feline immunodeficiency virus

Summary

Summary: A species of LENTIVIRUS, subgenus feline lentiviruses (LENTIVIRUSES, FELINE) isolated from cats with a chronic wasting syndrome, presumed to be immune deficiency. There are 3 strains: Petaluma (FIP-P), Oma (FIP-O) and Puma lentivirus (PLV). There is no antigenic relationship between FIV and HIV, nor does FIV grow in human T-cells.

Top Publications

  1. pmc Pathological manifestations of feline immunodeficiency virus (FIV) infection in wild African lions
    Melody E Roelke
    Laboratory of Genomic Diversity, SAIC Frederick, Inc, NCI Frederick, Frederick, MD, USA
    Virology 390:1-12. 2009
  2. pmc Feline immunodeficiency virus (FIV) as a model for study of lentivirus infections: parallels with HIV
    John H Elder
    Department of Immunology and Microbial Sciences, The Scripps Research Institute, La Jolla, CA 92037, USA
    Curr HIV Res 8:73-80. 2010
  3. ncbi Virulence differences between two field isolates of feline immunodeficiency virus (FIV-APetaluma and FIV-CPGammar) in young adult specific pathogen free cats
    N C Pedersen
    Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    Vet Immunol Immunopathol 79:53-67. 2001
  4. ncbi Toward a detailed characterization of feline immunodeficiency virus-specific T cell immune responses and mediated immune disorders
    R Paillot
    Discovery Research, MERIAL S A S, 254 rue Marcel Mérieux BP 7009, 69342 Lyon Cedex 07, France
    Vet Immunol Immunopathol 106:1-14. 2005
  5. pmc In vivo antiretroviral activity of stampidine in chronically feline immunodeficiency virus-infected cats
    Fatih M Uckun
    Drug Discovery Program, Parker Hughes Cancer Center, St Paul, Minnesota, USA
    Antimicrob Agents Chemother 47:1233-40. 2003
  6. ncbi Combined effect of zidovudine (ZDV), lamivudine (3TC) and abacavir (ABC) antiretroviral therapy in suppressing in vitro FIV replication
    Leslie R Bisset
    Swiss National Center for Retroviruses, University of Zurich, Gloriastrasse 30, CH 8028, Zurich, Switzerland
    Antiviral Res 53:35-45. 2002
  7. pmc OrfA downregulates feline immunodeficiency virus primary receptor CD134 on the host cell surface and is important in viral infection
    Yang Hong
    Department of Immunology and Microbial Science, The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, CA 92037, USA
    J Virol 84:7225-32. 2010
  8. ncbi Functional interactions of nucleocapsid protein of feline immunodeficiency virus and cellular prion protein with the viral RNA
    Mila Moscardini
    Department of Biomedicine, University of Pisa, I 56127 Pisa, Italy
    J Mol Biol 318:149-59. 2002
  9. ncbi Mucosal administration of low-dose cell-associated feline immunodeficiency virus promotes viral latency
    Barnabe Dossou Assogba
    Department of Veterinary Biosciences, The Ohio State University, Columbus, OH 43210, USA
    J Infect Dis 195:1184-8. 2007
  10. pmc Shared usage of the chemokine receptor CXCR4 by the feline and human immunodeficiency viruses
    B J Willett
    Department of Veterinary Pathology, University of Glasgow Veterinary School, United Kingdom
    J Virol 71:6407-15. 1997

Detail Information

Publications295 found, 100 shown here

  1. pmc Pathological manifestations of feline immunodeficiency virus (FIV) infection in wild African lions
    Melody E Roelke
    Laboratory of Genomic Diversity, SAIC Frederick, Inc, NCI Frederick, Frederick, MD, USA
    Virology 390:1-12. 2009
    b>Feline immunodeficiency virus (FIV) causes AIDS in the domestic cat (Felis catus) but has not been explicitly associated with AIDS pathology in any of the eight free-ranging species of Felidae that are endemic with circulating FIV ..
  2. pmc Feline immunodeficiency virus (FIV) as a model for study of lentivirus infections: parallels with HIV
    John H Elder
    Department of Immunology and Microbial Sciences, The Scripps Research Institute, La Jolla, CA 92037, USA
    Curr HIV Res 8:73-80. 2010
    ..The following review highlights both the strengths and shortcomings of the FIV/cat model, particular as regards development of antiviral drugs...
  3. ncbi Virulence differences between two field isolates of feline immunodeficiency virus (FIV-APetaluma and FIV-CPGammar) in young adult specific pathogen free cats
    N C Pedersen
    Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    Vet Immunol Immunopathol 79:53-67. 2001
    The goal of this study was to identify a strain of feline immunodeficiency virus (FIV) that would be more virulent for adult cats than the prototype FIV-APetaluma and, thereby, enhance the FIV infection model for HIV-1 related research...
  4. ncbi Toward a detailed characterization of feline immunodeficiency virus-specific T cell immune responses and mediated immune disorders
    R Paillot
    Discovery Research, MERIAL S A S, 254 rue Marcel Mérieux BP 7009, 69342 Lyon Cedex 07, France
    Vet Immunol Immunopathol 106:1-14. 2005
    Infection of domestic cats with feline immunodeficiency virus (FIV) is associated with the development of an acquired immunodeficiency syndrome (AIDS)...
  5. pmc In vivo antiretroviral activity of stampidine in chronically feline immunodeficiency virus-infected cats
    Fatih M Uckun
    Drug Discovery Program, Parker Hughes Cancer Center, St Paul, Minnesota, USA
    Antimicrob Agents Chemother 47:1233-40. 2003
    ..reverse transcriptase inhibitor (NRTI) compound stampidine in cats chronically infected with feline immunodeficiency virus (FIV)...
  6. ncbi Combined effect of zidovudine (ZDV), lamivudine (3TC) and abacavir (ABC) antiretroviral therapy in suppressing in vitro FIV replication
    Leslie R Bisset
    Swiss National Center for Retroviruses, University of Zurich, Gloriastrasse 30, CH 8028, Zurich, Switzerland
    Antiviral Res 53:35-45. 2002
    In view of close similarities at the molecular and clinical levels, feline immunodeficiency virus (FIV) infection of the domestic cat is subject of increasing attention as an animal model for human immunodeficiency virus (HIV) infection...
  7. pmc OrfA downregulates feline immunodeficiency virus primary receptor CD134 on the host cell surface and is important in viral infection
    Yang Hong
    Department of Immunology and Microbial Science, The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, CA 92037, USA
    J Virol 84:7225-32. 2010
    b>Feline immunodeficiency virus (FIV) OrfA is an accessory protein that is critical for productive viral replication and infection in T cells...
  8. ncbi Functional interactions of nucleocapsid protein of feline immunodeficiency virus and cellular prion protein with the viral RNA
    Mila Moscardini
    Department of Biomedicine, University of Pisa, I 56127 Pisa, Italy
    J Mol Biol 318:149-59. 2002
    ..properties of the human prion protein, we set up an in vitro system to investigate replication of the feline immunodeficiency virus (FIV), which is functionally and phylogenetically distant from HIV-1...
  9. ncbi Mucosal administration of low-dose cell-associated feline immunodeficiency virus promotes viral latency
    Barnabe Dossou Assogba
    Department of Veterinary Biosciences, The Ohio State University, Columbus, OH 43210, USA
    J Infect Dis 195:1184-8. 2007
    ..To develop an animal model of host latency, cats were mucosally challenged with 10(2)-10(6) feline immunodeficiency virus (FIV)-infected T cells...
  10. pmc Shared usage of the chemokine receptor CXCR4 by the feline and human immunodeficiency viruses
    B J Willett
    Department of Veterinary Pathology, University of Glasgow Veterinary School, United Kingdom
    J Virol 71:6407-15. 1997
    b>Feline immunodeficiency virus (FIV) induces a disease state in the domestic cat that is similar to AIDS in human immunodeficiency virus (HIV)-infected individuals...
  11. ncbi Delineation of sequences important for efficient packaging of feline immunodeficiency virus RNA
    Matthew T Browning
    The University of Texas MD Anderson Cancer Center, Department of Veterinary Sciences, Bastrop, TX 78602, USA
    J Gen Virol 84:621-7. 2003
    We have used systematic deletion analysis of the 5' untranslated region (UTR) of the feline immunodeficiency virus (FIV) genome, both in the presence and absence of various amounts of gag, to define the cis-acting sequences responsible ..
  12. ncbi Structural mapping of CD134 residues critical for interaction with feline immunodeficiency virus
    Aymeric de Parseval
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Nat Struct Mol Biol 12:60-6. 2005
    CD134 is a primary binding receptor for feline immunodeficiency virus (FIV), and with CXCR4 facilitates infection of CD4(+) T cells. Human CD134 fails to support FIV infection...
  13. pmc Mapping the encapsidation determinants of feline immunodeficiency virus
    Iris Kemler
    Molecular Medicine Program, Departments of Immunology and Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Virol 76:11889-903. 2002
    ..Feline lentiviral (feline immunodeficiency virus [FIV]) encapsidation has not been studied...
  14. ncbi Prevalence of feline immunodeficiency virus and feline leukaemia virus among client-owned cats and risk factors for infection in Germany
    Sabine E Gleich
    Clinic of Small Animal Internal Medicine, Ludwig Maximilian University Munich, Veterinarstrasse 13, 80539 Munich, Germany
    J Feline Med Surg 11:985-92. 2009
    ..population in Germany by evaluation of 17,462 client-owned cats that were tested for the presence of feline immunodeficiency virus (FIV) antibodies or feline leukaemia virus (FeLV) antigen...
  15. pmc Molecular epidemiology of feline immunodeficiency virus in the domestic cat (Felis catus)
    Jessica J Hayward
    Bioinformatics Institute, Allan Wilson Centre for Molecular Ecology and Evolution, School of Biological Sciences, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand
    Vet Immunol Immunopathol 134:68-74. 2010
    Studying the evolutionary mechanisms of feline immunodeficiency virus in the domestic cat (Felis catus), FIV(Fca), provides a good comparison to other lentiviruses, such as HIV and FIV(Pco) in the cougar (Puma concolor)...
  16. doi Seroprevalences of feline leukemia virus and feline immunodeficiency virus in cats with abscesses or bite wounds and rate of veterinarian compliance with current guidelines for retrovirus testing
    Carrie E Goldkamp
    Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 32610, USA
    J Am Vet Med Assoc 232:1152-8. 2008
    ....
  17. pmc Going wild: lessons from naturally occurring T-lymphotropic lentiviruses
    Sue Vandewoude
    Department of Microbiology, Immunology and Pathology, College of Veterinary and Biomedical Sciences, Colorado State University, Fort Collins, CO 80538 1619, USA
    Clin Microbiol Rev 19:728-62. 2006
    ..more than 20 species of nondomestic felids and African hyenids demonstrate seroreactivity against feline immunodeficiency virus (FIV) antigens...
  18. pmc Vif of feline immunodeficiency virus from domestic cats protects against APOBEC3 restriction factors from many felids
    Jörg Zielonka
    Clinic for Gastroenterology, Hepatology and Infectiology, Heinrich Heine University, Building 23 12 U1 87, Moorenstr 5, 40225 Dusseldorf, Germany
    J Virol 84:7312-24. 2010
    ..more insight into the role of APOBEC3 (A3) cytidine deaminases in the species-specific restriction of feline immunodeficiency virus (FIV) of the domestic cat, we tested the A3 proteins present in big cats (puma, lion, tiger, and lynx)...
  19. pmc Seroprevalence of feline leukemia virus and feline immunodeficiency virus infection among cats in Canada
    Susan Little
    Bytown Cat Hospital, 422 McArthur Ave, Ottawa, Ontario K1K 1G6, Canada
    Can Vet J 50:644-8. 2009
    The purposes of this study were to determine the seroprevalence of feline leukemia virus (FeLV) and feline immunodeficiency virus (FIV) infection among cats in Canada and to identify risk factors for seropositivity...
  20. ncbi Feline leukaemia virus (FeLV) and feline immunodeficiency virus infections in cats in the Pisa district of Tuscany, and attempts to control FeLV infection in a colony of domestic cats by vaccination
    P Bandecchi
    Dipartimento di Patologia Animale, Profilassi ed Igiene degli Alimenti, Universita di Pisa, Viale delle Piagge 2, 56100 Pisa, Italy
    Vet Rec 158:555-7. 2006
    The seroprevalence of feline immunodeficiency virus (FIV) in 203 apparently healthy domestic cats living in the district of Pisa, central Italy, was 11.3 per cent, and the prevalence of feline leukaemia virus (FeLV) was 8.4 per cent...
  21. pmc Preferential feline immunodeficiency virus (FIV) infection of CD4+ CD25+ T-regulatory cells correlates both with surface expression of CXCR4 and activation of FIV long terminal repeat binding cellular transcriptional factors
    Anjali Joshi
    Immunology Program, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina 27606, USA
    J Virol 79:4965-76. 2005
    ..T-regulatory (Treg) cells with regard to their immune regulatory properties and ability to support feline immunodeficiency virus (FIV) replication in vitro and in vivo...
  22. pmc Feline immunodeficiency virus neuropathogenesis: from cats to calcium
    Rick B Meeker
    Department of Neurology, University of North Carolina, CB 7025, 6109F Neuroscience Research Bldg, Chapel Hill, NC 27599, USA
    J Neuroimmune Pharmacol 2:154-70. 2007
    ..made from in vitro and in vivo studies on the infectious and pathological interactions of feline immunodeficiency virus (FIV) with the nervous system...
  23. pmc Genetically divergent strains of feline immunodeficiency virus from the domestic cat (Felis catus) and the African lion (Panthera leo) share usage of CD134 and CXCR4 as entry receptors
    William A McEwan
    Faculty of Veterinary Medicine, Retrovirus Research Laboratory, Institute of Comparative Medicine, University of Glasgow, Bearsden Road, Glasgow, United Kingdom
    J Virol 82:10953-8. 2008
    The env open reading frames of African lion (Panthera leo) lentivirus (feline immunodeficiency virus [FIV(Ple)]) subtypes B and E from geographically distinct regions of Africa suggest two distinct ancestries, with FIV(Ple)-E sharing a ..
  24. pmc Human gene therapy vectors derived from feline lentiviruses
    Román A Barraza
    Molecular Medicine Program, Guggenheim 18, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, United States
    Vet Immunol Immunopathol 123:23-31. 2008
    Lentiviral vectors are useful for gene transfer to dividing and nondividing cells. Feline immunodeficiency virus (FIV) vectors transduce most human cell types with good efficiency and may have advantages for clinical gene therapy ..
  25. pmc Immunohistochemical localization of feline immunodeficiency virus using native species antibodies
    Arlin B Rogers
    Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, Colorado 80523 1674, USA
    Am J Pathol 161:1143-51. 2002
    b>Feline immunodeficiency virus (FIV) is the feline analog of human immunodeficiency virus and a small animal model of human acquired immune deficiency syndrome (AIDS)...
  26. doi Antiviral activity of membrane fusion inhibitors that target gp40 of the feline immunodeficiency virus envelope protein
    Fuminori Mizukoshi
    Department of Veterinary Internal Medicine, The University of Tokyo, Bunkyo ku, Tokyo 113 8657, Japan
    Vet Microbiol 136:155-9. 2009
    ..to examine the inhibitory effect of modified peptides corresponding to heptad repeats (HR) 1 and 2 of feline immunodeficiency virus (FIV) envelope gp40 on the fusion between the viral and cellular membranes...
  27. pmc Neonatal gene therapy of glycogen storage disease type Ia using a feline immunodeficiency virus-based vector
    Albert Grinshpun
    Goldyne Savad Institute of Gene Therapy, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Mol Ther 18:1592-8. 2010
    ..Vectors have been constructed from feline immunodeficiency virus (FIV), a nonprimate lentivirus, because the wild-type virus does not cause disease in humans...
  28. pmc RNA secondary structure of the feline immunodeficiency virus 5'UTR and Gag coding region
    Laurie James
    CNRS UPR2167 Centre de Génétique Moléculaire, Avenue de la Terrasse, 91190 Gif sur Yvette, France
    Nucleic Acids Res 36:4653-66. 2008
    ..into the structure-function relationship of lentiviral 5'UTRs, we modelled the RNA structure of the feline immunodeficiency virus (FIV), a virus that is evolutionarily distant from the primate viruses...
  29. pmc Cytokine response in multiple lymphoid tissues during the primary phase of feline immunodeficiency virus infection
    G A Dean
    Department of Microbiology, Pathology, and Parasitology, North Carolina State University, Raleigh, North Carolina 27606, USA
    J Virol 72:9436-40. 1998
    ..various time periods and in various lymphoid compartments during the acute stage (first 4 months) of feline immunodeficiency virus (FIV) infection in laboratory cats. Cytokine responses were correlated with virus replication...
  30. ncbi Feline immunodeficiency virus infection phenotypically and functionally activates immunosuppressive CD4+CD25+ T regulatory cells
    Thomas W Vahlenkamp
    Immunology Program, North Carolina State University, Raleigh, NC 27606, USA
    J Immunol 172:4752-61. 2004
    Disease progression of feline immunodeficiency virus (FIV) infection is characterized by up-regulation of B7.1 and B7.2 costimulatory molecules and their ligand CTLA4 on CD4(+) and CD8(+) T cells...
  31. ncbi Seroprevalence of feline leukemia virus and feline immunodeficiency virus infection among cats in North America and risk factors for seropositivity
    Julie K Levy
    Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 32610 0126, USA
    J Am Vet Med Assoc 228:371-6. 2006
    ..To determine seroprevalence of FeLV and FIV infection among cats in North America and risk factors for seropositivity...
  32. ncbi Pre-existing immunity to pathogenic Listeria monocytogenes does not prevent induction of immune responses to feline immunodeficiency virus by a novel recombinant Listeria monocytogenes vaccine
    Rosemary Stevens
    Department of Microbiology, Pathology and Parasitology, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
    Vaccine 23:1479-90. 2005
    ..The FIV/cat model will provide a useful challenge system to determine whether recombinant L. monocytogenes can protect against a lentivirus in its natural host after challenge by the routes common to HIV transmission...
  33. pmc Feline immunodeficiency virus (FIV) in wild Pallas' cats
    Meredith A Brown
    Laboratory of Genomic Diversity, National Cancer Institute Frederick, Frederick, MD 21702, USA
    Vet Immunol Immunopathol 134:90-5. 2010
    b>Feline immunodeficiency virus (FIV), a feline lentivirus related to HIV, causes immune dysfunction in domestic and wild cats...
  34. ncbi Phylogenetic analysis to define feline immunodeficiency virus subtypes in 31 domestic cats in South Africa
    R Kann
    School of Veterinary Science, University of Queensland, St Lucia, Queensland, 4072, Australia
    J S Afr Vet Assoc 77:108-13. 2006
    b>Feline immunodeficiency virus (FIV), a lentivirus, is an important pathogen of domestic cats around the world and has many similarities to human immunodeficiency virus (HIV)...
  35. ncbi A feline immunodeficiency virus vif-deletion mutant remains attenuated upon infection of newborn kittens
    Xiaoying Shen
    Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    J Gen Virol 88:2793-9. 2007
    ..attenuation associated with a vif mutation by inoculation of newborn kittens with a vif-deleted feline immunodeficiency virus provirus plasmid (FIV-pPPRDeltavif)...
  36. ncbi Intrahost evolution of envelope glycoprotein and OrfA sequences after experimental infection of cats with a molecular clone and a biological isolate of feline immunodeficiency virus
    Willem Huisman
    Erasmus MC, Institute of Virology, Rotterdam, The Netherlands
    Virus Res 137:24-32. 2008
    b>Feline immunodeficiency virus (FIV) is a member of the genus Lentivirus and causes AIDS-like disease in its natural host, the cat...
  37. ncbi Molecular subtyping of feline immunodeficiency virus from domestic cats in Australia
    R K C Kann
    School of Veterinary Science, University of Queensland, Queensland
    Aust Vet J 84:112-6. 2006
    To determine the prevalent subtypes of feline immunodeficiency virus (FIV) present in the domestic cat population of Australia.
  38. ncbi Phylogenetic analysis of Vietnamese isolates of feline immunodeficiency virus: genetic diversity of subtype C
    K Nakamura
    Department of Veterinary Microbiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan
    Arch Virol 148:783-91. 2003
    Phylogenetic relationships of novel Vietnamese strains of feline immunodeficiency virus (FIV) were analysed...
  39. ncbi Mutational analysis of the feline immunodeficiency virus matrix protein
    M L Manrique
    , Serrano 669, C1414DEM, Buenos Aires, Argentina
    Virus Res 76:103-13. 2001
    To study the process of feline immunodeficiency virus (FIV) assembly, we examined the suitability of the vaccinia vector system to reproduce FIV particle formation...
  40. ncbi High genetic stability of TM1 and TM2 strains of subtype B feline immunodeficiency virus in long-term infection
    Yasuhiro Ikeda
    Department of Veterinary Microbiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Japan
    J Vet Med Sci 66:287-9. 2004
    To know the genetic changes of feline immunodeficiency virus (FIV) in long-term infection in cats, we inoculated three specific pathogen-free cats with FIV isolates and determined a partial env sequence covering the V3-V5 region...
  41. pmc Modulation of the virus-receptor interaction by mutations in the V5 loop of feline immunodeficiency virus (FIV) following in vivo escape from neutralising antibody
    Brian J Willett
    Retrovirus Research Laboratory, Institute of Comparative Medicine, Faculty of Veterinary Medicine, University of Glasgow, Bearsden Road, Glasgow, UK
    Retrovirology 7:38. 2010
    In the acute phase of infection with feline immunodeficiency virus (FIV), the virus targets activated CD4+ T cells by utilising CD134 (OX40) as a primary attachment receptor and CXCR4 as a co-receptor...
  42. ncbi Use of CD134 as a primary receptor by the feline immunodeficiency virus
    Masayuki Shimojima
    Department of Veterinary Microbiology, Graduate School of Agricultural and Life Sciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Science 303:1192-5. 2004
    b>Feline immunodeficiency virus (FIV) induces a disease similar to acquired immunodeficiency syndrome (AIDS) in cats, yet in contrast to human immunodeficiency virus (HIV), CD4 is not the viral receptor...
  43. pmc Lentivirus-induced immune dysregulation
    Mary B Tompkins
    Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, United States
    Vet Immunol Immunopathol 123:45-55. 2008
    ..As such, the natural history and pathogenesis provides an excellent model to study the long-term relationships between AIDS lentivirus and host immune system function/dysregulation...
  44. doi Feline immunodeficiency virus env gene evolution in experimentally infected cats
    Martin Kraase
    Retrovirus Research Laboratory, Institute of Comparative Medicine, Faculty of Veterinary Medicine, University of Glasgow, Bearsden Road, Glasgow G61 1QH, United Kingdom
    Vet Immunol Immunopathol 134:96-106. 2010
    b>Feline immunodeficiency virus (FIV), an immunosuppressive lentivirus found in cats worldwide, is studied to illuminate mechanisms of lentiviral pathogenesis and to identify key components of protective immunity...
  45. pmc A dormant internal ribosome entry site controls translation of feline immunodeficiency virus
    Valentina Camerini
    Ecole Normale Superieure de Lyon, Unité de Virologie Humaine, IFR 128, Lyon F 69364, France
    J Virol 82:3574-83. 2008
    ..entry sites (IRESs) in virtually all lentiviruses prompted us to investigate the mechanism used by the feline immunodeficiency virus (FIV) to produce viral proteins...
  46. pmc Feline immunodeficiency virus ORF-Ais required for virus particle formation and virus infectivity
    Malou C Gemeniano
    Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, California 95616, USA
    J Virol 77:8819-30. 2003
    The orf-A (orf-2) gene of feline immunodeficiency virus (FIV) is a small open reading frame predicted to encode a 77-amino-acid protein that contains putative domains similar to those of the ungulate lentiviral Tat protein...
  47. pmc Feline immunodeficiency virus OrfA is distinct from other lentivirus transactivators
    Udayan Chatterji
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Virol 76:9624-34. 2002
    The feline immunodeficiency virus (FIV) accessory factor, OrfA, facilitates transactivation of transcription directed by elements of the viral long terminal repeat (LTR)...
  48. ncbi The critical role of proximal gag sequences in feline immunodeficiency virus genome encapsidation
    Iris Kemler
    Molecular Medicine Program, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Virology 327:111-20. 2004
    ..b>Feline immunodeficiency virus (FIV) RNA encapsidation determinants have been shown to be discrete and noncontinuous, comprising one ..
  49. pmc Evolution of replication efficiency following infection with a molecularly cloned feline immunodeficiency virus of low virulence
    Margaret J Hosie
    Department of Veterinary Pathology, University of Glasgow, Glasgow G61 1QH, United Kingdom
    J Virol 76:6062-72. 2002
    ..with the domestic cat have demonstrated that vaccinal immunity to infection can be induced against feline immunodeficiency virus (FIV); however, protection is largely restricted to laboratory strains of FIV and does not extend to ..
  50. pmc Phylogenetic and genetic analysis of feline immunodeficiency virus gag, pol, and env genes from domestic cats undergoing nucleoside reverse transcriptase inhibitor treatment or treatment-naïve cats in Rio de Janeiro, Brazil
    Angelica N Martins
    Laboratory of Molecular Virology, Department of Genetics, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil
    J Virol 82:7863-74. 2008
    b>Feline immunodeficiency virus (FIV) is the Lentivirus responsible for an immunodeficiency-like disease in domestic cats (Felis catus). FIV is divided into five phylogenetic subtypes (A, B, C, D, and E), based on genetic diversity...
  51. pmc Acute mucosal pathogenesis of feline immunodeficiency virus is independent of viral dose in vaginally infected cats
    Kristina E Howard
    Center for Comparative Medicine and Translational Research, Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA
    Retrovirology 7:2. 2010
    ..The objective of this study was to determine the acute effect of viral dose on mucosal leukocytes and associated innate and adaptive immune responses...
  52. ncbi Downmodulation of CD3epsilon expression in CD8alpha+beta- T cells of feline immunodeficiency virus-infected cats
    Yorihiro Nishimura
    Department of Veterinary Microbiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    J Gen Virol 85:2585-9. 2004
    b>Feline immunodeficiency virus (FIV) infection in cats is associated with an increase of feline CD (fCD)8alpha+beta- and fCD8alpha+beta low cells in peripheral blood...
  53. ncbi Methamphetamine enhances cell-associated feline immunodeficiency virus replication in astrocytes
    Mikhail A Gavrilin
    Department of Veterinary Clinical Sciences, College of Veterinary Medicine The Ohio State University, Columbus 43230, USA
    J Neurovirol 8:240-9. 2002
    ..Many Lentivirinae, including feline immunodeficiency virus (FIV), penetrate into the central nervous system early in the course of infection with astrocytes ..
  54. pmc Maternal hematological and virological characteristics during early feline immunodeficiency virus (FIV) infection of cats as predictors of fetal infection and reproductive outcome at early gestation
    Crystal E Boudreaux
    Department of Biological Sciences, Mississippi State University, Mississippi State, MS 39762, USA
    Vet Immunol Immunopathol 131:290-7. 2009
    ..However, maternal virological and hematological characteristics did not correlate either positively or negatively with reproductive outcome...
  55. pmc Feline immunodeficiency virus model for designing HIV/AIDS vaccines
    Janet K Yamamoto
    Department of Infectious Diseases and Pathology, College of Veterinary Medicine, University of Florida, P O Box 110880, Gainesville, FL 32611, USA
    Curr HIV Res 8:14-25. 2010
    b>Feline immunodeficiency virus (FIV) discovered in 1986 is a lentivirus that causes AIDS in domestic cats...
  56. ncbi Effect of feline immunodeficiency virus on cytokine response to Listeria monocytogenes in vivo
    G A Dean
    Department of Microbiology, Pathology, and Parasitology, College of Veterinary Medicine, North Carolina State University, Raleigh 27606, USA
    Vet Immunol Immunopathol 65:125-38. 1998
    b>Feline immunodeficiency virus (FIV) is a lentivirus that induces an acquired immunodeficiency in domestic cats...
  57. pmc In vivo depletion of CD4(+)CD25(hi) regulatory T cells is associated with improved antiviral responses in cats chronically infected with feline immunodeficiency virus
    S Rochelle Mikkelsen
    College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA
    Virology 403:163-72. 2010
    ..Lentivirus-induced CD4(+)CD25(hi) Treg cells were first described in feline immunodeficiency virus (FIV)-infected cats...
  58. ncbi CD134 and CXCR4 expression corresponds to feline immunodeficiency virus infection of lymphocytes, macrophages and dendritic cells
    F Reggeti
    Department of Pathobiology, University of Guelph, Guelph, ON N1G 2W1, Canada
    J Gen Virol 89:277-87. 2008
    The lymphotropic lentiviruses feline immunodeficiency virus (FIV) and human immunodeficiency virus (HIV) enter cells by sequential interaction with primary receptors CD134 or CD4, respectively, and subsequently with chemokine receptors...
  59. ncbi Natural antisense transcripts are detected in different cell lines and tissues of cats infected with feline immunodeficiency virus
    S Briquet
    INSERM U511, , , 75013 Paris, France
    Gene 267:157-64. 2001
    b>Feline immunodeficiency virus (FIV) is a lentivirus inducing an AIDS-like disease in cats, thus providing an interesting model for AIDS study...
  60. pmc Compartmentalization and evolution of feline immunodeficiency virus between the central nervous system and periphery following intracerebroventricular or systemic inoculation
    Pinghuang Liu
    Immunology Program, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, USA
    J Neurovirol 12:307-21. 2006
    ..c.v.) or intraperitoneal (i.p.) inoculation of animals with cell-free feline immunodeficiency virus (FIV)...
  61. pmc Antiviral activity and conformational features of an octapeptide derived from the membrane-proximal ectodomain of the feline immunodeficiency virus transmembrane glycoprotein
    Simone Giannecchini
    Retrovirus Center and Virology Section, Department of Experimental Pathology, University of Pisa, I 56127 Pisa, Italy
    J Virol 77:3724-33. 2003
    b>Feline immunodeficiency virus (FIV) provides a valuable animal model by which criteria for lentivirus control strategies can be tested...
  62. pmc Molecular characterization of feline immunodeficiency virus budding
    Benjamin G Luttge
    Virus Cell Interaction Section, HIV Drug Resistance Program, NCI Frederick, Bldg 535, RM 108, Frederick, MD 21702 1201, USA
    J Virol 82:2106-19. 2008
    Infection of domestic cats with feline immunodeficiency virus (FIV) is an important model system for studying human immunodeficiency virus type 1 (HIV-1) infection due to numerous similarities in pathogenesis induced by these two ..
  63. pmc Cerebrospinal fluid is an efficient route for establishing brain infection with feline immunodeficiency virus and transfering infectious virus to the periphery
    Pinghuang Liu
    Immunology Program, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, USA
    J Neurovirol 12:294-306. 2006
    Like human immunodeficiency virus (HIV), feline immunodeficiency virus (FIV) invades and infects the central nervous system (CNS) soon after peripheral infection...
  64. ncbi Nonpathogenic lion and puma lentiviruses impart resistance to superinfection by virulent feline immunodeficiency virus
    Sue Vandewoude
    Department of Pathology, Colorado State University, Fort Collins, Colorado 80523 1671, USA
    J Acquir Immune Defic Syndr 29:1-10. 2002
    ..The feline immunodeficiency virus (FIV) is highly divergent from LLV and PLV and is pathogenic for domestic cats...
  65. pmc A single site for N-linked glycosylation in the envelope glycoprotein of feline immunodeficiency virus modulates the virus-receptor interaction
    Brian J Willett
    Retrovirus Research Laboratory, Institute of Comparative Medicine, Faculty of Veterinary Medicine, University of Glasgow, Bearsden Road, Glasgow, G61 1QH, UK
    Retrovirology 5:77. 2008
    b>Feline immunodeficiency virus (FIV) targets helper T cells by attachment of the envelope glycoprotein (Env) to CD134, a subsequent interaction with CXCR4 then facilitating the process of viral entry...
  66. doi Neutralization of feline immunodeficiency virus by antibodies targeting the V5 loop of Env
    Ayman Samman
    Retrovirus Research Laboratory, Institute of Comparative Medicine, Faculty of Veterinary Medicine, University of Glasgow, Bearsden, Glasgow G61 1QH, UK
    J Gen Virol 91:242-9. 2010
    Neutralizing antibodies (NAbs) play a vital role in vaccine-induced protection against infection with feline immunodeficiency virus (FIV)...
  67. pmc AIDS vaccination studies using an ex vivo feline immunodeficiency virus model: protection from an intraclade challenge administered systemically or mucosally by an attenuated vaccine
    Mauro Pistello
    Retrovirus Center and Virology Section, Department of Experimental Pathology, University of Pisa, Pisa, Italy
    J Virol 77:10740-50. 2003
    b>Feline immunodeficiency virus (FIV) infection of domestic cats represents a valuable system through which to investigate criteria for antilentiviral vaccines in a natural host species...
  68. ncbi Bold attitude makes male urban feral domestic cats more vulnerable to Feline Immunodeficiency Virus
    Eugenia Natoli
    Azienda USL Roma D, Area Dipartimentale Sanita Pubblica veterinaria, Ospedale Veterinario, via della Magliana 856, 00148 Roma, Italy
    Neurosci Biobehav Rev 29:151-7. 2005
    ..a high annual reproductive success but, on the other hand, to a high probability to be infected by the Feline Immunodeficiency Virus (FIV), a lethal disease caused by a retrovirus...
  69. pmc C-Terminal gp40 peptide analogs inhibit feline immunodeficiency virus: cell fusion and virus spread
    R J Medinas
    Immunology Program, North Carolina State University, Raleigh 27606, USA
    J Virol 76:9079-86. 2002
    ..b>Feline immunodeficiency virus (FIV) infection in the cat has been used as a model to develop potential antivirals for HIV...
  70. ncbi Evidence of feline immunodeficiency virus, feline leukemia virus, and Toxoplasma gondii in feral cats on Mauna Kea, Hawaii
    Raymond M Danner
    Pacific Cooperative Studies Unit, University of Hawaii at Manoa, c o USGS Pacific Island Ecosystems Research Center, Kilauea Field Station, Hawaii National Park, HI 96718, USA
    J Wildl Dis 43:315-8. 2007
    We determined prevalence to feline immunodeficiency virus (FIV) antibodies, feline leukemia virus (FeLV) antigen, and Toxoplasma gondii antibodies in feral cats (Felis catus) on Mauna Kea Hawaii from April 2002 to May 2004. Six of 68 (8...
  71. ncbi Domestic cats infected with lion or puma lentivirus develop anti-feline immunodeficiency virus immune responses
    Sue Vandewoude
    Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, 80523 1619, USA
    J Acquir Immune Defic Syndr 34:20-31. 2003
    ..PLV) or lion lentivirus (LLV) conferred partial protection against superinfection with virulent feline immunodeficiency virus (FIV), the feline equivalent of HIV...
  72. ncbi Plasma electrophoretogram in feline immunodeficiency virus (FIV) and/or feline leukaemia virus (FeLV) infections
    G Miro
    Departamento de Sanidad Animal, Facultad de Veterinaria, Universidad Complutense, Madrid, Spain
    J Vet Med A Physiol Pathol Clin Med 54:203-9. 2007
    The electrophoretogram of 89 cats, including those infected by feline immunodeficiency virus (FIV+), feline leukaemia virus (FeLV+) and non-infected, showed statistically significant differences in several of the fractions...
  73. ncbi Mucosal infection and vaccination against feline immunodeficiency virus
    C R Stokes
    Division of Molecular and Cellular Biology, University of Bristol, UK
    J Biotechnol 73:213-21. 1999
    b>Feline immunodeficiency virus (FIV) infection is a naturally occurring lentiviral infection of cats which progresses to immunodeficiency in a manner strikingly similar to that observed in HIV infection in man...
  74. ncbi Inhibitory RNA ligand to reverse transcriptase from feline immunodeficiency virus
    H Chen
    Department of Molecular, University of Colorado at Boulder 80309, USA
    Biochemistry 35:6923-30. 1996
    High-affinity, high-specificity RNA ligands for reverse transcriptase from feline immunodeficiency virus (FIV) were isolated from an RNA library by the SELEX (Systematic Evolution of Ligands by EXponential enrichment) procedure...
  75. ncbi Feline immunodeficiency virus plasma load reduction by a retroinverso octapeptide reproducing the Trp-rich motif of the transmembrane glycoprotein
    Simone Giannecchini
    Retrovirus Centre and Virology Section, Department of Experimental Pathology, University of Pisa, Pisa, Italy
    Antivir Ther 10:671-80. 2005
    ..We recently demonstrated that an octapeptide reproducing the TrpM of feline immunodeficiency virus (FIV), designated C8, broadly inhibited this virus in vitro and that the retroinverso analogue of this ..
  76. pmc Optimization of feline immunodeficiency virus vectors for RNA interference
    Scott Q Harper
    Program in Gene Therapy, University of Iowa, Iowa City, IA 52242, USA
    J Virol 80:9371-80. 2006
    ..Here, we tested the hypothesis that vectors based on feline immunodeficiency virus (FIV) could be used for coexpression of reporter constructs and RNAi expression cassettes...
  77. ncbi Feline immunodeficiency virus integration in B-cell lymphoma identifies a candidate tumor suppressor gene on human chromosome 15q15
    Julia Beatty
    Molecular Oncology Laboratory, Institute of Comparative Medicine, University of Glasgow Veterinary School, Bearsden, Glasgow, Scotland
    Cancer Res 62:7175-80. 2002
    ..An exception wasfound in a B-cell lymphoma (Q254) where the tumor cells contained a single integrated feline immunodeficiency virus genome...
  78. pmc Temporal association of large granular lymphocytosis, neutropenia, proviral load, and FasL mRNA in cats with acute feline immunodeficiency virus infection
    W S Sprague
    Colorado State University, Department of Microbiology, Immunology and Pathology, 1600 Campus Delivery, Fort Collins, CO, USA
    Vet Immunol Immunopathol 134:115-21. 2010
    During acute feline immunodeficiency virus-C(PGammar) (FIV-C-PG) infection, we observed that cats develop large granular lymphocyte (LGL) lymphocytosis concurrent with a marked neutropenia that is temporally associated with the rise and ..
  79. ncbi Constitutive expression of types 1 and 2 cytokines by alveolar macrophages from feline immunodeficiency virus-infected cats
    J W Ritchey
    Department of Microbiology, Pathology, and Parasitology, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, 27606, Raleigh, NC, USA
    Vet Immunol Immunopathol 79:83-100. 2001
    Evidence suggests that feline immunodeficiency virus (FIV), causes pulmonary immunodeficiency...
  80. ncbi Lymphocyte migration through the blood-brain barrier (BBB) in feline immunodeficiency virus infection is significantly influenced by the pre-existence of virus and tumour necrosis factor (TNF)-alpha within the central nervous system (CNS): studies using a
    N F Fletcher
    University College Dublin, Ireland
    Neuropathol Appl Neurobiol 35:592-602. 2009
    ..Some knowledge exists on macrophage-tropic virus interactions with the blood-brain barrier (BBB), and the aim of this study was to investigate lymphotropic lentivirus interactions with the BBB...
  81. ncbi Feline immunodeficiency virus-mediated viral interleukin-10 gene transfer prolongs non-vascularized cardiac allograft survival
    Shuang Fu
    Carl C Icahn Institute for Gene Therapy and Molecular Medicine, and Recanati Miller Transplantation Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    Am J Transplant 3:552-61. 2003
    ..b>Feline immunodeficiency virus (FIV) can integrate into genomic DNA of nondividing cells, resulting in indefinite transgene ..
  82. ncbi TNF-alpha-induced cell death in feline immunodeficiency virus-infected cells is mediated by the caspase cascade
    T Mizuno
    Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo, 113 8657, Japan
    Virology 287:446-55. 2001
    ..The present study indicates that TNF-alpha-induced apoptosis in FIV-infected CRFK cells is mediated by the activation of the caspase cascade, but not by either upregulation of TNF receptor or inhibition of NF-kappaB...
  83. pmc The secondary structure of the 5' end of the FIV genome reveals a long-range interaction between R/U5 and gag sequences, and a large, stable stem-loop
    Julia C Kenyon
    Department of Medicine, Addenbrooke s Hospital, University of Cambridge, Cambridge CB2 2QQ, United Kingdom
    RNA 14:2597-608. 2008
    b>Feline immunodeficiency virus (FIV) is a lentivirus that infects cats and is related to human immunodeficiency virus (HIV)...
  84. pmc Neurovirulence in feline immunodeficiency virus-infected neonatal cats is viral strain specific and dependent on systemic immune suppression
    C Power
    Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta T2N 4N1 Canada
    J Virol 72:9109-15. 1998
    b>Feline immunodeficiency virus (FIV) is a lentivirus that causes immune suppression and neurological disease in cats...
  85. ncbi Evaluation of the association of Bartonella species, feline herpesvirus 1, feline calicivirus, feline leukemia virus and feline immunodeficiency virus with chronic feline gingivostomatitis
    Jessica M Quimby
    College of Veterinary Medicine and Biomedical Sciences, Colorado State University, 300 West Drake Road, Fort Collins, CO 80523, USA
    J Feline Med Surg 10:66-72. 2008
    ..Serum was tested for feline leukemia virus (FeLV) antigen and antibodies against feline immunodeficiency virus, feline calicivirus (FCV), feline herpesvirus 1 (FHV-1), and Bartonella species (enzyme-linked ..
  86. pmc Antiretroviral spermicide WHI-07 prevents vaginal and rectal transmission of feline immunodeficiency virus in domestic cats
    OSMOND J D'CRUZ
    Drug Discovery Program, Parker Hughes Institute, St Paul, Minnesota 55113, USA
    Antimicrob Agents Chemother 48:1082-8. 2004
    ..WHI-07 was active against the feline immunodeficiency virus (FIV)...
  87. ncbi The feline immunodeficiency virus-infected cat: a model for lentivirus-induced placental immunopathology and reproductive failure (mini-review)
    Karen S Coats
    Department of Biological Sciences and College of Veterinary Medicine, Mississippi State University, PO Box GY, MS 39762, USA
    Am J Reprod Immunol 54:169-85. 2005
    ..Transplacental transmission is readily achieved experimentally, resulting in a high proportion of infected offspring and frequent reproductive failure...
  88. ncbi Cytokine modulation of the innate immune response in feline immunodeficiency virus-infected cats
    Gregg A Dean
    Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, 27606, USA
    J Infect Dis 193:1520-7. 2006
    ..b>Feline immunodeficiency virus (FIV) infection in cats provides an excellent model to explore innate immune function in vivo...
  89. doi Design and synthesis of membrane fusion inhibitors against the feline immunodeficiency virus
    Shinya Oishi
    Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    Bioorg Med Chem 17:4916-20. 2009
    b>Feline immunodeficiency virus (FIV) is a pathogenic virus that causes an AIDS-like syndrome in the domestic cats...
  90. ncbi Molecular characteristics of malignant lymphomas in cats naturally infected with feline immunodeficiency virus
    Y Endo
    Department of Veterinary Internal Medicine, Faculty of Agriculture, University of Tokyo, Japan
    Vet Immunol Immunopathol 57:153-67. 1997
    Neoplastic disease, especially malignant lymphomas, are often observed in cats infected with feline immunodeficiency virus (FIV)...
  91. pmc Dynamics of viral and proviral loads of feline immunodeficiency virus within the feline central nervous system during the acute phase following intravenous infection
    G Ryan
    Department of Veterinary Pathology, Faculty of Veterinary Medicine, University College Dublin, Belfield, Dublin 4, Ireland
    J Virol 77:7477-85. 2003
    Animal models of human immunodeficiency virus 1, such as feline immunodeficiency virus (FIV), provide the opportunities to dissect the mechanisms of early interactions of the virus with the central nervous system (CNS)...
  92. ncbi Quantitative analysis of Fas and Fas ligand mRNAs in a feline T-lymphoid cell line after infection with feline immunodeficiency virus and primary peripheral blood mononuclear cells obtained from cats infected with the virus
    T Mizuno
    Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Vet Immunol Immunopathol 93:117-23. 2003
    Apoptosis is frequently observed in feline lymphocytes in association with feline immunodeficiency virus (FIV) infection...
  93. pmc Altered bone marrow dendritic cell cytokine production to toll-like receptor and CD40 ligation during chronic feline immunodeficiency virus infection
    Tracy L Lehman
    Departments of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, 80523, USA
    Immunology 126:405-12. 2009
    ..In this study, we examined the effect of chronic feline immunodeficiency virus (FIV) infection on DC cytokine production in response to microbial and T-cell stimulation...
  94. ncbi Feline immunodeficiency virus envelope glycoprotein mediates apoptosis in activated PBMC by a mechanism dependent on gp41 function
    Himanshu Garg
    Immunology Program, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA
    Virology 330:424-36. 2004
    b>Feline Immunodeficiency Virus (FIV) is a lentivirus that causes immunodeficiency in cats, which parallels HIV-1-induced immunodeficiency in humans...
  95. ncbi Pathogenesis of a Texas feline immunodeficiency virus isolate: an emerging subtype of clade B
    Anagha P Phadke
    Department of Biology, Texas A and M University, College Station, TX 77843 3258, United States
    Vet Microbiol 115:64-76. 2006
    We have recently provided evidence that Texas feline immunodeficiency virus (FIV-TX) isolates are an emerging subtype sharing a common ancestry with clade B isolates...
  96. pmc Early pathogenesis of transmucosal feline immunodeficiency virus infection
    Leslie A Obert
    Department of Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado 80523, USA
    J Virol 76:6311-22. 2002
    To identify the early target cells and tissues in transmucosal feline immunodeficiency virus (FIV) infection, cats were exposed to a clade C FIV isolate via the oral-nasal or vaginal mucosa and multiple tissues were examined by virus ..
  97. pmc Generation of infectious feline immunodeficiency virus (FIV) encoding FIV/human immunodeficiency virus chimeric protease
    Ying Chuan Lin
    Department of Immunology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Virol 84:6799-809. 2010
    b>Feline immunodeficiency virus (FIV) and human immunodeficiency virus type 1 (HIV-1) proteases (PRs) share only 23% amino acid identity and exhibit distinct specificities yet have very similar 3-dimensional structures...
  98. pmc Prevention of immunodeficiency virus induced CD4+ T-cell depletion by prior infection with a non-pathogenic virus
    Julie A Terwee
    Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado, USA
    Virology 377:63-70. 2008
    ..These data provide support for the importance of non-adaptive enhancement of the immune response in the prevention of CD4+ T-cell loss...
  99. pmc Ocelots on Barro Colorado Island are infected with feline immunodeficiency virus but not other common feline and canine viruses
    Samuel P Franklin
    Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, Colorado 80523, USA
    J Wildl Dis 44:760-5. 2008
    ..feline calicivirus, feline corona virus, feline panleukopenia virus, canine distemper virus, and feline immunodeficiency virus (FIV), typically a species-specific infection...
  100. ncbi Quality of different in-clinic test systems for feline immunodeficiency virus and feline leukaemia virus infection
    Katrin Hartmann
    Clinic for Small Animal Medicine, Ludwig Maximilian University Munich, Veterinaerstrasse 13, 80539 Munich, Germany
    J Feline Med Surg 9:439-45. 2007
    Many new diagnostic in-house tests for identification of feline immunodeficiency virus (FIV) and feline leukaemia virus (FeLV) infection have been licensed for use in veterinary practice, and the question of the relative merits of these ..
  101. ncbi Risk analysis of feline immunodeficiency virus infection in Tsushima leopard cats (Prionailurus bengalensis euptilurus) and domestic cats using a geographic information system
    Shin ichi Hayama
    Laboratory of Wildlife Medicine, Department of Veterinary Science, Nippon Veterinary and Life Science University, Musashino, Tokyo, Japan
    J Vet Med Sci 72:1113-8. 2010
    ..All FIV-positive leopard cats were found in the identified high FIV infection risk areas...

Research Grants88

  1. Stampidine: A Novel Broad-Spectrum Antiviral Agent
    Taracad Venkatachalam; Fiscal Year: 2003
    ..We are now proposing studies aimed at evaluating the safety and efficacy of STAMP against the feline immunodeficiency virus (FIV) infection in domestic cats, an established model for HIV-1 infection in man...
  2. INCIDENTAL INFECTIOUS DISEASES AS COFACTORS
    Niels Pedersen; Fiscal Year: 1990
    ..This aspect of HIV infection can be better studied using an appropriate animal model. Feline Immunodeficiency Virus (FIV) infection might provide such a model...
  3. PERIPHERAL NEUROPATHY IN LENTIVIRUS INFECTIONS: EARLY VIRAL AND HOST DETERMINANTS
    Christopher Power; Fiscal Year: 2010
    ..Lentiviruses including HIV-1 and feline immunodeficiency virus (FIV) cause immunosuppression and neurological disease defined by the development of DSP...
  4. SELF-ASSEMBLING ANTIRETROVIRAL AGENTS
    DARRYL RIDEOUT; Fiscal Year: 1993
    ..HPLC); (2) to synthesize new suramin-like hydrazones with anti-retroviral activity against HIV and feline immunodeficiency virus (FIV) by combining the LYCH-derived aldehydes and acylhydrazides that accumulate in monocytes; (3) to ..
  5. RRE LINKED MUCOSAL BARRIER TO LENTIVIRUS INFECTION
    Margaret Barr; Fiscal Year: 2000
    b>Feline immunodeficiency virus, a lentivirus of cats, provides a natural model for human immunodeficiency virus (HIV) infection and disease...
  6. RRE LINKED MUCOSAL BARRIER TO LENTIVIRUS INFECTION
    Margaret Barr; Fiscal Year: 1999
    b>Feline immunodeficiency virus, a lentivirus of cats, provides a natural model for human immunodeficiency virus (HIV) infection and disease...
  7. RRE LINKED MUCOSAL BARRIER TO LENTIVIRUS INFECTION
    Margaret Barr; Fiscal Year: 2000
    b>Feline immunodeficiency virus, a lentivirus of cats, provides a natural model for human immunodeficiency virus (HIV) infection and disease...
  8. RRE LINKED MUCOSAL BARRIER TO LENTIVIRUS INFECTION
    Margaret Barr; Fiscal Year: 1999
    b>Feline immunodeficiency virus, a lentivirus of cats, provides a natural model for human immunodeficiency virus (HIV) infection and disease...
  9. PERIPHERAL NEUROPATHY IN LENTIVIRUS INFECTIONS: EARLY VIRAL AND HOST DETERMINANTS
    Christopher Power; Fiscal Year: 2009
    ..Lentiviruses including HIV-1 and feline immunodeficiency virus (FIV) cause immunosuppression and neurological disease defined by the development of DSP...
  10. ENDOMEMBRANE TRAFFICKING OF FIV ENVELOPE GLYCOPROTEINS
    D Morre; Fiscal Year: 1990
    ..as a strategy for target identification in antiviral drug design using cultured cells infected with feline immunodeficiency virus (FIV)...
  11. MARROW SUPPRESSION FROM A LENTIVIRUS
    JANIS ABKOWITZ; Fiscal Year: 1993
    ..In addition, as FTLV does not infect human cells or cell lines, these studies involve less biohazard than cell culture studies with blood or marrow from AIDS patients...
  12. MARROW SUPPRESSION FROM A LENTIVIRUS
    JANIS ABKOWITZ; Fiscal Year: 1990
    ..In addition, as FTLV does not infect human cells or cell lines, these studies involve less biohazard than cell culture studies with blood or marrow from AIDS patients...
  13. Placental Treg Activation and Pregnancy Outcome in the FIV-infected Cat Model
    GREGORY TODD PHARR; Fiscal Year: 2010
    ..The purpose of this project is to evaluate the effect of HIV infection on the function of regulatory T cells, using the feline immunodeficiency virus (FIV)-infected cat to model maternal-fetal infection and compromised pregnancy.
  14. Placental Treg Activation and Pregnancy Outcome in the FIV-infected Cat Model
    KAREN COATS; Fiscal Year: 2009
    ..The purpose of this project is to evaluate the effect of HIV infection on the function of regulatory T cells, using the feline immunodeficiency virus (FIV)-infected cat to model maternal-fetal infection and compromised pregnancy.
  15. Hemophilia A: Intrathymic Delivery for Tolerance and Longterm Expression of FVIII
    William Raschke; Fiscal Year: 2007
    ..With respect to the delivery system, a non-primate lentiviral vector derived from Feline Immunodeficiency Virus (FIV) provides excellent transduction efficiency of a variety of cells and organs including stromal ..
  16. Stampidine: A Novel Broad-Spectrum Anti-HIV Microbicide
    OSMOND D CRUZ; Fiscal Year: 2005
    ..of STAMP >4-logs higher than its IC50 value and exhibited potent antiretroviral activity in feline immunodeficiency virus (FlV)-infected cats...
  17. AIDS DEMENTIA: MOLECULAR AND CELLULAR MECHANISMS
    Floyd Bloom; Fiscal Year: 1990
    ..model systems suitable for invasive experimental investigation: Simian Immunodeficiency Virus (SIV), Feline Immunodeficiency Virus (FIV) and persistent selected neuronal infection with a murine neurotropic arenavirus, lymphocytic ..
  18. RECOMBINANT LISTERIA--BIOLOGIC VACCINE VECTOR FOR FIV
    Gregg Dean; Fiscal Year: 2000
    ..These studies will be performed using the feline immunodeficiency virus (FIV) infection of cats as a model for HIV infection of people...
  19. RECOMBINANT LISTERIA--BIOLOGIC VACCINE VECTOR FOR FIV
    Gregg Dean; Fiscal Year: 2001
    ..These studies will be performed using the feline immunodeficiency virus (FIV) infection of cats as a model for HIV infection of people...
  20. PATHOGENESIS OF FELINE IMMUNODEFICIENCY VIRUS--AIDS
    Wayne Tompkins; Fiscal Year: 1991
    ..The investigators have demonstrated that cats naturally or experimentally infected with Feline Immunodeficiency Virus (FIV) also show an inverted CD4+:CD8+ ratio due to decreased numbers of CD4+ cells...
  21. AIDS DEMENTIA--MOLECULAR AND CELLULAR MECHANISMS
    Floyd Bloom; Fiscal Year: 1999
    ..and immunological manifestations of infection with Simian Immunodeficiency Virus (SIV), and Feline Immunodeficiency Virus (FIV) as well as transgenic mice over- expressing either the cytokines mediating inflammatory and ..
  22. Quantifying cognitive-motor decline in FIV-infected cats
    Lola C Hudson; Fiscal Year: 2010
    ..b>Feline immunodeficiency virus (FIV) offers an alternative model of lentiviral neuropathogenesis which recapitulates all essential ..
  23. AIDS DEMENTIA--MOLECULAR AND CELLULAR MECHANISMS
    Floyd Bloom; Fiscal Year: 1999
    ..and immunological manifestations of infection with Simian Immunodeficiency Virus (SIV), and Feline Immunodeficiency Virus (FIV) as well as transgenic mice over- expressing either the cytokines mediating inflammatory and ..
  24. Molecular Analysis of FIV
    John Elder; Fiscal Year: 2007
    ..provided by applicant): The proposed research is for continuation of studies to characterize the feline immunodeficiency virus (FIV) genome, to define mechanisms of entry into target cells and details of the virus life cycle...
  25. Evaluation of thymus function in lentivirus disease
    Lawrence Mathes; Fiscal Year: 2006
    ..b>Feline immunodeficiency virus (FIV) infection of cats leads to significant pathological changes in the thymus with many similar ..
  26. Evaluation of thymus function in lentivirus disease
    Lawrence Mathes; Fiscal Year: 2007
    ..b>Feline immunodeficiency virus (FIV) infection of cats leads to significant pathological changes in the thymus with many similar ..
  27. Evaluation of thymus function in lentivirus disease
    Lawrence Mathes; Fiscal Year: 2009
    ..b>Feline immunodeficiency virus (FIV) infection of cats leads to significant pathological changes in the thymus with many similar ..
  28. Evaluation of thymus function in lentivirus disease
    Lawrence Mathes; Fiscal Year: 2005
    ..b>Feline immunodeficiency virus (FIV) infection of cats leads to significant pathological changes in the thymus with many similar ..
  29. Vanadocenes as a New Class of Spermicidal Drugs
    OSMOND D CRUZ; Fiscal Year: 2007
    ..VDDTC significantly enhanced the microbicide efficacy of the antiretroviral spermicide WHI- 07 in the feline immunodeficiency virus/cat model of AIDS...
  30. Vanadocenes as a New Class of Spermicidal Drugs
    OSMOND D CRUZ; Fiscal Year: 2006
    ..VDDTC significantly enhanced the microbicide efficacy of the antiretroviral spermicide WHI- 07 in the feline immunodeficiency virus/cat model of AIDS...
  31. Choroid plexus macrophages in FIV neuropathogenesis
    RICK MEEKER; Fiscal Year: 2006
    ..b>Feline immunodeficiency virus (FIV) offers an alternative model of lentiviral neuropathogenesis which recapitulates all essential ..
  32. Choroid plexus macrophages in FIV neuropathogenesis
    RICK MEEKER; Fiscal Year: 2009
    ..b>Feline immunodeficiency virus (FIV) offers an alternative model of lentiviral neuropathogenesis which recapitulates all essential ..
  33. Choroid plexus macrophages in FIV neuropathogenesis
    RICK MEEKER; Fiscal Year: 2007
    ..b>Feline immunodeficiency virus (FIV) offers an alternative model of lentiviral neuropathogenesis which recapitulates all essential ..
  34. Lentiviral Genome Processing
    Eric Poeschla; Fiscal Year: 2005
    ..The laboratory studies HIV-1 and feline immunodeficiency virus (FIV)...
  35. Lentiviral Genome Processing
    Eric Poeschla; Fiscal Year: 2006
    ..The laboratory studies HIV-1 and feline immunodeficiency virus (FIV)...
  36. Lentiviral Genome Processing
    Eric Poeschla; Fiscal Year: 2003
    ..The laboratory studies HIV-1 and feline immunodeficiency virus (FIV)...
  37. Lentiviral Genome Processing
    Eric Poeschla; Fiscal Year: 2007
    ..The laboratory studies HIV-1 and feline immunodeficiency virus (FIV)...
  38. Mechanisms of Feline Lentivirus Control and Interference
    Sue Vandewoude; Fiscal Year: 2010
    ..avirulent infection, and have determined that such infection attenuates subsequent virulent feline immunodeficiency virus (FIV) challenge...
  39. Mechanisms of Feline Lentivirus Control and Interference
    Sue Vandewoude; Fiscal Year: 2009
    ..avirulent infection, and have determined that such infection attenuates subsequent virulent feline immunodeficiency virus (FIV) challenge...
  40. Mechanisms of Feline Lentivirus Control and Interference
    Sue Vandewoude; Fiscal Year: 2007
    ..avirulent infection, and have determined that such infection attenuates subsequent virulent feline immunodeficiency virus (FIV) challenge...
  41. Mechanisms of Feline Lentivirus Control and Interference
    Sue Vandewoude; Fiscal Year: 2009
    ..avirulent infection, and have determined that such infection attenuates subsequent virulent feline immunodeficiency virus (FIV) challenge...
  42. Characterization of cell clones resistant to HIV
    Richard Sutton; Fiscal Year: 2007
    ..leucosis virus, human foamy virus, bovine immunodeficiency virus, equine infectious anemia virus, feline immunodeficiency virus, and SIV...
  43. Characterization of cell clones resistant to HIV
    Richard Sutton; Fiscal Year: 2006
    ..leucosis virus, human foamy virus, bovine immunodeficiency virus, equine infectious anemia virus, feline immunodeficiency virus, and SIV...
  44. Feline Immunodeficiency Virus Orf-A a Model for HIV Vpr
    Ellen Sparger; Fiscal Year: 2007
    The feline immunodeficiency virus (FIV) animal model presents a unique and significant opportunity for assessing novel antiviral strategies for HIV/AIDS in humans...
  45. Feline Immunodeficiency Virus Orf-A a Model for HIV Vpr
    Ellen Sparger; Fiscal Year: 2005
    The feline immunodeficiency virus (FIV) animal model presents a unique and significant opportunity for assessing novel antiviral strategies for HIV/AIDS in humans...
  46. Feline Immunodeficiency Virus Orf-A a Model for HIV Vpr
    Ellen Sparger; Fiscal Year: 2004
    The feline immunodeficiency virus (FIV) animal model presents a unique and significant opportunity for assessing novel antiviral strategies for HIV/AIDS in humans...
  47. Feline Immunodeficiency Virus Orf-A a Model for HIV Vpr
    Ellen Sparger; Fiscal Year: 2006
    The feline immunodeficiency virus (FIV) animal model presents a unique and significant opportunity for assessing novel antiviral strategies for HIV/AIDS in humans...
  48. SIV delta vif DNA Vaccines with Cytokine Adjuvants
    Ellen Sparger; Fiscal Year: 2004
    ..We have been investigating live-attenuated feline immunodeficiency virus (FIV) vaccines for inducing protective immunity in cats (Preliminary Results)...
  49. AIDS DEMENTIA--MOLECULAR AND CELLULAR MECHANISMS
    Floyd Bloom; Fiscal Year: 2000
    ..and immunological manifestations of infection with Simian Immunodeficiency Virus (SIV), and Feline Immunodeficiency Virus (FIV) as well as transgenic mice over- expressing either the cytokines mediating inflammatory and ..
  50. Quantifying cognitive-motor decline in FIV-infected cats
    LOLA HUDSON; Fiscal Year: 2009
    ..b>Feline immunodeficiency virus (FIV) offers an alternative model of lentiviral neuropathogenesis which recapitulates all essential ..
  51. FIV-MD AS A MODEL FOR AGE-DEPENDENT NEURO-AIDS
    Michael Podell; Fiscal Year: 1999
    ..neuropathogenesis of lentiviral infection of the brain using the neurotropic Maryland isolate of the feline immunodeficiency virus (FIV-MD) as a model in experimentally infected cats...
  52. Microglia and choroid plexus macrophages in Neuro-AIDS
    RICK MEEKER; Fiscal Year: 2002
    ..Using feline immunodeficiency virus (FIV) we have developed a model of viral infection and pathogenesis that may help to explain how each ..
  53. CELL ASSOCIATED FIV--VAGINAL TRANSMISSION AND PROTECTION
    MARY BURKHARD; Fiscal Year: 2002
    ..While cell-associated SIV is not efficiently transferred (if at all) across the vaginal mucosa, feline immunodeficiency virus (FIV) mimics the cell-associated versus cell-free diversity apparent in HIV vaginal transmission...
  54. CELL ASSOCIATED FIV--VAGINAL TRANSMISSION AND PROTECTION
    MARY BURKHARD; Fiscal Year: 2001
    ..While cell-associated SIV is not efficiently transferred (if at all) across the vaginal mucosa, feline immunodeficiency virus (FIV) mimics the cell-associated versus cell-free diversity apparent in HIV vaginal transmission...
  55. CELL ASSOCIATED FIV--VAGINAL TRANSMISSION AND PROTECTION
    MARY BURKHARD; Fiscal Year: 1999
    ..While cell-associated SIV is not efficiently transferred (if at all) across the vaginal mucosa, feline immunodeficiency virus (FIV) mimics the cell-associated versus cell-free diversity apparent in HIV vaginal transmission...
  56. CELL ASSOCIATED FIV--VAGINAL TRANSMISSION AND PROTECTION
    MARY BURKHARD; Fiscal Year: 2003
    ..While cell-associated SIV is not efficiently transferred (if at all) across the vaginal mucosa, feline immunodeficiency virus (FIV) mimics the cell-associated versus cell-free diversity apparent in HIV vaginal transmission...
  57. CELL ASSOCIATED FIV--VAGINAL TRANSMISSION AND PROTECTION
    MARY BURKHARD; Fiscal Year: 2000
    ..While cell-associated SIV is not efficiently transferred (if at all) across the vaginal mucosa, feline immunodeficiency virus (FIV) mimics the cell-associated versus cell-free diversity apparent in HIV vaginal transmission...
  58. FELINE IMMUNODEFICIENCY VIRUS GENE EXPRESSION
    Paul Luciw; Fiscal Year: 1990
    b>Feline immunodeficiency virus (FIV) is a lymphocytopathic lentivirus associated with fatal immunodeficiency in cats...
  59. Receptor usage and pathogenicity of feline lentiviruses
    BRIAN WILLETT; Fiscal Year: 2001
    ..build upon our earlier work demonstrating that CXCR-4 is the major, if not sole, co-receptor for the feline immunodeficiency virus (FIV) lentivirus of the domestic cat...
  60. Enhancing hepatocyte gene transfer for Hemophilia A
    Paul McCray; Fiscal Year: 2006
    ..Towards this end, we are using a lentiviral vector based on the non-primate feline immunodeficiency virus (FIV) expressing the human FVIII (FVIII) cDNA to correct the phenotype in a mouse model of the ..
  61. FELINE IMMUNODEFICIENCY VIRUS LTR MUTANTS INFECTION
    Ellen Sparger; Fiscal Year: 1993
    ....
  62. Enhancing hepatocyte gene transfer for Hemophilia A
    Paul McCray; Fiscal Year: 2005
    ..Towards this end, we are using a lentiviral vector based on the non-primate feline immunodeficiency virus (FIV) expressing the human FVIII (FVIII) cDNA to correct the phenotype in a mouse model of the ..
  63. Enhancing hepatocyte gene transfer for Hemophilia A
    Paul McCray; Fiscal Year: 2007
    ..Towards this end, we are using a lentiviral vector based on the non-primate feline immunodeficiency virus (FIV) expressing the human FVIII (FVIII) cDNA to correct the phenotype in a mouse model of the ..
  64. Lentiviral gene tranfer to porcine airway epithelia
    Paul B McCray; Fiscal Year: 2011
    ..Towards this goal, our Project has developed lentiviral vectors based on feline immunodeficiency virus (FIV) because of their ability to integrate and persist...
  65. Functional Analysis of FIV ORF-A
    Ayalew Mergia; Fiscal Year: 2002
    DESCRIPTION (provided by applicant):Feline immunodeficiency virus (FIV), a lentivirus of cats, causes an AIDS similar to what is seen in humans with human immunodeficiency virus (HIV)...
  66. Functional Analysis of FIV ORF-A
    Ayalew Mergia; Fiscal Year: 2003
    DESCRIPTION (provided by applicant):Feline immunodeficiency virus (FIV), a lentivirus of cats, causes an AIDS similar to what is seen in humans with human immunodeficiency virus (HIV)...
  67. Functional Analysis of FIV ORF-A
    Ayalew Mergia; Fiscal Year: 2004
    DESCRIPTION (provided by applicant):Feline immunodeficiency virus (FIV), a lentivirus of cats, causes an AIDS similar to what is seen in humans with human immunodeficiency virus (HIV)...
  68. Targeting Entry in Epithelia with ICMV-FIV
    Paul McCray; Fiscal Year: 2004
    ..this program focused on the development and application of recombinant lentiviral vectors based on feline immunodeficiency virus (FIV) to surmount these problems...
  69. SIV delta vif DNA Vaccines with Cytokine Adjuvants
    Ellen Sparger; Fiscal Year: 2003
    ..We have been investigating live-attenuated feline immunodeficiency virus (FIV) vaccines for inducing protective immunity in cats (Preliminary Results)...
  70. PROPHYLAXIS OF FETAL HEMATOPOIETIC CELLS FOR FIV
    Ayalew Mergia; Fiscal Year: 2000
    ..The animal model system we will employ is the feline immunodeficiency virus (FIV) in cats...
  71. PROPHYLAXIS OF FETAL HEMATOPOIETIC CELLS FOR FIV
    Ayalew Mergia; Fiscal Year: 2001
    ..The animal model system we will employ is the feline immunodeficiency virus (FIV) in cats...