avian leukosis virus

Summary

Summary: The type species of ALPHARETROVIRUS producing latent or manifest lymphoid leukosis in fowl.

Top Publications

  1. ncbi A low incidence of histiocytic sarcomatosis associated with infection of chickens with the HPRS-103 strain of subgroup J avian leukosis virus
    S S Arshad
    Institute for Animal Health, Newbury, Berkshire, England
    Avian Dis 41:947-56. 1997
  2. ncbi Tumors associated with avian leukosis virus subgroup J in layer hens during 2007 to 2009 in China
    Ziqiang Cheng
    College of Animal Science and Veterinary Medicine, Shandong Agricultural University, Tai an, PR China
    J Vet Med Sci 72:1027-33. 2010
  3. pmc Complete association between a retroviral insertion in the tyrosinase gene and the recessive white mutation in chickens
    Chung Ming Chang
    UMR Génétique et Diversité Animales, INRA INA P G, Centre de Recherches de Jouy, 78352 Jouy en Josas, France
    BMC Genomics 7:19. 2006
  4. pmc Molecular epidemiology of avian leukosis virus subgroup J in layer flocks in China
    Yulong Gao
    Division of Avian Infectious Diseases, State corrected Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China
    J Clin Microbiol 50:953-60. 2012
  5. pmc Identification of a cellular receptor for subgroup E avian leukosis virus
    H B Adkins
    Department of Microbiology and Molecular Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 94:11617-22. 1997
  6. doi Isolation and characterization of emerging subgroup J avian leukosis virus associated with hemangioma in egg-type chickens
    Hanzhang Lai
    College of Veterinary Medicine, South China Agricultural University, 483 Wushan Street, Tianhe District, Guangzhou, Guangdong Province 510642, People s Republic of China
    Vet Microbiol 151:275-83. 2011
  7. ncbi Cellular uptake of avian leukosis virus subgroup B is mediated by clathrin
    Felipe Diaz-Griffero
    Skirball Institute of Biomolecular Medicine, New York University School of Medicine, NY 10003, USA
    Virology 337:45-54. 2005
  8. ncbi Detection of Avian leukosis virus genome by a nested polymerase chain reaction using DNA and RNA from dried feather shafts
    Hitoshi Hatai
    Laboratory of Comparative Pathology, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060 0818, Japan
    J Vet Diagn Invest 21:519-22. 2009
  9. doi Simultaneous endemic infections with subgroup J avian leukosis virus and reticuloendotheliosis virus in commercial and local breeds of chickens
    Zhizhong Cui
    College of Veterinary Medicine, Shandong Agricultural University, Taian, China
    Avian Pathol 38:443-8. 2009
  10. ncbi Development of a polymerase chain reaction to differentiate avian leukosis virus (ALV) subgroups: detection of an ALV contaminant in commercial Marek's disease vaccines
    Robert F Silva
    USDA, Agricultural Research Service, Avian Disease and Oncology Laboratory, 3606 E Mount Hope Road, East Lansing, MI 48823, USA
    Avian Dis 51:663-7. 2007

Detail Information

Publications167 found, 100 shown here

  1. ncbi A low incidence of histiocytic sarcomatosis associated with infection of chickens with the HPRS-103 strain of subgroup J avian leukosis virus
    S S Arshad
    Institute for Animal Health, Newbury, Berkshire, England
    Avian Dis 41:947-56. 1997
    ..proliferative lesions in meat-type chickens associated in low incidence with infection by subgroup J avian leukosis virus (ALV) are described...
  2. ncbi Tumors associated with avian leukosis virus subgroup J in layer hens during 2007 to 2009 in China
    Ziqiang Cheng
    College of Animal Science and Veterinary Medicine, Shandong Agricultural University, Tai an, PR China
    J Vet Med Sci 72:1027-33. 2010
    ..the 3 years leading up to November 2009, 6 different types of naturally occurring neoplasms associated with avian leukosis virus subgroup J (ALV-J) were diagnosed by histopathology, polymerase chain reaction (PCR) and ..
  3. pmc Complete association between a retroviral insertion in the tyrosinase gene and the recessive white mutation in chickens
    Chung Ming Chang
    UMR Génétique et Diversité Animales, INRA INA P G, Centre de Recherches de Jouy, 78352 Jouy en Josas, France
    BMC Genomics 7:19. 2006
    ..The albino mutation was found to be a 6 bp deletion in the tyrosinase (TYR) gene. The present work describes an approach to identify the structural rearrangement in the TYR gene associated with the recessive white mutation...
  4. pmc Molecular epidemiology of avian leukosis virus subgroup J in layer flocks in China
    Yulong Gao
    Division of Avian Infectious Diseases, State corrected Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China
    J Clin Microbiol 50:953-60. 2012
    b>Avian leukosis virus subgroup J (ALV-J) was first isolated from meat-type chickens in 1988. No field cases of ALV-J infection or tumors in layer chickens were observed worldwide until 2004...
  5. pmc Identification of a cellular receptor for subgroup E avian leukosis virus
    H B Adkins
    Department of Microbiology and Molecular Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 94:11617-22. 1997
    Genetic studies in chickens and receptor interference experiments have indicated that avian leukosis virus (ALV)-E may utilize a cellular receptor related to the receptor for ALV-B and ALV-D...
  6. doi Isolation and characterization of emerging subgroup J avian leukosis virus associated with hemangioma in egg-type chickens
    Hanzhang Lai
    College of Veterinary Medicine, South China Agricultural University, 483 Wushan Street, Tianhe District, Guangzhou, Guangdong Province 510642, People s Republic of China
    Vet Microbiol 151:275-83. 2011
    Subgroup J avian leukosis virus (ALV-J), first isolated in 1989, predominantly causes myeloid leukosis (ML) in meat-type or egg-type chicken...
  7. ncbi Cellular uptake of avian leukosis virus subgroup B is mediated by clathrin
    Felipe Diaz-Griffero
    Skirball Institute of Biomolecular Medicine, New York University School of Medicine, NY 10003, USA
    Virology 337:45-54. 2005
    b>Avian leukosis virus (ALV) requires endocytosis and a low pH step for successful viral entry...
  8. ncbi Detection of Avian leukosis virus genome by a nested polymerase chain reaction using DNA and RNA from dried feather shafts
    Hitoshi Hatai
    Laboratory of Comparative Pathology, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060 0818, Japan
    J Vet Diagn Invest 21:519-22. 2009
    ..using frozen feather pulp is useful for detecting fowl glioma-inducing virus (FGV), which belongs to the Avian leukosis virus family, and it has recently been suggested that FGV has spread to ornamental chickens kept in Japanese ..
  9. doi Simultaneous endemic infections with subgroup J avian leukosis virus and reticuloendotheliosis virus in commercial and local breeds of chickens
    Zhizhong Cui
    College of Veterinary Medicine, Shandong Agricultural University, Taian, China
    Avian Pathol 38:443-8. 2009
    Epidemiological studies of subgroup J avian leukosis virus (ALV-J) and reticuloendotheliosis virus (REV) infections were conducted during 1999 to 2009 on 29 chicken flocks of various commercial and local breeds located in six provinces in ..
  10. ncbi Development of a polymerase chain reaction to differentiate avian leukosis virus (ALV) subgroups: detection of an ALV contaminant in commercial Marek's disease vaccines
    Robert F Silva
    USDA, Agricultural Research Service, Avian Disease and Oncology Laboratory, 3606 E Mount Hope Road, East Lansing, MI 48823, USA
    Avian Dis 51:663-7. 2007
    ..The LTR was found to be similar to those LTRs found in endogenous ALVs (subgroup E) and very dissimilar to LTRs normally found in subgroup A viruses. The E-like LTR probably explains why the contaminant grew so poorly in cell culture...
  11. pmc The avian retrovirus avian sarcoma/leukosis virus subtype A reaches the lipid mixing stage of fusion at neutral pH
    Laurie J Earp
    Department of Microbiology, University of Virginia, Charlottesville, Virginia 22908, USA
    J Virol 77:3058-66. 2003
    ..Possible roles for low pH at subsequent stages of viral entry are discussed...
  12. pmc Development of a loop-mediated isothermal amplification assay for rapid detection of subgroup J avian leukosis virus
    Xiaotao Zhang
    Key Laboratory of Animal Disease Control and Prevention of the Ministry of Agriculture, College of Veterinary Medicine, South China Agricultural University, 483 Wushan Road, Tianhe District, Guangzhou 510642, People s Republic of China
    J Clin Microbiol 48:2116-21. 2010
    Infection of breeder flocks in China with subgroup J avian leukosis virus (ALV-J) has increased recently...
  13. pmc Actin- and myosin-driven movement of viruses along filopodia precedes their entry into cells
    Maik J Lehmann
    Section of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06536, USA
    J Cell Biol 170:317-25. 2005
    ..Our results reveal another example of viruses hijacking host machineries for efficient infection by using the inherent ability of filopodia to transport ligands to the cell body...
  14. ncbi Effects of lipid rafts on dynamics of retroviral entry and trafficking: Quantitative analysis
    Kwang il Lim
    Department of Chemical and Biological Engineering, University of Wisconsin Madison, 53706 USA
    Biotechnol Bioeng 86:650-60. 2004
    ..Overall, the model provides a means to generate new experimentally testable hypotheses and sets a foundation for building a quantitative and integrated understanding of viral entry, trafficking, and intracellular dynamics...
  15. pmc The receptor for the subgroup C avian sarcoma and leukosis viruses, Tvc, is related to mammalian butyrophilins, members of the immunoglobulin superfamily
    Daniel Elleder
    Department of Cellular and Viral Genetics, Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Prague
    J Virol 79:10408-19. 2005
    ..We have also identified a mutation in the tvc gene in line L15 chickens that explains why this line is resistant to ASLV(C) infection...
  16. pmc Low pH is required for avian sarcoma and leukosis virus Env-dependent viral penetration into the cytosol and not for viral uncoating
    Richard J O Barnard
    McArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin Madison, USA
    J Virol 78:10433-41. 2004
    ..These studies provide strong support for the model, indicating that low pH is required for ASLV Env-dependent viral penetration into the cytosol and not for viral uncoating...
  17. pmc Recombinant avian leukosis viruses of subgroup J isolated from field infected commercial layer chickens with hemangioma and myeloid leukosis possess an insertion in the E element
    Xiaoping Wu
    Key Lab of Jiangsu Preventive Veterinary Medicine, College of Veterinary Medicine, Yangzhou University, No 12 East Wenhui Road, Yangzhou, Jiangsu Province, China, 225009
    Vet Res Commun 34:619-32. 2010
    Five isolates (JS09GY2, JS09GY3, JS09GY4, JS09GY5, and JS09GY6) of avian leukosis virus subgroup J (ALV-J) were isolated from six infected commercial layer flocks displaying both hemangioma and myeloid leukosis (ML), which shared the same ..
  18. ncbi Phylogenetic analysis of subgroup J avian leucosis virus from broiler and native chickens in Taiwan during 2000-2002
    Wen Liang Thu
    Department of Veterinary Medicine, National Taiwan University, Taipei, Taiwan
    J Vet Med Sci 65:325-8. 2003
    ..The high similarities observed in different ALV-J isolates suggest that different ALV-Js were mixed in the pedigree generations in different breeding lines...
  19. ncbi c-erbB activation in ALV-induced erythroblastosis: novel RNA processing and promoter insertion result in expression of an amino-truncated EGF receptor
    T W Nilsen
    Cell 41:719-26. 1985
    ..These results establish a novel pathway of promoter insertion oncogenesis that stands in contrast to the pathways used in the activation of c-myc in B lymphomas...
  20. ncbi Comparison of Chinese field strains of avian leukosis subgroup J viruses with prototype strain HPRS-103 and United States strains
    Zhizhong Cui
    College of Animal Science and Veterinary Medicine, Shandong Agricultural University, Taian 271018, P R China
    Avian Dis 47:1321-30. 2003
    ..The result implies that envelope gp85 may not have diverged from prototype and older strains. It is also possible that some recently imported birds could have been infected by the older viruses that were introduced in the late 1990s...
  21. pmc Sequence analysis for the complete proviral genome of subgroup J Avian Leukosis virus associated with hemangioma: a special 11 bp deletion was observed in U3 region of 3'UTR
    Min Shi
    College of Veterinary Medicine, Sichuan Agricultural University, Ya an, Sichuan 625014, China
    Virol J 8:158. 2011
    b>Avian Leukosis virus (ALV) of subgroup J (ALV-J) belong to retroviruses, which could induce tumors in domestic and wild birds...
  22. pmc Two different molecular defects in the Tva receptor gene explain the resistance of two tvar lines of chickens to infection by subgroup A avian sarcoma and leukosis viruses
    Daniel Elleder
    Department of Cellular and Viral Genetics, Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Prague
    J Virol 78:13489-500. 2004
    ..Line 7(2) tva(r2) contains a 4-bp insertion in exon 1 that causes a change in the reading frame, which blocks expression of the Tva receptor...
  23. pmc Lack of evidence of endogenous avian leukosis virus and endogenous avian retrovirus transmission to measles, mumps, and rubella vaccine recipients
    A I Hussain
    Centers for Disease Control and Prevention, 1600 Clifton Road, Mail Stop G19, Atlanta, GA 30333, USA
    Emerg Infect Dis 7:66-72. 2001
    The identification of endogenous avian leukosis virus (ALV) and endogenous avian retrovirus (EAV) in chick cell-derived measles and mumps vaccines in current use has raised concern about transmission of these retroviruses to vaccine ..
  24. ncbi E (XSR) element contributes to the oncogenicity of Avian leukosis virus (subgroup J)
    Peter M Chesters
    Viral Oncogenesis Group, Division of Microbiology, Institute for Animal Health, Compton, Berkshire RG20 7NN, UK
    J Gen Virol 87:2685-92. 2006
    Among the six subgroups of Avian leukosis virus (ALV) that infect chickens, subgroup J (ALV-J) was isolated from meat-type chickens where it predominantly induces myeloid leukosis (ML) and erythroblastosis (EB)...
  25. ncbi Cardiomyopathy in broiler chickens congenitally infected with avian leukosis virus subgroup J
    N L Stedman
    Athens Diagnostic Laboratory, College of Veterinary Medicine, University of Georgia, 30602, USA
    Vet Pathol 39:161-4. 2002
    ..are frequently associated with rapid growth and pulmonary hypertension, but can be associated with some avian leukosis virus (ALV) infections...
  26. ncbi Influence of strain, dose of virus, and age at inoculation on subgroup J avian leukosis virus persistence, antibody response, and oncogenicity in commercial meat-type chickens
    Arun R Pandiri
    U S Department of Agriculture Agricultural Research Service, Avian Disease and Oncology Laboratory, 3606 East Mount Hope Road, East Lansing, MI 48823, USA
    Avian Dis 51:725-32. 2007
    The effects of viral strain, viral dose, and age of bird at inoculation on subgroup J avian leukosis virus (ALV J) persistence, neutralizing antibody (VNAb) response, and tumors were studied in commercial meat-type chickens...
  27. ncbi Alpharetrovirus envelope-receptor interactions
    R J O Barnard
    McArdle Laboratories for Cancer Research, Department of Oncology, University of Wisconsin Madison, 1400 University Ave, Madison, WI 53706, USA
    Curr Top Microbiol Immunol 281:107-36. 2003
    ..In addition, we review data pertaining to the novel two-step entry mechanism of ASLV entry and propose a model by which ASLV Env elicits membrane fusion...
  28. ncbi Replacement of primary chicken embryonic fibroblasts (CEF) by the DF-1 cell line for detection of avian leucosis viruses
    Riks Maas
    Central Institute of Animal Disease Control CIDC Lelystad, P O Box 2004, 8203 AA Lelystad, The Netherlands
    Biologicals 34:177-81. 2006
    ..For reasons of sensitivity, standardisation as well as reduction of animal use, the data support the use of DF-1 cells to monitor absence of ALV in vaccine virus seed lots or finished products...
  29. ncbi Molecular indications for in vivo integration of the avian leukosis virus, subgroup J-long terminal repeat into the Marek's disease virus in experimentally dually-infected chickens
    I Davidson
    Division of Avian Diseases, Kimron Veterinary Institute, Bet Dagan, Israel
    Virus Genes 24:173-80. 2002
    Marek's disease virus, a herpesvirus, and avian leukosis virus, subgroup J, a retrovirus, are oncogenic viruses of poultry. Both viruses may infect the same flock, the same bird and the same cell...
  30. pmc bic, a novel gene activated by proviral insertions in avian leukosis virus-induced lymphomas, is likely to function through its noncoding RNA
    W Tam
    Cornell University Graduate School of Medical Sciences, Sloan Kettering Institute for Cancer Research, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Mol Cell Biol 17:1490-502. 1997
    The bic locus is a common retroviral integration site in avian leukosis virus (ALV)-induced B-cell lymphomas originally identified by infection of chickens with ALVs of two different subgroups (Clurman and Hayward, Mol. Cell. Biol...
  31. ncbi Detection of avian leukosis virus subgroup J in chicken flocks from Malaysia and their molecular characterization
    B R Thapa
    Department of Veterinary Pathology and Microbiology, Faculty of Veterinary Medicine, Universiti Putra Malaysia, Serdang, Selangor Darul Ehsan, Malaysia
    Avian Pathol 33:359-63. 2004
    Previously we have shown that avian leukosis virus subgroup J (ALV-J) might be present in chicken flocks from Malaysia based on serological study and also on detection of tissue samples with myelocytic infiltration...
  32. ncbi Intraembryonic avian leukosis virus subgroup C (ALV-C) inoculation producing wasting disease in ducks soon after hatching
    V Stepanets
    Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Folia Biol (Praha) 49:100-9. 2003
    ..On the basis of these and additional observations we propose that inoculation of duck embryos provides a suitable model for analysis of the wasting disease produced by ALV-C...
  33. ncbi Response of white leghorn chickens of various genetic lines to infection with avian leukosis virus subgroup J
    Susan M Williams
    U S Department of Agriculture, Agricultural Research Service, Avian Disease and Oncology Laboratory, 3606 East Mount Hope Road, East Lansing, MI 48823, USA
    Avian Dis 48:61-7. 2004
    ..chickens from various white leghorn experimental lines were inoculated with strain ADOL-Hcl of subgroup J avian leukosis virus (ALV-J) either as embryos or at 1 day of age...
  34. pmc Low pH is required for avian sarcoma and leukosis virus Env-induced hemifusion and fusion pore formation but not for pore growth
    G B Melikyan
    Department of Molecular Biophysics and Physiology, Rush Medical College, Chicago, Illinois 60612, USA
    J Virol 78:3753-62. 2004
    ..At this point, but not before, low pH can induce fusion and is in fact required for fusion to occur. However, low pH is no longer necessary after formation of the initial fusion pore: pore enlargement does not require low pH...
  35. pmc Avian bic, a gene isolated from a common retroviral site in avian leukosis virus-induced lymphomas that encodes a noncoding RNA, cooperates with c-myc in lymphomagenesis and erythroleukemogenesis
    Wayne Tam
    Graduate Program in Molecular Biology, Joan and Sanford Weill Graduate School of Medical Sciences of Cornell University, New York, New York 10021, USA
    J Virol 76:4275-86. 2002
    bic is a novel gene identified at a common retroviral integration site in avian leukosis virus-induced lymphomas and has been implicated as a collaborator with c-myc in B lymphomagenesis...
  36. ncbi Response of white leghorn chickens of various B haplotypes to infection at hatch with subgroup J avian leukosis virus
    Jody K Mays
    U S Department of Agriculture, Agricultural Research Service, Avian Disease and Oncology Laboratory, 3606 East Mount Hope Road, East Lansing, MI 48823, USA
    Avian Dis 49:214-9. 2005
    ..B semicongenic lines were infected at hatch with strain ADOL Hc-1 of subgroup J avian leukosis virus (ALV-J)...
  37. pmc Novel monoclonal antibody directed at the receptor binding site on the avian sarcoma and leukosis virus Env complex
    Christina Ochsenbauer-Jambor
    Department of Microbiology, School of Medicine, University of Alabama at Birmingham, 35294, USA
    J Virol 76:7518-27. 2002
    ..Thus, anti-ASLV-SU-A mc8C5-4 proves to be a unique new immunoreagent that targets the receptor-binding site on a prototypical retroviral envelope...
  38. ncbi The viral envelope is a major determinant for the induction of lymphoid and myeloid tumours by avian leukosis virus subgroups A and J, respectively
    P M Chesters
    Viral Oncogenesis Group, Institute for Animal Health, Compton, Berkshire RG20 7NN, UK
    J Gen Virol 83:2553-61. 2002
    Among the six envelope subgroups of avian leukosis virus (ALV) that infect chickens, subgroups A (ALV-A) and J (ALV-J) are the most pathogenic and widespread among commercial chicken populations...
  39. ncbi Development and validation of a PCR-RFLP assay to evaluate TVB haplotypes coding receptors for subgroup B and subgroup E avian leukosis viruses in White Leghorns
    H M Zhang
    US Department of Agriculture, Agricultural Research Service, Avian Disease and Oncology Laboratory, 3606 East Mount Hope Road, East Lansing, MI 48823, USA
    Avian Pathol 34:324-31. 2005
    The cellular receptor of subgroup B avian leukosis virus (ALVB) is encoded by a gene at the tumour virus B (TVB) locus...
  40. ncbi Diagnosis of myeloid leukosis induced by a recombinant avian leukosis virus in commercial white leghorn egg laying flocks
    Eric Gingerich
    University of Pennsylvania, New Bolton Center Poultry Laboratory, Kennett Square 19348 1692, USA
    Avian Dis 46:745-8. 2002
    ..The diagnosis of myeloid leukosis was confirmed by the isolation of a recombinant avian leukosis virus (ALV) containing the LTR of subgroup J and the envelope of subgroup B ALV...
  41. ncbi Epitope selection from an uncensored peptide library displayed on avian leukosis virus
    Pranay D Khare
    Molecular Medicine Program, Mayo Clinic Rochester, Rochester, MN 55905, USA
    Virology 315:313-21. 2003
    ..of various sizes could be efficiently displayed on the envelope glycoproteins of a eukaryotic virus, avian leukosis virus (ALV), and the displayed polypeptides could efficiently attach to cognate receptors without interfering ..
  42. ncbi Methods for evaluating and developing commercial chicken strains free of endogenous subgroup E avian leukosis virus
    L D Bacon
    US Department of Agriculture Agricultural Research Service, Avian Disease and Oncology Laboratory, East Lansing, MI 48823, USA
    Avian Pathol 33:233-43. 2004
    The genome of nearly all chickens contains various DNA proviral insertions of retroviruses of subgroup E avian leukosis virus (ALVE)...
  43. pmc Evolutionary pressure of a receptor competitor selects different subgroup a avian leukosis virus escape variants with altered receptor interactions
    Deborah C Melder
    Department of Health Sciences Research, Section of Biostatistics, Mayo Clinic Rochester, Rochester, Minnesota 55905, USA
    J Virol 77:10504-14. 2003
    ..Alterations in the normally extreme specificity of the ALV(A) glycoproteins for Tva may represent an evolutionary first step toward expanding viral receptor usage in response to inefficient viral entry...
  44. ncbi Effect of an in ovo infection with a Dutch avian leukosis virus subgroup J isolate on the growth and immunological performance of SPF broiler chickens
    W J M Landman
    Animal Health Service, Poultry Health Centre, Deventer, The Netherlands
    Avian Pathol 31:59-72. 2002
    The effect of an in ovo infection with a Dutch isolate of avian leukosis virus subgroup J (ALV-J) on the growth of specific pathogen free (SPF) broiler chickens was analysed...
  45. pmc Heptad repeat 2-based peptides inhibit avian sarcoma and leukosis virus subgroup a infection and identify a fusion intermediate
    Robert C Netter
    Department of Microbiology, University of Pennsylvania School of Medicine, 225 Johnson Pavilion, 3610 Hamilton Walk, Philadelphia, PA 19104 6076, USA
    J Virol 78:13430-9. 2004
    ..These experiments support a model in which receptor interaction promotes formation of an envelope conformation in which the TM subunit is stably associated with its target membrane and is able to bind a C-terminal peptide...
  46. ncbi Occurrence of avian leukosis virus subgroup J in commercial layer flocks in China
    Binrui Xu
    College of Veterinary Medicine, China Agricultural University, Beijing, China
    Avian Pathol 33:13-7. 2004
    ..Immunohistochemical studies with a monoclonal antibody to gp85 of avian leukosis virus subgroup J (ALV-J) revealed antigen in all organs examined...
  47. ncbi Detection of subgroup J avian leukosis virus infection in Australian meat-type chickens
    T J Bagust
    School of Veterinary Science, The University of Melbourne, Parkville, Victoria
    Aust Vet J 82:701-6. 2004
    To determine the extent of avian leukosis virus subgroup J (ALV-J) infection in Australian broiler breeder flocks, using virus isolation and molecular biological detection...
  48. pmc Na+/H+ exchanger type 1 is a receptor for pathogenic subgroup J avian leukosis virus
    Ning Chai
    Department of Microbiology, University of Pennsylvania School of Medicine, 225 Johnson Pavilion, 3610 Hamilton Walk, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 103:5531-6. 2006
    Subgroup J avian leukosis virus (ALV-J) is a recently identified avian oncogenic retrovirus responsible for severe economic losses worldwide...
  49. ncbi Development and characterization of monoclonal antibodies to subgroup J avian leukosis virus
    A Qin
    USDA Agricultural Research Service, Avian Disease and Oncology Laboratory, East Lansing, MI 48823, USA
    Avian Dis 45:938-45. 2001
    In an attempt to develop a specific diagnostic test for avian leukosis virus (ALV) subgroup J (ALV-J) strain Hc1, four monoclonal antibodies (MAbs), JE9, G2, 145, and J47, were generated that are specific for ALV-J envelope glycoprotein, ..
  50. doi A recombinant avian leukosis virus associated with fowl glioma in layer chickens in Japan
    Hitoshi Hatai
    Laboratory of Comparative Pathology, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan
    Avian Pathol 37:127-37. 2008
    ..is characterized by multiple nodular growth of astrocytes, and fowl glioma-inducing virus belonging to avian leukosis virus has been isolated from Japanese bantam as a causal agent...
  51. pmc Targeting avian leukosis virus subgroup A vectors by using a TVA-VEGF bridge protein
    S Snitkovsky
    Committee on Virology, Boston, Massachusetts 02115, USA
    J Virol 75:1571-5. 2001
    Previously, we have demonstrated that bridge proteins comprised of avian leukosis virus (ALV) receptors fused to epidermal growth factor (EGF) can be used to selectively target retroviral vectors with ALV envelope proteins to cells ..
  52. ncbi Locus-specific diagnostic tests for endogenous avian leukosis-type viral loci in chickens
    B F Benkel
    Agriculture and Agri Food Canada, Centre for Food and Animal Research, Ottawa, Ontario
    Poult Sci 77:1027-35. 1998
    ..In addition, it compares the insertion sites of these elements in an effort to identify common motifs at ALVE integration sites...
  53. pmc Genetic mapping of the cloned subgroup A avian sarcoma and leukosis virus receptor gene to the TVA locus
    P Bates
    Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia 19104 6076, USA
    J Virol 72:2505-8. 1998
    ..However, analysis of the genomic sequence encoding this region of Tva in randomly bred chickens suggests that the altered virus binding domain is not the basis for genetic resistance in the chicken lines analyzed...
  54. ncbi Epidemiological and pathological studies of subgroup J avian leukosis virus infections in Chinese local "yellow" chickens
    Shuhong Sun
    College of Veterinary Medicine, Shandong Agricultural University, Taian, Peoples Republic of China
    Avian Pathol 36:221-6. 2007
    Epidemiological, pathological and molecular studies indicate that subgroup J avian leukosis virus (ALV-J) infections are widely spread in "yellow chickens" of local breeds in China...
  55. ncbi Genetic variation at the tumour virus B locus in commercial and laboratory chicken populations assessed by a medium-throughput or a high-throughput assay
    H M Zhang
    USDA, ARS, Avian Disease and Oncology Laboratory, East Lansing, MI 48823, USA
    Avian Pathol 36:283-91. 2007
    The tumour virus B (TVB) locus encodes cellular receptors mediating infection by three subgroups of avian leukosis virus (B, D, and E). Three major alleles, TVB*S1, TVB*S3, and TVB*R, have been described...
  56. ncbi Development of an endogenous virus-free line of chickens susceptible to all subgroups of avian leukosis virus
    Huanmin Zhang
    U S Department of Agriculture, Agriculture Research Service, Avian Disease and Oncology Laboratory, 3606 E Mount Hope Road, East Lansing, MI 48823, USA
    Avian Dis 52:412-8. 2008
    ..This report documents the development of a new line of chickens, 0.TVB*S1, that is free of endogenous viruses and susceptible to all subgroups of ALV identified in chickens...
  57. pmc Telomerase reverse transcriptase expression elevated by avian leukosis virus integration in B cell lymphomas
    Feng Yang
    Department of Biology, The Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218, USA
    Proc Natl Acad Sci U S A 104:18952-7. 2007
    ..In this study, we identified avian leukosis virus (ALV) proviral integration sites in rapid-onset B cell lymphomas arising <12 weeks after infection of ..
  58. ncbi [The identification and sequence analysis of ALV-J isolated from layers]
    Hui Wang
    College of Animal Science and Technology, Shandong Agricultural University, Tai an 271018
    Bing Du Xue Bao 24:369-75. 2008
    ....
  59. ncbi Molecular epidemiology of avian leukosis virus subgroup J and evolutionary history of its 3' untranslated region
    G Zavala
    Poultry Diagnostic and Research Center, Department of Population Health, University of Georgia, Athens, GA 30602, USA
    Avian Dis 51:942-53. 2007
    ..Some of the mutations in the 3' UTR have resulted in the emergence of moderately distinct genetic lineages representing each primary breeding company from which ALV-J was isolated...
  60. ncbi Inhibition of avian leukosis virus replication by vector-based RNA interference
    Mo Chen
    Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI 48824, USA
    Virology 365:464-72. 2007
    ..study, replication competent retroviral vectors were designed to deliver shRNA-mirs targeting subgroup B avian leukosis virus (ALV), the most effective of which reduced expression of protein targets by as much as 90% in cultured ..
  61. ncbi Ubiquitin in avian leukosis virus particles
    D Putterman
    Section of Biochemistry, Molecular and Cell Biology, Cornell University, Ithaca, New York 14853
    Virology 176:633-7. 1990
    We have identified unconjugated ubiquitin as a component of avian leukosis virus (ALV). Quantitation both by immunoblotting and by protein staining showed that ubiquitin makes up about 0...
  62. ncbi Major rearrangements in the E element and minor variations in the U3 sequences of the avian leukosis subgroup J provirus isolated from field myelocytomatosis
    D Hue
    UPR 1282, INRA, Centre de Recherches de Tours, Nouzilly, France
    Arch Virol 151:2431-46. 2006
    We collected paraffin-embedded myelocytomatoses induced by subgroup J avian leukosis virus (ALV-J) in French poultry from 1992 to 2000...
  63. pmc Identification and characterization of a shared TNFR-related receptor for subgroup B, D, and E avian leukosis viruses reveal cysteine residues required specifically for subgroup E viral entry
    H B Adkins
    Department of Microbiology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Virol 74:3572-78. 2000
    ..Thus, ALV-B and ALV-E interact in fundamentally different ways with this shared receptor, a finding that may account for the observed biological differences between these two ALV subgroups...
  64. pmc Characterization of endogenous avian leukosis viruses in chicken embryonic fibroblast substrates used in production of measles and mumps vaccines
    J A Johnson
    HIV and Retrovirology Branch, Division of AIDS, STD, and TB Laboratory Research, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Virol 75:3605-12. 2001
    ..Our data demonstrate that both defective and nondefective ev loci can be present in CEF vaccine substrates and suggest that both ev classes may contribute to the ALV present in vaccines...
  65. ncbi Susceptibility of various parental lines of commercial white leghorn layers to infection with a naturally occurring recombinant avian leukosis virus containing subgroup B envelope and subgroup J long terminal repeat
    Jody K Mays
    U S Department of Agriculture, Agricultural Research Service, Avian Disease and Oncology Laboratory, 3606 East Mount Hope Road, East Lansing, MI 48823, USA
    Avian Dis 50:342-7. 2006
    ..White Leghorn layer flocks from three independent breeders were inoculated with a naturally occurring avian leukosis virus (ALV) containing an ALV-B envelope and an ALV-J long terminal repeat (LTR) termed ALV-B/J...
  66. pmc Identification of key residues in subgroup A avian leukosis virus envelope determining receptor binding affinity and infectivity of cells expressing chicken or quail Tva receptor
    S L Holmen
    Molecular Medicine Program, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
    J Virol 75:726-37. 2001
    To better understand retroviral entry, we have characterized the interactions between subgroup A avian leukosis virus [ALV(A)] envelope glycoproteins and Tva, the receptor for ALV(A), that result in receptor interference...
  67. ncbi Molecular and biological characterization of a naturally occurring recombinant subgroup B avian leukosis virus with a subgroup J-like long terminal repeat
    Blanca Lupiani
    Department of Veterinary Pathobiology, College of Veterinary Medicine, Texas A and M University, College Station, TX 77843, USA
    Avian Dis 50:572-8. 2006
    Infection of broiler chickens with subgroup J avian leukosis virus (ALV) results in the induction of myeloid tumors...
  68. pmc Multiple complex families of endogenous retroviruses are highly conserved in the genus Gallus
    M T Boyce-Jacino
    Institute of Human Genetics, University of Minnesota, Minneapolis 55455
    J Virol 66:4919-29. 1992
    ....
  69. ncbi High virus titer in feather pulp of chickens infected with subgroup J avian leukosis virus
    H W Sung
    U S Department of Agriculture, Agricultural Research Service, Avian Disease and Oncology Laboratory, East Lansing, MI 48823, USA
    Avian Dis 46:281-6. 2002
    ..All above results indicate that samples of feather pulp can be useful for virus isolation and PCR to confirm subgroup J ALV infection...
  70. ncbi Polymerase chain reaction for detection of avian leukosis virus subgroup J in feather pulp
    Guillermo Zavala
    Department of Avian Medicine, College of Veterinary Medicine, The University of Georgia, Athens, GA 30602, USA
    Avian Dis 46:971-8. 2002
    ..infected chickens was used as a source of DNA for polymerase chain reaction (PCR) amplification of avian leukosis virus subgroup J (ALV-J) proviral DNA...
  71. pmc The mature avian leukosis virus subgroup A envelope glycoprotein is metastable, and refolding induced by the synergistic effects of receptor binding and low pH is coupled to infection
    Jason G Smith
    Department of Medicine Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Virol 78:1403-10. 2004
    ..As a test of this hypothesis, the requirements for avian leukosis virus A (ALV-A) infection were examined...
  72. pmc Avian endogenous retrovirus EAV-HP shares regions of identity with avian leukosis virus subgroup J and the avian retrotransposon ART-CH
    M A Sacco
    Institute for Animal Health, Compton, Newbury, Berkshire RG20 7NN, United Kingdom
    J Virol 74:1296-306. 2000
    ..elements in the chicken genome, designated EAV-HP, with close sequence identity to the env gene of avian leukosis virus (ALV) subgroup J has been reported (L. M. Smith, A. A. Toye, K. Howes, N. Bumstead, L. N. Payne, and K...
  73. pmc Bystander killing during avian leukosis virus subgroup B infection requires TVB(S3) signaling
    Felipe Diaz-Griffero
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Virol 77:12552-61. 2003
    Cell killing by avian leukosis virus subgroup B (ALV-B) in cultures has been extensively studied, but the molecular basis of this process has not been established...
  74. ncbi Naturally occurring multiple perineuriomas in a chicken (Gallus domesticus)
    A Ochi
    Laboratory of Comparative Pathology, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060 0818, Japan
    Vet Pathol 45:685-9. 2008
    ..On the basis of microscopic, histologic, and immunohistochemical findings, the tumors were diagnosed as multiple perineuriomas...
  75. ncbi Identification of glycosylation sites in the SU component of the Avian Sarcoma/Leukosis virus Envelope Glycoprotein (Subgroup A) by mass spectrometry
    Mamuka Kvaratskhelia
    Center for Retrovirus Research and Comprehensive Cancer Center, College of Pharmacy, The Ohio State University Health Sciences Center, Columbus, OH 43210, USA
    Virology 326:171-81. 2004
    ..Removing most of the carbohydrate from the mature SU(A)-rIgG by PNGase F treatment greatly reduces the ability of the protein to bind Tva, suggesting that carbohydrate may play a direct role in receptor binding...
  76. ncbi Prevalence of fowl glioma-inducing virus in chickens of zoological gardens in Japan and nucleotide variation in the env gene
    Hitoshi Hatai
    Laboratory of Comparative Pathology, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan
    J Vet Med Sci 70:469-74. 2008
    Fowl glioma-inducing virus (FGV), which belongs to subgroup A of avian leukosis virus (ALV), is tumorigenic in the nervous system...
  77. ncbi Reduced Myc overexpression and normal B-cell differentiation mediate resistance to avian leukosis virus lymphomagenesis
    Sean S Parghi
    Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, PO Box 19024, MS C2 023, Seattle, WA 98109, USA
    Oncogene 23:4413-21. 2004
    b>Avian leukosis virus (ALV) induces bursal lymphoma in tumor-susceptible chicken strains after proviral integration within the c-myc gene, and subsequent expansion of Myc-overexpressing lymphocytes within transformed follicles...
  78. ncbi Histopathological characteristics of spindle-cell proliferative disease in broiler chickens and its experimental reproduction in specific pathogen-free chickens
    Shigeaki Takami
    Department of Pathogenic Veterinary Science, The United Graduate School of Veterinary Sciences, Gifu University, Japan
    J Vet Med Sci 66:231-5. 2004
    ..Reverse transcriptase-polymerase chain reaction performed using primers specific for subgroup J avian leukosis virus (ALV) produced specific amplifications of subgroup J ALV genes in 4 of 5 field cases examined.
  79. pmc Quantitative evaluation of DNA methylation patterns for ALVE and TVB genes in a neoplastic disease susceptible and resistant chicken model
    Ying Yu
    Department of Animal and Avian Sciences, University of Maryland, College Park, Maryland, USA
    PLoS ONE 3:e1731. 2008
    Chicken endogenous viruses, ALVE (Avian Leukosis Virus subgroup E), are inherited as LTR (long terminal repeat) retrotransposons, which are negatively correlated with disease resistance, and any changes in DNA methylation may contribute ..
  80. ncbi Myotropic avian leukosis virus subgroup J infection in a chicken
    G Sironi
    Dipartimento di Patologia Animale, Igiene e Sanita Pubblica Veterinaria, Universita degli Studi di Milano, Via Celoria 10, 20133 Milan, Italy
    J Vet Med B Infect Dis Vet Public Health 53:347-9. 2006
    The study describes a highly productive myotropic avian leukosis virus infection (ALV) in a 3-month-old female chicken. At necropsy, ascites, hepatic fibrosis and cardiomegaly were seen...
  81. ncbi Experimental infection with avian leukosis virus isolated from Marek's disease vaccines
    Guillermo Zavala
    Department of Population Health, University of Georgia, Athens 30602, USA
    Avian Dis 50:232-7. 2006
    Recently, avian leukosis virus (ALV) was isolated from four lots of Marek's disease vaccine produced by two laboratories...
  82. ncbi Isolation and characterization of an adventitious avian leukosis virus isolated from commercial Marek's disease vaccines
    Aly Fadly
    USDA, Agricultural Research Service, Avian Disease and Oncology Laboratory, East Lansing, Michigan 48823, USA
    Avian Dis 50:380-5. 2006
    ..Marek's disease (MD) vaccines produced by two manufacturers were tested for possible contamination with avian leukosis virus (ALV)...
  83. ncbi Differences in pathogenicity among strains of the same or different avian leukosis virus subgroups
    Dana Pruková
    Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Flemingovo nam 2, CZ 166 37, Prague 6, Czech Republic
    Avian Pathol 36:15-27. 2007
    An efficient induction of wasting disease in chickens by avian leukosis virus (ALV), particularly ALV subgroup C, requires >102 infectious units virus inoculated in mid embryogenesis...
  84. ncbi Basophilic intracytoplasmic viral matrix inclusions distributed widely in layer hens affected with avian-leukosis-virus-associated tumours
    Kikuyasu Nakamura
    National Institute of Animal Health Kannondai, Tsukuba, Ibaraki 305 0856 Japan
    Avian Pathol 36:53-8. 2007
    ..MIs in the various tissues were strongly positive for the avian leukosis virus (ALV) antigen...
  85. ncbi Reduced serologic response to Newcastle disease virus in broiler chickens exposed to a Chinese field strain of subgroup J avian leukosis virus
    Zhizhong Cui
    Department of Preventive Veterinary Medicine, College of Animal Science and Veterinary Medicine, Shandong Agricultural University, Taian, P R China
    Avian Dis 50:191-5. 2006
    In this study, a Chinese field strain of subgroup J avian leukosis virus (ALV-J), NX0101, was studied for its immunosuppressive effects in both commercial broilers and SPF white Leghorn chickens infected at 1 day of age...
  86. ncbi Single and concurrent avian leukosis virus infections with avian leukosis virus-J and avian leukosis virus-A in Australian meat-type chickens
    Simon P Fenton
    School of Veterinary Science, University of Melbourne, Parkville, Victoria 3052, Australia
    Avian Pathol 34:48-54. 2005
    ..as the ongoing occurrence of ALV-A in meat-type birds, is discussed in the context of ongoing potential for recombinations and the associated threat for the emergence of avian leukosis virus with changes in host range and pathogenicity.
  87. ncbi Detection and localization of naturally transmitted avian leukosis subgroup J virus in egg-type chickens by in situ PCR hybridization
    N Li
    College of Veterinary Medicine, China Agricultural University, Beijing 100094, China
    J Vet Med A Physiol Pathol Clin Med 54:553-8. 2007
    b>Avian leukosis virus (ALV) subgroup J (ALV-J) is an exogenous ALV and causes myeloid leukosis in meat-type chickens...
  88. pmc Assessing the roles of endogenous retrovirus EAV-HP in avian leukosis virus subgroup J emergence and tolerance
    Melanie A Sacco
    Institute for Animal Health, Compton, Newbury, Berkshire, United Kingdom
    J Virol 78:10525-35. 2004
    b>Avian leukosis virus (ALV) subgroup J is thought to have emerged through a recombination event between an unknown exogenous ALV and the endogenous retrovirus elements designated EAV-HP...
  89. doi Distribution of viral antigen gp85 and provirus in various tissues from commercial meat-type and experimental White Leghorn Line 0 chickens with different subgroup J avian leukosis virus infection profiles
    A R Pandiri
    USDA ARS Avian Disease and Oncology Laboratory, East Lansing, MI 48823, USA
    Avian Pathol 37:7-13. 2008
    Immunohistochemistry and polymerase chain reaction (PCR) were used to test for the presence of avian leukosis virus (ALV) J viral antigen gp85 and proviral DNA, respectively, in various tissues (adrenal gland, bone marrow, gonad, heart, ..
  90. ncbi Seroprevalence of avian influenza virus, infectious bronchitis virus, reovirus, avian pneumovirus, infectious laryngotracheitis virus, and avian leukosis virus in Nigerian poultry
    A A Owoade
    Department of Veterinary Medicine, University of Ibadan, Nigeria
    Avian Dis 50:222-7. 2006
    ..avian pneumovirus (APV), infectious laryngotracheitis virus (ILTV), avian influenza virus (AIV), and avian leukosis virus (ALV)...
  91. ncbi The effects of cyclophosphamide treatment on the pathogenesis of subgroup J avian leukosis virus (ALV-J) infection in broiler chickens with Marek's disease virus exposure
    Yongbaek Kim
    Department of Veterinary Pathology, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA
    J Vet Sci 5:49-58. 2004
    Studies were performed to determine the effects of Bcell suppression on the pathogenesis of Subgroup J avian leukosis virus (ALV-J) in broiler chickens...
  92. ncbi Development and application of reverse transcriptase nested polymerase chain reaction test for the detection of exogenous avian leukosis virus
    Maricarmen Garcia
    Department of Avian Medicine, Poultry Diagnostic and Research Center, College of Veterinary Medicine, The University of Georgia, Athens, GA 30602 4875, USA
    Avian Dis 47:41-53. 2003
    ..PCR) assay that utilizes nested primers to amplify a fragment of the long terminal repeat of exogenous avian leukosis virus (ALV) was developed and evaluated for detection of ALV subgroup J directly from clinical samples...
  93. ncbi Fertility and sperm quality of broiler breeder males infected with subgroup J avian leukosis virus
    Benton P Hudson
    Department of Poultry Science, The University of Georgia, Athens, GA 30602 4875, USA
    Avian Dis 46:1033-7. 2002
    In order to assess the effects of subgroup J avian leukosis virus (ALV-J) on semen quality, broiler breeder males were separated by ALV-J status (ALV-J positive = POS, ALV-J negative = NEG) at 44 wk of age...
  94. ncbi Persistence of chicken herpesvirus and retroviral chimeric molecules upon in vivo passage
    R Borenshtain
    Division of Avian Diseases, Kimron Veterinary Institute, Bet Dagan, P O Box 12, Israel 50250
    Avian Dis 47:296-308. 2003
    ..The findings show that, in four out of seven groups of the second trial, the chimeric molecule species persisted on passage...
  95. ncbi Pathogenicity of two recombinant avian leukosis viruses
    Blanca Lupiani
    U S Department of Agriculture, Agricultural Research Service, Avian Disease and Oncology Laboratory, 3606 East Mount Hope Road, East Lansing, MI 48823, USA
    Avian Dis 47:425-32. 2003
    ..and molecular characteristics of two recombinant avian leukosis subgroup J viruses (ALV J) with an avian leukosis virus subgroup A envelope (r5701A and r6803A)...
  96. ncbi Occurrence of subgroup J avian leukosis virus in Taiwan
    C H Wang
    Department of Veterinary Medicine, National Taiwan University, P O Box 23 3, Taipei 106, Taiwan
    Avian Pathol 31:435-9. 2002
    ..One of these farms, populated by breast meat yield chickens (yield type), suffered from a severe subgroup J avian leukosis virus (ALV-J) infection in mid-1997...
  97. ncbi The effects of avian leukosis virus subgroup J on broiler chicken performance and response to vaccination
    E Spackman
    Southeast Poultry Research Lab, USDA, Agricultural Research Service, 934 College Station Road, Athens, GA 30605, USA
    Avian Dis 47:618-26. 2003
    The effects of avian leukosis virus subgroup J (ALV-J) infection on meat-type chickens reared in a simulated commercial setting were evaluated...
  98. ncbi Serologic profiles of chickens infected with subgroup J avian leukosis virus
    Chyi Sing Hwang
    Department of Veterinary Medicine, National Taiwan University, Taipei
    Avian Dis 46:598-604. 2002
    Subgroup J avian leukosis virus (ALV-J) causes serious economic losses in the commercial poultry industry...
  99. ncbi In ovo infection with an avian leukosis virus causing fowl glioma: viral distribution and pathogenesis
    Y Tomioka
    Laboratory of Comparative Pathology, Hokkaido University, Sapporo, Japan
    Avian Pathol 32:617-24. 2003
    We have previously isolated an avian leukosis virus (ALV) from a chicken affected with so-called fowl glioma. A resistance-inducing factor test indicated that the isolate was classified into a subgroup A...
  100. ncbi Immunohistochemical localization of avian leukosis virus subgroup J in tissues from naturally infected chickens
    S Gharaibeh
    Department of Avian Medicine, University of Georgia, Athens 30602, USA
    Avian Dis 45:992-8. 2001
    The tissue tropism of avian leukosis virus (ALV) subgroup J (ALV-J) was investigated in congenitally infected broiler chickens by an immunohistochemistry technique detecting gp85 viral glycoprotein...
  101. ncbi Localization of avian leukosis virus subgroup J in naturally infected chickens by RNA in situ hybridization
    N L Stedman
    Department of Veterinary Pathology, College of Veterinary Medicine, University of Georgia, Athens 30602-4875, USA
    Vet Pathol 38:649-56. 2001
    The novel subgroup J of avian leukosis virus (ALV-J) has emerged as a significant cause of myeloid neoplasia and weight suppression in broiler chickens...

Research Grants64

  1. SOMATIC CELL TRANSFER TO MODEL MEDULLOBLASTOMA IN MICE
    Daniel W Fults; Fiscal Year: 2010
    ..This experimental system uses a retroviral vector (RCAS) derived from avian leukosis virus and a transgenic mouse line that expresses the retrovirus receptor under control of the Nestin gene ..
  2. Oncogenes and oncogenic microRNAs in chicken tumors
    Karen L Beemon; Fiscal Year: 2010
    ..Recently, activation of TERT by avian leukosis virus (ALV) integration was observed in B-cell lymphomas in chickens...
  3. STRUCTURE AND REPLICATION OF HEPATITIS DELTA VIRUS
    John Taylor; Fiscal Year: 1991
    ..By high stringency hybridization the quail is free of DNA related to the reverse transcriptase of avian leukosis virus. However, with lowered stringency it has been possible to detect and clone in a lambda vector sequences ..
  4. STRUCTURE AND REPLICATION OF HEPATITIS DELTA VIRUS
    John Taylor; Fiscal Year: 1992
    ..By high stringency hybridization the quail is free of DNA related to the reverse transcriptase of avian leukosis virus. However, with lowered stringency it has been possible to detect and clone in a lambda vector sequences ..
  5. STRUCTURE AND REPLICATION OF HEPATITIS DELTA VIRUS
    John Taylor; Fiscal Year: 1990
    ..By high stringency hybridization the quail is free of DNA related to the reverse transcriptase of avian leukosis virus. However, with lowered stringency it has been possible to detect and clone in a lambda vector sequences ..
  6. REGULATION OF ALV EXPRESSION AND PATHOGENESIS
    M Ruddell; Fiscal Year: 1992
    ..b>Avian leukosis virus (ALV) induces bursal lymphoma in chickens, after integration of viral long terminal repeat (LTR) sequences ..
  7. MUTATIONAL AND PHYSICAL ANALYSIS OF THE MULV-E RECEPTOR
    Lorraine Albritton; Fiscal Year: 2001
    ..a motif that is similar to a critical component of the binding sites of the HIV receptor, the subgroup A avian leukosis virus receptor, and possibly of the gibbon ape/subgroup B feline leukemia virus receptor, suggesting that at ..
  8. MUTATIONAL AND PHYSICAL ANALYSIS OF THE MULV-E RECEPTOR
    Lorraine Albritton; Fiscal Year: 2000
    ..a motif that is similar to a critical component of the binding sites of the HIV receptor, the subgroup A avian leukosis virus receptor, and possibly of the gibbon ape/subgroup B feline leukemia virus receptor, suggesting that at ..
  9. MUTATIONAL AND PHYSICAL ANALYSIS OF THE MULV-E RECEPTOR
    Lorraine Albritton; Fiscal Year: 1999
    ..a motif that is similar to a critical component of the binding sites of the HIV receptor, the subgroup A avian leukosis virus receptor, and possibly of the gibbon ape/subgroup B feline leukemia virus receptor, suggesting that at ..
  10. Technology to Optimize scFvs for Targeting Therapeutics
    MARK FEDERSPIEL; Fiscal Year: 2005
    ..We have recently demonstrated the feasibility of a retrovirus, avian leukosis virus (ALV), as a viral platform for the display of a variety of eukaryotic polypeptides including scFvs, and the ..
  11. Technology to Optimize scFvs for Targeting Therapeutics
    MARK FEDERSPIEL; Fiscal Year: 2007
    ..We have recently demonstrated the feasibility of a retrovirus, avian leukosis virus (ALV), as a viral platform for the display of a variety of eukaryotic polypeptides including scFvs, and the ..
  12. Technology to Optimize scFvs for Targeting Therapeutics
    MARK FEDERSPIEL; Fiscal Year: 2006
    ..We have recently demonstrated the feasibility of a retrovirus, avian leukosis virus (ALV), as a viral platform for the display of a variety of eukaryotic polypeptides including scFvs, and the ..
  13. ONCOGENE ACTIVATION IN B AND T LYMPHOCYTES
    Hsing Jien Kung; Fiscal Year: 2000
    ..Avian B-lymphomas are frequently associated with infections by nonacute retroviruses, ALV (avian leukosis virus) and REV (reticuloendotheliosis virus)...
  14. ONCOGENE ACTIVATION IN AVIAN BAND T LYMPHOMA
    Hsing Jien Kung; Fiscal Year: 1993
    ..Avian B-lymphomas are frequently associated with infections by nonacute retroviruses, ALV (avian leukosis virus) and REV (reticuloendotheliosis virus)...
  15. SOMATIC CELL TRANSFER TO MODEL MEDULLOBLASTOMA IN MICE
    DANIEL FULTS; Fiscal Year: 2009
    ..This experimental system uses a retroviral vector (RCAS) derived from avian leukosis virus and a transgenic mouse line that expresses the retrovirus receptor under control of the Nestin gene ..
  16. ONCOGENE ACTIVATION IN B AND T LYMPHOCYTES
    Hsing Jien Kung; Fiscal Year: 1999
    ..Avian B-lymphomas are frequently associated with infections by nonacute retroviruses, ALV (avian leukosis virus) and REV (reticuloendotheliosis virus)...
  17. BIOCHEMISTRY OF RNA TUMOR VIRUS REPLICATION
    RALPH SMITH; Fiscal Year: 1990
    ..Macroscopic and microscopic fibrosarcomas induced by a recombinant avian leukosis virus will be characterized...
  18. RETROVIRUS-HOST INTERACTIONS
    Harriet Robinson; Fiscal Year: 1990
    ..ALV sequences in tissue tropism, the effect of thymotropism on immune response, and immune response to avian leukosis virus infections...
  19. Cell Biology of Retroviral Entry and Uncoating
    Walther Mothes; Fiscal Year: 2006
    ..The Avian Leukosis virus (ALV) and Murine Leukemia viruses (MLV) provide excellent model systems to study these processes...
  20. Cell Biology of Retroviral Entry and Uncoating
    Walther Mothes; Fiscal Year: 2007
    ..The Avian Leukosis virus (ALV) and Murine Leukemia viruses (MLV) provide excellent model systems to study these processes...
  21. Cell Biology of Retroviral Entry and Uncoating
    Walther Mothes; Fiscal Year: 2003
    ..The Avian Leukosis virus (ALV) and Murine Leukemia viruses (MLV) provide excellent model systems to study these processes...
  22. Cell Biology of Retroviral Entry and Uncoating
    Walther Mothes; Fiscal Year: 2004
    ..The Avian Leukosis virus (ALV) and Murine Leukemia viruses (MLV) provide excellent model systems to study these processes...
  23. Cell Biology of Retroviral Entry and Uncoating
    Walther Mothes; Fiscal Year: 2005
    ..The Avian Leukosis virus (ALV) and Murine Leukemia viruses (MLV) provide excellent model systems to study these processes...
  24. Novel Animal Model System of AIDS-Kaposi Sarcoma
    Patricio Ray; Fiscal Year: 2004
    ..We will generate a dual Tg mouse model expressing HIV-tat and the avian leukosis virus (ALV)-receptor, TVA, both under the control of the EC-specific TIE2 promoter...
  25. Novel Animal Model System of AIDS-Kaposi Sarcoma
    Patricio Ray; Fiscal Year: 2005
    ..We will generate a dual Tg mouse model expressing HIV-tat and the avian leukosis virus (ALV)-receptor, TVA, both under the control of the EC-specific TIE2 promoter...
  26. WORKSHOP ON PATHOGENESIS BY NON-ACUTE RETROVIRUSES
    Hung Fan; Fiscal Year: 1992
    ..Viruses to be considered include murine leukemia viruses, avian leukosis virus, feline leukemia virus, murine mammary tumor virus, HTLV-I, bovine leukemia virus, MAIDS virus, and non-..
  27. AVIAN ERYTHROLEUKEMIA AND C-ERBB ACTIVATION
    Hsing Jien Kung; Fiscal Year: 1990
    b>Avian leukosis virus (ALV) is the prototype of non-acute retroviruses, a group of naturally occurring cancer viruses which do not carry oncogenes and induce cancers by proviral insertional activation of host oncogenes...
  28. MOLECULAR MECHANISMS OF TPO INDUCED MPL SIGNALING IN MEGAKARYOCYTES
    ANDREW LEAVITT; Fiscal Year: 2004
    ..We recently developed transgenic mice with avian leukosis virus receptor (TVA) expression restricted to cells of the megakaryocyte lineage...
  29. SOMATIC CELL TRANSFER TO MODEL MEDULLOBLASTOMA IN MICE
    DANIEL FULTS; Fiscal Year: 2006
    ..This system utilizes a retroviral vector (RCAS), derived from avian leukosis virus, subgroup A (ALV-A), and a transgenic mouse line (Ntv-a) that expresses TVA (the receptor for ALV-A) under ..
  30. SOMATIC CELL TRANSFER TO MODEL MEDULLOBLASTOMA IN MICE
    DANIEL FULTS; Fiscal Year: 2005
    ..This system utilizes a retroviral vector (RCAS), derived from avian leukosis virus, subgroup A (ALV-A), and a transgenic mouse line (Ntv-a) that expresses TVA (the receptor for ALV-A) under ..
  31. SOMATIC CELL TRANSFER TO MODEL MEDULLOBLASTOMA IN MICE
    DANIEL FULTS; Fiscal Year: 2007
    ..This system utilizes a retroviral vector (RCAS), derived from avian leukosis virus, subgroup A (ALV-A), and a transgenic mouse line (Ntv-a) that expresses TVA (the receptor for ALV-A) under ..
  32. CHARACTERIZING THE MECHANISMS OF ALSV ENTRY INTO CELLS
    John Young; Fiscal Year: 2003
    ..This proposal is aimed at better understanding this critical first step of viral replication using the avian leukosis virus (ALV)-receptor model system...
  33. CHARACTERIZING THE MECHANISMS OF ALSV ENTRY INTO CELLS
    John Young; Fiscal Year: 2002
    ..This proposal is aimed at better understanding this critical first step of viral replication using the avian leukosis virus (ALV)-receptor model system...
  34. CHARACTERIZING THE MECHANISMS OF ALSV ENTRY INTO CELLS
    John Young; Fiscal Year: 2001
    ..This proposal is aimed at better understanding this critical first step of viral replication using the avian leukosis virus (ALV)-receptor model system...
  35. Oncogenes and oncogenic microRNAs in chicken tumors
    Karen Beemon; Fiscal Year: 2009
    ..Recently, activation of TERT by avian leukosis virus (ALV) integration was observed in B-cell lymphomas in chickens...
  36. CHARACTERIZING THE MECHANISMS OF ALSV ENTRY INTO CELLS
    John Young; Fiscal Year: 2000
    ..This proposal is aimed at better understanding this critical first step of viral replication using the avian leukosis virus (ALV)-receptor model system...
  37. CHARACTERIZING THE MECHANISMS OF ALSV ENTRY INTO CELLS
    John Young; Fiscal Year: 2004
    ..This proposal is aimed at better understanding this critical first step of viral replication using the avian leukosis virus (ALV)-receptor model system...
  38. CHARACTERIZING THE MECHANISMS OF ALSV ENTRY INTO CELLS
    John Young; Fiscal Year: 2003
    ..This proposal is aimed at better understanding this critical first step of viral replication using the avian leukosis virus (ALV)-receptor model system...
  39. MECHANISMS OF CELL KILLING INDUCED BY RETROVIRUSES
    John Young; Fiscal Year: 2003
    ..These studies focus on the avian leukosis virus-B (ALV), whose receptor, TVB, is a functional death receptor in the TNFR-family...
  40. MECHANISMS OF CELL KILLING INDUCED BY RETROVIRUSES
    John Young; Fiscal Year: 1999
    ..These studies focus on the avian leukosis virus-B (ALV), whose receptor, TVB, is a functional death receptor in the TNFR-family...
  41. MECHANISMS OF CELL KILLING INDUCED BY RETROVIRUSES
    John Young; Fiscal Year: 2001
    ..These studies focus on the avian leukosis virus-B (ALV), whose receptor, TVB, is a functional death receptor in the TNFR-family...
  42. MECHANISMS OF CELL KILLING INDUCED BY RETROVIRUSES
    John Young; Fiscal Year: 2002
    ..These studies focus on the avian leukosis virus-B (ALV), whose receptor, TVB, is a functional death receptor in the TNFR-family...
  43. MECHANISMS OF CELL KILLING INDUCED BY RETROVIRUSES
    John Young; Fiscal Year: 1999
    ..These studies focus on the avian leukosis virus-B (ALV), whose receptor, TVB, is a functional death receptor in the TNFR-family...
  44. MECHANISMS OF CELL KILLING INDUCED BY RETROVIRUSES
    John Young; Fiscal Year: 2003
    ..These studies focus on the avian leukosis virus-B (ALV), whose receptor, TVB, is a functional death receptor in the TNFR-family...
  45. MECHANISMS OF CELL KILLING INDUCED BY RETROVIRUSES
    John Young; Fiscal Year: 2000
    ..These studies focus on the avian leukosis virus-B (ALV), whose receptor, TVB, is a functional death receptor in the TNFR-family...
  46. RECOMBINANT PHARMACEUTICAL PROTEIN PRODUCTION IN EGGS
    Clague Hodgson; Fiscal Year: 1990
    ..The avian leukosis virus replicative element will be combined with a second transcriptional unit consisting of the steroid hormone-..
  47. RECOMBINANT PHARMACETICAL PROTEIN PRODUCTION IN EGGS
    Clague Hodgson; Fiscal Year: 1993
    ..The avian leukosis virus replicative element will be combined with a second transcriptional unit consisting of the steroid hormone-..
  48. Cell Type-Specific Gene Delivery in Mammalian Retina
    Vijay Sarthy; Fiscal Year: 2007
    ..The present proposal describes a cell targeting strategy based on the use of the receptor for subgroup-A avian leukosis virus, TVA, to target retroviral vectors carrying genes of interest to a specific cell type in the mouse retina...
  49. Cell Type-Specific Gene Delivery in Mammalian Retina
    Vijay Sarthy; Fiscal Year: 2006
    ..The present proposal describes a cell targeting strategy based on the use of the receptor for subgroup-A avian leukosis virus, TVA, to target retroviral vectors carrying genes of interest to a specific cell type in the mouse retina...
  50. Cell Type-Specific Gene Delivery in Mammalian Retina
    Vijay Sarthy; Fiscal Year: 2005
    ..The present proposal describes a cell targeting strategy based on the use of the receptor for subgroup-A avian leukosis virus, TVA, to target retroviral vectors carrying genes of interest to a specific cell type in the mouse retina...
  51. C MYC EXPRESSION DURING ALV LYMPHOMAGENESIS
    M Ruddell; Fiscal Year: 2000
    DESCRIPTION: (Adapted from the investigator's abstract) Avian leukosis virus (ALV) rapidly induces metastatic bursal lymphomas in lymphoma-susceptible chicken strains, after clonal expansion of B cells harboring a proviral c-myc gene ..
  52. C MYC EXPRESSION DURING ALV LYMPHOMAGENESIS
    M Ruddell; Fiscal Year: 2001
    DESCRIPTION: (Adapted from the investigator's abstract) Avian leukosis virus (ALV) rapidly induces metastatic bursal lymphomas in lymphoma-susceptible chicken strains, after clonal expansion of B cells harboring a proviral c-myc gene ..
  53. C MYC EXPRESSION DURING ALV LYMPHOMAGENESIS
    M Ruddell; Fiscal Year: 2002
    DESCRIPTION: (Adapted from the investigator's abstract) Avian leukosis virus (ALV) rapidly induces metastatic bursal lymphomas in lymphoma-susceptible chicken strains, after clonal expansion of B cells harboring a proviral c-myc gene ..
  54. C MYC EXPRESSION DURING ALV LYMPHOMAGENESIS
    M Ruddell; Fiscal Year: 2003
    DESCRIPTION: (Adapted from the investigator's abstract) Avian leukosis virus (ALV) rapidly induces metastatic bursal lymphomas in lymphoma-susceptible chicken strains, after clonal expansion of B cells harboring a proviral c-myc gene ..
  55. C MYC EXPRESSION DURING ALV LYMPHOMAGENESIS
    M Ruddell; Fiscal Year: 2004
    DESCRIPTION: (Adapted from the investigator's abstract) Avian leukosis virus (ALV) rapidly induces metastatic bursal lymphomas in lymphoma-susceptible chicken strains, after clonal expansion of B cells harboring a proviral c-myc gene ..
  56. CHARACTERIZATION OF THE ALV-INDUCED TRANSFORMED FOLLICLE
    ERIC HUMPHRIES; Fiscal Year: 1990
    b>Avian leukosis virus induces a bursal dependent B cell lymphoma in the chicken. A rare histopathological lesion, the transformed follicle, appears in the bursa shortly after infection...
  57. MOUSE MODELS OF HUMAN BREAST CANCER
    Jeffrey Rosen; Fiscal Year: 2006
    ..Sca-1+ progenitor cells by a knock-in of the reverse tetracycline-responsive transactivator (rtTA) and the avian leukosis virus TVA receptor into the Sca-1 locus...
  58. MOUSE MODELS OF HUMAN BREAST CANCER
    Jeffrey Rosen; Fiscal Year: 2007
    ..progenitor cells by a knock-in of the reverse tetracycline-responsive transactivator (rtTA) and the avian leukosis virus TVA receptor into the Sca-1 locus...
  59. MOUSE MODELS OF HUMAN BREAST CANCER
    Jeffrey Rosen; Fiscal Year: 2007
    ..Sca-1+ progenitor cells by a knock-in of the reverse tetracycline-responsive transactivator (rtTA) and the avian leukosis virus TVA receptor into the Sca-1 locus...