rubella virus

Summary

Summary: The type (and only) species of RUBIVIRUS causing acute infection in humans, primarily children and young adults. Humans are the only natural host. A live, attenuated vaccine is available for prophylaxis.

Top Publications

  1. ncbi Intrathecal polyspecific immune response to neurotropic viruses in multiple sclerosis: a comparative report from Cuban patients
    M Robinson-Agramonte
    Neuroimmunology Department, International Center for Neurological Restoration, Havana City, Cuba
    Acta Neurol Scand 115:312-8. 2007
  2. doi Status of global virologic surveillance for rubella viruses
    Emily S Abernathy
    Division of Viral Diseases, National Center for Immunizations and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Infect Dis 204:S524-32. 2011
  3. ncbi Microarray analyses of differentially expressed human genes and biological processes in ECV304 cells infected with rubella virus
    Xiao yang Mo
    Center for Heart Development, Key Lab of National Education Ministry, College of Life Sciences, Hunan Normal University, Changsha, Hunan, China
    J Med Virol 79:1783-91. 2007
  4. pmc Emergence and continuous evolution of genotype 1E rubella viruses in China
    Zhen Zhu
    State Key Laboratory for Molecular Virology and Genetic Engineering, National Institute for Viral Disease Control and Prevention, Beijing, People s Republic of China
    J Clin Microbiol 50:353-63. 2012
  5. pmc Rubella virus genotypes in the People's Republic of China between 1979 and 2007: a shift in endemic viruses during the 2001 Rubella Epidemic
    Zhen Zhu
    WHO WPRO Regional Reference Measles Rubella Laboratory and State Key Laboratory for Molecular Virology and Genetic Engineering, National Institute for Viral Disease Control and Prevention, Beijing, People s Republic of China
    J Clin Microbiol 48:1775-81. 2010
  6. doi Intraocular antibody synthesis against rubella virus and other microorganisms in Fuchs' heterochromic cyclitis
    Peter C Ruokonen
    Augenklinik Charité Universitätsmedizin Berlin CVK Germany, Augustenburger Platz 1, 13353 Berlin, Germany
    Graefes Arch Clin Exp Ophthalmol 248:565-71. 2010
  7. doi Rubella virus as a possible etiological agent of Fuchs heterochromic iridocyclitis
    Jun Suzuki
    Department of Ophthalmology, Tokyo Medical University Hospital, 6 7 1 Nishishinjuku, Shinjuku ku, Tokyo, 160 0023, Japan
    Graefes Arch Clin Exp Ophthalmol 248:1487-91. 2010
  8. ncbi Application of molecular and serological assays to case based investigations of rubella and congenital rubella syndrome
    Li Jin
    Virus Reference Department, Centre for Infections, Health Protection Agency, London, UK
    J Med Virol 79:1017-24. 2007
  9. doi Primary investigation of 31 infants with suspected congenital rubella syndrome in Sudan
    A Omer
    Commission for Biotechnology and Genetic Engineering National Centre for Research Ministry of Science and Technology, Health Protection Agency, London, UK
    Clin Microbiol Infect 16:678-82. 2010
  10. ncbi Co-circulation of multiple rubella virus strains in Belarus forming novel genetic groups within clade 1
    Judith M Hübschen
    Institute of Immunology and WHO Collaborative Centre for Measles and WHO European Regional Reference Laboratory for Measles and Rubella, Laboratoire National de Santé, 20A rue Auguste Lumière, L 1011 Luxembourg
    J Gen Virol 88:1960-6. 2007

Research Grants

  1. MOLECULAR BIOLOGY OF RUBELLA VIRUS
    TERYL FREY; Fiscal Year: 2006
  2. MOLECULAR BIOLOGY OF RUBELLA VIRUS
    TERYL FREY; Fiscal Year: 1993
  3. Immune Regulation of CNS Viral Recrudescence
    Cornelia Bergmann; Fiscal Year: 2007
  4. Immune Regulation of CNS Viral Recrudescence
    Cornelia Bergmann; Fiscal Year: 2010
  5. Immune Regulation of CNS Viral Recrudescence
    Cornelia Bergmann; Fiscal Year: 2009
  6. Prenatal Factors and Risk of Bipolar Disorder
    Alan Brown; Fiscal Year: 2007
  7. Prenatal Factors and Risk of Bipolar Disorder
    Alan Brown; Fiscal Year: 2009
  8. Prenatal Factors and Risk of Schizophrenia in a Finnish National Birth Cohort
    ALAN STEWART BROWN; Fiscal Year: 2010
  9. MOLECULAR BIOLOGY OF RUBELLA VIRUS
    TERYL FREY; Fiscal Year: 2000
  10. Prenatal Factors and Risk of Schizophrenia in a Finnish National Birth Cohort
    Alan Brown; Fiscal Year: 2009

Detail Information

Publications253 found, 100 shown here

  1. ncbi Intrathecal polyspecific immune response to neurotropic viruses in multiple sclerosis: a comparative report from Cuban patients
    M Robinson-Agramonte
    Neuroimmunology Department, International Center for Neurological Restoration, Havana City, Cuba
    Acta Neurol Scand 115:312-8. 2007
    ..Intrathecal measles(M)- rubella(R)- and varicella zoster(Z)-antibody synthesis in German and Cuban multiple sclerosis (MS) patients are compared considering the different rubella epidemiology in the tropics...
  2. doi Status of global virologic surveillance for rubella viruses
    Emily S Abernathy
    Division of Viral Diseases, National Center for Immunizations and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Infect Dis 204:S524-32. 2011
    ..Current challenges are discussed...
  3. ncbi Microarray analyses of differentially expressed human genes and biological processes in ECV304 cells infected with rubella virus
    Xiao yang Mo
    Center for Heart Development, Key Lab of National Education Ministry, College of Life Sciences, Hunan Normal University, Changsha, Hunan, China
    J Med Virol 79:1783-91. 2007
    ..Except for ZNF175, gene annotation indicated four of these genes encoded interferon or interferon-induced genes. These results suggest that genes relevant to interferon-regulated pathways may be involved in the pathogenesis of rubella...
  4. pmc Emergence and continuous evolution of genotype 1E rubella viruses in China
    Zhen Zhu
    State Key Laboratory for Molecular Virology and Genetic Engineering, National Institute for Viral Disease Control and Prevention, Beijing, People s Republic of China
    J Clin Microbiol 50:353-63. 2012
    ..and estimate the evolutionary rate, molecular clock phylogeny, and demographic history of the predominant rubella virus genotypes circulating in China using Bayesian Markov chain Monte Carlo phylodynamic analyses...
  5. pmc Rubella virus genotypes in the People's Republic of China between 1979 and 2007: a shift in endemic viruses during the 2001 Rubella Epidemic
    Zhen Zhu
    WHO WPRO Regional Reference Measles Rubella Laboratory and State Key Laboratory for Molecular Virology and Genetic Engineering, National Institute for Viral Disease Control and Prevention, Beijing, People s Republic of China
    J Clin Microbiol 48:1775-81. 2010
    ..The Chinese rubella virus sequences were categorized into 5 of the 13 rubella virus genotypes, 1a, 1E, 1F, 2A, and 2B; cocirculations of ..
  6. doi Intraocular antibody synthesis against rubella virus and other microorganisms in Fuchs' heterochromic cyclitis
    Peter C Ruokonen
    Augenklinik Charité Universitätsmedizin Berlin CVK Germany, Augustenburger Platz 1, 13353 Berlin, Germany
    Graefes Arch Clin Exp Ophthalmol 248:565-71. 2010
    Fuchs' heterochromic cyclitis (FHC) is a common intraocular disease of uncertain etiology that has recently been related to rubella virus (RV) infection.
  7. doi Rubella virus as a possible etiological agent of Fuchs heterochromic iridocyclitis
    Jun Suzuki
    Department of Ophthalmology, Tokyo Medical University Hospital, 6 7 1 Nishishinjuku, Shinjuku ku, Tokyo, 160 0023, Japan
    Graefes Arch Clin Exp Ophthalmol 248:1487-91. 2010
    To determine whether rubella virus is involved in the pathogenesis of Fuchs heterochromic iridocyclitis (FHI).
  8. ncbi Application of molecular and serological assays to case based investigations of rubella and congenital rubella syndrome
    Li Jin
    Virus Reference Department, Centre for Infections, Health Protection Agency, London, UK
    J Med Virol 79:1017-24. 2007
    ..In order to comply with recent WHO recommendations for establishing uniform genetic analysis protocols for rubella virus we have developed a new block based PCR assay (PCR-E317), which extends the sequence generated by the block ..
  9. doi Primary investigation of 31 infants with suspected congenital rubella syndrome in Sudan
    A Omer
    Commission for Biotechnology and Genetic Engineering National Centre for Research Ministry of Science and Technology, Health Protection Agency, London, UK
    Clin Microbiol Infect 16:678-82. 2010
    ..For the first time in Sudan, the rubella virus genome was directly detected in clinical specimens of six CRS cases and two viruses were isolated in cell ..
  10. ncbi Co-circulation of multiple rubella virus strains in Belarus forming novel genetic groups within clade 1
    Judith M Hübschen
    Institute of Immunology and WHO Collaborative Centre for Measles and WHO European Regional Reference Laboratory for Measles and Rubella, Laboratoire National de Santé, 20A rue Auguste Lumière, L 1011 Luxembourg
    J Gen Virol 88:1960-6. 2007
    ..a comprehensive genetic characterization, little is known about circulating strains and genotypes of rubella virus (RUBV) for many European countries...
  11. doi The intrathecal, polyspecific antiviral immune response: Specific for MS or a general marker of CNS autoimmunity?
    Sven Jarius
    Division of Molecular Neuroimmunology, Department of Neurology, Ruprecht Karl University, Heidelberg, Germany
    J Neurol Sci 280:98-100. 2009
    ..Besides MS and CNS vasculitis, paraneoplastic neurological disorders (PND) represent the best recognized models of CNS autoimmunity...
  12. pmc Comparison of four methods using throat swabs to confirm rubella virus infection
    Zhen Zhu
    National Institute for Viral Disease Control and Prevention, China CDC, Beijing, People s Republic of China
    J Clin Microbiol 45:2847-52. 2007
    Laboratory tests are essential for confirming sporadic cases and outbreaks of rubella. Detection of rubella virus is often necessary to confirm rubella cases and to identify specimens to be used to characterize wild-type rubella viruses...
  13. pmc Phylogenetic analysis of rubella viruses involved in congenital rubella infections in France between 1995 and 2009
    Christelle Vauloup-Fellous
    INSERM U764, Universite Paris Sud, AP HP, Microbiology Department, Hopital Antoine Beclere, Clamart, France
    J Clin Microbiol 48:2530-5. 2010
    ..The coding region of the rubella virus E1 gene was amplified directly from clinical specimens by reverse transcriptase PCR, and the resulting DNA ..
  14. ncbi Genomic analysis of diverse rubella virus genotypes
    Yumei Zhou
    Department of Biology, Georgia State University, Atlanta, GA, USA
    J Gen Virol 88:932-41. 2007
    Based on the sequence of the E1 glycoprotein gene, two clades and ten genotypes of Rubella virus have been distinguished; however, genomic sequences have been determined for viruses in only two of these genotypes...
  15. pmc Humoral immune response to primary rubella virus infection
    Kim M Wilson
    National Serology Reference Laboratory, St Vincent s Institute of Medical Research, Melbourne, Australia 3065
    Clin Vaccine Immunol 13:380-6. 2006
    An assay capable of distinguishing between the immune response generated by recent exposure to rubella virus and the immune response existing as a result of past exposure or immunization is required for the diagnosis of primary rubella ..
  16. ncbi Epidemiologic relationship between fuchs heterochromic iridocyclitis and the United States rubella vaccination program
    Andrea D Birnbaum
    University of Illinois at Chicago, Department of Ophthalmology and Visual Science, Chicago, Illinois 60612, USA
    Am J Ophthalmol 144:424-428. 2007
    ..To investigate an epidemiologic association between Fuchs heterochromic iridocyclitis (FHI) and the rubella vaccination program in the United States...
  17. ncbi An indirect immunocolorimetric assay to detect rubella virus infected cells
    Min hsin Chen
    National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Virol Methods 146:414-8. 2007
    An indirect immunocolorimetric assay (ICA) to detect rubella virus infected cells by the naked eye was developed...
  18. pmc Phosphorylation of rubella virus capsid regulates its RNA binding activity and virus replication
    Lok Man J Law
    Departments of Cell Biology Biochemistry Signal Transduction Research Group, University of Alberta, Edmonton, Alberta T6G 2H7, Canada
    J Virol 77:1764-71. 2003
    b>Rubella virus is an enveloped positive-strand RNA virus of the family TOGAVIRIDAE: Virions are composed of three structural proteins: a capsid and two membrane-spanning glycoproteins, E2 and E1...
  19. pmc Analysis of gene expression in fetal and adult cells infected with rubella virus
    Maria Pilar Adamo
    Laboratorio de Inmunologia, Instituto de Virologia JM Vanella, Facultad de Ciencias Medicas, Universidad Nacional de Cordoba, Cordoba, Argentina
    Virology 370:1-11. 2008
    Congenital infection with rubella virus (RUB) leads to persistent infection and congenital defects and we showed previously that primary human fetal fibroblasts did not undergo apoptosis when infected with RUB, which could promote fetal ..
  20. pmc Rubella virus replication and links to teratogenicity
    J Y Lee
    Research and Molecular Development Division, Victorian Infectious Diseases Reference Laboratory, North Melbourne, Victoria 3051, Australia
    Clin Microbiol Rev 13:571-87. 2000
    b>Rubella virus (RV) is the causative agent of the disease known more popularly as German measles. Rubella is predominantly a childhood disease and is endemic throughout the world...
  21. doi A multiplex TaqMan PCR assay for the detection of measles and rubella virus
    Judith M Hübschen
    Institute of Immunology and WHO Collaborative Centre for Measles and WHO European Regional Reference Laboratory for Measles and Rubella, Laboratoire National de Santé, 20A rue Auguste Lumière, L 1950 Luxembourg, Luxembourg
    J Virol Methods 149:246-50. 2008
    Measles and rubella virus cause fever/rash diseases that are difficult to differentiate clinically. Both viruses can be detected in the same clinical specimens and are propagated on the same cell cultures...
  22. ncbi The riddle of fuchs heterochromic uveitis
    Aniki Rothova
    Am J Ophthalmol 144:447-8. 2007
  23. ncbi Phylogenetic analysis of rubella virus isolated during a period of epidemic transmission in Italy, 1991-1997
    Du Ping Zheng
    Department of Biology, Georgia State University, Atlanta, Georgia 30303, USA
    J Infect Dis 187:1587-97. 2003
    To study the molecular epidemiology of rubella virus during endemic transmission, phylogenetic analysis of the nucleotide sequence of the E1 gene was done with 31 isolates collected in northern Italy during 1991-1997, a period spanning 3 ..
  24. ncbi Characterization of genotype II Rubella virus strains
    D P Zheng
    Department of Biology, Georgia State University, Atlanta, Georgia 30303, USA
    Arch Virol 148:1835-50. 2003
    Two genotypes of Rubella virus have been described that differ by 8-9% at the nucleotide level in the E1 glycoprotein gene...
  25. doi Analysis of base and codon usage by rubella virus
    Yumei Zhou
    Department of Biology, Georgia State University, Atlanta, GA 30303, USA
    Arch Virol 157:889-99. 2012
    b>Rubella virus (RUBV), a small, plus-strand RNA virus that is an important human pathogen, has the unique feature that the GC content of its genome (70%) is the highest (by 20%) among RNA viruses...
  26. pmc Characterization of rubella virus-specific antibody responses by using a new synthetic peptide-based enzyme-linked immunosorbent assay
    L A Mitchell
    Department of Pathology, Faculty of Medicine, University of British Columbia, Vancouver, Canada
    J Clin Microbiol 30:1841-7. 1992
    b>Rubella virus (RV)-specific immunoglobulin G antibodies were studied by enzyme-linked immunosorbent assay (ELISA) techniques in sera from RV (RA 27/3)-vaccinated individuals, patients experiencing natural RV infection, congenital rubella ..
  27. pmc Binding of cellular p32 protein to the rubella virus P150 replicase protein via PxxPxR motifs
    Suganthi Suppiah
    Department of Biology, Georgia State University, Atlanta, GA 30303, USA
    J Gen Virol 93:807-16. 2012
    A proline-rich region (PRR) within the rubella virus (RUBV) P150 replicase protein that contains three SH3 domain-binding motifs (PxxPxR) was investigated for its ability to bind cell proteins...
  28. ncbi Mutations of rubella virus vaccine TO-336 strain occurred in the attenuation process of wild progenitor virus
    J Kakizawa
    Department of Viral Disease and Vaccine Control, National Institute of Infectious Diseases, 4-7-1 Gakuen, Musashi-Murayama, Tokyo 208-0011, Japan
    Vaccine 19:2793-802. 2001
    The sequences of the genomes in the TO-336 vaccine strain (TO-336vac) of rubella virus and its wild progenitor virus (TO-336wt) have been determined and compared with each other...
  29. pmc Acute unilateral conjunctivitis after rubella vaccination: the detection of the rubella genome in the inflamed conjunctiva by reverse transcriptase-polymerase-chain reaction
    N Kitaichi
    Br J Ophthalmol 90:1436-7. 2006
  30. ncbi Rubella virus RNA replication is cis-preferential and synthesis of negative- and positive-strand RNAs is regulated by the processing of nonstructural protein
    Y Liang
    Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, V5Z 4H4, Canada
    Virology 282:307-19. 2001
    b>Rubella virus (RV) genome encodes nonstructural protein (NSP) in a large open reading frame at its 5' end. It is translated into p200 and further processed into p150 and p90...
  31. ncbi Rubella virus-associated uveitis in a nonvaccinated child
    Martin J Siemerink
    F C Donders Institute of Ophthalmology, Eijkman Winkler Center, University Medical Center Utrecht, Utrecht, The Netherlands
    Am J Ophthalmol 143:899-900. 2007
    To report presumed Fuchs heterochromic uveitis (FHU) associated with Rubella virus (RV)-specific intraocular antibody production in a child who was not vaccinated against rubella.
  32. ncbi Rubella virus glycoprotein interaction with the endoplasmic reticulum calreticulin and calnexin
    H L Nakhasi
    Laboratory of Parasitic Biology and Biochemistry, Division of Allergenic Products and Parasitology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA
    Arch Virol 146:1-14. 2001
    Very little is known about the cellular factors that are required for the maturation of rubella virus glycoproteins (E2 and E1) in the endoplasmic reticulum of the infected cell...
  33. pmc Rubella epidemics and genotypic distribution of the rubella virus in Shandong Province, China, in 1999-2010
    Changyin Wang
    Shandong Provincial Key Laboratory for Infectious Disease Control and Prevention, Shandong Center for Disease Control and Prevention, Jingshi Road, Jinan, People s Republic of China
    PLoS ONE 7:e42013. 2012
    ..The rubella vaccine was introduced into the immunization program in 1995 in the Shandong province, China. A series of different rubella vaccination strategies were implemented at different stages of measles control in Shandong province...
  34. pmc Analysis of the function of cytoplasmic fibers formed by the rubella virus nonstructural replicase proteins
    Jason D Matthews
    Georgia State University, Department of Biology, Atlanta, GA 30303, USA
    Virology 406:212-27. 2010
    The P150 and P90 replicase proteins of rubella virus (RUBV), a plus-strand RNA Togavirus, produce a unique cytoplasmic fiber network resembling microtubules...
  35. doi Three-dimensional structure of Rubella virus factories
    Juan Fontana
    Cell Structure Lab, Centro Nacional de Biotecnologia, CSIC, Darwin, Madrid, Spain
    Virology 405:579-91. 2010
    Viral factories are complex structures in the infected cell where viruses compartmentalize their life cycle. Rubella virus (RUBV) assembles factories by recruitment of rough endoplasmic reticulum (RER), mitochondria and Golgi around ..
  36. pmc The Rubella virus capsid is an anti-apoptotic protein that attenuates the pore-forming ability of Bax
    Carolina S Ilkow
    Department of Cell Biology, University of Alberta, Edmonton, Canada
    PLoS Pathog 7:e1001291. 2011
    ..Here we report that the multifunctional capsid protein of Rubella virus is a potent inhibitor of apoptosis...
  37. doi Histidine at position 1042 of the p150 region of a KRT live attenuated rubella vaccine strain is responsible for the temperature sensitivity
    Masafumi Sakata
    Laboratory of Viral Infection I, Kitasato Institute for Life Sciences, 5 9 1 Shirokane, Minato ku, 108 8641 Tokyo, Japan
    Vaccine 27:234-42. 2009
    ..JPN/68. Thus, we concluded that one mutation, of the histidine at position 1042 of p150, was essential for the ts phenotype of the KRT strain, and structural proteins of KRT had an additive effect with H1042Y on the ts phenotype...
  38. ncbi Rubella infection in pregnancy
    M De Santis
    Telefono Rosso, Teratology Information Service, Department of Obstetrics and Gynecology, Catholic University of Sacred Heart, Largo A Gemelli, 8 Rome, Italy
    Reprod Toxicol 21:390-8. 2006
    ..World wide, the aim is to perform an adequate primary prevention through vaccination of childbearing age women without specific immunological protection...
  39. ncbi Rubella virus P90 associates with the cytokinesis regulatory protein Citron-K kinase and the viral infection and constitutive expression of P90 protein both induce cell cycle arrest following S phase in cell culture
    C D Atreya
    Section of Viral Pathogenesis and Adverse Reactions, Laboratory of Pediatric and Respiratory Viral Diseases, Center for Biologics Evaluation and Research, Bethesda, Maryland 20892, USA
    Arch Virol 149:779-89. 2004
    In utero infection of developing fetus by Rubella virus (RV) causes cell division inhibition of critical precursor cells in organogenesis, CNS-associated birth defects and induction of apoptosis in cell culture...
  40. pmc Novel replicon-based reporter gene assay for detection of rubella virus in clinical specimens
    Wen Pin Tzeng
    Department of Biology, Georgia State University, 24 Peachtree Center Ave, Atlanta, GA 30303, USA
    J Clin Microbiol 43:879-85. 2005
    Proof of concept for a novel diagnostic assay for rubella virus (RUB) based on RUB replicons expressing reporter genes was demonstrated...
  41. doi Determinants of subcellular localization of the rubella virus nonstructural replicase proteins
    Jason D Matthews
    Department of Biology, Georgia State University, PO Box 4010, Atlanta, GA 30302 4010, USA
    Virology 390:315-23. 2009
    The rubella virus (RUBV) nonstructural replicase proteins (NSPs), P150 and P90, are proteolytically processed from a P200 precursor...
  42. pmc Analyses of phosphorylation events in the rubella virus capsid protein: role in early replication events
    LokMan J Law
    Department of Cell Biology, 5 14 Medical Sciences Building, University of Alberta, Edmonton, Alberta, T6G 2H7, Canada
    J Virol 80:6917-25. 2006
    The Rubella virus capsid protein is phosphorylated prior to virus assembly...
  43. pmc A refresher on rubella
    Erica Weir
    Regional Niagara Public Health Department, Thorold, Ont
    CMAJ 172:1680-1. 2005
  44. ncbi Rubella virus capsid protein modulation of viral genomic and subgenomic RNA synthesis
    Wen Pin Tzeng
    Department of Biology, Georgia State University, PO Box 4010, Atlanta, GA 30302 4010, USA
    Virology 337:327-34. 2005
    The ratio of the subgenomic (SG) to genome RNA synthesized by rubella virus (RUB) replicons expressing the green fluorescent protein reporter gene (RUBrep/GFP) is substantially higher than the ratio of these species synthesized by RUB (4...
  45. ncbi Duration of rubella immunity induced by two-dose measles, mumps and rubella (MMR) vaccination. A 15-year follow-up in Finland
    I Davidkin
    National Public Health Institute, Helsinki, Finland
    Vaccine 18:3106-12. 2000
    ..A careful surveillance including serological follow-up is therefore very important...
  46. pmc Characterization of the rubella virus nonstructural protease domain and its cleavage site
    J P Chen
    Department of Biology, Georgia State University, Atlanta, Georgia, 30303, USA
    J Virol 70:4707-13. 1996
    The region of the rubella virus nonstructural open reading frame that contains the papain-like cysteine protease domain and its cleavage site was expressed with a Sindbis virus vector...
  47. doi Positive rates for rubella antibody in pregnant women and benefit of post-partum vaccination in a Japanese perinatal center
    Mika Okuda
    Department of Obstetrics, Gynecology and Molecular Reproductive Science, Yokohama City University Graduate School of Medicine, Fukuura, Kanazawa Ku, Yokohama, Kanagawa, Japan
    J Obstet Gynaecol Res 34:168-73. 2008
    ..This study of pregnant women was undertaken to clarify their immune status for rubella and to evaluate the efficacy of, and adverse reaction to, post-partum rubella vaccination...
  48. pmc Analysis of whole genome sequences of 16 strains of rubella virus from the United States, 1961-2009
    Emily Abernathy
    National Center for Immunizations and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA
    Virol J 10:32. 2013
    b>Rubella virus is the causative agent of rubella, a mild rash illness, and a potent teratogenic agent when contracted by a pregnant woman. Global rubella control programs target the reduction and elimination of congenital rubella syndrome...
  49. ncbi Phylogenetic analysis of rubella virus including new genotype I isolates
    J Hofmann
    Institute of Virology, University of Leipzig, Johannisallee 30, 04103 Leipzig, Germany
    Virus Res 96:123-8. 2003
    Infection during the first trimester of gestation with rubella virus (RV) is highly teratogenic...
  50. ncbi Analysis of intermolecular RNA-RNA recombination by rubella virus
    Sandra D Adams
    Department of Biology, Georgia State University, Atlanta, GA 30303, USA
    Virology 309:258-71. 2003
    To investigate whether rubella virus (RUB) undergoes intermolecular RNA-RNA recombination, cells were cotransfected with pairs of in vitro transcripts from genomic cDNA plasmid vectors engineered to contain nonoverlapping deletions: the ..
  51. ncbi Maturation of IgG avidity to individual rubella virus structural proteins
    J Nedeljkovic
    Institute of Immunology and Virology, Torlak, Belgrade, Yugoslavia
    J Clin Virol 22:47-54. 2001
    BACKGROUND: the structural proteins of rubella virus, the capsid protein C and the envelope glycoproteins E1 and E2 were produced in lepidopteran insect cells using baculovirus expression vectors...
  52. pmc Mapping the rubella virus subgenomic promoter
    Wen Pin Tzeng
    Department of Biology, Georgia State University, Atlanta, Georgia 30303, USA
    J Virol 76:3189-201. 2002
    b>Rubella virus (RUB), the sole member of the Rubivirus genus in the Togaviridae family of positive-strand RNA viruses, synthesizes a single subgenomic (SG) RNA containing sequences from the 3' end of the genomic RNA including the open ..
  53. pmc Functional replacement of a domain in the rubella virus p150 replicase protein by the virus capsid protein
    Wen Pin Tzeng
    Biology Department, Georgia State University, P O Box 4010, Atlanta, GA 30302 4010, USA
    J Virol 83:3549-55. 2009
    The rubella virus (RUBV) capsid (C) protein rescues mutants with a lethal deletion between two in-frame NotI sites in the P150 replicase gene, a deletion encompassing nucleotides 1685 to 2192 of the RUBV genome and amino acids (aa) 548 ..
  54. doi Validation and application of normalization factors for gene expression studies in rubella virus-infected cell lines with quantitative real-time PCR
    S Chey
    Institute of Virology, University of Leipzig, Leipzig, Germany
    J Cell Biochem 110:118-28. 2010
    ..study was to identify and validate appropriate reference genes as internal controls for RT-qPCR experiments in rubella virus (RV)-infected Vero and MCF-7 cell lines using SYBR green fluorescence...
  55. pmc Complementation of a deletion in the rubella virus p150 nonstructural protein by the viral capsid protein
    Wen Pin Tzeng
    Department of Biology, Georgia State University, Atlanta, Georgia 30302 4010, USA
    J Virol 77:9502-10. 2003
    b>Rubella virus (RUB) replicons with an in-frame deletion of 507 nucleotides between two NotI sites in the P150 nonstructural protein (DeltaNotI) do not replicate (as detected by expression of a reporter gene encoded by the replicon) but ..
  56. pmc The rubella virus capsid protein inhibits mitochondrial import
    Carolina S Ilkow
    Department of Cell Biology, University of Alberta, Edmonton, Alberta T6G 2H7, Canada
    J Virol 84:119-30. 2010
    The rubella virus (RV) capsid is an RNA-binding protein that functions in nucleocapsid assembly at the Golgi complex, the site of virus budding...
  57. pmc Rubella virus capsid associates with host cell protein p32 and localizes to mitochondria
    M D Beatch
    Department of Cell Biology, University of Alberta, Edmonton, Alberta T6G 2H7, Canada
    J Virol 74:5569-76. 2000
    ..The assembly of rubella virus nucleocapsids is unique among togaviruses in that the process occurs late in virus assembly and in association ..
  58. ncbi A synthetic peptide ELISA for the screening of rubella virus neutralizing antibodies in order to ascertain immunity
    Andreas Giessauf
    Institut für Hygiene und Sozialmedizin, Leopold Franzens University Innsbruck, Fritz Pregl Str 3, A 6020 Innsbruck, Austria
    J Immunol Methods 287:1-11. 2004
    One hundred and fifty-one human sera from patients exposed to rubella virus (RV) and shown to be negative for IgM antibodies were tested for total RV-IgG, hemagglutination inhibition (HAI) and for virus neutralizing (VN) antibodies using ..
  59. ncbi Rubella virus capsid protein induces apoptosis in transfected RK13 cells
    R Duncan
    Laboratory of Parasitic Biology and Biochemistry, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA
    Virology 275:20-9. 2000
    b>Rubella virus is an enveloped positive-strand RNA virus that can cause mild to severe birth defects or death in an infected fetus...
  60. doi Comparison of rubella virus- and herpes virus-associated anterior uveitis: clinical manifestations and visual prognosis
    Barbara Wensing
    Department of Ophthalmology, University Medical Center Utrecht, Utrecht, The Netherlands
    Ophthalmology 118:1905-10. 2011
    To compare the clinical characteristics and visual prognosis of patients with anterior uveitis (AU) and intraocular fluid analysis positive for rubella virus (RV), herpes simplex virus (HSV), or varicella zoster virus (VZV).
  61. doi Specific IgE to allergens in cord blood is associated with maternal immunity to Toxoplasma gondii and rubella virus
    M J Ege
    University Children s Hospital, Munich, Germany
    Allergy 63:1505-11. 2008
    ..Various studies have found reduced prevalences of atopic sensitization and atopic diseases in children previously exposed to infections or living conditions with a high microbial burden, such as the farming environment...
  62. ncbi New horizons in the control of rubella and prevention of congenital rubella syndrome in the Americas
    Carlos Castillo-Solorzano
    Pan American Health Organization, Washington, DC, USA
    J Infect Dis 187:S146-52. 2003
    Data from the regional measles surveillance system have documented widespread rubella virus circulation in many different countries in the Americas...
  63. ncbi Apoptosis induction by the Therien and vaccine RA27/3 strains of rubella virus causes depletion of oligodendrocytes from rat neural cell cultures
    Lisa M Domegan
    Department of Microbiology, Moyne Institute of Preventive Medicine, Trinity College, Dublin 2, Ireland
    J Gen Virol 83:2135-43. 2002
    The induction of cell death by the Therien strain of rubella virus (RVT), and the vaccine RA27/3 strain, was investigated in mixed glial cell cultures derived from the rat CNS...
  64. ncbi An evaluation of oral-fluid collection devices for the determination of rubella antibody status in a rural Ethiopian community
    D J Nokes
    Department of Biological Sciences, University of Warwick, Coventry, UK
    Trans R Soc Trop Med Hyg 92:679-85. 1998
    ..We consider the Sponge device to be the most suitable for community survey work, although the extraction method requires improvement. Further work is needed to improve the sensitivity of antibody status determination in adults...
  65. pmc Interpreting serological surveys using mixture models: the seroepidemiology of measles, mumps and rubella in England and Wales at the beginning of the 21st century
    A J Vyse
    Health Protection Agency, Centre for Infections, Sero Epidemiology Unit, Immunisation Department, London, UK
    Epidemiol Infect 134:1303-12. 2006
    ..Investigations into the efficacy of two doses of a mumps containing vaccine should be a priority during the current epidemic...
  66. ncbi Localization of rubella virus core particles in vero cells
    J Y Lee
    Victorian Infectious Diseases Reference Laboratory, North Melbourne, Victoria, 3051, Australia
    Virology 265:110-9. 1999
    b>Rubella virus (RV) infection induces a variety of morphological changes in the host cell including the modification of lysosomes to produce "replication complexes" and the alteration of mitochondrial morphology and distribution...
  67. pmc Rubella virus E2 signal peptide is required for perinuclear localization of capsid protein and virus assembly
    L M Law
    Department of Cell Biology, University of Alberta, Edmonton, Alberta T6G 2H7, Canada
    J Virol 75:1978-83. 2001
    The rubella virus (RV) structural proteins capsid, E2, and E1 are synthesized as a polyprotein precursor...
  68. ncbi Rubella virus is associated with fuchs heterochromic iridocyclitis
    Jolanda D F de Groot-Mijnes
    Department of Virology, Eijkman Winkler Center, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Am J Ophthalmol 141:212-214. 2006
    To determine whether rubella virus (RV) is involved in the pathogenesis of Fuchs heterochromic iridocyclitis (FHI).
  69. pmc Global distribution of rubella virus genotypes
    Du Ping Zheng
    Georgia State University, Atlanta, Georgia 30303, USA
    Emerg Infect Dis 9:1523-30. 2003
    ..RGII viruses were limited to Asia and Europe; RGI viruses were also present in most of the countries where RGII viruses were isolated...
  70. ncbi Fuchs heterochromic cyclitis: rubella virus antibodies and genome in aqueous humor
    Claus D Quentin
    Department of Ophthalmology, Georg August University, Robert Koch Strasse 40, 37075 Gottingen, Germany
    Am J Ophthalmol 138:46-54. 2004
    ..To characterize the polyspecific intraocular antibody synthesis in aqueous humor of patients with chronic inflammatory diseases of the eye and to detect the causative antigen in Fuchs heterochromic cyclitis (FHC)...
  71. ncbi Acute optic neuritis: combined immunological markers and magnetic resonance imaging predict subsequent development of multiple sclerosis. The Optic Neuritis Study Group
    H Tumani
    Department of Neurology, University of Gottingen, Germany
    J Neurol Sci 155:44-9. 1998
    ..Six patients with abnormal OI but normal MRI progressed to MS. CSF and serum analyses, together with MRI, are the methods of choice for prognostic evaluation of patients with AON...
  72. doi Chaperone-aided in vitro renaturation of an engineered E1 envelope protein for detection of anti-Rubella virus IgG antibodies
    Christian Scholz
    Roche Diagnostics GmbH, Nonnenwald 2, D 82377 Penzberg, Germany
    Biochemistry 47:4276-87. 2008
    The envelope glycoproteins of Rubella virus, E1 and E2, mediate cell tropism, and E1 in particular plays a pivotal role in the fusion of the virus with the endosomal membrane. Both are the prime targets of the humoral immune response...
  73. pmc Detection of rubella virus-specific immunoglobulin G in saliva by an amplification-based enzyme-linked immunosorbent assay using monoclonal antibody to fluorescein isothiocyanate
    A J Vyse
    Enteric and Respiratory Virus Laboratory, Central Public Health Laboratory, London NW9 5HT, United Kingdom
    J Clin Microbiol 37:391-5. 1999
    An immunoglobulin G (IgG)-capture enzyme-linked immunosorbent assay (ELISA) for rubella virus is described. The assay uses a fluorescein isothiocyanate (FITC)-anti-FITC amplification system...
  74. ncbi Nested reverse transcription polymerase chain reaction for the detection of rubella virus in clinical specimens
    G Shyamala
    L and T Microbiology Research Centre, Vision Research Foundation, Sankara Nethralaya, Chennai, India
    Indian J Med Res 125:73-8. 2007
    b>Rubella virus (RV) is one of the leading causes of childhood blindness in India. In this study we applied an optimized nested reverse transcription polymerase chain reaction (nRT-PCR) to detect RV in clinical specimens.
  75. ncbi Time-course induction of apoptosis by wild-type and attenuated strains of rubella virus
    Samantha Cooray
    Department of Infection, Virology Section, St Thomas s Hospital, Lambeth Palace Road, London SE1 7EH, UK
    J Gen Virol 84:1275-9. 2003
    The time-course of rubella virus (RV)-induced apoptosis was studied in RK13 cells...
  76. pmc Simultaneous detection of measles virus, rubella virus, and parvovirus B19 by using multiplex PCR
    María del Mar Mosquera
    Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Majadahonda, Spain
    J Clin Microbiol 40:111-6. 2002
    ..here a multiplex reverse transcription-PCR (RTMNPCR) assay designed to detect and differentiate measles virus, rubella virus, and parvovirus B19...
  77. doi Rubella virus-associated uveitis: clinical manifestations and visual prognosis
    Lenneke de Visser
    Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, The Netherlands
    Am J Ophthalmol 146:292-7. 2008
    To investigate the clinical profile of patients with chronic anterior uveitis and intraocular analyses positive for intraocular Rubella virus infection and assess eventual similarities to Fuchs heterochromic uveitis (FHU).
  78. ncbi Effects of endocytosis inhibitory drugs on rubella virus entry into VeroE6 cells
    Sun Ho Kee
    Department of Microbiology, College of Medicine, The Institute for Viral Diseases, Medical Science Research Center, Korea University, Seoul
    Microbiol Immunol 48:823-9. 2004
    It has been suggested that infectious entry of rubella virus (RV) is conducted by receptor mediated endocytosis...
  79. pmc Interactions between rubella virus capsid and host protein p32 are important for virus replication
    Martin D Beatch
    Department of Cell Biology, 5 14 Medical Sciences Building, University of Alberta, Edmonton, AB T6G 2H7, Canada
    J Virol 79:10807-20. 2005
    The distribution and morphology of mitochondria are dramatically affected during infection with rubella virus (RV)...
  80. ncbi Prevalence of HI antibody titer against rubella virus to determine the effect of mass vaccination in Tehran
    H Soleimanjahi
    Department of Virology, Faculty of Medical Sciences, Tarbiat Modarres University, Tehran, Iran
    J Clin Virol 34:153-4. 2005
    ..Mass vaccination campaigns and Expanded Program of Immunization (EPI) have increased vaccine coverage in the world with a substantial impact on the reduction of rubella infections, such as CRS...
  81. ncbi Molecular analysis of rubella virus epidemiology across three continents, North America, Europe, and Asia, 1961-1997
    T K Frey
    Department of Biology, Georgia State University, Atlanta 30303, USA
    J Infect Dis 178:642-50. 1998
    E1 gene nucleotide sequences of 63 rubella virus isolates from North America, Europe, and Asia isolated between 1961 and 1997 were compared phylogenetically...
  82. pmc The role of RT-PCR assay of oral fluid for diagnosis and surveillance of measles, mumps and rubella
    L Jin
    Bull World Health Organ 80:76-7. 2002
  83. ncbi An RT-PCR assay using oral fluid samples to detect rubella virus genome for epidemiological surveillance
    A J Vyse
    Enteric, Respiratory and Neurological Virus Laboratory, Central Public Health Laboratory, London, NW9 5HT, UK
    Mol Cell Probes 16:93-7. 2002
    A reverse transcription nested polymerase chain reaction (RT-PCR) method was developed for detecting rubella virus (RV) RNA using primer pairs which targeted a variable region of the E1 gene...
  84. pmc Rubella virus capsid protein interacts with poly(a)-binding protein and inhibits translation
    Carolina S Ilkow
    Department of Cell Biology, University of Alberta, 5 14 Medical Sciences Building, Edmonton, Alberta T6G 2H7, Canada
    J Virol 82:4284-94. 2008
    ..Here we report that the rubella virus (RV) capsid protein binds to poly(A)-binding protein (PABP), a host cell protein that enhances translational ..
  85. ncbi The rubella virus putative replicase interacts with the retinoblastoma tumor suppressor protein
    C D Atreya
    Division of Viral Products, University of Leipzig, Germany
    Virus Genes 16:177-83. 1998
    In utero fetal infection of rubella virus (RV), a positive-stranded RNA virus, frequently induces birth defects if contracted in the first trimester of pregnancy. The underlying mechanism of RV-induced birth defects is not known...
  86. ncbi The changing epidemiology of rubella in the 1990s: on the verge of elimination and new challenges for control and prevention
    Susan E Reef
    National Immunization Program, Centers for Disease Control and Prevention, 1600 Clifton Rd NE, MS E 61, Atlanta, GA 30333, USA
    JAMA 287:464-72. 2002
    ..Reported rubella cases are at record low levels; however, cases and outbreaks have occurred, primarily among unvaccinated foreign-born adults...
  87. ncbi The Measles Laboratory Network in the region of the Americas
    Linda Venczel
    Pan American Health Organization, Washington, DC, USA
    J Infect Dis 187:S140-5. 2003
    ..The priority given to the laboratories in the Network must continue in order to ensure that the eradication goal is reached and that validation of the interruption of endemic transmission of measles is documented...
  88. ncbi Rubella susceptibility predicts measles susceptibility: implications for postpartum immunization
    M D Libman
    Saint Mary s Hospital, Montreal, Quebec, Canada
    Clin Infect Dis 31:1501-3. 2000
    ..2% were also measles susceptible, whereas only 0.8% of the rubella-immune women were measles susceptible. Susceptibility to mumps was evenly divided between rubella-susceptible (7.8%) and rubella-immune (7.4%) groups...
  89. ncbi Sequence of the genome RNA of rubella virus: evidence for genetic rearrangement during togavirus evolution
    G Dominguez
    Department of Biology, Georgia State University, Atlanta 30302 4010
    Virology 177:225-38. 1990
    The nucleotide sequence of the rubella virus (RUB) genomic RNA was determined. The RUB genomic RNA is 9757 nucleotides in length [excluding the poly(A) tail] and has a G/C content of 69.5%, the highest of any RNA virus sequenced to data...
  90. ncbi Prevalence of antibodies against rubella virus in Spain
    Jose Maria Eiros Bouza
    Clin Infect Dis 44:465-6. 2007
  91. ncbi Factors associated with low immunity to rubella infection on antenatal screening
    Deshanie Sathanandan
    Public Health Unit, Sydney South West Area Health Service, Eastern Zone, Sydney, Australia
    Aust N Z J Obstet Gynaecol 45:435-8. 2005
    ..This study examined the level of rubella immunity in pregnant women in a part of Sydney and risk factors for non-immunity...
  92. ncbi High rubella seronegativity in daycare educators
    Theresa W Gyorkos
    Department of Epidemiology and Biostatistics, McGill University, Montreal, Quebec, Canada
    Clin Invest Med 28:105-11. 2005
    ..The purpose of the study was to generate new evidence on the magnitude of rubella seronegativity and associated risk factors in daycare centre educators...
  93. ncbi Waning antibodies in measles and rubella vaccinees--a longitudinal study
    Jacques R Kremer
    Institute of Immunology and WHO Collaborative Centre for Measles and WHO European Regional Reference Laboratory for Measles and Rubella, Laboratoire National de Santé, 20A, rue Auguste Lumiere, L 1011, Luxembourg
    Vaccine 24:2594-601. 2006
    ..However, as a result of a more rapid decay of high-titre (> 1500 mIU) antibodies (-2.4%/year), many vaccinees may eventually become susceptible to vaccine-modified measles (VMM) and consequently complicate measles control strategies...
  94. ncbi [Rubella vaccine]
    Keiichiro Yoneyama
    Health Service Center, Showa University
    Nihon Rinsho 63:607-11. 2005
  95. ncbi Open randomized trial comparing the immunogenicity and safety of a new measles-mumps-rubella vaccine and a licensed vaccine in 12- to 24-month-old children
    Cornelia Feiterna-Sperling
    Charite University Medicine Berlin, Berlin, Germany
    Pediatr Infect Dis J 24:1083-8. 2005
    ..This study compared the immunogenicity and safety of MMR Berna, which is produced entirely in human diploid cells, with those of the licensed vaccine M-M-RVax (Merck & Co.)...
  96. pmc Rubella and measles seroprevalence among women of childbearing age, Argentina, 2002
    G H Dayan
    Epidemiology and Surveillance Division, National Immunization Program, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Epidemiol Infect 133:861-9. 2005
    ..Our findings support the introduction of supplemental immunization activities targeting adolescents and young adults to prevent congenital rubella syndrome and measles outbreaks over time...
  97. ncbi Reducing the global burden of congenital rubella syndrome: report of the World Health Organization Steering Committee On Research Related To Measles and Rubella Vaccines and Vaccination, June 2004
    Jennifer M Best
    Department of Infectious Diseases, King s College London School of Medicine, London, United Kingdom
    J Infect Dis 192:1890-7. 2005
    ..and vaccine-induced immunity to rubella, laboratory diagnosis, the molecular epidemiological profile of rubella virus, and mathematical modeling to assess the burden of CRS and the impact of rubella vaccination was reviewed...
  98. ncbi Investigation of measles and rubella outbreaks in Tamil Nadu, India-2003
    Nalini Ramamurty
    Department of Virology, King Institute of Preventive Medicine, Guindy, Chennai, India
    J Med Virol 78:508-13. 2006
    ..It is necessary to be aware of the circulating genotypes within the geographical area. The information would be valuable to evaluate control measures and identify viral transmission and importation...
  99. ncbi Rubella prevalence and its transmission in children
    Anita Chakravarti
    Department of Microbiology, Maulana Azad Medical College, New Delhi
    Indian J Pathol Microbiol 49:54-6. 2006
    ..27%) were positive for IgM antibodies. The transmission rate of rubella virus from mother to child when the mother was infected was around 55.55% according to this study...
  100. ncbi A rubella serosurvey in postpartum women in the three regions of Peru
    Luis Suarez-Ognio
    General Office of Epidemiology, Ministry of Health, Lima, Peru
    Rev Panam Salud Publica 22:110-7. 2007
    ..To determine the proportion of postpartum women aged 15-49 in Peru who are susceptible to rubella, in order to help address strategies to eliminate rubella and to prevent congenital rubella syndrome (CRS) in the country...
  101. doi Immunogenicity and safety assessments after one and two doses of a refrigerator-stable tetravalent measles-mumps-rubella-varicella vaccine in healthy children during the second year of life
    Volker Schuster
    Hospital for Children and Adolescents, University of Leipzig, Leipzig, Germany
    Pediatr Infect Dis J 27:724-30. 2008
    ..This study (104389/NCT00127023) was undertaken to assess the immunogenicity and safety of a new refrigerator-stable tetravalent MMRV vaccine after 1 dose and after 2 doses administered during the second year of life...

Research Grants81

  1. MOLECULAR BIOLOGY OF RUBELLA VIRUS
    TERYL FREY; Fiscal Year: 2006
    b>Rubella virus (RUB), the sole member of the Rubivirus genus in the Togavirus family of RNA viruses, is a major human pathogen that is the most potent teratogen of an infectious nature...
  2. MOLECULAR BIOLOGY OF RUBELLA VIRUS
    TERYL FREY; Fiscal Year: 1993
    b>Rubella virus is a human pathogen which can cause birth defects in pregnant women and long term virus persistence in some individuals. The implications of rubella persistence are incompletely understood...
  3. Immune Regulation of CNS Viral Recrudescence
    Cornelia Bergmann; Fiscal Year: 2007
    ..e. measles virus, rubella virus, JC virus, and HIV...
  4. Immune Regulation of CNS Viral Recrudescence
    Cornelia Bergmann; Fiscal Year: 2010
    ..e. measles virus, rubella virus, JC virus, and HIV...
  5. Immune Regulation of CNS Viral Recrudescence
    Cornelia Bergmann; Fiscal Year: 2009
    ..e. measles virus, rubella virus, JC virus, and HIV...
  6. Prenatal Factors and Risk of Bipolar Disorder
    Alan Brown; Fiscal Year: 2007
    ....
  7. Prenatal Factors and Risk of Bipolar Disorder
    Alan Brown; Fiscal Year: 2009
    ....
  8. Prenatal Factors and Risk of Schizophrenia in a Finnish National Birth Cohort
    ALAN STEWART BROWN; Fiscal Year: 2010
    ..Moreover, the research described in this proposal has future potential for the identification of susceptibility genes that interact with the prenatal exposures and other developmental antecedents in the etiology of schizophrenia. ..
  9. MOLECULAR BIOLOGY OF RUBELLA VIRUS
    TERYL FREY; Fiscal Year: 2000
    b>Rubella virus (RUB) is a major human pathogen. RUB infection during pregnancy can lead to severe birth defects (congenital rubella syndrome or CRS). Rubella is controlled in the U.S. by use of live, attenuated vaccines...
  10. Prenatal Factors and Risk of Schizophrenia in a Finnish National Birth Cohort
    Alan Brown; Fiscal Year: 2009
    ..Moreover, the research described in this proposal has future potential for the identification of susceptibility genes that interact with the prenatal exposures and other developmental antecedents in the etiology of schizophrenia. ..
  11. DEVELOPMENTAL INSULT AND BRAIN ANOMALY IN SCHIZOPHRENIA
    Alan Brown; Fiscal Year: 2004
    ....
  12. Serologic Studies of Prenatal Factors in Schizophrenia
    Alan Brown; Fiscal Year: 2002
    ..For this purpose, we shall quantify levels of these cytokines in 100 SSD cases and their respective matched controls, and compare these levels between the groups. ..
  13. EPIDEMIOLOGY OF PRENATAL EXPOSURES IN SCHIZOPHRENIA
    Alan Brown; Fiscal Year: 2007
    ..In the genetics section of the proposal, I will test models of gene-environment interaction. ..
  14. DEVELOPMENTAL INSULT AND BRAIN ANOMALY IN SCHIZOPHRENIA
    Alan Brown; Fiscal Year: 2003
    ..This relatively new approach promises to yield more integrative, stable results than are possible with older analytic techniques that focus on separate and individual cognitive and neuroimagin 9 measures. ..