tympanic membrane perforation

Summary

Summary: A temporary or persistent opening in the eardrum (TYMPANIC MEMBRANE). Clinical signs depend on the size, location, and associated pathological condition.

Top Publications

  1. Rahman A, Olivius P, Dirckx J, von Unge M, Hultcrantz M. Stem cells and enhanced healing of chronic tympanic membrane perforation. Acta Otolaryngol. 2008;128:352-9 pubmed publisher
    ..This provides a basis for the exploration of stem cell treatment for TM perforations and holds promise for future improvements...
  2. Jung T, Kim Y, Kim Y, Park S, Martin D. Medial or medio-lateral graft tympanoplasty for repair of tympanic membrane perforation. Int J Pediatr Otorhinolaryngol. 2009;73:941-3 pubmed publisher
    ..To describe and evaluate the medio-lateral graft tympanoplasty(1) for the reconstruction of anterior or subtotal tympanic membrane (TM) perforation and medial graft tympanoplasty for posterior TM perforation...
  3. Gan R, Cheng T, Dai C, Yang F, Wood M. Finite element modeling of sound transmission with perforations of tympanic membrane. J Acoust Soc Am. 2009;126:243-53 pubmed publisher
    ..The FE model provides reasonable predictions on effects of perforation size and location on middle ear transfer function. The middle ear structure-function relationship can be revealed with multi-field coupled FE analysis...
  4. Karela M, Berry S, Watkins A, Phillipps J. Myringoplasty: surgical outcomes and hearing improvement: is it worth performing to improve hearing?. Eur Arch Otorhinolaryngol. 2008;265:1039-42 pubmed publisher
    ..Patients who undergo myringoplasty should be advised whilst been consented that there is a good chance of hearing improvement...
  5. Koc S, Akyuz S, Gurbuzler L, Aksakal C. Fat graft myringoplasty with the newly developed surgical technique for chronic tympanic membrane perforation. Eur Arch Otorhinolaryngol. 2013;270:1629-33 pubmed publisher
    ..Thirty consecutive patients with persistent tympanic membrane perforation were included in this study...
  6. Wang W, Lin Y. Minimally invasive inlay and underlay tympanoplasty. Am J Otolaryngol. 2008;29:363-6 pubmed publisher
  7. Lee H, Auo H, Kang J. Loop overlay tympanoplasty for anterior or subtotal perforations. Auris Nasus Larynx. 2010;37:162-6 pubmed publisher
    ..To report our experience with "loop overlay" tympanoplasty, a modified overlay technique with a superiorly based skin flap, for the reconstruction of anterior, subtotal or total tympanic membrane (TM) perforations...
  8. Lou Z, He J. A randomised controlled trial comparing spontaneous healing, gelfoam patching and edge-approximation plus gelfoam patching in traumatic tympanic membrane perforation with inverted or everted edges. Clin Otolaryngol. 2011;36:221-6 pubmed publisher
    To compare the outcome of patients with dry traumatic tympanic membrane perforation after spontaneous healing and gelfoam patching with or without perforation edge approximation.
  9. Venekamp R, Sanders S, Glasziou P, Del Mar C, Rovers M. Antibiotics for acute otitis media in children. Cochrane Database Syst Rev. 2013;:CD000219 pubmed publisher
    ..Acute otitis media (AOM) is one of the most common diseases in early infancy and childhood. Antibiotic use for AOM varies from 56% in the Netherlands to 95% in the USA, Canada and Australia...

More Information

Publications62

  1. Ibekwe T, Adeosun A, Nwaorgu O. Quantitative analysis of tympanic membrane perforation: a simple and reliable method. J Laryngol Otol. 2009;123:e2 pubmed publisher
    Accurate assessment of the features of tympanic membrane perforation, especially size, site, duration and aetiology, is important, as it enables optimum management.
  2. Matsuda Y, Kurita T, Ueda Y, Ito S, Nakashima T. Effect of tympanic membrane perforation on middle-ear sound transmission. J Laryngol Otol Suppl. 2009;:81-9 pubmed publisher
    b>Tympanic membrane perforation causes a sound conduction disturbance, and the size of this conduction disturbance is proportional to the perforation area...
  3. Maharjan M, Kafle P, Bista M, Shrestha S, Toran K. Observation of hearing loss in patients with chronic suppurative otitis media tubotympanic type. Kathmandu Univ Med J (KUMJ). 2009;7:397-401 pubmed
    It is acknowledged that size and site of tympanic membrane perforation is proportional to degree of hearing loss but there are many studies which suggests otherwise...
  4. Park M, Kim K, Lee J, Lee B. Repair of large traumatic tympanic membrane perforation with a Steri-Strips patch. Otolaryngol Head Neck Surg. 2011;145:581-5 pubmed publisher
    ..To investigate the effects of the Steri-Strips patch (3M) on the treatment of large traumatic tympanic membrane perforations (TMP)...
  5. Hakuba N, Iwanaga M, Tanaka S, Hiratsuka Y, Kumabe Y, Konishi M, et al. Basic fibroblast growth factor combined with atelocollagen for closing chronic tympanic membrane perforations in 87 patients. Otol Neurotol. 2010;31:118-21 pubmed publisher
    ..To present the clinical results of closing chronic tympanic membrane (TM) perforations using basic fibroblast growth factor (bFGF) combined with an atelocollagen/silicone bilayer membrane patch...
  6. Ritenour A, Wickley A, Ritenour J, Kriete B, Blackbourne L, Holcomb J, et al. Tympanic membrane perforation and hearing loss from blast overpressure in Operation Enduring Freedom and Operation Iraqi Freedom wounded. J Trauma. 2008;64:S174-8; discussion S178 pubmed publisher
    b>Tympanic membrane perforation is the most common primary blast injury in the current conflicts and occurs in approximately one tenth of service members wounded by combat explosions...
  7. Santa Maria P, Atlas M, Ghassemifar R. Chronic tympanic membrane perforation: a better animal model is needed. Wound Repair Regen. 2007;15:450-8 pubmed
    Developments in the treatment of chronic tympanic membrane perforation have been hindered by the lack of an ideal animal model...
  8. Lou Z, Tang Y, Yang J. A prospective study evaluating spontaneous healing of aetiology, size and type-different groups of traumatic tympanic membrane perforation. Clin Otolaryngol. 2011;36:450-60 pubmed publisher
    ..To evaluate the outcome of spontaneous healing of aetiology-, size- and type-different groups of acute traumatic eardrum perforation and to characterise changes in the morphology of the healing eardrum in various conditions...
  9. Li J, Eriksson P, Hansson A, Hellstrom S, Ny T. Plasmin/plasminogen is essential for the healing of tympanic membrane perforations. Thromb Haemost. 2006;96:512-9 pubmed
  10. Aggarwal R, Saeed S, Green K. Myringoplasty. J Laryngol Otol. 2006;120:429-32 pubmed
    ..This study reviews the factors thought to determine the likelihood of achieving complete closure of the tympanic membrane following surgical closure...
  11. Landsberg R, Fishman G, DeRowe A, Berco E, Berger G. Fat graft myringoplasty: results of a long-term follow-up. J Otolaryngol. 2006;35:44-7 pubmed
    ..To evaluate the long-term results of fat graft myringoplasty in adult and pediatric populations...
  12. Rahman A, Hultcrantz M, Dirckx J, Margolin G, von Unge M. Fresh tympanic membrane perforations heal without significant loss of strength. Otol Neurotol. 2005;26:1100-6 pubmed
    ..The mechanical and structural properties of the tympanic membrane change after a perforation has healed...
  13. Lerut B, Pfammatter A, Moons J, Linder T. Functional correlations of tympanic membrane perforation size. Otol Neurotol. 2012;33:379-86 pubmed publisher
    ..The correlation between tympanic membrane perforations and hearing loss was studied...
  14. Kanemaru S, Umeda H, Kitani Y, Nakamura T, Hirano S, Ito J. Regenerative treatment for tympanic membrane perforation. Otol Neurotol. 2011;32:1218-23 pubmed publisher
    To establish a tissue engineering therapy for the treatment of large tympanic membrane perforation (TMP) without the need for conventional surgical therapy.
  15. Hempel J, Becker A, Muller J, Krause E, Berghaus A, Braun T. Traumatic tympanic membrane perforations: clinical and audiometric findings in 198 patients. Otol Neurotol. 2012;33:1357-62 pubmed publisher
    ..To obtain clinical and audiometric findings in traumatic tympanic membrane perforations from a typical patient collective in a Western industrial nation because the appropriate data have an important relevance in medicolegal questions...
  16. Saliba I, Abela A, Arcand P. Tympanic membrane perforation: size, site and hearing evaluation. Int J Pediatr Otorhinolaryngol. 2011;75:527-31 pubmed publisher
    ..To assess different clinical scales of TM perforation size; to evaluate the effect of the size and the site of a perforation on the hearing level and frequencies...
  17. Lou Z. Healing large traumatic eardrum perforations in humans using fibroblast growth factor applied directly or via gelfoam. Otol Neurotol. 2012;33:1553-7 pubmed publisher
    ..The goal of this study was to evaluate the effects of conservative treatment and fibroblast growth factor (FGF) applied directly or via Gelfoam on the healing of large traumatic tympanic membrane perforations (TMPs) in humans...
  18. Ibekwe T, Ijaduola G, Nwaorgu O. Tympanic membrane perforation among adults in West Africa. Otol Neurotol. 2007;28:348-52 pubmed
    ..The knowledge of variations of the tympanic membrane (TM) perforations with the climatic changes in the West African subregion would help clinicians in its prevention and management...
  19. Sckolnick J, Mantle B, Li J, Chi D. Pediatric myringoplasty: factors that affect success-a retrospective study. Laryngoscope. 2008;118:723-9 pubmed publisher
    ..To evaluate the impact of patient and graft variables on the successful closure of tympanic membrane perforations treated with myringoplasty at the Children's Hospital of Pittsburgh from 2000 to 2005...
  20. Simons J, Eibling D. Tympanic membrane perforation and retained metal slag after a welding injury. Otolaryngol Head Neck Surg. 2005;133:635-6 pubmed
  21. Uyar Y, Keles B, Koc S, Ozturk K, Arbag H. Tympanoplasty in pediatric patients. Int J Pediatr Otorhinolaryngol. 2006;70:1805-9 pubmed
    ..The aim of this study is to analyze the clinical features and follow-up of a series of pediatric patients with chronic otitis media undergoing tymponaplasty surgery and to identify the effect of the factors on the course...
  22. Prestwich A, Li J, Eriksson P, Ny T, Berggren D, Hellstrom S. Lack of plasminogen does not alter the early inflammatory response following a tympanic membrane perforation: a study in plasminogen-deficient mice. Acta Otolaryngol. 2008;128:1294-302 pubmed publisher
  23. Leach A, Morris P, Mathews J. Compared to placebo, long-term antibiotics resolve otitis media with effusion (OME) and prevent acute otitis media with perforation (AOMwiP) in a high-risk population: a randomized controlled trial. BMC Pediatr. 2008;8:23 pubmed publisher
    ..For children at high risk of chronic suppurative otitis media (CSOM), strategies to prevent acute otitis media with perforation (AOMwiP) may reduce progression to CSOM...
  24. Lou Z, Hu Y, Tang Y. Prognosis and outcome of the tympanic membrane flap at traumatic tympanic membrane perforation edge. ORL J Otorhinolaryngol Relat Spec. 2011;73:212-8 pubmed publisher
    ..Chart records of 329 patients with a single ear traumatic tympanic membrane perforation were retrieved and analyzed...
  25. Orji F, Agu C. Determinants of spontaneous healing in traumatic perforations of the tympanic membrane. Clin Otolaryngol. 2008;33:420-6 pubmed publisher
    To analyse the various factors influencing spontaneous healing of traumatic tympanic membrane perforation in West Africa.
  26. Conoyer J, Kaylie D, Jackson C. Otologic surgery following ear trauma. Otolaryngol Head Neck Surg. 2007;137:757-61 pubmed
    ..To investigate common presentations and expected outcomes in patients with traumatically induced otologic dysfunction...
  27. Voss S, Rosowski J, Merchant S, Peake W. Non-ossicular signal transmission in human middle ears: Experimental assessment of the "acoustic route" with perforated tympanic membranes. J Acoust Soc Am. 2007;122:2135-53 pubmed
    ..Some features of the frequency dependence of H(P(CAV) ) and H(WPD) can be interpreted in terms of a structure-based lumped-element acoustic model of the perforation and middle-ear cavities...
  28. Matanda R, Muyunga K, Sabue M, Creten W, Van de Heyning P. Chronic suppurative otitis media and related complications at the University Clinic of Kinshasa. B-ENT. 2005;1:57-62 pubmed
    ..Our data suggest that the prevalence of CSOM in the Kinshasa area is at least 4% and, in fact, has not declined over the last 20 years...
  29. Morris P, Leach A, Silberberg P, Mellon G, Wilson C, Hamilton E, et al. Otitis media in young Aboriginal children from remote communities in Northern and Central Australia: a cross-sectional survey. BMC Pediatr. 2005;5:27 pubmed
    ..The aim of the study was to determine the prevalence of middle ear disease (otitis media) in a high-risk population of young Aboriginal children from remote communities in Northern and Central Australia...
  30. Ishimoto S, Ishibashi T, Bottaro D, Kaga K. Direct application of keratinocyte growth factor, basic fibroblast growth factor and transforming growth factor-alpha during healing of tympanic membrane perforation in glucocorticoid-treated rats. Acta Otolaryngol. 2002;122:468-73 pubmed
    ..Only KGF, therefore, improved epidermal migration in the TM, while all the growth factors tested induced hyperplasia in the TM...
  31. Jung T, Park S. Mediolateral graft tympanoplasty for anterior or subtotal tympanic membrane perforation. Otolaryngol Head Neck Surg. 2005;132:532-6 pubmed
    ..To describe and evaluate the mediolateral graft tympanoplasty for the reconstruction of anterior or subtotal tympanic membrane (TM) perforation...
  32. Voss S, Rosowski J, Merchant S, Peake W. How do tympanic-membrane perforations affect human middle-ear sound transmission?. Acta Otolaryngol. 2001;121:169-73 pubmed
    ..A quantitative model predicts the influence of middle-ear air-space volume on loss; with larger volumes, loss is smaller...
  33. Singh M, Rai A, Bandyopadhyay S, Gupta S. Comparative study of the underlay and overlay techniques of myringoplasty in large and subtotal perforations of the tympanic membrane. J Laryngol Otol. 2003;117:444-8 pubmed
    ..8 per cent vs 57.1 per cent) and fewer minor complications (6.6 per cent vs 33.3 per cent)...
  34. Pignataro L, Grillo Della Berta L, Capaccio P, Zaghis A. Myringoplasty in children: anatomical and functional results. J Laryngol Otol. 2001;115:369-73 pubmed
    ..The status of the middle ear (i.e. the presence of a dry ear), significantly improves surgical outcome; and so careful inflammatory changes in the middle-ear mucosa should be evaluated and medical treatment considered before surgery...
  35. Sprem N, Branica S, Dawidowsky K. Tympanoplasty after war blast lesions of the eardrum: retrospective study. Croat Med J. 2001;42:642-5 pubmed
    ..To establish whether hearing loss after eardrum blast injury could be recovered by tympanoplasty performed immediately after injury and what material is the most suitable for eardrum closure...
  36. Lee P, Kelly G, Mills R. Myringoplasty: does the size of the perforation matter?. Clin Otolaryngol Allied Sci. 2002;27:331-4 pubmed
    ..039) in successful myringoplasties, a positive value indicating an improvement in hearing. This change is unlikely to be clinically significant. Patients should be made aware of these facts when informed consent is being obtained...
  37. Ma Y, Zhao H, Zhou X. Topical treatment with growth factors for tympanic membrane perforations: progress towards clinical application. Acta Otolaryngol. 2002;122:586-99 pubmed
  38. Guneri E, Tekin S, Yilmaz O, Ozkara E, Erdag T, Ikiz A, et al. The effects of hyaluronic acid, epidermal growth factor, and mitomycin in an experimental model of acute traumatic tympanic membrane perforation. Otol Neurotol. 2003;24:371-6 pubmed
    ..The goal of this study was to evaluate the effects of hyaluronic acid, epidermal growth factor, and mitomycin C on the healing of acute experimental traumatic perforations of the tympanic membrane...
  39. Walther L, Gudziol H, Beleites E. [Selective stimulation of the equilibrium organ using monochromatic near infrared]. Laryngorhinootologie. 2004;83:88-95 pubmed
  40. Dornhoffer J. Cartilage tympanoplasty: indications, techniques, and outcomes in a 1,000-patient series. Laryngoscope. 2003;113:1844-56 pubmed
    ..Our hypothesis was that pathology and status of the ossicular chain should dictate the technique used to achieve optimal outcome...
  41. Kartush J, Michaelides E, Becvarovski Z, LaRouere M. Over-under tympanoplasty. Laryngoscope. 2002;112:802-7 pubmed
    ..The over-under tympanoplasty, an innovative method for tympanic membrane repair, will be described as a reliable alternative that has advantages over traditional procedures...
  42. Umapathy N, Dekker P. Myringoplasty: is it worth performing in children?. Arch Otolaryngol Head Neck Surg. 2003;129:1053-5 pubmed
    ..To evaluate the results of myringoplasty in children 4 to 14 years old at the time of surgery...
  43. Walther L, Schmidt W, Gudziol H, Scheibe A, Scheiding B, Rössler B, et al. [Near infrared stimulation of the equilibrium organ--first clinical experiences]. Laryngorhinootologie. 2003;82:687-92 pubmed
    ..This method should be examined within the framework of a pilot study, evaluated and its clinical possible applications examined...
  44. Gibney K, Morris P, Carapetis J, Skull S, Smith Vaughan H, Stubbs E, et al. The clinical course of acute otitis media in high-risk Australian Aboriginal children: a longitudinal study. BMC Pediatr. 2005;5:16 pubmed
    ..Our aim was to describe the clinical course of AOM and the associated bacterial nasopharyngeal colonisation in a high-risk population of Australian Aboriginal children...
  45. Onal K, Uguz M, Kazikdas K, Gursoy S, Gokce H. A multivariate analysis of otological, surgical and patient-related factors in determining success in myringoplasty. Clin Otolaryngol. 2005;30:115-20 pubmed
    ..The aim of this study was to evaluate the effects of smoking and other prognostic factors on long-term surgical outcome and hearing results in myringoplasty...
  46. Spiegel J, Kessler J. Tympanic membrane perforation repair with acellular porcine submucosa. Otol Neurotol. 2005;26:563-6 pubmed
    ..In this study, we examined the use of small intestine submucosa in the repair of chronic tympanic membrane perforations in a chinchilla model...
  47. Voss S, Rosowski J, Merchant S, Peake W. Middle-ear function with tympanic-membrane perforations. I. Measurements and mechanisms. J Acoust Soc Am. 2001;110:1432-44 pubmed
    ..The quantitative description of perforation-induced losses may help clinicians determine, in an ear with a perforation, whether poor hearing results only from the perforation or whether other pathology should be expected...
  48. Black R, Cousins V, Chapman P, Becvarovski Z, Coates H, O Leary S, et al. Ototoxic ear drops with grommet and tympanic membrane perforations: a position statement. Med J Aust. 2007;186:605-6 pubmed
  49. Ikezono T, Shindo S, Sekine K, Shiiba K, Matsuda H, Kusama K, et al. Cochlin-tomoprotein (CTP) detection test identifies traumatic perilymphatic fistula due to penetrating middle ear injury. Acta Otolaryngol. 2011;131:937-44 pubmed publisher
    ..The cochlin-tomoprotein (CTP) detection test can be used to make a definite, objective diagnosis of traumatic perilymphatic fistula (PLF), and therefore offers valuable information on patient selection for surgical treatment...
  50. Tahar Aissa J, Hultcrantz M. Acute tympanic membrane perforations and the early immunological response in rats. Acta Otolaryngol. 2009;129:1192-7 pubmed publisher
    ..B cells, and T cells occurred at different frequencies, localizations, and times after acute laser tympanic membrane perforation. Immunological cells were most prevalent in the proliferative mass adjacent to the annulus region...
  51. Boronat Echeverría N, Reyes García E, Sevilla Delgado Y, Aguirre Mariscal H, Mejia Arangure J. Prognostic factors of successful tympanoplasty in pediatric patients: a cohort study. BMC Pediatr. 2012;12:67 pubmed publisher
  52. Ramalho J, Bento R. Healing of subacute tympanic membrane perforations in chinchillas treated with epidermal growth factor and pentoxifylline. Otol Neurotol. 2006;27:720-7 pubmed
  53. Henry J. When the envelope pushes back: a combat aviator experiences barotrauma after descending with an ear block. Mil Med. 2008;173:403-5 pubmed
    ..This resulted in a tympanic membrane perforation and the medical grounding of the member for 10 days...