cochlear diseases


Summary: Pathological processes of the snail-like structure (COCHLEA) of the inner ear (LABYRINTH) which can involve its nervous tissue, blood vessels, or fluid (ENDOLYMPH).

Top Publications

  1. Oertel R, Kirch W, Klemm E. Prednisolone concentration in the cochlea of patients with perilymph fistula. Pharmazie. 2007;62:239-40 pubmed
    ..Mean concentrations of prednisolone in the perilymphe reached 95 ng/ml after 15-25 min, and 338 ng/ml after 30-45 min. The values reached 8 and 41% of the corresponding serum concentrations, respectively. ..
  2. Kalinec G, Webster P, Lim D, Kalinec F. A cochlear cell line as an in vitro system for drug ototoxicity screening. Audiol Neurootol. 2003;8:177-89 pubmed
    ..This cell line may be an excellent in vitro system to investigate the cellular and molecular mechanisms involved in ototoxicity and for screening of the potential ototoxicity or otoprotective properties of new pharmacological drugs...
  3. Szirmai A, Küstel M, Panczel G, Kocher I, Repassy G, Nagy Z. Evidences of vascular origin of cochleovestibular dysfunction. Acta Neurol Scand. 2001;104:68-71 pubmed
  4. Li Duan M, Bordet T, Mezzina M, Kahn A, Ulfendahl M. Adenoviral and adeno-associated viral vector mediated gene transfer in the guinea pig cochlea. Neuroreport. 2002;13:1295-9 pubmed
    ..Present findings will help to develop future gene therapy protocols in the inner ear by using Ad and AAV coding for neurotrophins such as NT-3, BDNF, GDNF and VEGF. ..
  5. Takeshita T, Iwasaki S, Nagura M, Watanabe T, Umemura K, Hoshino T. Photochemically induced double lateral wall lesions in the guinea pig cochlea. Acta Otolaryngol. 2003;123:355-61 pubmed
  6. Maetani T, Hakuba N, Taniguchi M, Hyodo J, Shimizu Y, Gyo K. Free radical scavenger protects against inner hair cell loss after cochlear ischemia. Neuroreport. 2003;14:1881-4 pubmed
    ..By contrast, in animals treated with edaravone, the threshold shift was 7.5 dB and only 8.8% of IHCs was lost. These results suggest that edaravone protects against damage to the inner ear following transient ischemia. ..
  7. Tauber S, Schorn K, Beyer W, Baumgartner R. Transmeatal cochlear laser (TCL) treatment of cochlear dysfunction: a feasibility study for chronic tinnitus. Lasers Med Sci. 2003;18:154-61 pubmed
    ..Further investigations by large double-blind placebo-controlled studies are mandatory for clinical evaluation of the presented TCL-system and its therapeutic effectiveness in acute and chronic cochlear dysfunction. ..
  8. Kim Y, Jun B, Yun S, Chang K. Intracochlear schwannoma extending to vestibule. Auris Nasus Larynx. 2013;40:497-9 pubmed publisher
    ..We report a case of intravestibulocochlear schwannoma causing vertigo that developed from an intracochlear tumor during MRI. We successfully removed the tumor via the transotic approach. ..
  9. Wang Y, Hirose K, Liberman M. Dynamics of noise-induced cellular injury and repair in the mouse cochlea. J Assoc Res Otolaryngol. 2002;3:248-68 pubmed
    ..Insights into mechanisms of acute and chronic noise-induced cellular damage are discussed. ..

More Information

Publications114 found, 100 shown here

  1. Keck T, Bürner H, Rettinger G. Prospective clinical study on cochlear function after erbium:yttrium-aluminum-garnet laser stapedotomy. Laryngoscope. 2005;115:1627-31 pubmed
    ..The Er:YAG laser stapedotomy in otosclerosis is a safe technique. Vestibular and cochlear function is not significantly disturbed after Er:YAG laser stapedotomy. ..
  2. Kanzaki S, Beyer L, Swiderski D, Izumikawa M, Stover T, Kawamoto K, et al. p27(Kip1) deficiency causes organ of Corti pathology and hearing loss. Hear Res. 2006;214:28-36 pubmed
    ..Manipulations to regulate the time and place of p27 inhibition will be necessary for inducing functionally useful hair cell regeneration. ..
  3. Ibrahim H, Kamel T, Abdel Salam N, Abu Ata S. Study of auditory function in children with chronic lung diseases. Int J Pediatr Otorhinolaryngol. 2011;75:39-42 pubmed publisher
    ..Children with chronic lung diseases are liable to cochlear dysfunction due to prolonged hypoxia. Inhaled aminoglycosides in chronic lung diseases is relatively safe on auditory functions. ..
  4. Develioglu O, Yilmaz M, Caglar E, Topak M, Kulekci M. Oto-toxic effect of gastric reflux. J Craniofac Surg. 2013;24:640-4 pubmed publisher
    ..This is the first study on the ototoxicity of acidified gastric pepsin. Our results demonstrate that acidified gastric pepsin causes hearing loss due to inner ear ototoxicity in a rat animal model. ..
  5. Magliulo G, Petti R, Vingolo G, Ronzoni R. [Experimental perilymphatic fistula: the electrocochleographic findings]. Acta Otorhinolaryngol Ital. 1992;12:547-52 pubmed
    ..This latter observation associated with a decrease in the amplitude of the threshold seems to be a specific audiologic sign of the fistula. The clinical implication are discussed...
  6. Janssen T. A review of the effectiveness of otoacoustic emissions for evaluating hearing status after newborn screening. Otol Neurotol. 2013;34:1058-63 pubmed publisher
    ..DPOAE audiograms provide a tool for a fast automated frequency-specific and quantitative evaluation of a mild or moderate hearing in follow-up diagnosis. ..
  7. Weegerink N, Swinnen F, Vanakker O, Casselman J, Dhooge I. Phenotype of a Belgian Family With 6p25 Deletion Syndrome. Ann Otol Rhinol Laryngol. 2016;125:734-45 pubmed publisher
    ..However, our findings can facilitate counseling of hearing impairment caused by 6p25 deletions. ..
  8. Willott J, Milbrandt J, Bross L, Caspary D. Glycine immunoreactivity and receptor binding in the cochlear nucleus of C57BL/6J and CBA/CaJ mice: effects of cochlear impairment and aging. J Comp Neurol. 1997;385:405-14 pubmed
    ..The data suggest that the combination of severe hearing loss and old age results in deficits in one or more inhibitory glycinergic circuits in the CN. ..
  9. Kimura H, Aso S, Watanabe Y. Prediction of progression from atypical to definite Ménière's disease using electrocochleography and glycerol and furosemide tests. Acta Otolaryngol. 2003;123:388-95 pubmed
    ..To investigate whether electrocochleography (ECochG) and glycerol and furosemide tests could predict progression from atypical to definite Ménière's disease (MD)...
  10. Incesulu A, Kocaturk S, Keyik B, Cakmakci E, Erkam U, Hekimoglu B. [A comparison between findings of high resolution computed tomography and magnetic resonance imaging in the preoperative assessment of cochlear implant patients]. Kulak Burun Bogaz Ihtis Derg. 2003;10:98-104 pubmed
    ..5%) by MRI, and in none by HRCT scans. Although HRCT provides valuable information for surgical planning, its limitations may justify the additional use of MRI before cochlear implantation. ..
  11. Torre P, Cruickshanks K, Klein B, Klein R, Nondahl D. The association between cardiovascular disease and cochlear function in older adults. J Speech Lang Hear Res. 2005;48:473-81 pubmed
    ..98, 95% CI = 0.61-1.58). Additionally, no other CVD variables were associated with cochlear impairment. This study provides data on a possible sex-specific association between CVD and DPOAEs in older adults. ..
  12. Tucci M, Quatraro C, Silvestris F. Sjögren's syndrome: an autoimmune disorder with otolaryngological involvement. Acta Otorhinolaryngol Ital. 2005;25:139-44 pubmed
    ..Here we review recent advances on the pathodgenesis of SS with a particular focus to otolaryngological manifestations. ..
  13. Nomiya R, Nomiya S, Kariya S, Okano M, Morita N, Cureoglu S, et al. Generalized arteriosclerosis and changes of the cochlea in young adults. Otol Neurotol. 2008;29:1193-7 pubmed publisher
    ..Degeneration of the cochlea, especially in the basal turn, was already apparent in young adults with generalized arteriosclerosis. ..
  14. Rampelberg O, Gerard J, Namias B, Gerard M. ENT manifestations of relapsing polychondritis. Acta Otorhinolaryngol Belg. 1997;51:73-7 pubmed
    ..The diagnosis is based on the evocative clinical picture and on histological confirmation. Treatment consists of corticosteroids and immunosuppressive agents. ..
  15. Shepherd R, Hardie N, Baxi J. Electrical stimulation of the auditory nerve: single neuron strength-duration functions in deafened animals. Ann Biomed Eng. 2001;29:195-201 pubmed
    ..These changes in the site of action potential generation have implications for the delivery of charge to ANFs via cochlear implants. ..
  16. Colletti V, Carner M, Miorelli V, Guida M, Colletti L, Fiorino F. Cochlear implant failure: is an auditory brainstem implant the answer?. Acta Otolaryngol. 2004;124:353-7 pubmed
    ..The two children who had achieved no hearing ability with their CI were able to detect sounds and words as early as 3 months after activation of the ABI. CI failure as a result of anatomical abnormalities can be remedied by an ABI. ..
  17. Thakur J, Mohindroo N, Sharma D, Soni K, Kaushal S. Evoked response audiometry in scrub typhus: prospective, randomised, case-control study. J Laryngol Otol. 2011;125:567-71 pubmed publisher
    ..To investigate the hypothesis of cochlear and retrocochlear damage in scrub typhus, using evoked response audiometry...
  18. Krause E, Mayerhofer A, Gurkov R, Drexl M, Braun T, Olzowy B, et al. Effects of acoustic stimuli used for vestibular evoked myogenic potential studies on the cochlear function. Otol Neurotol. 2013;34:1186-92 pubmed publisher
    ..Subjective auditory symptoms were reversible within 24 hours. Nevertheless, the stimulus levels and the number of repetitions should be kept as low as possible. ..
  19. Lin P, Hsu C, Lin Y, Lin Y, Lee H, Wu C, et al. Etiologic and Audiologic Characteristics of Patients With Pediatric-Onset Unilateral and Asymmetric Sensorineural Hearing Loss. JAMA Otolaryngol Head Neck Surg. 2017;143:912-919 pubmed publisher
    ..Pediatric-onset unilateral and asymmetric sensorineural hearing loss (SNHL) is a common condition, but in most patients, the cause remains unclear; thus, determination of the hearing outlook is difficult...
  20. Böhmer A. On the pathomechanism of cochlear dysfunction in experimental perilymph fistulas. Laryngoscope. 1991;101:1307-12 pubmed
  21. Eshraghi A, Telischi F, Hodges A, Odabasi O, Balkany T. Changes in programming over time in postmeningitis cochlear implant users. Otolaryngol Head Neck Surg. 2004;131:885-9 pubmed
    ..These patients need close follow-up of stimulation levels and programming modes postoperatively in order to perform optimally with CIs. B-3. ..
  22. Bodet E, Martinez V, Romeu C. [Cochlear involvement in acute otitis media]. Acta Otorrinolaringol Esp. 2005;56:396-9 pubmed
    ..In acute otitis media, the loss of ciIliated cells are mainly in the basal turn of the mice is cochlea, and affects the middle turn when the infection is repeated. ..
  23. Moore B, Vinay -. Amplitude modulation detection by listeners with unilateral dead regions. J Am Acad Audiol. 2009;20:597-606 pubmed
    ..The results have implications for the ability of people with dead regions to use information from frequency components falling inside the dead region. ..
  24. Prisman E, Ramsden J, Blaser S, Papsin B. Traumatic perilymphatic fistula with pneumolabyrinth: diagnosis and management. Laryngoscope. 2011;121:856-9 pubmed publisher
    ..We suggest exploration be reserved for patients with persisting cerebrospinal fluid leakage, progressive sensorineural hearing loss, or vestibular symptomatology...
  25. Musazzi U, Franzé S, Cilurzo F. Innovative pharmaceutical approaches for the management of inner ear disorders. Drug Deliv Transl Res. 2018;8:436-449 pubmed publisher
    ..In clinical practice, the current pharmacological approaches to treat cochlear diseases are based on the almost exclusive use of systemic steroids...
  26. Riera Sala C, Molina Mira A, Marco Algarra J, Martinez Soriano F, Olucha F. Inner ear lesion alters acoustically induced c-Fos expression in the rat auditory rhomboencephalic brainstem. Hear Res. 2001;162:53-66 pubmed
    ..We have found that unilateral inner ear lesions lead to bilateral impairment of the capability of acoustic pathway neurons, to being c-Fos-activated following sound stimulation. ..
  27. Stavroulaki P, Vossinakis I, Dinopoulou D, Doudounakis S, Adamopoulos G, Apostolopoulos N. Otoacoustic emissions for monitoring aminoglycoside-induced ototoxicity in children with cystic fibrosis. Arch Otolaryngol Head Neck Surg. 2002;128:150-5 pubmed
    ..They should be used for monitoring patients receiving ototoxic factors such as aminoglycosides. ..
  28. Yucel E, Erdil A, Keles N, Solmaz M, Deger K. [Evaluation of hearing performance in cochlear implant patients]. Kulak Burun Bogaz Ihtis Derg. 2002;9:342-5 pubmed
    ..9 versus 84.1, p=0.001). Early diagnosis and rehabilitation are essential to achieve better performance following cochlear implantation. ..
  29. Kaiser C, Girod D, Durham D. Breed-dependent susceptibility to acute sound exposure in young chickens. Hear Res. 2005;203:101-11 pubmed
    ..Our findings conflict with those reported by Durham et al. (2002). Our results identify a breed-dependent difference in susceptibility to acute sound exposure, with young egg layers displaying increased sensitivity. ..
  30. Maudonnet E, de Oliveira J, Rossato M, Hyppolito M. Gentamicin attenuates gentamicin-induced ototoxicity - self-protection. Drug Chem Toxicol. 2008;31:11-25 pubmed
    ..These results demonstrate that there was a considerable self-protection phenomenon by gentamicin. ..
  31. Ruiz A, Friedland D, Niparko J. Radiology quiz case 2. Cochlear otosclerosis. Arch Otolaryngol Head Neck Surg. 2002;128:1214, 1216-7 pubmed
  32. Jabłonka A. [Assessment of the glycerol test expanded by otoacoustic emissions in vestibulo-cochlear syndrome]. Otolaryngol Pol. 2005;59:953-5 pubmed
  33. Pasanisi E, Bacciu A, Vincenti V, Guida M, Barbot A, Berghenti M, et al. [Multi-channel cochlear implant in cochlear ossification]. Acta Otorhinolaryngol Ital. 2002;22:127-34 pubmed
  34. Wang J, Ding D, Salvi R. Carboplatin-induced early cochlear lesion in chinchillas. Hear Res. 2003;181:65-72 pubmed
    ..The large fluctuations in SDR and DDR that occur several hours after carboplatin treatment are most likely due to the neurotoxic effects of carboplatin. ..
  35. Tominaga M, Yamamoto H, Sone M, Teranishi M, Nakashima T. Response of cochlear blood flow to prostaglandin E1 applied topically to the round window. Acta Otolaryngol. 2006;126:232-6 pubmed
    ..The CBF response to PGE1 administration was similar before and after occlusion of the stapedial artery. ..
  36. Lee H, Kim H, Koo J, Kim J. Progression of acute cochleovestibulopathy into anterior inferior cerebellar artery infarction. J Neurol Sci. 2009;278:119-22 pubmed publisher
    ..AICA infarction should be considered in acute audiovestibular syndrome, especially in aged patients with vascular risk factors, even though the classic brainstem or cerebellar signs are absent...
  37. van Wolfswinkel M, Lahri H, Wismans P, Petit P, van Genderen P. Early small bowel perforation and cochleovestibular impairment as rare complications of typhoid fever. Travel Med Infect Dis. 2009;7:265-8 pubmed publisher
    ..The clinical features of typhoid fever are heterogeneous and rare complications may occur. The emergence of multidrug and nalidixic acid resistance may complicate further the treatment of this serious systemic infection. ..
  38. Sennaroglu L, Colletti V, Manrique M, Laszig R, Offeciers E, Saeed S, et al. Auditory brainstem implantation in children and non-neurofibromatosis type 2 patients: a consensus statement. Otol Neurotol. 2011;32:187-91 pubmed publisher
  39. Zaghis A, Todini L, Capaccio P, Grillo della Berta L, Pignataro L. Ossified versus patent cochlea: objective and subjective results of partial drill-out of the basal turn. J Otolaryngol. 2003;32:160-7 pubmed
    ..Together with the improvement in auditory and communicative skills, a better QOL (psychological and social comfort) is undoubtedly one of the more appreciated aspects for implanted patients. ..
  40. Franco Vidal V, Songu M, Blanchet H, Barreau X, Darrouzet V. Intracochlear hemorrhage after gamma knife radiosurgery. Otol Neurotol. 2007;28:240-4 pubmed
    ..To our knowledge, this is the first report of acute intracochlear hemorrhage after GKRS for VS. ..
  41. Aazh H, Moore B. Dead regions in the cochlea at 4 kHz in elderly adults: relation to absolute threshold, steepness of audiogram, and pure-tone average. J Am Acad Audiol. 2007;18:97-106 pubmed
    ..However, the mean absolute threshold at 4 kHz was significantly higher for the group with DRs than for the group without DRs. The prevalence of DRs exceeded 50% for hearing losses greater than 70 dB. ..
  42. Foster P. Autologous intratympanic blood patch for presumed perilymphatic fistulas. J Laryngol Otol. 2016;130:1158-1161 pubmed
    ..To assess an alternative to bed rest and surgery for suspected perilymphatic fistulas using intratympanic blood injections...
  43. Praetorius M, Staecker H. [ASA and the inner ear. An old acquaintance in a new light]. HNO. 2006;54:667-9 pubmed
  44. Wakabayashi K, Fujioka M, Kanzaki S, Okano H, Shibata S, Yamashita D, et al. Blockade of interleukin-6 signaling suppressed cochlear inflammatory response and improved hearing impairment in noise-damaged mice cochlea. Neurosci Res. 2010;66:345-52 pubmed publisher
    ..Anti-inflammatory cytokine therapy including IL-6 blockade would be a feasible novel therapeutic strategy for acute sensory neural hearing loss. ..
  45. Gleeson T, Lacy P, Bresnihan M, Gaffney R, Brennan P, Viani L. High resolution computed tomography and magnetic resonance imaging in the pre-operative assessment of cochlear implant patients. J Laryngol Otol. 2003;117:692-5 pubmed
    ..In this series the combination of CT and MRI has not been shown to be superior to either modality used alone, although anecdotal evidence to the contrary was noted...
  46. Donadieu E, Hamdi W, Deveze A, Lucciano M, Lavieille J, Magnan J, et al. Improved cryosections and specific immunohistochemical methods for detecting hypoxia in mouse and rat cochleae. Acta Histochem. 2007;109:177-84 pubmed
  47. Durisin M, Bartling S, Arnoldner C, Ende M, Prokein J, Lesinski Schiedat A, et al. Cochlear osteoneogenesis after meningitis in cochlear implant patients: a retrospective analysis. Otol Neurotol. 2010;31:1072-8 pubmed
    ..Retrospective clinical study...
  48. Richter C, Rajguru S, Matic A, Moreno E, Fishman A, Robinson A, et al. Spread of cochlear excitation during stimulation with pulsed infrared radiation: inferior colliculus measurements. J Neural Eng. 2011;8:056006 pubmed publisher
    ..The majority of ICC STCs indicated that the spread of activation evoked by optical stimuli is comparable to that produced by acoustic tone pips. ..
  49. Lam W, Hui Y, Au D, Chow L, Chan F, Yu L, et al. [Radiological study of temporal bone in children with profound deafness before cochlear implant: CT vs magnetic resonance imaging]. Zhonghua Er Bi Yan Hou Ke Za Zhi. 2002;37:440-2 pubmed
    ..To evaluate the clinical application of magnetic resonance imaging (MRI) and CT in children with profound deafness before cochlear implant and their impact on surgical decision...
  50. Ladrech S, Guitton M, Saido T, Lenoir M. Calpain activity in the amikacin-damaged rat cochlea. J Comp Neurol. 2004;477:149-60 pubmed
    ..By contrast, in these ganglion neurons PKCgamma may be implicated in a survival process. Finally, we suggest that calpain is involved in the remodeling of Deiters cells during the scarring process that follows hair cell loss...
  51. Choi J, Song M, Jeon J, Lee W, Chang J. Early surgical results of auditory brainstem implantation in nontumor patients. Laryngoscope. 2011;121:2610-8 pubmed publisher
    ..We herein describe the surgical results and auditory outcomes of ABI in nontumor patients...
  52. Bento R, Goffi Gomez M, Tsuji R, Fonseca A, Ikari L, Brito Neto R. Speech perception performance of double array multichannel cochlear implant users with standard and duplicated maps in each of the arrays. Otol Neurotol. 2013;34:245-50 pubmed
    ..The present investigation evaluated the speech perception performance of patients with ossified cochlea implanted with the 24M Double Array cochlear implant, using standard and duplicated maps in each of the arrays...
  53. Kraft S, Hsu C, Brough D, Staecker H. Atoh1 induces auditory hair cell recovery in mice after ototoxic injury. Laryngoscope. 2013;123:992-9 pubmed publisher
    ..To evaluate the ability of the Ad28.gfap.atoh1 to promote hair cell regeneration and hearing recovery in cochlea injured with kanamycin and furosemide...
  54. Ho S, Wiet R, Richter C. Modifying cochlear implant design: advantages of placing a return electrode in the modiolus. Otol Neurotol. 2004;25:497-503 pubmed
    ..A modiolar return electrode significantly increases the current flow across spiral ganglion cells into the modiolus, and may decrease the cochlear implant's power requirements...
  55. Morizane I, Hakuba N, Shimizu Y, Shinomori Y, Fujita K, Yoshida T, et al. Transient cochlear ischemia and its effects on the stria vascularis. Neuroreport. 2005;16:799-802 pubmed
    ..The results indicate that transient ischemia causes a reversible functional disorder of the stria vascularis with fine structural changes, which may be owing to dysfunction of Na+/K+-pump or gap junctions...
  56. Arnoldner C, Baumgartner W, Gstoettner W, Hamzavi J. Surgical considerations in cochlear implantation in children and adults: a review of 342 cases in Vienna. Acta Otolaryngol. 2005;125:228-34 pubmed
    ..Nevertheless, patients should be informed about possible problems and especially about the risk of a reoperation due to device failure...
  57. Modugno G, Magnani G, Brandolini C, Savastio G, Pirodda A. Could vestibular evoked myogenic potentials (VEMPs) also be useful in the diagnosis of perilymphatic fistula?. Eur Arch Otorhinolaryngol. 2006;263:552-5 pubmed
  58. Don M, Kwong B, Tanaka C. A diagnostic test for Ménière's Disease and Cochlear Hydrops: impaired high-pass noise masking of auditory brainstem responses. Otol Neurotol. 2005;26:711-22 pubmed
    ..Endolymphatic hydrops in patients diagnosed with Ménière's disease causes changes in the response properties of the basilar membrane that lead to impaired high-pass noise masking of auditory brainstem responses to clicks...
  59. Sanna M, Khrais T, Guida M, Falcioni M. Auditory brainstem implant in a child with severely ossified cochlea. Laryngoscope. 2006;116:1700-3 pubmed
    ..The aim of our study is to present a case where brainstem implantation was successfully performed as an alternative to cochlear implantation in a child with bilateral severe ossification of the cochlea...
  60. Yoshida T, Hakuba N, Morizane I, Fujita K, Cao F, Zhu P, et al. Hematopoietic stem cells prevent hair cell death after transient cochlear ischemia through paracrine effects. Neuroscience. 2007;145:923-30 pubmed
    ..Thus, we propose HSCs as a potential new therapeutic strategy for hearing loss...
  61. Roosli C, Linthicum F, Cureoglu S, Merchant S. Dysfunction of the cochlea contributing to hearing loss in acoustic neuromas: an underappreciated entity. Otol Neurotol. 2012;33:473-80 pubmed publisher
    ..Our goal was to perform a detailed assessment of cochlear pathology in patients with vestibular schwannoma (VS)...
  62. Nagura M, Iwasaki S, Mizuta K, Mineta H, Umemura K, Hoshino T. Role of nitric oxide in focal microcirculation disorder of guinea pig cochlea. Hear Res. 2001;153:7-13 pubmed
    ..01) 15 min after microcirculation disorder. These findings suggest that formation of endogenous NO plays a key role in the maintenance of CBF in acute focal cochlear microcirculation disorder...
  63. Freeman S, Priner R, Elidan J, Sohmer H. Objective method for differentiating between drug-induced vestibulotoxicity and cochleotoxicity. Otol Neurotol. 2001;22:70-5 pubmed
    ..An objective direct method is proposed to differentiate between drug-induced functional vestibulotoxicity and cochleotoxicity...
  64. Calmels M, Deguine O. Perilymphatic fistula. Ear Nose Throat J. 2004;83:666 pubmed
  65. Malinvaud D, Avan P, Germain D, Benistan K, Bonfils P. [The cochlea in Fabry disease: a sensorineural hearing loss model of vascular origin?]. Rev Med Interne. 2006;27:527-31 pubmed
    ..The enzyme defect leads to the systemic accumulation of neutral glycosphingolipids in tissues, mainly in the vascular endothelium...
  66. Ishikawa T, Kawamata T, Kawashima A, Yamaguchi K, Kubo O, Hori T, et al. Meningioma of the internal auditory canal with rapidly progressive hearing loss: case report. Neurol Med Chir (Tokyo). 2011;51:233-5 pubmed
    ..Common symptoms of IAC meningiomas are tinnitus and hearing loss, but rapidly progressive hearing loss is very rare. IAC meningioma is rare but should be taken into consideration as a cause of rapidly progressive hearing loss...
  67. Al Noury K. Distortion product otoacoustic emission for the screening of cochlear damage in children treated with cisplatin. Laryngoscope. 2011;121:1081-4 pubmed publisher
    ..To detect subtle hearing changes by measuring otoacoustic emissions in patients treated with a first dose of cisplatin...
  68. Goffi Gomez M, Magalhães A, Brito Neto R, Tsuji R, Gomes M, Bento R. Auditory brainstem implant outcomes and MAP parameters: report of experiences in adults and children. Int J Pediatr Otorhinolaryngol. 2012;76:257-64 pubmed publisher
    ..Although the results has been extensively reported, the stimulation parameters involved behind the outcomes have received less attention...
  69. Wu R, Hoshino T. Changes in off-lesion endocochlear potential following localized lesion in the lateral wall. Acta Otolaryngol. 1999;119:550-4 pubmed
    ..001). Conversely, no significant change was measured at any site located basal to the lesion. These findings suggest that the decrease in EP assumes the form of a gradient from the lower to upper turns in the guinea pig cochlea...
  70. Sugahara K, Shimogori H, Yamashita H. The role of acidic fibroblast growth factor in recovery of acoustic trauma. Neuroreport. 2001;12:3299-302 pubmed
    ..Cochlear function in aFGF treated ears recovered more quickly than that in control ears. These results suggest that aFGF may play an important role in cochlear recovery after acoustic injury...
  71. Radomskij P, Schmidt M, Heron C, Prasher D. Effect of MRI noise on cochlear function. Lancet. 2002;359:1485 pubmed
    ..The change in OAEs shows a clear effect of MRI noise on cochlear function, despite use of earplugs. The importance of correctly fitted earplugs cannot be underestimated...
  72. Nait Ali A, Siarry P. Application of simulated annealing for estimating BAEPs in endocochlear pathologies. Med Eng Phys. 2002;24:385-92 pubmed
    ..As an illustration, results based on real signals recorded from two patients are presented and discussed at the end of the paper...
  73. Zhong Z, Li X, Wu H. [Intra-arterial thrombolysis for the treatment of restricted cochlear microcirculation disorder in guinea pigs]. Zhonghua Er Bi Yan Hou Ke Za Zhi. 2003;38:24-8 pubmed
    ..To ascertain a new treatment method for restricted cochlear microcirculation disorder...
  74. Brookler K. Questioning the relationship between cochlear otosclerosis and sensorineural hearing loss. Laryngoscope. 2005;115:757; author reply 757-8 pubmed
  75. Okamoto Y, Hoya N, Kamiya K, Fujii M, Ogawa K, Matsunaga T. Permanent threshold shift caused by acute cochlear mitochondrial dysfunction is primarily mediated by degeneration of the lateral wall of the cochlea. Audiol Neurootol. 2005;10:220-33 pubmed
  76. Addison J, Kim H, Richter C. Cochlear preservation after meningitis: an animal model confirmation of adjunctive steroid therapy. Laryngoscope. 2006;116:279-82 pubmed
    ..The objective of the present study was to determine whether treating pneumococcal meningitis with a combined antibiotic and steroid regime will prevent cochlear damage, a common pneumococcal meningitis side effect...
  77. Nagy I, Fuchs S, Monge A, Huber A, Bodmer D. [Transplantation of neural stem cells into the cochlea]. HNO. 2007;55:862-70 pubmed
    ..In the presented study, our aim was to gain insight into how neuronal stem cells behave when they are transplanted, both in vitro and in vivo, into a damaged inner ear...
  78. Esparza C, Jauregui Renaud K, Morelos C, Muhl G, Mendez M, Carillo N, et al. Systemic high blood pressure and inner ear dysfunction: a preliminary study. Clin Otolaryngol. 2007;32:173-8 pubmed
    ..To assess the association between inner ear dysfunction and retinal vascular changes related to systemic arterial hypertension...
  79. Nevado J, Sanz R, Sánchez Rodríguez C, García Berrocal J, Martín Sanz E, González García J, et al. Ginkgo biloba extract (EGb761) protects against aging-related caspase-mediated apoptosis in rat cochlea. Acta Otolaryngol. 2010;130:1101-12 pubmed publisher
    ..EGb761 treatment has a significant benefit with an early and preventive effect, reversing the deleterious effect of aging in the integrity of the rat cochlea, even in the late stage of the rat lifespan...
  80. Millen S, Schnurr C, Schnurr B. Vestibular migraine: perspectives of otology versus neurology. Otol Neurotol. 2011;32:330-7 pubmed publisher
    ..To compare the attitudes and opinions of otologists and neurologists regarding the cause, diagnosis, and management of vestibular migraine...
  81. Ishimoto S, Kawamoto K, Stover T, Kanzaki S, Yamasoba T, Raphael Y. A glucocorticoid reduces adverse effects of adenovirus vectors in the cochlea. Audiol Neurootol. 2003;8:70-9 pubmed
    ..These data demonstrate that immunosuppressive treatment can reduce the negative consequences of repeated adenovirus-mediated gene therapy...
  82. Halpin C, Owen G, Gutiérrez Espeleta G, Sims K, Rehm H. Audiologic features of Norrie disease. Ann Otol Rhinol Laryngol. 2005;114:533-8 pubmed
    ..The objective of this study was to characterize the audiologic phenotype of Norrie disease for comparison with the pathophysiologic mechanism...
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    ..The aim of this prospective longitudinal study is to research the amplitude of distortion product otoacoustic emissions caused by the ototoxic drugs used, between the end of the administration and from 15 to 40 days after its use...
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    ..Jagged1 is also expressed in support cells in the adult ear and is not affected by drug damage. Sox2 and Jagged1 may be involved in the maintenance of support cells in adult mouse inner ear...
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    ..These findings showed that local rhIGF1 application using a hydrogel has the potential to protect the cochleae from ischemic injury...
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    ..On the basis of these results, we hypothesized that vasculitis of stria vascularis which generates endocochlear potential might cause these reversible cochlear-specific dysfunctions...
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    ..5 turns, which were found in the majority of our patients presenting with congenital PD. We investigated the hearing preservation rates and hearing outcomes of these patients after EAS cochlear implantation (EAS-CI)...
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    ..After comparing morphologic changes of the membranous labyrinth following use of each method, we concluded that perilymph suctioning from the round window can be used as an animal model of perilymphatic fistula...
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    ..Therefore, EOE may be used in screening and follow-up of high risk populations such as noise-exposed subjects...
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    ..These results demonstrate that lack of IGF-1 in mice severely affects postnatal survival, differentiation, and maturation of the cochlear ganglion cells and causes abnormal innervation of the sensory cells in the organ of Corti...