feline immunodeficiency virus

Summary

Summary: A species of LENTIVIRUS, subgenus feline lentiviruses (LENTIVIRUSES, FELINE) isolated from cats with a chronic wasting syndrome, presumed to be immune deficiency. There are 3 strains: Petaluma (FIP-P), Oma (FIP-O) and Puma lentivirus (PLV). There is no antigenic relationship between FIV and HIV, nor does FIV grow in human T-cells.

Top Publications

  1. ncbi Pathological manifestations of feline immunodeficiency virus (FIV) infection in wild African lions
    Melody E Roelke
    Laboratory of Genomic Diversity, SAIC Frederick, Inc, NCI Frederick, Frederick, MD, USA
    Virology 390:1-12. 2009
  2. ncbi Going wild: lessons from naturally occurring T-lymphotropic lentiviruses
    Sue Vandewoude
    Department of Microbiology, Immunology and Pathology, College of Veterinary and Biomedical Sciences, Colorado State University, Fort Collins, CO 80538-1619, USA
    Clin Microbiol Rev 19:728-62. 2006
  3. ncbi Feline immunodeficiency virus (FIV) as a model for study of lentivirus infections: parallels with HIV
    John H Elder
    Department of Immunology and Microbial Sciences, The Scripps Research Institute, La Jolla, CA 92037, USA
    Curr HIV Res 8:73-80. 2010
  4. ncbi Use of CD134 as a primary receptor by the feline immunodeficiency virus
    Masayuki Shimojima
    Department of Veterinary Microbiology, Graduate School of Agricultural and Life Sciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Science 303:1192-5. 2004
  5. ncbi Virulence differences between two field isolates of feline immunodeficiency virus (FIV-APetaluma and FIV-CPGammar) in young adult specific pathogen free cats
    N C Pedersen
    Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    Vet Immunol Immunopathol 79:53-67. 2001
  6. ncbi Preferential feline immunodeficiency virus (FIV) infection of CD4+ CD25+ T-regulatory cells correlates both with surface expression of CXCR4 and activation of FIV long terminal repeat binding cellular transcriptional factors
    Anjali Joshi
    Immunology Program, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina 27606, USA
    J Virol 79:4965-76. 2005
  7. ncbi OrfA downregulates feline immunodeficiency virus primary receptor CD134 on the host cell surface and is important in viral infection
    Yang Hong
    Department of Immunology and Microbial Science, The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, CA 92037, USA
    J Virol 84:7225-32. 2010
  8. ncbi Vif of feline immunodeficiency virus from domestic cats protects against APOBEC3 restriction factors from many felids
    Jörg Zielonka
    Clinic for Gastroenterology, Hepatology and Infectiology, Heinrich Heine University, Building 23 12 U1 87, Moorenstr 5, 40225 Dusseldorf, Germany
    J Virol 84:7312-24. 2010
  9. ncbi Functional interactions of nucleocapsid protein of feline immunodeficiency virus and cellular prion protein with the viral RNA
    Mila Moscardini
    Department of Biomedicine, University of Pisa, I-56127 Pisa, Italy
    J Mol Biol 318:149-59. 2002
  10. ncbi Mapping the encapsidation determinants of feline immunodeficiency virus
    Iris Kemler
    Molecular Medicine Program, Departments of Immunology and Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Virol 76:11889-903. 2002

Research Grants

  1. Stampidine: A Novel Broad-Spectrum Antiviral Agent
    Taracad Venkatachalam; Fiscal Year: 2003
  2. PERIPHERAL NEUROPATHY IN LENTIVIRUS INFECTIONS: EARLY VIRAL AND HOST DETERMINANTS
    Christopher Power; Fiscal Year: 2010
  3. Stampidine: A Novel Broad-Spectrum Anti-HIV Microbicide
    OSMOND D CRUZ; Fiscal Year: 2005
  4. Molecular Analysis of FIV
    John Elder; Fiscal Year: 2007
  5. Evaluation of thymus function in lentivirus disease
    Lawrence Mathes; Fiscal Year: 2005
  6. Evaluation of thymus function in lentivirus disease
    Lawrence Mathes; Fiscal Year: 2009
  7. Vanadocenes as a New Class of Spermicidal Drugs
    OSMOND D CRUZ; Fiscal Year: 2007
  8. Choroid plexus macrophages in FIV neuropathogenesis
    RICK MEEKER; Fiscal Year: 2009
  9. Choroid plexus macrophages in FIV neuropathogenesis
    RICK MEEKER; Fiscal Year: 2007
  10. Lentiviral Genome Processing
    Eric Poeschla; Fiscal Year: 2007

Detail Information

Publications267 found, 100 shown here

  1. ncbi Pathological manifestations of feline immunodeficiency virus (FIV) infection in wild African lions
    Melody E Roelke
    Laboratory of Genomic Diversity, SAIC Frederick, Inc, NCI Frederick, Frederick, MD, USA
    Virology 390:1-12. 2009
    b>Feline immunodeficiency virus (FIV) causes AIDS in the domestic cat (Felis catus) but has not been explicitly associated with AIDS pathology in any of the eight free-ranging species of Felidae that are endemic with circulating FIV ..
  2. ncbi Going wild: lessons from naturally occurring T-lymphotropic lentiviruses
    Sue Vandewoude
    Department of Microbiology, Immunology and Pathology, College of Veterinary and Biomedical Sciences, Colorado State University, Fort Collins, CO 80538-1619, USA
    Clin Microbiol Rev 19:728-62. 2006
    ..more than 20 species of nondomestic felids and African hyenids demonstrate seroreactivity against feline immunodeficiency virus (FIV) antigens...
  3. ncbi Feline immunodeficiency virus (FIV) as a model for study of lentivirus infections: parallels with HIV
    John H Elder
    Department of Immunology and Microbial Sciences, The Scripps Research Institute, La Jolla, CA 92037, USA
    Curr HIV Res 8:73-80. 2010
    ..The following review highlights both the strengths and shortcomings of the FIV/cat model, particular as regards development of antiviral drugs...
  4. ncbi Use of CD134 as a primary receptor by the feline immunodeficiency virus
    Masayuki Shimojima
    Department of Veterinary Microbiology, Graduate School of Agricultural and Life Sciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Science 303:1192-5. 2004
    b>Feline immunodeficiency virus (FIV) induces a disease similar to acquired immunodeficiency syndrome (AIDS) in cats, yet in contrast to human immunodeficiency virus (HIV), CD4 is not the viral receptor...
  5. ncbi Virulence differences between two field isolates of feline immunodeficiency virus (FIV-APetaluma and FIV-CPGammar) in young adult specific pathogen free cats
    N C Pedersen
    Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    Vet Immunol Immunopathol 79:53-67. 2001
    The goal of this study was to identify a strain of feline immunodeficiency virus (FIV) that would be more virulent for adult cats than the prototype FIV-APetaluma and, thereby, enhance the FIV infection model for HIV-1 related research...
  6. ncbi Preferential feline immunodeficiency virus (FIV) infection of CD4+ CD25+ T-regulatory cells correlates both with surface expression of CXCR4 and activation of FIV long terminal repeat binding cellular transcriptional factors
    Anjali Joshi
    Immunology Program, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina 27606, USA
    J Virol 79:4965-76. 2005
    ..T-regulatory (Treg) cells with regard to their immune regulatory properties and ability to support feline immunodeficiency virus (FIV) replication in vitro and in vivo...
  7. ncbi OrfA downregulates feline immunodeficiency virus primary receptor CD134 on the host cell surface and is important in viral infection
    Yang Hong
    Department of Immunology and Microbial Science, The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, CA 92037, USA
    J Virol 84:7225-32. 2010
    b>Feline immunodeficiency virus (FIV) OrfA is an accessory protein that is critical for productive viral replication and infection in T cells...
  8. ncbi Vif of feline immunodeficiency virus from domestic cats protects against APOBEC3 restriction factors from many felids
    Jörg Zielonka
    Clinic for Gastroenterology, Hepatology and Infectiology, Heinrich Heine University, Building 23 12 U1 87, Moorenstr 5, 40225 Dusseldorf, Germany
    J Virol 84:7312-24. 2010
    ..more insight into the role of APOBEC3 (A3) cytidine deaminases in the species-specific restriction of feline immunodeficiency virus (FIV) of the domestic cat, we tested the A3 proteins present in big cats (puma, lion, tiger, and lynx)...
  9. ncbi Functional interactions of nucleocapsid protein of feline immunodeficiency virus and cellular prion protein with the viral RNA
    Mila Moscardini
    Department of Biomedicine, University of Pisa, I-56127 Pisa, Italy
    J Mol Biol 318:149-59. 2002
    ..properties of the human prion protein, we set up an in vitro system to investigate replication of the feline immunodeficiency virus (FIV), which is functionally and phylogenetically distant from HIV-1...
  10. ncbi Mapping the encapsidation determinants of feline immunodeficiency virus
    Iris Kemler
    Molecular Medicine Program, Departments of Immunology and Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Virol 76:11889-903. 2002
    ..Feline lentiviral (feline immunodeficiency virus [FIV]) encapsidation has not been studied...
  11. ncbi Structural mapping of CD134 residues critical for interaction with feline immunodeficiency virus
    Aymeric de Parseval
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Nat Struct Mol Biol 12:60-6. 2005
    CD134 is a primary binding receptor for feline immunodeficiency virus (FIV), and with CXCR4 facilitates infection of CD4(+) T cells. Human CD134 fails to support FIV infection...
  12. ncbi Delineation of sequences important for efficient packaging of feline immunodeficiency virus RNA
    Matthew T Browning
    The University of Texas MD Anderson Cancer Center, Department of Veterinary Sciences, Bastrop, TX 78602, USA
    J Gen Virol 84:621-7. 2003
    We have used systematic deletion analysis of the 5' untranslated region (UTR) of the feline immunodeficiency virus (FIV) genome, both in the presence and absence of various amounts of gag, to define the cis-acting sequences responsible ..
  13. ncbi Human gene therapy vectors derived from feline lentiviruses
    Román A Barraza
    Molecular Medicine Program, Guggenheim 18, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, United States
    Vet Immunol Immunopathol 123:23-31. 2008
    Lentiviral vectors are useful for gene transfer to dividing and nondividing cells. Feline immunodeficiency virus (FIV) vectors transduce most human cell types with good efficiency and may have advantages for clinical gene therapy ..
  14. ncbi Genetically divergent strains of feline immunodeficiency virus from the domestic cat (Felis catus) and the African lion (Panthera leo) share usage of CD134 and CXCR4 as entry receptors
    William A McEwan
    Faculty of Veterinary Medicine, Retrovirus Research Laboratory, Institute of Comparative Medicine, University of Glasgow, Bearsden Road, Glasgow, United Kingdom
    J Virol 82:10953-8. 2008
    The env open reading frames of African lion (Panthera leo) lentivirus (feline immunodeficiency virus [FIV(Ple)]) subtypes B and E from geographically distinct regions of Africa suggest two distinct ancestries, with FIV(Ple)-E sharing a ..
  15. ncbi CD134 and CXCR4 expression corresponds to feline immunodeficiency virus infection of lymphocytes, macrophages and dendritic cells
    F Reggeti
    Department of Pathobiology, University of Guelph, Guelph, ON N1G 2W1, Canada
    J Gen Virol 89:277-87. 2008
    The lymphotropic lentiviruses feline immunodeficiency virus (FIV) and human immunodeficiency virus (HIV) enter cells by sequential interaction with primary receptors CD134 or CD4, respectively, and subsequently with chemokine receptors...
  16. ncbi Antiviral activity of membrane fusion inhibitors that target gp40 of the feline immunodeficiency virus envelope protein
    Fuminori Mizukoshi
    Department of Veterinary Internal Medicine, The University of Tokyo, Bunkyo ku, Tokyo 113 8657, Japan
    Vet Microbiol 136:155-9. 2009
    ..to examine the inhibitory effect of modified peptides corresponding to heptad repeats (HR) 1 and 2 of feline immunodeficiency virus (FIV) envelope gp40 on the fusion between the viral and cellular membranes...
  17. ncbi Cytokine response in multiple lymphoid tissues during the primary phase of feline immunodeficiency virus infection
    G A Dean
    Department of Microbiology, Pathology, and Parasitology, North Carolina State University, Raleigh, North Carolina 27606, USA
    J Virol 72:9436-40. 1998
    ..various time periods and in various lymphoid compartments during the acute stage (first 4 months) of feline immunodeficiency virus (FIV) infection in laboratory cats. Cytokine responses were correlated with virus replication...
  18. ncbi Feline immunodeficiency virus neuropathogenesis: from cats to calcium
    Rick B Meeker
    Department of Neurology, University of North Carolina, CB 7025, 6109F Neuroscience Research Bldg, Chapel Hill, NC 27599, USA
    J Neuroimmune Pharmacol 2:154-70. 2007
    ..made from in vitro and in vivo studies on the infectious and pathological interactions of feline immunodeficiency virus (FIV) with the nervous system...
  19. ncbi RNA secondary structure of the feline immunodeficiency virus 5'UTR and Gag coding region
    Laurie James
    CNRS UPR2167 Centre de Génétique Moléculaire, Avenue de la Terrasse, 91190 Gif sur Yvette, France
    Nucleic Acids Res 36:4653-66. 2008
    ..into the structure-function relationship of lentiviral 5'UTRs, we modelled the RNA structure of the feline immunodeficiency virus (FIV), a virus that is evolutionarily distant from the primate viruses...
  20. ncbi Neonatal gene therapy of glycogen storage disease type Ia using a feline immunodeficiency virus-based vector
    Albert Grinshpun
    Goldyne Savad Institute of Gene Therapy, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Mol Ther 18:1592-8. 2010
    ..Vectors have been constructed from feline immunodeficiency virus (FIV), a nonprimate lentivirus, because the wild-type virus does not cause disease in humans...
  21. ncbi In vivo depletion of CD4(+)CD25(hi) regulatory T cells is associated with improved antiviral responses in cats chronically infected with feline immunodeficiency virus
    S Rochelle Mikkelsen
    College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA
    Virology 403:163-72. 2010
    ..Lentivirus-induced CD4(+)CD25(hi) Treg cells were first described in feline immunodeficiency virus (FIV)-infected cats...
  22. ncbi Immunohistochemical localization of feline immunodeficiency virus using native species antibodies
    Arlin B Rogers
    Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, Colorado 80523-1674, USA
    Am J Pathol 161:1143-51. 2002
    b>Feline immunodeficiency virus (FIV) is the feline analog of human immunodeficiency virus and a small animal model of human acquired immune deficiency syndrome (AIDS)...
  23. ncbi Seroprevalence of feline leukemia virus and feline immunodeficiency virus infection among cats in North America and risk factors for seropositivity
    Julie K Levy
    Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 32610-0126, USA
    J Am Vet Med Assoc 228:371-6. 2006
    ..However, cats in all categories were found to be at risk for infection, and current guidelines to test all cats at the time of acquisition and again during illness should be followed...
  24. ncbi Feline immunodeficiency virus infection phenotypically and functionally activates immunosuppressive CD4+CD25+ T regulatory cells
    Thomas W Vahlenkamp
    Immunology Program, North Carolina State University, Raleigh, NC 27606, USA
    J Immunol 172:4752-61. 2004
    Disease progression of feline immunodeficiency virus (FIV) infection is characterized by up-regulation of B7.1 and B7.2 costimulatory molecules and their ligand CTLA4 on CD4(+) and CD8(+) T cells...
  25. ncbi Phylogenetic and genetic analysis of feline immunodeficiency virus gag, pol, and env genes from domestic cats undergoing nucleoside reverse transcriptase inhibitor treatment or treatment-naïve cats in Rio de Janeiro, Brazil
    Angelica N Martins
    Laboratory of Molecular Virology, Department of Genetics, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil
    J Virol 82:7863-74. 2008
    b>Feline immunodeficiency virus (FIV) is the Lentivirus responsible for an immunodeficiency-like disease in domestic cats (Felis catus). FIV is divided into five phylogenetic subtypes (A, B, C, D, and E), based on genetic diversity...
  26. ncbi Mutational analysis of the feline immunodeficiency virus matrix protein
    M L Manrique
    , Serrano 669, C1414DEM, Buenos Aires, Argentina
    Virus Res 76:103-13. 2001
    To study the process of feline immunodeficiency virus (FIV) assembly, we examined the suitability of the vaccinia vector system to reproduce FIV particle formation...
  27. ncbi Molecular subtyping of feline immunodeficiency virus from domestic cats in Australia
    R K C Kann
    School of Veterinary Science, University of Queensland, Queensland
    Aust Vet J 84:112-6. 2006
    OBJECTIVE: To determine the prevalent subtypes of feline immunodeficiency virus (FIV) present in the domestic cat population of Australia...
  28. ncbi Phylogenetic analysis to define feline immunodeficiency virus subtypes in 31 domestic cats in South Africa
    R Kann
    School of Veterinary Science, University of Queensland, St Lucia, Queensland, 4072, Australia
    J S Afr Vet Assoc 77:108-13. 2006
    b>Feline immunodeficiency virus (FIV), a lentivirus, is an important pathogen of domestic cats around the world and has many similarities to human immunodeficiency virus (HIV)...
  29. ncbi A feline immunodeficiency virus vif-deletion mutant remains attenuated upon infection of newborn kittens
    Xiaoying Shen
    Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    J Gen Virol 88:2793-9. 2007
    ..attenuation associated with a vif mutation by inoculation of newborn kittens with a vif-deleted feline immunodeficiency virus provirus plasmid (FIV-pPPRDeltavif)...
  30. ncbi Pre-existing immunity to pathogenic Listeria monocytogenes does not prevent induction of immune responses to feline immunodeficiency virus by a novel recombinant Listeria monocytogenes vaccine
    Rosemary Stevens
    Department of Microbiology, Pathology and Parasitology, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
    Vaccine 23:1479-90. 2005
    ..The FIV/cat model will provide a useful challenge system to determine whether recombinant L. monocytogenes can protect against a lentivirus in its natural host after challenge by the routes common to HIV transmission...
  31. ncbi Modulation of the virus-receptor interaction by mutations in the V5 loop of feline immunodeficiency virus (FIV) following in vivo escape from neutralising antibody
    Brian J Willett
    Retrovirus Research Laboratory, Institute of Comparative Medicine, Faculty of Veterinary Medicine, University of Glasgow, Bearsden Road, Glasgow, UK
    Retrovirology 7:38. 2010
    In the acute phase of infection with feline immunodeficiency virus (FIV), the virus targets activated CD4+ T cells by utilising CD134 (OX40) as a primary attachment receptor and CXCR4 as a co-receptor...
  32. ncbi Intrahost evolution of envelope glycoprotein and OrfA sequences after experimental infection of cats with a molecular clone and a biological isolate of feline immunodeficiency virus
    Willem Huisman
    Erasmus MC, Institute of Virology, Rotterdam, The Netherlands
    Virus Res 137:24-32. 2008
    b>Feline immunodeficiency virus (FIV) is a member of the genus Lentivirus and causes AIDS-like disease in its natural host, the cat...
  33. ncbi Feline immunodeficiency virus (FIV) in wild Pallas' cats
    Meredith A Brown
    Laboratory of Genomic Diversity, National Cancer Institute Frederick, Frederick, MD 21702, USA
    Vet Immunol Immunopathol 134:90-5. 2010
    b>Feline immunodeficiency virus (FIV), a feline lentivirus related to HIV, causes immune dysfunction in domestic and wild cats...
  34. ncbi Phylogenetic analysis of Vietnamese isolates of feline immunodeficiency virus: genetic diversity of subtype C
    K Nakamura
    Department of Veterinary Microbiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan
    Arch Virol 148:783-91. 2003
    Phylogenetic relationships of novel Vietnamese strains of feline immunodeficiency virus (FIV) were analysed...
  35. ncbi High genetic stability of TM1 and TM2 strains of subtype B feline immunodeficiency virus in long-term infection
    Yasuhiro Ikeda
    Department of Veterinary Microbiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Japan
    J Vet Med Sci 66:287-9. 2004
    To know the genetic changes of feline immunodeficiency virus (FIV) in long-term infection in cats, we inoculated three specific pathogen-free cats with FIV isolates and determined a partial env sequence covering the V3-V5 region...
  36. ncbi Feline immunodeficiency virus OrfA is distinct from other lentivirus transactivators
    Udayan Chatterji
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Virol 76:9624-34. 2002
    The feline immunodeficiency virus (FIV) accessory factor, OrfA, facilitates transactivation of transcription directed by elements of the viral long terminal repeat (LTR)...
  37. ncbi Shared usage of the chemokine receptor CXCR4 by the feline and human immunodeficiency viruses
    B J Willett
    Department of Veterinary Pathology, University of Glasgow Veterinary School, United Kingdom
    J Virol 71:6407-15. 1997
    b>Feline immunodeficiency virus (FIV) induces a disease state in the domestic cat that is similar to AIDS in human immunodeficiency virus (HIV)-infected individuals...
  38. ncbi The critical role of proximal gag sequences in feline immunodeficiency virus genome encapsidation
    Iris Kemler
    Molecular Medicine Program, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Virology 327:111-20. 2004
    ..b>Feline immunodeficiency virus (FIV) RNA encapsidation determinants have been shown to be discrete and noncontinuous, comprising one ..
  39. ncbi Feline immunodeficiency virus ORF-Ais required for virus particle formation and virus infectivity
    Malou C Gemeniano
    Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, California 95616, USA
    J Virol 77:8819-30. 2003
    The orf-A (orf-2) gene of feline immunodeficiency virus (FIV) is a small open reading frame predicted to encode a 77-amino-acid protein that contains putative domains similar to those of the ungulate lentiviral Tat protein...
  40. ncbi A dormant internal ribosome entry site controls translation of feline immunodeficiency virus
    Valentina Camerini
    Ecole Normale Superieure de Lyon, Unité de Virologie Humaine, IFR 128, Lyon F 69364, France
    J Virol 82:3574-83. 2008
    ..entry sites (IRESs) in virtually all lentiviruses prompted us to investigate the mechanism used by the feline immunodeficiency virus (FIV) to produce viral proteins...
  41. ncbi Evolution of replication efficiency following infection with a molecularly cloned feline immunodeficiency virus of low virulence
    Margaret J Hosie
    Department of Veterinary Pathology, University of Glasgow, Glasgow G61 1QH, United Kingdom
    J Virol 76:6062-72. 2002
    ..with the domestic cat have demonstrated that vaccinal immunity to infection can be induced against feline immunodeficiency virus (FIV); however, protection is largely restricted to laboratory strains of FIV and does not extend to ..
  42. ncbi Cerebrospinal fluid is an efficient route for establishing brain infection with feline immunodeficiency virus and transfering infectious virus to the periphery
    Pinghuang Liu
    Immunology Program, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, USA
    J Neurovirol 12:294-306. 2006
    Like human immunodeficiency virus (HIV), feline immunodeficiency virus (FIV) invades and infects the central nervous system (CNS) soon after peripheral infection...
  43. ncbi Molecular characterization of feline immunodeficiency virus budding
    Benjamin G Luttge
    Virus Cell Interaction Section, HIV Drug Resistance Program, NCI Frederick, Bldg 535, RM 108, Frederick, MD 21702 1201, USA
    J Virol 82:2106-19. 2008
    Infection of domestic cats with feline immunodeficiency virus (FIV) is an important model system for studying human immunodeficiency virus type 1 (HIV-1) infection due to numerous similarities in pathogenesis induced by these two ..
  44. ncbi The secondary structure of the 5' end of the FIV genome reveals a long-range interaction between R/U5 and gag sequences, and a large, stable stem-loop
    Julia C Kenyon
    Department of Medicine, Addenbrooke s Hospital, University of Cambridge, Cambridge CB2 2QQ, United Kingdom
    RNA 14:2597-608. 2008
    b>Feline immunodeficiency virus (FIV) is a lentivirus that infects cats and is related to human immunodeficiency virus (HIV)...
  45. ncbi Antiviral activity and conformational features of an octapeptide derived from the membrane-proximal ectodomain of the feline immunodeficiency virus transmembrane glycoprotein
    Simone Giannecchini
    Retrovirus Center and Virology Section, Department of Experimental Pathology, University of Pisa, I-56127 Pisa, Italy
    J Virol 77:3724-33. 2003
    b>Feline immunodeficiency virus (FIV) provides a valuable animal model by which criteria for lentivirus control strategies can be tested...
  46. ncbi Nonpathogenic lion and puma lentiviruses impart resistance to superinfection by virulent feline immunodeficiency virus
    Sue Vandewoude
    Department of Pathology, Colorado State University, Fort Collins, Colorado 80523 1671, USA
    J Acquir Immune Defic Syndr 29:1-10. 2002
    ..The feline immunodeficiency virus (FIV) is highly divergent from LLV and PLV and is pathogenic for domestic cats...
  47. ncbi AIDS vaccination studies using an ex vivo feline immunodeficiency virus model: protection from an intraclade challenge administered systemically or mucosally by an attenuated vaccine
    Mauro Pistello
    Retrovirus Center and Virology Section, Department of Experimental Pathology, University of Pisa, Pisa, Italy
    J Virol 77:10740-50. 2003
    b>Feline immunodeficiency virus (FIV) infection of domestic cats represents a valuable system through which to investigate criteria for antilentiviral vaccines in a natural host species...
  48. ncbi Feline immunodeficiency virus env gene evolution in experimentally infected cats
    Martin Kraase
    Retrovirus Research Laboratory, Institute of Comparative Medicine, Faculty of Veterinary Medicine, University of Glasgow, Bearsden Road, Glasgow G61 1QH, United Kingdom
    Vet Immunol Immunopathol 134:96-106. 2010
    b>Feline immunodeficiency virus (FIV), an immunosuppressive lentivirus found in cats worldwide, is studied to illuminate mechanisms of lentiviral pathogenesis and to identify key components of protective immunity...
  49. ncbi Neutralization of feline immunodeficiency virus by antibodies targeting the V5 loop of Env
    Ayman Samman
    Retrovirus Research Laboratory, Institute of Comparative Medicine, Faculty of Veterinary Medicine, University of Glasgow, Bearsden, Glasgow G61 1QH, UK
    J Gen Virol 91:242-9. 2010
    Neutralizing antibodies (NAbs) play a vital role in vaccine-induced protection against infection with feline immunodeficiency virus (FIV)...
  50. ncbi Bold attitude makes male urban feral domestic cats more vulnerable to Feline Immunodeficiency Virus
    Eugenia Natoli
    Azienda USL Roma D, Area Dipartimentale Sanita Pubblica veterinaria, Ospedale Veterinario, via della Magliana 856, 00148 Roma, Italy
    Neurosci Biobehav Rev 29:151-7. 2005
    ..a high annual reproductive success but, on the other hand, to a high probability to be infected by the Feline Immunodeficiency Virus (FIV), a lethal disease caused by a retrovirus...
  51. ncbi A single site for N-linked glycosylation in the envelope glycoprotein of feline immunodeficiency virus modulates the virus-receptor interaction
    Brian J Willett
    Retrovirus Research Laboratory, Institute of Comparative Medicine, Faculty of Veterinary Medicine, University of Glasgow, Bearsden Road, Glasgow, G61 1QH, UK
    Retrovirology 5:77. 2008
    b>Feline immunodeficiency virus (FIV) targets helper T cells by attachment of the envelope glycoprotein (Env) to CD134, a subsequent interaction with CXCR4 then facilitating the process of viral entry...
  52. ncbi Prevention of immunodeficiency virus induced CD4+ T-cell depletion by prior infection with a non-pathogenic virus
    Julie A Terwee
    Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado, USA
    Virology 377:63-70. 2008
    ..These data provide support for the importance of non-adaptive enhancement of the immune response in the prevention of CD4+ T-cell loss...
  53. ncbi Generation of infectious feline immunodeficiency virus (FIV) encoding FIV/human immunodeficiency virus chimeric protease
    Ying Chuan Lin
    Department of Immunology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Virol 84:6799-809. 2010
    b>Feline immunodeficiency virus (FIV) and human immunodeficiency virus type 1 (HIV-1) proteases (PRs) share only 23% amino acid identity and exhibit distinct specificities yet have very similar 3-dimensional structures...
  54. ncbi Ocelots on Barro Colorado Island are infected with feline immunodeficiency virus but not other common feline and canine viruses
    Samuel P Franklin
    Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, Colorado 80523, USA
    J Wildl Dis 44:760-5. 2008
    ..feline calicivirus, feline corona virus, feline panleukopenia virus, canine distemper virus, and feline immunodeficiency virus (FIV), typically a species-specific infection...
  55. ncbi Early pathogenesis of transmucosal feline immunodeficiency virus infection
    Leslie A Obert
    Department of Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado 80523, USA
    J Virol 76:6311-22. 2002
    To identify the early target cells and tissues in transmucosal feline immunodeficiency virus (FIV) infection, cats were exposed to a clade C FIV isolate via the oral-nasal or vaginal mucosa and multiple tissues were examined by virus ..
  56. ncbi Quality of different in-clinic test systems for feline immunodeficiency virus and feline leukaemia virus infection
    Katrin Hartmann
    Clinic for Small Animal Medicine, Ludwig Maximilian University Munich, Veterinaerstrasse 13, 80539 Munich, Germany
    J Feline Med Surg 9:439-45. 2007
    Many new diagnostic in-house tests for identification of feline immunodeficiency virus (FIV) and feline leukaemia virus (FeLV) infection have been licensed for use in veterinary practice, and the question of the relative merits of these ..
  57. ncbi Antibodies specific for hypervariable regions 3 to 5 of the feline immunodeficiency virus envelope glycoprotein are not solely responsible for vaccine-induced acceleration of challenge infection in cats
    Willem Huisman
    Erasmus MC, Institute of Virology, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    J Gen Virol 85:1833-41. 2004
    In a previous vaccination study in cats, the authors reported on accelerated feline immunodeficiency virus (FIV) replication upon challenge in animals vaccinated with a candidate envelope subunit vaccine...
  58. ncbi Envelope gene-mediated neurovirulence in feline immunodeficiency virus infection: induction of matrix metalloproteinases and neuronal injury
    J B Johnston
    Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada
    J Virol 76:2622-33. 2002
    ..contribute to the development of neurological disease following infection by lentiviruses, including feline immunodeficiency virus (FIV)...
  59. ncbi Vaccination with an inactivated virulent feline immunodeficiency virus engineered to express high levels of Env
    Margaret J Hosie
    Retrovirus Research Laboratory, Institute of Comparative Medicine, University of Glasgow, Bearsden Rd, Glasgow G61 1QH, United Kingdom
    J Virol 79:1954-7. 2005
    An inactivated virus vaccine was prepared from a pathogenic isolate of feline immunodeficiency virus containing a mutation that eliminated an endocytic sorting signal in the envelope glycoprotein, increasing its expression on virions...
  60. ncbi Evolution of two amino acid positions governing broad neutralization resistance in a strain of feline immunodeficiency virus over 7 years of persistence in cats
    Mauro Pistello
    Retrovirus Center and Virology Section, Department of Experimental Pathology, University of Pisa, Pisa, Italy
    Clin Diagn Lab Immunol 10:1109-16. 2003
    ..investigating the changes that occurred in a neutralization-sensitive tissue culture-adapted strain of feline immunodeficiency virus after it was reinoculated into cats, a previous study had identified two amino acid positions of the ..
  61. ncbi Downmodulation of CD3epsilon expression in CD8alpha+beta- T cells of feline immunodeficiency virus-infected cats
    Yorihiro Nishimura
    Department of Veterinary Microbiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan
    J Gen Virol 85:2585-9. 2004
    b>Feline immunodeficiency virus (FIV) infection in cats is associated with an increase of feline CD (fCD)8alpha+beta- and fCD8alpha+beta low cells in peripheral blood...
  62. ncbi First molecular characterization of feline immunodeficiency virus in Turkey
    Tuba Cigdem Oguzoglu
    Department of Virology, Ankara University, Turkey
    Arch Virol 155:1877-81. 2010
    In this study, strains of feline immunodeficiency virus (FIV), designated TR-D, TR-Mo and TR-Mi, isolated from three cats in Turkey, were characterized...
  63. ncbi Feline immunodeficiency virus subtypes in domestic cats in New Zealand
    R K C Kann
    N Z Vet J 55:358-60. 2007
  64. ncbi Feline immunodeficiency virus dendritic cell infection and transfer
    WENDY S SPRAGUE
    Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523 1619, USA
    J Gen Virol 89:709-15. 2008
    b>Feline immunodeficiency virus (FIV) interacts with dendritic cells (DC) during initiation of infection, but whether DC support or transfer FIV infection remains unclear...
  65. ncbi Roles of the auxiliary genes and AP-1 binding site in the long terminal repeat of feline immunodeficiency virus in the early stage of infection in cats
    Y Inoshima
    Department of Veterinary Microbiology, Faculty of Agriculture, The University of Tokyo, Bunkyo ku, Japan
    J Virol 70:8518-26. 1996
    To examine the roles of auxiliary genes and the AP-1 binding site in the long terminal repeat of feline immunodeficiency virus (FIV) in vivo, three mutant viruses, which are defective in the vif gene ([delta]vif), ORF-A gene (deltaORF-A),..
  66. ncbi Evaluation of ISCOM-adjuvanted subunit vaccines containing recombinant feline immunodeficiency virus Rev, OrfA and envelope protein in cats
    Willem Huisman
    Erasmus MC, Institute of Virology, Rotterdam, The Netherlands
    Vaccine 26:2553-61. 2008
    For the development of feline immunodeficiency virus (FIV) vaccines mostly structural proteins have been evaluated for their capacity to induce protective immunity...
  67. ncbi Epidemiology of feline foamy virus and feline immunodeficiency virus infections in domestic and feral cats: a seroepidemiological study
    I G Winkler
    School of Pharmacy and Medical Science, University of South Australia, City East, North Terrace, Adelaide, South Australia, 5000, Australia
    J Clin Microbiol 37:2848-51. 1999
    ..A database of the feline foamy virus (FeFV) and feline immunodeficiency virus (FIV) antibody status, age, and sex of 389 domestic cats presented to veterinarians was assembled...
  68. ncbi Recombination in feline immunodeficiency virus from feral and companion domestic cats
    Jessica J Hayward
    Bioinformatics Institute, Allan Wilson Centre for Molecular Ecology and Evolution, School of Biological Sciences, The University of Auckland, Auckland, New Zealand
    Virol J 5:76. 2008
    Recombination is a relatively common phenomenon in retroviruses. We investigated recombination in Feline Immunodeficiency Virus from naturally-infected New Zealand domestic cats (Felis catus) by sequencing regions of the gag, pol and env ..
  69. ncbi Genetic heterogeneity of env gene of feline immunodeficiency virus obtained from multiple districts in Japan
    Y Nishimura
    Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Japan
    Virus Res 57:101-12. 1998
    b>Feline immunodeficiency virus (FIV) infection is widespread in many countries. FIV isolates have been classified into five distinct subtypes, A, B, C, D and E based on their env gene sequences...
  70. ncbi Chimeric human immunodeficiency virus type 1 and feline immunodeficiency virus reverse transcriptases: role of the subunits in resistance/sensitivity to non-nucleoside reverse transcriptase inhibitors
    Joeri Auwerx
    Rega Institute for Medical Research, Katholieke Universiteit Leuven, Leuven, Belgium
    Mol Pharmacol 61:400-6. 2002
    ..acids lining the NNRTI-specific pocket of HIV-1 RT display higher similarity to the corresponding feline immunodeficiency virus (FIV) RT amino acids than to HIV-2 RT, the susceptibility of FIV RT and chimeric HIV-1/FIV RTs to ..
  71. ncbi DNA vaccination affords significant protection against feline immunodeficiency virus infection without inducing detectable antiviral antibodies
    M J Hosie
    Retrovirus Research Laboratory, Department of Veterinary Pathology, University of Glasgow, Bearsden, Glasgow G61 1QH, United Kingdom
    J Virol 72:7310-9. 1998
    ..of a multigene DNA vaccine against lentivirus infection, we generated a defective mutant provirus of feline immunodeficiency virus (FIV) with an in-frame deletion in pol (FIVDeltaRT)...
  72. ncbi Effect of dual-subtype vaccine against feline immunodeficiency virus infection
    T Hohdatsu
    Department of Veterinary Infectious Diseases, School of Veterinary Medicine and Animal Sciences, Kitasato University, Aomori, Japan
    Vet Microbiol 58:155-65. 1997
    Dual-subtype feline immunodeficiency virus (FIV) vaccine, consisting of inactivated cells infected with subtypes A (Petaluma strain) and D (Shizuoka strain), was developed and tested for its vaccine efficacy against FIV infection in ..
  73. ncbi Maternal hematological and virological characteristics during early feline immunodeficiency virus (FIV) infection of cats as predictors of fetal infection and reproductive outcome at early gestation
    Crystal E Boudreaux
    Department of Biological Sciences, Mississippi State University, Mississippi State, MS 39762, USA
    Vet Immunol Immunopathol 131:290-7. 2009
    ..However, maternal virological and hematological characteristics did not correlate either positively or negatively with reproductive outcome...
  74. ncbi Characterization of monocyte-derived dendritic cells from cats infected with feline immunodeficiency virus
    Fuminori Mizukoshi
    Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan
    J Vet Med Sci 71:865-71. 2009
    ..To develop a DC-based immunotherapy for feline immunodeficiency virus (FIV) infection, we carried out a study to characterize DCs from FIV-infected cats and compared the ..
  75. ncbi An updated nation-wide epidemiological survey of feline immunodeficiency virus (FIV) infection in Japan
    Yuki Nakamura
    Laboratory of Veterinary Internal Medicine, Faculty of Agriculture, Kagoshima University, Kagoshima, Japan
    J Vet Med Sci 72:1051-6. 2010
    An updated nation-wide epidemiological survey of feline immunodeficiency virus (FIV) infection was conducted in Japan. Blood samples were collected from 1,770 outdoor accessing cats from March to October 2008. Serologically, 410 cats (23...
  76. ncbi Risk analysis of feline immunodeficiency virus infection in Tsushima leopard cats (Prionailurus bengalensis euptilurus) and domestic cats using a geographic information system
    Shin ichi Hayama
    Laboratory of Wildlife Medicine, Department of Veterinary Science, Nippon Veterinary and Life Science University, Musashino, Tokyo, Japan
    J Vet Med Sci 72:1113-8. 2010
    ..All FIV-positive leopard cats were found in the identified high FIV infection risk areas...
  77. ncbi Domain- and nucleotide-specific Rev response element regulation of feline immunodeficiency virus production
    Hong Na
    Department of Medicine, University of Alberta, Edmonton, AB, Canada T6G 2S2
    Virology 404:246-60. 2010
    Computational analysis of feline immunodeficiency virus (FIV) RNA sequences indicated that common FIV strains contain a rev response element (RRE) defined by a long unbranched hairpin with 6 stem-loop sub-domains, termed stem-loop A (SLA)..
  78. ncbi AIDS vaccination studies using an ex vivo feline immunodeficiency virus model: reevaluation of neutralizing antibody levels elicited by a protective and a nonprotective vaccine after removal of antisubstrate cell antibodies
    S Giannecchini
    Department of Biomedicine and Retrovirus Center, University of Pisa, Pisa, Italy
    J Virol 75:4424-9. 2001
    In the feline immunodeficiency virus system, immunization with a fixed-infected-cell vaccine conferred protection against virulent homologous challenge but the immune effectors involved remained elusive...
  79. ncbi Seroprevalence of Dirofilaria immitis, feline leukemia virus, and feline immunodeficiency virus infection among dogs and cats exported from the 2005 Gulf Coast hurricane disaster area
    Julie K Levy
    Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 32610 0126, USA
    J Am Vet Med Assoc 231:218-25. 2007
    ..To determine seroprevalence of dirofilariasis in dogs and seroprevalences of dirofilariasis, FeLV infection, and FIV infection in cats exported from the Gulf Coast region following the 2005 hurricanes...
  80. ncbi In vitro assembly of feline immunodeficiency virus capsid protein: biological role of conserved cysteines
    M D Nath
    National Cancer Institute, NIH, Frederick, Maryland 21702, USA
    Arch Biochem Biophys 392:287-94. 2001
    ..this report, we have shown that the assembly process is driven by recombinant capsid protein (p26) of feline immunodeficiency virus itself...
  81. ncbi Targeted lymph node immunization can protect cats from a mucosal challenge with feline immunodeficiency virus
    S Finerty
    Department of Clinical Veterinary Science, University of Bristol, Langford, BS40 5DU, Bristol, UK
    Vaccine 20:49-58. 2001
    ..the present study is to determine whether protective immune responses against a mucosal challenge by feline immunodeficiency virus (FIV) can be elicited by targeting the immunization to the medial iliac lymph nodes--the principal ..
  82. ncbi Importance of the short cytoplasmic domain of the feline immunodeficiency virus transmembrane glycoprotein for fusion activity and envelope glycoprotein incorporation into virions
    Cristina C P Celma
    Laboratorio de Virologia, Facultad de Ciencias Exactas y Naturales, Universidad de Belgrano UB, Villanueva 1324 C1426BMJ, Buenos Aires, Argentina
    Virology 366:405-14. 2007
    ..b>Feline immunodeficiency virus (FIV) possesses a TM glycoprotein with a cytoplasmic tail of approximately 53 amino acids which is ..
  83. ncbi A novel interaction of tRNA(Lys,3) with the feline immunodeficiency virus RNA genome governs initiation of minus strand DNA synthesis
    J T Miller
    HIV Drug Resistance Program, NCI-Frederick Cancer Research and Development Center, Frederick, Maryland 21702, USA
    J Biol Chem 276:27721-30. 2001
    Complementarity between nucleotides at the 5' terminus of tRNA(Lys,3) and the U5-IR loop of the feline immunodeficiency virus RNA genome suggests a novel intermolecular interaction controls initiation of minus strand synthesis in a ..
  84. ncbi Evaluation of a novel nested PCR for the routine diagnosis of feline leukemia virus (FeLV) and feline immunodeficiency virus (FIV)
    Alvaro Arjona
    Departamento de Sanidad Animal, Facultad de Veterinaria, Universidad Complutense, 28040 Madrid, Spain
    J Feline Med Surg 9:14-22. 2007
    Laboratory diagnosis of feline leukemia virus (FeLV) and feline immunodeficiency virus (FIV) usually involves both viruses, as the clinical signs are similar and coinfection may occur...
  85. ncbi Feline immunodeficiency virus infection is enhanced by feline bone marrow-derived dendritic cells
    F J U M van der Meer
    Department of Immunology and Infectious Diseases, Division of Virology, Faculty of Veterinary Medicine, Utrecht University, 3584 CL Utrecht, The Netherlands
    J Gen Virol 88:251-8. 2007
    In the pathogenesis of feline immunodeficiency virus (FIV) infection, feline dendritic cells (feDCs) are thought to play an important role...
  86. ncbi Oral immunization with recombinant listeria monocytogenes controls virus load after vaginal challenge with feline immunodeficiency virus
    Rosemary Stevens
    Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA
    J Virol 78:8210-8. 2004
    ..Using the feline immunodeficiency virus (FIV) model of HIV we evaluated recombinant L. monocytogenes in a challenge system...
  87. ncbi Lessons from the cat: development of vaccines against lentiviruses
    Stephen P Dunham
    Retrovirus Research Laboratory, Institute of Comparative Medicine, Faculty of Veterinary Medicine, University of Glasgow, Bearsden Road, Glasgow G61 1QH, United Kingdom
    Vet Immunol Immunopathol 112:67-77. 2006
    b>Feline immunodeficiency virus (FIV) is a natural infection of domestic cats, which produces a disease with many similarities to human immunodeficiency virus (HIV) infection in man...
  88. ncbi Vaccine protection against feline immunodeficiency virus: setting the challenge
    M J Hosie
    Retrovirus Research Laboratory, Institute for Comparative Medicine, Faculty of Veterinary Medicine, The University of Glasgow
    Aust Vet J 85:5-12; quiz 85. 2007
    Since feline immunodeficiency virus (FIV) was first isolated, international research efforts have been directed towards developing a protective vaccine, not least because it may provide a model for a candidate human immunodeficiency ..
  89. ncbi Dual-subtype vaccine (Fel-O-Vax FIV) protects cats against contact challenge with heterologous subtype B FIV infected cats
    Hajime Kusuhara
    Department of Veterinary Infectious Disease, School of Veterinary Medicine and Animal Science, Kitasato University, Towada, Aomori 034-8628, Japan
    Vet Microbiol 108:155-65. 2005
    ..These findings confirmed the efficacy of this vaccine against heterologous stains classified as subtype B, and suggested that the vaccine exhibits broad efficacy against genetically diverse FIV...
  90. ncbi Dissection of seroreactivity against the tryptophan-rich motif of the feline immunodeficiency virus transmembrane glycoprotein
    Giulia Freer
    Department of Experimental Pathology, University of Pisa, I-56127 Pisa, Italy
    Virology 322:360-9. 2004
    ..motif (TrpM) in the membrane-proximal ectodomain of the transmembrane (TM) glycoprotein of feline immunodeficiency virus (FIV) was investigated...
  91. ncbi Phylogenetic analysis of feline immunodeficiency virus in Central Europe: a prerequisite for vaccination and molecular diagnostics
    Adolf Steinrigl
    Institute of Virology, University of Veterinary Medicine, , A-1210 Vienna, Austria
    J Gen Virol 84:1301-7. 2003
    b>Feline immunodeficiency virus (FIV) is a worldwide-occurring lentivirus that severely impairs the immune function of infected domestic cats...
  92. ncbi Prime-boost vaccination using DNA and whole inactivated virus vaccines provides limited protection against virulent feline immunodeficiency virus
    Stephen P Dunham
    Retrovirus Research Laboratory, Institute of Comparative Medicine, Faculty of Veterinary Medicine, University of Glasgow, Bearsden Road, Glasgow G61 1QH, United Kingdom
    Vaccine 24:7095-108. 2006
    Protection against feline immunodeficiency virus (FIV) has been achieved using a variety of vaccines notably whole inactivated virus (WIV) and DNA...
  93. ncbi Vaccination of cats with attenuated feline immunodeficiency virus proviral DNA vaccine expressing gamma interferon
    Soumi Gupta
    Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    J Virol 81:465-73. 2007
    A feline immunodeficiency virus (FIV) provirus with a vif gene deletion (FIVDelta vifATGgamma) that coexpresses feline gamma interferon (IFN-gamma) was tested as a proviral DNA vaccine to extend previous studies showing efficacy with an ..
  94. ncbi Feline immunodeficiency virus: a concise review
    Luis Isamu Barros Kanzaki
    Federal University of Amapa, Departament of Microbiology, Rodovia Juscelino Kubtscheck de Oliveira, Km 02. Macapa, Amapa, Brasil
    Front Biosci 9:370-7. 2004
    Among non-primate vertebrates, feline immunodeficiency virus (FIV) infection in the cat may be the closest model of human immunodeficiency virus (HIV) infection and acquired immunodeficiency syndrome (AIDS)...
  95. ncbi New challenges for the diagnosis of feline immunodeficiency virus infection
    P Cynda Crawford
    Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, 2015 SW 16th Avenue, Gainesville, FL 32610, USA
    Vet Clin North Am Small Anim Pract 37:335-50, vii. 2007
    Vaccination of cats against feline immunodeficiency virus (FIV) with a whole-virus vaccine results in rapid and persistent production of antibodies that are indistinguishable from those used for diagnosis of FIV infection...
  96. ncbi Limited efficacy of an inactivated feline immunodeficiency virus vaccine
    S P Dunham
    Institute of Comparative Medicine, Faculty of Veterinary Medicine, University of Glasgow, Bearsden Road, Glasgow G61 1QH
    Vet Rec 158:561-2. 2006
  97. ncbi FeLV and FIV in a cat population
    Richard Brown
    Vet Rec 161:396. 2007
  98. ncbi Placental immunopathology and pregnancy failure in the FIV-infected cat
    C C Weaver
    Department of Biological Sciences, Mississippi State University, Mississippi State, MS, USA
    Placenta 26:138-47. 2005
    ..The feline immunodeficiency virus (FIV)-infected cat is a model for HIV infections due to similarities in biology and clinical disease...
  99. ncbi Lentivirus-specific cytotoxic T-lymphocyte responses are rapidly lost in thymectomized cats infected with feline immunodeficiency virus
    Kathleen A Hayes
    Department of Veterinary Biosciences, Center for Retrovirus Research, The Ohio State University, 1925 Coffey Road, Columbus, Ohio 43210, USA
    J Virol 79:8237-42. 2005
    ..ThX and mock-ThX cats were inoculated with feline immunodeficiency virus (FIV) and monitored for their FIV-specific CTL responses...
  100. ncbi Feline immunodeficiency virus diagnosis after vaccination
    Philip R Andersen
    IDEXX Laboratories Inc, One IDEXX Drive, Westbrook, ME 04092, USA
    Anim Health Res Rev 5:327-30. 2004
    Prior to the widespread use of vaccination for the control of feline immunodeficiency virus (FIV) infection, diagnosis was made by the detection of antibodies against FIV...
  101. ncbi Expression of CD134 and CXCR4 mRNA in term placentas from FIV-infected and control cats
    Veronica L Scott
    Department of Biological Sciences, Mississippi State University, P O Box GY, Mississippi State, Mississippi 39762, United States
    Vet Immunol Immunopathol 123:90-6. 2008
    b>Feline immunodeficiency virus (FIV) causes a natural infection of domestic cats that resembles HIV-1 in pathogenesis and disease progression...

Research Grants88

  1. Stampidine: A Novel Broad-Spectrum Antiviral Agent
    Taracad Venkatachalam; Fiscal Year: 2003
    ..We are now proposing studies aimed at evaluating the safety and efficacy of STAMP against the feline immunodeficiency virus (FIV) infection in domestic cats, an established model for HIV-1 infection in man...
  2. PERIPHERAL NEUROPATHY IN LENTIVIRUS INFECTIONS: EARLY VIRAL AND HOST DETERMINANTS
    Christopher Power; Fiscal Year: 2010
    ..Lentiviruses including HIV-1 and feline immunodeficiency virus (FIV) cause immunosuppression and neurological disease defined by the development of DSP...
  3. Stampidine: A Novel Broad-Spectrum Anti-HIV Microbicide
    OSMOND D CRUZ; Fiscal Year: 2005
    ..of STAMP >4-logs higher than its IC50 value and exhibited potent antiretroviral activity in feline immunodeficiency virus (FlV)-infected cats...
  4. Molecular Analysis of FIV
    John Elder; Fiscal Year: 2007
    The proposed research is for continuation of studies to characterize the feline immunodeficiency virus (FIV) genome, to define mechanisms of entry into target cells and details of the virus life cycle...
  5. Evaluation of thymus function in lentivirus disease
    Lawrence Mathes; Fiscal Year: 2005
    ..b>Feline immunodeficiency virus (FIV) infection of cats leads to significant pathological changes in the thymus with many similar ..
  6. Evaluation of thymus function in lentivirus disease
    Lawrence Mathes; Fiscal Year: 2009
    ..b>Feline immunodeficiency virus (FIV) infection of cats leads to significant pathological changes in the thymus with many similar ..
  7. Vanadocenes as a New Class of Spermicidal Drugs
    OSMOND D CRUZ; Fiscal Year: 2007
    ..VDDTC significantly enhanced the microbicide efficacy of the antiretroviral spermicide WHI- 07 in the feline immunodeficiency virus/cat model of AIDS...
  8. Choroid plexus macrophages in FIV neuropathogenesis
    RICK MEEKER; Fiscal Year: 2009
    ..b>Feline immunodeficiency virus (FIV) offers an alternative model of lentiviral neuropathogenesis which recapitulates all essential ..
  9. Choroid plexus macrophages in FIV neuropathogenesis
    RICK MEEKER; Fiscal Year: 2007
    ..b>Feline immunodeficiency virus (FIV) offers an alternative model of lentiviral neuropathogenesis which recapitulates all essential ..
  10. Lentiviral Genome Processing
    Eric Poeschla; Fiscal Year: 2007
    ..The laboratory studies HIV-1 and feline immunodeficiency virus (FIV)...
  11. Mechanisms of Feline Lentivirus Control and Interference
    Sue Vandewoude; Fiscal Year: 2009
    ..avirulent infection, and have determined that such infection attenuates subsequent virulent feline immunodeficiency virus (FIV) challenge...
  12. Mechanisms of Feline Lentivirus Control and Interference
    Sue Vandewoude; Fiscal Year: 2009
    ..avirulent infection, and have determined that such infection attenuates subsequent virulent feline immunodeficiency virus (FIV) challenge...
  13. Mechanisms of Feline Lentivirus Control and Interference
    Sue Vandewoude; Fiscal Year: 2010
    ..avirulent infection, and have determined that such infection attenuates subsequent virulent feline immunodeficiency virus (FIV) challenge...
  14. Characterization of cell clones resistant to HIV
    Richard Sutton; Fiscal Year: 2007
    ..leucosis virus, human foamy virus, bovine immunodeficiency virus, equine infectious anemia virus, feline immunodeficiency virus, and SIV...
  15. Feline Immunodeficiency Virus Orf-A a Model for HIV Vpr
    Ellen Sparger; Fiscal Year: 2007
    The feline immunodeficiency virus (FIV) animal model presents a unique and significant opportunity for assessing novel antiviral strategies for HIV/AIDS in humans...
  16. SIV delta vif DNA Vaccines with Cytokine Adjuvants
    Ellen Sparger; Fiscal Year: 2004
    ..We have been investigating live-attenuated feline immunodeficiency virus (FIV) vaccines for inducing protective immunity in cats (Preliminary Results)...
  17. Enhancing hepatocyte gene transfer for Hemophilia A
    Paul McCray; Fiscal Year: 2007
    ..Towards this end, we are using a lentiviral vector based on the non-primate feline immunodeficiency virus (FIV) expressing the human FVIII (FVIII) cDNA to correct the phenotype in a mouse model of the ..
  18. Functional Analysis of FIV ORF-A
    Ayalew Mergia; Fiscal Year: 2004
    DESCRIPTION (provided by applicant):Feline immunodeficiency virus (FIV), a lentivirus of cats, causes an AIDS similar to what is seen in humans with human immunodeficiency virus (HIV)...