sindbis virus

Summary

Summary: The type species of ALPHAVIRUS normally transmitted to birds by CULEX mosquitoes in Egypt, South Africa, India, Malaya, the Philippines, and Australia. It may be associated with fever in humans. Serotypes (differing by less than 17% in nucleotide sequence) include Babanki, Kyzylagach, and Ockelbo viruses.

Top Publications

  1. ncbi Properties of Sindbis virus vectors produced with a chimeric split helper system
    Anna Ketola
    AI Virtanen Institute, Department of Biotechnology and Molecular Medicine, University of Kuopio, Kuopio, Finland
    Int J Mol Med 15:999-1003. 2005
  2. ncbi Autophagy protects against Sindbis virus infection of the central nervous system
    Anthony Orvedahl
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, 75390, USA
    Cell Host Microbe 7:115-27. 2010
  3. ncbi Protection against fatal Sindbis virus encephalitis by beclin, a novel Bcl-2-interacting protein
    X H Liang
    Departments of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Virol 72:8586-96. 1998
  4. ncbi Identification of interferon-stimulated gene 15 as an antiviral molecule during Sindbis virus infection in vivo
    Deborah J Lenschow
    Department of Pathology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Virol 79:13974-83. 2005
  5. ncbi Adaptation of Sindbis virus to BHK cells selects for use of heparan sulfate as an attachment receptor
    W B Klimstra
    Department of Microbiology and Immunology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    J Virol 72:7357-66. 1998
  6. ncbi Luciferase imaging of a neurotropic viral infection in intact animals
    Susan H Cook
    W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    J Virol 77:5333-8. 2003
  7. ncbi Roles of nonstructural protein nsP2 and Alpha/Beta interferons in determining the outcome of Sindbis virus infection
    Elena I Frolova
    Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas 77555 1019, USA
    J Virol 76:11254-64. 2002
  8. ncbi Characterization of purified Sindbis virus nsP4 RNA-dependent RNA polymerase activity in vitro
    Jon K Rubach
    Department of Biological Chemistry, Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA
    Virology 384:201-8. 2009
  9. ncbi Sindbis virus usurps the cellular HuR protein to stabilize its transcripts and promote productive infections in mammalian and mosquito cells
    Kevin J Sokoloski
    Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523 1682, USA
    Cell Host Microbe 8:196-207. 2010
  10. ncbi Selection and characterization of packaging cell lines for XJ-160 virus
    Wu Yang Zhu
    State Key Laboratory for Infectious Disease Prevention and Control, Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, 100 Yingxin Street, Beijing, China
    Intervirology 52:100-6. 2009

Research Grants

  1. MR and BL Tracking of Stem/Progenitor Cells in the CNS
    Jeff W Bulte; Fiscal Year: 2010
  2. Mechanisms of apoptosis in the central nervous system
    Kenneth Tyler; Fiscal Year: 2009
  3. A Sindbis virus-based Vaccine Against RVFV Infection
    Ilya Frolov; Fiscal Year: 2006
  4. Characterization of the La Crosse Virus glycoprotein fusion peptide
    Francisco Gonzalez Scarano; Fiscal Year: 2010
  5. Characterization of the La Crosse Virus glycoprotein fusion peptide
    Francisco Gonzalez Scarano; Fiscal Year: 2009
  6. Replicon-based screening for inhibitors of alphaviruses
    PAUL OLIVO; Fiscal Year: 2005
  7. A Viral Vector for Gene Expression in Insects
    Ranjit Dasgupta; Fiscal Year: 2007
  8. A Viral Vector for Gene Expression in Insects
    Ranjit Dasgupta; Fiscal Year: 2003
  9. Regulation of Sindbis Virus Subgenomic RNA Synthesis
    Victor Stollar; Fiscal Year: 2010
  10. Regulation of Sindbis Virus Subgenomic RNA Synthesis
    Victor Stollar; Fiscal Year: 2007

Detail Information

Publications250 found, 100 shown here

  1. ncbi Properties of Sindbis virus vectors produced with a chimeric split helper system
    Anna Ketola
    AI Virtanen Institute, Department of Biotechnology and Molecular Medicine, University of Kuopio, Kuopio, Finland
    Int J Mol Med 15:999-1003. 2005
    We have evaluated a chimeric, two-component Sindbis virus packaging system...
  2. ncbi Autophagy protects against Sindbis virus infection of the central nervous system
    Anthony Orvedahl
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, 75390, USA
    Cell Host Microbe 7:115-27. 2010
    ..Here, we report that the autophagy gene Atg5 function is critical for protection against lethal Sindbis virus (SIN) infection of the mouse central nervous system...
  3. ncbi Protection against fatal Sindbis virus encephalitis by beclin, a novel Bcl-2-interacting protein
    X H Liang
    Departments of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Virol 72:8586-96. 1998
    bcl-2, the prototypic cellular antiapoptotic gene, decreases Sindbis virus replication and Sindbis virus-induced apoptosis in mouse brains, resulting in protection against lethal encephalitis...
  4. ncbi Identification of interferon-stimulated gene 15 as an antiviral molecule during Sindbis virus infection in vivo
    Deborah J Lenschow
    Department of Pathology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Virol 79:13974-83. 2005
    ..To identify additional IFN-induced antiviral molecules, we utilized a recombinant chimeric Sindbis virus to express selected ISGs in IFN-alpha/beta receptor (IFN-alpha/betaR)(-/-) mice and looked for attenuation of ..
  5. ncbi Adaptation of Sindbis virus to BHK cells selects for use of heparan sulfate as an attachment receptor
    W B Klimstra
    Department of Microbiology and Immunology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    J Virol 72:7357-66. 1998
    Attachment of Sindbis virus to the cell surface glycosaminoglycan heparan sulfate (HS) and the selection of this phenotype by cell culture adaptation were investigated...
  6. ncbi Luciferase imaging of a neurotropic viral infection in intact animals
    Susan H Cook
    W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    J Virol 77:5333-8. 2003
    ..b>Sindbis virus causes encephalomyelitis in mice, and the outcome of infection is determined both by the strain of virus used ..
  7. ncbi Roles of nonstructural protein nsP2 and Alpha/Beta interferons in determining the outcome of Sindbis virus infection
    Elena I Frolova
    Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas 77555 1019, USA
    J Virol 76:11254-64. 2002
    Alphaviruses productively infect a variety of vertebrate and insect cell lines. In vertebrate cells, Sindbis virus redirects cellular processes to meet the needs of virus propagation...
  8. ncbi Characterization of purified Sindbis virus nsP4 RNA-dependent RNA polymerase activity in vitro
    Jon K Rubach
    Department of Biological Chemistry, Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA
    Virology 384:201-8. 2009
    The Sindbis virus RNA-dependent RNA polymerase (nsP4) is responsible for the replication of the viral RNA genome. In infected cells, nsP4 is localized in a replication complex along with the other viral non-structural proteins...
  9. ncbi Sindbis virus usurps the cellular HuR protein to stabilize its transcripts and promote productive infections in mammalian and mosquito cells
    Kevin J Sokoloski
    Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523 1682, USA
    Cell Host Microbe 8:196-207. 2010
    ..We demonstrate that Sindbis virus, a prototypical single-stranded arthropod-borne alphavirus, uses U-rich 3' UTR sequences in its RNAs to ..
  10. ncbi Selection and characterization of packaging cell lines for XJ-160 virus
    Wu Yang Zhu
    State Key Laboratory for Infectious Disease Prevention and Control, Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, 100 Yingxin Street, Beijing, China
    Intervirology 52:100-6. 2009
    ..XJ-160 virus is a mosquito-derived Sindbis-like virus isolated in China. Based on its infectious clone (pBR-XJ-160) we have developed an RNA-based vector system. In this work, we constructed packaging cell lines (PCLs) for XJ-160 virus...
  11. ncbi Interaction of E2 glycoprotein with heparan sulfate is crucial for cellular infection of Sindbis virus
    Wuyang Zhu
    Department of Viral Encephalitis, Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, and State Key Laboratory for Infectious Disease Prevention and Control SKLID, Beijing, China
    PLoS ONE 5:e9656. 2010
    Cell culture-adapted strains of Sindbis virus (SINV) initially attach to cells by the ability to interact with heparan sulfate (HS) through selective mutation for positively charged amino acid (aa) scattered in E2 glycoprotein (W. B...
  12. ncbi Engineered lentivector targeting of dendritic cells for in vivo immunization
    Lili Yang
    Division of Biology, California Institute of Technology, 1200 E California Blvd, Pasadena, California 91125, USA
    Nat Biotechnol 26:326-34. 2008
    ..To target dendritic cells, we enveloped the lentivector with a viral glycoprotein from Sindbis virus engineered to be DC-SIGN-specific...
  13. ncbi Bax-independent inhibition of apoptosis by Bcl-XL
    E H Cheng
    Department of Neurology, Johns Hopkins School of Medicine, Baltimore, Maryland 21287 7681, USA
    Nature 379:554-6. 1996
    ..mutagenesis, we show here that the amino-acid residues critical for protection of cells by Bcl-XL against Sindbis virus-induced apoptosis are clustered within the Bcl-2-homology regions 1 and 2 (BH1 and BH2 regions)...
  14. ncbi Systemic tumor targeting and killing by Sindbis viral vectors
    Jen-Chieh Tseng
    New York University Gene Therapy Center, NYU Cancer Institute, NYU School of Medicine, 550 First Avenue, New York, New York 10016, USA
    Nat Biotechnol 22:70-7. 2004
    ..The vectors can also target syngeneic and spontaneous tumors in immune-competent mice. We document the anti-tumor specificity of a vector that systemically targets and eradicates tumor cells throughout the body without adverse effects...
  15. ncbi Alphavirus-derived small RNAs modulate pathogenesis in disease vector mosquitoes
    Kevin M Myles
    Department of Entomology, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA
    Proc Natl Acad Sci U S A 105:19938-43. 2008
    ..These results suggest that an exogenous siRNA pathway is essential to the survival of mosquitoes infected with alphaviruses and, thus, the maintenance of these viruses in nature...
  16. ncbi Host factors associated with the Sindbis virus RNA-dependent RNA polymerase: role for G3BP1 and G3BP2 in virus replication
    Ileana M Cristea
    Department of Molecular Biology, Princeton University, Lewis Thomas Laboratory, Washington Road, Princeton, New Jersey 08544, USA
    J Virol 84:6720-32. 2010
    b>Sindbis virus (SINV) is the prototype member of the Alphavirus genus, whose members cause severe human diseases for which there is no specific treatment...
  17. ncbi Exposure to low pH is not required for penetration of mosquito cells by Sindbis virus
    R Hernandez
    Department of Molecular and Structural Biochemistry, North Carolina State University, Raleigh, North Carolina 27695, USA
    J Virol 75:2010-3. 2001
    ..The alphavirus Sindbis virus replicates in both vertebrate and invertebrate cell cultures...
  18. ncbi The cellular antiviral protein viperin is attenuated by proteasome-mediated protein degradation in Japanese encephalitis virus-infected cells
    Yi Lin Chan
    Graduate Institute of Life Sciences, National Defense Medical Center, Institute of Biomedical Sciences, Taipei, Taiwan, Republic of China
    J Virol 82:10455-64. 2008
    ..this study, we found that viperin is highly induced at the RNA level by Japanese encephalitis virus (JEV) and Sindbis virus (SIN) and that viperin protein is degraded in JEV-infected cells through a proteasome-dependent mechanism...
  19. ncbi Identification of a dominant negative inhibitor of human zinc finger antiviral protein reveals a functional endogenous pool and critical homotypic interactions
    Lok Man J Law
    Laboratory of Virology and Infectious Disease, The Rockefeller University, 1230 York Ave, New York, NY 10065, USA
    J Virol 84:4504-12. 2010
    ..ZAP blocks replication of the prototype alphavirus Sindbis virus (SINV) at a step at or before translation of the incoming viral genome...
  20. ncbi A luciferase-based screening method for inhibitors of alphavirus replication applied to nucleoside analogues
    Leena Pohjala
    Program in Cellular Biotechnology, Institute of Biotechnology, P O Box 56 Viikinkaari 9, University of Helsinki, 00014 Helsinki, Finland
    Antiviral Res 78:215-22. 2008
    ..inhibitors of Semliki Forest virus (SFV) replication, and demonstrate the effects of 29 nucleosides on SFV and Sindbis virus replication...
  21. ncbi Sindbis virus-induced neuronal death is both necrotic and apoptotic and is ameliorated by N-methyl-D-aspartate receptor antagonists
    J L Nargi-Aizenman
    W. Harry Feinstone Department of Molecular Microbiology and Immunology, School of Hygiene and Public Health, Johns Hopkins University, Baltimore, Maryland 21205, USA
    J Virol 75:7114-21. 2001
    ..b>Sindbis virus (SV) is an alphavirus that induces apoptotic cell death both in vitro and in vivo...
  22. ncbi Selection of functional 5' cis-acting elements promoting efficient sindbis virus genome replication
    Rodion Gorchakov
    Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas 77555-1019, USA
    J Virol 78:61-75. 2004
    The 5' portion of the Sindbis virus (SIN) genome RNA is multifunctional...
  23. ncbi Cis-acting RNA elements at the 5' end of Sindbis virus genome RNA regulate minus- and plus-strand RNA synthesis
    I Frolov
    Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston 77555-1019, USA
    RNA 7:1638-51. 2001
    ..In addition to providing new insight into the initiation of alphavirus genome replication, these results have implications for the development of improved alphavirus vector systems with reduced recombination potential...
  24. ncbi Individual expression of sindbis virus glycoproteins. E1 alone promotes cell fusion
    Miguel Angel Sanz
    Centro de Biologia Molecular CSIC UAM, Universidad Autonoma, Cantoblanco, 28049 Madrid, Spain
    Virology 305:463-72. 2003
    ..each glycoprotein in the absence of the other counterpart was achieved by means of electroporation of modified Sindbis virus (SV) genomes. In addition, in trans coexpression of both glycoproteins was also tested in BHK cells...
  25. ncbi The nsP3 macro domain is important for Sindbis virus replication in neurons and neurovirulence in mice
    Eunhye Park
    W Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health and Cellular and Molecular Medicine Graduate Program, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    Virology 388:305-14. 2009
    b>Sindbis virus (SINV), the prototype alphavirus, contains a macro domain in the highly conserved N-terminal region of nonstructural protein 3 (nsP3). However, the biological role of the macro domain is unclear...
  26. ncbi Infection of cells by Sindbis virus at low temperature
    Gongbo Wang
    Department of Molecular and Structural Biochemistry, North Carolina State University, Raleigh, NC 27695, USA
    Virology 362:461-7. 2007
    b>Sindbis virus, which belongs to the family Togaviridae genus Alphavirus infects a variety of vertebrate and invertebrate cells. The initial steps of Sindbis virus infection involve attachment, penetration and uncoating...
  27. ncbi Functional Sindbis virus replicative complexes are formed at the plasma membrane
    Elena I Frolova
    Department of Microbiology, University of Alabama, Birmingham, AL 35294 2170, USA
    J Virol 84:11679-95. 2010
    ..However, our recent studies have demonstrated that Sindbis virus (SINV)-specific, double-stranded RNA (dsRNA)- and nonstructural protein (nsP)-containing RCs are initially ..
  28. ncbi A determinant of Sindbis virus neurovirulence enables efficient disruption of Jak/STAT signaling
    Jason D Simmons
    Department of Genetics, The Carolina Vaccine Institute, University of North Carolina at Chapel Hill, 9039 Burnett Womack Bldg, CB 7292, Chapel Hill, NC 27599, USA
    J Virol 84:11429-39. 2010
    Previous studies with Venezuelan equine encephalitis virus and Sindbis virus (SINV) indicate that alphaviruses are capable of suppressing the cellular response to type I and type II interferons (IFNs) by disrupting Jak/STAT signaling; ..
  29. ncbi Translation driven by picornavirus IRES is hampered from Sindbis virus replicons: rescue by poliovirus 2A protease
    Miguel Angel Sanz
    Centro de Biologia Molecular Severo Ochoa, CSIC UAM, C Nicolás Cabrera, 1, Universidad Autonoma, Cantoblanco, 28049 Madrid, Spain
    J Mol Biol 402:101-17. 2010
    ..We have investigated the translatability of Sindbis virus (SV) subgenomic mRNA bearing different 5'-untranslated regions, including several viral internal ribosome ..
  30. ncbi Sindbis viral vector induced apoptosis requires translational inhibition and signaling through Mcl-1 and Bak
    Lisa Venticinque
    NYU Cancer Institute and the NYU Gene Therapy Center, NYU School of Medicine, 550 First Avenue, New York, NY 10016, USA
    Mol Cancer 9:37. 2010
    ..A comprehensive understanding of the mechanism of apoptosis would facilitate the design of more effective vectors for cancer therapy...
  31. ncbi Redirecting lentiviral vectors pseudotyped with Sindbis virus-derived envelope proteins to DC-SIGN by modification of N-linked glycans of envelope proteins
    Kouki Morizono
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, BSRB 173, Charles E Young Dr South, Los Angeles, CA 90095, USA
    J Virol 84:6923-34. 2010
    ..We previously developed targeting lentiviral vectors by pseudotyping with modified Sindbis virus envelope proteins...
  32. ncbi Amino acid substitutions in the E2 glycoprotein of Sindbis-like virus XJ-160 confer the ability to undergo heparan sulfate-dependent infection of mouse embryonic fibroblasts
    Wuyang Zhu
    State Key Laboratory for Infectious Disease Prevention and Control SKLID, Institute for Viral Disease Control and Prevention, China CDC, Beijing, China
    Virol J 7:225. 2010
    We have recently demonstrated an essential role of the domain of 145-150 amino acid in the E2 glycoprotein of Sindbis virus in the interaction with cellular heparan sulfate (HS) and in the infection of mouse embryonic fibroblasts (MEF) ..
  33. ncbi Substitutions of 169Lys and 173Thr in nonstructural protein 1 influence the infectivity and pathogenicity of XJ-160 virus
    Wu Yang Zhu
    State Key Laboratory for Infectious Disease Control and Prevention, Institute for Viral Disease Control and Prevention, China CDC, 100 Yingxin Street, Xuan Wu District, 100052 Beijing, China
    Arch Virol 154:245-53. 2009
    ..These mutations might be associated with the RNA methyltransferase (MTase) activity of nsP1...
  34. ncbi Sindbis viruses and other alphaviruses as cause of human arthritic disease
    M Laine
    Keuruu Health Center, Keuruu, Finland
    J Intern Med 256:457-71. 2004
    ..Several factors related to the viruses, their hosts, and global environmental changes may affect the spread of these viruses. All over the world arbovirus-caused diseases have increased, because of global changes...
  35. ncbi The zinc finger antiviral protein directly binds to specific viral mRNAs through the CCCH zinc finger motifs
    Xuemin Guo
    Institute of Microbiology, Chinese Academy of Sciences, Beijing 100080, China
    J Virol 78:12781-7. 2004
    ..It specifically inhibits the replication of Moloney murine leukemia virus (MLV) and Sindbis virus (SIN) by preventing the accumulation of viral RNA in the cytoplasm...
  36. ncbi Inhibition of virus-induced neuronal apoptosis by Bax
    J Lewis
    Department of Pharmacology and Molecular Sciences, Johns Hopkins University Schools of Medicine and Public Health, Baltimore, Maryland 21205, USA
    Nat Med 5:832-5. 1999
    ..However, Bax was found here to be a potent inhibitor of neuronal cell death in mice infected with Sindbis virus. Newborn mice, which are highly susceptible to a fatal infection with neurotropic Sindbis virus, were ..
  37. ncbi Tumor-specific in vivo transfection with HSV-1 thymidine kinase gene using a Sindbis viral vector as a basis for prodrug ganciclovir activation and PET
    Jen-Chieh Tseng
    NYU Cancer Institute, Rita J. and Stanley H. Kaplan Comprehensive Cancer Center, NYU Gene Therapy Center, NYU School of Medicine, New York, New York 10016, USA
    J Nucl Med 47:1136-43. 2006
    ..b>Sindbis virus is an oncolytic, alpha-virus that selectively targets tumors through the 67-kDa laminin receptor (LAMR)...
  38. ncbi Placement of the structural proteins in Sindbis virus
    Wei Zhang
    Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907-1392, USA
    J Virol 76:11645-58. 2002
    The structure of the lipid-enveloped Sindbis virus has been determined by fitting atomic resolution crystallographic structures of component proteins into an 11-A resolution cryoelectron microscopy map...
  39. ncbi Effects of inducing or inhibiting apoptosis on Sindbis virus replication in mosquito cells
    Hua Wang
    Molecular, Cellular, and Developmental Biology Program, Arthropod Genomics Center, Division of Biology, Kansas State University, Manhattan, KS 66506, USA
    J Gen Virol 89:2651-61. 2008
    b>Sindbis virus (SINV) is a mosquito-borne virus in the genus Alphavirus, family Togaviridae...
  40. ncbi vFLIP protects PC-12 cells from apoptosis induced by Sindbis virus: implications for the role of TNF-alpha
    R Sarid
    Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel 52900
    Cell Death Differ 8:1224-31. 2001
    b>Sindbis virus (SV) is an alphavirus used as a model for studying the pathogenesis of viral encephalitis...
  41. ncbi Interferon-gamma-mediated site-specific clearance of alphavirus from CNS neurons
    G K Binder
    W Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Science 293:303-6. 2001
    ..To understand the role of T cells in clearance, we infected antibody knockout mice with Sindbis virus. Virus was cleared from spinal cord and brain stem neurons, but not from cortical neurons, and required both ..
  42. ncbi A heterologous coiled coil can substitute for helix I of the Sindbis virus capsid protein
    Rushika Perera
    Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907, USA
    J Virol 77:8345-53. 2003
    ..This sequence, which spans residues 38 to 55 of the Sindbis virus capsid protein, was implicated in stabilizing dimeric contacts initiated through the C-terminal two-thirds of ..
  43. ncbi Aedes aegypti uses RNA interference in defense against Sindbis virus infection
    Corey L Campbell
    Arthropod borne Infectious Diseases Laboratory Microbiology, Immunology, and Pathology Department, Colorado State University, Fort Collins, USA
    BMC Microbiol 8:47. 2008
    ..The goal of this study was to use Ae. aegypti as a model system to determine how the mosquito's anti-viral RNAi pathway interacts with recombinant Sindbis virus (SINV; family Togaviridae, genus Alphavirus).
  44. ncbi Identity of Karelian fever and Ockelbo viruses determined by serum dilution-plaque reduction neutralization tests and oligonucleotide mapping
    D K Lvov
    D I Ivanovsky Institute of Virology, USSR Academy of Medical Sciences, Moscow
    Am J Trop Med Hyg 39:607-10. 1988
    ..Finland, and Karelian fever in the USSR have been attributed to alphaviruses (family Togaviridae) related to Sindbis virus. We compared prototypes Sindbis, Ockelbo, and Karelian fever viruses by neutralization tests...
  45. ncbi Susceptibility of colorectal cancer cells to Sindbis virus infection
    Chao Li
    Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73190, USA
    J Exp Ther Oncol 8:167-75. 2009
    b>Sindbis virus (SIN), a member of the Togaviridae family, infects a broad range of cells and has been shown to be an effective anti-tumor agent. The infection efficiency of the virus, however, varies greatly among target cells...
  46. ncbi IFN-stimulated gene 15 functions as a critical antiviral molecule against influenza, herpes, and Sindbis viruses
    Deborah J Lenschow
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 104:1371-6. 2007
    ..increased susceptibility to both herpes simplex virus type 1 and murine gammaherpesvirus 68 infection and to Sindbis virus infection...
  47. ncbi Single and multiple deletions in the transmembrane domain of the Sindbis virus E2 glycoprotein identify a region critical for normal virus growth
    Christopher B Whitehurst
    Department of Molecular and Structural Biochemistry, North Carolina State University, Raleigh, 128 Polk Hall, NC 27695, USA
    Virology 347:199-207. 2006
    b>Sindbis virus is composed of two nested T = 4 icosahedral protein shells containing 240 copies each of three structural proteins: E1, E2, and Capsid in a 1:1:1 stoichiometric ratio...
  48. ncbi [Molecular basis of one-way serological reaction between SINV and XJ-160 virus]
    Li Hua Wang
    Department of Viral Encephalitis, Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention IVDC, China CDC and State Key Laboratory for Infectious Disease Prevention and Control SKLID, Beijing 100052, China
    Bing Du Xue Bao 26:228-33. 2010
    ..Our study identified the SINE2 gene was the determined gene for one way serological reaction between XJ-160 virus and SINV, and this research laid the foundation for further analysis of the genomic structure and function of SINV...
  49. ncbi Sindbis virus vectors for expression in animal cells
    H V Huang
    Department of Molecular Microbiology, Washington University School of Medicine, Box 8230, 660 South Euclid Avenue, St Louis, MO 63110 1093, USA
    Curr Opin Biotechnol 7:531-5. 1996
    b>Sindbis virus and other alphavirus gene expression vectors have recently been used to express and study the functions of proteins and RNA, to evaluate classical vaccine and novel antiviral approaches, and for nucleic acid immunization...
  50. ncbi Sindbis virus replicon particles encoding calreticulin linked to a tumor antigen generate long-term tumor-specific immunity
    W-F Cheng
    Department of Obstetrics and Gynecology, National Taiwan University Hospital, Taipei
    Cancer Gene Ther 13:873-85. 2006
    ..We concluded that the CRT strategy used in the context of SIN replicon particles facilitated the generation of a highly effective vaccine for cancer prophylaxis and immunotherapy...
  51. ncbi Recombination-ready Sindbis replicon expression vectors for transgene expression
    Brian J Geiss
    Arthropod Borne and Infectious Diseases Laboratory, Department of Molecular Biology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523, USA
    Virol J 4:112. 2007
    ....
  52. ncbi The 3' untranslated region of sindbis virus represses deadenylation of viral transcripts in mosquito and Mammalian cells
    Nicole L Garneau
    Colorado State University, Department of Microbiology, Immunology and Pathology, 1682 Campus Delivery, Fort Collins, CO 80523 1682, USA
    J Virol 82:880-92. 2008
    The positive-sense transcripts of Sindbis virus (SINV) resemble cellular mRNAs in that they possess a 5' cap and a 3' poly(A) tail...
  53. ncbi Contribution of T cells to mortality in neurovirulent Sindbis virus encephalomyelitis
    Jennifer F Rowell
    W. Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, 615 N. Wolfe Street, Baltimore, MD 21205, USA
    J Neuroimmunol 127:106-14. 2002
    Intranasal inoculation of C57BL/6 mice with a neurovirulent strain of Sindbis virus (SV) results in fatal encephalomyelitis...
  54. ncbi Structural and functional analyses of stem-loop 1 of the Sindbis virus genome
    David G Nickens
    Department of Biology, Indiana University, 1001 E Third Street, Bloomington, IN 47405, USA
    Virology 370:158-72. 2008
    Alphavirus genome function is controlled by elements at both the 5' and 3' ends. The 5' 220 nt of the Sindbis virus genome is predicted to consist of four stem-loop structures the first of which has been demonstrated to be required for ..
  55. ncbi Random insertion mutagenesis of sindbis virus nonstructural protein 2 and selection of variants incapable of downregulating cellular transcription
    Ilya Frolov
    Department of Microbiology, University of Alabama at Birmingham, 1530 Third Avenue South, BBRB 373 Box 3 Birmingham, AL 53294 2170, USA
    J Virol 83:9031-44. 2009
    b>Sindbis virus nonstructural protein 2 (SINV nsP2) is an important determinant of virus pathogenesis and downregulation of virus-induced cell response...
  56. ncbi Non-pathogenic Sindbis virus causes hemorrhagic fever in the absence of alpha/beta and gamma interferons
    Kate D Ryman
    Center for Molecular and Tumor Virology, Louisiana State University Health Sciences Center, Shreveport, LA 71130 3932, USA
    Virology 368:273-85. 2007
    ..We examined the contribution of IFNgamma to the protection of adult mice from Sindbis virus (SB)-induced disease by comparing subcutaneous infection of mice lacking receptors for either IFNalpha/beta (..
  57. ncbi Noncytolytic clearance of sindbis virus infection from neurons by gamma interferon is dependent on Jak/STAT signaling
    Rebeca Burdeinick-Kerr
    W Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USA
    J Virol 83:3429-35. 2009
    The alphavirus Sindbis virus (SINV) causes encephalomyelitis in mice by infecting neurons of the brain and spinal cord. The outcome is age dependent. Young animals develop fatal disease, while older animals recover from infection...
  58. ncbi An attenuating mutation in nsP1 of the Sindbis-group virus S.A.AR86 accelerates nonstructural protein processing and up-regulates viral 26S RNA synthesis
    Mark T Heise
    Department of Microbiology and Immunology, The University of North Carolina at Chapel Hill, 27599, USA
    J Virol 77:1149-56. 2003
    ..A.AR86 for adult mouse neurovirulence, while introduction of Thr at position 538 in a nonneurovirulent Sindbis virus background confers increased neurovirulence (M. T. Heise et al., J. Virol. 74:4207-4213, 2000)...
  59. ncbi Glycoprotein is enough for sindbis virus-derived DNA vector to express heterogenous genes
    Wuyang Zhu
    State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Viral Disease Control and Prevention, Chinese Center for Viral Disease Control and Prevention, Beijing 100052, China
    Virol J 8:344. 2011
    ..investigate the necessity and potential application of structural genes for expressing heterogenous genes from Sindbis virus-derived vector, the DNA-based expression vector pVaXJ was constructed by placing the recombinant genome of ..
  60. ncbi Dual mechanism for the translation of subgenomic mRNA from Sindbis virus in infected and uninfected cells
    Miguel Angel Sanz
    Centro de Biologia Molecular Severo Ochoa CSIC UAM, Universidad Autonoma de Madrid, Cantoblanco, Madrid, Spain
    PLoS ONE 4:e4772. 2009
    Infection of BHK cells by Sindbis virus (SV) gives rise to a profound inhibition of cellular protein synthesis, whereas translation of viral subgenomic mRNA that encodes viral structural proteins, continues for hours...
  61. ncbi Mutations in the endodomain of Sindbis virus glycoprotein E2 define sequences critical for virus assembly
    John West
    Department of Molecular and Structural Biochemistry, North Carolina State University, Campus Box 7622, Raleigh, North Carolina 27695-7622, USA
    J Virol 80:4458-68. 2006
    Envelopment of Sindbis virus at the plasma membrane is a multistep process in which an initial step is the association of the E2 protein via a cytoplasmic endodomain with the preassembled nucleocapsid...
  62. ncbi Deletions in the transmembrane domain of a sindbis virus glycoprotein alter virus infectivity, stability, and host range
    Raquel Hernandez
    Department of Molecular and Structural Biochemistry, North Carolina State University, Raleigh, North Carolina 27695, USA
    J Virol 77:12710-9. 2003
    ..We also found that membrane composition effects protein-protein and protein-membrane interactions during virus assembly...
  63. ncbi Rapid activation of poly(ADP-ribose) polymerase contributes to Sindbis virus and staurosporine-induced apoptotic cell death
    Jennifer L Nargi-Aizenman
    W. Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205, USA
    Virology 293:164-71. 2002
    ..PARP-1(-/-)) mice, and a mouse neuroblastoma cell line (N18), the role that poly(ADP-ribosyl)ation plays in Sindbis virus (SV)-induced apoptosis was examined...
  64. ncbi The RNA interference pathway affects midgut infection- and escape barriers for Sindbis virus in Aedes aegypti
    Cynthia C H Khoo
    Arthropod Borne and Infectious Diseases Laboratory, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA
    BMC Microbiol 10:130. 2010
    ..b>Sindbis virus (SINV; family: Togaviridae, genus: Alphavirus) is an arbovirus that infects Ae. aegypti in the laboratory...
  65. ncbi Oncolytic viral therapy for cervical and ovarian cancer cells by Sindbis virus AR339 strain
    Youichi Unno
    Department of Reproductive Medicine, Graduate School of Medicine, Chiba University, Inohana, Chiba, Japan
    Clin Cancer Res 11:4553-60. 2005
    Recently, the application of replication-competent viruses has been studied as anticancer agents. Sindbis virus (SIN) is an RNA virus that belongs to the Alphavirus genus in the Togaviridae virus family...
  66. ncbi The role of CD8(+) T cells and major histocompatibility complex class I expression in the central nervous system of mice infected with neurovirulent Sindbis virus
    T Kimura
    W Harry Feinstone Department of Molecular Microbiology and Immunology, School of Hygiene and Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
    J Virol 74:6117-25. 2000
    ..the role of CD8(+) T cells infiltrating the neural parenchyma during encephalitis induced by neurovirulent Sindbis virus (NSV)...
  67. ncbi Different types of nsP3-containing protein complexes in Sindbis virus-infected cells
    Rodion Gorchakov
    Department of Microbiology and Immunology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 1019, USA
    J Virol 82:10088-101. 2008
    ..The results of our study suggest that Sindbis virus (SINV) infection in BHK-21 cells leads to the formation of at least two types of nsP3-containing complexes, ..
  68. ncbi Structural localization of the E3 glycoprotein in attenuated Sindbis virus mutants
    A M Paredes
    National Center for Macromolecular Imaging, Verna and Marrs McLean Department of Biochemistry, Baylor College of Medicine, Houston, Texas 77030, USA
    J Virol 72:1534-41. 1998
    We have determined the three-dimensional structures of the wild-type Sindbis virus and two of its mutants that retain the E3 sequence within PE2...
  69. ncbi Restricted tissue tropism and acquired resistance to Sindbis viral vector expression in the absence of innate and adaptive immunity
    J C Tseng
    NYU Cancer Institute, Department of Pathology, NYU Gene Therapy Center, NYU School of Medicine, New York University, New York, NY, USA
    Gene Ther 14:1166-74. 2007
    ..Thus it appears that in vivo, in contrast to the ready transduction of tumor cells, transduction of normal cells by replication-defective Sindbis vector is limited, possibly by a novel mechanism...
  70. ncbi Pro-inflammatory response resulting from sindbis virus infection of human macrophages: implications for the pathogenesis of viral arthritis
    Iranaia Assunção-Miranda
    Program of Structural Biology, Institute of Medical Biochemistry, Federal University of Rio de Janeiro, RJ, Brazil
    J Med Virol 82:164-74. 2010
    ..b>Sindbis virus (SinV), a member of the Alphavirus genus, is the most widely distributed of all known arboviruses...
  71. ncbi Lentiviral vector retargeting to P-glycoprotein on metastatic melanoma through intravenous injection
    Kouki Morizono
    Department of Microbiology, Immunology and Molecular Genetics, University of California, 10833 Le Conte Avenue, Los Angeles, California 90095, USA
    Nat Med 11:346-52. 2005
    ..in a living animal through intravenous injection of a lentiviral vector pseudotyped with a modified chimeric Sindbis virus envelope (termed m168)...
  72. ncbi Genetic determinants of Sindbis virus strain TR339 affecting midgut infection in the mosquito Aedes aegypti
    Dennis J Pierro
    Arthropod Borne and Infectious Disease Laboratory, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA
    J Gen Virol 88:1545-54. 2007
    ..The Sindbis virus (SINV) strain TR339 efficiently infects Aedes aegypti MEC but the SINV strain TE/5'2J poorly infects MEC...
  73. ncbi The use of a double subgenomic Sindbis virus expression system to study mosquito gene function: effects of antisense nucleotide number and duration of viral infection on gene silencing efficiency
    D Tamang
    Department of Parasitology, National Yang-Ming University, Shih-Pai, Taipei, Taiwan
    Insect Mol Biol 13:595-602. 2004
    ....
  74. ncbi Sindbis virus vectors designed to express a foreign protein as a cleavable component of the viral structural polyprotein
    John M Thomas
    Department of Biology, The University of Texas at San Antonio, San Antonio, Texas 78249, USA
    J Virol 77:5598-606. 2003
    ..the 2A protease of foot-and-mouth disease virus and then inserted in frame between the capsid and E3 genes of Sindbis virus. During replication, the 2A fusion protein is synthesized as a component of the viral structural polyprotein ..
  75. ncbi Vaccination with a Sindbis virus-based DNA vaccine expressing antigen 85B induces protective immunity against Mycobacterium tuberculosis
    Steven C Derrick
    Laboratory of Mycobacterial Diseases and Cellular Immunology, Building 29 Room 511, CBER FDA, 29 Lincoln Dr, Bethesda, MD 20892, USA
    Infect Immun 73:7727-35. 2005
    To improve DNA vaccination against Mycobacterium tuberculosis, we evaluated the effectiveness of a Sindbis virus-based DNA construct expressing the tuberculosis antigen 85B (Sin85B)...
  76. ncbi Suppression of RNA interference increases alphavirus replication and virus-associated mortality in Aedes aegypti mosquitoes
    Chris M Cirimotich
    Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA
    BMC Microbiol 9:49. 2009
    ..The goal of this study was to use a recombinant Sindbis virus (SINV; family Togaviridae; genus Alphavirus) that expresses B2 protein of Flock House virus (FHV; family ..
  77. ncbi Functional characterization of the Sindbis virus E2 glycoprotein by transposon linker-insertion mutagenesis
    Chanakha K Navaratnarajah
    Department of Biological Sciences, Purdue University, 915 W State Street, West Lafayette, IN 47907 2054, USA
    Virology 363:134-47. 2007
    ..of mutants, containing 19 amino acid insertions in the E2 glycoprotein sequence of the prototype alphavirus, Sindbis virus (SINV), was generated...
  78. ncbi Identification of the amino acid sequence in Sindbis virus nsP4 that binds to the promoter for the synthesis of the subgenomic RNA
    Mei-Ling Li
    Department of Molecular Genetics, Microbiology, and Immunology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    Proc Natl Acad Sci U S A 101:9429-34. 2004
    A gel mobility-shift assay was used to demonstrate the binding of the Sindbis virus transcriptase to the promoter for the synthesis of subgenomic (SG) RNA...
  79. ncbi Synthesis of genomic and subgenomic RNA in mosquito cells infected with two Sindbis virus nsP4 mutants: influence of intracellular nucleoside triphosphate concentrations
    Mei Ling Li
    Department of Molecular Genetics, Microbiology and Immunology, UMDNJ Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    J Virol 82:6880-8. 2008
    Cells infected with Sindbis virus (SV) make two positive-strand RNAs, a genomic-length RNA (G) RNA and a subgenomic (SG) RNA...
  80. ncbi Serological evidence of West Nile virus, Usutu virus and Sindbis virus infection of birds in the UK
    Alan Buckley
    Centre for Ecology and Hydrology Oxford, Institute of Virology and Environmental Microbiology, Mansfield Road, Oxford OX1 3SR, UK
    J Gen Virol 84:2807-17. 2003
    ..b>Sindbis virus, a pathogenic alphavirus that causes arthritis, is widespread throughout Africa, Europe, Asia and Australia, ..
  81. ncbi Heterogeneous nuclear ribonuclear protein K interacts with Sindbis virus nonstructural proteins and viral subgenomic mRNA
    Andrew J Burnham
    Department of Biology, Indiana University, 1001 E Third Street, Bloomington, IN 47405, USA
    Virology 367:212-21. 2007
    ..enriched in cytoplasmic membrane fractions containing viral RNA synthetic complexes following infection with Sindbis virus. Our studies demonstrated the following: (i) the host protein hnRNP K is enriched in cytoplasmic membrane ..
  82. ncbi Photoinactivation of sindbis virus infectivity without inhibition of membrane fusion
    Wor Thongthai
    Department of Physics, North Carolina State University, Raleigh, USA
    Photochem Photobiol 85:801-6. 2009
    ..Here we show that photobleaching of Sindbis virus labeled with the membrane localized dye, R18 (octadecyl rhodamine B) causes a dramatic loss of infectivity ..
  83. ncbi Using sindbis viral vectors for specific detection and suppression of advanced ovarian cancer in animal models
    Jen-Chieh Tseng
    New York University Cancer Institute, the Rita J. and Stanley H. Kaplan Comprehensive Cancer Center, and the New York University Gene Therapy Center, New York University School of Medicine, New York, New York 10016, USA
    Cancer Res 64:6684-92. 2004
    ..b>Sindbis virus is known to infect mammalian cells using the Mr 67,000 laminin receptor...
  84. ncbi Deletions in the putative cell receptor-binding domain of Sindbis virus strain MRE16 E2 glycoprotein reduce midgut infectivity in Aedes aegypti
    Kevin M Myles
    Arthropod-Borne and Infectious Diseases Laboratory, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado 80526, USA
    J Virol 77:8872-81. 2003
    The Sindbis virus (Alphavirus; Togaviridae) strain MRE16 efficiently infects Aedes aegypti mosquitoes that ingest a blood meal containing 8 to 9 log(10) PFU of virus/ml...
  85. ncbi Infection of human dendritic cells by a sindbis virus replicon vector is determined by a single amino acid substitution in the E2 glycoprotein
    J P Gardner
    Vaccines and Gene Therapy, Chiron Corporation, Emeryville, California 94608, USA
    J Virol 74:11849-57. 2000
    ..Toward this goal, we derived variants of the prototype alphavirus, Sindbis virus (SIN), with differential abilities to infect human dendritic cells...
  86. ncbi Alphavirus minus-strand synthesis and persistence in mouse embryo fibroblasts derived from mice lacking RNase L and protein kinase R
    Dorothea L Sawicki
    Department of Microbiology and Immunology, Medical College of Ohio, Toledo, Ohio 43614, USA
    J Virol 77:1801-11. 2003
    ....
  87. ncbi In vivo addition of poly(A) tail and AU-rich sequences to the 3' terminus of the Sindbis virus RNA genome: a novel 3'-end repair pathway
    R Raju
    Department of Microbiology, School of Medicine, Meharry Medical College, Nashville, Tennessee 37208, USA
    J Virol 73:2410-9. 1999
    Alphaviruses are mosquito-transmitted RNA viruses that cause important diseases in both humans and livestock. Sindbis virus (SIN), the type species of the alphavirus genus, carries a 11...
  88. ncbi Infection of neonatal mice with sindbis virus results in a systemic inflammatory response syndrome
    W B Klimstra
    Department of Microbiology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27599 7290, USA
    J Virol 73:10387-98. 1999
    ..This report suggests that this is the case with Sindbis virus strain AR339...
  89. ncbi Antibody-directed targeting of retroviral vectors via cell surface antigens
    K Morizono
    Department of Microbiology, Immunology and Molecular Genetics, UCLA School of Medicine, Los Angeles, California 90095, USA
    J Virol 75:8016-20. 2001
    ..We find that the envelope of the alphavirus Sindbis virus can pseudotype human immunodeficiency virus type 1- and murine leukemia virus-based retroviral vectors...
  90. ncbi Bioprocess applications of a Sindbis virus-based temperature-inducible expression system
    M Boorsma
    Cytos Biotechnology AG, Wagistrasse 21, CH-8952, Zurich-Schlieren, Switzerland
    Biotechnol Bioeng 79:602-9. 2002
    ..Here, we describe bioprocess applications of the pCytTS temperature-regulatable Sindbis virus replicon-based expression system...
  91. ncbi Gamma interferon-dependent, noncytolytic clearance of sindbis virus infection from neurons in vitro
    Rebeca Burdeinick-Kerr
    W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, Maryland 21205, USA
    J Virol 79:5374-85. 2005
    ..an in vitro cell culture system that will allow the study of mechanisms of IFN-gamma-mediated control of Sindbis virus (SINV) replication in neurons, we have characterized the susceptibility to SINV infection and IFN-gamma ..
  92. ncbi Targeting Sindbis virus-based vectors to Fc receptor-positive cell types
    William B Klimstra
    Department of Microbiology and Immunology, Center for Molecular and Tumor Virology, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA
    Virology 338:9-21. 2005
    ..Specifically, ADE did not occur with FcgammaR-negative cells, did not require active complement proteins, and did not occur on FcgammaR-positive murine cell lines when virions were bound by murine IgG-derived F(ab')2 fragments...
  93. ncbi Gamma-retroviral vectors enveloped with an antibody and an engineered fusogenic protein achieved antigen-specific targeting
    Haiguang Yang
    Mork Family Department of Chemical Engineering and Materials Science, University of Southern California, Los Angeles, California 90089, USA
    Biotechnol Bioeng 101:357-68. 2008
    ..An anti-CD20 antibody and a fusogenic protein derived from Sindbis virus glycoprotein could be efficiently co-displayed on the surface of viral vectors...
  94. ncbi Requirements at the 3' end of the sindbis virus genome for efficient synthesis of minus-strand RNA
    Richard W Hardy
    Department of Biology, Indiana University, 1001 E Third St, Bloomington, IN 47405, USA
    J Virol 79:4630-9. 2005
    The 3'-untranslated region of the Sindbis virus genome is 0.3 kb in length with a 19-nucleotide conserved sequence element (3' CSE) immediately preceding the 3'-poly(A) tail...
  95. ncbi Sindbis virus-induced silencing of dengue viruses in mosquitoes
    Z N Adelman
    Arthropod-borne and Infectious Diseases Laboratory (AIDL, Department of Microbiology, Colorado State University, Fort Collins, CO 80523, USA
    Insect Mol Biol 10:265-73. 2001
    ....
  96. ncbi Inhibition of alphavirus infection in cell culture and in mice with antisense morpholino oligomers
    Slobodan Paessler
    Department of Pathology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 1019, USA
    Virology 376:357-70. 2008
    ..b>Sindbis virus (SINV) has low pathogenicity in humans and is regularly utilized as a model alphavirus...
  97. ncbi Seco-pregnane steroids target the subgenomic RNA of alphavirus-like RNA viruses
    Yanmei Li
    State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, China
    Proc Natl Acad Sci U S A 104:8083-8. 2007
    ..positive-strand RNA viruses including plant-infecting tobacco mosaic virus (TMV) and animal-infecting Sindbis virus (SINV), eastern equine encephalitis virus, and Getah virus, but not to other RNA or DNA viruses, yet they were ..
  98. ncbi Aedes aegypti salivary gland extracts modulate anti-viral and TH1/TH2 cytokine responses to sindbis virus infection
    Bradley S Schneider
    Department of Pathology, University of Texas Medical Branch, Galveston, Texas 77555-0609, USA
    Viral Immunol 17:565-73. 2004
    ..In this study, intradermal inoculations of Aedes aegypti salivary gland extract (SGE) and Sindbis virus (SINV) were used to investigate the effect of mosquito feeding on the vertebrate immune response to infection ..
  99. ncbi Construction and applications of yellow fever virus replicons
    Christopher T Jones
    Department of Biological Sciences, Purdue University, 915 W. State Street, West Lafayette, IN 47907-2054, USA
    Virology 331:247-59. 2005
    ....
  100. ncbi Enhancement of sindbis virus self-replicating RNA vaccine potency by linkage of herpes simplex virus type 1 VP22 protein to antigen
    W F Cheng
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    J Virol 75:2368-76. 2001
    ..We therefore created a novel fusion of VP22 with a model tumor antigen, human papillomavirus type 16 E7, in a Sindbis virus RNA replicon vector...
  101. ncbi Sindbis virus with a tricomponent genome
    Rafik Fayzulin
    Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas 77555-1019, USA
    J Virol 79:637-43. 2005
    We established a system for propagation of Sindbis virus (SIN)-based replicons in tissue culture in the form of a tricomponent genome virus...

Research Grants76

  1. MR and BL Tracking of Stem/Progenitor Cells in the CNS
    Jeff W Bulte; Fiscal Year: 2010
    ..e., a ricin-induced model as a localized, monophasic and a neurotropic Sindbis virus (NSV)-induced as a global, inflammatory disease model...
  2. Mechanisms of apoptosis in the central nervous system
    Kenneth Tyler; Fiscal Year: 2009
    ..activation of these pathways in the brain following infection with other encephalitic viruses, including JEV, Sindbis virus (SINV), and Venezualen equine encephalitis virus (VEEV). OBJECTIVE 2...
  3. A Sindbis virus-based Vaccine Against RVFV Infection
    Ilya Frolov; Fiscal Year: 2006
    ..We propose to develop a prototype recombinant vaccine against RVFV infection based on Sindbis virus replicons expressing structural proteins of RVFV...
  4. Characterization of the La Crosse Virus glycoprotein fusion peptide
    Francisco Gonzalez Scarano; Fiscal Year: 2010
    ..similarities between LACV Gc amino acid region 970-1350 and the E1 fusion protein of two alphaviruses: Sindbis virus and Semliki Forrest virus (SFV)...
  5. Characterization of the La Crosse Virus glycoprotein fusion peptide
    Francisco Gonzalez Scarano; Fiscal Year: 2009
    ..similarities between LACV Gc amino acid region 970-1350 and the E1 fusion protein of two alphaviruses: Sindbis virus and Semliki Forrest virus (SFV)...
  6. Replicon-based screening for inhibitors of alphaviruses
    PAUL OLIVO; Fiscal Year: 2005
    ..b>Sindbis virus and VEEV are prototypic alphaviruses that have been extensively used as vectors for expression of foreign ..
  7. A Viral Vector for Gene Expression in Insects
    Ranjit Dasgupta; Fiscal Year: 2007
    ..Vectors derived from Sindbis virus (SIN) have proven to be very useful in this type of research and few other viral vectors are under development...
  8. A Viral Vector for Gene Expression in Insects
    Ranjit Dasgupta; Fiscal Year: 2003
    ..Viruses, such as Sindbis virus, developed for transient gene expression and gene silencing in insects have proven useful in this type of ..
  9. Regulation of Sindbis Virus Subgenomic RNA Synthesis
    Victor Stollar; Fiscal Year: 2010
    b>Sindbis virus, (SV) one of the simplest, enveloped RNA viruses, is the prototype virus of the family Togaviridae, genus alphavirus. It is transmitted to its vertebrate hosts by mosquitoes...
  10. Regulation of Sindbis Virus Subgenomic RNA Synthesis
    Victor Stollar; Fiscal Year: 2007
    b>Sindbis virus, (SV) one of the simplest, enveloped RNA viruses, is the prototype virus of the family Togaviridae, genus alphavirus. It is transmitted to its vertebrate hosts by mosquitoes...
  11. Alphavirus Replicons for Mucosal HIV Vaccines
    Michael Vajdy; Fiscal Year: 2002
    ..We recently discovered that our Sindbis virus-based non-replicating particles expressing HIV-1 gag (SIN-gag), which had been successfully used for ..
  12. RNA REPAIR AND RECOMBINATION--AN ALPHAVIRUS MODEL
    RAMASAMY RAJU; Fiscal Year: 2001
    ..b>Sindbis virus (SIN), the subject of this proposal, is a mosquito-transmitted human alphavirus...
  13. Efficacy of the antiviral state versus Sindbis and Venezuelan equine encephalitis
    William B Klimstra; Fiscal Year: 2010
    ..virus (VEEV), is much more resistant to the activity of the antiviral state than the human-avirulent Sindbis virus (SINV) and that the virulence of the viruses in animal models is largely reflective of these differences...
  14. TOGAVIRUS REPLICATION OF STRATEGIES AND EVOLUTION
    James Strauss; Fiscal Year: 1999
    ..The alphaviruses appear to be able to use more than one receptor and the receptor for Sindbis virus appears to be different in birds and mammals...
  15. Nucleotide Pools and the Replication of Sindbis Virus
    Victor Stollar; Fiscal Year: 2003
    ..b>Sindbis virus (SV), a mosquito-transmitted arbovirus, and the prototype virus of the family Togaviridae, genus aiphavirus, ..
  16. Interaction of Sindbis Virus with Cellular Processes
    Ilya Frolov; Fiscal Year: 2009
    ..Identification of the cellular proteins that are essential for virus growth will lead to development of new antiviral therapeutic strategies. ..
  17. IMMUNE RESPONSE OF MOSQUITOES TO FILARIAL WORMS
    Bruce Christensen; Fiscal Year: 2005
    ..Finally, the PI will engineer double subgenomic Sindbis virus to express antisense RNA for these genes for use in knockout strategies in Ar. subalbatus...
  18. Protection of Mice From Lethal Alphavirus Encephalitis
    David N Irani; Fiscal Year: 2010
    ..S. Public Health Service given their potential use as bioterrorism agents. One alphavirus, Sindbis virus (SV), has been extensively studied in a murine model...
  19. MOLECULAR GENETICS OF SINDBIS VIRUS REPLICATION
    Charles Rice; Fiscal Year: 2005
    ..The experiments detailed in this proposal concern our current studies on Sindbis virus (SIN), type virus of the family Togaviridae...