otitis media with effusion

Summary

Summary: Inflammation of the middle ear with a clear pale yellow-colored transudate.

Top Publications

  1. Scholz F, Kohn A, Rissmann A, Arens C, Vorwerk W, Vorwerk U. [Otitis media with effusion : frequency, diagnosis, and therapy in early childhood]. HNO. 2013;61:859-65 pubmed publisher
    b>Otitis media with effusion (OME) as the most common cause of hearing loss in childhood plays an important role in the follow-up after failed newborn hearing screening (NHS)...
  2. Harman N, Bruce I, Callery P, Tierney S, Sharif M, O BRIEN K, et al. MOMENT--Management of Otitis Media with Effusion in Cleft Palate: protocol for a systematic review of the literature and identification of a core outcome set using a Delphi survey. Trials. 2013;14:70 pubmed publisher
    Cleft palate (CP) has an incidence of approximately 1 in 700. Children with CP are also susceptible to otitis media with effusion (OME), with approximately 90% experiencing nontrivial OME...
  3. Zelazowska Rutkowska B, Wysocka J, Skotnicka B. Chosen factors of T and B cell apoptosis in hypertrophic adenoid in children with otitis media with effusion. Int J Pediatr Otorhinolaryngol. 2010;74:698-700 pubmed publisher
    ..Adenoid excised due to hypertrophy with or without chronic otitis media with effusion was used as study material...
  4. Martines F, Martinciglio G, Martines E, Bentivegna D. The role of atopy in otitis media with effusion among primary school children: audiological investigation. Eur Arch Otorhinolaryngol. 2010;267:1673-8 pubmed publisher
    The objective of this study was to evaluate the role of atopy in otitis media with effusion (OME) in children attending primary school in western Sicily focusing on the audiological characteristics among atopic and non-atopic subjects ..
  5. van Zon A, van der Heijden G, Van Dongen T, Burton M, Schilder A. Antibiotics for otitis media with effusion in children. Cochrane Database Syst Rev. 2012;:CD009163 pubmed publisher
    b>Otitis media with effusion (OME) is characterised by an accumulation of fluid in the middle ear behind an intact tympanic membrane, without the symptoms or signs of acute infection...
  6. Jang C, Park H, Choi C, Cho Y, Park I. Efficacy of transnasal nebulized surfactant on experimental otitis media with effusion in guinea pig. Int J Pediatr Otorhinolaryngol. 2010;74:71-4 pubmed publisher
    ..trials have demonstrated that nebulized natural surfactant is effective in the treatment of experimental otitis media with effusion (OME)...
  7. Gunasekera H, O Connor T, Vijayasekaran S, Del Mar C. Primary care management of otitis media among Australian children. Med J Aust. 2009;191:S55-9 pubmed
    ..Evidence for corticosteroids, topical analgesia and xylitol are scant. Otitis media with effusion (OME) is diagnosed as the presence of middle ear effusion (type B tympanogram or immobile tympanic ..
  8. Campbell R, Birman C, Morgan L. Management of otitis media with effusion in children with primary ciliary dyskinesia: a literature review. Int J Pediatr Otorhinolaryngol. 2009;73:1630-8 pubmed publisher
    ..some of the most common symptoms of primary ciliary dyskinesia including chronic rhinitis, sinusitis and otitis media with effusion. A dilemma for otorhinolaryngologists is whether ventilation tubes are of benefit in children with ..
  9. Lack G, Caulfield H, Penagos M. The link between otitis media with effusion and allergy: a potential role for intranasal corticosteroids. Pediatr Allergy Immunol. 2011;22:258-66 pubmed publisher
    We reviewed the evidence linking otitis media with effusion (OME) and atopy, with the goal of clarifying the possible role of intranasal corticosteroids (INSs) in OME treatment...

More Information

Publications62

  1. Hong W, Juneau R, Pang B, Swords W. Survival of bacterial biofilms within neutrophil extracellular traps promotes nontypeable Haemophilus influenzae persistence in the chinchilla model for otitis media. J Innate Immun. 2009;1:215-24 pubmed publisher
    ..These data support the conclusion that NTHi subverts neutrophil extracellular traps to persist in vivo. These data also indicate that a more inclusive definition for biofilms may be warranted...
  2. Williamson I, Benge S, Barton S, Petrou S, Letley L, Fasey N, et al. Topical intranasal corticosteroids in 4-11 year old children with persistent bilateral otitis media with effusion in primary care: double blind randomised placebo controlled trial. BMJ. 2009;339:b4984 pubmed publisher
    To determine the clinical effectiveness of topical intranasal corticosteroids in children with bilateral otitis media with effusion.
  3. Williamson I, Benge S, Barton S, Petrou S, Letley L, Fasey N, et al. A double-blind randomised placebo-controlled trial of topical intranasal corticosteroids in 4- to 11-year-old children with persistent bilateral otitis media with effusion in primary care. Health Technol Assess. 2009;13:1-144 pubmed publisher
    To determine the clinical effectiveness and cost-effectiveness of topical mometasone in children with bilateral otitis media with effusion (OME).
  4. Noben Trauth K, Latoche J. Ectopic mineralization in the middle ear and chronic otitis media with effusion caused by RPL38 deficiency in the Tail-short (Ts) mouse. J Biol Chem. 2011;286:3079-93 pubmed publisher
    ..deposition of cholesterol crystals in the middle ear cavity, enlarged Eustachian tube, and chronic otitis media with effusion all beginning at around 3 weeks after birth...
  5. Wang M, Huang C, Wang Y, Chien C. Effects of increased payment for ventilation tube insertion on decision making for paediatric otitis media with effusion. J Eval Clin Pract. 2012;18:919-22 pubmed publisher
    ..5 to $117.6 in July 2004. This study aimed to evaluate if the increased payment affected the decision making of physicians...
  6. Marchica C, Pitaro J, Daniel S. Recurrent tube insertion for chronic otitis media with effusion in children over 6 years. Int J Pediatr Otorhinolaryngol. 2013;77:252-5 pubmed publisher
    The purpose of this study is to identify the clinical characteristics of children above 6 years of age with chronic otitis media with effusion (COME) who have required pressure equalizing tube (PET) insertions.
  7. Chen W, Allen E, Mychaleckyj J, Chen F, Hou X, Rich S, et al. Significant linkage at chromosome 19q for otitis media with effusion and/or recurrent otitis media (COME/ROM). BMC Med Genet. 2011;12:124 pubmed publisher
    ..analyses, we identified a region of chromosome 19 as harboring a susceptibility locus for chronic otitis media with effusion and/or recurrent otitis media (COME/ROM)...
  8. Daniel M, Imtiaz Umer S, Fergie N, Birchall J, Bayston R. Bacterial involvement in otitis media with effusion. Int J Pediatr Otorhinolaryngol. 2012;76:1416-22 pubmed publisher
    b>Otitis media with effusion (OME), a common chronic childhood condition affecting hearing, is thought to be a result of bacterial infection, with biofilms recently implicated...
  9. Stol K, Verhaegh S, Graamans K, Engel J, Sturm P, Melchers W, et al. Microbial profiling does not differentiate between childhood recurrent acute otitis media and chronic otitis media with effusion. Int J Pediatr Otorhinolaryngol. 2013;77:488-93 pubmed publisher
    ..of childhood, with a minority of children suffering from recurrent acute otitis media (rAOM) or chronic otitis media with effusion (COME), both of which are associated with significant morbidity...
  10. Sekiyama K, Ohori J, Matsune S, Kurono Y. The role of vascular endothelial growth factor in pediatric otitis media with effusion. Auris Nasus Larynx. 2011;38:319-24 pubmed publisher
    ..VEGF messenger ribonucleic acid (mRNA) is expressed in the middle ear in an experimental animal model of otitis media with effusion (OME) and in patients with OME...
  11. Kerschner J, Hong W, Taylor S, Kerschner J, Khampang P, Wrege K, et al. A novel model of spontaneous otitis media with effusion (OME) in the Oxgr1 knock-out mouse. Int J Pediatr Otorhinolaryngol. 2013;77:79-84 pubmed publisher
    ..a G protein coupled receptor (GPCR) encoded by the Oxgr1 gene results in a predisposition to spontaneous otitis media with effusion. As a primary component of interest in OME, mucin expression was examined in this model to assess ..
  12. Park C, Chung J, Min H, Kim K, Tae K, Cho S, et al. Helicobacter pylori in middle ear of children with otitis media with effusion. Chin Med J (Engl). 2011;124:4275-8 pubmed
    b>Otitis media with effusion (OME) is a common pediatric disease, but its pathogenesis remains uncertain. The relationship between OME and Helicobacter pylori (HP) is currently being studied, and a relationship has not yet been confirmed...
  13. D Alatri L, Picciotti P, Marchese M, Fiorita A. Alternative treatment for otitis media with effusion: eustachian tube rehabilitation. Acta Otorhinolaryngol Ital. 2012;32:26-30 pubmed
    In this study, we evaluated the effectiveness of eustachian tube rehabilitation (ETR) as treatment for otitis media with effusion (OME). Thirty-five children with persistent OME were enrolled...
  14. . Adjuvant adenoidectomy in persistent bilateral otitis media with effusion: hearing and revision surgery outcomes through 2 years in the TARGET randomised trial. Clin Otolaryngol. 2012;37:107-16 pubmed publisher
    To determine the adjuvant effects of adenoidectomy with short-stay ventilation tubes to hearing and revision surgery in children over 3.5 years with persistent otitis media with effusion.
  15. Guvenc M, Midilli K, Inci E, Kuşkucu M, Tahamiler R, Ozergil E, et al. Lack of Chlamydophila pneumoniae and predominance of Alloiococcus otitidis in middle ear fluids of children with otitis media with effusion. Auris Nasus Larynx. 2010;37:269-73 pubmed publisher
    To investigate the presence of Chlamydophila pneumoniae and other bacterial pathogens in middle ear effusion samples obtained from children with otitis media with effusion (OME).
  16. Griffin G, Flynn C. Antihistamines and/or decongestants for otitis media with effusion (OME) in children. Cochrane Database Syst Rev. 2011;:CD003423 pubmed publisher
    This is an update of a Cochrane Review first published in The Cochrane Library in Issue 4, 2006.Otitis media with effusion (OME) is common and may cause hearing loss with associated developmental delay. Treatment remains controversial...
  17. Ungkanont K, Charuluxananan S, Komoltri C. Association of otoscopic findings and hearing level in pediatric patients with otitis media with effusion. Int J Pediatr Otorhinolaryngol. 2010;74:1063-6 pubmed publisher
    To find the association between the abnormalities of tympanic membrane characteristics and the hearing level in pediatric patients with otitis media with effusion.
  18. Rezes S, Soderlund Venermo M, Roivainen M, Kemppainen K, Szabo Z, Sziklai I, et al. Human bocavirus and rhino-enteroviruses in childhood otitis media with effusion. J Clin Virol. 2009;46:234-7 pubmed publisher
    Viral respiratory infections play an important role in the pathogenesis of otitis media with effusion (OME) in children...
  19. Dragicević D, Vlaski L, Komazec Z, Jović R. Transient evoked otoacoustic emissions in young children with otitis media with effusion before and after surgery. Auris Nasus Larynx. 2010;37:281-5 pubmed publisher
    b>Otitis media with effusion (OME) is one of the commonest causes of acquired hearing loss in children with increasing incidence...
  20. Khoramrooz S, Mirsalehian A, Emaneini M, Jabalameli F, Aligholi M, Saedi B, et al. Frequency of Alloicoccus otitidis, Streptococcus pneumoniae, Moraxella catarrhalis and Haemophilus influenzae in children with otitis media with effusion (OME) in Iranian patients. Auris Nasus Larynx. 2012;39:369-73 pubmed publisher
    To determine the presence of common bacterial agents of otitis media with effusion (OME), together with investigation these agent in the adenoid tissue and antimicrobial susceptibility pattern of isolated bacteria in Iranian children with ..
  21. Kim M, Park D, Shim J, Jung H, Park M, Kim Y, et al. TLR-9, NOD-1, NOD-2, RIG-I and immunoglobulins in recurrent otitis media with effusion. Int J Pediatr Otorhinolaryngol. 2010;74:1425-9 pubmed publisher
    ..in middle ear infections and whether the expression of PRRs and immunoglobulins is correlated in recurrent otitis media with effusion (OME). We therefore investigated the expression of PRRs and immunoglobulins in children with OME.
  22. Flynn T, Moller C, Jönsson R, Lohmander A. The high prevalence of otitis media with effusion in children with cleft lip and palate as compared to children without clefts. Int J Pediatr Otorhinolaryngol. 2009;73:1441-6 pubmed publisher
    Children with cleft lip and palate universally present with otitis media with effusion. This prevalence has not been systematically studied...
  23. Aynali G, Yariktas M, Yasan H, Karahan N, Baspinar S, Tuz M, et al. The effects of methylprednisolone, montelukast and indomethacine in experimental otitis media with effusion. Int J Pediatr Otorhinolaryngol. 2011;75:15-9 pubmed publisher
    The present study aimed to investigate the effects of indomethacine, montelukast and methylprednisolone in management of experimental otitis media with effusion.
  24. Sale M, Chen W, Weeks D, Mychaleckyj J, Hou X, Marion M, et al. Evaluation of 15 functional candidate genes for association with chronic otitis media with effusion and/or recurrent otitis media (COME/ROM). PLoS ONE. 2011;6:e22297 pubmed publisher
    ..in the innate immune response and secondary response to infection may confer susceptibility to chronic otitis media with effusion and/or recurrent otitis media (COME/ROM)...
  25. Xu Q, Kaur R, Casey J, Adlowitz D, Pichichero M, Zeng M. Identification of Streptococcus pneumoniae and Haemophilus influenzae in culture-negative middle ear fluids from children with acute otitis media by combination of multiplex PCR and multi-locus sequencing typing. Int J Pediatr Otorhinolaryngol. 2011;75:239-44 pubmed publisher
    ..This study aimed to develop a combined molecular method to accurately detect these otopathogens...
  26. Martines F, Bentivegna D, Maira E, Sciacca V, Martines E. Risk factors for otitis media with effusion: case-control study in Sicilian schoolchildren. Int J Pediatr Otorhinolaryngol. 2011;75:754-9 pubmed publisher
    To identify the prevalence and demographic, maternal and child risk factors for otitis media with effusion (OME) in Sicilian schoolchildren and analyse the results with reference to the review of the literature.
  27. Preciado D, Goyal S, Rahimi M, Watson A, Brown K, Hathout Y, et al. MUC5B Is the predominant mucin glycoprotein in chronic otitis media fluid. Pediatr Res. 2010;68:231-6 pubmed publisher
    ..4-fold increased signal in MUC5B when compared with MUC5AC (p = 0.0009). In summary, although both MUC5AC and MUC5B mucins are detected in middle ear effusions, MUC5B seems to be predominant mucin present in COM secretions...
  28. Lee D. How to improve the accuracy of diagnosing otitis media with effusion in a pediatric population. Int J Pediatr Otorhinolaryngol. 2010;74:151-3 pubmed publisher
    To determine the accuracy of pneumatic otoscopy, a tympanogram and otomicroscopy for diagnosing otitis media with effusion (OME) in a pediatric population.
  29. Yaman H, Yilmaz S, Alkan N, Subasi B, Guclu E, Ozturk O. Shepard grommet tympanostomy tube complications in children with chronic otitis media with effusion. Eur Arch Otorhinolaryngol. 2010;267:1221-4 pubmed publisher
    The objective of this study was to determine tympanostomy tube complications in children with chronic otitis media with effusion who were treated with Shepard grommet tympanostomy tube insertion...
  30. Zhao S, Li J, Liu H, Zhang Q, Wang Y, Han D. Role of interleukin-10 and transforming growth factor beta 1 in otitis media with effusion. Chin Med J (Engl). 2009;122:2149-54 pubmed
    b>Otitis media with effusion (OME) is a disease with complicated pathogeneses which are not clearly known. Increasing interest has been focused on immunological cells, cytokines and their roles in chronic inflammatory states...
  31. Eser O, Ipci K, Alp S, Akyol U, Unal O, Hascelik G, et al. Efficacy of nasopharyngeal culture in identification of pathogen in middle ear fluid in chronic otitis media with effusion. Indian J Med Microbiol. 2009;27:237-41 pubmed publisher
    Chronic otitis media with effusion (OME) is the leading cause of hearing loss during childhood...
  32. Souter M, Mills N, Mahadevan M, Douglas G, Ellwood P, Asher M, et al. The prevalence of atopic symptoms in children with otitis media with effusion. Otolaryngol Head Neck Surg. 2009;141:104-7 pubmed publisher
    To determine the prevalence of allergic symptoms in children with otitis media with effusion (OME).
  33. Petrou S, Dakin H, Abangma G, Benge S, Williamson I. Cost-utility analysis of topical intranasal steroids for otitis media with effusion based on evidence from the GNOME trial. Value Health. 2010;13:543-51 pubmed publisher
    To estimate the cost-effectiveness of topical intranasal steroids for the treatment of otitis media with effusion (OME) in primary care from the perspective of the UK National Health Service.
  34. Dewey C, Midgeley E, Maw R. The relationship between otitis media with effusion and contact with other children in a british cohort studied from 8 months to 3 1/2 years. The ALSPAC Study Team. Avon Longitudinal Study of Pregnancy and Childhood. Int J Pediatr Otorhinolaryngol. 2000;55:33-45 pubmed
    It is generally acknowledged that otitis media with effusion is more prevalent among children attending grouped day care...
  35. Rovers M, Straatman H, Ingels K, Van Der Wilt G, van den Broek P, Zielhuis G. The effect of ventilation tubes on language development in infants with otitis media with effusion: A randomized trial. Pediatrics. 2000;106:E42 pubmed
    To study the effectiveness of ventilation tubes on the language development in infants with persistent otitis media with effusion (OME). All existing studies addressed children 3 years of age or older...
  36. Kouwen H, Dejonckere P. Prevalence of OME is reduced in young children using chewing gum. Ear Hear. 2007;28:451-5 pubmed
    The present study investigates a possible relationship between use of chewing gum and otitis media with effusion (OME) in children...
  37. Caye Thomasen P, Stangerup S, Jørgensen G, Drozdziewic D, Bonding P, Tos M. Myringotomy versus ventilation tubes in secretory otitis media: eardrum pathology, hearing, and eustachian tube function 25 years after treatment. Otol Neurotol. 2008;29:649-57 pubmed publisher
    ..The included children were treated by myringotomy on the left ear and ventilation tube insertion on the right ear...
  38. Sichel J, Priner Y, Weiss S, Levi H, Barshtein G, Eliashar R, et al. Characteristics of the type B tympanogram can predict the magnitude of the air-bone gap in otitis media with effusion. Ann Otol Rhinol Laryngol. 2003;112:450-4 pubmed
    ..0025; pressure, p < .025; and area under the curve, p < .0005). Tympanometry may be used as an objective measure to estimate the extent of conductive hearing loss, especially in young children...
  39. Lazaridis E, Saunders J. Can you hear me now? A genetic model of otitis media with effusion. J Clin Invest. 2008;118:471-4 pubmed publisher
    b>Otitis media with effusion (OME) is characterized by the occurrence of fluid in the middle-ear cavity in the absence of any signs of acute ear infection and occurs most frequently in children with auditory or eustachian tube dysfunction...
  40. Yaman H, Ozturk K, Uyar Y, Gurbilek M. Effectiveness of corticosteroids in otitis media with effusion: an experimental study. J Laryngol Otol. 2008;122:25-30 pubmed
    The aim of the present study was to investigate the dose-related effectiveness of corticosteroids in the management of otitis media with effusion, by using the objective assessment techniques of tympanometry and cytokine measurement.
  41. Richards M, Giannoni C. Quality-of-life outcomes after surgical intervention for otitis media. Arch Otolaryngol Head Neck Surg. 2002;128:776-82 pubmed
    To assess the change in disease-specific quality of life in children with recurrent acute otitis media and/or chronic otitis media with effusion treated with surgical intervention.
  42. Kariya S, Okano M, Aoji K, Kosaka M, Chikumoto E, Hattori H, et al. Role of macrophage migration inhibitory factor in otitis media with effusion in adults. Clin Diagn Lab Immunol. 2003;10:417-22 pubmed
    b>Otitis media with effusion (OME) is one of the most common ear diseases...
  43. Rovers M, Black N, Browning G, Maw R, Zielhuis G, Haggard M. Grommets in otitis media with effusion: an individual patient data meta-analysis. Arch Dis Child. 2005;90:480-5 pubmed
    To identify subgroups of children with otitis media with effusion (OME) that might benefit more than others from treatment with ventilation tubes.
  44. Kariya S, Okano M, Hattori H, Sugata Y, Matsumoto R, Fukushima K, et al. TH1/TH2 and regulatory cytokines in adults with otitis media with effusion. Otol Neurotol. 2006;27:1089-93 pubmed
    b>Otitis media with effusion is one of the most common and intractable ear diseases. However, the role of Th1, Th2, and immunoregulatory cytokines on the pathogenesis of the disease in adult patients remains to be determined...
  45. Sagai S, Suetake M, Yano H, Yoshida M, Ohyama K, Endo H, et al. Relationship between respiratory syncytial virus infection and acute otitis media in children. Auris Nasus Larynx. 2004;31:341-5 pubmed
    ..However, there are only a few reports about AOM associated with RSV infection...
  46. Leskinen K, Hendolin P, Virolainen Julkunen A, Ylikoski J, Jero J. Alloiococcus otitidis in acute otitis media. Int J Pediatr Otorhinolaryngol. 2004;68:51-6 pubmed
    The bacterium Alloiococcus otitidis has been found to be associated with otitis media with effusion (OME)...
  47. Stenstrom R, Pless I, Bernard P. Hearing thresholds and tympanic membrane sequelae in children managed medically or surgically for otitis media with effusion. Arch Pediatr Adolesc Med. 2005;159:1151-6 pubmed
    To determine the long-term effects of ventilation tube insertion on hearing thresholds and tympanic membrane pathologic abnormalities in children with otitis media with effusion.
  48. Testa B, Testa D, Mesolella M, D Errico G, Tricarico D, Motta G. Management of chronic otitis media with effusion: the role of glutathione. Laryngoscope. 2001;111:1486-9 pubmed
    The inflammatory cells documented in chronic otitis media with effusion (OME) spontaneously release oxidants which can induce middle ear (ME) epithelial cell damage...
  49. Bellussi L, Mandala M, Passali F, Passali G, Lauriello M, Passali D. Quality of life and psycho-social development in children with otitis media with effusion. Acta Otorhinolaryngol Ital. 2005;25:359-64 pubmed
    ..Inventory is a suitable test to differentiate state anxiety caused by a specific event [in this case, otitis media with effusion (OME)] from a trait anxiety (anxious personality) in parents and caregivers...
  50. Serbetcioglu B, Ugurtay O, Kirkim G, Mutlu B. No association between hearing loss due to bilateral otitis media with effusion and Denver-II test results in preschool children. Int J Pediatr Otorhinolaryngol. 2008;72:215-22 pubmed
    b>Otitis media with effusion (OME) is the most common cause of acquired hearing loss in childhood and has been associated with delayed language development and behavioral problems...
  51. Revai K, Patel J, Grady J, Chonmaitree T. Tympanometric findings in young children during upper respiratory tract infections with and without acute otitis media. Pediatr Infect Dis J. 2008;27:292-5 pubmed publisher
    ..Children younger than 2 years of age are at highest risk for AOM compared with older children and adults. There has been no published study comparing the middle ear status during URI in infants and young children by age group...
  52. Abdullah B, Hassan S, Sidek D, Jaafar H. Adenoid mast cells and their role in the pathogenesis of otitis media with effusion. J Laryngol Otol. 2006;120:556-60 pubmed
    b>Otitis media with effusion (OME) is an inflammation of the middle ear in which a collection of liquid is present in the middle-ear space while the tympanic membrane is intact...
  53. Koten M, Uzun C, Yagiz R, Adali M, Karasalihoglu A, Tatman Otkun M, et al. Nebulized surfactant as a treatment choice for otitis media with effusion: an experimental study in the rabbit. J Laryngol Otol. 2001;115:363-8 pubmed
    Exogenous surfactant can improve eustachian tube function in experimentally induced otitis media with effusion (OME)...