presbycusis

Summary

Summary: Gradual bilateral hearing loss associated with aging that is due to progressive degeneration of cochlear structures and central auditory pathways. Hearing loss usually begins with the high frequencies then progresses to sounds of middle and low frequencies.

Top Publications

  1. Nelson E, Hinojosa R. Presbycusis: a human temporal bone study of individuals with downward sloping audiometric patterns of hearing loss and review of the literature. Laryngoscope. 2006;116:1-12 pubmed
    ..of this retrospective case review was to identify patterns of cochlear element degeneration in individuals with presbycusis exhibiting downward sloping audiometric patterns of hearing loss and to correlate these findings with those ..
  2. Destefano A, Gates G, Heard Costa N, Myers R, Baldwin C. Genomewide linkage analysis to presbycusis in the Framingham Heart Study. Arch Otolaryngol Head Neck Surg. 2003;129:285-9 pubmed
    To identify chromosomal regions that show evidence of linkage to age-associated hearing impairment (presbycusis) in humans.
  3. Hoffman H, Dobie R, Ko C, Themann C, Murphy W. Hearing threshold levels at age 70 years (65-74 years) in the unscreened older adult population of the United States, 1959-1962 and 1999-2006. Ear Hear. 2012;33:437-40 pubmed publisher
    ..To provide hearing threshold percentiles from unscreened older adults for creating new Annex B reference standards...
  4. Park S, Back S, Choung Y, Kim H, Akil O, Lustig L, et al. ?-Synuclein deficiency and efferent nerve degeneration in the mouse cochlea: a possible cause of early-onset presbycusis. Neurosci Res. 2011;71:303-10 pubmed publisher
    ..that ?-synuclein deficiency and efferent auditory deficit might be a cause of hearing loss, we compared the morphology of efferent nerve endings and ?-synuclein expression within the cochleae of two mouse models of presbycusis.
  5. Iwai H, Lee S, Inaba M, Sugiura K, Baba S, Tomoda K, et al. Correlation between accelerated presbycusis and decreased immune functions. Exp Gerontol. 2003;38:319-25 pubmed
    The aim of the current study is to analyze the relationship between presbycusis and the immune system, which is affected by pathogenic environments, and to devise a strategy for the prevention of presbycusis using the SAMP1 mouse, an ..
  6. Helleman H, Jansen E, Dreschler W. Otoacoustic emissions in a hearing conservation program: general applicability in longitudinal monitoring and the relation to changes in pure-tone thresholds. Int J Audiol. 2010;49:410-9 pubmed publisher
    ..On group level, OAEs show a decline in a larger frequency region than the audiogram, suggesting an increased sensitivity of OAEs compared to audiometry...
  7. Ohlemiller K. Mechanisms and genes in human strial presbycusis from animal models. Brain Res. 2009;1277:70-83 pubmed publisher
    Schuknecht proposed a discrete form of presbycusis in which hearing loss results principally from degeneration of cochlear stria vascularis and decline of the endocochlear potential (EP)...
  8. Nelson E, Hinojosa R. Presbycusis: a human temporal bone study of individuals with flat audiometric patterns of hearing loss using a new method to quantify stria vascularis volume. Laryngoscope. 2003;113:1672-86 pubmed
    The purpose of this study was to determine the prevalence of stria vascularis atrophy in individuals with presbycusis and flat audiometric patterns of hearing loss...
  9. Demeester K, van Wieringen A, Hendrickx J, Topsakal V, Fransen E, Van Laer L, et al. Audiometric shape and presbycusis. Int J Audiol. 2009;48:222-32 pubmed publisher

More Information

Publications65

  1. Chang H, Chou P. Presbycusis among older Chinese people in Taipei, Taiwan: a community-based study. Int J Audiol. 2007;46:738-45 pubmed
    The purpose of this study was to estimate the prevalence and severity of presbycusis in older Chinese people in Taipei, Taiwan...
  2. Tremblay K, Ross B. Effects of age and age-related hearing loss on the brain. J Commun Disord. 2007;40:305-12 pubmed
    ..2) List three contributing factors for why older adults have difficult understanding speech in noise. (3) Give an example of a top-down approach to auditory rehabilitation...
  3. Angeli S, Bared A, Ouyang X, Du L, Yan D, Zhong Liu X. Audioprofiles and antioxidant enzyme genotypes in presbycusis. Laryngoscope. 2012;122:2539-42 pubmed publisher
    Audiometric patterns have been shown to indirectly provide information regarding the pathophysiology of presbycusis and be useful in the phenotyping of hereditary deafness.
  4. Humes L, Dubno J, Gordon Salant S, Lister J, Cacace A, Cruickshanks K, et al. Central presbycusis: a review and evaluation of the evidence. J Am Acad Audiol. 2012;23:635-66 pubmed publisher
    ..The authors reviewed 165 articles germane to central presbycusis. Of the 165 articles, 132 articles with a focus on human behavioral measures for either speech or nonspeech ..
  5. Gates G, Mills J. Presbycusis. Lancet. 2005;366:1111-20 pubmed
    The inevitable deterioration in hearing ability that occurs with age--presbycusis--is a multifactorial process that can vary in severity from mild to substantial...
  6. Spicer S, Schulte B. Pathologic changes of presbycusis begin in secondary processes and spread to primary processes of strial marginal cells. Hear Res. 2005;205:225-40 pubmed
    ..The reduced ATP level may cause cytotoxic alteration of the cytosolic Na(+)/K(+) ratio first in MC secondary processes and later in the primaries, with consequent degeneration of these structures...
  7. Markaryan A, Nelson E, Hinojosa R. Quantification of the mitochondrial DNA common deletion in presbycusis. Laryngoscope. 2009;119:1184-9 pubmed publisher
    This study was conducted to evaluate the association between the mitochondrial DNA (mtDNA) common deletion (CD) level in cochlear tissue and the severity of hearing loss in individuals with presbycusis.
  8. Bao J, Ohlemiller K. Age-related loss of spiral ganglion neurons. Hear Res. 2010;264:93-7 pubmed publisher
    ..With the advancement of recent genetic and pharmacologic tools, we should not only understand how SGNs die during aging, but also find ways to delay this loss...
  9. Syka J. The Fischer 344 rat as a model of presbycusis. Hear Res. 2010;264:70-8 pubmed publisher
    Due to the rising number of the aged human population all over the world, presbycusis is a phenomenon that deserves the increasing attention of the medical community as regards to prevention and treatment...
  10. Allen P, Eddins D. Presbycusis phenotypes form a heterogeneous continuum when ordered by degree and configuration of hearing loss. Hear Res. 2010;264:10-20 pubmed publisher
    ..Despite this, the prevalence of different patterns of hearing loss in presbycusis remains uncertain...
  11. Hartley D, Rochtchina E, Newall P, Golding M, Mitchell P. Use of hearing AIDS and assistive listening devices in an older Australian population. J Am Acad Audiol. 2010;21:642-53 pubmed publisher
  12. Pata Y, Akbas Y, Unal M, Duce M, Akbaş T, Micozkadioglu D. The relationship between presbycusis and mastoid pneumatization. Yonsei Med J. 2004;45:68-72 pubmed
    b>Presbycusis is defined as the natural hearing loss accompanying aging, caused by degenerative changes in the inner ear. The etiology of presbycusis is uncertain. However, it would appear that a complex genetic cause is most likely...
  13. Gratton M, VAZQUEZ A. Age-related hearing loss: current research. Curr Opin Otolaryngol Head Neck Surg. 2003;11:367-71 pubmed
    ..Age-related hearing loss affects the quality of life, not only of the elderly but also of their families and loved ones...
  14. Pichora Fuller M, Souza P. Effects of aging on auditory processing of speech. Int J Audiol. 2003;42 Suppl 2:2S11-6 pubmed
    ..The implications of age-related changes in auditory speech processing for future practice and research are discussed relative to interactions between older individuals and their acoustic environments...
  15. Wang J, Menchenton T, Yin S, Yu Z, Bance M, Morris D, et al. Over-expression of X-linked inhibitor of apoptosis protein slows presbycusis in C57BL/6J mice. Neurobiol Aging. 2010;31:1238-49 pubmed publisher
    Apoptosis of cochlear cells plays a significant role in age-related hearing loss or presbycusis. In this study, we evaluated whether over-expression of the anti-apoptotic protein known as X-linked Inhibitor of Apoptosis Protein (XIAP) ..
  16. Sha S, Kanicki A, Dootz G, Talaska A, Halsey K, Dolan D, et al. Age-related auditory pathology in the CBA/J mouse. Hear Res. 2008;243:87-94 pubmed publisher
    ..with a modest reduction of ganglion cell density and an unchanged endocochlear potential suggest sensorineural presbycusis. The superimposed early hearing loss at low frequencies, which is not seen in animals bred in-house, may ..
  17. Sziklai I, Szilvássy J, Szilvassy Z. Tinnitus control by dopamine agonist pramipexole in presbycusis patients: a randomized, placebo-controlled, double-blind study. Laryngoscope. 2011;121:888-93 pubmed publisher
    ..We hypothesized that pramipexole, an agonist on D2/D3 receptors, may antagonize tinnitus in the presbycusis patients (in the frequency range of 250 to 8,000 Hz) in a dose schedule accepted for the treatment of Parkinson'..
  18. Parham K, McKinnon B, Eibling D, Gates G. Challenges and opportunities in presbycusis. Otolaryngol Head Neck Surg. 2011;144:491-5 pubmed publisher
    ..In 2006, between 35% and 50% of those aged 65 years or older reportedly had presbycusis, a sensory impairment that contributes to social isolation and loss of autonomy and is associated with anxiety, ..
  19. Vasilyeva O, Frisina S, Zhu X, Walton J, Frisina R. Interactions of hearing loss and diabetes mellitus in the middle age CBA/CaJ mouse model of presbycusis. Hear Res. 2009;249:44-53 pubmed publisher
    ..On the other hand, initial results of effects from very high blood glucose level (T1DM) on the auditory midbrain showed disruption of central inhibition, increased response synchrony or enhanced excitation in the inferior colliculus...
  20. Fetoni A, Picciotti P, Paludetti G, Troiani D. Pathogenesis of presbycusis in animal models: a review. Exp Gerontol. 2011;46:413-25 pubmed publisher
    b>Presbycusis is the most common cause of hearing loss in aged subjects, reducing individual's communicative skills...
  21. Iwai H, Baba S, Omae M, Lee S, Yamashita T, Ikehara S. Maintenance of systemic immune functions prevents accelerated presbycusis. Brain Res. 2008;1208:8-16 pubmed publisher
    There is no effective therapy for progressive hearing loss such as presbycusis, the causes of which remain poorly understood because of the difficulty of separating genetic and environmental contributions...
  22. Li S, Wang D, Wang K, Hoffmann Kuhnt M, Fernando N, Taylor E, et al. Possible age-related hearing loss (presbycusis) and corresponding change in echolocation parameters in a stranded Indo-Pacific humpback dolphin. J Exp Biol. 2013;216:4144-53 pubmed publisher
    ..Considering that the older dolphin was ~40 years old, its lower high-frequency hearing range with lower click peak and centre frequencies could probably be explained by age-related hearing loss (presbycusis).
  23. Profant O, Balogová Z, Dezortova M, Wagnerova D, Hajek M, Syka J. Metabolic changes in the auditory cortex in presbycusis demonstrated by MR spectroscopy. Exp Gerontol. 2013;48:795-800 pubmed publisher
    In humans, aging is accompanied by the deterioration of the hearing function--presbycusis. The major etiology for presbycusis is the loss of hair cells in the inner ear; less well known are changes in the central auditory system...
  24. Willott J, Hnath Chisolm T, Lister J. Modulation of presbycusis: current status and future directions. Audiol Neurootol. 2001;6:231-49 pubmed
    Literature and ideas are reviewed concerning the modulation of presbycusis - the influence of variables that can alter the severity and/or time course of presbycusis or counteract its negative aspects...
  25. Ates N, Unal M, Tamer L, Derici E, Karakas S, Ercan B, et al. Glutathione S-transferase gene polymorphisms in presbycusis. Otol Neurotol. 2005;26:392-7 pubmed
    ..The etiology of presbycusis is much less certain; however, a complex genetic cause is most likely...
  26. Lee F, Matthews L, Dubno J, Mills J. Longitudinal study of pure-tone thresholds in older persons. Ear Hear. 2005;26:1-11 pubmed
    ..The objectives were to study longitudinal changes in thresholds as well as the effects of initial threshold levels, age, gender, and noise history on these longitudinal changes...
  27. Someya S, Yamasoba T, Weindruch R, Prolla T, Tanokura M. Caloric restriction suppresses apoptotic cell death in the mammalian cochlea and leads to prevention of presbycusis. Neurobiol Aging. 2007;28:1613-22 pubmed
    b>Presbycusis is characterized by an age-related progressive decline of auditory function, and arises mainly from the degeneration of hair cells or spiral ganglion (SG) cells in the cochlea...
  28. Oberg M, Marcusson J, Nagga K, Wressle E. Hearing difficulties, uptake, and outcomes of hearing aids in people 85 years of age. Int J Audiol. 2012;51:108-15 pubmed publisher
    ..The aim of this study was to investigate self-reported hearing difficulties, uptake, and hearing-aid outcomes and their relationships to demographic, cognitive, psychosocial, and health variables in 85 year olds...
  29. Fowler C, Torre P, Kemnitz J. Effects of caloric restriction and aging on the auditory function of rhesus monkeys (Macaca mulatta): The University of Wisconsin Study. Hear Res. 2002;169:24-35 pubmed
    ..The purpose of the present study was to document presbycusis and the effect of caloric restriction on presbycusis in monkeys...
  30. Cilento B, Norton S, Gates G. The effects of aging and hearing loss on distortion product otoacoustic emissions. Otolaryngol Head Neck Surg. 2003;129:382-9 pubmed
    ..Age changes in DPOE amplitude for frequencies of f2 from 1 to 8 kHz adjusted for pure-tone threshold level were assessed by multivariate linear regression...
  31. Guimaraes P, Zhu X, Cannon T, Kim S, Frisina R. Sex differences in distortion product otoacoustic emissions as a function of age in CBA mice. Hear Res. 2004;192:83-9 pubmed
    Age-related hearing loss--presbycusis--is the number one communication problem of the aged. A major contributor to presbycusis is the progressive degeneration of cochlear outer hair cells (OHCs)...
  32. Gates G. Central presbycusis: an emerging view. Otolaryngol Head Neck Surg. 2012;147:1-2 pubmed publisher
    Age-related dysfunction of the central auditory system (central presbycusis) is common but rarely looked for by those who provide aural rehabilitation...
  33. Zhang Q, Liu H, McGee J, Walsh E, Soukup G, He D. Identifying microRNAs involved in degeneration of the organ of corti during age-related hearing loss. PLoS ONE. 2013;8:e62786 pubmed publisher
  34. Unal M, Tamer L, Dogruer Z, Yildirim H, Vayisoglu Y, Camdeviren H. N-acetyltransferase 2 gene polymorphism and presbycusis. Laryngoscope. 2005;115:2238-41 pubmed
    ..The excessive amount of ROS generation occurs in the ageing inner ear. The exact etiopathogenesis of presbycusis is not known, but it is generally accepted that it is the result of series of insults, such as physiologic age-..
  35. Chen M, Webster P, Yang E, Linthicum F. Presbycusic neuritic degeneration within the osseous spiral lamina. Otol Neurotol. 2006;27:316-22 pubmed
    To describe a neglected anatomic variant occurring with presbycusis.
  36. Tadros S, D Souza M, Zhu X, Frisina R. Apoptosis-related genes change their expression with age and hearing loss in the mouse cochlea. Apoptosis. 2008;13:1303-21 pubmed publisher
    To understand possible causative roles of apoptosis gene regulation in age-related hearing loss (presbycusis), apoptotic gene expression patterns in the CBA mouse cochlea of four different age and hearing loss groups were compared, using ..
  37. Konrad Martin D, Dille M, McMillan G, Griest S, McDermott D, Fausti S, et al. Age-related changes in the auditory brainstem response. J Am Acad Audiol. 2012;23:18-35; quiz 74-5 pubmed publisher
    ..Results suggest that aging reduces the numbers and/or synchrony of contributing auditory nerve units. Results also support the concept that aging reduces the numbers, though perhaps not the synchrony, of central ABR generators. ..
  38. Prosen C, Dore D, May B. The functional age of hearing loss in a mouse model of presbycusis. I. Behavioral assessments. Hear Res. 2003;183:44-56 pubmed
    b>Presbycusis is a common form of hearing loss that progresses from high to low frequencies with advancing age...
  39. Ison J, Allen P. A diminished rate of "physiological decay" at noise offset contributes to age-related changes in temporal acuity in the CBA mouse model of presbycusis. J Acoust Soc Am. 2003;114:522-8 pubmed
    ..These data indicate that temporal acuity as measured by this gap detection method is limited in very old mice by their reduced ability to follow the abrupt change in noise level at the beginning of the gap...
  40. Huang Q, Tang J. Age-related hearing loss or presbycusis. Eur Arch Otorhinolaryngol. 2010;267:1179-91 pubmed publisher
    ..Although many adults retain good hearing as they aging, hearing loss related with age-presbycusis which can vary in severity from mild to substantial is common among elderly persons...
  41. Ohlemiller K, Gagnon P. Apical-to-basal gradients in age-related cochlear degeneration and their relationship to "primary" loss of cochlear neurons. J Comp Neurol. 2004;479:103-16 pubmed
    The predominant conceptual framework for understanding human age-related hearing loss (ARHL, or presbycusis) holds that three different cochlear elements (organ of Corti, afferent neurons, and stria vascularis) can degenerate ..
  42. Monzani D, Galeazzi G, Genovese E, Marrara A, Martini A. Psychological profile and social behaviour of working adults with mild or moderate hearing loss. Acta Otorhinolaryngol Ital. 2008;28:61-6 pubmed
  43. Bared A, Ouyang X, Angeli S, Du L, Hoang K, Yan D, et al. Antioxidant enzymes, presbycusis, and ethnic variability. Otolaryngol Head Neck Surg. 2010;143:263-8 pubmed publisher
    A proposed mechanism for presbycusis is a significant increase in oxidative stress in the cochlea. The enzymes glutathione S-transferase (GST) and N-acetyltransferase (NAT) are two classes of antioxidant enzymes active in the cochlea...
  44. Bovo R, Ciorba A, Martini A. Environmental and genetic factors in age-related hearing impairment. Aging Clin Exp Res. 2011;23:3-10 pubmed
    Age-related hearing impairment (ARHI), or presbycusis, is a complex disease with multifactorial etiology...
  45. Mazelova J, Popelar J, Syka J. Auditory function in presbycusis: peripheral vs. central changes. Exp Gerontol. 2003;38:87-94 pubmed
    ..The results support the view that presbycusis represents a combination of deteriorated function of the auditory periphery with deteriorated function of the ..
  46. Sousa C, Castro Júnior N, Larsson E, Ching T. Risk factors for presbycusis in a socio-economic middle-class sample. Braz J Otorhinolaryngol. 2009;75:530-6 pubmed
    b>Presbycusis, or the aging ear, involves mainly the inner ear and the cochlear nerve, causing sensorineural hearing loss. Risk factors include systemic diseases and poor habits that cause inner ear damage and lead to presbycusis...
  47. Johnson K, Erway L, Cook S, Willott J, Zheng Q. A major gene affecting age-related hearing loss in C57BL/6J mice. Hear Res. 1997;114:83-92 pubmed
    ..ABR test results and cochlear histopathology of aged progenitors of these congenic lines are presented. Ahl is the first gene causing late-onset, non-syndromic hearing loss that has been reported in the mouse...
  48. Fischel Ghodsian N, Bykhovskaya Y, Taylor K, Kahen T, Cantor R, Ehrenman K, et al. Temporal bone analysis of patients with presbycusis reveals high frequency of mitochondrial mutations. Hear Res. 1997;110:147-54 pubmed
    b>Presbycusis is a histologically and genetically heterogenous group of disorders, which lead to progressive, primarily sensorineural hearing loss with aging...
  49. Gates G, Couropmitree N, Myers R. Genetic associations in age-related hearing thresholds. Arch Otolaryngol Head Neck Surg. 1999;125:654-9 pubmed
    ..To determine the inheritance of age-related hearing loss...
  50. Frisina D, Frisina R. Speech recognition in noise and presbycusis: relations to possible neural mechanisms. Hear Res. 1997;106:95-104 pubmed
    This study is part of ongoing efforts to characterize and determine the neural bases of presbycusis. These efforts utilize humans and animals in sets of overlapping hypotheses and experiments...
  51. Sprinzl G, Riechelmann H. Current trends in treating hearing loss in elderly people: a review of the technology and treatment options - a mini-review. Gerontology. 2010;56:351-8 pubmed publisher
    ..An estimated 70-80% of adults between 65 and 75 years of age suffer from presbycusis, or age-related, bilateral sensorineural hearing loss (HL) in the high frequencies...
  52. Gates G, Gates G. The effect of noise on cochlear aging. Ear Hear. 2006;27:91; author reply 92 pubmed
  53. Zhang W, Zheng J, Meng J, Neng L, Chen X, Qin Z. Macrophage migration inhibitory factor knockdown inhibit viability and induce apoptosis of PVM/Ms. Mol Med Rep. 2017;16:8643-8648 pubmed publisher
    ..Thus, the results of the present study may provide a novel potential therapeutic approach and prevention method for presbycusis.
  54. Veras R, Mattos L. Audiology and aging: literature review and current horizons. Braz J Otorhinolaryngol. 2007;73:122-8 pubmed
    ..to review the literature on aging-related hearing loss and its current impacts...
  55. Ozimek E, Wicher A, Szyfter W, Szymiec E. Distortion product otoacoustic emission (DPOAE) in tinnitus patients. J Acoust Soc Am. 2006;119:527-38 pubmed
    ..The effect of age on the DPOAE level was clearly noted only for the tinnitus patients with clinically normal-hearing thresholds and was ambiguous for the tinnitus patients with hearing loss...
  56. Kaga K. [Presbycusis]. Nihon Ronen Igakkai Zasshi. 2004;41:505-6 pubmed