-6 pubmed publisher
    ..Maximal protection of 83% was seen in the group vaccinated with cathepsin B and cathepsin L5 in combination...
  52. Mas Coma S, Valero M, Bargues M. Chapter 2. Fasciola, lymnaeids and human fascioliasis, with a global overview on disease transmission, epidemiology, evolutionary genetics, molecular epidemiology and control. Adv Parasitol. 2009;69:41-146 pubmed publisher
    b>Fascioliasis, caused by liver fluke species of the genus Fasciola, has always been well recognized because of its high veterinary impact but it has been among the most neglected diseases for decades with regard to human infection...
  53. Duthaler U, Smith T, Keiser J. In vivo and in vitro sensitivity of Fasciola hepatica to triclabendazole combined with artesunate, artemether, or OZ78. Antimicrob Agents Chemother. 2010;54:4596-604 pubmed publisher
    ..When combined, synergistic but also antagonistic effects depending on the doses administered were observed, which should be elucidated in more detail in future studies...
  54. Mera y Sierra R, Artigas P, Cuervo P, Deis E, Sidoti L, Mas Coma S, et al. Fascioliasis transmission by Lymnaea neotropica confirmed by nuclear rDNA and mtDNA sequencing in Argentina. Vet Parasitol. 2009;166:73-9 pubmed publisher
    b>Fascioliasis is widespread in livestock in Argentina...
  55. Rondelaud D, Hourdin P, Vignoles P, Dreyfuss G, Cabaret J. The detection of snail host habitats in liver fluke infected farms by use of plant indicators. Vet Parasitol. 2011;181:166-73 pubmed publisher
    ..The positive sites may be detected using a two-step method including first categorization of hydrographical zones and then, within a zone, use of one or several indicator plants (frequently J. acutiflorus)...
  56. Buffoni L, Zafra R, Pérez Ecija A, Martinez Moreno F, Martínez Galisteo E, Moreno T, et al. Immune response of goats immunised with glutathione S-transferase and experimentally challenged with Fasciola hepatica. Parasitol Int. 2010;59:147-53 pubmed publisher
    ..However, immunisation with FhGST induced the development of a well-defined immune response, characterized by the production of specific-FhGST antibodies as well as the appearance of circulating IL-4...
  57. Ozturhan H, Emekdas G, Sezgin O, Korkmaz M, Altintas E. Seroepidemiology of Fasciola Hepatica in Mersin province and surrounding towns and the role of family history of the Fascioliasis in the transmission of the parasite. Turk J Gastroenterol. 2009;20:198-203 pubmed
    b>Fascioliasis is an important zoonotic disease caused by Fasciola hepatica. This zoonosis may cause serious morbidity and a considerable financial burden...
  58. Yesildag A, Yildiz H, Demirci M, Goren I, Isler M. Biliary fascioliasis: sonographic appearance patterns. J Clin Ultrasound. 2009;37:26-30 pubmed publisher
    To describe the sonographic findings of biliary fascioliasis.
  59. Bernardo C, Carneiro M, Avelar B, Donatele D, Martins I, Pereira M. Prevalence of liver condemnation due to bovine fasciolosis in Southern Espírito Santo: temporal distribution and economic losses. Rev Bras Parasitol Vet. 2011;20:49-53 pubmed
    ..Condemnations occurred throughout the year, with the highest prevalence in April and May and with significant differences between the dry and wet seasons. The economic losses from liver condemnation can be considered high...
  60. Zafra R, Buffoni L, Martinez Moreno A, Pérez Ecija A, Martinez Moreno F, Perez J. A study of the liver of goats immunized with a synthetic peptide of the Sm14 antigen and challenged with Fasciola hepatica. J Comp Pathol. 2008;139:169-76 pubmed publisher
    ..A striking hepatic inflammatory infiltration of CD3+ T lymphocytes and IgG+ plasma cells was found in both groups 2 and 3, especially the latter...
  61. Nguyen T, Le T, De N, Doan T, Dao T, Vercruysse J, et al. Assessment of a 27-kDa antigen in enzyme-linked immunosorbent assay for the diagnosis of fasciolosis in Vietnamese patients. Trop Med Int Health. 2010;15:462-7 pubmed publisher
    ..This study demonstrated the diagnostic potential for human fasciolosis of the 27-kDa antigen ELISA. Fasciolosis should be considered in the differential diagnosis of hepatic disease in Vietnam...
  62. Howell A, Mugisha L, Davies J, LaCourse E, Claridge J, Williams D, et al. Bovine fasciolosis at increasing altitudes: parasitological and malacological sampling on the slopes of Mount Elgon, Uganda. Parasit Vectors. 2012;5:196 pubmed publisher
  63. Ong C, Subimerb C, Pairojkul C, Wongkham S, Cutcutache I, Yu W, et al. Exome sequencing of liver fluke-associated cholangiocarcinoma. Nat Genet. 2012;44:690-3 pubmed publisher
    ..This study provides insight into the mutational landscape contributing to O. viverrini-related CCA...
  64. Bennema S, Vercruysse J, Claerebout E, Schnieder T, Strube C, Ducheyne E, et al. The use of bulk-tank milk ELISAs to assess the spatial distribution of Fasciola hepatica, Ostertagia ostertagi and Dictyocaulus viviparus in dairy cattle in Flanders (Belgium). Vet Parasitol. 2009;165:51-7 pubmed publisher
    ..ostertagi were observed. D. viviparus infections were spread evenly over Flanders. Knowledge of locations of high risk areas can lead to increased awareness and may be the start of the development of regionally adapted control measures...
  65. Wilson R, Wright J, de Castro Borges W, Parker Manuel S, Dowle A, Ashton P, et al. Exploring the Fasciola hepatica tegument proteome. Int J Parasitol. 2011;41:1347-59 pubmed publisher
    ..This study demonstrates that components of the tegumental surface of F. hepatica can be defined using proteomic approaches, but also indicates the need to prevent vomiting if tegument secretions are to be characterised...
  66. Chinnasri P, Pairojkul C, Jearanaikoon P, Sripa B, Bhudhisawasdi V, Tantimavanich S, et al. Preferentially different mechanisms of inactivation of 9p21 gene cluster in liver fluke-related cholangiocarcinoma. Hum Pathol. 2009;40:817-26 pubmed publisher
  67. Mas Coma S, Valero M, Bargues M. Climate change effects on trematodiases, with emphasis on zoonotic fascioliasis and schistosomiasis. Vet Parasitol. 2009;163:264-80 pubmed publisher
    ..Secondly, important zoonotic diseases such as fascioliasis, schistosomiasis and cercarial dermatitis are analysed from the point of view of their relationships with ..
  68. Robinson M, Menon R, Donnelly S, Dalton J, Ranganathan S. An integrated transcriptomics and proteomics analysis of the secretome of the helminth pathogen Fasciola hepatica: proteins associated with invasion and infection of the mammalian host. Mol Cell Proteomics. 2009;8:1891-907 pubmed publisher
    ..hepatica are secreted into the parasite gut via a classical endoplasmic reticulum/Golgi pathway, we speculate that the antioxidants, which all lack a signal sequence, are released via a non-classical trans-tegumental pathway...
  69. Keiser J, Veneziano V, Rinaldi L, Mezzino L, Duthaler U, Cringoli G. Anthelmintic activity of artesunate against Fasciola hepatica in naturally infected sheep. Res Vet Sci. 2010;88:107-10 pubmed publisher
    ..3% and 83.9%, respectively, were calculated in the three surviving sheep. In conclusion, the interesting fasciocidal properties of artesunate in sheep warrant further investigations with an emphasis on toxicity studies...
  70. Ai L, Weng Y, Elsheikha H, Zhao G, Alasaad S, Chen J, et al. Genetic diversity and relatedness of Fasciola spp. isolates from different hosts and geographic regions revealed by analysis of mitochondrial DNA sequences. Vet Parasitol. 2011;181:329-34 pubmed publisher