mansonelliasis

Summary

Summary: Infection with nematodes of the genus MANSONELLA. Symptoms include pruritus, headache, and articular swelling.

Top Publications

  1. Bregani E, Ceraldi T, Rovellini A, Ghiringhelli C. Case report: intraocular localization of Mansonella perstans in a patient from south Chad. Trans R Soc Trop Med Hyg. 2002;96:654 pubmed
    ..The symptoms and response to antifilarial treatment strongly suggested the intraocular localization of an M. perstans worm...
  2. Bregani E, Rovellini A, Tarsia P. Effects of thiabendazole in Mansonella perstans filariasis. Parassitologia. 2003;45:151-3 pubmed
    ..This study shows that thiabendazole may be effective in M. perstans infection. More studies are needed to determine a more effective dosage, or a putative combination treatment...
  3. Shelley A, Coscarón S. Simuliid blackflies (Diptera: Simuliidae) and ceratopogonid midges (Diptera: Ceratopogonidae) as vectors of Mansonella ozzardi (Nematoda: Onchocercidae) in northern Argentina. Mem Inst Oswaldo Cruz. 2001;96:451-8 pubmed
    ..ozzardi and both C. paraensis and S. exiguum secondary vectors. Additionally, it was found that a single dose of ivermectin was ineffectual in eradicating M. ozzardi from infected individuals in this area...
  4. Cohen J, Ribeiro J, Martins M. [Ocular manifestations in mansonelliasis]. Arq Bras Oftalmol. 2008;71:167-71 pubmed
    To evaluate eye manifestations in mansonelliasis patients from Coari, AM, rural area on the middle Amazonas River.
  5. Asio S, Simonsen P, Onapa A. Mansonella perstans filariasis in Uganda: patterns of microfilaraemia and clinical manifestations in two endemic communities. Trans R Soc Trop Med Hyg. 2009;103:266-73 pubmed publisher
    ..The observed patterns of microfilaraemia and the lack of obvious visible clinical manifestations suggest that the host's regulatory responses are downregulated in M. perstans infections. [ClinicalTrials.gov identifier: NCT00215280]...
  6. Krolewiecki A, Cajal S, Villalpando C, Gil J. Ivermectin-related adverse clinical events in patients treated for Mansonella ozzardi infections. Rev Argent Microbiol. 2011;43:48-50 pubmed publisher
    ..These reactions are well described in the treatment of other filarial infections, but have not yet been reported in the treatment of M. ozzardi. We are now reporting the first such known reactions with this helminthiasis...
  7. Bregani E, Rovellini A, Mbaïdoum N, Magnini M. Comparison of different anthelminthic drug regimens against Mansonella perstans filariasis. Trans R Soc Trop Med Hyg. 2006;100:458-63 pubmed
    ..Thiabendazole showed a small but significant activity against the infection. Combination treatments (DEC plus mebendazole) resulted in a significantly higher activity than the single drugs...
  8. Elliott A, Mawa P, Webb E, Nampijja M, Lyadda N, Bukusuba J, et al. Effects of maternal and infant co-infections, and of maternal immunisation, on the infant response to BCG and tetanus immunisation. Vaccine. 2010;29:247-55 pubmed publisher
    ..Effects of maternal immunisation on infant responses to vaccines should be explored. Prevention of infant malaria and HIV could contribute to effectiveness of immunisation programmes. ..
  9. Brown M, Kizza M, Watera C, Quigley M, Rowland S, Hughes P, et al. Helminth infection is not associated with faster progression of HIV disease in coinfected adults in Uganda. J Infect Dis. 2004;190:1869-79 pubmed
    ..We studied a cohort of human immunodeficiency virus (HIV)-infected adults in Uganda who were not receiving antiretroviral therapy, to explore the impact of helminths on HIV progression in areas where antiretrovirals are not available...

More Information

Publications109 found, 100 shown here

  1. Basano S, Medeiros J, Fontes G, Vieira G, Camargo J, Vera L, et al. Occurrence of Mansonella ozzardi diagnosed using a polycarbonate membrane in a riverside population of Lábrea in the Western Brazilian Amazon. Rev Soc Bras Med Trop. 2016;49:115-8 pubmed publisher
    ..001). The prevalence was higher in longer-term residents (?11 years; 60.2%). CONCLUSIONS M. ozzardi infection rates are high near the Purus River, much greater than those previously reported based on diagnosis using thick blood smears. ..
  2. Kiefer G, Battegay M, Gyr N, Hatz C. [Mansonella perstans filariasis after stay in Cameroon. A 19-year-old patient born in Cameroon, in Switzerland for the last 10 years]. Praxis (Bern 1994). 2002;91:61-6 pubmed
    ..A blood smear tested for presumed malaria showed subperiodic microfilariae of the species Mansonella perstans. The patient was treated with mebendazole (Vermox)...
  3. Asio S, Simonsen P, Onapa A. Analysis of the 24-h microfilarial periodicity of Mansonella perstans. Parasitol Res. 2009;104:945-8 pubmed publisher
    ..The observed weak pattern of mf periodicity indicates that the sampling time of blood specimens for diagnosis will have only minor effect on diagnostic sensitivity...
  4. Medeiros J, Py Daniel V, Barbosa U, Ogawa G. [Occurrence of Mansonella ozzardi (Nematoda, Onchocercidae) in riverine communities of the Purus river, Boca do Acre municipality, Amazonas State, Brazil]. Cad Saude Publica. 2009;25:1421-6 pubmed
    ..41 mf/40 microl), men (41.44 mf/40 microl), and farmers (49.94 mf/40 microl). Only the simuliid Cerqueirellum amazonicum was found infected with a parasitic infection rate of 0.98%...
  5. Tawill S, Kipp W, Lucius R, Gallin M, Erttmann K, Buttner D. Immunodiagnostic studies on Onchocerca volvulus and Mansonella perstans infections using a recombinant 33 kDa O. volvulus protein (Ov33). Trans R Soc Trop Med Hyg. 1995;89:51-4 pubmed
    ..Reaction with GST alone was minimal. The recombinant antigen Ov33 efficiently differentiates between O. volvulus and M. perstans infections, and is sensitive when used to detect patent and prepatent or low-level O. volvulus infections. ..
  6. Hillier S, Booth M, Muhangi L, Nkurunziza P, Khihembo M, Kakande M, et al. Plasmodium falciparum and helminth coinfection in a semi urban population of pregnant women in Uganda. J Infect Dis. 2008;198:920-7 pubmed publisher
    ..Recent studies suggest helminth infections may increase susceptibility to Plasmodium falciparum infection. If confirmed, this increased susceptibility could be particularly important during pregnancy-induced immunosuppression...
  7. Mpagi J, Buttner D, Tischendorf F, Erttmann K, Brattig N. Use of the recombinant Onchocerca volvulus protein Ov20/OvS1 for the immunodiagnostic differentiation between onchocerciasis and mansonelliasis and for the characterization of hyperreactive onchocerciasis (sowda). Trop Med Int Health. 2000;5:891-7 pubmed
    ..Ov20/OvS1 was used as antigen in ELISA and Western blot in order to differentiate onchocerciasis from African mansonelliasis and to characterize the hyperreactive form of Onchocerca volvulus infection (sowda)...
  8. Anosike J, Dozie I, Onwuliri C, Nwoke B, Onwuliri V. Prevalence of Mansonella perstans infections among the nomadic Fulanis of northern Nigeria. Ann Agric Environ Med. 2005;12:35-8 pubmed
    ..2 %) was the most prevalent while back pain (7.6 %) was the least. The findings show that mansonelliasis is an important health problem in nomads...
  9. van den Biggelaar A, Lopuhaa C, van Ree R, van der Zee J, Jans J, Hoek A, et al. The prevalence of parasite infestation and house dust mite sensitization in Gabonese schoolchildren. Int Arch Allergy Immunol. 2001;126:231-8 pubmed
    ..Chronic blood and tissue parasite infections that are often capable of modulating immune responses in the host are negatively associated with skin test reactivity in a sensitized population. ..
  10. Vera L, Basano S, Camargo J, França A, Ferreira R, Casseb A, et al. Improvement of a PCR test to diagnose infection by Mansonella ozzardi. Rev Soc Bras Med Trop. 2011;44:380-2 pubmed
    b>Mansonelliasis is caused by Mansonella ozzardi. It is widespread in the Amazon region, with a high prevalence...
  11. Basano S, Camargo J, Vera L, Velasques S, Ogawa G, Medeiros J, et al. Investigation of the occurrence of Mansonella ozzardi in the State of Rondônia, Western Amazonia, Brazil. Rev Soc Bras Med Trop. 2011;44:600-3 pubmed
    ..transmitted by Diptera Simuliidae flies (black flies), is widely spread in the Amazon, while the occurrence of mansonelliasis in the State of Rondônia (Western Amazonia) has not been reported thus far...
  12. Lansoud Soukate J, Gharib B, Baswaid S, Capron A, De Reggi M. Ecdysteroid-like compounds in the serum and urine of African patients infected with Loa loa and Mansonella perstans microfilariae. Trans R Soc Trop Med Hyg. 1990;84:269-71 pubmed
    ..Nevertheless, the most important point was that high ecdysteroid levels in man were always associated with a pathological condition. The precise significance of the phenomenon should be determined. ..
  13. McNeeley D, Raccurt C, Boncy J, Lowrie R. Clinical evaluation of Mansonella ozzardi in Haiti. Trop Med Parasitol. 1989;40:107-10 pubmed
    ..The microfilaria rate was significantly higher in certain occupations, but this was discounted as a risk factor for reasons that are explained. ..
  14. Onapa A, Simonsen P, Pedersen E, Okello D. Lymphatic filariasis in Uganda: baseline investigations in Lira, Soroti and Katakwi districts. Trans R Soc Trop Med Hyg. 2001;95:161-7 pubmed
    ..bancrofti infectivity rates of 1.1-1.7% and 1.3-2.9%, respectively. It is concluded that lymphatic filariasis is highly endemic in these high-altitude areas of Uganda, with An. gambiae s.l. and An. funestus being the main vectors. ..
  15. Grobusch M, Kombila M, Autenrieth I, Mehlhorn H, Kremsner P. No evidence of Wolbachia endosymbiosis with Loa loa and Mansonella perstans. Parasitol Res. 2003;90:405-8 pubmed
    ..perstans microfilariae. The absence of Wolbachia in both filarial species therefore discourages the use of antibiotics as an adjunct or alternative approach to current treatment concepts for both loiasis and mansonelliasis perstans.
  16. Crespo S, Palacios G, Scott S, Lago M, Puente S, Martinez M, et al. Abnormal depolarizing patterns in three patients with filarial infection. Ann Hematol. 2004;83:313-5 pubmed
    ..however that the erythrocyte-lysing agent used to facilitate leukocyte analysis by the instrument may have caused microfilaria fragmentation and thus the distinctive "straight-line" features of the abnormal scatter plots ..
  17. Uttah E, Etim S, Okonofua C, Effiom O. Endemic mansonellosis in Emohua local government area, Nigeria: human parasitaemia and Culicoides biting patterns. J Vector Borne Dis. 2011;48:41-5 pubmed
    ..Majority of those with positive microfilaraemia were poor socioeconomically, underscoring the need for health education and application of effective control measures against Culicoides biting midges in Emohua. ..
  18. Anosike J, Onwuliri C, Payne V, Amuta E, Akogun O, Adeiyongo C, et al. Observations on mansonellosis among the Ibos of Abia and Imo States, Nigeria. Angew Parasitol. 1992;33:235-41 pubmed
    ..Body itching was the most commonly observed clinical sign (14.7%), followed by joint pains (12.41%) with elephantoid scrotum (3.5%) as the least. The public health implication of the findings is discussed. ..
  19. Soro B, Rey J, Houdier R, Coulibaly A, Saki Z, Yao K, et al. [Pruritus after taking chloroquine and filariasis]. Bull Soc Pathol Exot Filiales. 1989;82:88-93 pubmed
    ..It is not possible to show an obvious relation between the presence of pruritus and the two filariasis. ..
  20. Gbakima A, Sahr F. Filariasis in the Kaiyamba Chiefdom, Moyamba District Sierra Leone: an epidemiological and clinical study. Public Health. 1996;110:169-74 pubmed
    ..5%) had ocular symptoms and 57(38.8%) had subcutaneous nodules. These data indicate that infections due to O. volvulus, W. bancrofti and M. perstans may be of public health importance in Sierra Leone. ..
  21. Bregani E, Ghiringhelli C, Ceraldi T, Rovellini A. Identification of Mansonella perstans microfilariae in ascitic fluid. Trop Doct. 2002;32:249-50 pubmed
  22. Semnani R, Mahapatra L, Dembele B, Konate S, Metenou S, Dolo H, et al. Expanded numbers of circulating myeloid dendritic cells in patent human filarial infection reflect lower CCR1 expression. J Immunol. 2010;185:6364-72 pubmed publisher
    ..These observations have major implications for regulation of immune responses to these long-lived parasites. ..
  23. Uni S, Bain O, Takaoka H. Affinities between Cutifilaria (Nematoda: Filarioidea), parasites of deer, and Mansonella as seen in a new onchocercid, M. (C.) perforata n. sp., from Japan. Parasite. 2004;11:131-40 pubmed
    ..In addition, almost all females had cuticular pores near the vulva, on the ventral line. The prevalence of microfiloriae and adults of M. (C.) perforata in the skin of sika deer was 38% and 21%, respectively...
  24. Kyelem D, Medlock J, Sanou S, Bonkoungou M, Boatin B, Molyneux D. Short communication: impact of long-term (14 years) bi-annual ivermectin treatment on Wuchereria bancrofti microfilaraemia. Trop Med Int Health. 2005;10:1002-4 pubmed
    ..Despite the long period of ivermectin treatment Mansonella perstans did not appear to respond to ivermectin in this setting...
  25. Pung O, Davis P, Richardson D. Filariae of raccoons from southeast Georgia. J Parasitol. 1996;82:849-51 pubmed
    ..This is the first record of filariae in raccoons from Georgia. In addition, Dirofilaria-like larvae were found in Aedes taeniorhyncus mosquitoes collected in Liberty County. ..
  26. Garrido C, Campos M. First report of presumed parasitic keratitis in Indians from the Brazilian Amazon. Cornea. 2000;19:817-9 pubmed
    ..None of the examined patients presented onchocercal-related skin lesions or positive skin biopsies for filaria. There was a significant association between mansonelliasis and keratitis.
  27. Agbolade M, Akinboye D. Loa loa and Mansonella perstans infections in Ijebu north, western Nigeria: a parasitological study. Jpn J Infect Dis. 2001;54:108-10 pubmed
    ..The geometric mean of the L. loa intensity was 1.8 mf per 50 microl of blood, while that of M. perstans was 1.5 mf per 50 microl. The prevalence of mixed infections of both L. loa and M. perstans was 1.0%...
  28. Pavlovic M, Berdat P, Holzer B, Aebi C, Carrel T, Pfammatter J. Severe mitral valve involvement in a child with hypereosinophilia secondary to parasitic infection. J Heart Valve Dis. 2003;12:649-51 pubmed
    ..In contrast to other microfilariae, M. perstans is non-pathogenic to humans; nevertheless, longstanding hypereosinophilia may lead to severe cardiac involvement endangering the patient's life...
  29. Marcos L, Arrospide N, Recuenco S, Cabezas C, Weil G, Fischer P. Genetic characterization of atypical Mansonella (Mansonella) ozzardi microfilariae in human blood samples from northeastern Peru. Am J Trop Med Hyg. 2012;87:491-4 pubmed publisher
    ..All atypical microfilariae were clustered into the Mansonella group and indistinguishable from M. ozzardi based on these DNA markers...
  30. Chadee D, Tilluckdharry C, Rawlins S, Doon R, Nathan M. Mass chemotherapy with diethylcarbamazine for the control of Bancroftian filariasis: a twelve-year follow-up in northern Trinidad, including observations on Mansonella ozzardi. Am J Trop Med Hyg. 1995;52:174-6 pubmed
    ..3% to 21.6% in 1980 and 1992. Nuclepore membrane filtration and thick blood films were very efficient in demonstrating the presence of microfilariae. The usefulness of these methods and spaced treatment using DEC-C are also discussed...
  31. Medeiros J, Costa C, Lima A, Pessoa F. Mansonella ozzardi (Nematoda: Onchocercidae) in the riverine population of the Tefé River, State of Amazonia, Brazil. Rev Soc Bras Med Trop. 2014;47:113-5 pubmed publisher
    ..This study assessed the prevalence of Mansonella ozzardi in riverine communities of the Tefé River, Amazonas, Brazil...
  32. Merino A, Bories C, Gantier J, Cardot P. Isolation of microfilariae from blood by gravitational field-flow fractionation. J Chromatogr. 1991;572:291-301 pubmed
    ..With both live and dead microfilariae, the high recovery (66-80%) allows preparative fractionation for diagnostic purposes or fundamental research. ..
  33. Mas J, Yumbe A, Sole N, Capote R, Cremades T. Prevalence, geographical distribution and clinical manifestations of onchocerciasis on the Island of Bioko (Equatorial Guinea). Trop Med Parasitol. 1995;46:13-8 pubmed
    ..8%). The results showed that onchocerciasis is hyperendemic and widespread over the island. It is estimated that almost the whole population (62,000) is at risk of infection...
  34. Fonticiella M, López Negrete L, Prieto A, García Hernández J, Orense M, Fernández Diego J, et al. Congenital intracranial filariasis: a case report. Pediatr Radiol. 1995;25:171-2 pubmed
    ..We present the case of a newborn with intracranial extra-axial collections which mere partially calcified. The underlying cause was shown to be filariasis which had been transmitted from the mother. ..
  35. Fischer P, Kilian A, Bamuhiiga J, Kipp W, Buttner D. Prevalence of Mansonella perstans in western Uganda and its detection using the QBC-fluorescence method. Appl Parasitol. 1996;37:32-7 pubmed
    ..perstans were detected. ..
  36. Jimenez M, Gonzalez L, Bailo B, Blanco A, García L, Pérez González F, et al. [Differential diagnosis of imported filariasis by molecular techniques (2006-2009)]. Enferm Infecc Microbiol Clin. 2011;29:666-71 pubmed publisher
    ..The results obtained were compared with those obtained using the conventional parasitological methods...
  37. Metenou S, Dembele B, Konate S, Dolo H, Coulibaly S, Coulibaly Y, et al. At homeostasis filarial infections have expanded adaptive T regulatory but not classical Th2 cells. J Immunol. 2010;184:5375-82 pubmed publisher
    ..Moreover, we have established baseline ex vivo frequencies of effector and Tregs at homeostasis at a population level. ..
  38. Medeiros J, Py Daniel V, Barbosa U. Prevalence of Mansonella ozzardi among riverine communities in the municipality of Lábrea, State of Amazonas, Brazil. Rev Soc Bras Med Trop. 2011;44:186-90 pubmed
    ..Estimate the prevalence of Mansonella ozzardi infection and calculate the parasitic infection rate (PIR) in simuliid black flies in the municipality of Lábrea, State of Amazonas, Brazil...
  39. Baird J, Neafie R, Connor D. Nodules in the conjunctiva, bung-eye, and bulge-eye in Africa caused by Mansonella perstans. Am J Trop Med Hyg. 1988;38:553-7 pubmed
    ..The morphologic features and histopathologic changes in the conjunctiva and periorbital fat are described and illustrated...
  40. Soboslay P, Geiger S, Weiss N, Banla M, Lüder C, Dreweck C, et al. The diverse expression of immunity in humans at distinct states of Onchocerca volvulus infection. Immunology. 1997;90:592-9 pubmed
    ..In onchocerciasis patients with concurrent mansonelliasis, cellular unresponsiveness to OvAg persisted, even when mf of O...
  41. Bregani E, Balzarini L, Ghiringhelli C, Tarsia P. Transfusional Mansonella perstans microfilariasis. Parassitologia. 2003;45:71-2 pubmed
    ..It is likely that only adult worms are responsible for symptoms and eosinophilia, whereas microfilariae in the bloodstream are unable to give clinical manifestations...
  42. Bregani E, Tantardini F, Rovellini A. Case report: effects of diethylcarbamazine and thiabendazole combination against Mansonella perstans filariasis. Parassitologia. 2007;49:37-8 pubmed
    ..The treatment was able to significantly reduce microfilaria burden in a case and to achieve complete clearance of blood microfilariae in another case. ..
  43. Medeiros J, Py Daniel V, Barbosa U, Ogawa G. Current profile of Mansonella ozzardi (Nematoda: Onchocercidae) in communities along the Ituxi river, Lábrea municipality, Amazonas, Brazil. Mem Inst Oswaldo Cruz. 2008;103:409-11 pubmed
  44. Simonsen P, Onapa A, Asio S. Mansonella perstans filariasis in Africa. Acta Trop. 2011;120 Suppl 1:S109-20 pubmed publisher
  45. Akogun O. Filariasis in Gongola State Nigeria. I: Clinical and parasitological studies in Mutum-Biyu District. Angew Parasitol. 1992;33:125-31 pubmed
    ..Dermatitis and hydrocoele were common and clinical manifestations were associated with parasite types. Clinical symptoms without microfilaremia and microfilaremia without clinical symptoms were also observed...
  46. Telford S, Forrester D. Hemoparasites of raccoons (Procyon lotor) in Florida. J Wildl Dis. 1991;27:486-90 pubmed
    ..Adult raccoons had a significantly greater prevalence of D. tenuis (32%) than did subadults and juveniles (7%), and male raccoons showed a significantly greater prevalence (51%) than did females (8%)...
  47. Ufomadu G, Nwoke B, Akoh J, Sato Y, Ekejindu G, Uchida A, et al. The occurrence of loiasis, mansonellosis and wuchereriasis in the Jarawa River Valley, central Nigeria. Acta Trop. 1990;48:137-47 pubmed
    ..8%) of all residents surveyed had clinical filariasis mainly due to lympho-obstructive manifestations: hydrocele (n = 11, 64.7%); enlargement of the inguinal nodes (n = 8, 47.1%) and elephantiasis (n = 2, 11.8%)...
  48. Anosike J, Onwuliri C. Studies on filariasis in Bauchi State, Nigeria. II. The prevalence of human filariasis in Darazo Local Government area. Appl Parasitol. 1994;35:242-50 pubmed
    ..05). Fishermen (42.9%), farmers (42.4%) and cattle rearers (40.9%) were the most affected occupational categories. Control strategies are highlighted...
  49. Gay F, Traore B, Zanoni J, Danis M, Gentilini M. [Evaluation of the QBC system for the diagnosis of malaria]. Sante. 1994;4:289-97 pubmed
  50. Soboslay P, Hamm D, Pfäfflin F, Fendt J, Banla M, Schulz Key H. Cytokine and chemokine responses in patients co-infected with Entamoeba histolytica/dispar, Necator americanus and Mansonella perstans and changes after anti-parasite treatment. Microbes Infect. 2006;8:238-47 pubmed
    ..The changes in this profile following anti-parasite therapy disclosed the dynamics of an immune adaptation associated with parasite accumulation and also with clearance of parasite infections...
  51. Fux C, Chappuis B, Holzer B, Aebi C, Bordmann G, Marti H, et al. Mansonella perstans causing symptomatic hypereosinophilia in a missionary family. Travel Med Infect Dis. 2006;4:275-80 pubmed
    ..Pathogenicity may be related to the induction of hypereosinophilia rather than direct host-parasite interactions...
  52. Bregani E, Balzarini L, Mbaïdoum N, Rovellini A. Prevalence of filariasis in symptomatic patients in Moyen Chari district, south of Chad. Trop Doct. 2007;37:175-7 pubmed
    ..No relationship was observed between eosinophils and symptoms. The prevalence observed in symptomatic patients could reflect the real prevalence of filariasis...
  53. Asio S, Simonsen P, Onapa A. Mansonella perstans: safety and efficacy of ivermectin alone, albendazole alone and the two drugs in combination. Ann Trop Med Parasitol. 2009;103:31-7 pubmed publisher
    ..The three single-dose drug regimens investigated were thus well tolerated but had disappointingly low efficacies in the treatment of M. perstans microfilaraemias...
  54. Hoerauf A. Mansonella perstans--the importance of an endosymbiont. N Engl J Med. 2009;361:1502-4 pubmed publisher
  55. Vila Montlleo R. [Serum filariasis due to Loa loa and Mansonella perstans in the continental area of equatorial Guinea. Preliminary results]. Med Trop (Mars). 1990;50:399-402 pubmed
    ..1 p.c. for Loa-Loa and 66.3 p.c. for Mansonella perstans. Significant differences were noted in the prevalence and in the mean density of microfilariae of both species according to the altitude of the villages surveyed...
  56. Richard Lenoble D, Kombila M, Chandenier J, Gaxotte P. [The efficacy and tolerance of ivermectin (Mectizan) prescribed for the patient with multiple filarial infections (Loa loa/Onchocerca and/or M. perstans)]. Bull Soc Pathol Exot Filiales. 1989;82:65-71 pubmed
    ..Efficacy on Ascaris lumbricoides appears to be excellent; further studies are necessary in the cases of trichuriasis, ancylostomiasis and strongyloidiasis...
  57. Udonsi J. Filariasis in the Igwun River Basin, Nigeria: an epidemiological and clinical study with a note on the vectors. Ann Trop Med Parasitol. 1988;82:75-82 pubmed
    ..5% showed ocular manifestations. The absence of blindness despite high O. volvulus infection rates was remarkable. The presence of potential insect vectors and the occurrence of clinical signs are indications of active transmissions...
  58. Shelley A, Dias A, Maia Herzog M, Procunier W, Moraes M. Identification of vector species (Diptera:Simuliidae) of human onchocerciasis in the amazonia focus of Brazil and Venezuela. Mem Inst Oswaldo Cruz. 1987;82:461-5 pubmed
    ..oyapockense, and S. yarzabali is revalidated from its synonymy with S. incrustatum Lutz. The role of these three species in the transmission of human onchocerciasis and mansonelliasis in Amazonia is reviewed.
  59. Useh M, Ejezie G. The status and consequences of Mansonella perstans infection in Calabar, Nigeria. East Afr Med J. 1995;72:124-6 pubmed
    ..perstans in the different ages treated (p > 0.01) while non existed by sex (p > 0.01). The possible involvement of M. perstans in ocular filariasis and its treatment are discussed...
  60. Schulz Key H, Albrecht W, Heuschkel C, Soboslay P, Banla M, Gorgen H. Efficacy of ivermectin in the treatment of concomitant Mansonella perstans infections in onchocerciasis patients. Trans R Soc Trop Med Hyg. 1993;87:227-9 pubmed
    ..ivermectin dose-ranging study of onchocerciasis patients in Togo, 55 onchocerciasis patients with concomitant mansonelliasis received single oral doses either of ivermectin (100 to 200 micrograms/kg body weight) or placebo...
  61. Van den Enden E, Van Gompel A, Van der Stuyft P, Vervoort T, van den Ende J. Treatment failure of a single high dose of ivermectin for Mansonella perstans filariasis. Trans R Soc Trop Med Hyg. 1993;87:90 pubmed
    ..We evaluated the effect of a single high dose of ivermectin (600 micrograms/kg) on microfilaraemia in 7 consecutive patients. No decrease in microfilarial counts could be demonstrated after a follow-up period of 7-56 d...
  62. Goverde A, Schats R, van Berlo P, Claessen F. An unexpected guest in follicular fluid. Hum Reprod. 1996;11:531-2 pubmed
  63. Bartoloni A, Cancrini G, Bartalesi F, Marcolin D, Roselli M, Arce C, et al. Mansonella ozzardi infection in Bolivia: prevalence and clinical associations in the Chaco region. Am J Trop Med Hyg. 1999;61:830-3 pubmed
    ..No significant association between clinical symptoms (fever, skin rash, pruritus, headache, lymphedema, elephantiasis, and articular pain) and microfilaremia was observed...
  64. Fumiya S, Chongsvivatwong V, Saburo U, Thammapalo S. The feasibility of a bed net impregnation program to enhance control of Malayan filariasis along a swamp forest in southern Thailand. Southeast Asian J Trop Med Public Health. 2001;32:235-9 pubmed
    ..The impregnation program was potentially welcome by both groups of villagers. From this study, we conclude that a bed net impregnation program in this area is feasible...
  65. Bregani E, Tantardini F, Rovellini A. [Mansonella perstans filariasis]. Parassitologia. 2007;49:23-6 pubmed
    ..Thiabendazole evidenced a small, but significant activity against the infection. Combination treatments (DEC plus mebendazole) resulted in a significantly higher activity compared with the single drugs...
  66. Noireau F, Pichon G. Population dynamics of Loa loa and Mansonella perstans infections in individuals living in an endemic area of the Congo. Am J Trop Med Hyg. 1992;46:672-6 pubmed
    ..At the individual level, the microfilarial densities of L. loa and M. perstans also remained remarkably constant over time. This results in a qualitative and quantitative stability of the parasitic material available for the vectors...
  67. Nutman T. Experimental infection of humans with filariae. Rev Infect Dis. 1991;13:1018-22 pubmed
  68. Lastre M, Perez O, Cordovi R. [A group of African students parasitized with Mansonella perstans in Cuba (a non-endemic area) from 1979 to 1982]. Rev Cubana Med Trop. 1990;42:203-7 pubmed
  69. Formica S, Botto C. Filariasis focus due to Mansonella ozzardi and Mansonella perstans in the Amazon Federal Territory of Venezuela. J Trop Med Hyg. 1990;93:160-5 pubmed
    ..perstans and varied between 1 and 327 microfilariae per ml. This paper presents for the first time the presence of a transmission focus of M. perstans in the Amazon Federal Territory and confirms the finding of M. ozzardi in the region...
  70. Mommers E, Dekker H, Richard P, Garica A, Chippaux J. Prevalence of L. loa and M. perstans filariasis in southern Cameroon. Trop Geogr Med. 1995;47:2-5 pubmed
    ..Both prevalence and density were increasing with age and were higher for men than for women. The time of day that the blood sample was taken had no influence on the microfilarial density of M. perstans...
  71. Fischer P, Bamuhiiga J, Buttner D. Treatment of human Mansonella streptocerca infection with ivermectin. Trop Med Int Health. 1997;2:191-9 pubmed
    ..streptocerca. Common adverse effects were increased pruritus and acute papular dermatitis in 45% of 86 mf carriers on day 6 after treatment. No serious adverse side-effects were noticed in about 700 treated persons...
  72. Fischer P, Tukesiga E, Buttner D. Long-term suppression of Mansonella streptocerca microfilariae after treatment with ivermectin. J Infect Dis. 1999;180:1403-5 pubmed
    ..Because these filarial parasites are often coendemic with M. streptocerca, the treated population may receive the additional benefit of suppression of M. streptocerca microfilariae...
  73. Mai C, Hamm D, Banla M, Agossou A, Schulz Key H, Heuschkel C, et al. Onchocerca volvulus-specific antibody and cytokine responses in onchocerciasis patients after 16 years of repeated ivermectin therapy. Clin Exp Immunol. 2007;147:504-12 pubmed
    ..Such deficient reconstitution of immune competence may be due to an as yet continuing and uncontrolled reinfection with O. volvulus, but parasite co-infections can also bias and may prevent the development of such immunity...
  74. Coulibaly Y, Dembele B, Diallo A, Lipner E, Doumbia S, Coulibaly S, et al. A randomized trial of doxycycline for Mansonella perstans infection. N Engl J Med. 2009;361:1448-58 pubmed publisher
    ..perstans is refractory to standard antifilarial therapies. The recent discovery of bacterial endosymbionts (e.g., wolbachia) in most filarial species, including M. perstans, provides new therapeutic options for reducing microfilaremia...
  75. Jimenez M, Gonzalez L, Carranza C, Bailo B, Pérez Ayala A, Muro A, et al. Detection and discrimination of Loa loa, Mansonella perstans and Wuchereria bancrofti by PCR-RFLP and nested-PCR of ribosomal DNA ITS1 region. Exp Parasitol. 2011;127:282-6 pubmed publisher
    ..These filarial species-specific molecular protocols were evaluated in forty blood samples from African adult immigrants attending in the Hospital Insular of Gran Canaria, Canarias, Spain...
  76. Degese M, Cabrera M, Krivokapich S, Irazu L, Rodríguez M, Guarnera E. [Contribution of the PCR assay to the diagnosis of Mansonella ozzardi in endemic areas of Argentina]. Rev Argent Microbiol. 2012;44:97-100 pubmed
    Mansonella ozzardi is a tissue-dwelling parasitic nematode, the causative agent of mansonelliasis in almost all Latin American countries. It has been described along the Argentine Yungas region...
  77. Medrano C, Volcan G, Godoy G. [Mansonelliasis in the southeast Venezuelan Orinoquia region]. Rev Inst Med Trop Sao Paulo. 1992;34:61-70 pubmed
    ..three Indians and an inhabitant of mixed blood from 13 different communities were found to be infected with mansonelliasis representing a global index of 36.40% in the endemic area...
  78. Mavoungou D, Lansoud Soukate J, Dupont A. Steroid and gonadotropin hormone levels in young African women with filarial infection. J Steroid Biochem. 1989;34:577-80 pubmed
    ..Microfilaremia should therefore be considered an environmental factor which mediates endocrine disorders in subjects living in tropical filariasis areas...
  79. Van Hoegaerden M, Ivanoff B, Flocard F, Salle A, Chabaud B. The use of mebendazole in the treatment of filariases due to Loa loa and Mansonella perstans. Ann Trop Med Parasitol. 1987;81:275-82 pubmed
    ..Mebendazole may consequently be regarded as a safer alternative to diethylcarbamazine for the treatment of these two parasitoses...
  80. Baird J, Neafie R, Lanoie L, Connor D. Adult Mansonella perstans in the abdominal cavity in nine Africans. Am J Trop Med Hyg. 1987;37:578-84 pubmed
    ..The diameter of male worms was 45 microns to 60 microns and of female worms, 80 microns to 125 microns. One female worm was removed intact. It was 6 cm long and had a bifurcated tail characteristic of M. perstans...
  81. Anosike J. The status of human filariasis in north-western zone of Bauchi State, Nigeria. Appl Parasitol. 1994;35:133-40 pubmed
    ..01). Fishermen, nomads and farmers had significantly higher infection rates (P < 0.05) than other occupational categories. Suggestions on the disease intervention involving treatment, prevention and vector control are highlighted...
  82. Gomez J, Guerrero R. Environmental factors and the distribution of mansonelliases in southern Venezuela. Parasite. 2000;7:71-6 pubmed
    ..ozzardi in semideciduous forest of the alisio type. Therefore two types of transmission, M. ozzardi-Simulium and M. perstans-Culicoides are suggested...
  83. Wanji S, Tendongfor N, Esum M, Ndindeng S, Enyong P. Epidemiology of concomitant infections due to Loa loa, Mansonella perstans, and Onchocerca volvulus in rain forest villages of Cameroon. Med Microbiol Immunol. 2003;192:15-21 pubmed
    ..perstans and O. volvulus. The implications of the co-occurrence of the three species of filariae in the populations of these remote villages on the intervention programs based on mass treatment with mectizan are discussed...
  84. Noireau F, Itoua A, Carme B. Epidemiology of Mansonella perstans filariasis in the forest region of south Congo. Ann Trop Med Parasitol. 1990;84:251-4 pubmed
    ..grahamii, and 0.8% of these were infected with filarial larvae. Two other species of Culicoides (C. kumbaensis and C. rutshuruensis) might also play a role in the transmission of M. perstans...
  85. Noireau F, Apembet J. Comparison of thick blood smear and saponin haemolysis for the detection of Loa loa and Mansonella perstans infections. J Trop Med Hyg. 1990;93:390-2 pubmed
    ..5 for L. loa and 1.6 for M. perstans. In addition, the analysis of a large volume of blood provides a better estimation of microfilarial load of the parasitized population...
  86. Lansoud Soukate J, Dupont A, De Reggi M, Roelants G, Capron A. Hypogonadism and ecdysteroid production in Loa loa and Mansonella perstans filariasis. Acta Trop. 1989;46:249-56 pubmed
    ..A direct role for parasitic ecdysteroids in hypogonadism remains to be demonstrated...
  87. Richard Lenoble D, Kombila M, Rupp E, Pappayliou E, Gaxotte P, Nguiri C, et al. Ivermectin in loiasis and concomitant O. volvulus and M. perstans infections. Am J Trop Med Hyg. 1988;39:480-3 pubmed
    ..All patients tolerated ivermectin well including those with multiple infections...
  88. Anosike J. Studies on filariasis in Bauchi State, Nigeria. V. The distribution and prevalence of mansonellosis with special reference to clinical signs. Appl Parasitol. 1994;35:189-92 pubmed
    ..05). Clinical signs observed include pruritus, rash, inguinal adenopathy and occasional dizziness. Skin biopsies taken from the shoulder gave the highest frequency of positive skin snip...
  89. Fischer P, Bamuhiiga J, Buttner D. Occurrence and diagnosis of Mansonella streptocerca in Uganda. Acta Trop. 1997;63:43-55 pubmed
    ..An itching acute or more often chronic papular dermatitis, predominantly on the upper parts of the body, was the typical skin lesion observed in 24% of 177 M. streptocerca mf carriers...
  90. Morales Hojas R, Post R, Shelley A, Maia Herzog M, Coscarón S, Cheke R. Characterisation of nuclear ribosomal DNA sequences from Onchocerca volvulus and Mansonella ozzardi (Nematoda: Filarioidea) and development of a PCR-based method for their detection in skin biopsies. Int J Parasitol. 2001;31:169-77 pubmed
    ..ozzardi than the parasitological examination of blood. No infection with O. volvulus was detected by PCR. This PCR-based assay may assist in determining the nature of infection in areas where both filarial species exist in sympatry...
  91. Onapa A, Simonsen P, Baehr I, Pedersen E. Rapid assessment of the geographical distribution of Mansonella perstans infections in Uganda, by screening schoolchildren for microfilariae. Ann Trop Med Parasitol. 2005;99:383-93 pubmed
    ..More attention needs to be paid to the public-health implications of this wide-spread but neglected infection...
  92. Martins M, Pessoa F, de Medeiros M, de Andrade E, Medeiros J. Mansonella ozzardi in Amazonas, Brazil: prevalence and distribution in the municipality of Coari, in the middle Solimões River. Mem Inst Oswaldo Cruz. 2010;105:246-53 pubmed
    ..M. ozzardi is a widely distributed parasitic disease in Coari. Thus, temporary residency in the region of people from other localities involved with the local gas exploitation might be a contributing factor in spreading the disease...