chikungunya virus

Summary

Summary: A species of ALPHAVIRUS causing an acute dengue-like fever.

Top Publications

  1. pmc A single mutation in chikungunya virus affects vector specificity and epidemic potential
    Konstantin A Tsetsarkin
    Department of Pathology, University of Texas Medical Branch, Galveston, Texas, United States of America
    PLoS Pathog 3:e201. 2007
  2. ncbi Infection with chikungunya virus in Italy: an outbreak in a temperate region
    G Rezza
    Department of Infectious, Parasitic, and Immunomediated Diseases, Istituto Superiore di Sanita, Rome, Italy
    Lancet 370:1840-6. 2007
  3. pmc Chikungunya virus, southeastern France
    Marc Grandadam
    Institut Pasteur, Paris, France
    Emerg Infect Dis 17:910-3. 2011
  4. doi Chikungunya fever: an epidemiological review of a re-emerging infectious disease
    J Erin Staples
    Arboviral Diseases Branch, Division of Vector Borne Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado 80521, USA
    Clin Infect Dis 49:942-8. 2009
  5. pmc Larval environmental temperature and the susceptibility of Aedes albopictus Skuse (Diptera: Culicidae) to Chikungunya virus
    Catherine J Westbrook
    Florida Medical Entomology Laboratory, Department of Entomology and Nematology, Institute of Food and Agricultural Sciences, University of Florida, Vero Beach, Florida 32962, USA
    Vector Borne Zoonotic Dis 10:241-7. 2010
  6. pmc Chikungunya: a potentially emerging epidemic?
    Michelle M Thiboutot
    Department of Earth and Environmental Sciences, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
    PLoS Negl Trop Dis 4:e623. 2010
  7. ncbi Biology and pathogenesis of chikungunya virus
    Olivier Schwartz
    Institut Pasteur, 28 rue du Dr Roux, Paris 75724 Cedex 15, France
    Nat Rev Microbiol 8:491-500. 2010
  8. pmc Chikungunya disease in nonhuman primates involves long-term viral persistence in macrophages
    Karine Labadie
    CEA, Division of Immuno Virology Institute of Emerging Diseases and Innovative Therapies, Fontenay aux Roses, France
    J Clin Invest 120:894-906. 2010
  9. pmc Persistent arthralgia induced by Chikungunya virus infection is associated with interleukin-6 and granulocyte macrophage colony-stimulating factor
    Angela Chow
    Communicable Disease Centre, Singapore
    J Infect Dis 203:149-57. 2011
  10. pmc Sequential adaptive mutations enhance efficient vector switching by Chikungunya virus and its epidemic emergence
    Konstantin A Tsetsarkin
    Institute for Human Infections and Immunity, Center for Tropical Diseases, and Department of Pathology, University of Texas Medical Branch, Galveston, Texas, United States of America
    PLoS Pathog 7:e1002412. 2011

Detail Information

Publications244 found, 100 shown here

  1. pmc A single mutation in chikungunya virus affects vector specificity and epidemic potential
    Konstantin A Tsetsarkin
    Department of Pathology, University of Texas Medical Branch, Galveston, Texas, United States of America
    PLoS Pathog 3:e201. 2007
    b>Chikungunya virus (CHIKV) is an emerging arbovirus associated with several recent large-scale epidemics...
  2. ncbi Infection with chikungunya virus in Italy: an outbreak in a temperate region
    G Rezza
    Department of Infectious, Parasitic, and Immunomediated Diseases, Istituto Superiore di Sanita, Rome, Italy
    Lancet 370:1840-6. 2007
    b>Chikungunya virus (CHIKV), which is transmitted by Aedes spp mosquitoes, has recently caused several outbreaks on islands in the Indian Ocean and on the Indian subcontinent. We report on an outbreak in Italy.
  3. pmc Chikungunya virus, southeastern France
    Marc Grandadam
    Institut Pasteur, Paris, France
    Emerg Infect Dis 17:910-3. 2011
    In September 2010, autochthonous transmission of chikungunya virus was recorded in southeastern France, where the Aedes albopictus mosquito vector is present...
  4. doi Chikungunya fever: an epidemiological review of a re-emerging infectious disease
    J Erin Staples
    Arboviral Diseases Branch, Division of Vector Borne Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado 80521, USA
    Clin Infect Dis 49:942-8. 2009
    ..The disease is caused by Chikungunya virus (CHIKV), an arthropod-borne virus that is transmitted to humans primarily via the bite of an infected ..
  5. pmc Larval environmental temperature and the susceptibility of Aedes albopictus Skuse (Diptera: Culicidae) to Chikungunya virus
    Catherine J Westbrook
    Florida Medical Entomology Laboratory, Department of Entomology and Nematology, Institute of Food and Agricultural Sciences, University of Florida, Vero Beach, Florida 32962, USA
    Vector Borne Zoonotic Dis 10:241-7. 2010
    A key feature in the recent widespread epidemic of the mosquito-borne alphavirus chikungunya virus (CHIKV) was the important role of Aedes albopictus, formerly regarded as a secondary vector, compared to the presumed primary vector Aedes ..
  6. pmc Chikungunya: a potentially emerging epidemic?
    Michelle M Thiboutot
    Department of Earth and Environmental Sciences, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
    PLoS Negl Trop Dis 4:e623. 2010
    b>Chikungunya virus is a mosquito-borne emerging pathogen that has a major health impact in humans and causes fever disease, headache, rash, nausea, vomiting, myalgia, and arthralgia...
  7. ncbi Biology and pathogenesis of chikungunya virus
    Olivier Schwartz
    Institut Pasteur, 28 rue du Dr Roux, Paris 75724 Cedex 15, France
    Nat Rev Microbiol 8:491-500. 2010
    b>Chikungunya virus (CHIKV) is a re-emerging mosquito-borne alphavirus responsible for a recent, unexpectedly severe epidemic in countries of the Indian Ocean region...
  8. pmc Chikungunya disease in nonhuman primates involves long-term viral persistence in macrophages
    Karine Labadie
    CEA, Division of Immuno Virology Institute of Emerging Diseases and Innovative Therapies, Fontenay aux Roses, France
    J Clin Invest 120:894-906. 2010
    b>Chikungunya virus (CHIKV) is a mosquito-borne alphavirus that induces in humans a disease characterized by fever, rash, and pain in muscles and joints...
  9. pmc Persistent arthralgia induced by Chikungunya virus infection is associated with interleukin-6 and granulocyte macrophage colony-stimulating factor
    Angela Chow
    Communicable Disease Centre, Singapore
    J Infect Dis 203:149-57. 2011
    b>Chikungunya virus (CHIKV) infection induces arthralgia. The involvement of inflammatory cytokines and chemokines has been suggested, but very little is known about their secretion profile in CHIKV-infected patients.
  10. pmc Sequential adaptive mutations enhance efficient vector switching by Chikungunya virus and its epidemic emergence
    Konstantin A Tsetsarkin
    Institute for Human Infections and Immunity, Center for Tropical Diseases, and Department of Pathology, University of Texas Medical Branch, Galveston, Texas, United States of America
    PLoS Pathog 7:e1002412. 2011
    The adaptation of Chikungunya virus (CHIKV) to a new vector, the Aedes albopictus mosquito, is a major factor contributing to its ongoing re-emergence in a series of large-scale epidemics of arthritic disease in many parts of the world ..
  11. pmc Characterization of reemerging chikungunya virus
    Marion Sourisseau
    Department of Virology, Unité Virus et Immunite, Institut Pasteur, Paris, France
    PLoS Pathog 3:e89. 2007
    An unprecedented epidemic of chikungunya virus (CHIKV) infection recently started in countries of the Indian Ocean area, causing an acute and painful syndrome with strong fever, asthenia, skin rash, polyarthritis, and lethal cases of ..
  12. ncbi Influence of temperature on immature development, survival, longevity, fecundity, and gonotrophic cycles of Aedes albopictus, vector of chikungunya and dengue in the Indian Ocean
    H Delatte
    Research Unit 016, Institut de recherche pour le developpement IRD, 7 chemin de l IRAT, 97410 Saint Pierre, La Reunion, France
    J Med Entomol 46:33-41. 2009
    ..5 d). Those results are according to the field repartition of this species in La Réunion, allowing Ae. albopictus survival at a large range of temperatures...
  13. ncbi Outbreak of chikungunya on Reunion Island: early clinical and laboratory features in 157 adult patients
    Gianandrea Borgherini
    Service de Pneumologie et Maladies Infectieuses, Groupe Hospitalier Sud Reunion, Saint Pierre, La Reunion, France
    Clin Infect Dis 44:1401-7. 2007
    ..Chikungunya is a reemerging disease. In 2005-2006, a severe outbreak occurred on Reunion Island in the southwestern part of the Indian Ocean. Other islands in this area were affected during the same period...
  14. pmc Chikungunya virus emergence is constrained in Asia by lineage-specific adaptive landscapes
    Konstantin A Tsetsarkin
    Institute for Human Infections and Immunity, Center for Tropical Diseases and Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA
    Proc Natl Acad Sci U S A 108:7872-7. 2011
    ..However, lineage-specific restrictions on the adaptive processes remain largely unexplored. Recently, a Chikungunya virus (CHIKV) lineage of African origin emerged to cause major epidemics of severe, persistent, debilitating ..
  15. pmc Chikungunya triggers an autophagic process which promotes viral replication
    Pascale Krejbich-Trotot
    IRG, EA 4517, Immunopathology and Infection Research Grouping, CHR North Felix Guyon and University of La Reunion, St Denis, Ile de La Réunion, France
    Virol J 8:432. 2011
    b>Chikungunya Virus (ChikV) surprised by a massive re-emerging outbreak in Indian Ocean in 2006, reaching Europe in 2007 and exhibited exceptional severe physiopathology in infants and elderly patients...
  16. ncbi Persistent chronic inflammation and infection by Chikungunya arthritogenic alphavirus in spite of a robust host immune response
    Jean Jacques Hoarau
    Biology Unit, Centre Hospitalier Régional Nord Félix Guyon and Cyclotron Réunion Océan Indien, Universite de la Reunion, St Denis, France
    J Immunol 184:5914-27. 2010
    Alphaviruses, including Chikungunya virus (CHIKV), produce a transient illness in humans, but severe forms leading to chronic incapacitating arthralgia/arthritis have been reported by mechanisms largely ill-characterized...
  17. pmc Genome microevolution of chikungunya viruses causing the Indian Ocean outbreak
    Isabelle Schuffenecker
    Centre National de Référence des Arbovirus, Institut Pasteur, Lyon, France
    PLoS Med 3:e263. 2006
    A chikungunya virus outbreak of unprecedented magnitude is currently ongoing in Indian Ocean territories. In Réunion Island, this alphavirus has already infected about one-third of the human population...
  18. pmc Genome-scale phylogenetic analyses of chikungunya virus reveal independent emergences of recent epidemics and various evolutionary rates
    Sara M Volk
    University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555 0609
    J Virol 84:6497-504. 2010
    b>Chikungunya virus (CHIKV), a mosquito-borne alphavirus, has traditionally circulated in Africa and Asia, causing human febrile illness accompanied by severe, chronic joint pain...
  19. doi Chikungunya virus mobilizes the apoptotic machinery to invade host cell defenses
    Pascale Krejbich-Trotot
    GRI IRG Immunopathology and Infection Research Grouping, University of La Réunion, CYROI, 2 rue Maxime Rivière, 97491, Ste Clotilde, Reunion
    FASEB J 25:314-25. 2011
    b>Chikungunya virus (CHIKV) surprised medical workers by a massive outbreak in the Indian Ocean region, reaching Europe in 2007, with exceptional pathologies in infants and elderly patients...
  20. pmc Chikungunya virus arthritis in adult wild-type mice
    Joy Gardner
    Queensland Institute of Medical Research, Australian Centre for International and Tropical Health, Brisbane, Australia
    J Virol 84:8021-32. 2010
    b>Chikungunya virus is a mosquito-borne arthrogenic alphavirus that has recently reemerged to produce the largest epidemic ever documented for this virus...
  21. doi Glycoprotein organization of Chikungunya virus particles revealed by X-ray crystallography
    James E Voss
    Institut Pasteur, Departement de Virologie, Unité de Virologie Structurale, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    Nature 468:709-12. 2010
    b>Chikungunya virus (CHIKV) is an emerging mosquito-borne alphavirus that has caused widespread outbreaks of debilitating human disease in the past five years...
  22. pmc Chikungunya virus and Aedes mosquitoes: saliva is infectious as soon as two days after oral infection
    Mathieu Dubrulle
    Institut Pasteur, Génétique Moléculaire des Bunyavirus, Paris, France
    PLoS ONE 4:e5895. 2009
    Aedes aegypti and Aedes albopictus are potential vectors of chikungunya virus (CHIKV)...
  23. pmc Entomologic and virologic investigation of Chikungunya, Singapore
    Lee Ching Ng
    National Environment Agency, Singapore
    Emerg Infect Dis 15:1243-9. 2009
    ..These findings led to a revision of the current vector control strategy in Singapore. This report highlights the use of entomologic and virologic data to assist in the control of chikungunya in disease-endemic areas...
  24. pmc Sentinel surveillance system for early outbreak detection in Madagascar
    Laurence Randrianasolo
    Unite d Epidemiologie, Institut Pasteur de Madagascar, Antananarivo, République de Madagascar
    BMC Public Health 10:31. 2010
    ..We describe the challenges and steps involved in developing a sentinel surveillance system and the well-timed information it provides for improving public health decision-making...
  25. pmc A virus-like particle vaccine for epidemic Chikungunya virus protects nonhuman primates against infection
    Wataru Akahata
    Vaccine Research Center, National Institute of Allergy and Infectious Diseases, US National Institutes of Health, Bethesda, Maryland, USA
    Nat Med 16:334-8. 2010
    b>Chikungunya virus (CHIKV) has infected millions of people in Africa, Europe and Asia since this alphavirus reemerged from Kenya in 2004...
  26. ncbi Active infection of human blood monocytes by Chikungunya virus triggers an innate immune response
    Zhisheng Her
    Singapore Immunology Network, Agency for Science, Technology and Research, Biopolis, Singapore
    J Immunol 184:5903-13. 2010
    b>Chikungunya virus (CHIKV) is an alphavirus that causes chronic and incapacitating arthralgia in humans. To date, interactions between the immune system and the different stages of the virus life cycle remain poorly defined...
  27. doi Entomology. A mosquito goes global
    Martin Enserink
    Science 320:864-6. 2008
  28. pmc Two Chikungunya isolates from the outbreak of La Reunion (Indian Ocean) exhibit different patterns of infection in the mosquito, Aedes albopictus
    Marie Vazeille
    Département de Virologie Chikungunya program, Institut Pasteur, Paris, France
    PLoS ONE 2:e1168. 2007
    ..The implicated vector was Aedes albopictus. Here, we present the first study on the susceptibility of Ae. albopictus populations to sympatric CHIKV isolates from La Réunion Island and compare it to other virus/vector combinations...
  29. pmc Impact of Chikungunya virus infection on health status and quality of life: a retrospective cohort study
    Man Koumba Soumahoro
    Universite Pierre et Marie Curie, Unité Mixte de Recherche en Santé 707, Paris, France
    PLoS ONE 4:e7800. 2009
    Persistent symptoms, mainly joint and muscular pain and depression, have been reported several months after Chikungunya virus (CHIKV) infection...
  30. ncbi Chikungunya, an epidemic arbovirosis
    Gilles Pialoux
    Hopital Tenon, Service des Maladies Infectieuses et Tropicales, Paris, France
    Lancet Infect Dis 7:319-27. 2007
    ..The virus was first isolated in 1953 in Tanzania. Chikungunya virus is a member of the genus Alphavirus and the family Togaviridae...
  31. ncbi Wolbachia modulates Chikungunya replication in Aedes albopictus
    L Mousson
    Institut Pasteur, Génétique Moléculaire des Bunyavirus, F 75724 Paris Cedex 15, France
    Mol Ecol 19:1953-64. 2010
    The Aedes albopictus mosquito has been involved as the principal vector of recent major outbreaks due to the chikungunya virus (CHIKV). The species is naturally infected by two strains of Wolbachia (wAlbA and wAlbB)...
  32. doi Re-emergence of Chikungunya virus in South-east Asia: virological evidence from Sri Lanka and Singapore
    H C Hapuarachchi
    National Environment Agency, Environmental Health Institute, Singapore
    J Gen Virol 91:1067-76. 2010
    ..However, molecular epidemiological data to explain the recent spread and evolution of Chikungunya virus (CHIKV) in the Asian region are still limited...
  33. pmc IL-1beta, IL-6, and RANTES as biomarkers of Chikungunya severity
    Lisa F P Ng
    Singapore Immunology Network, Agency for Science, Technology and Research, Singapore
    PLoS ONE 4:e4261. 2009
    Little is known about the immunopathogenesis of Chikungunya virus. Circulating levels of immune mediators and growth factors were analyzed from patients infected during the first Singaporean Chikungunya fever outbreak in early 2008 to ..
  34. pmc Replication cycle of chikungunya: a re-emerging arbovirus
    Maxime Solignat
    Universite Montpellier 1, Centre d Etudes d Agents Pathogenes et Biotechnologies pour la Sante CPBS, Montpellier, France
    Virology 393:183-97. 2009
    ..The 2005-2006 year unprecedented epidemics of chikungunya virus (CHIKV) in the French Reunion Island in the Indian Ocean, followed by several outbreaks in other parts of ..
  35. pmc Type I IFN controls chikungunya virus via its action on nonhematopoietic cells
    Clementine Schilte
    Department of Immunology, Unité Immunobiologie des Cellules Dendritiques, Institut Pasteur, 75724 Paris, Cedex 15, France
    J Exp Med 207:429-42. 2010
    b>Chikungunya virus (CHIKV) is the causative agent of an outbreak that began in La Réunion in 2005 and remains a major public health concern in India, Southeast Asia, and southern Europe...
  36. ncbi Changing patterns of chikungunya virus: re-emergence of a zoonotic arbovirus
    Ann M Powers
    Division of Vector Borne Infectious Diseases, Centers for Disease Control and Prevention, 3150 Rampart Road, Fort Collins, CO 80521, USA
    J Gen Virol 88:2363-77. 2007
  37. ncbi [Aedes albopictus, vector of chikungunya and dengue viruses in Reunion Island: biology and control]
    H Delatte
    UR 016, IRD, BP 64501, 34394 Montpellier 5, France
    Parasite 15:3-13. 2008
    b>Chikungunya virus (CHIKV) and dengue virus (DENV) are mosquito-borne viruses transmitted by the Aedes genus. Dengue is considered as the most important arbovirus disease throughout the World...
  38. pmc Estimating Chikungunya prevalence in La Réunion Island outbreak by serosurveys: two methods for two critical times of the epidemic
    Patrick Gerardin
    Centre d Investigation Clinique Epidémiologie Clinique de La Réunion, Institut National de la Sante et de la Recherche Medicale, Groupe Hospitalier Sud Reunion, Saint Pierre
    BMC Infect Dis 8:99. 2008
    b>Chikungunya virus (CHIKV) caused a major two-wave seventeen-month-long outbreak in La Réunion Island in 2005-2006...
  39. ncbi Antiviral treatment of chikungunya virus infection
    Xavier de Lamballerie
    Unite des Virus Emergents, UMR190 IRD Université de la Méditerranée Assistance Publique Hôpitaux de Marseille, Faculte de Medecine, Marseille, France
    Infect Disord Drug Targets 9:101-4. 2009
    b>Chikungunya virus is a typical emerging virus which has been responsible for several million cases of human infections since 2004. No antiviral treatment is currently available...
  40. pmc Novel chikungunya vaccine candidate with an IRES-based attenuation and host range alteration mechanism
    Kenneth Plante
    Institute for Human Infections and Immunity, Sealy Center for Vaccine Development, and Department of Pathology, University of Texas Medical Branch, Galveston, Texas, United States of America
    PLoS Pathog 7:e1002142. 2011
    b>Chikungunya virus (CHIKV) is a reemerging mosquito-borne pathogen that has recently caused devastating urban epidemics of severe and sometimes chronic arthralgia...
  41. ncbi Chikungunya virus impacts the diversity of symbiotic bacteria in mosquito vector
    Karima Zouache
    Universite de Lyon, F 69622 Lyon, France
    Mol Ecol 21:2297-309. 2012
    Mosquitoes transmit numerous arboviruses including dengue and chikungunya virus (CHIKV)...
  42. pmc Chikungunya virus induces IPS-1-dependent innate immune activation and protein kinase R-independent translational shutoff
    Laura K White
    Oregon Health and Science University, Vaccine and Gene Therapy Institute, 505 NW 185th Ave, Portland, OR 97006, USA
    J Virol 85:606-20. 2011
    b>Chikungunya virus (CHIKV) is an arthritogenic mosquito-transmitted alphavirus that is undergoing reemergence in areas around the Indian Ocean...
  43. doi Chikungunya fever in Singapore: acute clinical and laboratory features, and factors associated with persistent arthralgia
    M K Win
    Department of Clinical Epidemiology, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng 308433, Singapore mar kyaw
    J Clin Virol 49:111-4. 2010
    ..During the initial outbreak period, a strict containment strategy was adopted and all chikungunya PCR-confirmed cases were isolated and hospitalised at the designated national outbreak management centre...
  44. pmc ISG15 is critical in the control of Chikungunya virus infection independent of UbE1L mediated conjugation
    Scott W Werneke
    Department of Medicine, Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS Pathog 7:e1002322. 2011
    b>Chikungunya virus (CHIKV) is a re-emerging alphavirus that has caused significant disease in the Indian Ocean region since 2005...
  45. doi The invaders: phylogeography of dengue and chikungunya viruses Aedes vectors, on the South West islands of the Indian Ocean
    H Delatte
    Laboratoire MIVEGEC IRD 224 CNRS 5290 University of Montpellier, Institut de recherche pour le developpement IRD, Montpellier, France
    Infect Genet Evol 11:1769-81. 2011
    ....
  46. pmc Early appearance of neutralizing immunoglobulin G3 antibodies is associated with chikungunya virus clearance and long-term clinical protection
    Yiu Wing Kam
    Singapore Immunology Network, Agency for Science, Technology and Research A STAR, Singapore
    J Infect Dis 205:1147-54. 2012
    b>Chikungunya virus (CHIKV) and related arboviruses have been responsible for large epidemic outbreaks with serious economic and social impact...
  47. doi Persistent arthralgia associated with chikungunya virus: a study of 88 adult patients on reunion island
    Gianandrea Borgherini
    Service de Pneumologie et Maladies Infectieuses, Groupe Hospitalier Sud Reunion, Saint Pierre, La Reunion, France
    Clin Infect Dis 47:469-75. 2008
    An outbreak of chikungunya virus infection occurred on Reunion Island during the period 2005-2006. Persistent arthralgia after chikungunya virus infection has been reported, but few studies have treated this aspect of the disease.
  48. ncbi International diagnostic accuracy study for the serological detection of chikungunya virus infection
    M Niedrig
    Centre for Biological Safety ZBS 1, Robert Koch Institut, Berlin, Germany
    Clin Microbiol Infect 15:880-4. 2009
    External quality assurance for serological detection of chikungunya virus infection was performed to assess the diagnostic quality of expert laboratories...
  49. ncbi Understanding the alphaviruses: recent research on important emerging pathogens and progress towards their control
    E A Gould
    Institut de Recherche pour le Développement UMR190 Unité des Virus Emergents, Universite de la Mediterranee, Marseille, France
    Antiviral Res 87:111-24. 2010
    ..their classification, epidemiology and evolutionary history and the expanding geographic distribution of Chikungunya virus, we review progress in understanding the structure and function of alphavirus replicative enzymes achieved ..
  50. ncbi Chikungunya: an emerging and spreading arthropod-borne viral disease
    Francesca Cavrini
    The Emilia Romagna Regional Reference Centre for Microbiological Emergencies CRREM Unit of Microbiology, St Orsola Malpighi Hospital, University of Bologna, Bologna, Italy
    J Infect Dev Ctries 3:744-52. 2009
    ..Currently, Chikungunya is spreading in Southeast Asian aspects, clinical pictures, diagnosis and treatment of the disease caused by Chikungunya virus.
  51. pmc Multidisciplinary prospective study of mother-to-child chikungunya virus infections on the island of La Réunion
    Patrick Gerardin
    Neonatal and Pediatric Intensive Care Unit, pôle Mère Enfant, Groupe Hospitalier Sud Reunion, Saint Pierre, La Reunion, France
    PLoS Med 5:e60. 2008
    An outbreak of chikungunya virus affected over one-third of the population of La Réunion Island between March 2005 and December 2006...
  52. pmc Chikungunya virus nonstructural protein 2 inhibits type I/II interferon-stimulated JAK-STAT signaling
    Jelke J Fros
    Laboratory of Virology, Wageningen University, Droevendaalsesteeg 1, 6708 PB Wageningen, Netherlands
    J Virol 84:10877-87. 2010
    b>Chikungunya virus (CHIKV) is an emerging human pathogen transmitted by mosquitoes...
  53. pmc Concurrent chikungunya and dengue virus infections during simultaneous outbreaks, Gabon, 2007
    Eric M Leroy
    Centre International de Recherches Medicales de Franceville, Franceville, Gabon
    Emerg Infect Dis 15:591-3. 2009
    ..Chikungunya or dengue-2 virus infections were identified in 321 patients; 8 patients had documented co-infections. Aedes albopictus was identified as the principal vector for the transmission of both viruses...
  54. pmc Tracking epidemic Chikungunya virus into the Indian Ocean from East Africa
    M Kariuki Njenga
    International Emerging Infections Program Kenya, Centers for Disease Control and Prevention, Nairobi, Kenya
    J Gen Virol 89:2754-60. 2008
    The largest documented outbreak of Chikungunya virus (CHIKV) disease occurred in the Indian Ocean islands and India during 2004-2007...
  55. ncbi An animal model for studying the pathogenesis of chikungunya virus infection
    Sarah A Ziegler
    Department of Pathology and Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, Texas 77555 0609, USA
    Am J Trop Med Hyg 79:133-9. 2008
    Newborn and 14-day-old mice inoculated subcutaneously with chikungunya virus (CHIKV) developed lethargy, difficulty walking, dragging of hind limbs, and reduced weight gain within 7-10 days after infection (PI)...
  56. pmc A mouse model for Chikungunya: young age and inefficient type-I interferon signaling are risk factors for severe disease
    Thérèse Couderc
    Groupe Microorganismes et Barrières de l Hôte, Institut Pasteur, Paris, France
    PLoS Pathog 4:e29. 2008
    b>Chikungunya virus (CHIKV) is a re-emerging arbovirus responsible for a massive outbreak currently afflicting the Indian Ocean region and India...
  57. doi Chikungunya fever in the United States: a fifteen year review of cases
    Katherine B Gibney
    Arboviral Diseases Branch, Division of Vector Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado, USA
    Clin Infect Dis 52:e121-6. 2011
    b>Chikungunya virus (CHIKV) represents a threat to the United States, because humans amplify CHIKV and vectors that transmit CHIKV are present.
  58. ncbi Complete nucleotide sequence of chikungunya virus and evidence for an internal polyadenylation site
    Afjal Hossain Khan
    Department of Virology, Institute of Tropical Medicine, Nagasaki University, 1 12 4 Sakamoto, Nagasaki 852 8523, Japan
    J Gen Virol 83:3075-84. 2002
    In this study, the complete genomic sequence of chikungunya virus (CHIK; S27 African prototype) was determined and the presence of an internal polyadenylation [I-poly(A)] site was confirmed within the 3' non-translated region (NTR) of ..
  59. ncbi Tracing the path of Chikungunya virus--evolution and adaptation
    Lee Ching Ng
    Environmental Health Institute, National Environment Agency, 11, Biopolis Way, 06 05 08, Helios Block, Singapore 138667, Singapore
    Infect Genet Evol 10:876-85. 2010
    ..molecular and bioinformatics tools that have facilitated the tracing, tracking and dissection of the Chikungunya virus (CHIKV)...
  60. doi Prophylaxis and therapy for Chikungunya virus infection
    Thérèse Couderc
    Groupe Microorganismes et Barrières de l Hôte and Unité Interactions Moléculaires Flavivirus Hôtes, Centre National de Référence des Arbovirus, Institut Pasteur, INSERM, Avenir U604, and Universite Paris Descartes, Hopital Necker Enfants Malades, Paris, France
    J Infect Dis 200:516-23. 2009
    b>Chikungunya virus (CHIKV) is a recently reemerged arbovirus responsible for a massive outbreak of infection in the Indian Ocean region and India that has a very significant potential to spread globally because of the worldwide ..
  61. pmc Chikungunya fever in travelers returning to Europe from the Indian Ocean region, 2006
    Marcus Panning
    Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany
    Emerg Infect Dis 14:416-22. 2008
    ..Soon after onset of symptoms, patients had IgG and IgM and high viral loads (some >10(9) copies/mL plasma). These data will help healthcare providers select diagnostic tests for returning travelers...
  62. pmc Differential responses of the mosquito Aedes albopictus from the Indian Ocean region to two chikungunya isolates
    Estelle Martin
    Génétique Moléculaire des Bunyavirus, Institut Pasteur, 25 28 Rue du Dr Roux, Paris Cedex 15, France
    BMC Ecol 10:8. 2010
    Aedes aegypti and Aedes albopictus are both vectors of chikungunya virus (CHIKV). The two Aedes species co-exist in the Indian Ocean region and were involved in the 2005-2006 CHIKV outbreaks...
  63. pmc Chikungunya virus in North-Eastern Italy: a seroprevalence survey
    Maria Luisa Moro
    Dipartimento di Sanita Pubblica, Universita degli Studi di Bologna, Bologna, Italy
    Am J Trop Med Hyg 82:508-11. 2010
    ..Region (North-eastern Italy), a survey was performed to estimate the seroprevalence of antibody to Chikungunya virus and the proportion of asymptomatic infections, to identify factors associated with infection, and evaluate ..
  64. pmc Post-epidemic Chikungunya disease on Reunion Island: course of rheumatic manifestations and associated factors over a 15-month period
    Daouda Sissoko
    Institut de Veille Sanitaire, Cellule Interrégionale d Epidémiologie Réunion Mayotte, Direction Régionale des Affaires Sanitaires et Sociales, Saint Denis, La Reunion, France
    PLoS Negl Trop Dis 3:e389. 2009
    Although the acute manifestations of Chikungunya virus (CHIKV) illness are well-documented, few data exist about the long-term rheumatic outcomes of CHIKV-infected patients...
  65. ncbi Chikungunya: a bending reality
    Zhisheng Her
    Singapore Immunology Network, Agency for Science, Technology and Research, Immunos, Singapore
    Microbes Infect 11:1165-76. 2009
    Chikungunya fever is an acute illness caused by the arbovirus Chikungunya virus. The virus is transmitted primarily in a sylvatic cycle involving the Aedes mosquitoes...
  66. ncbi Atypical Chikungunya virus infections: clinical manifestations, mortality and risk factors for severe disease during the 2005-2006 outbreak on Réunion
    A Economopoulou
    Institute de Veille Sanitaire, France
    Epidemiol Infect 137:534-41. 2009
    ..During winter 2005, six patients developed meningoencephalitis and acute hepatitis due to Chikungunya virus. Our objectives were to determine the incidence and mortality of atypical Chikungunya viral infections and ..
  67. pmc Outbreak of dengue and Chikungunya fevers, Toamasina, Madagascar, 2006
    Mahery Ratsitorahina
    Institut Pasteur de Madagascar, Antananarivo, Madagascar
    Emerg Infect Dis 14:1135-7. 2008
    ..Aedes albopictus was the only potential vector collected. Of 4,242 randomly selected representative residents interviewed retrospectively, 67.5% reported a dengue-like syndrome during this period...
  68. doi Comparative full genome analysis revealed E1: A226V shift in 2007 Indian Chikungunya virus isolates
    S R Santhosh
    Division of Virology, Defence R and D Establishment, Gwalior, MP, India
    Virus Res 135:36-41. 2008
    The resurgence of Chikungunya virus (CHIKV) in the form of unprecedented explosive epidemic after a gap of 32 years in India is a point of major public health concern...
  69. pmc Chikungunya virus, Cameroon, 2006
    Christophe N Peyrefitte
    Institut de Medecine Tropicale du Service de Sante des Armees, Marseille, France
    Emerg Infect Dis 13:768-71. 2007
    We report the isolation of chikungunya virus from a patient during an outbreak of a denguelike syndrome in Cameroon in 2006...
  70. pmc Appearance of E1: A226V mutant Chikungunya virus in Coastal Karnataka, India during 2008 outbreak
    S R Santhosh
    Division of Virology, Defence R and D Establishment DRDE, Jhansi Road, Gwalior, MP, PIN 474 002, India
    Virol J 6:172. 2009
    ..isolation, RT-PCR and genome sequencing revealed the presence and continued circulation of A226V mutant Chikungunya virus. The appearance of this mutant virus was found to be associated with higher prevalence of vector Aedes ..
  71. pmc Biogeography of the two major arbovirus mosquito vectors, Aedes aegypti and Aedes albopictus (Diptera, Culicidae), in Madagascar
    Fara Nantenaina Raharimalala
    UMR CNRS 5557 Ecologie Microbienne, Universite Lyon 1, 43 Boulevard du 11 Novembre 1918, Villeurbanne Cedex 69622, France
    Parasit Vectors 5:56. 2012
    ..The objective of this work was to update the entomological survey of the two Aedes species in the island of Madagascar which has to face these arboviroses...
  72. pmc Prospective study of Chikungunya virus acute infection in the Island of La Réunion during the 2005-2006 outbreak
    Frederik Staikowsky
    Emergency Department, Pôle des Spécialités de l Urgence, Centre Hospitalier Régional de la Réunion, Groupe Hospitalier Sud Reunion, Saint Pierre, La Reunion, France
    PLoS ONE 4:e7603. 2009
    b>Chikungunya virus (CHIKV) is a recently re-emerged arthropod borne virus responsible for a massive outbreak in the Indian Ocean and India, and extended to Southeast Asia as well as Italy...
  73. ncbi Evaluation of recombinant E2 protein-based and whole-virus inactivated candidate vaccines against chikungunya virus
    Manish Kumar
    National Institute of Virology, Microbial Containment Complex, Sus Road, Pashan, Pune 411021, India
    Vaccine 30:6142-9. 2012
    With the re-emergence of chikungunya virus (CHIKV) in an explosive form and in the absence of a commercially available vaccine, we aimed to develop candidate vaccines employing recombinant E2 protein or chemically inactivated whole virus.
  74. pmc Chikungunya virus infection of cell lines: analysis of the East, Central and South African lineage
    Nitwara Wikan
    Institute of Molecular Biosciences, Mahidol University, Bangkok, Thailand
    PLoS ONE 7:e31102. 2012
    b>Chikungunya virus (CHIKV) is a re-emerging mosquito borne alphavirus that has caused large scale epidemics in the countries around the Indian Ocean, as well as leading to autochthonous transmission in some European countries...
  75. ncbi Vector control for the Chikungunya disease
    Yves Dumont
    CIRAD, UMR AMAP, Montpellier, F 34000, France
    Math Biosci Eng 7:313-45. 2010
    ..Based on new results on the Chikungunya virus, its impact on mosquito life-span, and several experiments done by health authorities, we studied several ..
  76. pmc Concurrent isolation of chikungunya virus and dengue virus from a patient with coinfection resulting from a trip to Singapore
    Shu Fen Chang
    Research and Diagnostic Center, Centers for Disease Control, Department of Health, 161, Kun Yang Street, Taipei, Taiwan, Republic of China
    J Clin Microbiol 48:4586-9. 2010
    ..cases of imported infection in patients who had returned to Taiwan from Singapore: one was coinfected with chikungunya virus and dengue virus type 2, and the other was infected with the same dengue virus...
  77. pmc Chikungunya virus iridocyclitis in Fuchs' heterochromic iridocyclitis
    Padmamalini Mahendradas
    Uveitis and Ocular Immunology Services, Narayana Nethralaya, Superspeciality Eye Hospital and Post Graduate Institute of Ophthalmology, 121 C, Chord Road, Rajajinagar, 1st R Block, Bangalore 560 010, Karnataka, India
    Indian J Ophthalmol 58:545-7. 2010
    We are reporting a case of bilateral Fuchs' heterochromic iridocyclitis with chikungunya virus infection in the left eye...
  78. doi Surveillance of the chikungunya vector Aedes albopictus (Skuse) in Emilia-Romagna (northern Italy): organizational and technical aspects of a large scale monitoring system
    Marco Carrieri
    Medical and Veterinary Entomology, Centro Agricoltura Ambiente G Nicoli, Crevalcore BO, Italy
    J Vector Ecol 36:108-16. 2011
    The chikungunya virus outbreak that occurred in 2007 in northern Italy (Emilia-Romagna region) prompted the development of a large scale monitoring system of the population density of Aedes albopictus (Skuse, 1894), comparable at the ..
  79. pmc Early neutralizing IgG response to Chikungunya virus in infected patients targets a dominant linear epitope on the E2 glycoprotein
    Yiu Wing Kam
    Singapore Immunology Network, Agency for Science, Technology and Research A STAR, Biopolis, Singapore
    EMBO Mol Med 4:330-43. 2012
    b>Chikungunya virus (CHIKV) and related arboviruses have been responsible for large epidemic outbreaks with serious economic and social impact. The immune mechanisms, which control viral multiplication and dissemination, are not yet known...
  80. pmc Chikungunya infection in India: results of a prospective hospital based multi-centric study
    Pratima Ray
    Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India
    PLoS ONE 7:e30025. 2012
    ..A prospective multi-centric study was conducted to evaluate clinical, epidemiological and virological features of chikugunya infection in patients with acute febrile illness from various geographical regions of India...
  81. ncbi Chikungunya: an overview
    A B Sudeep
    National Institute of Virology, 20 A, Dr Ambedkar Road, Pune 411 001, India
    J Biosci 33:443-9. 2008
    ..This review describes CHIK in general and highlights the various clinico-pathological aspects observed during the recent outbreak...
  82. doi Acute Chikungunya and persistent musculoskeletal pain following the 2006 Indian epidemic: a 2-year prospective rural community study
    A Chopra
    Centre for Rheumatic Diseases, Pune, Maharashtra, India
    Epidemiol Infect 140:842-50. 2012
    b>Chikungunya virus (CHIKV) data from population studies are sparse...
  83. ncbi Hypokalemic paralysis following Chikungunya fever
    - Rampal
    J Assoc Physicians India 55:598. 2007
  84. doi Geographic and ecological distribution of the dengue and chikungunya virus vectors Aedes aegypti and Aedes albopictus in three major Cameroonian towns
    B Kamgang
    Unité de Recherche Caractérisation et Contrôle des populations de Vecteurs CCPV, Institut de recherche pour le developpement IRD, Montpellier, France
    Med Vet Entomol 24:132-41. 2010
    ..aegypti tended to breed in containers located in environments with a high density of buildings. These findings may have important implications for vector control strategies...
  85. ncbi A serological study of Chikungunya virus transmission in Yogyakarta, Indonesia: evidence for the first outbreak since 1982
    Kevin R Porter
    Viral Diseases Program, US Naval Medical Research Unit No 2, Jakarta, Indonesia
    Southeast Asian J Trop Med Public Health 35:408-15. 2004
    A study of epidemic transmission of Chikungunya virus (CHIK) was initiated in April 1999 in Yogyakarta, Indonesia. Three hundred seventeen volunteers from three kelurahans (sub-districts) were recruited...
  86. pmc Host immune response to mosquito-transmitted chikungunya virus differs from that elicited by needle inoculated virus
    Saravanan Thangamani
    Department of Pathology, University of Texas Medical Branch, Galveston, Texas, United States of America
    PLoS ONE 5:e12137. 2010
    ..In this report, we compared host immune responses to chikungunya virus (CHIKV) transmission by (1) mosquito bite, or (2) by needle inoculation.
  87. doi Presence of the A226V mutation in autochthonous and imported Italian chikungunya virus strains
    Licia Bordi
    Clin Infect Dis 47:428-9. 2008
  88. pmc Endocytosis of chikungunya virus into mammalian cells: role of clathrin and early endosomal compartments
    Eric Bernard
    Centre d Etudes d Agents Pathogenes et Biotechnologies pour la Sante CPBS, CNRS UMR5236, Universite Montpellier 1, 2, Montpellier, France
    PLoS ONE 5:e11479. 2010
    The replicative cycle of chikungunya virus (CHIKV), an alphavirus that recently re-emerged in India and in Indian Ocean area, remains mostly unknown...
  89. pmc Chikungunya outbreak, South India, 2006
    Prabhdeep Kaur
    National Institute of Epidemiology, Chennai, India
    Emerg Infect Dis 14:1623-5. 2008
    ..Transmission was facilitated by Aedes aegypti mosquitoes in peridomestic water containers, as indicated by a high Breteau index. We recommended vector control measures and health education to promote safe water storage practices...
  90. ncbi Clinical progression of chikungunya fever during acute and chronic arthritic stages and the changes in joint morphology as revealed by imaging
    Sathya Prakash Manimunda
    Regional Medical Research Centre RMRC ICMR, Post Bag No 13, Dollygunj, Port Blair 744101, Andaman and Nicobar Islands, India
    Trans R Soc Trop Med Hyg 104:392-9. 2010
    ..The study proves with relative certainty that CHIK arthritis is chronic inflammatory erosive arthritis, which has implications for management of the infection...
  91. ncbi Immuno-biology of Chikungunya and implications for disease intervention
    Yiu Wing Kam
    Singapore Immunology Network, Agency for Science, Technology and Research, 8A Biomedical Grove, Biopolis, Singapore
    Microbes Infect 11:1186-96. 2009
    ..This review discusses what is currently known on the immuno-biology of Chikungunya and areas that will be important for the development of immune-based antiviral control strategies...
  92. doi Concurrent outbreaks of Chikungunya and Dengue fever in Kandy, Sri Lanka, 2006-07: a comparative analysis of clinical and laboratory features
    S A M Kularatne
    Department of Medicine, Faculty of Medicine, Peradeniya University, Peradeniya, Sri Lanka
    Postgrad Med J 85:342-6. 2009
    ..To compare the clinical and laboratory features of confirmed cases of Chikungunya and Dengue fever; to validate the clinical diagnosis based on serology...
  93. pmc Host alternation of chikungunya virus increases fitness while restricting population diversity and adaptability to novel selective pressures
    Lark L Coffey
    Institut Pasteur, Viral Populations and Pathogenesis, CNRS URA 3015, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
    J Virol 85:1025-35. 2011
    The mechanisms by which RNA arboviruses, including chikungunya virus (CHIKV), evolve and maintain the ability to infect vertebrate and invertebrate hosts are poorly understood...
  94. doi Chikungunya virus of Asian and Central/East African genotypes in Malaysia
    I Ching Sam
    Tropical Infectious Diseases Research and Education Centre, Department of Medical Microbiology, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia
    J Clin Virol 46:180-3. 2009
    b>Chikungunya virus (CHIKV) of the Central/East African genotype has caused large outbreaks worldwide in recent years...
  95. ncbi Inhibition of Chikungunya virus infection in cultured human muscle cells by furin inhibitors: impairment of the maturation of the E2 surface glycoprotein
    Simona Ozden
    Unité d Epidémiologie et Physiopathologie des Virus Oncogènes, CNRS URA 3015, Institut Pasteur, 75724 Paris, France
    J Biol Chem 283:21899-908. 2008
    b>Chikungunya virus (CHIKV) is a mosquito-transmitted Alphavirus that causes in humans an acute infection characterized by polyarthralgia, fever, myalgia, and headache...
  96. doi Mucocutaneous features of Chikungunya fever: a study from an outbreak in West Bengal, India
    Debabrata Bandyopadhyay
    Department of Dermatology, Venereology and Leprosy, RG Kar Medical College, Kolkata, India
    Int J Dermatol 47:1148-52. 2008
    ..Chikungunya fever (CF) epidemic has recently re-emerged in India on a large scale affecting many parts of the country. We have reviewed the mucocutaneous manifestations of the disease in a number of cases...
  97. pmc Imported Chikungunya Infection, Italy
    Anna Beltrame
    Emerg Infect Dis 13:1264-6. 2007
  98. doi Blood-feeding behavior of Aedes albopictus, a vector of Chikungunya on La Réunion
    Helene Delatte
    Research Unit 016, Institut de recherche pour le developpement IRD, Saint Pierre, France
    Vector Borne Zoonotic Dis 10:249-58. 2010
    b>Chikungunya virus (CHIKV) has long been considered to be transmitted to humans by the human-biting mosquito Aedes aegypti, especially in Africa...
  99. pmc Immunogenicity of novel consensus-based DNA vaccines against Chikungunya virus
    Karuppiah Muthumani
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Vaccine 26:5128-34. 2008
    b>Chikungunya virus (CHIKV) is an emerging arbovirus and is an important human pathogen...
  100. ncbi Chikungunya in north-eastern Italy: a summing up of the outbreak
    R Angelini
    Dipartimento Sanita Pubblica, Azienda Unita Sanitaria Locale Department of Public Health, Local Health Unit, Ravenna, Italy
    Euro Surveill 12:E071122.2. 2007
  101. ncbi On chikungunya acute infection and chloroquine treatment
    Xavier de Lamballerie
    Unite des Virus Emergents, Université de la Méditerranée and Institut de Recherche pour le Développement, Marseille, France
    Vector Borne Zoonotic Dis 8:837-9. 2008
    ..01). In conclusion, our results suggest that there is currently no justification for the use of chloroquine to treat acute chikungunya infections...

Research Grants97

  1. Mechanisms of sylvatic dengue emergence
    Scott Weaver; Fiscal Year: 2009
    ....
  2. Mechanisms of sylvatic dengue emergence
    Scott C Weaver; Fiscal Year: 2010
    ....
  3. SUPPORT FOR NATIONAL PRIMATE RESEARCH CENTER
    Joseph Robertson; Fiscal Year: 2009
    ..in Primates with Contrast Enhanced Ultrasound281Determination of Immune Correlates of Protection for Chikungunya Virus Infections245 Resource-Related Research Program Characterization of a Novel Non-Human Primate Inflammatory ..
  4. SUPPORT FOR NATIONAL PRIMATE RESEARCH CENTER
    Joseph Robertson; Fiscal Year: 2009
    ..Funding is also requested for 4 resource-related research projects and the pilot project program. Improvement and Modernization includes funds for equipment and alterations and renovations. ..
  5. Determining Molecular Mechanisms of Chikungunya Virulence and Attenuation
    KATHERINE D RYMAN; Fiscal Year: 2010
    ..b>Chikungunya virus (CHIKV) is an arbovirus, transmitted between human and non-human primates by the bite of an infected ..
  6. Determining Molecular Mechanisms of Chikungunya Virulence and Attenuation
    KATHERINE D RYMAN; Fiscal Year: 2009
    ..b>Chikungunya virus (CHIKV) is an arbovirus, transmitted between human and non-human primates by the bite of an infected ..
  7. Determining Molecular Mechanisms of Chikungunya Virulence and Attenuation
    KATHERINE RYMAN; Fiscal Year: 2009
    The Alphavirus genus, family Togaviridae, includes viruses that are significant human pathogens. Chikungunya virus (CHIKV) is an arbovirus, transmitted between human and non-human primates by the bite of an infected mosquito vector...
  8. Structure-function of alpha- and flavivirus proteins
    James Strauss; Fiscal Year: 2003
    ..and Eastern, Western, and Venezuelan equine encephalitis viruses, Ross River virus, Mayaro virus, and chikungunya virus among the alphaviruses...
  9. The Role of RNA Interference in West Nile Virus Diversification
    DOUGLAS BRACKNEY; Fiscal Year: 2009
    ..The recent epidemics of West Nile virus in North America and chikungunya virus (CHIKV) in the Eastern hemisphere highlight the potential for other arbovirus such as dengue virus (DENV) ..
  10. The Role of RNA Interference in West Nile Virus Diversification
    Douglas E Brackney; Fiscal Year: 2010
    ..The recent epidemics of West Nile virus in North America and chikungunya virus (CHIKV) in the Eastern hemisphere highlight the potential for other arbovirus such as dengue virus (DENV) ..
  11. Alphavirus Vaccines for Biodefense
    Scott Weaver; Fiscal Year: 2009
    ..b>Chikungunya virus (CHIKV) has for decades been an important but neglected cause of severe, chronic arthritis in Africa and ..
  12. Mechanisms of Chikungunya Virus Binding and Entry
    LAURIE SILVA; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Chikungunya virus (CHIKV) is an emerging mosquito-borne alphavirus responsible for recent major outbreaks of polyarthralgia in countries of the Indian Ocean region...
  13. EPIDEMIC CHIKUNGUNYA VIRUS: MOSQUITO INFECTION DETERMINANTS
    Stephen Higgs; Fiscal Year: 2009
    ..It builds upon our groups unusual expertise on chikungunya virus (CHIKV), a virus that has recently caused over 255,000 human cases in La Reunion, over 100,000 cases in ..
  14. Chimeric Alphavirus Vaccines for Chikungunya
    Scott Weaver; Fiscal Year: 2009
    b>Chikungunya virus (CHIKV), is an emerging, mosquito-borne alphavirus and potential biological weapon that has caused debilitating, chronic arthralgia in at least 2 million persons in Asia and Africa since 2005...
  15. Chimeric Alphavirus Vaccines for Chikungunya
    Scott C Weaver; Fiscal Year: 2010
    b>Chikungunya virus (CHIKV), is an emerging, mosquito-borne alphavirus and potential biological weapon that has caused debilitating, chronic arthralgia in at least 2 million persons in Asia and Africa since 2005...
  16. Mechanism and inhibition of dengue and chikungunya virus fusion protiens
    Margaret Kielian; Fiscal Year: 2009
    ..agents that are category A-C pathogens, such as the flavivirus dengue virus (DV) and the alphavirus Chikungunya virus (CV)...
  17. Development of a Novel, Chimeric Chikungunya Vaccine
    Richard Kinney; Fiscal Year: 2009
    b>Chikungunya virus (CHIKV), an emerging, mosquito-borne alphavirus and potential biological weapon that has caused debilitating and often chronic arthralgia in at least 2 million persons during the past 2 years, was recently placed on ..
  18. Pathogenesis of Arthritis and Myositis-Associated Alphaviruses
    Thomas Morrison; Fiscal Year: 2009
    Mosquito-transmitted alphaviruses, such as chikungunya virus (CHIKV) and Ross River virus (RRV), cause debilitating inflammation of joint and skeletal muscle tissue in people worldwide...
  19. Development of a Novel, Chimeric Chikungunya Vaccine
    Richard Kinney; Fiscal Year: 2009
    b>Chikungunya virus (CHIKV), an emerging, mosquito-borne alphavirus and potential biological weapon that has caused debilitating and often chronic arthralgia in at least 2 million persons during the past 2 years, was recently placed on ..
  20. Pathogenesis of Arthritis and Myositis-Associated Alphaviruses
    Thomas E Morrison; Fiscal Year: 2010
    Mosquito-transmitted alphaviruses, such as chikungunya virus (CHIKV) and Ross River virus (RRV), cause debilitating inflammation of joint and skeletal muscle tissue in people worldwide...
  21. Massively parallel sequencing of the diapause transcriptome in Aedes albopictus
    Christine Elsik; Fiscal Year: 2010
    ..albopictus (Skuse), is an important vector of dengue fever and also efficiently transmits yellow fever, chikungunya virus and several native North American arboviruses...
  22. Massively parallel sequencing of the diapause transcriptome in Aedes albopictus
    Peter Armbruster; Fiscal Year: 2009
    ..albopictus (Skuse), is an important vector of dengue fever and also efficiently transmits yellow fever, chikungunya virus and several native North American arboviruses...
  23. Live, recombinant newcastle disease virus-based vaccine against high pri pathoge
    Peter Palese; Fiscal Year: 2009
    ..on developing vaccines to three dangerous pathogens: potential pandemic influenza virus, Nipah virus, and Chikungunya virus. We will test several different strategies to improve rNDV vaccines...
  24. Development of mAb therapeutics against biothreat and emerging diease agents
    Thomas Briese; Fiscal Year: 2009
    ..engineered Veloclmmune[unreadable] mouse for producing fhmAb from recombinant antigens representing NiV and Chikungunya virus (CHIKV)...
  25. Nucleic Acids programmable Protein Array Core for Pathogenic Human Viruses
    Grant McFadden; Fiscal Year: 2009
    ..viral pathogens of interest to SERCEB and the RCE program: starting with, human coronaviruses, dengue and Chikungunya virus. The virus-specific protein microarrays will be used to screen for novel human-virus protein interactions, ..
  26. Pathogenesis of Chikungunya virus
    Mark Heise; Fiscal Year: 2009
    ..This practical approach conforms to the NIH mandate of designing vaccines and therapeutics effective against multiple agents. ..
  27. Antibody Based Therapeuticcs for Chikungunya Virus
    Michael S Diamond; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Chikungunya virus (CHIKV) is a mosquito-transmitted, single-stranded RNA alphavirus of the Togaviridae family that causes explosive epidemics of a severe febrile illness characterized by debilitating ..
  28. Pathogen-adaptable active and passive immunization platforms based on adenovirus.
    Gustavo Palacios; Fiscal Year: 2009
    ..This proposal addresses the efficacy of this technology for Chikungunya virus (CHIKV) and Nipah virus (NiV), two emerging pathogens for which no therapeutics exist...
  29. Development of a safe and effective chikungunya virus vaccine
    Danher Wang; Fiscal Year: 2009
    ..bent walker," reflecting the physique of a person suffering from the severe joint pain associated with a chikungunya virus (CHIKV) infection...
  30. Genetic Analysis of Signaling Components in Innate Immunity
    David Levy; Fiscal Year: 2009
    ..focuses on three distinct viruses that each impair the IFN pathway, influenza A virus, vaccinia virus, and chikungunya virus;will analyze the interaction between viruses and IFN signaling in a unique set of genetically modified ..
  31. B Cell Epitope Discovery: Dengue, Hepatitis C, Ebola, and Chikungunya viruses
    BENJAMIN DORANZ; Fiscal Year: 2012
    ..This contract will identify b cell epitopes for Dengue virus, Hepatitis C virus, Ebola virus, and Chikungunya virus.
  32. B Cell Epitope Discovery: Dengue, Hepatitis C, Ebola, and Chikungunya viruses
    BENJAMIN DORANZ; Fiscal Year: 2010
    ..This contract will identify b cell epitopes for Dengue virus, Hepatitis C virus, Ebola virus, and Chikungunya virus.
  33. B Cell Epitope Discovery: Dengue, Hepatitis C, Ebola, and Chikungunya viruses
    Peter Palese; Fiscal Year: 2009
    ..This contract will identify b cell epitopes for Dengue virus, Hepatitis C virus, Ebola virus, and Chikungunya virus.
  34. B Cell Epitope Discovery: Dengue, Hepatitis C, Ebola, and Chikungunya viruses
    BENJAMIN DORANZ; Fiscal Year: 2011
    ..This contract will identify b cell epitopes for Dengue virus, Hepatitis C virus, Ebola virus, and Chikungunya virus.
  35. Development of a safe and effective chikungunya virus vaccine
    Danher Wang; Fiscal Year: 2008
    ..bent walker," reflecting the physique of a person suffering from the severe joint pain associated with a chikungunya virus (CHIKV) infection...
  36. Mechanisms of sylvatic dengue emergence
    Scott Weaver; Fiscal Year: 2008
    ....
  37. Biodefense Training Program
    Scott Weaver; Fiscal Year: 2008
    ..An external advisory committee composed of outstanding, internationally recognized biodefense scientists and experienced research mentors will periodically review and guide the program through site visits. ..
  38. VEE Virus Infection on the Mosquito Vector
    Scott Weaver; Fiscal Year: 2009
    ..The results will add to our understanding of the mechanisms of epidemic VEEV emergence and provide new viral and host targets for the development of safer vaccines and novel strategies to interrupt transmission. ..
  39. VEE Virus Infection on the Mosquito Vector
    Scott C Weaver; Fiscal Year: 2010
    ..The results will add to our understanding of the mechanisms of epidemic VEEV emergence and provide new viral and host targets for the development of safer vaccines and novel strategies to interrupt transmission. ..
  40. VEE Virus Infection on the Mosquito Vector
    Scott Weaver; Fiscal Year: 2008
    ..The results will add to our understanding of the mechanisms of epidemic VEEV emergence and provide new viral and host targets for the development of safer vaccines and novel strategies to interrupt transmission. ..
  41. ECOLOGY AND GENETICS OF VENEZUELAN EQUINE ENCEPHALITIS
    Scott Weaver; Fiscal Year: 2005
    ..This information will be invaluable in targeting prevention and control resources, especially for obtaining maximum benefit in developing countries with limited resources. ..
  42. ECOLOGY AND GENETICS OF VENEZUELAN EQUINE ENCEPHALITIS
    Scott Weaver; Fiscal Year: 2002
    ..This information will be invaluable in targeting prevention and control resources, especially for obtaining maximum benefit in developing countries with limited resources. ..
  43. ECOLOGY AND GENETICS OF VENEZUELAN EQUINE ENCEPHALITIS
    Scott Weaver; Fiscal Year: 2003
    ..This information will be invaluable in targeting prevention and control resources, especially for obtaining maximum benefit in developing countries with limited resources. ..
  44. Biodefense Training Program
    Scott Weaver; Fiscal Year: 2007
    ..An external advisory committee composed of outstanding, internationally recognized biodefense scientists and experienced research mentors will periodically review and guide the program through site visits. ..
  45. ECOLOGY AND GENETICS OF VENEZUELAN EQUINE ENCEPHALITIS
    Scott Weaver; Fiscal Year: 2001
    ..This information will be invaluable in targeting prevention and control resources, especially for obtaining maximum benefit in developing countries with limited resources. ..
  46. ECOLOGY AND GENETICS OF VENEZUELAN EQUINE ENCEPHALITIS
    Scott Weaver; Fiscal Year: 2004
    ..This information will be invaluable in targeting prevention and control resources, especially for obtaining maximum benefit in developing countries with limited resources. ..
  47. ECOLOGY AND GENETICS OF VENEZUELAN EQUINE ENCEPHALITIS
    Scott Weaver; Fiscal Year: 2003
    ..This information will be invaluable in targeting prevention and control resources, especially for obtaining maximum benefit in developing countries with limited resources. ..
  48. TOGAVIRUS TROPISM FOR BONES, JOINTS, AND CNS
    Mark Heise; Fiscal Year: 2003
    ..abstract_text> ..
  49. TOGAVIRUS TROPISM FOR BONES, JOINTS, AND CNS
    Mark Heise; Fiscal Year: 2002
    ..abstract_text> ..
  50. TOGAVIRUS TROPISM FOR BONES, JOINTS, AND CNS
    Mark Heise; Fiscal Year: 2001
    ..abstract_text> ..
  51. TOGAVIRUS TROPISM FOR BONES, JOINTS, AND CNS
    Mark T Heise; Fiscal Year: 2010
    ....
  52. Immune Evasion Mechanisms of Neurovirulent Alphaviruses
    Mark T Heise; Fiscal Year: 2011
    ....
  53. TOGAVIRUS TROPISM FOR BONES, JOINTS, AND CNS
    Mark Heise; Fiscal Year: 2004
    ..abstract_text> ..
  54. Immune Evasion Mechanisms of Neurovirulent Alphaviruses
    Mark Heise; Fiscal Year: 2008
    ....
  55. Arbovirus Evasion of Type I Interferon Induction
    Mark Heise; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  56. TOGAVIRUS TROPISM FOR BONES, JOINTS, AND CNS
    Mark Heise; Fiscal Year: 2008
    ....
  57. Immune Evasion Mechanisms of Neurovirulent Alphaviruses
    Mark Heise; Fiscal Year: 2009
    ....
  58. Arbovirus Evasion of Type I Interferon Induction
    Mark Heise; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  59. Improved Vaccines for Rift Valley Fever Virus
    Mark Heise; Fiscal Year: 2008
    ....
  60. TOGAVIRUS TROPISM FOR BONES, JOINTS, AND CNS
    Mark Heise; Fiscal Year: 2007
    ....
  61. TOGAVIRUS TROPISM FOR BONES, JOINTS, AND CNS
    Mark Heise; Fiscal Year: 2009
    ....
  62. MEASLES VACCINES--IMMUNE RESPONSES AND ATYPICAL MEASLES
    Diane Griffin; Fiscal Year: 1999
    ....
  63. Improved Vaccines for Rift Valley Fever Virus
    Mark T Heise; Fiscal Year: 2010
    ....
  64. TOGAVIRUS TROPISM FOR BONES, JOINTS, AND CNS
    Mark Heise; Fiscal Year: 2009
    ....
  65. CONTROL OF ALPHAVIRUS REPLICATION IN THE NERVOUS SYSTEM
    Diane E Griffin; Fiscal Year: 2010
    ..abstract_text> ..
  66. Immune Evasion Mechanisms of Neurovirulent Alphaviruses
    Mark T Heise; Fiscal Year: 2010
    ....
  67. Improved Vaccines for Rift Valley Fever Virus
    Mark Heise; Fiscal Year: 2009
    ....
  68. ACUTE ALPHAVIRAL ENCEPHALITIS
    Diane Griffin; Fiscal Year: 1991
    ..5) To determine the relative contributions of structural and nonstructural protein coding regions of Sindbis and Ross River viruses to the development of encephalitis versus myositis in mice...
  69. ACUTE ALPHAVIRAL ENCEPHALITIS
    Diane Griffin; Fiscal Year: 1993
    ..5) To determine the relative contributions of structural and nonstructural protein coding regions of Sindbis and Ross River viruses to the development of encephalitis versus myositis in mice...
  70. GENETIC DETERMINANTS OF EPIDEMIC ALPHAVIRUS TRANSMISSION
    Stephen Higgs; Fiscal Year: 2000
    ..abstract_text> ..
  71. ACUTE ALPHAVIRUAL ENCEPHALITIS
    Diane Griffin; Fiscal Year: 2004
    ..abstract_text> ..
  72. Salivary Potentiation of Arboviral Infections
    Stephen Higgs; Fiscal Year: 2004
    ..This knowledge may contribute towards the development of a mouse model for human dengue infections. ..
  73. EPIDEMIC CHIKUNGUNYA VIRUS: MOSQUITO INFECTION DETERMINANTS
    Stephen Higgs; Fiscal Year: 2007
    ..It builds upon our groups unusual expertise on chikungunya virus (CHIKV), a virus that has recently caused over 255,000 human cases in La Reunion, over 100,000 cases in ..
  74. TRAINING:MOLECULAR & CELLULAR BASES OF INFECTIOUS DISEAS
    Diane Griffin; Fiscal Year: 2007
    ..Participation in seminars, journal clubs, the Departmental retreat, and Research Forum will also be required. ..
  75. GENETIC DETERMINANTS OF EPIDEMIC ALPHAVIRUS TRANSMISSION
    Stephen Higgs; Fiscal Year: 2001
    ..abstract_text> ..
  76. IMMUNE RESPONSE DURING MEASLES VIRUS INFECTION
    Diane Griffin; Fiscal Year: 2001
    ....
  77. TRAINING:MOLECULAR & CELLULAR BASES OF INFECTIOUS DISEAS
    Diane Griffin; Fiscal Year: 2008
    ..Participation in seminars, journal clubs, the Departmental retreat, and Research Forum will also be required. ..
  78. EPIDEMIC CHIKUNGUNYA VIRUS: MOSQUITO INFECTION DETERMINANTS
    Stephen Higgs; Fiscal Year: 2008
    ..It builds upon our groups unusual expertise on chikungunya virus (CHIKV), a virus that has recently caused over 255,000 human cases in La Reunion, over 100,000 cases in ..
  79. A Drosophila model of Batten Disease
    Robert Glaser; Fiscal Year: 2004
    ..The specific aims of the proposal are: 1. Determine the phenotypic consequences of removing DmPPT1 function by gene mutation. 2. Determine the phenotypic consequences of disrupting DmPPT1 function by RNA interference. ..
  80. Salivary Potentiation of Arboviral Infections
    Stephen Higgs; Fiscal Year: 2003
    ..This knowledge may contribute towards the development of a mouse model for human dengue infections. ..
  81. GENETIC DETERMINANTS OF EPIDEMIC ALPHAVIRUS TRANSMISSION
    Stephen Higgs; Fiscal Year: 2002
    ..abstract_text> ..
  82. Salivary Potentiation of Arboviral Infections
    Stephen Higgs; Fiscal Year: 2002
    ..This knowledge may contribute towards the development of a mouse model for human dengue infections. ..
  83. Salivary Potentiation of Arboviral Infections
    Stephen Higgs; Fiscal Year: 2001
    ..This knowledge may contribute towards the development of a mouse model for human dengue infections. ..