helminthiasis

Summary

Summary: Infestation with parasitic worms of the helminth class.

Top Publications

  1. Pullan R, Gething P, Smith J, Mwandawiro C, Sturrock H, Gitonga C, et al. Spatial modelling of soil-transmitted helminth infections in Kenya: a disease control planning tool. PLoS Negl Trop Dis. 2011;5:e958 pubmed publisher
    ..As control is successful in reducing infection levels, updated models can be used to refine decision making in helminth control. ..
  2. Jia T, Melville S, Utzinger J, King C, Zhou X. Soil-transmitted helminth reinfection after drug treatment: a systematic review and meta-analysis. PLoS Negl Trop Dis. 2012;6:e1621 pubmed publisher
    ..This strategy, however, does not prevent reinfection. We performed a systematic review and meta-analysis to assess patterns and dynamics of STH reinfection after drug treatment...
  3. Hodges M, Dada N, Wamsley A, Paye J, Nyorkor E, Sonnie M, et al. Improved mapping strategy to better inform policy on the control of schistosomiasis and soil-transmitted helminthiasis in Sierra Leone. Parasit Vectors. 2011;4:97 pubmed publisher
    Schistosomiasis and soil-transmitted helminthiasis (STH) are endemic in Sierra Leone confirmed by national mapping in 2008...
  4. Yajima A, Gabrielli A, Montresor A, Engels D. Moderate and high endemicity of schistosomiasis is a predictor of the endemicity of soil-transmitted helminthiasis: a systematic review. Trans R Soc Trop Med Hyg. 2011;105:68-73 pubmed publisher
    ..a systematic literature review with the following aims: to investigate how frequently soil-transmitted helminthiasis (STH) infections are endemic where schistosomiasis is present; and to assess the correlation between the risk ..
  5. Boatin B, Basanez M, Prichard R, Awadzi K, Barakat R, Garcia H, et al. A research agenda for helminth diseases of humans: towards control and elimination. PLoS Negl Trop Dis. 2012;6:e1547 pubmed publisher
    ..quot; ..
  6. Smith K, Hochweller K, Hämmerling G, Boon L, MacDonald A, Maizels R. Chronic helminth infection promotes immune regulation in vivo through dominance of CD11cloCD103- dendritic cells. J Immunol. 2011;186:7098-109 pubmed publisher
    ..Thus, the proregulatory environment of chronic intestinal helminth infection is associated with the in vivo predominance of a newly defined phenotype of CD11c(lo) tolerogenic DCs. ..
  7. Hodges M, Soares Magalhaes R, Paye J, Koroma J, Sonnie M, Clements A, et al. Combined spatial prediction of schistosomiasis and soil-transmitted helminthiasis in Sierra Leone: a tool for integrated disease control. PLoS Negl Trop Dis. 2012;6:e1694 pubmed publisher
    ..mansoni and soil-transmitted helminths, the national control programme was able to plan the MDA strategies according to the World Health Organization guidelines for preventive chemotherapy for these diseases...
  8. McSorley H, Hewitson J, Maizels R. Immunomodulation by helminth parasites: defining mechanisms and mediators. Int J Parasitol. 2013;43:301-10 pubmed publisher
  9. Chammartin F, Scholte R, Guimaraes L, Tanner M, Utzinger J, Vounatsou P. Soil-transmitted helminth infection in South America: a systematic review and geostatistical meta-analysis. Lancet Infect Dis. 2013;13:507-18 pubmed publisher
    ..Our findings offer important baseline support for spatial targeting of soil-transmitted helminthiasis control, and suggest that more information about the prevalence of soil-transmitted helminth infection is ..

More Information

Publications89

  1. Ndibazza J, Mpairwe H, Webb E, Mawa P, Nampijja M, Muhangi L, et al. Impact of anthelminthic treatment in pregnancy and childhood on immunisations, infections and eczema in childhood: a randomised controlled trial. PLoS ONE. 2012;7:e50325 pubmed publisher
    ..Given the low helminth prevalence in our children, the effect of albendazole on malaria is likely to be direct. Current Controlled Trials ISRCTN32849447. ..
  2. Tchuem Tchuenté L, Kamwa Ngassam R, Sumo L, Ngassam P, Dongmo Noumedem C, Nzu D, et al. Mapping of schistosomiasis and soil-transmitted helminthiasis in the regions of centre, East and West Cameroon. PLoS Negl Trop Dis. 2012;6:e1553 pubmed publisher
    Schistosomiasis and soil-transmitted helminthiasis (STH) are widely distributed in Cameroon...
  3. Bath J, Eneh P, Bakken A, Knox M, Schiedt M, Campbell J. The impact of perception and knowledge on the treatment and prevention of intestinal worms in the Manikganj district of Bangladesh. Yale J Biol Med. 2010;83:171-84 pubmed
  4. Ahmed A, Al Mekhlafi H, Al Adhroey A, Ithoi I, Abdulsalam A, Surin J. The nutritional impacts of soil-transmitted helminths infections among Orang Asli schoolchildren in rural Malaysia. Parasit Vectors. 2012;5:119 pubmed publisher
    ..Sustainable deworming programme at school and community levels among these populations will help to improve their health and nutritional status. ..
  5. Yap P, Du Z, Wu F, Jiang J, Chen R, Zhou X, et al. Rapid re-infection with soil-transmitted helminths after triple-dose albendazole treatment of school-aged children in Yunnan, People's Republic of China. Am J Trop Med Hyg. 2013;89:23-31 pubmed publisher
    ..Rapid re-infection with A. lumbricoides was observed: the prevalence 4 and 6 months post-treatment was 75.8% and 83.8%, respectively. Re-infection with hookworm and T. trichiura was considerably slower...
  6. Ilechukwu G, Ilechukwu C, Ozumba A, Ojinnaka N, Ibe B, Onwasigwe C. Some behavioural risk factors for intestinal helminthiasis in nursery and primary school children in Enugu, south eastern Nigeria. Niger J Clin Pract. 2010;13:288-93 pubmed
    The objective of this study was to determine some common behavioural risk factors for intestinal helminthiasis in nursery and primary school children in Enugu...
  7. Sangaré L, Herrin B, Herrin B, John Stewart G, Walson J. Species-specific treatment effects of helminth/HIV-1 co-infection: a systematic review and meta-analysis. Parasitology. 2011;138:1546-58 pubmed publisher
  8. Smout M, Kotze A, McCarthy J, Loukas A. A novel high throughput assay for anthelmintic drug screening and resistance diagnosis by real-time monitoring of parasite motility. PLoS Negl Trop Dis. 2010;4:e885 pubmed publisher
    ..The method is also amenable to use for other purposes where motility is assessed, such as gene silencing or antibody-mediated killing. ..
  9. Chu K, Watermeyer G, Shelly L, Janssen J, May T, Brink K, et al. Childhood helminth exposure is protective against inflammatory bowel disease: a case control study in South Africa. Inflamm Bowel Dis. 2013;19:614-20 pubmed publisher
    ..Our epidemiologic conclusions provide support that helminths may have immunomodulatory effects which provides protection against the development of IBD later in life. ..
  10. Albonico M, Ame S, Vercruysse J, Levecke B. Comparison of the Kato-Katz thick smear and McMaster egg counting techniques for monitoring drug efficacy against soil-transmitted helminths in schoolchildren on Pemba Island, Tanzania. Trans R Soc Trop Med Hyg. 2012;106:199-201 pubmed publisher
    ..The study revealed comparable drug efficacy results for both methods and confirmed the potency of the McMaster technique as an alternative method for monitoring large-scale deworming programmes...
  11. Jex A, Lim Y, Bethony J, Hotez P, Young N, Gasser R. Soil-transmitted helminths of humans in Southeast Asia--towards integrated control. Adv Parasitol. 2011;74:231-65 pubmed publisher
  12. Mpairwe H, Webb E, Muhangi L, Ndibazza J, Akishule D, Nampijja M, et al. Anthelminthic treatment during pregnancy is associated with increased risk of infantile eczema: randomised-controlled trial results. Pediatr Allergy Immunol. 2011;22:305-12 pubmed publisher
  13. Koroma J, Peterson J, Gbakima A, Nylander F, Sahr F, Soares Magalhaes R, et al. Geographical distribution of intestinal schistosomiasis and soil-transmitted helminthiasis and preventive chemotherapy strategies in Sierra Leone. PLoS Negl Trop Dis. 2010;4:e891 pubmed publisher
    A national baseline mapping of schistosomiasis and soil-transmitted helminthiasis (STH) was performed in Sierra Leone...
  14. Bourke C, Maizels R, Mutapi F. Acquired immune heterogeneity and its sources in human helminth infection. Parasitology. 2011;138:139-59 pubmed publisher
    ..This review summarizes key differences identified in human acquired immune responses to nematode and trematode infections of public health importance and explores the factors contributing to these variations. ..
  15. Traoré S, Odermatt P, Bonfoh B, Utzinger J, Aka N, Adoubryn K, et al. No Paragonimus in high-risk groups in Côte d'Ivoire, but considerable prevalence of helminths and intestinal protozoon infections. Parasit Vectors. 2011;4:96 pubmed publisher
    ..The disease is often confused with tuberculosis. Paragonimiasis is thought to be endemic in south-western Côte d'Ivoire...
  16. McCarthy J, Lustigman S, Yang G, Barakat R, García H, Sripa B, et al. A research agenda for helminth diseases of humans: diagnostics for control and elimination programmes. PLoS Negl Trop Dis. 2012;6:e1601 pubmed publisher
    ..In this review, the diagnostic technologies relevant to control of helminth infections, either available or in development, are reviewed. Critical gaps are identified and opportunities to improve needed technologies are discussed. ..
  17. Lustigman S, Prichard R, Gazzinelli A, Grant W, Boatin B, McCarthy J, et al. A research agenda for helminth diseases of humans: the problem of helminthiases. PLoS Negl Trop Dis. 2012;6:e1582 pubmed publisher
    ..The helminth infections that will be discussed include: onchocerciasis, lymphatic filariasis, soil-transmitted helminthiases, schistosomiasis, food-borne trematodiases, and taeniasis/cysticercosis. ..
  18. Bethony J, Cole R, Guo X, Kamhawi S, Lightowlers M, Loukas A, et al. Vaccines to combat the neglected tropical diseases. Immunol Rev. 2011;239:237-70 pubmed publisher
    ..Also highlighted are the contributions being made by non-profit product development partnerships that are working to overcome some of the economic challenges in vaccine manufacture, clinical testing, and global access. ..
  19. Webb E, Ekii A, Pala P. Epidemiology and immunology of helminth-HIV interactions. Curr Opin HIV AIDS. 2012;7:245-53 pubmed publisher
    ..In this review, we summarize recent immunological and epidemiological advances in the understanding of HIV-1-helminth co-infections...
  20. Jeandron A, Abdyldaieva G, Usubalieva J, Ensink J, Cox J, Matthys B, et al. Accuracy of the Kato-Katz, adhesive tape and FLOTAC techniques for helminth diagnosis among children in Kyrgyzstan. Acta Trop. 2010;116:185-92 pubmed publisher
    ..dendriticum. Overall results suggest that, although FLOTAC represents a promising technique for helminth diagnosis in Kyrgyzstan, the repeated adhesive tape test remains so far the method of choice for diagnosing E. vermicularis...
  21. Gunawardena K, Kumarendran B, Ebenezer R, Gunasingha M, Pathmeswaran A, de Silva N. Soil-transmitted helminth infections among plantation sector schoolchildren in Sri Lanka: prevalence after ten years of preventive chemotherapy. PLoS Negl Trop Dis. 2011;5:e1341 pubmed publisher
    ..Biannual mass de-worming targeting children aged 3-18 years started in 1994 and was continued until 2005. The present study was carried out to assess the status of infection four years after cessation of mass de-worming...
  22. Fürst T, Müller I, Coulibaly J, Yao A, Utzinger J, N Goran E. Questionnaire-based approach to assess schoolchildren's physical fitness and its potential role in exploring the putative impact of helminth and Plasmodium spp. infections in Côte d'Ivoire. Parasit Vectors. 2011;4:116 pubmed publisher
    ..The previous practice of eliciting DWs by expert opinion has been challenged. More recent approaches employed quality of life (QoL) questionnaires to establish patient-based DWs, but results are ambiguous...
  23. Tun A, Myat S, Gabrielli A, Montresor A. Control of soil-transmitted helminthiasis in Myanmar: results of 7 years of deworming. Trop Med Int Health. 2013;18:1017-20 pubmed publisher
    ..5% at baseline to less than 7%. The results are encouraging and a reduction of the frequency of deworming can be envisaged in two of four ecological areas of Myanmar. ..
  24. Magalhães R, Clements A, Patil A, Gething P, Brooker S. The applications of model-based geostatistics in helminth epidemiology and control. Adv Parasitol. 2011;74:267-96 pubmed publisher
    ..Focussing on schistosomiasis and soil-transmitted helminthiasis, with additional examples for lymphatic filariasis and onchocerciasis, we review the progress made to date ..
  25. Blackwell A, Snodgrass J, Madimenos F, Sugiyama L. Life history, immune function, and intestinal helminths: Trade-offs among immunoglobulin E, C-reactive protein, and growth in an Amazonian population. Am J Hum Biol. 2010;22:836-48 pubmed publisher
    ..Given limited energy budgets, these shifts may involve changes in energy allocation toward competing demands. Here we test for potential trade-offs between growth, IgE, and the inflammatory marker C-reactive protein (CRP)...
  26. Wang X, Zhang L, Luo R, Wang G, Chen Y, Medina A, et al. Soil-transmitted helminth infections and correlated risk factors in preschool and school-aged children in rural Southwest China. PLoS ONE. 2012;7:e45939 pubmed publisher
  27. Ahmed A, Al Mekhlafi H, Azam M, Ithoi I, Al Adhroey A, Abdulsalam A, et al. Soil-transmitted helminthiasis: a critical but neglected factor influencing school participation of Aboriginal children in rural Malaysia. Parasitology. 2012;139:802-8 pubmed publisher
    Soil-transmitted helminthiasis (STH), among the most common neglected tropical diseases, is a major public health problem in Malaysia with a possible impact on the nutritional status and school participation of rural children...
  28. Levecke B, Speybroeck N, Dobson R, Vercruysse J, Charlier J. Novel insights in the fecal egg count reduction test for monitoring drug efficacy against soil-transmitted helminths in large-scale treatment programs. PLoS Negl Trop Dis. 2011;5:e1427 pubmed publisher
  29. Walson J, Singa B, Sangaré L, Naulikha J, Piper B, Richardson B, et al. Empiric deworming to delay HIV disease progression in adults with HIV who are ineligible for initiation of antiretroviral treatment (the HEAT study): a multi-site, randomised trial. Lancet Infect Dis. 2012;12:925-32 pubmed publisher
    ..Alternative approaches are needed to delay HIV disease progression in areas where co-infections are common. ..
  30. Ivan E, Crowther N, Rucogoza A, Osuwat L, Munyazesa E, Mutimura E, et al. Malaria and helminthic co-infection among HIV-positive pregnant women: prevalence and effects of antiretroviral therapy. Acta Trop. 2012;124:179-84 pubmed publisher
    ..The differential effect of ARTs on the risk of helminth infection is of interest and should be examined prospectively in larger patient groups...
  31. Koyasu S, Moro K, Tanabe M, Takeuchi T. Natural helper cells: a new player in the innate immune response against helminth infection. Adv Immunol. 2010;108:21-44 pubmed publisher
    ..We discuss here the mechanisms of innate production of Th2 cytokines in host immune responses against helminth infection...
  32. Sousa Figueiredo J, Day M, Betson M, Rowell C, Wamboko A, Arinaitwe M, et al. Field survey for strongyloidiasis in eastern Uganda with observations on efficacy of preventive chemotherapy and co-occurrence of soil-transmitted helminthiasis/intestinal schistosomiasis. J Helminthol. 2011;85:325-33 pubmed publisher
    ..stercoralis, careful interpretation of the ELISA is warranted, especially where diagnosis is likely being confounded by polyparasitism and/or other treatment regimens; new molecular screening tools are clearly needed...
  33. Taylor Robinson D, Maayan N, Soares Weiser K, Donegan S, Garner P. Deworming drugs for soil-transmitted intestinal worms in children: effects on nutritional indicators, haemoglobin and school performance. Cochrane Database Syst Rev. 2012;:CD000371 pubmed publisher
    ..Given the important health and societal benefits attributed to this intervention, we sought to determine whether they are based on reliable evidence...
  34. Allen J, Maizels R. Diversity and dialogue in immunity to helminths. Nat Rev Immunol. 2011;11:375-88 pubmed publisher
    ..Finally, we more broadly consider how these immunological players are blended and regulated in order to accommodate persistent infection or to mount a vigorous protective response and achieve sterile immunity...
  35. Sohn W, Chai J, Yong T, Eom K, Yoon C, Sinuon M, et al. Echinostoma revolutum infection in children, Pursat Province, Cambodia. Emerg Infect Dis. 2011;17:117-9 pubmed publisher
    ..The prevalence of infection with echinostome flukes ranged from 7.5% to 22.4% in 4 schools surveyed. Adult worms were identified as Echinostoma revolutum...
  36. Prichard R, Basáñez M, Boatin B, McCarthy J, García H, Yang G, et al. A research agenda for helminth diseases of humans: intervention for control and elimination. PLoS Negl Trop Dis. 2012;6:e1549 pubmed publisher
  37. Olliaro P, Seiler J, Kuesel A, Horton J, Clark J, Don R, et al. Potential drug development candidates for human soil-transmitted helminthiases. PLoS Negl Trop Dis. 2011;5:e1138 pubmed publisher
    Few drugs are available for soil-transmitted helminthiasis (STH); the benzimidazoles albendazole and mebendazole are the only drugs being used for preventive chemotherapy as they can be given in one single dose with no weight adjustment...
  38. Levecke B, Behnke J, Ajjampur S, Albonico M, Ame S, Charlier J, et al. A comparison of the sensitivity and fecal egg counts of the McMaster egg counting and Kato-Katz thick smear methods for soil-transmitted helminths. PLoS Negl Trop Dis. 2011;5:e1201 pubmed publisher
    ..A promising alternative is the McMaster egg counting method (McMaster), commonly used in veterinary parasitology, but rarely so for the detection of STH in human stool...
  39. Yap P, Du Z, Chen R, Zhang L, Wu F, Wang J, et al. Soil-transmitted helminth infections and physical fitness in school-aged Bulang children in southwest China: results from a cross-sectional survey. Parasit Vectors. 2012;5:50 pubmed publisher
    ..R. China). Standardized, quality-controlled methods were employed to determine STH infections (Kato-Katz technique), haemoglobin levels, anthropometry (body weight and height) and physical fitness (20-m shuttle run test)...
  40. Maizels R, Hewitson J, Smith K. Susceptibility and immunity to helminth parasites. Curr Opin Immunol. 2012;24:459-66 pubmed publisher
  41. Correale J, Farez M. The impact of parasite infections on the course of multiple sclerosis. J Neuroimmunol. 2011;233:6-11 pubmed publisher
    ..These new observations on parasite infections associated to MS indicate that parasite regulation of host immunity can alter the course of MS...
  42. Maizels R, McSorley H, Smyth D. Helminths in the hygiene hypothesis: sooner or later?. Clin Exp Immunol. 2014;177:38-46 pubmed publisher
    ..is the influence of parasites on immunity one that acts primarily in early life, and at initiation of the immune response, or in adulthood and when recall responses occur? In short, parasite immunosuppression - sooner or later? ..
  43. Otranto D, Eberhard M. Zoonotic helminths affecting the human eye. Parasit Vectors. 2011;4:41 pubmed publisher
    ..The biology and epidemiology of the most frequently reported HIE are discussed as well as clinical description of the diseases, diagnostic considerations and video clips on their presentation and surgical treatment...
  44. Ahmed A, Al Mekhlafi H, Choy S, Ithoi I, Al Adhroey A, Abdulsalam A, et al. The burden of moderate-to-heavy soil-transmitted helminth infections among rural malaysian aborigines: an urgent need for an integrated control programme. Parasit Vectors. 2011;4:242 pubmed publisher
    ..Soil-transmitted helminth (STH) infections, among the most common neglected tropical diseases, continue to be a major threat to the health and socioeconomic wellbeing of infected people especially children in developing countries...
  45. Zhang Y, Macarthur C, Mubila L, Baker S. Control of neglected tropical diseases needs a long-term commitment. BMC Med. 2010;8:67 pubmed publisher
    ..neglected tropical diseases (lymphatic filariasis, onchocerciasis, schistosomiasis, soil-transmitted helminthiasis and trachoma), using a package of integrated drug delivery according to the World Health Organization ..
  46. Starr M, Montgomery S. Soil-transmitted Helminthiasis in the United States: a systematic review--1940-2010. Am J Trop Med Hyg. 2011;85:680-4 pubmed publisher
    ..Because the status of disease remains unclear, there is a need for additional studies to determine if soil-transmitted helminths remain endemic in the United States...
  47. Colston J, Saboyá M. Soil-transmitted helminthiasis in Latin America and the Caribbean: modelling the determinants, prevalence, population at risk and costs of control at sub-national level. Geospat Health. 2013;7:321-40 pubmed
    ..A study of this scope is prone to many limitations which restrict the interpretation of the results and the uses to which its findings may be put. We discuss several of these limitations...
  48. Habtamu K, Degarege A, Ye Ebiyo Y, Erko B. Comparison of the Kato-Katz and FLOTAC techniques for the diagnosis of soil-transmitted helminth infections. Parasitol Int. 2011;60:398-402 pubmed publisher
    ..Further standardization and validation are still required in different epidemiological settings with varying levels of intensity of infections before recommending FLOTAC for large-scale community diagnosis...
  49. Sanchez A, Gabrie J, Usuanlele M, Rueda M, Canales M, Gyorkos T. Soil-transmitted helminth infections and nutritional status in school-age children from rural communities in Honduras. PLoS Negl Trop Dis. 2013;7:e2378 pubmed publisher
    ..However, current evidence is lacking in regards to their prevalence, intensity and their impact on children's health...
  50. McSorley H, Maizels R. Helminth infections and host immune regulation. Clin Microbiol Rev. 2012;25:585-608 pubmed publisher
    ..Understanding and exploiting the interactions between these parasites and the host regulatory network are therefore likely to highlight new strategies to control both infectious and immunological diseases...
  51. Fürst T, Silué K, Ouattara M, N Goran D, Adiossan L, N Guessan Y, et al. Schistosomiasis, soil-transmitted helminthiasis, and sociodemographic factors influence quality of life of adults in Côte d'Ivoire. PLoS Negl Trop Dis. 2012;6:e1855 pubmed publisher
    ..However, disability weights, which capture the disability incurred by a typical patient of a certain condition, are fundamental to such burden calculation and their determination remains a widely debated issue...
  52. Gause W, Wynn T, Allen J. Type 2 immunity and wound healing: evolutionary refinement of adaptive immunity by helminths. Nat Rev Immunol. 2013;13:607-14 pubmed publisher
  53. Harris N, Gause W. To B or not to B: B cells and the Th2-type immune response to helminths. Trends Immunol. 2011;32:80-8 pubmed publisher
    ..In this review, we examine the role of B cells during Th2-type immune response to these multicellular parasites...
  54. Magalhães R, Clements A. Mapping the risk of anaemia in preschool-age children: the contribution of malnutrition, malaria, and helminth infections in West Africa. PLoS Med. 2011;8:e1000438 pubmed publisher
  55. Acka C, Raso G, N Goran E, Tschannen A, Bogoch I, Séraphin E, et al. Parasitic worms: knowledge, attitudes, and practices in Western Côte d'Ivoire with implications for integrated control. PLoS Negl Trop Dis. 2010;4:e910 pubmed publisher
    ..However, local knowledge, attitudes, and practices (KAP) of parasitic worms are poorly understood, although such information is required for prevention and sustainable control...
  56. Voehringer D. Basophils in immune responses against helminths. Microbes Infect. 2011;13:881-7 pubmed publisher
    ..Based on recent reports, this review discusses potential roles of basophils and other cells during early and late phases of the immune response against parasitic worms...
  57. Djuardi Y, Wammes L, Supali T, Sartono E, Yazdanbakhsh M. Immunological footprint: the development of a child's immune system in environments rich in microorganisms and parasites. Parasitology. 2011;138:1508-18 pubmed publisher
  58. Abruzzi A, Fried B. Coinfection of Schistosoma (Trematoda) with bacteria, protozoa and helminths. Adv Parasitol. 2011;77:1-85 pubmed publisher
    ..Hopefully, future studies will elucidate valuable new information on the interesting subject of coinfection of Schistosoma with other organisms...
  59. Taylor M, Van Der Werf N, Maizels R. T cells in helminth infection: the regulators and the regulated. Trends Immunol. 2012;33:181-9 pubmed publisher
    ..Future vaccine or therapeutic strategies should aim to minimize extrinsic regulatory effects and simultaneously negate Th2 anergy to drive effector responses into a long-term functionally competent state...
  60. Basanez M, McCarthy J, French M, Yang G, Walker M, Gambhir M, et al. A research agenda for helminth diseases of humans: modelling for control and elimination. PLoS Negl Trop Dis. 2012;6:e1548 pubmed publisher
    ..A research and development agenda for helminthiasis modelling is proposed based on identified gaps that need to be addressed for models to become useful decision ..
  61. Hamid F, Wiria A, Wammes L, Kaisar M, Lell B, Ariawan I, et al. A longitudinal study of allergy and intestinal helminth infections in semi urban and rural areas of Flores, Indonesia (ImmunoSPIN Study). BMC Infect Dis. 2011;11:83 pubmed publisher
    ..The question of whether helminth infections play a role in allergic diseases can best be addressed by intervention studies. None of the studies so far have been based on a large scale placebo-controlled trial...
  62. Nasr N, Al Mekhlafi H, Ahmed A, Roslan M, Bulgiba A. Towards an effective control programme of soil-transmitted helminth infections among Orang Asli in rural Malaysia. Part 2: Knowledge, attitude, and practices. Parasit Vectors. 2013;6:28 pubmed publisher
    ..Part 2 of this study aims to evaluate the knowledge, attitude and practices (KAP) on STH infections among Orang Asli in Peninsular Malaysia...
  63. Leslie J, Garba A, Oliva E, Barkire A, Tinni A, Djibo A, et al. Schistosomiasis and soil-transmitted helminth control in Niger: cost effectiveness of school based and community distributed mass drug administration [corrected]. PLoS Negl Trop Dis. 2011;5:e1326 pubmed publisher
    ..In two years 4.3 million treatments were delivered in 40 districts using school based and community distribution...
  64. Daniłowicz Luebert E, O Regan N, Steinfelder S, Hartmann S. Modulation of specific and allergy-related immune responses by helminths. J Biomed Biotechnol. 2011;2011:821578 pubmed publisher
    ..We also examine recent findings on helminth-derived molecules that can be used as tools to pinpoint the underlying mechanisms of immune regulation or to determine new anti-inflammatory therapeutics...
  65. Machicado J, Marcos L, Tello R, Canales M, Terashima A, Gotuzzo E. Diagnosis of soil-transmitted helminthiasis in an Amazonic community of Peru using multiple diagnostic techniques. Trans R Soc Trop Med Hyg. 2012;106:333-9 pubmed publisher
    ..intestinalis, H. nana, S. stercoralis and hookworm. In conclusion, the SSTT is not inferior to Kato-Katz for the diagnosis of common STH infections but is largely superior for detecting intestinal protozoa and S. stercoralis larvae...
  66. Coulibaly J, Fürst T, Silué K, Knopp S, Hauri D, Ouattara M, et al. Intestinal parasitic infections in schoolchildren in different settings of Côte d'Ivoire: effect of diagnostic approach and implications for control. Parasit Vectors. 2012;5:135 pubmed publisher
  67. Namwanje H, Kabatereine N, Olsen A. The acceptability and safety of praziquantel alone and in combination with mebendazole in the treatment of Schistosoma mansoni and soil-transmitted helminthiasis in children aged 1-4 years in Uganda. Parasitology. 2011;138:1586-92 pubmed publisher
    ..been extensively used together with praziquantel against infections with schistosomiasis and soil-transmitted helminthiasis (STH) in school-aged children, no specific acceptability or safety studies have been published on this drug ..
  68. Wiria A, Djuardi Y, Supali T, Sartono E, Yazdanbakhsh M. Helminth infection in populations undergoing epidemiological transition: a friend or foe?. Semin Immunopathol. 2012;34:889-901 pubmed publisher
    ..Furthermore, we address the issue of decreasing helminth infections in many parts of the world within the context of increasing inflammatory, metabolic, and cardiovascular diseases...
  69. Amare B, Ali J, Moges B, Yismaw G, Belyhun Y, Gebretsadik S, et al. Nutritional status, intestinal parasite infection and allergy among school children in northwest Ethiopia. BMC Pediatr. 2013;13:7 pubmed publisher
    ..The present study was therefore designed to evaluate the relationship between nutritional status, parasite infection and prevalence of allergy among school children...
  70. Steinmann P, Utzinger J, Du Z, Jiang J, Chen J, Hattendorf J, et al. Efficacy of single-dose and triple-dose albendazole and mebendazole against soil-transmitted helminths and Taenia spp.: a randomized controlled trial. PLoS ONE. 2011;6:e25003 pubmed publisher
    ..We compared the efficacy of single-dose versus triple-dose treatment against hookworm and other STHs in a community-based randomized controlled trial in the People's Republic of China...
  71. Hodges M, Koroma M, Baldé M, Turay H, Fofanah I, Divall M, et al. Current status of schistosomiasis and soil-transmitted helminthiasis in Beyla and Macenta Prefectures, Forest Guinea. Trans R Soc Trop Med Hyg. 2011;105:672-4 pubmed publisher
    ..The prevalence of schistosomiasis was similar to those reported in the 1990s in the region; however, the prevalence of soil-transmitted helminths has since fallen. These findings illustrate the need for schistosomiasis control in Guinea...
  72. Pinheiro I, de Castro M, Mitterofhe A, Pires F, Abramo C, Ribeiro L, et al. Prevalence and risk factors for giardiasis and soil-transmitted helminthiasis in three municipalities of Southeastern Minas Gerais State, Brazil: risk factors for giardiasis and soil-transmitted helminthiasis. Parasitol Res. 2011;108:1123-30 pubmed publisher
    Giardiasis and soil-transmitted helminthiasis (STH) are parasitic diseases that are among the major health concerns observed in economically disadvantaged populations of developing countries, and have clear social and environmental bases...
  73. Boel M, Carrara V, Rijken M, Proux S, Nacher M, Pimanpanarak M, et al. Complex Interactions between soil-transmitted helminths and malaria in pregnant women on the Thai-Burmese border. PLoS Negl Trop Dis. 2010;4:e887 pubmed publisher
    ..We examined the association between geohelminths and malaria in pregnancy on the Thai-Burmese border...
  74. Osei A, Houser R, Bulusu S, Joshi T, Hamer D. Nutritional status of primary schoolchildren in Garhwali Himalayan villages of India. Food Nutr Bull. 2010;31:221-33 pubmed
    ..However, past studies have narrowly focused on only a few micronutrients and have not carefully evaluated the association between sociodemographic factors and nutritional status of schoolchildren...
  75. Neill D, McKenzie A. Nuocytes and beyond: new insights into helminth expulsion. Trends Parasitol. 2011;27:214-21 pubmed publisher
    ..It also affords us the opportunity to highlight the diversity of immune responses that can be driven by innate cells responding rapidly to early cytokine cues...
  76. Kabatereine N, Standley C, Sousa Figueiredo J, Fleming F, Stothard J, Talisuna A, et al. Integrated prevalence mapping of schistosomiasis, soil-transmitted helminthiasis and malaria in lakeside and island communities in Lake Victoria, Uganda. Parasit Vectors. 2011;4:232 pubmed publisher
    ..In this study, nine lakeshore and island districts were surveyed for the prevalence of NTDs and malaria, as well as educational and health infrastructure...
  77. Adegnika A, Kremsner P. Epidemiology of malaria and helminth interaction: a review from 2001 to 2011. Curr Opin HIV AIDS. 2012;7:221-4 pubmed publisher
    Malaria and helminthiasis are endemic in the same geographic areas, and may coinfect the same host. In the literature there is some controversy about the effect of helminth infection on malaria.
  78. Njenga S, Mwandawiro C, Muniu E, Mwanje M, Haji F, Bockarie M. Adult population as potential reservoir of NTD infections in rural villages of Kwale district, Coastal Kenya: implications for preventive chemotherapy interventions policy. Parasit Vectors. 2011;4:175 pubmed publisher
    ..villages to provide information on the status of NTDs, including urinary schistosomiasis, soil-transmitted helminthiasis (STH), and lymphatic filariasis...
  79. Montresor A. Cure rate is not a valid indicator for assessing drug efficacy and impact of preventive chemotherapy interventions against schistosomiasis and soil-transmitted helminthiasis. Trans R Soc Trop Med Hyg. 2011;105:361-3 pubmed publisher
    ..context of preventive chemotherapy programmes for morbidity control of schistosomiasis and soil-transmitted helminthiasis. The capacity to evaluate accurately the efficacy of the drugs used as well as the health impact produced by ..
  80. Vercruysse J, Levecke B, Prichard R. Human soil-transmitted helminths: implications of mass drug administration. Curr Opin Infect Dis. 2012;25:703-8 pubmed publisher
    ..In this review, we discuss the practical implications of MDA programs on the development of anthelmintic resistance in human soil-transmitted helminths (STH)...