chikungunya virus

Summary

Summary: A species of ALPHAVIRUS causing an acute dengue-like fever.

Top Publications

  1. ncbi Infection with chikungunya virus in Italy: an outbreak in a temperate region
    G Rezza
    Department of Infectious, Parasitic, and Immunomediated Diseases, Istituto Superiore di Sanita, Rome, Italy
    Lancet 370:1840-6. 2007
  2. ncbi Biology and pathogenesis of chikungunya virus
    Olivier Schwartz
    Institut Pasteur, 28 rue du Dr Roux, Paris 75724 Cedex 15, France
    Nat Rev Microbiol 8:491-500. 2010
  3. ncbi A single mutation in chikungunya virus affects vector specificity and epidemic potential
    Konstantin A Tsetsarkin
    Department of Pathology, University of Texas Medical Branch, Galveston, Texas, United States of America
    PLoS Pathog 3:e201. 2007
  4. ncbi Chikungunya disease in nonhuman primates involves long-term viral persistence in macrophages
    Karine Labadie
    CEA, Division of Immuno Virology Institute of Emerging Diseases and Innovative Therapies, Fontenay aux Roses, France
    J Clin Invest 120:894-906. 2010
  5. ncbi A mouse model for Chikungunya: young age and inefficient type-I interferon signaling are risk factors for severe disease
    Thérèse Couderc
    Groupe Microorganismes et Barrières de l Hôte, Institut Pasteur, Paris, France
    PLoS Pathog 4:e29. 2008
  6. ncbi Chikungunya, an epidemic arbovirosis
    Gilles Pialoux
    Hopital Tenon, Service des Maladies Infectieuses et Tropicales, Paris, France
    Lancet Infect Dis 7:319-27. 2007
  7. ncbi Re-emergence of Chikungunya virus in South-east Asia: virological evidence from Sri Lanka and Singapore
    H C Hapuarachchi
    National Environment Agency, Environmental Health Institute, Singapore
    J Gen Virol 91:1067-76. 2010
  8. ncbi Outbreak of chikungunya on Reunion Island: early clinical and laboratory features in 157 adult patients
    Gianandrea Borgherini
    Service de Pneumologie et Maladies Infectieuses, Groupe Hospitalier Sud Reunion, Saint Pierre, La Reunion, France
    Clin Infect Dis 44:1401-7. 2007
  9. ncbi Replication cycle of chikungunya: a re-emerging arbovirus
    Maxime Solignat
    Universite Montpellier 1, Centre d Etudes d Agents Pathogenes et Biotechnologies pour la Sante CPBS, Montpellier, France
    Virology 393:183-97. 2009
  10. ncbi Persistent chronic inflammation and infection by Chikungunya arthritogenic alphavirus in spite of a robust host immune response
    Jean Jacques Hoarau
    Biology Unit, Centre Hospitalier Régional Nord Félix Guyon and Cyclotron Réunion Océan Indien, Universite de la Reunion, St Denis, France
    J Immunol 184:5914-27. 2010

Research Grants

  1. Mechanisms of sylvatic dengue emergence
    Scott Weaver; Fiscal Year: 2009
  2. Mechanisms of sylvatic dengue emergence
    Scott C Weaver; Fiscal Year: 2010
  3. Antibody Based Therapeuticcs for Chikungunya Virus
    Michael S Diamond; Fiscal Year: 2010
  4. Arbovirus Evasion of Type I Interferon Induction
    Mark Heise; Fiscal Year: 2007
  5. Immune Evasion Mechanisms of Neurovirulent Alphaviruses
    Mark Heise; Fiscal Year: 2009
  6. Immune Evasion Mechanisms of Neurovirulent Alphaviruses
    Mark T Heise; Fiscal Year: 2011
  7. TOGAVIRUS TROPISM FOR BONES, JOINTS, AND CNS
    Mark Heise; Fiscal Year: 2004
  8. TOGAVIRUS TROPISM FOR BONES, JOINTS, AND CNS
    Mark T Heise; Fiscal Year: 2010
  9. TOGAVIRUS TROPISM FOR BONES, JOINTS, AND CNS
    Mark Heise; Fiscal Year: 2009
  10. TOGAVIRUS TROPISM FOR BONES, JOINTS, AND CNS
    Mark Heise; Fiscal Year: 2007

Detail Information

Publications219 found, 100 shown here

  1. ncbi Infection with chikungunya virus in Italy: an outbreak in a temperate region
    G Rezza
    Department of Infectious, Parasitic, and Immunomediated Diseases, Istituto Superiore di Sanita, Rome, Italy
    Lancet 370:1840-6. 2007
    b>Chikungunya virus (CHIKV), which is transmitted by Aedes spp mosquitoes, has recently caused several outbreaks on islands in the Indian Ocean and on the Indian subcontinent. We report on an outbreak in Italy.
  2. ncbi Biology and pathogenesis of chikungunya virus
    Olivier Schwartz
    Institut Pasteur, 28 rue du Dr Roux, Paris 75724 Cedex 15, France
    Nat Rev Microbiol 8:491-500. 2010
    b>Chikungunya virus (CHIKV) is a re-emerging mosquito-borne alphavirus responsible for a recent, unexpectedly severe epidemic in countries of the Indian Ocean region...
  3. ncbi A single mutation in chikungunya virus affects vector specificity and epidemic potential
    Konstantin A Tsetsarkin
    Department of Pathology, University of Texas Medical Branch, Galveston, Texas, United States of America
    PLoS Pathog 3:e201. 2007
    b>Chikungunya virus (CHIKV) is an emerging arbovirus associated with several recent large-scale epidemics...
  4. ncbi Chikungunya disease in nonhuman primates involves long-term viral persistence in macrophages
    Karine Labadie
    CEA, Division of Immuno Virology Institute of Emerging Diseases and Innovative Therapies, Fontenay aux Roses, France
    J Clin Invest 120:894-906. 2010
    b>Chikungunya virus (CHIKV) is a mosquito-borne alphavirus that induces in humans a disease characterized by fever, rash, and pain in muscles and joints...
  5. ncbi A mouse model for Chikungunya: young age and inefficient type-I interferon signaling are risk factors for severe disease
    Thérèse Couderc
    Groupe Microorganismes et Barrières de l Hôte, Institut Pasteur, Paris, France
    PLoS Pathog 4:e29. 2008
    b>Chikungunya virus (CHIKV) is a re-emerging arbovirus responsible for a massive outbreak currently afflicting the Indian Ocean region and India...
  6. ncbi Chikungunya, an epidemic arbovirosis
    Gilles Pialoux
    Hopital Tenon, Service des Maladies Infectieuses et Tropicales, Paris, France
    Lancet Infect Dis 7:319-27. 2007
    ..The virus was first isolated in 1953 in Tanzania. Chikungunya virus is a member of the genus Alphavirus and the family Togaviridae...
  7. ncbi Re-emergence of Chikungunya virus in South-east Asia: virological evidence from Sri Lanka and Singapore
    H C Hapuarachchi
    National Environment Agency, Environmental Health Institute, Singapore
    J Gen Virol 91:1067-76. 2010
    ..However, molecular epidemiological data to explain the recent spread and evolution of Chikungunya virus (CHIKV) in the Asian region are still limited...
  8. ncbi Outbreak of chikungunya on Reunion Island: early clinical and laboratory features in 157 adult patients
    Gianandrea Borgherini
    Service de Pneumologie et Maladies Infectieuses, Groupe Hospitalier Sud Reunion, Saint Pierre, La Reunion, France
    Clin Infect Dis 44:1401-7. 2007
    ..Chikungunya is a reemerging disease. In 2005-2006, a severe outbreak occurred on Reunion Island in the southwestern part of the Indian Ocean. Other islands in this area were affected during the same period...
  9. ncbi Replication cycle of chikungunya: a re-emerging arbovirus
    Maxime Solignat
    Universite Montpellier 1, Centre d Etudes d Agents Pathogenes et Biotechnologies pour la Sante CPBS, Montpellier, France
    Virology 393:183-97. 2009
    ..The 2005-2006 year unprecedented epidemics of chikungunya virus (CHIKV) in the French Reunion Island in the Indian Ocean, followed by several outbreaks in other parts of ..
  10. ncbi Persistent chronic inflammation and infection by Chikungunya arthritogenic alphavirus in spite of a robust host immune response
    Jean Jacques Hoarau
    Biology Unit, Centre Hospitalier Régional Nord Félix Guyon and Cyclotron Réunion Océan Indien, Universite de la Reunion, St Denis, France
    J Immunol 184:5914-27. 2010
    Alphaviruses, including Chikungunya virus (CHIKV), produce a transient illness in humans, but severe forms leading to chronic incapacitating arthralgia/arthritis have been reported by mechanisms largely ill-characterized...
  11. ncbi Chikungunya virus, southeastern France
    Marc Grandadam
    Institut Pasteur, Paris, France
    Emerg Infect Dis 17:910-3. 2011
    In September 2010, autochthonous transmission of chikungunya virus was recorded in southeastern France, where the Aedes albopictus mosquito vector is present...
  12. ncbi Chikungunya virus induces IPS-1-dependent innate immune activation and protein kinase R-independent translational shutoff
    Laura K White
    Oregon Health and Science University, Vaccine and Gene Therapy Institute, 505 NW 185th Ave, Portland, OR 97006, USA
    J Virol 85:606-20. 2011
    b>Chikungunya virus (CHIKV) is an arthritogenic mosquito-transmitted alphavirus that is undergoing reemergence in areas around the Indian Ocean...
  13. ncbi Glycoprotein organization of Chikungunya virus particles revealed by X-ray crystallography
    James E Voss
    Institut Pasteur, Departement de Virologie, Unité de Virologie Structurale, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    Nature 468:709-12. 2010
    b>Chikungunya virus (CHIKV) is an emerging mosquito-borne alphavirus that has caused widespread outbreaks of debilitating human disease in the past five years...
  14. ncbi A virus-like particle vaccine for epidemic Chikungunya virus protects nonhuman primates against infection
    Wataru Akahata
    Vaccine Research Center, National Institute of Allergy and Infectious Diseases, US National Institutes of Health, Bethesda, Maryland, USA
    Nat Med 16:334-8. 2010
    b>Chikungunya virus (CHIKV) has infected millions of people in Africa, Europe and Asia since this alphavirus reemerged from Kenya in 2004...
  15. ncbi Genome-scale phylogenetic analyses of chikungunya virus reveal independent emergences of recent epidemics and various evolutionary rates
    Sara M Volk
    University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555 0609
    J Virol 84:6497-504. 2010
    b>Chikungunya virus (CHIKV), a mosquito-borne alphavirus, has traditionally circulated in Africa and Asia, causing human febrile illness accompanied by severe, chronic joint pain...
  16. ncbi Two Chikungunya isolates from the outbreak of La Reunion (Indian Ocean) exhibit different patterns of infection in the mosquito, Aedes albopictus
    Marie Vazeille
    Département de Virologie Chikungunya program, Institut Pasteur, Paris, France
    PLoS ONE 2:e1168. 2007
    ..The implicated vector was Aedes albopictus. Here, we present the first study on the susceptibility of Ae. albopictus populations to sympatric CHIKV isolates from La Réunion Island and compare it to other virus/vector combinations...
  17. ncbi Impact of Chikungunya virus infection on health status and quality of life: a retrospective cohort study
    Man Koumba Soumahoro
    Universite Pierre et Marie Curie, Unité Mixte de Recherche en Santé 707, Paris, France
    PLoS ONE 4:e7800. 2009
    Persistent symptoms, mainly joint and muscular pain and depression, have been reported several months after Chikungunya virus (CHIKV) infection...
  18. ncbi Genome microevolution of chikungunya viruses causing the Indian Ocean outbreak
    Isabelle Schuffenecker
    Centre National de Référence des Arbovirus, Institut Pasteur, Lyon, France
    PLoS Med 3:e263. 2006
    A chikungunya virus outbreak of unprecedented magnitude is currently ongoing in Indian Ocean territories. In Réunion Island, this alphavirus has already infected about one-third of the human population...
  19. ncbi IL-1beta, IL-6, and RANTES as biomarkers of Chikungunya severity
    Lisa F P Ng
    Singapore Immunology Network, Agency for Science, Technology and Research, Singapore
    PLoS ONE 4:e4261. 2009
    Little is known about the immunopathogenesis of Chikungunya virus. Circulating levels of immune mediators and growth factors were analyzed from patients infected during the first Singaporean Chikungunya fever outbreak in early 2008 to ..
  20. ncbi [Aedes albopictus, vector of chikungunya and dengue viruses in Reunion Island: biology and control]
    H Delatte
    UR 016, IRD, BP 64501, 34394 Montpellier 5, France
    Parasite 15:3-13. 2008
    b>Chikungunya virus (CHIKV) and dengue virus (DENV) are mosquito-borne viruses transmitted by the Aedes genus. Dengue is considered as the most important arbovirus disease throughout the World...
  21. ncbi Estimating Chikungunya prevalence in La Réunion Island outbreak by serosurveys: two methods for two critical times of the epidemic
    Patrick Gerardin
    Centre d Investigation Clinique Epidémiologie Clinique de La Réunion, Institut National de la Sante et de la Recherche Medicale, Groupe Hospitalier Sud Reunion, Saint Pierre
    BMC Infect Dis 8:99. 2008
    b>Chikungunya virus (CHIKV) caused a major two-wave seventeen-month-long outbreak in La Réunion Island in 2005-2006...
  22. ncbi Concurrent chikungunya and dengue virus infections during simultaneous outbreaks, Gabon, 2007
    Eric M Leroy
    Centre International de Recherches Medicales de Franceville, Franceville, Gabon
    Emerg Infect Dis 15:591-3. 2009
    ..Chikungunya or dengue-2 virus infections were identified in 321 patients; 8 patients had documented co-infections. Aedes albopictus was identified as the principal vector for the transmission of both viruses...
  23. ncbi Multidisciplinary prospective study of mother-to-child chikungunya virus infections on the island of La Réunion
    Patrick Gerardin
    Neonatal and Pediatric Intensive Care Unit, pôle Mère Enfant, Groupe Hospitalier Sud Reunion, Saint Pierre, La Reunion, France
    PLoS Med 5:e60. 2008
    An outbreak of chikungunya virus affected over one-third of the population of La Réunion Island between March 2005 and December 2006...
  24. ncbi Chikungunya virus mobilizes the apoptotic machinery to invade host cell defenses
    Pascale Krejbich-Trotot
    GRI IRG Immunopathology and Infection Research Grouping, University of La Réunion, CYROI, 2 rue Maxime Rivière, 97491, Ste Clotilde, Reunion
    FASEB J 25:314-25. 2011
    b>Chikungunya virus (CHIKV) surprised medical workers by a massive outbreak in the Indian Ocean region, reaching Europe in 2007, with exceptional pathologies in infants and elderly patients...
  25. ncbi Chikungunya fever: an epidemiological review of a re-emerging infectious disease
    J Erin Staples
    Arboviral Diseases Branch, Division of Vector Borne Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado 80521, USA
    Clin Infect Dis 49:942-8. 2009
    ..The disease is caused by Chikungunya virus (CHIKV), an arthropod-borne virus that is transmitted to humans primarily via the bite of an infected ..
  26. ncbi Persistent arthralgia associated with chikungunya virus: a study of 88 adult patients on reunion island
    Gianandrea Borgherini
    Service de Pneumologie et Maladies Infectieuses, Groupe Hospitalier Sud Reunion, Saint Pierre, La Reunion, France
    Clin Infect Dis 47:469-75. 2008
    An outbreak of chikungunya virus infection occurred on Reunion Island during the period 2005-2006. Persistent arthralgia after chikungunya virus infection has been reported, but few studies have treated this aspect of the disease.
  27. ncbi Chikungunya: an emerging and spreading arthropod-borne viral disease
    Francesca Cavrini
    The Emilia Romagna Regional Reference Centre for Microbiological Emergencies CRREM Unit of Microbiology, St Orsola Malpighi Hospital, University of Bologna, Bologna, Italy
    J Infect Dev Ctries 3:744-52. 2009
    ..Currently, Chikungunya is spreading in Southeast Asian aspects, clinical pictures, diagnosis and treatment of the disease caused by Chikungunya virus.
  28. ncbi International diagnostic accuracy study for the serological detection of chikungunya virus infection
    M Niedrig
    Centre for Biological Safety ZBS 1, Robert Koch Institut, Berlin, Germany
    Clin Microbiol Infect 15:880-4. 2009
    External quality assurance for serological detection of chikungunya virus infection was performed to assess the diagnostic quality of expert laboratories...
  29. ncbi Understanding the alphaviruses: recent research on important emerging pathogens and progress towards their control
    E A Gould
    Institut de Recherche pour le Développement UMR190 Unité des Virus Emergents, Universite de la Mediterranee, Marseille, France
    Antiviral Res 87:111-24. 2010
    ..their classification, epidemiology and evolutionary history and the expanding geographic distribution of Chikungunya virus, we review progress in understanding the structure and function of alphavirus replicative enzymes achieved ..
  30. ncbi Chikungunya virus nonstructural protein 2 inhibits type I/II interferon-stimulated JAK-STAT signaling
    Jelke J Fros
    Laboratory of Virology, Wageningen University, Droevendaalsesteeg 1, 6708 PB Wageningen, Netherlands
    J Virol 84:10877-87. 2010
    b>Chikungunya virus (CHIKV) is an emerging human pathogen transmitted by mosquitoes...
  31. ncbi Chikungunya virus arthritis in adult wild-type mice
    Joy Gardner
    Queensland Institute of Medical Research, Australian Centre for International and Tropical Health, Brisbane, Australia
    J Virol 84:8021-32. 2010
    b>Chikungunya virus is a mosquito-borne arthrogenic alphavirus that has recently reemerged to produce the largest epidemic ever documented for this virus...
  32. ncbi Active infection of human blood monocytes by Chikungunya virus triggers an innate immune response
    Zhisheng Her
    Singapore Immunology Network, Agency for Science, Technology and Research, Biopolis, Singapore
    J Immunol 184:5903-13. 2010
    b>Chikungunya virus (CHIKV) is an alphavirus that causes chronic and incapacitating arthralgia in humans. To date, interactions between the immune system and the different stages of the virus life cycle remain poorly defined...
  33. ncbi An animal model for studying the pathogenesis of chikungunya virus infection
    Sarah A Ziegler
    Department of Pathology and Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, Texas 77555 0609, USA
    Am J Trop Med Hyg 79:133-9. 2008
    Newborn and 14-day-old mice inoculated subcutaneously with chikungunya virus (CHIKV) developed lethargy, difficulty walking, dragging of hind limbs, and reduced weight gain within 7-10 days after infection (PI)...
  34. ncbi Chikungunya virus, Cameroon, 2006
    Christophe N Peyrefitte
    Institut de Medecine Tropicale du Service de Sante des Armees, Marseille, France
    Emerg Infect Dis 13:768-71. 2007
    We report the isolation of chikungunya virus from a patient during an outbreak of a denguelike syndrome in Cameroon in 2006...
  35. ncbi Post-epidemic Chikungunya disease on Reunion Island: course of rheumatic manifestations and associated factors over a 15-month period
    Daouda Sissoko
    Institut de Veille Sanitaire, Cellule Interrégionale d Epidémiologie Réunion Mayotte, Direction Régionale des Affaires Sanitaires et Sociales, Saint Denis, La Reunion, France
    PLoS Negl Trop Dis 3:e389. 2009
    Although the acute manifestations of Chikungunya virus (CHIKV) illness are well-documented, few data exist about the long-term rheumatic outcomes of CHIKV-infected patients...
  36. ncbi Chikungunya: a bending reality
    Zhisheng Her
    Singapore Immunology Network, Agency for Science, Technology and Research, Immunos, Singapore
    Microbes Infect 11:1165-76. 2009
    Chikungunya fever is an acute illness caused by the arbovirus Chikungunya virus. The virus is transmitted primarily in a sylvatic cycle involving the Aedes mosquitoes...
  37. ncbi Tracking epidemic Chikungunya virus into the Indian Ocean from East Africa
    M Kariuki Njenga
    International Emerging Infections Program Kenya, Centers for Disease Control and Prevention, Nairobi, Kenya
    J Gen Virol 89:2754-60. 2008
    The largest documented outbreak of Chikungunya virus (CHIKV) disease occurred in the Indian Ocean islands and India during 2004-2007...
  38. ncbi Appearance of E1: A226V mutant Chikungunya virus in Coastal Karnataka, India during 2008 outbreak
    S R Santhosh
    Division of Virology, Defence R and D Establishment DRDE, Jhansi Road, Gwalior, MP, PIN 474 002, India
    Virol J 6:172. 2009
    ..isolation, RT-PCR and genome sequencing revealed the presence and continued circulation of A226V mutant Chikungunya virus. The appearance of this mutant virus was found to be associated with higher prevalence of vector Aedes ..
  39. ncbi Comparative full genome analysis revealed E1: A226V shift in 2007 Indian Chikungunya virus isolates
    S R Santhosh
    Division of Virology, Defence R and D Establishment, Gwalior, MP, India
    Virus Res 135:36-41. 2008
    The resurgence of Chikungunya virus (CHIKV) in the form of unprecedented explosive epidemic after a gap of 32 years in India is a point of major public health concern...
  40. ncbi Outbreak of dengue and Chikungunya fevers, Toamasina, Madagascar, 2006
    Mahery Ratsitorahina
    Institut Pasteur de Madagascar, Antananarivo, Madagascar
    Emerg Infect Dis 14:1135-7. 2008
    ..Aedes albopictus was the only potential vector collected. Of 4,242 randomly selected representative residents interviewed retrospectively, 67.5% reported a dengue-like syndrome during this period...
  41. ncbi Atypical Chikungunya virus infections: clinical manifestations, mortality and risk factors for severe disease during the 2005-2006 outbreak on Réunion
    A Economopoulou
    Institute de Veille Sanitaire, France
    Epidemiol Infect 137:534-41. 2009
    ..During winter 2005, six patients developed meningoencephalitis and acute hepatitis due to Chikungunya virus. Our objectives were to determine the incidence and mortality of atypical Chikungunya viral infections and ..
  42. ncbi Type I IFN controls chikungunya virus via its action on nonhematopoietic cells
    Clementine Schilte
    Department of Immunology, Unité Immunobiologie des Cellules Dendritiques, Institut Pasteur, 75724 Paris, Cedex 15, France
    J Exp Med 207:429-42. 2010
    b>Chikungunya virus (CHIKV) is the causative agent of an outbreak that began in La Réunion in 2005 and remains a major public health concern in India, Southeast Asia, and southern Europe...
  43. ncbi A serological study of Chikungunya virus transmission in Yogyakarta, Indonesia: evidence for the first outbreak since 1982
    Kevin R Porter
    Viral Diseases Program, US Naval Medical Research Unit No 2, Jakarta, Indonesia
    Southeast Asian J Trop Med Public Health 35:408-15. 2004
    A study of epidemic transmission of Chikungunya virus (CHIK) was initiated in April 1999 in Yogyakarta, Indonesia. Three hundred seventeen volunteers from three kelurahans (sub-districts) were recruited...
  44. ncbi Chikungunya outbreak, South India, 2006
    Prabhdeep Kaur
    National Institute of Epidemiology, Chennai, India
    Emerg Infect Dis 14:1623-5. 2008
    ..Transmission was facilitated by Aedes aegypti mosquitoes in peridomestic water containers, as indicated by a high Breteau index. We recommended vector control measures and health education to promote safe water storage practices...
  45. ncbi Persistent arthralgia induced by Chikungunya virus infection is associated with interleukin-6 and granulocyte macrophage colony-stimulating factor
    Angela Chow
    Communicable Disease Centre, Singapore
    J Infect Dis 203:149-57. 2011
    b>Chikungunya virus (CHIKV) infection induces arthralgia. The involvement of inflammatory cytokines and chemokines has been suggested, but very little is known about their secretion profile in CHIKV-infected patients.
  46. ncbi Endocytosis of chikungunya virus into mammalian cells: role of clathrin and early endosomal compartments
    Eric Bernard
    Centre d Etudes d Agents Pathogenes et Biotechnologies pour la Sante CPBS, CNRS UMR5236, Universite Montpellier 1, 2, Montpellier, France
    PLoS ONE 5:e11479. 2010
    The replicative cycle of chikungunya virus (CHIKV), an alphavirus that recently re-emerged in India and in Indian Ocean area, remains mostly unknown...
  47. ncbi Chikungunya fever in travelers returning to Europe from the Indian Ocean region, 2006
    Marcus Panning
    Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany
    Emerg Infect Dis 14:416-22. 2008
    ..Soon after onset of symptoms, patients had IgG and IgM and high viral loads (some >10(9) copies/mL plasma). These data will help healthcare providers select diagnostic tests for returning travelers...
  48. ncbi Host immune response to mosquito-transmitted chikungunya virus differs from that elicited by needle inoculated virus
    Saravanan Thangamani
    Department of Pathology, University of Texas Medical Branch, Galveston, Texas, United States of America
    PLoS ONE 5:e12137. 2010
    ..In this report, we compared host immune responses to chikungunya virus (CHIKV) transmission by (1) mosquito bite, or (2) by needle inoculation.
  49. ncbi Presence of the A226V mutation in autochthonous and imported Italian chikungunya virus strains
    Licia Bordi
    Clin Infect Dis 47:428-9. 2008
  50. ncbi Concurrent outbreaks of Chikungunya and Dengue fever in Kandy, Sri Lanka, 2006-07: a comparative analysis of clinical and laboratory features
    S A M Kularatne
    Department of Medicine, Faculty of Medicine, Peradeniya University, Peradeniya, Sri Lanka
    Postgrad Med J 85:342-6. 2009
    ..To compare the clinical and laboratory features of confirmed cases of Chikungunya and Dengue fever; to validate the clinical diagnosis based on serology...
  51. ncbi Chikungunya fever in Singapore: acute clinical and laboratory features, and factors associated with persistent arthralgia
    M K Win
    Department of Clinical Epidemiology, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng 308433, Singapore mar kyaw
    J Clin Virol 49:111-4. 2010
    ..During the initial outbreak period, a strict containment strategy was adopted and all chikungunya PCR-confirmed cases were isolated and hospitalised at the designated national outbreak management centre...
  52. ncbi Wolbachia modulates Chikungunya replication in Aedes albopictus
    L Mousson
    Institut Pasteur, Génétique Moléculaire des Bunyavirus, F 75724 Paris Cedex 15, France
    Mol Ecol 19:1953-64. 2010
    The Aedes albopictus mosquito has been involved as the principal vector of recent major outbreaks due to the chikungunya virus (CHIKV). The species is naturally infected by two strains of Wolbachia (wAlbA and wAlbB)...
  53. ncbi Clinical progression of chikungunya fever during acute and chronic arthritic stages and the changes in joint morphology as revealed by imaging
    Sathya Prakash Manimunda
    Regional Medical Research Centre RMRC ICMR, Post Bag No 13, Dollygunj, Port Blair 744101, Andaman and Nicobar Islands, India
    Trans R Soc Trop Med Hyg 104:392-9. 2010
    ..The study proves with relative certainty that CHIK arthritis is chronic inflammatory erosive arthritis, which has implications for management of the infection...
  54. ncbi Geographic and ecological distribution of the dengue and chikungunya virus vectors Aedes aegypti and Aedes albopictus in three major Cameroonian towns
    B Kamgang
    Unité de Recherche Caractérisation et Contrôle des populations de Vecteurs CCPV, Institut de recherche pour le developpement IRD, Montpellier, France
    Med Vet Entomol 24:132-41. 2010
    ..aegypti tended to breed in containers located in environments with a high density of buildings. These findings may have important implications for vector control strategies...
  55. ncbi Immuno-biology of Chikungunya and implications for disease intervention
    Yiu Wing Kam
    Singapore Immunology Network, Agency for Science, Technology and Research, 8A Biomedical Grove, Biopolis, Singapore
    Microbes Infect 11:1186-96. 2009
    ..This review discusses what is currently known on the immuno-biology of Chikungunya and areas that will be important for the development of immune-based antiviral control strategies...
  56. ncbi Chikungunya: a potentially emerging epidemic?
    Michelle M Thiboutot
    Department of Earth and Environmental Sciences, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
    PLoS Negl Trop Dis 4:e623. 2010
    b>Chikungunya virus is a mosquito-borne emerging pathogen that has a major health impact in humans and causes fever disease, headache, rash, nausea, vomiting, myalgia, and arthralgia...
  57. ncbi Chikungunya virus of Asian and Central/East African genotypes in Malaysia
    I Ching Sam
    Tropical Infectious Diseases Research and Education Centre, Department of Medical Microbiology, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia
    J Clin Virol 46:180-3. 2009
    b>Chikungunya virus (CHIKV) of the Central/East African genotype has caused large outbreaks worldwide in recent years...
  58. ncbi Host alternation of chikungunya virus increases fitness while restricting population diversity and adaptability to novel selective pressures
    Lark L Coffey
    Institut Pasteur, Viral Populations and Pathogenesis, CNRS URA 3015, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
    J Virol 85:1025-35. 2011
    The mechanisms by which RNA arboviruses, including chikungunya virus (CHIKV), evolve and maintain the ability to infect vertebrate and invertebrate hosts are poorly understood...
  59. ncbi Inhibition of Chikungunya virus infection in cultured human muscle cells by furin inhibitors: impairment of the maturation of the E2 surface glycoprotein
    Simona Ozden
    Unité d Epidémiologie et Physiopathologie des Virus Oncogènes, CNRS URA 3015, Institut Pasteur, 75724 Paris, France
    J Biol Chem 283:21899-908. 2008
    b>Chikungunya virus (CHIKV) is a mosquito-transmitted Alphavirus that causes in humans an acute infection characterized by polyarthralgia, fever, myalgia, and headache...
  60. ncbi Chikungunya: an overview
    A B Sudeep
    National Institute of Virology, 20 A, Dr Ambedkar Road, Pune 411 001, India
    J Biosci 33:443-9. 2008
    ..This review describes CHIK in general and highlights the various clinico-pathological aspects observed during the recent outbreak...
  61. ncbi Mucocutaneous features of Chikungunya fever: a study from an outbreak in West Bengal, India
    Debabrata Bandyopadhyay
    Department of Dermatology, Venereology and Leprosy, RG Kar Medical College, Kolkata, India
    Int J Dermatol 47:1148-52. 2008
    ..Chikungunya fever (CF) epidemic has recently re-emerged in India on a large scale affecting many parts of the country. We have reviewed the mucocutaneous manifestations of the disease in a number of cases...
  62. ncbi Imported Chikungunya Infection, Italy
    Anna Beltrame
    Emerg Infect Dis 13:1264-6. 2007
  63. ncbi Blood-feeding behavior of Aedes albopictus, a vector of Chikungunya on La Réunion
    Helene Delatte
    Research Unit 016, Institut de recherche pour le developpement IRD, Saint Pierre, France
    Vector Borne Zoonotic Dis 10:249-58. 2010
    b>Chikungunya virus (CHIKV) has long been considered to be transmitted to humans by the human-biting mosquito Aedes aegypti, especially in Africa...
  64. ncbi Chikungunya virus and Aedes mosquitoes: saliva is infectious as soon as two days after oral infection
    Mathieu Dubrulle
    Institut Pasteur, Génétique Moléculaire des Bunyavirus, Paris, France
    PLoS ONE 4:e5895. 2009
    Aedes aegypti and Aedes albopictus are potential vectors of chikungunya virus (CHIKV)...
  65. ncbi Immunogenicity of novel consensus-based DNA vaccines against Chikungunya virus
    Karuppiah Muthumani
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Vaccine 26:5128-34. 2008
    b>Chikungunya virus (CHIKV) is an emerging arbovirus and is an important human pathogen...
  66. ncbi On chikungunya acute infection and chloroquine treatment
    Xavier de Lamballerie
    Unite des Virus Emergents, Université de la Méditerranée and Institut de Recherche pour le Développement, Marseille, France
    Vector Borne Zoonotic Dis 8:837-9. 2008
    ..01). In conclusion, our results suggest that there is currently no justification for the use of chloroquine to treat acute chikungunya infections...
  67. ncbi Chikungunya in north-eastern Italy: a summing up of the outbreak
    R Angelini
    Dipartimento Sanita Pubblica, Azienda Unita Sanitaria Locale (Department of Public Health, Local Health Unit, Ravenna, Italy
    Euro Surveill 12:E071122.2. 2007
  68. ncbi First report of chikungunya from the Maldives
    Abdul Azeez Yoosuf
    Ministry of Health, Malé 20379, Republic of Maldives
    Trans R Soc Trop Med Hyg 103:192-6. 2009
    ..The illness was suspected as being due to chikungunya virus based on clinical symptoms and the prevailing chikungunya epidemic in the Indian Ocean region...
  69. ncbi An outbreak of yellow fever with concurrent chikungunya virus transmission in South Kordofan, Sudan, 2005
    L Hannah Gould
    Division of Vector Borne Infectious Diseases, National Center for Zoonotic, Vector Borne and Enteric Diseases, Centers for Disease Control and Prevention, Fort Collins, CO, USA
    Trans R Soc Trop Med Hyg 102:1247-54. 2008
    ..IgM antibodies to chikungunya virus were detected in five (27%) ill persons and three (19%) asymptomatic persons...
  70. ncbi Neurologic manifestations of pediatric chikungunya infection
    Stephanie Robin
    Service de Pediatrie, centre hospitalier départemental Félix Guyon, La Reunion, France
    J Child Neurol 23:1028-35. 2008
    b>Chikungunya virus, a mosquito-borne arbovirus, was responsible for a massive epidemic in La Réunion Island during 2005 to 2006. The disease is usually benign, but neurologic involvement, with sometimes fatal outcome, has been described...
  71. ncbi Destructive arthritis in a patient with chikungunya virus infection with persistent specific IgM antibodies
    Denis Malvy
    Travel Clinics and Tropical Disease Unit, Department of Internal Medicine, Infectious Diseases and Tropical Medicine, University Hospital Center, Bordeaux, F 33075 France
    BMC Infect Dis 9:200. 2009
    ..Up to now, the pathophysiology of the chronic stage is poorly understood...
  72. ncbi Prophylaxis and therapy for Chikungunya virus infection
    Thérèse Couderc
    Groupe Microorganismes et Barrières de l Hôte and Unité Interactions Moléculaires Flavivirus Hôtes, Centre National de Référence des Arbovirus, Institut Pasteur, INSERM, Avenir U604, and Universite Paris Descartes, Hopital Necker Enfants Malades, Paris, France
    J Infect Dis 200:516-23. 2009
    b>Chikungunya virus (CHIKV) is a recently reemerged arbovirus responsible for a massive outbreak of infection in the Indian Ocean region and India that has a very significant potential to spread globally because of the worldwide ..
  73. ncbi The Chikungunya epidemic in Italy and its repercussion on the blood system
    Giancarlo Maria Liumbruno
    Centro Nazionale Sangue, Istituto Superiore di Sanita, Roma, Italy
    Blood Transfus 6:199-210. 2008
    The Chikungunya virus (CHIKV) is transmitted by Aedes mosquitoes and recently caused a massive epidemic on La Réunion Island, in the Indian Ocean...
  74. ncbi Assessment of immunogenic potential of Vero adapted formalin inactivated vaccine derived from novel ECSA genotype of Chikungunya virus
    Mugdha Tiwari
    Defence Research and Development Establishment, Gwalior, M P, India
    Vaccine 27:2513-22. 2009
    The recent resurgence of Chikungunya virus (CHIKV) in India and Indian Ocean Islands with unusual clinical severity is a matter of great public health concern...
  75. ncbi Chikungunya: a risk for Mediterranean countries?
    Marie Vazeille
    Institut Pasteur, Génétique Moléculaire des Bunyavirus, 25 28 Rue du Dr Roux, F 75724 Paris Cedex 15, France
    Acta Trop 105:200-2. 2008
    ....
  76. ncbi Chikungunya virus in Aedes albopictus, Italy
    Paolo Bonilauri
    Emerg Infect Dis 14:852-4. 2008
  77. ncbi Chikungunya virus takes centre stage in virally induced arthritis: possible cellular and molecular mechanisms to pathogenesis
    Marie Christine Jaffar-Bandjee
    Infection Research Grouping, University of La Réunion, St Denis, Ile de La Réunion
    Microbes Infect 11:1206-18. 2009
    b>Chikungunya virus (CHIKV) causes an acute symptomatic illness with fever, skin rash (hypersensitivity vasculitis), incapacitating arthralgia which can evolve to chronic arthritis in elderly patients...
  78. ncbi Pan-European Chikungunya surveillance: designing risk stratified surveillance zones
    Natasha Tilston
    ieSim, London, United Kingdom, formerly at the Institute for the Environment, Brunel University West London, Uxbridge, UK
    Int J Health Geogr 8:61. 2009
    ..Therefore this study represents a first attempt at creating risk stratified surveillance zones, which we believe could be usefully refined with the use of higher resolution climate data and more complete air travel data...
  79. ncbi Chimeric alphavirus vaccine candidates for chikungunya
    Eryu Wang
    Center for Biodefense and Emerging Infectious Diseases, and Sealy Center for Vaccine Development, University of Texas Medical Branch, Galveston, TX 77555, United States
    Vaccine 26:5030-9. 2008
    b>Chikungunya virus (CHIKV) is an emerging alphavirus that has caused major epidemics in India and islands off the east coast of Africa since 2005...
  80. ncbi Chikungunya: a review
    Manisha Jain
    Department of Microbiology, Maulana Azad Medical College, New Delhi 110 002, India
    Trop Doct 38:70-2. 2008
    The Chikungunya virus (CHIKV) is a mosquito-borne Alphavirus, which causes epidemics of fever, rash and polyarthralgia in Africa and Asia...
  81. ncbi A report of 21 cases of rheumatoid arthritis following Chikungunya fever. A mean follow-up of two years
    Eric Bouquillard
    Service de Rhumatologie, 39, rue du Four à Chaux, 97410 Saint Pierre, France
    Joint Bone Spine 76:654-7. 2009
    ..We report 21 cases of rheumatoid arthritis (RA) after Chikungunya infection that were diagnosed at a rheumatological centre in Reunion Island...
  82. ncbi Expression and evaluation of Chikungunya virus E1 and E2 envelope proteins for serodiagnosis of Chikungunya virus infection
    ByungKi Cho
    Standard Diagnostics Inc, Yongin, Korea
    Yonsei Med J 49:828-35. 2008
    b>Chikungunya virus (CHIKV) causes endemic or epidemic outbreaks of CHIKV fever, which is a mosquitoe- transmitted viral disease in Africa, India, South-East Asia, and recently Southern Europe...
  83. ncbi Factors associated with persistence of arthralgia among Chikungunya virus-infected travellers: report of 42 French cases
    Sophie Larrieu
    Cellule Interrégionale d Epidémiologie d Aquitaine, Bordeaux, France
    J Clin Virol 47:85-8. 2010
    ..In 2005-2006, a major epidemic of CHIKV infection occurred in the Islands of the south-western Indian Ocean, and longstanding manifestations seemed to be more frequent than described before...
  84. ncbi Infectious clones of Chikungunya virus (La Réunion isolate) for vector competence studies
    Konstantin Tsetsarkin
    Department of Pathology, University of Texas Medical Branch, Galveston, Texas 77539-0609, USA
    Vector Borne Zoonotic Dis 6:325-37. 2006
    The recent outbreak of Chikungunya virus (CHIKV) on several islands in the Indian Ocean and in India has focused attention on this reemerging virus and highlighted the need for development of new tools to study vector-virus-host ..
  85. ncbi Design of chimeric alphaviruses with a programmed, attenuated, cell type-restricted phenotype
    Dal Young Kim
    Department of Microbiology, BBRB 373 Box 3, University of Alabama, 1530 Third Avenue South, Birmingham, AL 35294 2170, USA
    J Virol 85:4363-76. 2011
    ..The importance of alphaviruses has been strongly underappreciated; however, epidemics of chikungunya virus (CHIKV), causing millions of cases of severe and often persistent arthritis in the Indian subcontinent, have ..
  86. ncbi Limited potential for mosquito transmission of a live, attenuated chikungunya virus vaccine
    M J Turell
    Department of Arboviral Entomology, U S Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland
    Am J Trop Med Hyg 47:98-103. 1992
    ..Although the vaccine was transmitted by mosquitoes after intrathoracic inoculation, there was no evidence of reversion to a virulent phenotype...
  87. ncbi [The Chikungunya virus]
    E Nakoune
    Laboratoire de Virologie, CHU de Nancy
    Ann Biol Clin (Paris) 65:349-56. 2007
    b>Chikungunya virus (CHIKV), a member of the Alphavirus genus, represents a real public health problem in tropical regions of the Southeast Asia and Africa...
  88. ncbi Recently introduced Aedes albopictus in Corsica is competent to Chikungunya virus and in a lesser extent to dengue virus
    Sara Moutailler
    Institut Pasteur, Génétique Moléculaire des Bunyavirus, Paris, France
    Trop Med Int Health 14:1105-9. 2009
    ..The risk for a local transmission of CHIK is thus likely in Corsica, if other parameters determining the vector capacity of A. albopictus are suitable...
  89. ncbi The 2007 epidemic outbreak of Chikungunya virus infection in the Romagna region of Italy: a new perspective for the possible diffusion of tropical diseases in temperate areas?
    Vittorio Sambri
    New Microbiol 31:303-4. 2008
  90. ncbi Chikungunya fever in the United States: a fifteen year review of cases
    Katherine B Gibney
    Arboviral Diseases Branch, Division of Vector Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado, USA
    Clin Infect Dis 52:e121-6. 2011
    b>Chikungunya virus (CHIKV) represents a threat to the United States, because humans amplify CHIKV and vectors that transmit CHIKV are present.
  91. ncbi A mouse model of chikungunya virus-induced musculoskeletal inflammatory disease: evidence of arthritis, tenosynovitis, myositis, and persistence
    Thomas E Morrison
    Department of Microbiology, University of Colorado School of Medicine, Aurora, Colorado 80045, USA
    Am J Pathol 178:32-40. 2011
    b>Chikungunya virus (CHIKV), an emerging mosquito-borne Alphavirus, causes debilitating rheumatic disease in humans that can last for weeks to months...
  92. ncbi Entomology. A mosquito goes global
    Martin Enserink
    Science 320:864-6. 2008
  93. ncbi Chikungunya epidemic outbreak in Emilia-Romagna (Italy) during summer 2007
    P Angelini
    Public Health Service of Emilia Romagna Region, Bologna
    Parassitologia 50:97-8. 2008
    ..CHIKV has been isolated and characterized on both blood and mosquito samples...
  94. ncbi Emergence of chikungunya virus in Indian subcontinent after 32 years: A review
    Chandrakant Lahariya
    Department of Community Medicine, Lady Hardinge Medical College, New Delhi, India
    J Vector Borne Dis 43:151-60. 2006
    An outbreak of chikungunya virus is currently ongoing in many countries in Indian Ocean since January 2005. The current outbreak appears to be the most severe and one of the biggest outbreaks caused by this virus...
  95. ncbi A226V mutation in virus during the 2007 chikungunya outbreak in Kerala, India
    N Pradeep Kumar
    Vector Control Research Centre ICMR, Indira Nagar, Pondicherry, India
    J Gen Virol 89:1945-8. 2008
    Kerala State in India was gripped by a renewed and widespread outbreak of Chikungunya virus (CHIKV) infection during 2007...
  96. ncbi Combined detection and genotyping of Chikungunya virus by a specific reverse transcription-polymerase chain reaction
    F Hasebe
    Department of Virology, Institute of Tropical Medicine, Nagasaki University, Sakamoto, Nagasaki, Japan
    J Med Virol 67:370-4. 2002
    A reverse transcription-polymerase chain reaction (RT-PCR) was developed for the detection of Chikungunya virus infection...
  97. ncbi Failure to control mosquitoes has led to two fever epidemics in India
    Ganapati Mudur
    BMJ 333:773. 2006
  98. ncbi Novel chikungunya virus variant in travelers returning from Indian Ocean islands
    Philippe Parola
    , Marseilles, France
    Emerg Infect Dis 12:1493-9. 2006
    b>Chikungunya virus (CHIKV) emerged in Indian Ocean islands in 2005 and is causing an ongoing outbreak that involves >260,000 patients, including travelers returning home from these islands...
  99. ncbi Chikungunya infection in travelers
    Patrick Hochedez
    , Paris, France
    Emerg Infect Dis 12:1565-7. 2006
    The largest described outbreak of chikungunya virus has been occurring on the islands of the southwest Indian Ocean since March 2005...
  100. ncbi Chikungunya outbreaks caused by African genotype, India
    Prasanna N Yergolkar
    National Institute of Virology, Pune, India
    Emerg Infect Dis 12:1580-3. 2006
    ..Phylogenic analysis based on partial sequences of NS4 and E1 genes showed that all earlier isolates (1963-1973) were Asian genotype, whereas the current and Yawat (2000) isolates were African genotype...
  101. ncbi Chikungunya
    Sandhya Kamath
    Department of Medicine, TN Medical College, BYL Nair Ch Hospital, Mumbai
    J Assoc Physicians India 54:725-6. 2006
    ..Chikungunya is a self-limiting illness with no specific treatment. Travellers visiting endemic areas should be careful and take precautions to see that they are not bitten by mosquitoes...

Research Grants95

  1. Mechanisms of sylvatic dengue emergence
    Scott Weaver; Fiscal Year: 2009
    ....
  2. Mechanisms of sylvatic dengue emergence
    Scott C Weaver; Fiscal Year: 2010
    ....
  3. Antibody Based Therapeuticcs for Chikungunya Virus
    Michael S Diamond; Fiscal Year: 2010
    b>Chikungunya virus (CHIKV) is a mosquito-transmitted, single-stranded RNA alphavirus of the Togaviridae family that causes explosive epidemics of a severe febrile illness characterized by debilitating polyarthalgias in humans...
  4. Arbovirus Evasion of Type I Interferon Induction
    Mark Heise; Fiscal Year: 2007
    ....
  5. Immune Evasion Mechanisms of Neurovirulent Alphaviruses
    Mark Heise; Fiscal Year: 2009
    ....
  6. Immune Evasion Mechanisms of Neurovirulent Alphaviruses
    Mark T Heise; Fiscal Year: 2011
    ....
  7. TOGAVIRUS TROPISM FOR BONES, JOINTS, AND CNS
    Mark Heise; Fiscal Year: 2004
    ..abstract_text> ..
  8. TOGAVIRUS TROPISM FOR BONES, JOINTS, AND CNS
    Mark T Heise; Fiscal Year: 2010
    ....
  9. TOGAVIRUS TROPISM FOR BONES, JOINTS, AND CNS
    Mark Heise; Fiscal Year: 2009
    ....
  10. TOGAVIRUS TROPISM FOR BONES, JOINTS, AND CNS
    Mark Heise; Fiscal Year: 2007
    ....
  11. Immune Evasion Mechanisms of Neurovirulent Alphaviruses
    Mark T Heise; Fiscal Year: 2010
    ....
  12. Improved Vaccines for Rift Valley Fever Virus
    Mark T Heise; Fiscal Year: 2010
    ....
  13. TRAINING:MOLECULAR & CELLULAR BASES OF INFECTIOUS DISEAS
    Diane Griffin; Fiscal Year: 2007
    ..Participation in seminars, journal clubs, the Departmental retreat, and Research Forum will also be required. ..
  14. IMMUNE RESPONSE DURING MEASLES VIRUS INFECTION
    Diane Griffin; Fiscal Year: 2001
    ....
  15. EPIDEMIC CHIKUNGUNYA VIRUS: MOSQUITO INFECTION DETERMINANTS
    Stephen Higgs; Fiscal Year: 2007
    ..It builds upon our groups unusual expertise on chikungunya virus (CHIKV), a virus that has recently caused over 255,000 human cases in La Reunion, over 100,000 cases in ..
  16. Salivary Potentiation of Arboviral Infections
    Stephen Higgs; Fiscal Year: 2004
    ..This knowledge may contribute towards the development of a mouse model for human dengue infections. ..
  17. ACUTE ALPHAVIRAL ENCEPHALITIS
    Diane Griffin; Fiscal Year: 1993
    ..5) To determine the relative contributions of structural and nonstructural protein coding regions of Sindbis and Ross River viruses to the development of encephalitis versus myositis in mice...
  18. VEE Virus Infection on the Mosquito Vector
    Scott C Weaver; Fiscal Year: 2010
    ..The results will add to our understanding of the mechanisms of epidemic VEEV emergence and provide new viral and host targets for the development of safer vaccines and novel strategies to interrupt transmission. ..
  19. ECOLOGY AND GENETICS OF VENEZUELAN EQUINE ENCEPHALITIS
    Scott Weaver; Fiscal Year: 2005
    ..This information will be invaluable in targeting prevention and control resources, especially for obtaining maximum benefit in developing countries with limited resources. ..
  20. A Drosophila model of Batten Disease
    Robert Glaser; Fiscal Year: 2004
    ..The specific aims of the proposal are: 1. Determine the phenotypic consequences of removing DmPPT1 function by gene mutation. 2. Determine the phenotypic consequences of disrupting DmPPT1 function by RNA interference. ..
  21. GENETIC DETERMINANTS OF EPIDEMIC ALPHAVIRUS TRANSMISSION
    Stephen Higgs; Fiscal Year: 2002
    ..abstract_text> ..
  22. Biodefense Training Program
    Scott Weaver; Fiscal Year: 2007
    ..An external advisory committee composed of outstanding, internationally recognized biodefense scientists and experienced research mentors will periodically review and guide the program through site visits. ..