feline immunodeficiency virus

Summary

Summary: A species of LENTIVIRUS, subgenus feline lentiviruses (LENTIVIRUSES, FELINE) isolated from cats with a chronic wasting syndrome, presumed to be immune deficiency. There are 3 strains: Petaluma (FIP-P), Oma (FIP-O) and Puma lentivirus (PLV). There is no antigenic relationship between FIV and HIV, nor does FIV grow in human T-cells.

Top Publications

  1. pmc Pathological manifestations of feline immunodeficiency virus (FIV) infection in wild African lions
    Melody E Roelke
    Laboratory of Genomic Diversity, SAIC Frederick, Inc, NCI Frederick, Frederick, MD, USA
    Virology 390:1-12. 2009
  2. pmc Feline immunodeficiency virus (FIV) as a model for study of lentivirus infections: parallels with HIV
    John H Elder
    Department of Immunology and Microbial Sciences, The Scripps Research Institute, La Jolla, CA 92037, USA
    Curr HIV Res 8:73-80. 2010
  3. ncbi Combined effect of zidovudine (ZDV), lamivudine (3TC) and abacavir (ABC) antiretroviral therapy in suppressing in vitro FIV replication
    Leslie R Bisset
    Swiss National Center for Retroviruses, University of Zurich, Gloriastrasse 30, CH 8028, Zurich, Switzerland
    Antiviral Res 53:35-45. 2002
  4. pmc In vivo antiretroviral activity of stampidine in chronically feline immunodeficiency virus-infected cats
    Fatih M Uckun
    Drug Discovery Program, Parker Hughes Cancer Center, St Paul, Minnesota, USA
    Antimicrob Agents Chemother 47:1233-40. 2003
  5. ncbi Toward a detailed characterization of feline immunodeficiency virus-specific T cell immune responses and mediated immune disorders
    R Paillot
    Discovery Research, MERIAL S A S, 254 rue Marcel Mérieux BP 7009, 69342 Lyon Cedex 07, France
    Vet Immunol Immunopathol 106:1-14. 2005
  6. pmc OrfA downregulates feline immunodeficiency virus primary receptor CD134 on the host cell surface and is important in viral infection
    Yang Hong
    Department of Immunology and Microbial Science, The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, CA 92037, USA
    J Virol 84:7225-32. 2010
  7. ncbi Functional interactions of nucleocapsid protein of feline immunodeficiency virus and cellular prion protein with the viral RNA
    Mila Moscardini
    Department of Biomedicine, University of Pisa, I 56127 Pisa, Italy
    J Mol Biol 318:149-59. 2002
  8. ncbi Mucosal administration of low-dose cell-associated feline immunodeficiency virus promotes viral latency
    Barnabe Dossou Assogba
    Department of Veterinary Biosciences, The Ohio State University, Columbus, OH 43210, USA
    J Infect Dis 195:1184-8. 2007
  9. pmc Shared usage of the chemokine receptor CXCR4 by the feline and human immunodeficiency viruses
    B J Willett
    Department of Veterinary Pathology, University of Glasgow Veterinary School, United Kingdom
    J Virol 71:6407-15. 1997
  10. pmc Mapping the encapsidation determinants of feline immunodeficiency virus
    Iris Kemler
    Molecular Medicine Program, Departments of Immunology and Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Virol 76:11889-903. 2002

Detail Information

Publications304 found, 100 shown here

  1. pmc Pathological manifestations of feline immunodeficiency virus (FIV) infection in wild African lions
    Melody E Roelke
    Laboratory of Genomic Diversity, SAIC Frederick, Inc, NCI Frederick, Frederick, MD, USA
    Virology 390:1-12. 2009
    b>Feline immunodeficiency virus (FIV) causes AIDS in the domestic cat (Felis catus) but has not been explicitly associated with AIDS pathology in any of the eight free-ranging species of Felidae that are endemic with circulating FIV ..
  2. pmc Feline immunodeficiency virus (FIV) as a model for study of lentivirus infections: parallels with HIV
    John H Elder
    Department of Immunology and Microbial Sciences, The Scripps Research Institute, La Jolla, CA 92037, USA
    Curr HIV Res 8:73-80. 2010
    ..The following review highlights both the strengths and shortcomings of the FIV/cat model, particular as regards development of antiviral drugs...
  3. ncbi Combined effect of zidovudine (ZDV), lamivudine (3TC) and abacavir (ABC) antiretroviral therapy in suppressing in vitro FIV replication
    Leslie R Bisset
    Swiss National Center for Retroviruses, University of Zurich, Gloriastrasse 30, CH 8028, Zurich, Switzerland
    Antiviral Res 53:35-45. 2002
    In view of close similarities at the molecular and clinical levels, feline immunodeficiency virus (FIV) infection of the domestic cat is subject of increasing attention as an animal model for human immunodeficiency virus (HIV) infection...
  4. pmc In vivo antiretroviral activity of stampidine in chronically feline immunodeficiency virus-infected cats
    Fatih M Uckun
    Drug Discovery Program, Parker Hughes Cancer Center, St Paul, Minnesota, USA
    Antimicrob Agents Chemother 47:1233-40. 2003
    ..reverse transcriptase inhibitor (NRTI) compound stampidine in cats chronically infected with feline immunodeficiency virus (FIV)...
  5. ncbi Toward a detailed characterization of feline immunodeficiency virus-specific T cell immune responses and mediated immune disorders
    R Paillot
    Discovery Research, MERIAL S A S, 254 rue Marcel Mérieux BP 7009, 69342 Lyon Cedex 07, France
    Vet Immunol Immunopathol 106:1-14. 2005
    Infection of domestic cats with feline immunodeficiency virus (FIV) is associated with the development of an acquired immunodeficiency syndrome (AIDS)...
  6. pmc OrfA downregulates feline immunodeficiency virus primary receptor CD134 on the host cell surface and is important in viral infection
    Yang Hong
    Department of Immunology and Microbial Science, The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, CA 92037, USA
    J Virol 84:7225-32. 2010
    b>Feline immunodeficiency virus (FIV) OrfA is an accessory protein that is critical for productive viral replication and infection in T cells...
  7. ncbi Functional interactions of nucleocapsid protein of feline immunodeficiency virus and cellular prion protein with the viral RNA
    Mila Moscardini
    Department of Biomedicine, University of Pisa, I 56127 Pisa, Italy
    J Mol Biol 318:149-59. 2002
    ..properties of the human prion protein, we set up an in vitro system to investigate replication of the feline immunodeficiency virus (FIV), which is functionally and phylogenetically distant from HIV-1...
  8. ncbi Mucosal administration of low-dose cell-associated feline immunodeficiency virus promotes viral latency
    Barnabe Dossou Assogba
    Department of Veterinary Biosciences, The Ohio State University, Columbus, OH 43210, USA
    J Infect Dis 195:1184-8. 2007
    ..To develop an animal model of host latency, cats were mucosally challenged with 10(2)-10(6) feline immunodeficiency virus (FIV)-infected T cells...
  9. pmc Shared usage of the chemokine receptor CXCR4 by the feline and human immunodeficiency viruses
    B J Willett
    Department of Veterinary Pathology, University of Glasgow Veterinary School, United Kingdom
    J Virol 71:6407-15. 1997
    b>Feline immunodeficiency virus (FIV) induces a disease state in the domestic cat that is similar to AIDS in human immunodeficiency virus (HIV)-infected individuals...
  10. pmc Mapping the encapsidation determinants of feline immunodeficiency virus
    Iris Kemler
    Molecular Medicine Program, Departments of Immunology and Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Virol 76:11889-903. 2002
    ..Feline lentiviral (feline immunodeficiency virus [FIV]) encapsidation has not been studied...
  11. ncbi Delineation of sequences important for efficient packaging of feline immunodeficiency virus RNA
    Matthew T Browning
    The University of Texas MD Anderson Cancer Center, Department of Veterinary Sciences, Bastrop, TX 78602, USA
    J Gen Virol 84:621-7. 2003
    We have used systematic deletion analysis of the 5' untranslated region (UTR) of the feline immunodeficiency virus (FIV) genome, both in the presence and absence of various amounts of gag, to define the cis-acting sequences responsible ..
  12. ncbi Structural mapping of CD134 residues critical for interaction with feline immunodeficiency virus
    Aymeric de Parseval
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Nat Struct Mol Biol 12:60-6. 2005
    CD134 is a primary binding receptor for feline immunodeficiency virus (FIV), and with CXCR4 facilitates infection of CD4(+) T cells. Human CD134 fails to support FIV infection...
  13. pmc Going wild: lessons from naturally occurring T-lymphotropic lentiviruses
    Sue Vandewoude
    Department of Microbiology, Immunology and Pathology, College of Veterinary and Biomedical Sciences, Colorado State University, Fort Collins, CO 80538 1619, USA
    Clin Microbiol Rev 19:728-62. 2006
    ..more than 20 species of nondomestic felids and African hyenids demonstrate seroreactivity against feline immunodeficiency virus (FIV) antigens...
  14. pmc Molecular epidemiology of feline immunodeficiency virus in the domestic cat (Felis catus)
    Jessica J Hayward
    Bioinformatics Institute, Allan Wilson Centre for Molecular Ecology and Evolution, School of Biological Sciences, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand
    Vet Immunol Immunopathol 134:68-74. 2010
    Studying the evolutionary mechanisms of feline immunodeficiency virus in the domestic cat (Felis catus), FIV(Fca), provides a good comparison to other lentiviruses, such as HIV and FIV(Pco) in the cougar (Puma concolor)...
  15. ncbi Prevalence of feline immunodeficiency virus and feline leukaemia virus among client-owned cats and risk factors for infection in Germany
    Sabine E Gleich
    Clinic of Small Animal Internal Medicine, Ludwig Maximilian University Munich, Veterinarstrasse 13, 80539 Munich, Germany
    J Feline Med Surg 11:985-92. 2009
    ..population in Germany by evaluation of 17,462 client-owned cats that were tested for the presence of feline immunodeficiency virus (FIV) antibodies or feline leukaemia virus (FeLV) antigen...
  16. ncbi Seroprevalences of feline leukemia virus and feline immunodeficiency virus in cats with abscesses or bite wounds and rate of veterinarian compliance with current guidelines for retrovirus testing
    Carrie E Goldkamp
    Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 32610, USA
    J Am Vet Med Assoc 232:1152-8. 2008
    ....
  17. pmc Preferential feline immunodeficiency virus (FIV) infection of CD4+ CD25+ T-regulatory cells correlates both with surface expression of CXCR4 and activation of FIV long terminal repeat binding cellular transcriptional factors
    Anjali Joshi
    Immunology Program, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina 27606, USA
    J Virol 79:4965-76. 2005
    ..T-regulatory (Treg) cells with regard to their immune regulatory properties and ability to support feline immunodeficiency virus (FIV) replication in vitro and in vivo...
  18. pmc Vif of feline immunodeficiency virus from domestic cats protects against APOBEC3 restriction factors from many felids
    Jörg Zielonka
    Clinic for Gastroenterology, Hepatology and Infectiology, Heinrich Heine University, Building 23 12 U1 87, Moorenstr 5, 40225 Dusseldorf, Germany
    J Virol 84:7312-24. 2010
    ..more insight into the role of APOBEC3 (A3) cytidine deaminases in the species-specific restriction of feline immunodeficiency virus (FIV) of the domestic cat, we tested the A3 proteins present in big cats (puma, lion, tiger, and lynx)...
  19. ncbi Feline leukaemia virus (FeLV) and feline immunodeficiency virus infections in cats in the Pisa district of Tuscany, and attempts to control FeLV infection in a colony of domestic cats by vaccination
    P Bandecchi
    Dipartimento di Patologia Animale, Profilassi ed Igiene degli Alimenti, Universita di Pisa, Viale delle Piagge 2, 56100 Pisa, Italy
    Vet Rec 158:555-7. 2006
    The seroprevalence of feline immunodeficiency virus (FIV) in 203 apparently healthy domestic cats living in the district of Pisa, central Italy, was 11.3 per cent, and the prevalence of feline leukaemia virus (FeLV) was 8.4 per cent...
  20. pmc Seroprevalence of feline leukemia virus and feline immunodeficiency virus infection among cats in Canada
    Susan Little
    Bytown Cat Hospital, 422 McArthur Ave, Ottawa, Ontario K1K 1G6, Canada
    Can Vet J 50:644-8. 2009
    The purposes of this study were to determine the seroprevalence of feline leukemia virus (FeLV) and feline immunodeficiency virus (FIV) infection among cats in Canada and to identify risk factors for seropositivity...
  21. pmc Feline immunodeficiency virus neuropathogenesis: from cats to calcium
    Rick B Meeker
    Department of Neurology, University of North Carolina, CB 7025, 6109F Neuroscience Research Bldg, Chapel Hill, NC 27599, USA
    J Neuroimmune Pharmacol 2:154-70. 2007
    ..made from in vitro and in vivo studies on the infectious and pathological interactions of feline immunodeficiency virus (FIV) with the nervous system...
  22. ncbi Feline immunodeficiency virus infection phenotypically and functionally activates immunosuppressive CD4+CD25+ T regulatory cells
    Thomas W Vahlenkamp
    Immunology Program, North Carolina State University, Raleigh, NC 27606, USA
    J Immunol 172:4752-61. 2004
    Disease progression of feline immunodeficiency virus (FIV) infection is characterized by up-regulation of B7.1 and B7.2 costimulatory molecules and their ligand CTLA4 on CD4(+) and CD8(+) T cells...
  23. pmc Cytokine response in multiple lymphoid tissues during the primary phase of feline immunodeficiency virus infection
    G A Dean
    Department of Microbiology, Pathology, and Parasitology, North Carolina State University, Raleigh, North Carolina 27606, USA
    J Virol 72:9436-40. 1998
    ..various time periods and in various lymphoid compartments during the acute stage (first 4 months) of feline immunodeficiency virus (FIV) infection in laboratory cats. Cytokine responses were correlated with virus replication...
  24. pmc Neonatal gene therapy of glycogen storage disease type Ia using a feline immunodeficiency virus-based vector
    Albert Grinshpun
    Goldyne Savad Institute of Gene Therapy, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Mol Ther 18:1592-8. 2010
    ..Vectors have been constructed from feline immunodeficiency virus (FIV), a nonprimate lentivirus, because the wild-type virus does not cause disease in humans...
  25. pmc Human gene therapy vectors derived from feline lentiviruses
    Román A Barraza
    Molecular Medicine Program, Guggenheim 18, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, United States
    Vet Immunol Immunopathol 123:23-31. 2008
    Lentiviral vectors are useful for gene transfer to dividing and nondividing cells. Feline immunodeficiency virus (FIV) vectors transduce most human cell types with good efficiency and may have advantages for clinical gene therapy ..
  26. ncbi Antiviral activity of membrane fusion inhibitors that target gp40 of the feline immunodeficiency virus envelope protein
    Fuminori Mizukoshi
    Department of Veterinary Internal Medicine, The University of Tokyo, Bunkyo ku, Tokyo 113 8657, Japan
    Vet Microbiol 136:155-9. 2009
    ..to examine the inhibitory effect of modified peptides corresponding to heptad repeats (HR) 1 and 2 of feline immunodeficiency virus (FIV) envelope gp40 on the fusion between the viral and cellular membranes...
  27. pmc Immunohistochemical localization of feline immunodeficiency virus using native species antibodies
    Arlin B Rogers
    Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, Colorado 80523 1674, USA
    Am J Pathol 161:1143-51. 2002
    b>Feline immunodeficiency virus (FIV) is the feline analog of human immunodeficiency virus and a small animal model of human acquired immune deficiency syndrome (AIDS)...
  28. pmc RNA secondary structure of the feline immunodeficiency virus 5'UTR and Gag coding region
    Laurie James
    CNRS UPR2167 Centre de Génétique Moléculaire, Avenue de la Terrasse, 91190 Gif sur Yvette, France
    Nucleic Acids Res 36:4653-66. 2008
    ..into the structure-function relationship of lentiviral 5'UTRs, we modelled the RNA structure of the feline immunodeficiency virus (FIV), a virus that is evolutionarily distant from the primate viruses...
  29. pmc Genetically divergent strains of feline immunodeficiency virus from the domestic cat (Felis catus) and the African lion (Panthera leo) share usage of CD134 and CXCR4 as entry receptors
    William A McEwan
    Faculty of Veterinary Medicine, Retrovirus Research Laboratory, Institute of Comparative Medicine, University of Glasgow, Bearsden Road, Glasgow, United Kingdom
    J Virol 82:10953-8. 2008
    The env open reading frames of African lion (Panthera leo) lentivirus (feline immunodeficiency virus [FIV(Ple)]) subtypes B and E from geographically distinct regions of Africa suggest two distinct ancestries, with FIV(Ple)-E sharing a ..
  30. ncbi Seroprevalence of feline leukemia virus and feline immunodeficiency virus infection among cats in North America and risk factors for seropositivity
    Julie K Levy
    Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 32610 0126, USA
    J Am Vet Med Assoc 228:371-6. 2006
    ..To determine seroprevalence of FeLV and FIV infection among cats in North America and risk factors for seropositivity...
  31. pmc Modulation of the virus-receptor interaction by mutations in the V5 loop of feline immunodeficiency virus (FIV) following in vivo escape from neutralising antibody
    Brian J Willett
    Retrovirus Research Laboratory, Institute of Comparative Medicine, Faculty of Veterinary Medicine, University of Glasgow, Bearsden Road, Glasgow, UK
    Retrovirology 7:38. 2010
    In the acute phase of infection with feline immunodeficiency virus (FIV), the virus targets activated CD4+ T cells by utilising CD134 (OX40) as a primary attachment receptor and CXCR4 as a co-receptor...
  32. ncbi Pre-existing immunity to pathogenic Listeria monocytogenes does not prevent induction of immune responses to feline immunodeficiency virus by a novel recombinant Listeria monocytogenes vaccine
    Rosemary Stevens
    Department of Microbiology, Pathology and Parasitology, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
    Vaccine 23:1479-90. 2005
    ..The FIV/cat model will provide a useful challenge system to determine whether recombinant L. monocytogenes can protect against a lentivirus in its natural host after challenge by the routes common to HIV transmission...
  33. ncbi Mutational analysis of the feline immunodeficiency virus matrix protein
    M L Manrique
    , Serrano 669, C1414DEM, Buenos Aires, Argentina
    Virus Res 76:103-13. 2001
    To study the process of feline immunodeficiency virus (FIV) assembly, we examined the suitability of the vaccinia vector system to reproduce FIV particle formation...
  34. ncbi Molecular subtyping of feline immunodeficiency virus from domestic cats in Australia
    R K C Kann
    School of Veterinary Science, University of Queensland, Queensland
    Aust Vet J 84:112-6. 2006
    To determine the prevalent subtypes of feline immunodeficiency virus (FIV) present in the domestic cat population of Australia.
  35. ncbi Phylogenetic analysis to define feline immunodeficiency virus subtypes in 31 domestic cats in South Africa
    R Kann
    School of Veterinary Science, University of Queensland, St Lucia, Queensland, 4072, Australia
    J S Afr Vet Assoc 77:108-13. 2006
    b>Feline immunodeficiency virus (FIV), a lentivirus, is an important pathogen of domestic cats around the world and has many similarities to human immunodeficiency virus (HIV)...
  36. ncbi A feline immunodeficiency virus vif-deletion mutant remains attenuated upon infection of newborn kittens
    Xiaoying Shen
    Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    J Gen Virol 88:2793-9. 2007
    ..attenuation associated with a vif mutation by inoculation of newborn kittens with a vif-deleted feline immunodeficiency virus provirus plasmid (FIV-pPPRDeltavif)...
  37. ncbi Phylogenetic analysis of Vietnamese isolates of feline immunodeficiency virus: genetic diversity of subtype C
    K Nakamura
    Department of Veterinary Microbiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan
    Arch Virol 148:783-91. 2003
    Phylogenetic relationships of novel Vietnamese strains of feline immunodeficiency virus (FIV) were analysed...
  38. ncbi High genetic stability of TM1 and TM2 strains of subtype B feline immunodeficiency virus in long-term infection
    Yasuhiro Ikeda
    Department of Veterinary Microbiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Japan
    J Vet Med Sci 66:287-9. 2004
    To know the genetic changes of feline immunodeficiency virus (FIV) in long-term infection in cats, we inoculated three specific pathogen-free cats with FIV isolates and determined a partial env sequence covering the V3-V5 region...
  39. pmc Feline immunodeficiency virus (FIV) in wild Pallas' cats
    Meredith A Brown
    Laboratory of Genomic Diversity, National Cancer Institute Frederick, Frederick, MD 21702, USA
    Vet Immunol Immunopathol 134:90-5. 2010
    b>Feline immunodeficiency virus (FIV), a feline lentivirus related to HIV, causes immune dysfunction in domestic and wild cats...
  40. ncbi Intrahost evolution of envelope glycoprotein and OrfA sequences after experimental infection of cats with a molecular clone and a biological isolate of feline immunodeficiency virus
    Willem Huisman
    Erasmus MC, Institute of Virology, Rotterdam, The Netherlands
    Virus Res 137:24-32. 2008
    b>Feline immunodeficiency virus (FIV) is a member of the genus Lentivirus and causes AIDS-like disease in its natural host, the cat...
  41. ncbi Use of CD134 as a primary receptor by the feline immunodeficiency virus
    Masayuki Shimojima
    Department of Veterinary Microbiology, Graduate School of Agricultural and Life Sciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Science 303:1192-5. 2004
    b>Feline immunodeficiency virus (FIV) induces a disease similar to acquired immunodeficiency syndrome (AIDS) in cats, yet in contrast to human immunodeficiency virus (HIV), CD4 is not the viral receptor...
  42. ncbi Feline immunodeficiency virus env gene evolution in experimentally infected cats
    Martin Kraase
    Retrovirus Research Laboratory, Institute of Comparative Medicine, Faculty of Veterinary Medicine, University of Glasgow, Bearsden Road, Glasgow G61 1QH, United Kingdom
    Vet Immunol Immunopathol 134:96-106. 2010
    b>Feline immunodeficiency virus (FIV), an immunosuppressive lentivirus found in cats worldwide, is studied to illuminate mechanisms of lentiviral pathogenesis and to identify key components of protective immunity...
  43. pmc Lentivirus-induced immune dysregulation
    Mary B Tompkins
    Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, United States
    Vet Immunol Immunopathol 123:45-55. 2008
    ..As such, the natural history and pathogenesis provides an excellent model to study the long-term relationships between AIDS lentivirus and host immune system function/dysregulation...
  44. pmc Feline immunodeficiency virus OrfA is distinct from other lentivirus transactivators
    Udayan Chatterji
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Virol 76:9624-34. 2002
    The feline immunodeficiency virus (FIV) accessory factor, OrfA, facilitates transactivation of transcription directed by elements of the viral long terminal repeat (LTR)...
  45. ncbi The critical role of proximal gag sequences in feline immunodeficiency virus genome encapsidation
    Iris Kemler
    Molecular Medicine Program, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Virology 327:111-20. 2004
    ..b>Feline immunodeficiency virus (FIV) RNA encapsidation determinants have been shown to be discrete and noncontinuous, comprising one ..
  46. pmc Feline immunodeficiency virus ORF-Ais required for virus particle formation and virus infectivity
    Malou C Gemeniano
    Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, California 95616, USA
    J Virol 77:8819-30. 2003
    The orf-A (orf-2) gene of feline immunodeficiency virus (FIV) is a small open reading frame predicted to encode a 77-amino-acid protein that contains putative domains similar to those of the ungulate lentiviral Tat protein...
  47. pmc A dormant internal ribosome entry site controls translation of feline immunodeficiency virus
    Valentina Camerini
    Ecole Normale Superieure de Lyon, Unité de Virologie Humaine, IFR 128, Lyon F 69364, France
    J Virol 82:3574-83. 2008
    ..entry sites (IRESs) in virtually all lentiviruses prompted us to investigate the mechanism used by the feline immunodeficiency virus (FIV) to produce viral proteins...
  48. pmc Evolution of replication efficiency following infection with a molecularly cloned feline immunodeficiency virus of low virulence
    Margaret J Hosie
    Department of Veterinary Pathology, University of Glasgow, Glasgow G61 1QH, United Kingdom
    J Virol 76:6062-72. 2002
    ..with the domestic cat have demonstrated that vaccinal immunity to infection can be induced against feline immunodeficiency virus (FIV); however, protection is largely restricted to laboratory strains of FIV and does not extend to ..
  49. pmc Phylogenetic and genetic analysis of feline immunodeficiency virus gag, pol, and env genes from domestic cats undergoing nucleoside reverse transcriptase inhibitor treatment or treatment-naïve cats in Rio de Janeiro, Brazil
    Angelica N Martins
    Laboratory of Molecular Virology, Department of Genetics, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil
    J Virol 82:7863-74. 2008
    b>Feline immunodeficiency virus (FIV) is the Lentivirus responsible for an immunodeficiency-like disease in domestic cats (Felis catus). FIV is divided into five phylogenetic subtypes (A, B, C, D, and E), based on genetic diversity...
  50. ncbi Downmodulation of CD3epsilon expression in CD8alpha+beta- T cells of feline immunodeficiency virus-infected cats
    Yorihiro Nishimura
    Department of Veterinary Microbiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    J Gen Virol 85:2585-9. 2004
    b>Feline immunodeficiency virus (FIV) infection in cats is associated with an increase of feline CD (fCD)8alpha+beta- and fCD8alpha+beta low cells in peripheral blood...
  51. pmc In vivo depletion of CD4(+)CD25(hi) regulatory T cells is associated with improved antiviral responses in cats chronically infected with feline immunodeficiency virus
    S Rochelle Mikkelsen
    College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA
    Virology 403:163-72. 2010
    ..Lentivirus-induced CD4(+)CD25(hi) Treg cells were first described in feline immunodeficiency virus (FIV)-infected cats...
  52. ncbi Effect of feline immunodeficiency virus on cytokine response to Listeria monocytogenes in vivo
    G A Dean
    Department of Microbiology, Pathology, and Parasitology, College of Veterinary Medicine, North Carolina State University, Raleigh 27606, USA
    Vet Immunol Immunopathol 65:125-38. 1998
    b>Feline immunodeficiency virus (FIV) is a lentivirus that induces an acquired immunodeficiency in domestic cats...
  53. ncbi Methamphetamine enhances cell-associated feline immunodeficiency virus replication in astrocytes
    Mikhail A Gavrilin
    Department of Veterinary Clinical Sciences, College of Veterinary Medicine The Ohio State University, Columbus 43230, USA
    J Neurovirol 8:240-9. 2002
    ..Many Lentivirinae, including feline immunodeficiency virus (FIV), penetrate into the central nervous system early in the course of infection with astrocytes ..
  54. pmc Maternal hematological and virological characteristics during early feline immunodeficiency virus (FIV) infection of cats as predictors of fetal infection and reproductive outcome at early gestation
    Crystal E Boudreaux
    Department of Biological Sciences, Mississippi State University, Mississippi State, MS 39762, USA
    Vet Immunol Immunopathol 131:290-7. 2009
    ..However, maternal virological and hematological characteristics did not correlate either positively or negatively with reproductive outcome...
  55. pmc Feline immunodeficiency virus model for designing HIV/AIDS vaccines
    Janet K Yamamoto
    Department of Infectious Diseases and Pathology, College of Veterinary Medicine, University of Florida, P O Box 110880, Gainesville, FL 32611, USA
    Curr HIV Res 8:14-25. 2010
    b>Feline immunodeficiency virus (FIV) discovered in 1986 is a lentivirus that causes AIDS in domestic cats...
  56. pmc Acute mucosal pathogenesis of feline immunodeficiency virus is independent of viral dose in vaginally infected cats
    Kristina E Howard
    Center for Comparative Medicine and Translational Research, Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA
    Retrovirology 7:2. 2010
    ..The objective of this study was to determine the acute effect of viral dose on mucosal leukocytes and associated innate and adaptive immune responses...
  57. pmc Compartmentalization and evolution of feline immunodeficiency virus between the central nervous system and periphery following intracerebroventricular or systemic inoculation
    Pinghuang Liu
    Immunology Program, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, USA
    J Neurovirol 12:307-21. 2006
    ..c.v.) or intraperitoneal (i.p.) inoculation of animals with cell-free feline immunodeficiency virus (FIV)...
  58. ncbi CD134 and CXCR4 expression corresponds to feline immunodeficiency virus infection of lymphocytes, macrophages and dendritic cells
    F Reggeti
    Department of Pathobiology, University of Guelph, Guelph, ON N1G 2W1, Canada
    J Gen Virol 89:277-87. 2008
    The lymphotropic lentiviruses feline immunodeficiency virus (FIV) and human immunodeficiency virus (HIV) enter cells by sequential interaction with primary receptors CD134 or CD4, respectively, and subsequently with chemokine receptors...
  59. ncbi Natural antisense transcripts are detected in different cell lines and tissues of cats infected with feline immunodeficiency virus
    S Briquet
    INSERM U511, , , 75013 Paris, France
    Gene 267:157-64. 2001
    b>Feline immunodeficiency virus (FIV) is a lentivirus inducing an AIDS-like disease in cats, thus providing an interesting model for AIDS study...
  60. pmc Antiviral activity and conformational features of an octapeptide derived from the membrane-proximal ectodomain of the feline immunodeficiency virus transmembrane glycoprotein
    Simone Giannecchini
    Retrovirus Center and Virology Section, Department of Experimental Pathology, University of Pisa, I 56127 Pisa, Italy
    J Virol 77:3724-33. 2003
    b>Feline immunodeficiency virus (FIV) provides a valuable animal model by which criteria for lentivirus control strategies can be tested...
  61. ncbi Nonpathogenic lion and puma lentiviruses impart resistance to superinfection by virulent feline immunodeficiency virus
    Sue Vandewoude
    Department of Pathology, Colorado State University, Fort Collins, Colorado 80523 1671, USA
    J Acquir Immune Defic Syndr 29:1-10. 2002
    ..The feline immunodeficiency virus (FIV) is highly divergent from LLV and PLV and is pathogenic for domestic cats...
  62. pmc Molecular characterization of feline immunodeficiency virus budding
    Benjamin G Luttge
    Virus Cell Interaction Section, HIV Drug Resistance Program, NCI Frederick, Bldg 535, RM 108, Frederick, MD 21702 1201, USA
    J Virol 82:2106-19. 2008
    Infection of domestic cats with feline immunodeficiency virus (FIV) is an important model system for studying human immunodeficiency virus type 1 (HIV-1) infection due to numerous similarities in pathogenesis induced by these two ..
  63. pmc Cerebrospinal fluid is an efficient route for establishing brain infection with feline immunodeficiency virus and transfering infectious virus to the periphery
    Pinghuang Liu
    Immunology Program, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, USA
    J Neurovirol 12:294-306. 2006
    Like human immunodeficiency virus (HIV), feline immunodeficiency virus (FIV) invades and infects the central nervous system (CNS) soon after peripheral infection...
  64. ncbi Bold attitude makes male urban feral domestic cats more vulnerable to Feline Immunodeficiency Virus
    Eugenia Natoli
    Azienda USL Roma D, Area Dipartimentale Sanita Pubblica veterinaria, Ospedale Veterinario, via della Magliana 856, 00148 Roma, Italy
    Neurosci Biobehav Rev 29:151-7. 2005
    ..a high annual reproductive success but, on the other hand, to a high probability to be infected by the Feline Immunodeficiency Virus (FIV), a lethal disease caused by a retrovirus...
  65. ncbi Neutralization of feline immunodeficiency virus by antibodies targeting the V5 loop of Env
    Ayman Samman
    Retrovirus Research Laboratory, Institute of Comparative Medicine, Faculty of Veterinary Medicine, University of Glasgow, Bearsden, Glasgow G61 1QH, UK
    J Gen Virol 91:242-9. 2010
    Neutralizing antibodies (NAbs) play a vital role in vaccine-induced protection against infection with feline immunodeficiency virus (FIV)...
  66. pmc AIDS vaccination studies using an ex vivo feline immunodeficiency virus model: protection from an intraclade challenge administered systemically or mucosally by an attenuated vaccine
    Mauro Pistello
    Retrovirus Center and Virology Section, Department of Experimental Pathology, University of Pisa, Pisa, Italy
    J Virol 77:10740-50. 2003
    b>Feline immunodeficiency virus (FIV) infection of domestic cats represents a valuable system through which to investigate criteria for antilentiviral vaccines in a natural host species...
  67. pmc A single site for N-linked glycosylation in the envelope glycoprotein of feline immunodeficiency virus modulates the virus-receptor interaction
    Brian J Willett
    Retrovirus Research Laboratory, Institute of Comparative Medicine, Faculty of Veterinary Medicine, University of Glasgow, Bearsden Road, Glasgow, G61 1QH, UK
    Retrovirology 5:77. 2008
    b>Feline immunodeficiency virus (FIV) targets helper T cells by attachment of the envelope glycoprotein (Env) to CD134, a subsequent interaction with CXCR4 then facilitating the process of viral entry...
  68. ncbi Temperature sensitivity of two different steps in the viral life cycle of feline immunodeficiency virus
    C Alix
    Unité INSERM U74, Institut de Virologie de la Faculté de Médecine, 3, rue Koeberlé, Strasbourg, 67000, France
    Virology 253:309-18. 1999
    b>Feline immunodeficiency virus (FIV) multiplication is totally blocked by incubation of infected cells at 41 degrees...
  69. ncbi Hematology and serum biochemistry of feline immunodeficiency virus-infected and feline leukemia virus-infected cats
    S Gleich
    Clinic of Small Animal Internal Medicine, Ludwig Maximilian University Munich, Munich, Germany
    J Vet Intern Med 23:552-8. 2009
    Hematological and biochemical values in cats naturally infected by feline immunodeficiency virus (FIV) or feline leukemia virus (FeLV) are not completely documented.
  70. ncbi Feline immunodeficiency virus is concentrated in milk early in lactation
    Robin W Allison
    Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, Colorado 80523, USA
    AIDS Res Hum Retroviruses 19:245-53. 2003
    We studied mother-to-offspring transmission of feline immunodeficiency virus (FIV), focusing on milk-borne virus transmission in order to assess its similarities to perinatal HIV transmission...
  71. pmc Role of Env in resistance of feline immunodeficiency virus (FIV)-infected cats to superinfection by a second FIV strain as determined by using a chimeric virus
    Simone Giannecchini
    Retrovirus Center and Virology Section, Department of Experimental Pathology, University of Pisa, Via San Zeno, 37 I 56127 Pisa, Italy
    J Virol 81:10474-85. 2007
    ..We used a chimeric feline immunodeficiency virus (FIV), designated FIVchi, containing a large part of the env gene of a clade B virus (strain M2) and ..
  72. ncbi Evaluation of expression patterns of feline CD28 and CTLA-4 in feline immunodeficiency virus (FIV)-infected and FIV antigen-induced PBMC
    I S Choi
    Department of Infectious Diseases, College of Veterinary Medicine and School of Agricultural Biotechnology, Seoul National University, Suwon 441 744, Korea
    J Vet Sci 1:97-103. 2000
    ..CTLA-4 (CD152), however, acts as a negative regulator in T lymphocyte activation. The effect of an feline immunodeficiency virus (FIV) infection on the expression of feline CD28 and CTLA-4 was studied with FIV-infected and ..
  73. ncbi Prevalence of feline immunodeficiency virus infection in domesticated and feral cats in eastern Australia
    Jacqueline M Norris
    Faculty of Veterinary Science, Building B14, The University of Sydney, Sydney, NSW 2006, Australia
    J Feline Med Surg 9:300-8. 2007
    ..in eastern Australia, were collected over a 2-year period and tested for antibodies directed against feline immunodeficiency virus (FIV) using immunomigration (Agen FIV Rapid Immunomigration test) and enzyme-linked immunosorbent ..
  74. ncbi Feline immunodeficiency virus vector as a tool for preventative strategies against human breast cancer
    Laura Vannucci
    Retrovirus Center and Virology Section, Department of Experimental Pathology, University of Pisa, Pisa, Italy
    Vet Immunol Immunopathol 134:132-7. 2010
    ..We have produced a lentiviral vector from the feline immunodeficiency virus (FIV) to transduce wild type BRCA1 into primary mammary cells with a non-functional gene...
  75. pmc Construction and in vitro characterization of attenuated feline immunodeficiency virus long terminal repeat mutant viruses
    L Bigornia
    Departments of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, California 95616, USA
    J Virol 75:1054-60. 2001
    AP-1- and ATF-binding sites are cis-acting transcriptional elements within the U3 domain of the feline immunodeficiency virus (FIV) long terminal repeat (LTR) that serve as targets for cellular activation pathways and may regulate virus ..
  76. ncbi Feline programmed death and its ligand: characterization and changes with feline immunodeficiency virus infection
    A Folkl
    Department of Pathobiology, University of Guelph, Guelph, Ontario, Canada N1G 2W1
    Vet Immunol Immunopathol 134:107-14. 2010
    ..In vitro infection with the feline immunodeficiency virus (FIV) significantly decreased PD-1, but not PD-L1, gene expression in lymphocytes at 24h, and ..
  77. ncbi Virulence differences between two field isolates of feline immunodeficiency virus (FIV-APetaluma and FIV-CPGammar) in young adult specific pathogen free cats
    N C Pedersen
    Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    Vet Immunol Immunopathol 79:53-67. 2001
    The goal of this study was to identify a strain of feline immunodeficiency virus (FIV) that would be more virulent for adult cats than the prototype FIV-APetaluma and, thereby, enhance the FIV infection model for HIV-1 related research...
  78. ncbi Phenotypic changes in CD8+ peripheral blood lymphocytes in cats infected with feline immunodeficiency virus
    Masayuki Shimojima
    Department of Veterinary Microbiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Microbes Infect 5:1171-6. 2003
    ..We previously reported that feline immunodeficiency virus (FIV) infection induces a reduction in CD8beta chain expression of peripheral blood lymphocytes (PBLs) ..
  79. pmc Temporal association of large granular lymphocytosis, neutropenia, proviral load, and FasL mRNA in cats with acute feline immunodeficiency virus infection
    W S Sprague
    Colorado State University, Department of Microbiology, Immunology and Pathology, 1600 Campus Delivery, Fort Collins, CO, USA
    Vet Immunol Immunopathol 134:115-21. 2010
    During acute feline immunodeficiency virus-C(PGammar) (FIV-C-PG) infection, we observed that cats develop large granular lymphocyte (LGL) lymphocytosis concurrent with a marked neutropenia that is temporally associated with the rise and ..
  80. ncbi Evidence of feline immunodeficiency virus, feline leukemia virus, and Toxoplasma gondii in feral cats on Mauna Kea, Hawaii
    Raymond M Danner
    Pacific Cooperative Studies Unit, University of Hawaii at Manoa, c o USGS Pacific Island Ecosystems Research Center, Kilauea Field Station, Hawaii National Park, HI 96718, USA
    J Wildl Dis 43:315-8. 2007
    We determined prevalence to feline immunodeficiency virus (FIV) antibodies, feline leukemia virus (FeLV) antigen, and Toxoplasma gondii antibodies in feral cats (Felis catus) on Mauna Kea Hawaii from April 2002 to May 2004. Six of 68 (8...
  81. ncbi Feline immunodeficiency virus plasma load reduction by a retroinverso octapeptide reproducing the Trp-rich motif of the transmembrane glycoprotein
    Simone Giannecchini
    Retrovirus Centre and Virology Section, Department of Experimental Pathology, University of Pisa, Pisa, Italy
    Antivir Ther 10:671-80. 2005
    ..We recently demonstrated that an octapeptide reproducing the TrpM of feline immunodeficiency virus (FIV), designated C8, broadly inhibited this virus in vitro and that the retroinverso analogue of this ..
  82. ncbi Feline immunodeficiency virus integration in B-cell lymphoma identifies a candidate tumor suppressor gene on human chromosome 15q15
    Julia Beatty
    Molecular Oncology Laboratory, Institute of Comparative Medicine, University of Glasgow Veterinary School, Bearsden, Glasgow, Scotland
    Cancer Res 62:7175-80. 2002
    ..An exception wasfound in a B-cell lymphoma (Q254) where the tumor cells contained a single integrated feline immunodeficiency virus genome...
  83. ncbi Domestic cats infected with lion or puma lentivirus develop anti-feline immunodeficiency virus immune responses
    Sue Vandewoude
    Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, 80523 1619, USA
    J Acquir Immune Defic Syndr 34:20-31. 2003
    ..PLV) or lion lentivirus (LLV) conferred partial protection against superinfection with virulent feline immunodeficiency virus (FIV), the feline equivalent of HIV...
  84. ncbi Plasma electrophoretogram in feline immunodeficiency virus (FIV) and/or feline leukaemia virus (FeLV) infections
    G Miro
    Departamento de Sanidad Animal, Facultad de Veterinaria, Universidad Complutense, Madrid, Spain
    J Vet Med A Physiol Pathol Clin Med 54:203-9. 2007
    The electrophoretogram of 89 cats, including those infected by feline immunodeficiency virus (FIV+), feline leukaemia virus (FeLV+) and non-infected, showed statistically significant differences in several of the fractions...
  85. pmc Optimization of feline immunodeficiency virus vectors for RNA interference
    Scott Q Harper
    Program in Gene Therapy, University of Iowa, Iowa City, IA 52242, USA
    J Virol 80:9371-80. 2006
    ..Here, we tested the hypothesis that vectors based on feline immunodeficiency virus (FIV) could be used for coexpression of reporter constructs and RNAi expression cassettes...
  86. ncbi Mucosal infection and vaccination against feline immunodeficiency virus
    C R Stokes
    Division of Molecular and Cellular Biology, University of Bristol, UK
    J Biotechnol 73:213-21. 1999
    b>Feline immunodeficiency virus (FIV) infection is a naturally occurring lentiviral infection of cats which progresses to immunodeficiency in a manner strikingly similar to that observed in HIV infection in man...
  87. pmc C-Terminal gp40 peptide analogs inhibit feline immunodeficiency virus: cell fusion and virus spread
    R J Medinas
    Immunology Program, North Carolina State University, Raleigh 27606, USA
    J Virol 76:9079-86. 2002
    ..b>Feline immunodeficiency virus (FIV) infection in the cat has been used as a model to develop potential antivirals for HIV...
  88. ncbi Inhibitory RNA ligand to reverse transcriptase from feline immunodeficiency virus
    H Chen
    Department of Molecular, University of Colorado at Boulder 80309, USA
    Biochemistry 35:6923-30. 1996
    High-affinity, high-specificity RNA ligands for reverse transcriptase from feline immunodeficiency virus (FIV) were isolated from an RNA library by the SELEX (Systematic Evolution of Ligands by EXponential enrichment) procedure...
  89. ncbi Cytokine modulation of the innate immune response in feline immunodeficiency virus-infected cats
    Gregg A Dean
    Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, 27606, USA
    J Infect Dis 193:1520-7. 2006
    ..b>Feline immunodeficiency virus (FIV) infection in cats provides an excellent model to explore innate immune function in vivo...
  90. ncbi The feline immunodeficiency virus-infected cat: a model for lentivirus-induced placental immunopathology and reproductive failure (mini-review)
    Karen S Coats
    Department of Biological Sciences and College of Veterinary Medicine, Mississippi State University, PO Box GY, MS 39762, USA
    Am J Reprod Immunol 54:169-85. 2005
    ..Transplacental transmission is readily achieved experimentally, resulting in a high proportion of infected offspring and frequent reproductive failure...
  91. ncbi Constitutive expression of types 1 and 2 cytokines by alveolar macrophages from feline immunodeficiency virus-infected cats
    J W Ritchey
    Department of Microbiology, Pathology, and Parasitology, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, 27606, Raleigh, NC, USA
    Vet Immunol Immunopathol 79:83-100. 2001
    Evidence suggests that feline immunodeficiency virus (FIV), causes pulmonary immunodeficiency...
  92. ncbi Feline immunodeficiency virus-mediated viral interleukin-10 gene transfer prolongs non-vascularized cardiac allograft survival
    Shuang Fu
    Carl C Icahn Institute for Gene Therapy and Molecular Medicine, and Recanati Miller Transplantation Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    Am J Transplant 3:552-61. 2003
    ..b>Feline immunodeficiency virus (FIV) can integrate into genomic DNA of nondividing cells, resulting in indefinite transgene ..
  93. pmc Antiretroviral spermicide WHI-07 prevents vaginal and rectal transmission of feline immunodeficiency virus in domestic cats
    OSMOND J D'CRUZ
    Drug Discovery Program, Parker Hughes Institute, St Paul, Minnesota 55113, USA
    Antimicrob Agents Chemother 48:1082-8. 2004
    ..WHI-07 was active against the feline immunodeficiency virus (FIV)...
  94. ncbi TNF-alpha-induced cell death in feline immunodeficiency virus-infected cells is mediated by the caspase cascade
    T Mizuno
    Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo, 113 8657, Japan
    Virology 287:446-55. 2001
    ..The present study indicates that TNF-alpha-induced apoptosis in FIV-infected CRFK cells is mediated by the activation of the caspase cascade, but not by either upregulation of TNF receptor or inhibition of NF-kappaB...
  95. pmc Neurovirulence in feline immunodeficiency virus-infected neonatal cats is viral strain specific and dependent on systemic immune suppression
    C Power
    Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta T2N 4N1 Canada
    J Virol 72:9109-15. 1998
    b>Feline immunodeficiency virus (FIV) is a lentivirus that causes immune suppression and neurological disease in cats...
  96. pmc The secondary structure of the 5' end of the FIV genome reveals a long-range interaction between R/U5 and gag sequences, and a large, stable stem-loop
    Julia C Kenyon
    Department of Medicine, Addenbrooke s Hospital, University of Cambridge, Cambridge CB2 2QQ, United Kingdom
    RNA 14:2597-608. 2008
    b>Feline immunodeficiency virus (FIV) is a lentivirus that infects cats and is related to human immunodeficiency virus (HIV)...
  97. ncbi Evaluation of the association of Bartonella species, feline herpesvirus 1, feline calicivirus, feline leukemia virus and feline immunodeficiency virus with chronic feline gingivostomatitis
    Jessica M Quimby
    College of Veterinary Medicine and Biomedical Sciences, Colorado State University, 300 West Drake Road, Fort Collins, CO 80523, USA
    J Feline Med Surg 10:66-72. 2008
    ..Serum was tested for feline leukemia virus (FeLV) antigen and antibodies against feline immunodeficiency virus, feline calicivirus (FCV), feline herpesvirus 1 (FHV-1), and Bartonella species (enzyme-linked ..
  98. ncbi Lymphocyte migration through the blood-brain barrier (BBB) in feline immunodeficiency virus infection is significantly influenced by the pre-existence of virus and tumour necrosis factor (TNF)-alpha within the central nervous system (CNS): studies using a
    N F Fletcher
    University College Dublin, Ireland
    Neuropathol Appl Neurobiol 35:592-602. 2009
    ..Some knowledge exists on macrophage-tropic virus interactions with the blood-brain barrier (BBB), and the aim of this study was to investigate lymphotropic lentivirus interactions with the BBB...
  99. ncbi Design and synthesis of membrane fusion inhibitors against the feline immunodeficiency virus
    Shinya Oishi
    Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    Bioorg Med Chem 17:4916-20. 2009
    b>Feline immunodeficiency virus (FIV) is a pathogenic virus that causes an AIDS-like syndrome in the domestic cats...
  100. ncbi Pathogenesis of a Texas feline immunodeficiency virus isolate: an emerging subtype of clade B
    Anagha P Phadke
    Department of Biology, Texas A and M University, College Station, TX 77843 3258, United States
    Vet Microbiol 115:64-76. 2006
    We have recently provided evidence that Texas feline immunodeficiency virus (FIV-TX) isolates are an emerging subtype sharing a common ancestry with clade B isolates...
  101. ncbi Feline immunodeficiency virus envelope glycoprotein mediates apoptosis in activated PBMC by a mechanism dependent on gp41 function
    Himanshu Garg
    Immunology Program, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA
    Virology 330:424-36. 2004
    b>Feline Immunodeficiency Virus (FIV) is a lentivirus that causes immunodeficiency in cats, which parallels HIV-1-induced immunodeficiency in humans...

Research Grants67

  1. Placental Treg Activation and Pregnancy Outcome in the FIV-infected Cat Model
    GREGORY TODD PHARR; Fiscal Year: 2010
    ..The purpose of this project is to evaluate the effect of HIV infection on the function of regulatory T cells, using the feline immunodeficiency virus (FIV)-infected cat to model maternal-fetal infection and compromised pregnancy.
  2. PERIPHERAL NEUROPATHY IN LENTIVIRUS INFECTIONS: EARLY VIRAL AND HOST DETERMINANTS
    Christopher Power; Fiscal Year: 2010
    ..Lentiviruses including HIV-1 and feline immunodeficiency virus (FIV) cause immunosuppression and neurological disease defined by the development of DSP...
  3. Quantifying cognitive-motor decline in FIV-infected cats
    Lola C Hudson; Fiscal Year: 2010
    ..b>Feline immunodeficiency virus (FIV) offers an alternative model of lentiviral neuropathogenesis which recapitulates all essential ..
  4. MOLECULAR CHARACTERIZATION OF FIV
    John H Elder; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Feline immunodeficiency virus (FIV) causes AIDS in the domestic cat with many similarities to AIDS in humans...
  5. Protective CMI mechanisms of a dual-subtype FIV vaccine
    Janet K Yamamoto; Fiscal Year: 2012
    ..PROJECT NARRATIVE Over 1.8 million doses of commercial feline immunodeficiency virus (FIV) vaccine have been sold since July 2002 without any cases of vaccine failure...
  6. Development of Molecular Imaging Technology Visualizing Viral Reservoirs in Vivo
    Won Bin Young; Fiscal Year: 2013
    ..The principle of our technology is engineering a replication-competent lentivirus, such as simian or feline immunodeficiency virus (SIV or FIV), with reporter genes in its genome, thus, each infected cell will express reporters ..
  7. Evolution of Dendritic Cell Dysfunction in FIV Infection
    TRACY L WEBB; Fiscal Year: 2012
    ..The proposed researchexamines the immune response to lentiviral infection using the feline immunodeficiency virus (FIV) model, specifically evaluating the effects of FIV on myeloid dendritic cells (mDCs)...
  8. Novel brain-penetrant fusion inhibitors for control of CNS infection.
    Matteo Porotto; Fiscal Year: 2012
    ..We propose here to assess the potential of cholesterol-tagged FI to treat retroviral infection of the CNS, using feline Immunodeficiency Virus (FIV) as a unique and credible model for neuro-AIDS.
  9. INCIDENTAL INFECTIOUS DISEASES AS COFACTORS
    Niels Pedersen; Fiscal Year: 1993
    ..This aspect of HIV infection can be better studied using an appropriate animal model. Feline Immunodeficiency Virus (FIV) infection might provide such a model...
  10. RRE LINKED MUCOSAL BARRIER TO LENTIVIRUS INFECTION
    Margaret Barr; Fiscal Year: 2000
    b>Feline immunodeficiency virus, a lentivirus of cats, provides a natural model for human immunodeficiency virus (HIV) infection and disease...
  11. Stampidine: A Novel Broad-Spectrum Antiviral Agent
    Taracad Venkatachalam; Fiscal Year: 2003
    ..We are now proposing studies aimed at evaluating the safety and efficacy of STAMP against the feline immunodeficiency virus (FIV) infection in domestic cats, an established model for HIV-1 infection in man...
  12. Hemophilia A: Intrathymic Delivery for Tolerance and Longterm Expression of FVIII
    William Raschke; Fiscal Year: 2007
    ..With respect to the delivery system, a non-primate lentiviral vector derived from Feline Immunodeficiency Virus (FIV) provides excellent transduction efficiency of a variety of cells and organs including stromal ..
  13. Stampidine: A Novel Broad-Spectrum Anti-HIV Microbicide
    OSMOND D CRUZ; Fiscal Year: 2005
    ..of STAMP >4-logs higher than its IC50 value and exhibited potent antiretroviral activity in feline immunodeficiency virus (FlV)-infected cats...
  14. RECOMBINANT LISTERIA--BIOLOGIC VACCINE VECTOR FOR FIV
    Gregg Dean; Fiscal Year: 2001
    ..These studies will be performed using the feline immunodeficiency virus (FIV) infection of cats as a model for HIV infection of people...
  15. PATHOGENESIS OF FELINE IMMUNODEFICIENCY VIRUS--AIDS
    Wayne Tompkins; Fiscal Year: 1993
    ..The investigators have demonstrated that cats naturally or experimentally infected with Feline Immunodeficiency Virus (FIV) also show an inverted CD4+:CD8+ ratio due to decreased numbers of CD4+ cells...
  16. MARROW SUPPRESSION FROM A LENTIVIRUS
    JANIS ABKOWITZ; Fiscal Year: 1993
    ..In addition, as FTLV does not infect human cells or cell lines, these studies involve less biohazard than cell culture studies with blood or marrow from AIDS patients...
  17. ENDOMEMBRANE TRAFFICKING OF FIV ENVELOPE GLYCOPROTEINS
    D Morre; Fiscal Year: 1993
    ..as a strategy for target identification in antiviral drug design using cultured cells infected with feline immunodeficiency virus (FIV)...
  18. Evaluation of thymus function in lentivirus disease
    Lawrence Mathes; Fiscal Year: 2009
    ..b>Feline immunodeficiency virus (FIV) infection of cats leads to significant pathological changes in the thymus with many similar ..
  19. Vanadocenes as a New Class of Spermicidal Drugs
    OSMOND D CRUZ; Fiscal Year: 2007
    ..VDDTC significantly enhanced the microbicide efficacy of the antiretroviral spermicide WHI- 07 in the feline immunodeficiency virus/cat model of AIDS...
  20. Choroid plexus macrophages in FIV neuropathogenesis
    RICK MEEKER; Fiscal Year: 2009
    ..b>Feline immunodeficiency virus (FIV) offers an alternative model of lentiviral neuropathogenesis which recapitulates all essential ..
  21. Characterization of cell clones resistant to HIV
    Richard Sutton; Fiscal Year: 2007
    ..leucosis virus, human foamy virus, bovine immunodeficiency virus, equine infectious anemia virus, feline immunodeficiency virus, and SIV...
  22. Feline Immunodeficiency Virus Orf-A a Model for HIV Vpr
    Ellen Sparger; Fiscal Year: 2007
    The feline immunodeficiency virus (FIV) animal model presents a unique and significant opportunity for assessing novel antiviral strategies for HIV/AIDS in humans...
  23. SIV delta vif DNA Vaccines with Cytokine Adjuvants
    Ellen Sparger; Fiscal Year: 2004
    ..We have been investigating live-attenuated feline immunodeficiency virus (FIV) vaccines for inducing protective immunity in cats (Preliminary Results)...
  24. AIDS DEMENTIA--MOLECULAR AND CELLULAR MECHANISMS
    Floyd Bloom; Fiscal Year: 2000
    ..and immunological manifestations of infection with Simian Immunodeficiency Virus (SIV), and Feline Immunodeficiency Virus (FIV) as well as transgenic mice over- expressing either the cytokines mediating inflammatory and ..
  25. FIV-MD AS A MODEL FOR AGE-DEPENDENT NEURO-AIDS
    Michael Podell; Fiscal Year: 1999
    ..neuropathogenesis of lentiviral infection of the brain using the neurotropic Maryland isolate of the feline immunodeficiency virus (FIV-MD) as a model in experimentally infected cats...
  26. Lentiviral Genome Processing
    Eric Poeschla; Fiscal Year: 2003
    ..The laboratory studies HIV-1 and feline immunodeficiency virus (FIV)...
  27. Functional Analysis of FIV ORF-A
    Ayalew Mergia; Fiscal Year: 2004
    DESCRIPTION (provided by applicant):Feline immunodeficiency virus (FIV), a lentivirus of cats, causes an AIDS similar to what is seen in humans with human immunodeficiency virus (HIV)...
  28. MECHANISMS OF RETROVIRUS-INDUCED NEURAL DYSFUNCTION
    Steven Dow; Fiscal Year: 1993
    ..vitro and in vivo systems and molecularly cloned feline retroviruses (feline leukemia virus {FeLV} and feline immunodeficiency virus {FIV}) to develop models for study of retrovirus- induced neurologic disease...
  29. IN VIVO IMMUNE ACTIVATION/ FIV GENE EXPRESSION
    Satya Dandekar; Fiscal Year: 1992
    ..antigens, and incidental infections in inducing or enhancing HIV gene expression in vivo by using feline immunodeficiency virus (FIV)-infected cats as a small animal model for human AIDS...
  30. FELINE IMMUNODEFICIENCY VIRUS GENE EXPRESSION
    Paul Luciw; Fiscal Year: 1993
    b>Feline immunodeficiency virus (FIV) is a lymphocytopathic lentivirus associated with fatal immunodeficiency in cats...
  31. FIV MODEL OF VERTICAL HIV TRANSMISSION AND INTERVENTION
    Robin Allison; Fiscal Year: 2003
    ..We propose to use an established feline immunodeficiency virus (FIV) model of mother-to-offspring lentivirus transmission to investigate perinatal HIV treatment ..
  32. IMMUNITY INDUCED BY AVIRULENT LENTIVIRUSES
    Sue Vandewoude; Fiscal Year: 2001
    This proposal addressess immunological and intracellular mechanisms of protection against feline immunodeficiency virus (FIV) infection provided by previous exposure to an apathogenic strain of FIV of puma origin (FIV-Pco)...
  33. Viral Mediated Gene Therapy for Retinal Diseases
    John Flannery; Fiscal Year: 2005
    ..Viral vectors derived from adeno-associated virus (AAV) and feline immunodeficiency virus (FIV) will be used for transfer of neurotrophin genes to the retina...
  34. STRATEGIES TO ENHANCE GENE TRANSFER TO THE CNS
    Beverly Davidson; Fiscal Year: 2009
    ..Thus, directed application of enzyme to the brain is required. We hypothesize that recombinant feline immunodeficiency virus (FIV) vectors can be developed and used to complement the enzyme deficiency and accompanying CNS ..
  35. IFN-tau treatment in mice infected with cowpox virus
    Lorelie Villarete; Fiscal Year: 2004
    ..viral replication of human papillomavirus, human immunodeficiency virus, human hepatitis B virus and feline immunodeficiency virus, and murine Theiler's virus...
  36. WHI-07: A Novel Dual-Function Microbicide
    OSMOND D CRUZ; Fiscal Year: 2002
    ..I proposal is to test: (i) the ability of WHI-07 gel formulation to prevent vaginal transmission of feline immunodeficiency virus in domestic cats as a model for sexual transmission of HIV; and (ii) to determine the developmental ..
  37. INITIAL EVENTS IN TRANSMUCOSAL LENTIVIRUS INFECTION
    AMY RULLKOETTER; Fiscal Year: 2000
    ..The applicant proposes to use an established feline immunodeficiency virus (FIV) model of transvaginal lentivirus infection to investigate the initial events in mucosal ..
  38. ALVEOLAR MACROPHAGES IN FIV INFECTION
    JERRY RITCHEY; Fiscal Year: 2000
    ..Evidence suggests that the feline AIDS-causing lentivirus, Feline Immunodeficiency Virus (FIV) causes serious pulmonary immunodeficiency characterized by increased susceptibility to ..
  39. Global Gene Functional Analysis with siRNA Libraries
    Alex Chenchik; Fiscal Year: 2006
    ..Under Phase I funding, the biosafe feline immunodeficiency virus (FIV) lentiviral siRNA cloning vectors and technology for construction of high complexity siRNA ..
  40. Non-Primate FIV Vectors for Treatment of Hemophilia A
    Sybille Sauter; Fiscal Year: 2002
    We propose to optimize non-primate Feline Immunodeficiency Virus (FIV) vectors for the treatment of hemophilia A to address the need for constitutive, long-term expression of the therapeutic protein, factor VIII...
  41. LENTIVIRUS-INDUCED NEUROPATHY: VIRAL DIVERSITY AND HOST*
    Christopher Power; Fiscal Year: 2004
    ..to the development of DSP, using multiple infectious biological strains and recombinant viruses of feline immunodeficiency virus (FIV)...
  42. FIV Vectors for the Treatment of Hemophilia A
    Sybille Sauter; Fiscal Year: 2005
    ..Lentiviral vectors overcome both problems and our cumulative preclinical studies using Feline Immunodeficiency Virus (FIV)-based lentiviral vectors resulted in persistent and therapeutic FVIII expression levels in the ..
  43. ANTIVIRAL AGENTS EFFECTS ON IMMUNE FUNCTIONS
    Lawrence Mathes; Fiscal Year: 2000
    DESCRIPTION: (Adapted from applicant's abstract) The applicants propose to utilize the feline immunodeficiency virus (FIV) cat animal model for AIDS to develop a better understanding of the pathogenesis of lentivirus-mediated thymic ..
  44. REGULATED FIV VECTORS FOR VACCINATION
    Ellen Sparger; Fiscal Year: 2000
    DESCRIPTION: (Adapted from Applicant's Abstract) Infection of cats with the feline immunodeficiency virus (FIV) produces an immunodeficiency syndrome with pathogenesis very similar to that observed in people infected with human ..
  45. CEA DENTRITIC CELL VACCINE FOR COLORECTAL CANCER
    Frank Scappaticci; Fiscal Year: 2002
    ..This project will use recombinant adeno-associated virus (AAV) or feline immunodeficiency virus (FIV) to deliver the CEA gene to murine dendritic cells in vitro...
  46. FIV MODEL OF PERINATAL HIV INFECTION AND INTERVENTION
    Edward Hoover; Fiscal Year: 2000
    DESCRIPTION (Adapted from investigator's abstract): The investigators propose to use feline immunodeficiency virus (FIV) mother-to-offspring transmission to investigate aspects of HIV perinatal transmission and intervention that are ..
  47. FIV MODEL OF IN UTERO HIV INFECTION AND INTERVENTION
    ARLIN ROGERS; Fiscal Year: 2000
    The objective of this research is to investigate pathogenetic mechanisms of transplacental feline immunodeficiency virus (FIV) transmission as a guide towards better understanding antenatal mother-to-infant HIV-1 transmission...
  48. TYPE 1 VS TYPE 2 CYTOKINE RESPONSE DURING FIV INFECTION
    Paul Avery; Fiscal Year: 2000
    DESCRIPTION: (Adapted from the application abstract) Using a strain of feline immunodeficiency virus (FIV) that induces rapid disease, the applicant will examine whether a cytokine profile switch from a Type 1 to a Type 2 response occurs ..
  49. A Lentivirus Vaccine for HIV
    Sybille Sauter; Fiscal Year: 2002
    ..HIV immunogen (HIVgag/pol/tatnf/rev) in a non-human lentiviral system (Lenti-HIV) based on the feline immunodeficiency virus. This vaccine will not only safely mimic HIV infection, but will present a broad number of safe viral ..
  50. PROPHYLAXIS OF FETAL HEMATOPOIETIC CELLS FOR FIV
    Ayalew Mergia; Fiscal Year: 2002
    ..The animal model system we will employ is the feline immunodeficiency virus (FIV) in cats...
  51. BONE MARROW CELL ADHESION MOLECULES
    PAUL KINCADE; Fiscal Year: 2001
    ..being studied in this project may contribute to the attachment of poliovirus, the AIDS virus, feline immunodeficiency virus and diphtheria toxin to cells...
  52. FT Fidelity and Evolution of FIV and FeLV
    DARWIN OPERARIO; Fiscal Year: 2007
    ..This hypothesis will be tested using RTs from two retroviruses feline immunodeficiency virus (FIV) and feline leukemia virus (FeLV), which are isolated from a single host species.
  53. PSYCHOSTIMULANTS AND LENTIVIRAL INFECTION OF NEURAL CELL
    Lawrence Mathes; Fiscal Year: 2004
    ..neurodegeneration associated with immunodeficiency, behavioral disturbances, and neuronal loss after feline immunodeficiency virus (FIV) infection...
  54. PEPTIDE INHIBITORS OF CA++--THERAPEUTIC AGENTS FOR AIDS
    J Blalock; Fiscal Year: 1999
    ..CALP also blocks lymphocytotoxicity and apoptosis in feline immunodeficiency virus (FIV)-infected cat peripheral blood mononuclear cells...
  55. Filovirus enveloped FIV:virus-epithelia interactions-CF
    Paul McCray; Fiscal Year: 2007
    ..Our work focuses on the development and application of recombinant lentiviral vectors based on feline immunodeficiency virus (FIV) to surmount these problems...
  56. Non-Integrating FIV Vectors for HIV Vaccines
    William Raschke; Fiscal Year: 2007
    ..retro-, lentiviral vectors), we propose to explore a novel non-integrating lentiviral vector based on Feline Immunodeficiency Virus (FIV) which can address these shortcomings of the current vector...
  57. ANTITUMOR AND ANTI HIV ACTIVITY OF A NOVEL INTERFERON
    Carol Pontzer; Fiscal Year: 1992
    ..interferon (IFNalpha), ovine trophoblast protein-1 (oTP-1), as well as its activity against human and feline immunodeficiency virus (HIV, FIV) infections...
  58. A Lentivirus Vaccine for HIV
    Sybille Sauter; Fiscal Year: 2004
    ..safe, disabled HIV immunogen (HIV gag/pol/tatnf/rev) in a non-human lentiviral system based on the feline immunodeficiency virus. This vaccine will not only safely mimic HIV infection, but will present a broad number of safe viral ..
  59. Receptor usage and pathogenicity of feline lentiviruses
    BRIAN WILLETT; Fiscal Year: 2007
    ..that CXCR-4 and CD134 are the major co-receptor and primary binding receptor respectively for feline immunodeficiency virus (FIV), the lentivirus of the domestic cat...
  60. FIV PENETRATION AND PERSISTENCE IN NEONATAL CAT BRAIN
    RICK MEEKER; Fiscal Year: 2001
    ..We will use feline immunodeficiency virus (FIV) as an animal model of HIV-induced CNS disease to examine virus penetration and cytokine and ..
  61. Development of Neuronal gene therapy for HIV-dementia
    Shilpa Buch; Fiscal Year: 2006
    ..We will use the unique approach of feline immunodeficiency virus (FFV) based lentivirus vectors (2) to transduce the neurons adjacent to the white matter tract in the ..
  62. PATHOGENESIS OF FELINE IMMUNODEFICIENCY VIRUS INFECTION
    Edward Hoover; Fiscal Year: 2008
    ..b>Feline immunodeficiency virus (FIV), the feline counterpart of HIV and SIV, is transmissible by vaginal, rectal, or oral exposure ..
  63. Joint degeneration: Somatic mosaic analysis in a transgenic mouse
    Stephanos Kyrkanides; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  64. In vivo significance of T-reg cells during FIV infection
    Gregg Dean; Fiscal Year: 2006
    ..have described CD4+CD25+ Treg cells in the cat and demonstrated that they are chronically activated in feline immunodeficiency virus (FIV) infected animals...
  65. Recombinant Listeria: A Biologic Vaccine Vector For FIV
    Gregg Dean; Fiscal Year: 2004
    ..Thus, it is seems reasonable to pursue novel vaccine strategies in the well characterized feline immunodeficiency virus (FIV)/cat model...
  66. BASIS AND MODULATION OF THE INNATE IMMUNE DEFECT IN FIV
    Gregg A Dean; Fiscal Year: 2010
    ..Together these studies will elucidate the cellular mechanisms that underlie the innate immune defect and investigate potential molecular mechanisms. ..