parasitic diseases

Summary

Summary: Infections or infestations with PARASITES. They are often contracted through contact with an intermediate vector, but may occur as the result of direct exposure.

Top Publications

  1. Modjarrad K, Vermund S. Effect of treating co-infections on HIV-1 viral load: a systematic review. Lancet Infect Dis. 2010;10:455-63 pubmed publisher
    ..0 log(10) copies per mL or less, even small changes in plasma HIV-RNA concentrations have been shown to slow HIV progression and could translate into population-level benefits in lowering HIV transmission risk...
  2. Bockarie M, Kelly Hope L, Rebollo M, Molyneux D. Preventive chemotherapy as a strategy for elimination of neglected tropical parasitic diseases: endgame challenges. Philos Trans R Soc Lond B Biol Sci. 2013;368:20120144 pubmed publisher
    ..We discuss the challenges of managing complex partnerships, and maintain advocacy messages for the continued support for elimination of these preventable diseases. ..
  3. Hanel S, Velavan T, Kremsner P, Kun J. Novel and functional regulatory SNPs in the promoter region of FOXP3 gene in a Gabonese population. Immunogenetics. 2011;63:409-15 pubmed publisher
    ..The identification of SNPs that modify function in the promoter regions could provide a basis for studying parasite susceptibility in association studies...
  4. Cavalli A, Bamba S, Traore M, Boelaert M, Coulibaly Y, Polman K, et al. Interactions between Global Health Initiatives and country health systems: the case of a neglected tropical diseases control program in Mali. PLoS Negl Trop Dis. 2010;4:e798 pubmed publisher
  5. Hotez P. Enlarging the "Audacious Goal": elimination of the world's high prevalence neglected tropical diseases. Vaccine. 2011;29 Suppl 4:D104-10 pubmed publisher
    ..S. Government and selected European governments, however, the emerging market economies, such as Brazil, China, India, Mexico, and Nigeria, and wealthy countries in the Middle East will also have to substantially contribute...
  6. Torgerson P, de Silva N, Fèvre E, Kasuga F, Rokni M, Zhou X, et al. The global burden of foodborne parasitic diseases: an update. Trends Parasitol. 2014;30:20-6 pubmed publisher
    ..This review gives an update of the progress on evaluating the burden of foodborne parasitic diseases that has been generated by this study...
  7. Keiser J, Ingram K, Utzinger J. Antiparasitic drugs for paediatrics: systematic review, formulations, pharmacokinetics, safety, efficacy and implications for control. Parasitology. 2011;138:1620-32 pubmed publisher
    ..drugs for children are of pivotal importance given the large proportion of burden attributable to parasitic diseases in this age group, and growing efforts to administer, as widely as possible, antiparasitic drugs to at-risk ..
  8. Li X, Zhou X. Co-infection of tuberculosis and parasitic diseases in humans: a systematic review. Parasit Vectors. 2013;6:79 pubmed publisher
    Co-infection of tuberculosis and parasitic diseases in humans is an important public problem in co-endemic areas in developing countries. However, there is a paucity of studies on co-infection and even fewer reviews...
  9. Velavan T, Bechlars S, Tomiuk J, Kremsner P, Kun J. Molecular characterization of regulatory polymorphisms in the promoter region of the STAT6 gene in a Gabonese population. Mem Inst Oswaldo Cruz. 2011;106:65-9 pubmed
    ..One promoter variant, rs3024944 (G/C), revealed an altered expression of the marker gene. The identification of function-altering SNPs in the promoter may facilitate studying parasite susceptibility in association studies...

More Information

Publications72

  1. Currie T, Mace R. Analyses do not support the parasite-stress theory of human sociality. Behav Brain Sci. 2012;35:83-5 pubmed publisher
    ..Furthermore, even if associations between these variables do exist, the analyses presented here do not provide evidence for Fincher & Thornhill's (F&T's) proposed causal mechanism...
  2. Hotez P. Neglected tropical disease control in the "post-American world". PLoS Negl Trop Dis. 2010;4: pubmed publisher
  3. Lal C, Huggins J, Sahn S. Parasitic diseases of the pleura. Am J Med Sci. 2013;345:385-9 pubmed publisher
    ..This article provides a comprehensive review of parasitic infections involving the pleura. A high index of suspicion in the appropriate clinical setting is required to facilitate prompt diagnosis and treatment of these diseases...
  4. Allen T, Parker M. The "other diseases" of the Millennium Development Goals: rhetoric and reality of free drug distribution to cure the poor's parasites. Third World Q. 2011;32:91-117 pubmed
    ..If current trends are not corrected, declining rates of NTD infection will not be sustained. Much more rigorous and effective monitoring is essential...
  5. Fincher C, Thornhill R. Parasite-stress promotes in-group assortative sociality: the cases of strong family ties and heightened religiosity. Behav Brain Sci. 2012;35:61-79 pubmed publisher
    ..The findings support the parasite-stress theory of sociality, that is, the proposal that parasite-stress is central to the evolution of social life in humans and other animals...
  6. Bethony J, Cole R, Guo X, Kamhawi S, Lightowlers M, Loukas A, et al. Vaccines to combat the neglected tropical diseases. Immunol Rev. 2011;239:237-70 pubmed publisher
    ..Also highlighted are the contributions being made by non-profit product development partnerships that are working to overcome some of the economic challenges in vaccine manufacture, clinical testing, and global access. ..
  7. Hotez P, Savioli L, Fenwick A. Neglected tropical diseases of the Middle East and North Africa: review of their prevalence, distribution, and opportunities for control. PLoS Negl Trop Dis. 2012;6:e1475 pubmed publisher
  8. Beaumier C, Gillespie P, Hotez P, Bottazzi M. New vaccines for neglected parasitic diseases and dengue. Transl Res. 2013;162:144-55 pubmed publisher
    ..These products will be some of the first with specific objectives to aid the world's poorest populations...
  9. Confalonieri U, Margonari C, Quintão A. Environmental change and the dynamics of parasitic diseases in the Amazon. Acta Trop. 2014;129:33-41 pubmed publisher
    ..Current land use practices which are changing the, epidemiological profile of the parasitic diseases in the region are road building; logging; mining; expansion of agriculture and cattle ranching and the ..
  10. Hotez P, Pecoul B. "Manifesto" for advancing the control and elimination of neglected tropical diseases. PLoS Negl Trop Dis. 2010;4:e718 pubmed publisher
  11. Maino A, Rossio R, Cugno M, Marzano A, Tedeschi A. Hypereosinophilic syndrome, Churg-Strauss syndrome and parasitic diseases: possible links between eosinophilia and thrombosis. Curr Vasc Pharmacol. 2012;10:670-5 pubmed
    ..One hundred and seventy- seven articles dealing with parasitic diseases and thrombosis were found, but only 15 manuscripts reporting thrombosis of unknown origin in 22 patients ..
  12. Zhou X, Wayling S, Bergquist R. Concepts in research capabilities strengthening positive experiences of network approaches by TDR in the People's Republic of China and Eastern Asia. Adv Parasitol. 2010;73:1-19 pubmed publisher
    ..Some Asian examples of how this can be accomplished are provided...
  13. Hotez P, Ehrenberg J. Escalating the global fight against neglected tropical diseases through interventions in the Asia Pacific region. Adv Parasitol. 2010;72:31-53 pubmed publisher
    ..Through a global network for NTDs, an innovative finance mechanism Is being created to control the most common neglected diseases across Asia...
  14. Velavan T, Bechlars S, Huang X, Kremsner P, Kun J. Novel regulatory SNPs in the promoter region of the TNFRSF18 gene in a Gabonese population. Braz J Med Biol Res. 2011;44:418-20 pubmed publisher
    ..18 (TNFRSF18) gene by direct sequencing in a group of male Gabonese individuals exposed to a wide array of parasitic diseases such as malaria, filariasis and schistosomiasis. Two new promoter variants were identified in 40 individuals...
  15. Sampasa Kanyinga H, Lévesque B, Anassour Laouan Sidi E, Côté S, Serhir B, Ward B, et al. Zoonotic infections in native communities of James Bay, Canada. Vector Borne Zoonotic Dis. 2012;12:473-81 pubmed publisher
    ..A review of the medical records revealed few clinical events potentially related to zoonotic exposures. However, public health authorities and health care workers in these communities should be alert to the risk of these zoonoses...
  16. Schaller M, Murray D. Mechanisms by which parasites influence cultures, and why they matter. Behav Brain Sci. 2012;35:91-2 pubmed publisher
    ..Rigorous research on specific mediating mechanisms is required to more completely articulate implications of parasite stress on human psychology and human culture...
  17. Manzano Román R, Siles Lucas M. MicroRNAs in parasitic diseases: potential for diagnosis and targeting. Mol Biochem Parasitol. 2012;186:81-6 pubmed publisher
    ..Additionally, the studies about parasitic manipulation of the host immune responses thought miRNAs could broaden our knowledge about basic aspects of the host-parasite relationships...
  18. Range N, Magnussen P, Mugomela A, Malenganisho W, Changalucha J, Temu M, et al. HIV and parasitic co-infections in tuberculosis patients: a cross-sectional study in Mwanza, Tanzania. Ann Trop Med Parasitol. 2007;101:343-51 pubmed
    ..The PTB patients in the study area were, however, still frequently co-infected with HIV and with parasitic infections that may increase morbidity and accelerate the progression of HIV disease. ..
  19. Thornhill R, Fincher C, Aran D. Parasites, democratization, and the liberalization of values across contemporary countries. Biol Rev Camb Philos Soc. 2009;84:113-31 pubmed publisher
    ..Finally, we hypothesize that past selection in the context of morbidity and mortality resulting from parasitic disease crafted many of the aspects of social psychology unique to humans. ..
  20. Gandon S, Day T. The evolutionary epidemiology of vaccination. J R Soc Interface. 2007;4:803-17 pubmed
    ..In particular, we argue that more work should be done evaluating the nature and magnitude of parasite fitness costs associated with adaptation to vaccinated hosts. ..
  21. Fenwick A. Waterborne infectious diseases--could they be consigned to history?. Science. 2006;313:1077-81 pubmed
    ..Donations of safe and effective drugs by several pharmaceutical companies, funds for delivering these donated drugs from foundations and bilateral donors, and effective global health partnerships should make these diseases history...
  22. Li T, He S, Zhao H, Zhao G, Zhu X. Major trends in human parasitic diseases in China. Trends Parasitol. 2010;26:264-70 pubmed publisher
    Tremendous progress has been made in the control and prevention of human parasitic diseases in mainland China in the past 30 years because of China's Reform and Opening to the Outside Policies initiated in 1978...
  23. André J, Gandon S. Vaccination, within-host dynamics, and virulence evolution. Evolution. 2006;60:13-23 pubmed
    ..We discuss the consequences of various vaccination strategies under different epidemiological situations using several distinct measures to evaluate the cost induced by the parasite on individuals and entire host populations. ..
  24. Fenton A, Perkins S. Applying predator-prey theory to modelling immune-mediated, within-host interspecific parasite interactions. Parasitology. 2010;137:1027-38 pubmed publisher
    ..We urge for more detailed empirical information relating immune activity to parasite load to enable better predictions of the dynamic consequences of immune-mediated interspecific interactions within parasite communities. ..
  25. Lim J. Parasitic diseases in the abdomen: imaging findings. Abdom Imaging. 2008;33:130-2 pubmed
    b>Parasitic diseases of the liver and biliary tract include echinococcosis, schistosomiasis, toxocariasis, clonorchiasis, and opisthorchiasis, affecting millions people in some endemic areas...
  26. Chen S, Liu Q, Zhang Y, Chen J, Li H, Chen Y, et al. Multi-host model-based identification of Armillifer agkistrodontis (Pentastomida), a new zoonotic parasite from China. PLoS Negl Trop Dis. 2010;4:e647 pubmed publisher
    ..However, their systematic position is not uncontested and historically, they have been considered as a separate phylum...
  27. Holt D, McCarthy J, Carapetis J. Parasitic diseases of remote Indigenous communities in Australia. Int J Parasitol. 2010;40:1119-26 pubmed publisher
    ..A number of parasitic diseases which are uncommon in the rest of the Australian population contribute to the high burden of disease in many ..
  28. Hotez P. Peace through vaccine diplomacy. Science. 2010;327:1301 pubmed publisher
  29. Brooker S, Utzinger J. Integrated disease mapping in a polyparasitic world. Geospat Health. 2007;1:141-6 pubmed
  30. McKerrow J, Caffrey C, Kelly B, Loke P, Sajid M. Proteases in parasitic diseases. Annu Rev Pathol. 2006;1:497-536 pubmed
    b>Parasitic diseases represent major global health problems of immense proportion...
  31. Sarner L, Fakoya A, Tawana C, Allen E, Copas A, Chiodini P, et al. The utility of screening for parasitic infections in HIV-1-infected Africans with eosinophilia in London. Int J STD AIDS. 2007;18:626-9 pubmed
    ..Individuals with eosinophilia should thus be screened for parasitic infections according to the infections prevalent in the countries they have lived in or visited for substantial periods of time...
  32. Freedman D, Weld L, Kozarsky P, Fisk T, Robins R, von Sonnenburg F, et al. Spectrum of disease and relation to place of exposure among ill returned travelers. N Engl J Med. 2006;354:119-30 pubmed
    ..Approximately 8 percent of travelers to the developing world require medical care during or after travel. Current understanding of morbidity profiles among ill returned travelers is based on limited data from the 1980s...
  33. . [A national survey on current status of the important parasitic diseases in human population]. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 2005;23:332-40 pubmed
    In order to understand the current status and trends of the important parasitic diseases in human population, to evaluate the effect of control activities in the past decade and provide scientific base for further developing control ..
  34. Hakim S, Gan C, Malkit K, Azian M, Chong C, Shaari N, et al. Parasitic infections among Orang Asli (aborigine) in the Cameron Highlands, Malaysia. Southeast Asian J Trop Med Public Health. 2007;38:415-9 pubmed
    ..However, heavy pre-existing parasitic infections could have contributed to the severity of the rotavirus diarrheal outbreak...
  35. Choi W, Chu J, Jiang M, Lee Y, Kim B, Kim D, et al. Analysis of parasitic diseases diagnosed by tissue biopsy specimens at KyungHee Medical Center (1984-2005) in Seoul, Korea. Korean J Parasitol. 2010;48:85-8 pubmed publisher
    We analyzed parasitic diseases diagnosed by tissue biopsy specimens at KyungHee Medical Center (KMC) from 1984 to 2005. The total number of parasite infection cases was 150 (0...
  36. Rumunu J, Brooker S, Hopkins A, Chane F, Emerson P, Kolaczinski J. Southern Sudan: an opportunity for NTD control and elimination?. Trends Parasitol. 2009;25:301-7 pubmed publisher
    ..This article describes the current status of NTDs and their control in Southern Sudan and outlines the opportunities for the development of evidence-based, innovative implementation of NTD control...
  37. Renslo A, McKerrow J. Drug discovery and development for neglected parasitic diseases. Nat Chem Biol. 2006;2:701-10 pubmed
    ..These neglected diseases present unique challenges to drug development that are being addressed by new consortia of scientists from academia and industry...
  38. Dakubo J, Etwire V, Kumoji R, Naaeder S. Human pentastomiasis: a case report. West Afr J Med. 2006;25:166-8 pubmed
    ..These parasites were diagnosed as Armillifer armillatus larvae. The patient made an uneventful recovery after the operation and was discharged. He is being followed up...
  39. Barnett E, Walker P. Role of immigrants and migrants in emerging infectious diseases. Med Clin North Am. 2008;92:1447-58, xi-xii pubmed publisher
    ..The emphasis of the article is on immigrant and migrant populations entering North America; the role of travelers in emerging infectious diseases is addressed in another article in this issue...
  40. Lillie P, Bazaz R, Greig J. Screening African HIV positive patients for imported parasitic infections. J Infect. 2008;57:481-4 pubmed publisher
    ..To assess the results of screening for tropical parasitic infections in HIV patients from Africa, presenting to an infectious diseases unit in the UK...
  41. Bates I, McKew S, Sarkinfada F. Anaemia: a useful indicator of neglected disease burden and control. PLoS Med. 2007;4:e231 pubmed
  42. Lim J, Kim S, Park C. Parasitic diseases of the biliary tract. AJR Am J Roentgenol. 2007;188:1596-603 pubmed
    ..The purpose of this article is to illustrate typical imaging findings of liver fluke infection and biliary ascariasis...
  43. Pullan R, Brooker S. The health impact of polyparasitism in humans: are we under-estimating the burden of parasitic diseases?. Parasitology. 2008;135:783-94 pubmed publisher
    ..Current methods of estimating the potential global morbidity due to parasitic diseases underestimate the health impact of polyparasitism, and possible reasons for this are presented...
  44. Lawn S, Wilkinson R. Immune reconstitution disease associated with parasitic infections following antiretroviral treatment. Parasite Immunol. 2006;28:625-33 pubmed
    ..Here we review the clinical spectrum and pathogenesis of IRD associated with parasitic infections...
  45. Yao M, Wu F, Tang L. Human pentastomiasis in China: case report and literature review. J Parasitol. 2008;94:1295-8 pubmed publisher
    ..nov infection. Pentastomiasis should be considered in differential diagnosis of patients with a history of abdominal symptoms and eating of poorly-cooked snakes...
  46. Naik A, Bhat S, Kholkute S. Hospitalisation due to infectious and parasitic diseases in District Civil Hospital, Belgaum, Karnataka. Indian J Public Health. 2008;52:161-3 pubmed
    To assess the burden of infectious and parasitic diseases on hospital services at District Civil Hospital (DCH) Belgaum, a retrospective study was carried out using discharge records concerning 8506 inpatients due to infectious and ..
  47. Tappe D, Büttner D. Diagnosis of human visceral pentastomiasis. PLoS Negl Trop Dis. 2009;3:e320 pubmed publisher
    ..This laboratory symposium focuses on the diagnosis of this unusual parasitic disease and presents its risk factors and epidemiology...
  48. Assefa S, Erko B, Medhin G, Assefa Z, Shimelis T. Intestinal parasitic infections in relation to HIV/AIDS status, diarrhea and CD4 T-cell count. BMC Infect Dis. 2009;9:155 pubmed publisher
    ..Hence, this study was undertaken to determine the prevalence of intestinal parasitic infection among people with and without HIV infection and its association with diarrhea and CD4 T-cell count...
  49. Molyneux D. Control of human parasitic diseases: Context and overview. Adv Parasitol. 2006;61:1-45 pubmed
    The control of parasitic diseases of humans has been undertaken since the aetiology and natural history of the infections was recognized and the deleterious effects on human health and well-being appreciated by policy makers, medical ..
  50. Salb A, Barkema H, Elkin B, Thompson R, Whiteside D, Black S, et al. Dogs as sources and sentinels of parasites in humans and wildlife, northern Canada. Emerg Infect Dis. 2008;14:60-3 pubmed publisher
    ..Dogs in remote settlements receive minimal veterinary care and may serve as sources and sentinels for parasites in persons and wildlife, and as parasite bridges between wildlife and humans...
  51. Kasai T, Nakatani H, Takeuchi T, Crump A. Research and control of parasitic diseases in Japan: current position and future perspectives. Trends Parasitol. 2007;23:230-5 pubmed
    Between 1950 and 1980, Japan eliminated several major parasitic diseases. In 1998, the Japanese Hashimoto Initiative was the first global programme to target parasitic diseases...
  52. Belkaid Y, Blank R, Suffia I. Natural regulatory T cells and parasites: a common quest for host homeostasis. Immunol Rev. 2006;212:287-300 pubmed
    ..We discuss the hypothesis that parasites have evolved means to manipulate the host's natural Treg population, thereby generating conditions that secure survival in their vertebrate host for an extended period of time...
  53. Date A, Joshi M, Patravale V. Parasitic diseases: Liposomes and polymeric nanoparticles versus lipid nanoparticles. Adv Drug Deliv Rev. 2007;59:505-21 pubmed
    b>Parasitic diseases such as malaria, leishmaniasis, and trypanosomiasis represent a significant global burden and pose a great challenge to drug discovery and delivery scientists due to their intracellular nature and disseminated locations...
  54. Hunt P. The human right to the highest attainable standard of health: new opportunities and challenges. Trans R Soc Trop Med Hyg. 2006;100:603-7 pubmed
    ..While human rights do not provide magic solutions, they have a constructive contribution to make. The failure to use them is a missed opportunity of major proportions...
  55. Singer B, De Castro M. Bridges to sustainable tropical health. Proc Natl Acad Sci U S A. 2007;104:16038-43 pubmed
    ..Many of the necessary surveillance components exist within separate animal- and human-oriented organizations. The challenge is to build the necessary bridges between them...
  56. Murray T, Cappello M. The molecular diagnosis of parasitic diseases. Pediatr Infect Dis J. 2008;27:163-4 pubmed publisher
  57. Molyneux D. Combating the "other diseases" of MDG 6: changing the paradigm to achieve equity and poverty reduction?. Trans R Soc Trop Med Hyg. 2008;102:509-19 pubmed publisher
    ..New paradigms are required if any impact on MDG 6 is to be achieved recognising the needs of the majority via an equitable distribution of funding...
  58. Vargas Villavicencio J, De León Nava M, Morales Montor J. Immunoendocrine mechanisms associated with resistance or susceptibility to parasitic diseases during pregnancy. Neuroimmunomodulation. 2009;16:114-21 pubmed publisher
    ..endocrine and immunologic factors have an impact on the pregnant female's susceptibility or resistance to parasitic diseases. There are three main mechanisms proposed to explain this susceptibility or resistance: (1) sex steroids ..
  59. Hotez P. A plan to defeat neglected tropical diseases. Sci Am. 2010;302:90-4, 96 pubmed
  60. Shin E, Guk S, Kim H, Lee S, Chai J. Trends in parasitic diseases in the Republic of Korea. Trends Parasitol. 2008;24:143-50 pubmed publisher
    ..This review focuses on trends in parasitic diseases in the Republic of Korea.
  61. Okwa O. Tropical parasitic diseases and women. Ann Afr Med. 2007;6:157-63 pubmed
    Tropical parasitic diseases constitute the greatest threat to the health and socio-economic status of women as a gender and social group...
  62. Ames P, Aloj G, Gentile F. Eosinophilia and thrombosis in parasitic diseases: an overview. Clin Appl Thromb Hemost. 2011;17:33-8 pubmed publisher
    It is known that peripheral blood eosinophilia (PBE) is a normal hematopoietic response to several parasitic diseases, but it is less known that PBE promotes a hypercoagulable state that may favor thrombosis...
  63. Carvalho J, Rodgers J, Atouguia J, Prazeres D, Monteiro G. DNA vaccines: a rational design against parasitic diseases. Expert Rev Vaccines. 2010;9:175-91 pubmed publisher
    b>Parasitic diseases are one of the most devastating causes of morbidity and mortality worldwide...