strongylida infections

Summary

Summary: Infections with nematodes of the order STRONGYLIDA.

Top Publications

  1. McGarry J, Morgan E. Identification of first-stage larvae of metastrongyles from dogs. Vet Rec. 2009;165:258-61 pubmed
    ..The tails of the other species are described. A vasorum was significantly longer (mean [sd] 358.4 microm [10.28], range 334 to 380 microm) than the other species (range 229 to 281 microm). ..
  2. Luessi F, Sollors J, Torzewski M, Müller H, Siegel E, Blum J, et al. Eosinophilic meningitis due to Angiostrongylus cantonensis in Germany. J Travel Med. 2009;16:292-4 pubmed publisher
    ..After treatment with albendazole and corticosteroids he recovered completely...
  3. Traversa D, Milillo P, Di Cesare A, Lohr B, Iorio R, Pampurini F, et al. Efficacy and safety of emodepside 2.1%/praziquantel 8.6% spot-on formulation in the treatment of feline aelurostrongylosis. Parasitol Res. 2009;105 Suppl 1:S83-9 pubmed publisher
    ..Future practical perspectives in feline medicine and the major advantages of the spot-on product compared to the oral paste are discussed...
  4. Hoeve M, Mylonas K, Fairlie Clarke K, Mahajan S, Allen J, Graham A. Plasmodium chabaudi limits early Nippostrongylus brasiliensis-induced pulmonary immune activation and Th2 polarization in co-infected mice. BMC Immunol. 2009;10:60 pubmed publisher
    ..Co-infected animals received both infections on the same day, and disease was assessed daily before immunological measurements were taken at 3, 5, 7 or 20 days post-infection...
  5. Ferdushy T, Hasan M. Angiostrongylus vasorum: the 'French Heartworm'. Parasitol Res. 2010;107:765-71 pubmed publisher
    ..Therefore, this review will focus on the morphology, biology, clinical significant as well as management of this parasitic disease. ..
  6. Balic A, Smith K, Harcus Y, Maizels R. Dynamics of CD11c(+) dendritic cell subsets in lymph nodes draining the site of intestinal nematode infection. Immunol Lett. 2009;127:68-75 pubmed publisher
  7. Jefferies R, Vrhovec M, Wallner N, Catalan D. Aelurostrongylus abstrusus and Troglostrongylus sp. (Nematoda: Metastrongyloidea) infections in cats inhabiting Ibiza, Spain. Vet Parasitol. 2010;173:344-8 pubmed publisher
    ..Given the diversity of metastrongylid species capable of infecting cats, and morphological similarity of larval stages, an emphasis should be placed on the use of molecular characterisation for accurate diagnosis of infection...
  8. Harvie M, Camberis M, Tang S, Delahunt B, Paul W, Le Gros G. The lung is an important site for priming CD4 T-cell-mediated protective immunity against gastrointestinal helminth parasites. Infect Immun. 2010;78:3753-62 pubmed publisher
    ..In conclusion, vaccination strategies which seek to break the cycle of reinfection and egg production by helminths such as hookworms can include strategies which directly stimulate Th2 responses in the lung...
  9. Schnyder M, Tanner I, Webster P, Barutzki D, Deplazes P. An ELISA for sensitive and specific detection of circulating antigen of Angiostrongylus vasorum in serum samples of naturally and experimentally infected dogs. Vet Parasitol. 2011;179:152-8 pubmed publisher
    ..vasorum antigen by ELISA represents a valid alternative for reliable diagnosis and for follow-up investigations after anthelmintic treatment. Moreover, the test can be used for mass screening in large epidemiological investigations...

More Information

Publications81

  1. Tsai H, Huang Y, Liu Y, Wann S, Lee S, Chen E, et al. Dynamic changes of hepatocyte growth factor in eosinophilic meningitis caused by Angiostrongylus cantonensis infection. Am J Trop Med Hyg. 2009;80:980-2 pubmed
    ..These results indicate that high concentrations of HGF in the CSF occur in eosinophilic meningitis, and may have a role in protecting against endothelial injury and reducing BBB dysfunction. ..
  2. Wong S, Walker J, Jolin H, Drynan L, Hams E, Camelo A, et al. Transcription factor ROR? is critical for nuocyte development. Nat Immunol. 2012;13:229-36 pubmed publisher
    ..Notably, the transcription factor ROR? was critical for the development of nuocytes and their role in the expulsion of parasitic worms...
  3. Odiere M, Koski K, Weiler H, Scott M. Concurrent nematode infection and pregnancy induce physiological responses that impair linear growth in the murine foetus. Parasitology. 2010;137:991-1002 pubmed publisher
    ..Infection also reduced foetal crown-rump length which was associated with higher amniotic fluid IL-1 beta...
  4. Schnyder M, Fahrion A, Ossent P, Kohler L, Webster P, Heine J, et al. Larvicidal effect of imidacloprid/moxidectin spot-on solution in dogs experimentally inoculated with Angiostrongylus vasorum. Vet Parasitol. 2009;166:326-32 pubmed publisher
    ..vasorum in experimentally infected dogs and prevented patent infections. The earlier an infected dog was treated, the less severe were the pathological lesions observed in the lungs...
  5. Satoh T, Takeuchi O, Vandenbon A, Yasuda K, Tanaka Y, Kumagai Y, et al. The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection. Nat Immunol. 2010;11:936-44 pubmed publisher
    ..Collectively, these results show that Jmjd3-mediated H3K27 demethylation is crucial for regulating M2 macrophage development leading to anti-helminth host responses. ..
  6. Li Z, Liu G, Chen Y, Liu Y, Liu B, Su Z. The phenotype and function of naturally existing regulatory dendritic cells in nematode-infected mice. Int J Parasitol. 2011;41:1129-37 pubmed publisher
    ..The Treg cell responses and immunoregulatory cytokines induced by this regulatory DC subset in turn play an important role in mediation of the nematode-induced immunosuppression...
  7. Schucan A, Schnyder M, Tanner I, Barutzki D, Traversa D, Deplazes P. Detection of specific antibodies in dogs infected with Angiostrongylus vasorum. Vet Parasitol. 2012;185:216-24 pubmed publisher
    ..The early detection of specific antibodies against A. vasorum by ELISA represents a valid alternative for a reliable diagnosis and for follow-up investigations after anthelmintic treatment...
  8. Maizels R, Hewitson J, Murray J, Harcus Y, Dayer B, Filbey K, et al. Immune modulation and modulators in Heligmosomoides polygyrus infection. Exp Parasitol. 2012;132:76-89 pubmed publisher
    ..Proteomic and transcriptomic definition of parasite proteins, combined with biochemical identification of immunogenic molecules in resistant mice, will provide new candidate immunomodulators and vaccine antigens for future research...
  9. Traversa D, Di Cesare A, Milillo P, Lohr B, Iorio R, Pampurini F, et al. Efficacy and safety of imidacloprid 10%/moxidectin 1% spot-on formulation in the treatment of feline aelurostrongylosis. Parasitol Res. 2009;105 Suppl 1:S55-62 pubmed publisher
    ..Future practical perspectives in feline medicine and the major advantages of the spot-on product compared to the oral paste are discussed...
  10. Chen F, Liu Z, Wu W, Rozo C, Bowdridge S, Millman A, et al. An essential role for TH2-type responses in limiting acute tissue damage during experimental helminth infection. Nat Med. 2012;18:260-6 pubmed publisher
    ..These studies indicate an essential role for TH2-type immune responses in mediating acute wound healing during helminth infection. ..
  11. Lepri E, Veronesi F, Traversa D, Conti M, Marchesi M, Miglio A, et al. Disseminated angiostrongylosis with massive cardiac and cerebral involvement in a dog from Italy. Parasitol Res. 2011;109:505-8 pubmed publisher
    ..A. vasorum should be included among the differentials of dogs with cardiovascular and neurologic disease...
  12. Morassutti A, Levert K, Pinto P, da Silva A, Wilkins P, Graeff Teixeira C. Characterization of Angiostrongylus cantonensis excretory-secretory proteins as potential diagnostic targets. Exp Parasitol. 2012;130:26-31 pubmed publisher
    ..Molecular cloning of these respective targets will next be carried out to develop a panel of Angiostrongylus antigens that can be used for diagnostic purposes and to further study host-Angiostrongylus interactions...
  13. Wei P, Tsai C, Chiu P, Lai S. Matrix metalloproteinase-12 leads to elastin degradation in BALB/c mice with eosinophilic meningitis caused by Angiostrongylus cantonensis. Int J Parasitol. 2011;41:1175-83 pubmed publisher
    ..These results imply that MMP-12 contributes to the elastin degradation that occurs in angiostrongyliasis meningitis, and doxycycline can reverse related inflammatory events by inhibition of MMP-12...
  14. Chen R, Tong Q, Zhang Y, Lou D, Kong Q, Lv S, et al. Loop-mediated isothermal amplification: rapid detection of Angiostrongylus cantonensis infection in Pomacea canaliculata. Parasit Vectors. 2011;4:204 pubmed publisher
    ..However, the parasite is difficult to identify in snails. The purpose of this study was to develop a quick, simple molecular method to survey for A. cantonensis in intermediate host snails...
  15. Wang Q, Wu Z, Wei J, Owen R, Lun Z. Human Angiostrongylus cantonensis: an update. Eur J Clin Microbiol Infect Dis. 2012;31:389-95 pubmed publisher
    ..The most effective method for prevention is to persuade people not to eat raw or undercooked intermediate and paratenic hosts...
  16. Morgan E, Shaw S. Angiostrongylus vasorum infection in dogs: continuing spread and developments in diagnosis and treatment. J Small Anim Pract. 2010;51:616-21 pubmed publisher
    ..Understanding of the epidemiology and pathogenesis remains poor. This paper provides an overview of the current state of knowledge of this parasitic disease, focussing on the most recent developments and advances...
  17. Yasuda K, Muto T, Kawagoe T, Matsumoto M, Sasaki Y, Matsushita K, et al. Contribution of IL-33-activated type II innate lymphoid cells to pulmonary eosinophilia in intestinal nematode-infected mice. Proc Natl Acad Sci U S A. 2012;109:3451-6 pubmed publisher
    ..Finally, IL-33-stimulated NH cells induce lung eosinophilic inflammation and might aid to expel infected worms in the lungs...
  18. Wilson M, Taylor M, O Gorman M, Balic A, Barr T, Filbey K, et al. Helminth-induced CD19+CD23hi B cells modulate experimental allergic and autoimmune inflammation. Eur J Immunol. 2010;40:1682-96 pubmed publisher
    ..These data expand previous observations and highlight the broad regulatory environment that develops during helminth infections that can abate diverse inflammatory disorders in vivo...
  19. Reynolds L, Maizels R. Cutting edge: in the absence of TGF-? signaling in T cells, fewer CD103+ regulatory T cells develop, but exuberant IFN-? production renders mice more susceptible to helminth infection. J Immunol. 2012;189:1113-7 pubmed publisher
    ..Hence, overexpression of IFN-? negatively modulates immunity, and the presence of Helios(+) Tregs may maintain susceptibility on the C57BL/6 background. ..
  20. Traversa D, Di Cesare A, Meloni S, Frangipane di Regalbono A, Milillo P, Pampurini F, et al. Canine angiostrongylosis in Italy: occurrence of Angiostrongylus vasorum in dogs with compatible clinical pictures. Parasitol Res. 2013;112:2473-80 pubmed publisher
    ..Awareness among vet practitioners is discussed along with the importance of including A. vasorum on the list of differential diagnoses in canine clinical practice and of performing appropriate diagnostic methods...
  21. Li Z, Sun R, Li J, Song Y, Lin Y, Zeng X, et al. Efficacy of albendazole combined with a marine fungal extract (m2-9) against Angiostrongylus cantonensis-induced meningitis in mice. J Helminthol. 2012;86:410-7 pubmed publisher
    ..Therefore, m2-9 is a natural product with potentially significant therapeutic value for angiostrongyliasis and is worthy of further study...
  22. Al Sabi M, Deplazes P, Webster P, Willesen J, Davidson R, Kapel C. PCR detection of Angiostrongylus vasorum in faecal samples of dogs and foxes. Parasitol Res. 2010;107:135-40 pubmed publisher
  23. Chung L, Chen C, Wang L, Chang S, Yen C. Oxidative stress in mice infected with Angiostrongylus cantonensis coincides with enhanced glutathione-dependent enzymes activity. Exp Parasitol. 2010;126:178-83 pubmed publisher
    ..cantonensis during days 12-30 after infection due to ROS overproduction in CSF despite the increase in antioxidants during this period...
  24. Jones L, Houdijk J, Knox D, Kyriazakis I. Immunomodulatory effects of dietary protein during Nippostrongylus brasiliensis re-infection in lactating rats. Parasite Immunol. 2009;31:412-21 pubmed publisher
    ..Our study provides evidence that increased dietary protein content reduces the PPRI to N. brasiliensis re-infection in the lactating rat through improved mucosal immune responses...
  25. Lacorcia L, Gasser R, Anderson G, Beveridge I. Comparison of bronchoalveolar lavage fluid examination and other diagnostic techniques with the Baermann technique for detection of naturally occurring Aelurostrongylus abstrusus infection in cats. J Am Vet Med Assoc. 2009;235:43-9 pubmed publisher
  26. Gredal H, Willesen J, Jensen H, Nielsen O, Kristensen A, Koch J, et al. Acute neurological signs as the predominant clinical manifestation in four dogs with Angiostrongylus vasorum infections in Denmark. Acta Vet Scand. 2011;53:43 pubmed publisher
    ..This emphasises canine angiostrongylosis as a potential cause of fatal lesions of the central nervous system and the importance of including A. vasorum as a differential diagnosis in young dogs with acute neurological signs in Denmark...
  27. Dorta Contreras A, Padilla Docal B, Moreira J, Robles L, Aroca J, Alarcon F, et al. Neuroimmunological findings of Angiostrongylus cantonensis meningitis in Ecuadorian patients. Arq Neuropsiquiatr. 2011;69:466-9 pubmed
    ..Meningitis caused by Angiostrongylus cantonensis has recently been reported in patients resulting from the first outbreaks in subtropical regions of Ecuador...
  28. Grainger J, Smith K, Hewitson J, McSorley H, Harcus Y, Filbey K, et al. Helminth secretions induce de novo T cell Foxp3 expression and regulatory function through the TGF-? pathway. J Exp Med. 2010;207:2331-41 pubmed publisher
    ..We have therefore identified a novel pathway through which helminth parasites may stimulate T reg cells, which is likely to be a key part of the parasite's immunological relationship with the host...
  29. Morgan E, Jefferies R, Krajewski M, Ward P, Shaw S. Canine pulmonary angiostrongylosis: the influence of climate on parasite distribution. Parasitol Int. 2009;58:406-10 pubmed publisher
    ..g. by restricting movement of dogs unless tested or treated for A. vasorum, and monitored by focused surveillance of definitive and intermediate hosts. These efforts will benefit from newly developed diagnostic tests...
  30. Sullivan B, Liang H, Bando J, WU D, Cheng L, McKerrow J, et al. Genetic analysis of basophil function in vivo. Nat Immunol. 2011;12:527-35 pubmed publisher
    ..Although targeted deletion of IL-4 and IL-13 in either CD4(+) T cells or basophils had a minimal effect on worm clearance, deletion from both lineages demonstrated a nonredundant role for basophil cytokines in primary helminth immunity...
  31. Sawanyawisuth K, Takahashi K, Hoshuyama T, Sawanyawisuth K, Senthong V, Limpawattana P, et al. Clinical factors predictive of encephalitis caused by Angiostrongylus cantonensis. Am J Trop Med Hyg. 2009;81:698-701 pubmed publisher
    ..05; 95% CI, 1.59-862.35) were identified as statistically significant factors for EA prediction. Elderly patients with angiostrongyliasis experiencing fever and prolonged headaches were at the highest risk of developing EA...
  32. Conboy G. Canine angiostrongylosis: the French heartworm: an emerging threat in North America. Vet Parasitol. 2011;176:382-9 pubmed publisher
    ..Current treatment options include moxidectin, milbemycin oxime, and fenbendazole...
  33. Morimoto M, Utsumiya K. Enhanced protection against Heligmosomoides polygyrus in IL-2 receptor ?-chain overexpressed transgenic mice with intestinal mastocytosis. J Vet Med Sci. 2011;73:849-51 pubmed
    ..These results clearly indicated that mast cells have the ability for to protect against H. polygyrus infection. However, additional studies are required to evaluate protective effector mechanisms against H. polygyrus...
  34. Helm J, Gilleard J, Jackson M, Redman E, Bell R. A case of canine Angiostrongylus vasorum in Scotland confirmed by PCR and sequence analysis. J Small Anim Pract. 2009;50:255-9 pubmed publisher
    ..The use of this technique to definitively diagnose canine angiostrongylosis confirms the presence of this epidemiologically significant case. The implications of the changing distribution of this parasite are discussed...
  35. Kim S, Prout M, Ramshaw H, Lopez A, LeGros G, Min B. Cutting edge: basophils are transiently recruited into the draining lymph nodes during helminth infection via IL-3, but infection-induced Th2 immunity can develop without basophil lymph node recruitment or IL-3. J Immunol. 2010;184:1143-7 pubmed publisher
    ..Our results reveal a previously unknown role of IL-3 in recruiting basophils to the LN and demonstrate that basophils are not necessarily associated with the development of Th2 immunity during parasite infection...
  36. Hartmann S, Schnoeller C, Dahten A, Avagyan A, Rausch S, Lendner M, et al. Gastrointestinal nematode infection interferes with experimental allergic airway inflammation but not atopic dermatitis. Clin Exp Allergy. 2009;39:1585-96 pubmed publisher
  37. Diao Z, Chen X, Yin C, Wang J, Qi H, Ji A. Angiostrongylus cantonensis: effect of combination therapy with albendazole and dexamethasone on Th cytokine gene expression in PBMC from patients with eosinophilic meningitis. Exp Parasitol. 2009;123:1-5 pubmed publisher
    ..Combination therapy with albendazole and dexamethasone can shift the cytokine responses from Th2 to Th1 dominance, which may be a therapeutic mechanism...
  38. Liu Q, Kreider T, Bowdridge S, Liu Z, Song Y, Gaydo A, et al. B cells have distinct roles in host protection against different nematode parasites. J Immunol. 2010;184:5213-23 pubmed publisher
    ..This study suggests variability in the importance of B cells in mediating protection against intestinal nematode parasites, and it indicates an important role for Ab in resistance to tissue-dwelling parasites...
  39. Hewitson J, Filbey K, Grainger J, Dowle A, Pearson M, Murray J, et al. Heligmosomoides polygyrus elicits a dominant nonprotective antibody response directed against restricted glycan and peptide epitopes. J Immunol. 2011;187:4764-77 pubmed publisher
  40. McSorley H, O Gorman M, Blair N, Sutherland T, Filbey K, Maizels R. Suppression of type 2 immunity and allergic airway inflammation by secreted products of the helminth Heligmosomoides polygyrus. Eur J Immunol. 2012;42:2667-82 pubmed publisher
  41. Correale J, Farez M. The impact of parasite infections on the course of multiple sclerosis. J Neuroimmunol. 2011;233:6-11 pubmed publisher
    ..These new observations on parasite infections associated to MS indicate that parasite regulation of host immunity can alter the course of MS...
  42. Schnyder M, Schaper R, Pantchev N, Kowalska D, Szwedko A, Deplazes P. Serological detection of circulating Angiostrongylus vasorum antigen- and parasite-specific antibodies in dogs from Poland. Parasitol Res. 2013;112 Suppl 1:109-17 pubmed publisher
  43. Tetsutani K, Ishiwata K, Ishida H, Tu L, Torii M, Hamano S, et al. Concurrent infection with Heligmosomoides polygyrus suppresses anti-Plasmodium yoelii protection partially by induction of CD4(+)CD25(+)Foxp3(+) Treg in mice. Eur J Immunol. 2009;39:2822-30 pubmed publisher
    ..Our results suggest that intestinal nematodes moderate host immune responses during acute malaria infection by aggressive activation of Treg. Elucidation of the mechanisms of Treg activation in situ is a target for future analyses...
  44. Dennler M, Makara M, Kranjc A, Schnyder M, Ossent P, Deplazes P, et al. Thoracic computed tomography findings in dogs experimentally infected with Angiostrongylus vasorum. Vet Radiol Ultrasound. 2011;52:289-94 pubmed publisher
    ..CT allowed very detailed and accurate characterization of pulmonary parenchymal lesions, bronchi, and lymphnodes and closely reflected histopathological changes...
  45. Jefferies R, Morgan E, Helm J, Robinson M, Shaw S. Improved detection of canine Angiostrongylus vasorum infection using real-time PCR and indirect ELISA. Parasitol Res. 2011;109:1577-83 pubmed publisher
    ..Combined testing using real-time PCR and ELISA therefore improved the detection rate of A. vasorum infection and holds promise for improved clinical diagnosis and epidemiological investigation...
  46. Ince M, Elliott D, Setiawan T, Metwali A, Blum A, Chen H, et al. Role of T cell TGF-beta signaling in intestinal cytokine responses and helminthic immune modulation. Eur J Immunol. 2009;39:1870-8 pubmed publisher
    ..Thus, T cell TGF-beta signaling is essential for helminthic stimulation of mucosal IL-10 production, helminthic modulation of intestinal IFN-gamma generation and H. polygyrus-mediated suppression of chronic colitis...
  47. Luong L, Perkins S, Grear D, Rizzoli A, Hudson P. The relative importance of host characteristics and co-infection in generating variation in Heligmosomoides polygyrus fecundity. Parasitology. 2010;137:1003-12 pubmed publisher
    ..We concluded that intrinsic differences between hosts, specifically with regard to sex and breeding condition, contribute relatively more to the variation in worm fecundity than parasite co-infection status...
  48. Nielsen M, Vidyashankar A, Olsen S, Monrad J, Thamsborg S. Strongylus vulgaris associated with usage of selective therapy on Danish horse farms-is it reemerging?. Vet Parasitol. 2012;189:260-6 pubmed publisher
    ..vulgaris. This suggests that modifications of the parasite control programs could be considered on the studied farms, but it remains unknown to which extent this can be associated with increased health risks for infected horses...
  49. Neill D, Wong S, Bellosi A, Flynn R, Daly M, Langford T, et al. Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity. Nature. 2010;464:1367-70 pubmed publisher
    ..Thus, nuocytes represent a critically important innate effector cell in type-2 immunity...
  50. Herbst T, Esser J, Prati M, Kulagin M, Stettler R, Zaiss M, et al. Antibodies and IL-3 support helminth-induced basophil expansion. Proc Natl Acad Sci U S A. 2012;109:14954-9 pubmed publisher
    ..polygyrus bakeri, parasite rejection following challenge infection was impaired. These data reveal a role for isotype-switched antibodies in promoting basophil expansion and effector function following helminth infection. ..
  51. Smith K, Harcus Y, Garbi N, Hämmerling G, MacDonald A, Maizels R. Type 2 innate immunity in helminth infection is induced redundantly and acts autonomously following CD11c(+) cell depletion. Infect Immun. 2012;80:3481-9 pubmed publisher
    ..Thus, while CD11c(high) DCs initiate helminth-specific adaptive immunity, innate type 2 cells are able to mount an autonomous response to the challenge of parasite infection. ..
  52. Liang H, Reinhardt R, Bando J, Sullivan B, Ho I, Locksley R. Divergent expression patterns of IL-4 and IL-13 define unique functions in allergic immunity. Nat Immunol. 2011;13:58-66 pubmed publisher
    ..The distinct localization and cellular expression of IL-4 and IL-13 explains their unique roles during allergic immunity...
  53. Jefferies R, Morgan E, Shaw S. A SYBR green real-time PCR assay for the detection of the nematode Angiostrongylus vasorum in definitive and intermediate hosts. Vet Parasitol. 2009;166:112-8 pubmed publisher
    ..Real-time quantitative PCR offers a more efficient means of detecting A. vasorum infection with a lower limit of detection than traditional diagnostic tests, and it therefore has important clinical and epidemiological applications...
  54. Pipia A, Varcasia A, Tosciri G, Seu S, Manunta M, Mura M, et al. New insights onto cardiopulmonary nematodes of dogs in Sardinia, Italy. Parasitol Res. 2014;113:1505-9 pubmed publisher
    ..9% (61/684) to D. immitis. If on one side A. vasorum can be considered an emerging parasite in Sardinia, the parasitic pressure and the risk of infection for D. immitis in the island seems to be increased compared with the recent past...
  55. McWilliam H, Nisbet A, Dowdall S, Hodgkinson J, Matthews J. Identification and characterisation of an immunodiagnostic marker for cyathostomin developing stage larvae. Int J Parasitol. 2010;40:265-75 pubmed publisher
    ..A region of the gene encoding orthologous GALA sequences was isolated from 10 separate cyathostomin species, indicating the ubiquity of the protein in this nematode group...
  56. Knaus M, Kusi I, Rapti D, Xhaxhiu D, Winter R, Visser M, et al. Endoparasites of cats from the Tirana area and the first report on Aelurostrongylus abstrusus (Railliet, 1898) in Albania. Wien Klin Wochenschr. 2011;123 Suppl 1:31-5 pubmed publisher
    ..In conclusion, the prevalence of endoparasite infection in free-roaming cats in Tirana can be considered to be high. The occurrence of A. abstrusus, which may cause respiratory distress in cats, is reported for the first time in Albania...
  57. Schnyder M, Maurelli M, Morgoglione M, Kohler L, Deplazes P, Torgerson P, et al. Comparison of faecal techniques including FLOTAC for copromicroscopic detection of first stage larvae of Angiostrongylus vasorum. Parasitol Res. 2011;109:63-9 pubmed publisher
    ..vasorum in faecal samples, especially following transport or storage where there may be limited larvae viability, and larval migration techniques cannot be used...
  58. King I, Mohrs K, Mohrs M. A nonredundant role for IL-21 receptor signaling in plasma cell differentiation and protective type 2 immunity against gastrointestinal helminth infection. J Immunol. 2010;185:6138-45 pubmed publisher
    ..Our studies demonstrate a selective role for IL-21 in plasma cell differentiation in the context of protective antiparasitic type 2 immunity...
  59. Hang L, Setiawan T, Blum A, Urban J, Stoyanoff K, Arihiro S, et al. Heligmosomoides polygyrus infection can inhibit colitis through direct interaction with innate immunity. J Immunol. 2010;185:3184-9 pubmed publisher
    ..DCs have an important role in driving both murine and human IBD. Data suggest that phenotypic alternations in mucosal DC function are part of the regulatory process...
  60. Morgan E, Jefferies R, van Otterdijk L, McEniry R, Allen F, Bakewell M, et al. Angiostrongylus vasorum infection in dogs: Presentation and risk factors. Vet Parasitol. 2010;173:255-61 pubmed publisher
    ..Information on risk factors is useful in diagnosis and control, and forms a basis for further epidemiological investigation...
  61. Potian J, Rafi W, Bhatt K, McBride A, Gause W, Salgame P. Preexisting helminth infection induces inhibition of innate pulmonary anti-tuberculosis defense by engaging the IL-4 receptor pathway. J Exp Med. 2011;208:1863-74 pubmed publisher
    ..The Th2 response can thus enhance the intracellular persistence of Mtb, in part by mediating the alternative activation of macrophages via the IL-4R? signaling pathway...
  62. Helm J, Morgan E, Jackson M, Wotton P, Bell R. Canine angiostrongylosis: an emerging disease in Europe. J Vet Emerg Crit Care (San Antonio). 2010;20:98-109 pubmed publisher
    ..Apparent changes in the epidemiology of this unique parasite are considered, alongside information available regarding its recent geographic spread...
  63. Saenz S, Siracusa M, Perrigoue J, Spencer S, Urban J, Tocker J, et al. IL25 elicits a multipotent progenitor cell population that promotes T(H)2 cytokine responses. Nature. 2010;464:1362-6 pubmed publisher
  64. Hashimoto K, Uchikawa R, Tegoshi T, Takeda K, Yamada M, Arizono N. Immunity-mediated regulation of fecundity in the nematode Heligmosomoides polygyrus--the potential role of mast cells. Parasitology. 2010;137:881-7 pubmed publisher
    ..These findings raise the interesting possibility that certain activities of mast cells, either directly or indirectly, regulate parasite fecundity during infection...
  65. Kranjc A, Schnyder M, Dennler M, Fahrion A, Makara M, Ossent P, et al. Pulmonary artery thrombosis in experimental Angiostrongylus vasorum infection does not result in pulmonary hypertension and echocardiographic right ventricular changes. J Vet Intern Med. 2010;24:855-62 pubmed publisher
    ..Dogs experimentally inoculated with Angiostrongylus vasorum develop severe pulmonary parenchymal lesions and arterial thrombosis at the time of patency...
  66. Rausch S, Huehn J, Loddenkemper C, Hepworth M, Klotz C, Sparwasser T, et al. Establishment of nematode infection despite increased Th2 responses and immunopathology after selective depletion of Foxp3+ cells. Eur J Immunol. 2009;39:3066-77 pubmed publisher
  67. Massacand J, Stettler R, Meier R, Humphreys N, Grencis R, Marsland B, et al. Helminth products bypass the need for TSLP in Th2 immune responses by directly modulating dendritic cell function. Proc Natl Acad Sci U S A. 2009;106:13968-73 pubmed publisher
    ..Taken together, our data show that the primary function of TSLP is to directly suppress IL-12 secretion, thus supporting Th2 immune responses...
  68. Schnyder M, Deplazes P. Cross-reactions of sera from dogs infected with Angiostrongylus vasorum in commercially available Dirofilaria immitis test kits. Parasit Vectors. 2012;5:258 pubmed publisher
    ..For the detection of D. immitis infections, a variety of commercial tests have been developed, however, they have not been evaluated for cross-reactions against circulating antigens of A. vasorum...
  69. Barutzki D, Schaper R. Natural infections of Angiostrongylus vasorum and Crenosoma vulpis in dogs in Germany (2007-2009). Parasitol Res. 2009;105 Suppl 1:S39-48 pubmed publisher
    ..vulpis was detected at a time. 4 dogs were coinfected with A. vasorum and C. vulpis. These surprisingly high prevalence rates indicate that both parasites are endemic in Germany...
  70. Schnyder M, Fahrion A, Riond B, Ossent P, Webster P, Kranjc A, et al. Clinical, laboratory and pathological findings in dogs experimentally infected with Angiostrongylus vasorum. Parasitol Res. 2010;107:1471-80 pubmed publisher
    ..Infections starting from 50 L3 of A. vasorum had a massive impact on lung tissues and therefore on the health of affected dogs, particularly after prepatency, although only mild haematological abnormalities were evident...
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    ..Angiostrongylosis should be considered as one of the differential diagnoses in dogs presenting with neurologic signs consistent with acute intracranial haemorrhage...
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    ..brasiliensis. Collectively, these data provide strong evidence that ?? T cells play an important role in controlling infection with intestinal nematodes and limiting infection-induced pathology...