vesiculovirus

Summary

Summary: A genus of the family RHABDOVIRIDAE that infects a wide range of vertebrates and invertebrates. The type species is VESICULAR STOMATITIS-INDIANA VIRUS.

Top Publications

  1. ncbi Chandipura virus: an emerging human pathogen?
    Marc Van Ranst
    Rega Institute for Medical Research, University of Leuven, Leuven, BE 3000, Belgium
    Lancet 364:821-2. 2004
  2. ncbi A large outbreak of acute encephalitis with high fatality rate in children in Andhra Pradesh, India, in 2003, associated with Chandipura virus
    B L Rao
    National Institute of Virology, Pune, India
    Lancet 364:869-74. 2004
  3. ncbi Complete genome sequences of Chandipura and Isfahan vesiculoviruses
    A C Marriott
    Department of Biological Sciences, University of Warwick, Coventry, UK
    Arch Virol 150:671-80. 2005
  4. ncbi Immune synapses formed with measles virus-infected dendritic cells are unstable and fail to sustain T cell activation
    Yoanna Shishkova
    University of Wurzburg, Institute for Virology and Immunobiology, Versbacher Street 7, D 97078 Wurzburg, Germany
    Cell Microbiol 9:1974-86. 2007
  5. ncbi Reviewing Chandipura: a vesiculovirus in human epidemics
    Soumen Basak
    Department of Chemistry and Biochemistry, Signaling Systems Laboratory, University of California, San Diego, CA 92093, USA
    Biosci Rep 27:275-98. 2007
  6. pmc Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid-inducible gene-I and melanoma differentiation-associated gene 5
    Hiroki Kato
    Laboratory of Host Defense, World Premiere International Immunology Frontier Research Center, Osaka University, Suita, Osaka 565 0871, Japan
    J Exp Med 205:1601-10. 2008
  7. pmc Host cell factors and functions involved in vesicular stomatitis virus entry
    Hrefna Kristin Johannsdottir
    Institute of Biochemistry, ETH Zurich, Schafmattstrasse 18, CH 8093 Zurich, Switzerland
    J Virol 83:440-53. 2009
  8. doi Local type I IFN receptor signaling protects against virus spread within the central nervous system
    Claudia N Detje
    Division of Immunology, Paul Ehrlich Institut, Langen, Germany
    J Immunol 182:2297-304. 2009
  9. ncbi Chandipura virus encephalitis outbreak among children in Nagpur division, Maharashtra, 2007
    Yogesh K Gurav
    National Institute of Virology ICMR, Pune, India
    Indian J Med Res 132:395-9. 2010
  10. ncbi Initiation of encapsidation as evidenced by deoxycholate-treated Nucleocapsid protein in the Chandipura virus life cycle
    Raja Bhattacharya
    Dr B C Guha Centre for Genetic Engineering and Biotechnology, Department of Biochemistry, University College of Science, University of Calcutta, Calcutta 700 019, India
    Virology 349:197-211. 2006

Research Grants

  1. QUALITATIVE NATURE OF ANTIBODIES TO HCV GLYCOPROTEIN SUBUNIT VACCINE IN HUMANS
    Ranjit Ray; Fiscal Year: 2007
  2. IMMUNE RESPONSES TO VSV/HIV/SIV HYBRIDS IN MACAQUES
    John Rose; Fiscal Year: 2002
  3. GABA-EXCITATORY TRANSMITTER IN DEVELOPING HYPOTHALAMUS
    Anthony van den Pol; Fiscal Year: 2002
  4. DETERMINANTS OF AXON LENGTH FOLLOWING INJURY
    Anthony van den Pol; Fiscal Year: 2002
  5. NPY DEPRESSION OF HIPPOCAMPAL EPILEPSY
    Anthony van den Pol; Fiscal Year: 2002
  6. GABA: EXCITATORY TRANSMITTER IN DEVELOPING HYPOTHALAMUS
    Anthony van den Pol; Fiscal Year: 2007
  7. Hypocretin Neurons
    Anthony van den Pol; Fiscal Year: 2006
  8. Hypocretin Neurons
    Anthony van den Pol; Fiscal Year: 2007
  9. Cytomegalovirus in the Brain
    Anthony van den Pol; Fiscal Year: 2005
  10. Oncolytic Virus Targets Brain Tumors
    Anthony van den Pol; Fiscal Year: 2007

Detail Information

Publications182 found, 100 shown here

  1. ncbi Chandipura virus: an emerging human pathogen?
    Marc Van Ranst
    Rega Institute for Medical Research, University of Leuven, Leuven, BE 3000, Belgium
    Lancet 364:821-2. 2004
  2. ncbi A large outbreak of acute encephalitis with high fatality rate in children in Andhra Pradesh, India, in 2003, associated with Chandipura virus
    B L Rao
    National Institute of Virology, Pune, India
    Lancet 364:869-74. 2004
    ..An outbreak of acute encephalitis of unknown origin with high case fatality (183 of 329 cases) was reported in children from Andhra Pradesh state in southern India during 2003. We investigated the causative agent...
  3. ncbi Complete genome sequences of Chandipura and Isfahan vesiculoviruses
    A C Marriott
    Department of Biological Sciences, University of Warwick, Coventry, UK
    Arch Virol 150:671-80. 2005
    Chandipura virus (CHPV) and Isfahan virus (ISFV) are two members of the genus Vesiculovirus from Asia. Both are arthropod-transmitted and are able to infect humans, but neither causes vesicular stomatitis in livestock...
  4. ncbi Immune synapses formed with measles virus-infected dendritic cells are unstable and fail to sustain T cell activation
    Yoanna Shishkova
    University of Wurzburg, Institute for Virology and Immunobiology, Versbacher Street 7, D 97078 Wurzburg, Germany
    Cell Microbiol 9:1974-86. 2007
    ....
  5. ncbi Reviewing Chandipura: a vesiculovirus in human epidemics
    Soumen Basak
    Department of Chemistry and Biochemistry, Signaling Systems Laboratory, University of California, San Diego, CA 92093, USA
    Biosci Rep 27:275-98. 2007
    Chandipura virus, a member of the rhabdoviridae family and vesiculovirus genera, has recently emerged as human pathogen that is associated with a number of outbreaks in different parts of India...
  6. pmc Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid-inducible gene-I and melanoma differentiation-associated gene 5
    Hiroki Kato
    Laboratory of Host Defense, World Premiere International Immunology Frontier Research Center, Osaka University, Suita, Osaka 565 0871, Japan
    J Exp Med 205:1601-10. 2008
    ..Collectively, RIG-I detects dsRNAs without a 5'-triphosphate end, and RIG-I and MDA5 selectively recognize short and long dsRNAs, respectively...
  7. pmc Host cell factors and functions involved in vesicular stomatitis virus entry
    Hrefna Kristin Johannsdottir
    Institute of Biochemistry, ETH Zurich, Schafmattstrasse 18, CH 8093 Zurich, Switzerland
    J Virol 83:440-53. 2009
    ..Dynamin-2 was recruited to plasma membrane-confined virus particles. Thus, VSV can induce productive internalization by exploiting a specific combination of the clathrin-associated proteins and cellular functions...
  8. doi Local type I IFN receptor signaling protects against virus spread within the central nervous system
    Claudia N Detje
    Division of Immunology, Paul Ehrlich Institut, Langen, Germany
    J Immunol 182:2297-304. 2009
    ..Our data indicate that upon intranasal VSV instillation, early and localized IFNAR triggering in the glomerular layer of the olfactory bulb is critically required to prevent viral spread over the entire CNS and thus confers survival...
  9. ncbi Chandipura virus encephalitis outbreak among children in Nagpur division, Maharashtra, 2007
    Yogesh K Gurav
    National Institute of Virology ICMR, Pune, India
    Indian J Med Res 132:395-9. 2010
    ..An outbreak of acute encephalitis syndrome (AES) among children from Nagpur division, Maharashtra was investigated to confirm the aetiology and to describe clinico-epidemiological features...
  10. ncbi Initiation of encapsidation as evidenced by deoxycholate-treated Nucleocapsid protein in the Chandipura virus life cycle
    Raja Bhattacharya
    Dr B C Guha Centre for Genetic Engineering and Biotechnology, Department of Biochemistry, University College of Science, University of Calcutta, Calcutta 700 019, India
    Virology 349:197-211. 2006
    ..Based on our observations, we propose a model to explain encapsidation that involves two discrete biochemically separable steps, initiation and elongation...
  11. pmc Structure of the vesicular stomatitis virus N⁰-P complex
    Cédric Leyrat
    UMI 3265 UJF EMBL CNRS Unit of Virus Host Cell Interactions, Grenoble, France
    PLoS Pathog 7:e1002248. 2011
    ..The structure of this complex also suggests a mechanism for the initiation of viral RNA synthesis...
  12. doi Management of accidental exposure to Ebola virus in the biosafety level 4 laboratory, Hamburg, Germany
    Stephan Gunther
    Department of Virology, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany
    J Infect Dis 204:S785-90. 2011
    ..Otherwise, the person remained healthy, and ZEBOV RNA, except for the glycoprotein gene expressed in the vaccine, was never detected in serum and peripheral blood mononuclear cells during the 3-week observation period...
  13. ncbi Requirement for cyclophilin A for the replication of vesicular stomatitis virus New Jersey serotype
    Santanu Bose
    Department of Virology, Lerner Research Institute, Room NN 10, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    J Gen Virol 84:1687-99. 2003
    ..The different requirements for CypA by two serologically different viruses belonging to the same family has highlighted the utilization of specific host factors during their evolutionary lineages...
  14. ncbi Assessment of a vesicular stomatitis virus-based vaccine by use of the mouse model of Ebola virus hemorrhagic fever
    Steven M Jones
    Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Canada
    J Infect Dis 196:S404-12. 2007
    ..In the present study, we used the mouse model for Ebola hemorrhagic fever to assess the safety and efficacy of a vaccine based on a live attenuated vesicular stomatitis virus expressing the Zaire ebolavirus (ZEBOV) glycoprotein...
  15. pmc Rho GTPases modulate entry of Ebola virus and vesicular stomatitis virus pseudotyped vectors
    Kathrina Quinn
    Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Virol 83:10176-86. 2009
    ..In total, our studies implicate RhoB and RhoC in enhanced productive entry of some pseudovirions and suggest the involvement of actin-mediated macropinocytosis as a mechanism of uptake of EBOV GP and VSVG pseudotyped viral particles...
  16. pmc The cytoplasmic location of chicken mx is not the determining factor for its lack of antiviral activity
    Camilla T O Benfield
    Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom
    PLoS ONE 5:e12151. 2010
    ..We also report the consequences of re-locating chicken Mx to the nucleus...
  17. doi Regulation of interferon production and innate antiviral immunity through translational control of IRF-7
    Andrea K Erickson
    Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX, 75235 9840, USA
    Cell Res 18:433-5. 2008
  18. pmc CK2 inhibitors increase the sensitivity of HSV-1 to interferon-β
    Miles C Smith
    Department of Molecular Biosciences, University of Kansas, Lawrence, KS 66045, USA
    Antiviral Res 91:259-66. 2011
    ..Thus, our data suggest that the activity of CK2 is required for an early function during viral infection that assists the growth of HSV-1 in IFN-β-treated cells...
  19. pmc The matrix protein of vesicular stomatitis virus binds dynamin for efficient viral assembly
    Hélène Raux
    Centre de Recherche de Gif, Laboratoire de Virologie Moleculaire et Structurale, CNRS UPR 3296, IFR115, Allée de la Terrasse, 91198, Gif sur Yvette, France
    J Virol 84:12609-18. 2010
    ..Finally, we showed that M-dynamin interaction affects clathrin-dependent endocytosis. Our study suggests that hijacking the endocytic pathway might be an important feature for enveloped virus assembly and budding at the plasma membrane...
  20. doi Phenotypes of vesicular stomatitis virus mutants with mutations in the PSAP motif of the matrix protein
    Linda Obiang
    Centre de Recherche de Gif, Laboratoire de Virologie Moleculaire et Structurale, CNRS UPR 3296, 91198 Gif sur Yvette Cedex, France
    J Gen Virol 93:857-65. 2012
    ..These results have implications for the VSV budding pathway that will be discussed...
  21. pmc CD4+ T cell regulation of CD25 expression controls development of short-lived effector CD8+ T cells in primary and secondary responses
    Joshua J Obar
    Department of Immunology, University of Connecticut Health Center, Farmington CT 06030, USA
    Proc Natl Acad Sci U S A 107:193-8. 2010
    ....
  22. pmc The HR motif in the RNA-dependent RNA polymerase L protein of Chandipura virus is required for unconventional mRNA-capping activity
    Tomoaki Ogino
    Department of Molecular Genetics, Section of Virology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    J Gen Virol 91:1311-4. 2010
    ..These results suggest that the rhabdoviral L proteins universally use the active-site HR motif for the PRNTase reaction at the step of the enzyme-pRNA intermediate formation...
  23. doi Fusion-active glycoprotein G mediates the cytotoxicity of vesicular stomatitis virus M mutants lacking host shut-off activity
    Markus Hoffmann
    Institut fur Virologie, Stiftung Tierarztliche Hochschule Hannover, Hannover, Germany
    J Gen Virol 91:2782-93. 2010
    ..These findings indicate that the host shut-off activity of the M protein dominates VSV cytotoxicty, whilst the fusion-active G protein is mainly responsible for the cytotoxicity remaining with M-mutant VSV...
  24. pmc Ubiquitin depletion and dominant-negative VPS4 inhibit rhabdovirus budding without affecting alphavirus budding
    Gwen M Taylor
    Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Virol 81:13631-9. 2007
    ..In contrast, SFV budding was independent of both ubiquitin and the activity of VPS4, perhaps reflecting the important role of the highly organized envelope protein lattice during alphavirus budding...
  25. pmc Access to RNA encapsidated in the nucleocapsid of vesicular stomatitis virus
    Todd J Green
    Department of Microbiology, University of Alabama at Birmingham, 1025 18th Street South, Birmingham, AL 35294, USA
    J Virol 85:2714-22. 2011
    ..Polyribonucleotides were reencapsidated into the empty NLP, and the crystal structures were determined. The crystal structures revealed variable degrees of association of the N protein with a specific RNA sequence...
  26. pmc The N(0)-binding region of the vesicular stomatitis virus phosphoprotein is globally disordered but contains transient α-helices
    Cédric Leyrat
    Unit of Virus Host Cell Interactions, UMI 3265 UJF EMBL CNRS, 38042 Grenoble Cedex 9, France
    Protein Sci 20:542-56. 2011
    ..Our results are interpreted in the context of a scenario whereby VSV P(NTR) constitutes a molecular recognition element undergoing a disorder-to-order transition upon binding to its partner when forming the N(0)-P complex...
  27. doi Recombinant vesicular stomatitis virus-based west Nile vaccine elicits strong humoral and cellular immune responses and protects mice against lethal challenge with the virulent west Nile virus strain LSU-AR01
    Arun V Iyer
    Louisiana State University School of Veterinary Medicine, Baton Rouge, LA 70803, USA
    Vaccine 27:893-903. 2009
    ..These results suggest that VSV-vectored vaccines administered intranasally can efficiently induce protective humoral and cellular immune responses against WNV infections...
  28. doi Systemic vesicular stomatitis virus selectively destroys multifocal glioma and metastatic carcinoma in brain
    Koray Ozduman
    Department of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Neurosci 28:1882-93. 2008
    ..Quantitative PCR analysis of how VSVrp30a selectively infected tumor cells suggested multiple mechanisms, including cell surface binding and internalization...
  29. pmc Interaction of vesicular stomatitis virus P and N proteins: identification of two overlapping domains at the N terminus of P that are involved in N0-P complex formation and encapsidation of viral genome RNA
    Mingzhou Chen
    Department of Molecular Genetics, Section of Virology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Virol 81:13478-85. 2007
    ..Taking these results together, we conclude that the N-terminal 11 to 30 aa are required for N(0)-P complex formation but the N-terminal 210 aa are required for genome RNA encapsidation...
  30. pmc Vesicular stomatitis virus oncolysis is potentiated by impairing mTORC1-dependent type I IFN production
    Tommy Alain
    Department of Biochemistry and Goodman Cancer Center, McGill University, Montreal, QC H3G 1Y6, Canada
    Proc Natl Acad Sci U S A 107:1576-81. 2010
    ..These results demonstrate that reducing type I IFNs through inhibition of mTORC1 is an effective strategy to augment the therapeutic activity of VSV(DeltaM51)...
  31. pmc Viral mutagenesis as a means for generating novel proteins
    John N Davis
    Department of Neurosurgery, Yale University School of Medicine, 333 Cedar St, New Haven, CT 06520, USA
    J Virol 84:1625-30. 2010
    ..Similar methods may be useful in the development of physiologically sensitive fluorescent reporter proteins and directed evolution or mutagenesis of proteins in general...
  32. pmc Internalization of swine vesicular disease virus into cultured cells: a comparative study with foot-and-mouth disease virus
    Miguel A Martín-Acebes
    Centro de Biologia Molecular Severo Ochoa CSIC UAM, Cantoblanco, Madrid, Spain
    J Virol 83:4216-26. 2009
    ..These results suggest that different clathrin-mediated routes are responsible for the internalization of these viruses...
  33. ncbi Chandipura virus, encephalitis, and epidemic brain attack in India
    T Jacob John
    Lancet 364:2175; author reply 2175-6. 2004
  34. doi Characterization of the full-length genomic sequences of vesicular stomatitis Cocal and Alagoas viruses
    Steven J Pauszek
    Plum Island Animal Disease Center, Agricultural Research Service, US Department of Agriculture, Orient Point, Long Island, P O Box 848, Greenport, NY 11944 0848, USA
    Arch Virol 153:1353-7. 2008
    ..Phylogenetic analyses consistently grouped COCV, VSAV and VSIV in a monophyletic group distinct from VSNJV, supporting the classification of these viruses within the Indiana serogroup...
  35. pmc Glycoprotein-dependent acidification of vesicular stomatitis virus enhances release of matrix protein
    Chad E Mire
    Department of Molecular Sciences, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    J Virol 83:12139-50. 2009
    ..From these data we propose that low-pH conformational changes in G protein promote acidification of the virus interior, which facilitates the release of M from ribonucleoprotein particles during uncoating...
  36. doi The protease-sensitive loop of the vesicular stomatitis virus matrix protein is involved in virus assembly and protein translation
    Chad E Mire
    Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Virology 416:16-25. 2011
    ..These results indicate that the LXD motif is involved in both virus assembly and VSV protein translation...
  37. ncbi Black fly involvement in the epidemic transmission of vesicular stomatitis New Jersey virus (Rhabdoviridae: Vesiculovirus)
    Daniel G Mead
    Southeastern Cooperative Wildlife Disease Study, University of Georgia, Athens, Georgia 30602, USA
    Vector Borne Zoonotic Dis 4:351-9. 2004
    ....
  38. ncbi BrainStem encephalitis associated with chandipura in Andhra Pradesh outbreak
    S Narasimha Rao
    Government Institute of Child Health, Niloufer Hospital, Red Hills, Hyderabad 500004, India
    J Trop Pediatr 54:25-30. 2008
    ..Evidence of Chandipura virus was detected in these cases as the etiological agent...
  39. ncbi P-protein of Chandipura virus is an N-protein-specific chaperone that acts at the nucleation stage
    Amitabha Majumdar
    Dr B C Guha Centre for Genetic Engineering and Biotechnology, Department of Biochemistry, University College of Science, University of Calcutta, 35 Ballygunge Circular Road, Calcutta 700 019, India
    Biochemistry 43:2863-70. 2004
    ..The P-protein is thus an N-protein-specific chaperone which inhibits the nucleation phase of N-protein aggregation, thus keeping a pool of encapsidation-competent N-protein for viral maturation...
  40. ncbi Chandipura virus growth kinetics in vertebrate cell lines, insect cell lines & embryonated eggs
    R S Jadi
    Microbial Containment Complex, National Institute of Virology ICMR, Pune, India
    Indian J Med Res 132:155-9. 2010
    ..Since not much information on Chandipura virus is available, an attempt was made to study the growth kinetics of the virus in certain vertebrate, invertebrate cell lines and embryonated chicken eggs...
  41. doi Elucidation of functional domains of Chandipura virus Nucleocapsid protein involved in oligomerization and RNA binding: implication in viral genome encapsidation
    Arindam Mondal
    Department of Biochemistry, University of Calcutta, Kolkata, India
    Virology 407:33-42. 2010
    Chandipura virus, a member of the vesiculovirus genera, has been recently recognized as an emerging human pathogen...
  42. doi Characterization of the complete genome sequence of pike fry rhabdovirus
    Hong Lian Chen
    College of Fisheries, Huazhong Agriculture University, 430070, Wuhan, People s Republic of China
    Arch Virol 154:1489-94. 2009
    ..3 to 91.4%. Phylogenetic analysis of the five proteins showed that PFRV clusters with SVCV and is closely related to the mammalian vesiculoviruses, 903/87, STRV and SCRV...
  43. pmc Recombinant vesicular stomatitis virus vector mediates postexposure protection against Sudan Ebola hemorrhagic fever in nonhuman primates
    Thomas W Geisbert
    National Emerging Infectious Diseases Laboratories Institute, Boston, Massachusetts, USA
    J Virol 82:5664-8. 2008
    ..This is the first demonstration of complete postexposure protection against an Ebola virus in nonhuman primates and provides further evidence that postexposure vaccination may have utility in treating exposures to filoviruses...
  44. doi Direct priming of antiviral CD8+ T cells in the peripheral interfollicular region of lymph nodes
    Heather D Hickman
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA
    Nat Immunol 9:155-65. 2008
    ..Thus, antigen presentation at the lymph node periphery, not at lymphocyte exit sites in deeper lymph node venules, as dogma dictates, has a dominant function in antiviral CD8+ T cell activation...
  45. pmc Molecular architecture of the vesicular stomatitis virus RNA polymerase
    Amal A Rahmeh
    Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston MA 02115, USA
    Proc Natl Acad Sci U S A 107:20075-80. 2010
    ..Because the arrangement of conserved regions involved in catalysis is homologous, the structural insights obtained for VSV L likely extend to all NNS RNA viruses...
  46. pmc Vesicular stomatitis virus enters cells through vesicles incompletely coated with clathrin that depend upon actin for internalization
    David K Cureton
    Departments of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Pathog 5:e1000394. 2009
    ..This work provides new mechanistic insights into the process of virus internalization as well as uptake of unconventional cargo by the clathrin-dependent endocytic machinery...
  47. doi Evolutionary genomics of host adaptation in vesicular stomatitis virus
    Susanna K Remold
    Department of Biology, University of Louisville, USA
    Mol Biol Evol 25:1138-47. 2008
    ..We discuss the degree to which current genetic architecture is expected to constrain future evolution of complex traits, such as host use by RNA viruses...
  48. pmc Role of intermolecular interactions of vesicular stomatitis virus nucleoprotein in RNA encapsidation
    Xin Zhang
    Department of Microbiology, University of Alabama at Birmingham, 1025 18th Street South, Birmingham, AL 35294, USA
    J Virol 82:674-82. 2008
    ..These results suggest that the intermolecular contacts among the N molecules are required for encapsidation of the viral RNA...
  49. pmc A conserved motif in region v of the large polymerase proteins of nonsegmented negative-sense RNA viruses that is essential for mRNA capping
    Jianrong Li
    Department of Microbiology and Molecular Genetics, Harvard Medical School, 200 Longwood Ave, Boston, MA 02115, USA
    J Virol 82:775-84. 2008
    ....
  50. pmc Conserved characteristics of the rhabdovirus nucleoprotein
    Ming Luo
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Virus Res 129:246-51. 2007
    ..This may explain how the RNP can adopt different conformations from being packed as a superhelix in the virion to a relaxed linear structure once being delivered into the cytoplasm...
  51. pmc Histidine-mediated RNA transfer to GDP for unique mRNA capping by vesicular stomatitis virus RNA polymerase
    Tomoaki Ogino
    Department of Molecular Genetics, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Proc Natl Acad Sci U S A 107:3463-8. 2010
    ....
  52. pmc Single-amino-acid alterations in a highly conserved central region of vesicular stomatitis virus N protein differentially affect the viral nucleocapsid template functions
    Debasis Nayak
    Department of Veterinary and Biomedical Sciences and Nebraska Center for Virology, University of Nebraska Lincoln, Lincoln, Nebraska 68583 0900, USA
    J Virol 83:5525-34. 2009
    ..These results suggest that the structure of the N protein and the resulting N-RNA complex, in part, regulate the viral template functions in transcription and replication...
  53. pmc Vesicular stomatitis virus mRNA capping machinery requires specific cis-acting signals in the RNA
    Jennifer T Wang
    Department of Microbiology and Molecular Genetics, Harvard Medical School, 200 Longwood Ave, Boston, MA 02115, USA
    J Virol 81:11499-506. 2007
    ..These studies provide genetic and biochemical evidence that the mRNA capping apparatus of VSV evolved an RNA capping machinery that functions in a sequence-specific manner...
  54. pmc Recombinant vesicular stomatitis virus expressing influenza nucleoprotein induces CD8 T-cell responses that enhance antibody-mediated protection after lethal challenge with influenza virus
    Brice E Barefoot
    Duke University Human Vaccine Institute, Department of Medicine, Duke University School of Medicine, Durham, North Carolina 27710, USA
    Clin Vaccine Immunol 16:488-98. 2009
    ..Influenza NP is a highly conserved antigen, and induction of protective anti-NP responses may be a productive strategy for generating heterologous protection against divergent influenza strains...
  55. doi The ESCRT-I subunit TSG101 controls endosome-to-cytosol release of viral RNA
    Pierre Philippe Luyet
    Department of Biochemistry, University of Geneva, 30 quai E Ansermet, 1211 Geneva 4, Switzerland
    Traffic 9:2279-90. 2008
    ..We conclude that Tsg101, through selective interactions with its partners including Hrs and Alix, may link receptor sorting and lysosome targeting to the back-fusion process involved in viral capsid release...
  56. pmc S-adenosyl homocysteine-induced hyperpolyadenylation of vesicular stomatitis virus mRNA requires the methyltransferase activity of L protein
    Summer E Galloway
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, USA
    J Virol 82:12280-90. 2008
    ..Further, the data presented here show that the wild-type L protein hyperpolyadenylates a percentage of VSV mRNAs in infected cells as well as in vitro...
  57. doi In vitro antiviral activity of dehydroepiandrosterone and its synthetic derivatives against vesicular stomatitis virus
    Carina Romanutti
    Laboratorio de Virologia, Departamento de Quimica Biologica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pabellon 2, Piso 4, C1428EGA, Buenos Aires, Argentina
    Vet J 182:327-35. 2009
    ..Analysis of RNA and protein synthesis indicated that DHEA adversely affected positive strand RNA synthesis and viral mature particle formation...
  58. doi A recombinant vesicular stomatitis virus replicon vaccine protects chickens from highly pathogenic avian influenza virus (H7N1)
    Nazeer H Kalhoro
    Institut fur Virologie, Zentrum für Infektionsmedizin, Stiftung Tierarztliche Hochschule Hannover, Bunteweg 17, D 30559 Hannover, Germany
    Vaccine 27:1174-83. 2009
    ..We propose that VSV replicons have the potential to be developed to high-quality vaccines for protection of poultry against different subtypes of avian influenza viruses...
  59. pmc G, N, and P gene-based analysis of Chandipura viruses, India
    Vidya Avinash Arankalle
    National Institute of Virology, 20 A Dr Ambedkar Road, Pune 411001, Maharashtra, India
    Emerg Infect Dis 11:123-6. 2005
    ..Sequence analyses of G, N, and P genes showed 95.6%-97.6% nucleotide identity with the 1965 isolate (G gene, 7-11 amino acid changes); N and P genes were highly conserved...
  60. doi Inhibition of the IFN-beta response in hepatocellular carcinoma by alternative spliced isoform of IFN regulatory factor-3
    Sabrina Marozin
    II Medizinische Klinik und Poliklinik, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany
    Mol Ther 16:1789-97. 2008
    ..This work may provide a potential molecular basis for selecting HCC patients for oncolytic VSV therapy in future clinical trials...
  61. ncbi An outbreak of Chandipura virus encephalitis in the eastern districts of Gujarat state, India
    Mandeep S Chadha
    National Institute of Virology 20 A, Dr Ambedkar Road, Pune, Maharashtra, India
    Am J Trop Med Hyg 73:566-70. 2005
    ..The etiologic agent was Chandipura virus, which has become an important encephalitis-causing virus in India...
  62. ncbi Cytokine levels in Chandipura virus associated encephalopathy in children
    Anuradha Tripathy
    National Institute of Virology, Pune, India
    Scand J Infect Dis 37:590-3. 2005
    ..1+/-472.5 vs 113.4.+/-148.3, p = 0.01, 486.2+/-145.7 vs 113.8+/-82.4, p = 0.003). Cytokine levels were not significantly different in Groups A and B...
  63. pmc Ribose 2'-O methylation of the vesicular stomatitis virus mRNA cap precedes and facilitates subsequent guanine-N-7 methylation by the large polymerase protein
    Amal A Rahmeh
    Department of Microbiology and Molecular Genetics, Harvard Medical School, 200 Longwood Ave, Boston, MA 02115, USA
    J Virol 83:11043-50. 2009
    ..We propose a model of regulation of the activity of the C terminus of L protein in 2'-O and G-N-7 methylation of the cap structure...
  64. ncbi Chandipura virus: a major cause of acute encephalitis in children in North Telangana, Andhra Pradesh, India
    Babasaheb V Tandale
    National Institute of Virology, Pune, India
    J Med Virol 80:118-24. 2008
    ..05) than in contacts (75/77, 97.4%) and non-contacts (302/321, 94.1%) more than 15 years respectively. CHPV appears to be the major cause of acute viral encephalitis in children in endemic areas during early monsoon months...
  65. pmc Vesicular stomatitis virus inhibits mitotic progression and triggers cell death
    Papia Chakraborty
    Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    EMBO Rep 10:1154-60. 2009
    ..VSV is an oncolytic (anti-tumour) agent as it preferentially replicates and kills tumour cells. As tumour cells have a high mitotic index, VSV-mediated mitotic cell death probably contributes to its oncolytic activity...
  66. pmc Akt plays a critical role in replication of nonsegmented negative-stranded RNA viruses
    Minghao Sun
    Center of Molecular Immunology and Infectious Disease, Department of Veterinary and Biomedical Sciences, Pennsylvania State University, 115 Henning Bldg, University Park, PA 16802, USA
    J Virol 82:105-14. 2008
    ..The finding that Akt plays a critical role in replication of NNSV will lead to a better understanding of how these viruses replicate, as well as novel strategies to treat infectious diseases caused by NNSVs...
  67. doi Recombinant glycoprotein based vaccine for Chandipura virus infection
    C H Venkateswarlu
    Hepatitis Division, National Institute of Virology, Microbiological Containment Complex, Sus Road, Pashan, Pune 411021, India
    Vaccine 27:2845-50. 2009
    ..There was 60% T cell proliferation observed against rGp in immunized mice. The study shows that rGp induces both arms of immune response and represents an ideal vaccine candidate for further evaluations...
  68. pmc Cryo-EM model of the bullet-shaped vesicular stomatitis virus
    Peng Ge
    Department of Microbiology, Immunology, and Molecular Genetics, University of California at Los Angeles UCLA, Los Angeles, CA 90095 7364, USA
    Science 327:689-93. 2010
    ..Together, our data suggest a mechanism of VSV assembly in which the nucleocapsid spirals from the tip to become the helical trunk, both subsequently framed and rigidified by the M layer...
  69. pmc Opposing effects of inhibiting cap addition and cap methylation on polyadenylation during vesicular stomatitis virus mRNA synthesis
    Jianrong Li
    Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Virol 83:1930-40. 2009
    ..This work reveals that inhibiting cap addition and cap methylation have opposing effects on polyadenylation during VSV mRNA synthesis and provides evidence in support of a link between correct 5' cap formation and 3' polyadenylation...
  70. doi The E3 ubiquitin ligase Nrdp1 'preferentially' promotes TLR-mediated production of type I interferon
    Chen Wang
    National Key Laboratory of Medical Immunology and Institute of Immunology, Second Military Medical University, Shanghai, China
    Nat Immunol 10:744-52. 2009
    ..Our data suggest that Nrdp1 functions as both an adaptor protein and an E3 unbiquitin ligase to regulate TLR responses in different ways...
  71. doi Development and characterization of monoclonal antibodies to spring viraemia of carp virus
    Zhong Yuan Chen
    State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Wuhan 430072, China
    Vet Immunol Immunopathol 123:266-76. 2008
    ..At 28h after inoculation with the virus (0.01PFU/cell), 10.12% of infected cells could be distinguished from the uninfected cells. These mAbs will be useful in diagnostic test development and pathogenesis studies for fish rhabdovirus...
  72. pmc Formation of guanosine(5')tetraphospho(5')adenosine cap structure by an unconventional mRNA capping enzyme of vesicular stomatitis virus
    Tomoaki Ogino
    Department of Molecular Genetics, Section of Virology, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    J Virol 82:7729-34. 2008
    ..Interestingly, GppppA-capped and polyadenylated full-length mRNAs were also found to be synthesized by an in vitro transcription system with the native VSV RNP...
  73. pmc Sequences of vesicular stomatitis virus RNA in the region coding for leader RNA, N protein mRNA, and their junction
    D J Rowlands
    Proc Natl Acad Sci U S A 76:4793-7. 1979
    ..Other features of the RNA sequences of the two viruses are compared to each other and to published data...
  74. doi TRADD protein is an essential component of the RIG-like helicase antiviral pathway
    Marie Cecile Michallet
    Department of Biochemistry, University of Lausanne, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Immunity 28:651-61. 2008
    ..Thus, TRADD is not only an essential component of proinflammatory TNFRI signaling, but is also required for RLH-Cardif-dependent antiviral immune responses...
  75. ncbi TLR Ligand-Induced Type I IFNs Affect Thymopoiesis
    Marie Laurence Baron
    Laboratoire d Immunologie, Immunologie Humaine, Centre de recherche du Centre Hospitalier de l Universite de Montreal, Hopital Saint Luc, Montreal, Quebec, Canada
    J Immunol 180:7134-46. 2008
    ..Because TLR ligands are widely used as vaccine adjuvants, their immunomodulatory actions mediated mainly by IFN-alpha suggested by our results should be taken in consideration...
  76. doi Detection of spring viraemia of carp virus (SVCV) by loop-mediated isothermal amplification (LAMP) in koi carp, Cyprinus carpio L
    R B Shivappa
    College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA
    J Fish Dis 31:249-58. 2008
    ..The isothermal temperature requirements, high specificity and sensitivity, and short incubation time of the RT-LAMP assay make it an excellent choice as a field diagnostic test for SVCV...
  77. ncbi Incidence of neutralizing antibodies to Chandipura virus in domestic animals from Karimnagar and Warangal Districts of Andhra Pradesh, India
    M V Joshi
    National Institute of Virology, Pune 411 001, Maharashtra, India
    Acta Virol 49:69-71. 2005
    ....
  78. ncbi Characterization of complete genome sequence of the spring viremia of carp virus isolated from common carp (Cyprinus carpio) in China
    Y Teng
    State Key Laboratory of Biocontrol, College of Life Sciences, Sun Yat Sen University, Guangzhou, P R China
    Arch Virol 152:1457-65. 2007
    ..This is the first report of a complete genome sequence of SVCV isolated from cultured carp in China. Phylogenetic analysis indicates that SVCV A-1 is closely related to the members of the genus Vesiculovirus, family Rhabdoviridae.
  79. ncbi Venereal transmission of Chandipura virus by Phlebotomus papatasi (Scopoli)
    M S Mavale
    Entomology Department, National Institute of Virology, Pashan, Pune, India
    Am J Trop Med Hyg 75:1151-2. 2006
    ..The infection rate was found to be 12.5% in uninfected females when mated with infected males. The occurrence of venereal transmission of this virus may have epidemiologic importance in the natural cycle of CHPV...
  80. ncbi Experimental transmission of Chandipura virus by Phlebotomus argentipes (diptera: psychodidae)
    Mangala S Mavale
    National Institute of Virology, Pune, India
    Am J Trop Med Hyg 76:307-9. 2007
    ..The susceptibility of P. argentipes to CHPV and its potential to transmit the virus by bite has importance in epidemiology of CHPV...
  81. ncbi Emerging vesiculo-type virus infections of freshwater fishes in Europe
    A M Betts
    Centre for the Environment, Fisheries and Aquaculture Science, Barrack Road, Weymouth, Dorset DT4 8UB, UK
    Dis Aquat Organ 57:201-12. 2003
    ..particles appeared to be compact, with spikes visible at the surface, a morphology similar to that of the vesiculovirus group of rhabdoviruses...
  82. ncbi Assessment of commercial test kits for identification of spring viraemia of carp virus
    P F Dixon
    CEFAS Weymouth Laboratory, Barrack Road, The Nothe, Weymouth, Dorset DT4 8UB, UK
    Dis Aquat Organ 67:25-9. 2005
    ..However, the IFAT was too specific and detected SVCV isolates from only 1 of the 4 SVCV subgroups. Reliance on these test kits alone could result in misidentification of this OIE notifiable disease...
  83. ncbi Contact transmission of vesicular stomatitis virus New Jersey in pigs
    D E Stallknecht
    Southeastern Cooperative Wildlife Disease Study, College of Veterinary Medicine, University of Georgia, Athens 30602, USA
    Am J Vet Res 62:516-20. 2001
    ..Long-term maintenance of VSV-NJ via contact transmission alone appears unlikely. Pigs represent an efficient large-animal system for further study of VSV-NJ pathogenesis and transmission...
  84. ncbi Isolation of a vesicular virus belonging to the family rhabdoviridae from the aqueous humor of a patient with bilateral corneal endotheliitis
    Hajib N Madhavan
    Vision Research Foundation, Sankara Nethralaya, Chennai, India
    Cornea 21:333-5. 2002
    ..To report bilateral corneal endotheliitis caused by a vesicular virus (family Rhabdoviridae)...
  85. ncbi [Deadly encephalitis epidemic in India caused by the Chandipura virus]
    Dieter Hassler
    Dtsch Med Wochenschr 128:1817. 2003
  86. ncbi Diagnosis of Brazilian vesiculoviruses by reverse transcription-polymerase chain reaction
    Daniela Wey Bonutti
    Centro de Pesquisa em Virologia, Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo, Av Bandeirantes 3900, 14049 000 Ribeirão Preto, SP, Brasil
    Mem Inst Oswaldo Cruz 100:193-6. 2005
    ..The RNA extracts of viral and clinical samples were submitted to a RT-PCR using Vesiculovirus G primers that amplify part of the glycoprotein gene...
  87. ncbi Detection of chandipura virus from sand flies in the genus Sergentomyia (Diptera: Phlebotomidae) at Karimnagar District, Andhra Pradesh, India
    G Geevarghese
    National Institute of Virology, 20 A, Dr Ambedkar Road, Pune 411001, India
    J Med Entomol 42:495-6. 2005
    ..Fifteen pools, each containing two specimens, were tested by reverse transcriptase-polymerase chain reaction and sequencing. One pool of Sergentomyia from Kolanur village in Karimnagar District was positive for CHPV...
  88. ncbi Genotyping spring viraemia of carp virus and other piscine vesiculo-like viruses using reverse hybridisation
    A M Sheppard
    Centre for Environment, Fisheries and Aquaculture Science, Weymouth Laboratory, Barrack Road, Weymouth, Dorset DT4 8UB, UK
    Dis Aquat Organ 76:163-8. 2007
    ..The assay offers a practical solution for diagnostic laboratories that currently lack a sequencing capability to confirm the nature of PCR products generated in suspected SVCV cases...
  89. ncbi First detection and confirmation of spring viraemia of carp virus in common carp, Cyprinus carpio L., from Hamilton Harbour, Lake Ontario, Canada
    K A Garver
    Department of Fisheries and Oceans, Pacific Biological Station, Nanaimo, BC, Canada
    J Fish Dis 30:665-71. 2007
    ..9% nucleotide identity). This is the first report of the detection of SVCV in Canada...
  90. pmc Generation of antiviral major histocompatibility complex class I-restricted T cells in the absence of CD8 coreceptors
    Nicolas P Andrews
    Department of Pathology, Emory University School of Medicine, Woodruff Memorial Research Building, 101 Woodruff Circle, Atlanta, GA 30322, USA
    J Virol 82:4697-705. 2008
    ..These findings provide a possible explanation for the resistance of CD8-deficient mice to PyV-induced tumors and have implications for the maintenance of virus-specific MHC-I-restricted T cells during persistent infection...
  91. doi Simultaneous detection of three fish rhabdoviruses using multiplex real-time quantitative RT-PCR assay
    Zongxiao Liu
    College of Fisheries, Huazhong Agricultural University, Wuhan 430070, PR China Show how Bio tech Institute, Beihai 536000, PR China
    J Virol Methods 149:103-9. 2008
    ..This assay has the potential to be used for both research applications and diagnosis...
  92. ncbi Efficient production of canine interferon-alpha in silkworm Bombyx mori by use of a BmNPV/Bac-to-Bac expression system
    Zhao Na
    College of Animal Sciences, Zhejiang University, Huajiachi Campus, Hangzhou, 310029, China
    Appl Microbiol Biotechnol 78:221-6. 2008
    ..The method established in this study provides an efficient way to produce a large amount of CaIFN-alpha and paves the way for further utilization of this protein as a therapeutic agent or vaccine adjuvant in dogs...
  93. pmc Cloning and expression of the vesicular stomatitis virus phosphoprotein gene in Escherichia coli: analysis of phosphorylation status versus transcriptional activity
    S Barik
    Department of Molecular Biology, Cleveland Clinic Foundation, Ohio 44195
    J Virol 65:1719-26. 1991
    ..However, the P protein was phosphorylated in vitro by the kinase activities associated with L and the N-RNA template...
  94. ncbi In vitro effects of recombinant zebrafish IFN on spring viremia of carp virus and infectious hematopoietic necrosis virus
    Li Wang
    Department of Microbiology and Immunology, College of Veterinary Medicine, China Agricultural University, Beijing 100094, China
    J Interferon Cytokine Res 26:256-9. 2006
    ..The results indicate that rDreIFN has higher activity against SVCV and IHNV on epithelioma papulosum cyprinid (EPC) than on grass carp (C. idellus) ovary (CO) cell lines and no activity against VSV on chick embryo fibroblasts (CEF)...
  95. ncbi Combined VSV oncolytic virus and chemotherapy for squamous cell carcinoma
    Chih Kwang Sung
    Department of Otolaryngology Head and Neck Surgery, Mount Sinai School of Medicine, New York, New York 10029, USA
    Laryngoscope 118:237-42. 2008
    ..Here we evaluate the potential to combine a potent chemotherapeutic agent for SCC (cisplatin) with rVSV-F and rVSV-IL12 to improve efficacy...
  96. pmc Polymerase errors accumulating during natural evolution of the glycoprotein gene of vesicular stomatitis virus Indiana serotype isolates
    P A Bilsel
    Cell and Molecular Biology Program, School of Veterinary Medicine, University of Nevada, Reno 89557
    J Virol 64:4873-83. 1990
    ..Analysis of the deduced amino acid sequence differences among VSV IND type 1 viruses revealed numerous substitutions within defined antigenic epitopes, suggesting that immune selection may play a role in the evolution of these viruses...
  97. ncbi Vertical and venereal transmission of Chandipura virus (Rhabdoviridae) by Aedes aegypti (Diptera: Culicidae)
    M S Mavale
    National Institute of Virology, 20 A, Drive Ambedkar Road, Pune 411001, India
    J Med Entomol 42:909-11. 2005
    ..9 and 1.4%, respectively. The venereal infection rate of CHPV among inseminated females was 32.7%. Our study indicates the possible occurrence of vertical and venereal transmission of CHPV in insect vectors...
  98. ncbi The evolving epidemiology of viral encephalitis
    James J Sejvar
    Division of Viral and Rickettsial Diseases and Division of Vector Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Curr Opin Neurol 19:350-7. 2006
    ....
  99. pmc 20-HETE-mediated cytotoxicity and apoptosis in ischemic kidney epithelial cells
    Vani Nilakantan
    Department of Transplant Surgery, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Am J Physiol Renal Physiol 294:F562-70. 2008
    ....
  100. doi Disruption of Pichia pastoris PMR1 gene decreases its folding capacity on human serum albumin and interferon-alpha2b fusion protein
    Hong Liang Zhao
    Department of Microorganism Engineering, Beijing Institute of Biotechnology, 20 Dongdajie Street, Fengtai District, Beijing 100071, People s Republic of China
    Yeast 25:279-86. 2008
    ..To be secreted homogeneously from Pppmr1 and to be stable in aqueous solution, the linker of the fusion protein should be extended to 10 amino acid residues...
  101. doi Identification of MAVS splicing variants that interfere with RIGI/MAVS pathway signaling
    Sonya P Lad
    Department of Immunology, The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, CA 92037, USA
    Mol Immunol 45:2277-87. 2008
    ..MAVS 1b interacts with RIP1 and FADD and exhibits anti-viral activity against VSV infection. This study uncovers MAVS splicing variants of diverse biological function...

Research Grants109 found, 100 shown here

  1. QUALITATIVE NATURE OF ANTIBODIES TO HCV GLYCOPROTEIN SUBUNIT VACCINE IN HUMANS
    Ranjit Ray; Fiscal Year: 2007
    ..Our proposed complimentary experimental approaches in this vaccinated cohort will help in developing successful vaccine strategies for the intervention of the first crucial step of the HCV life cycle. ..
  2. IMMUNE RESPONSES TO VSV/HIV/SIV HYBRIDS IN MACAQUES
    John Rose; Fiscal Year: 2002
    ..the viruses to be constructed will have envelopes from either of the two VSV serotypes or from a second vesiculovirus. The use of the different envelopes will allow boosting without neutralization of the vector itself. Dr...
  3. GABA-EXCITATORY TRANSMITTER IN DEVELOPING HYPOTHALAMUS
    Anthony van den Pol; Fiscal Year: 2002
    ..Thus, what we learn from our experiments on hypothalamic neurons should have general applicability to other CNS neurons. ..
  4. DETERMINANTS OF AXON LENGTH FOLLOWING INJURY
    Anthony van den Pol; Fiscal Year: 2002
    ..We will use their transgenic mouse to study the attributes of olfactory ensheathing cells in enhancing axonal recovery after cord injury. ..
  5. NPY DEPRESSION OF HIPPOCAMPAL EPILEPSY
    Anthony van den Pol; Fiscal Year: 2002
    ..NPY is potentially of great interest because its primary action in the normal hippocampus appears to be one of depressing hyperexcited neurons, without a substantial effect on normal neurotransmission. ..
  6. GABA: EXCITATORY TRANSMITTER IN DEVELOPING HYPOTHALAMUS
    Anthony van den Pol; Fiscal Year: 2007
    ..GABA's excitatory actions during development are widespread throughout the brain. Thus, what we learn from our experiments on hypothalamic neurons should have general applicability to other CNS neurons. ..
  7. Hypocretin Neurons
    Anthony van den Pol; Fiscal Year: 2006
    ..Together, these experiments will provide a better understanding of the cellular mechanisms underlying hypocretin actions and neuronal communication to and from hypocretin neurons. ..
  8. Hypocretin Neurons
    Anthony van den Pol; Fiscal Year: 2007
    ..Understanding the role of the endogenous opioid in hypocretin cells should also facilitate the understanding and treatment of narcolepsy. ..
  9. Cytomegalovirus in the Brain
    Anthony van den Pol; Fiscal Year: 2005
    ..Virus mediated changes in intracellular ion levels, ion currents, transmitter responses, and membrane properties will be compared in CMV infected and control cells. ..
  10. Oncolytic Virus Targets Brain Tumors
    Anthony van den Pol; Fiscal Year: 2007
    ..The primary goal of these studies is to test the efficacy and safety of variant oncolytic VSVs as the first step as a potential treatment for currently incurable human brain tumors. ..
  11. Cytomegalovirus in the Brain
    Anthony van den Pol; Fiscal Year: 2007
    ..These experiments will help us understand the mechanisms associated with CMV-induced neurological dysfunction, and how to combat the virus within the brain with minimal complications. ..
  12. Response properties of hypothalamic MCH neurons
    Anthony van den Pol; Fiscal Year: 2009
    ..Studies of the cellular physiology of MCH neurons should provide a better understanding of the role of this system in regulating energy homeostasis and obesity. ..
  13. Oncolytic Virus Targets Brain Tumors
    Anthony N van den Pol; Fiscal Year: 2010
    ..The primary goal of these studies is to test the efficacy and safety of variant oncolytic VSVs as the first step as a potential treatment for currently incurable human brain tumors. ..
  14. Cytomegalovirus in the Brain
    Anthony N van den Pol; Fiscal Year: 2010
    ..These experiments will help us understand the mechanisms associated with CMV-induced neurological dysfunction, and how to combat the virus within the brain with minimal complications. ..
  15. Response properties of hypothalamic MCH neurons
    Anthony N van den Pol; Fiscal Year: 2010
    ....
  16. Hypocretin Neurons
    Anthony N van den Pol; Fiscal Year: 2010
    ..Understanding the role of the endogenous opioid in hypocretin cells should also facilitate the understanding and treatment of narcolepsy. ..
  17. Cytomegalovirus in the Brain
    Anthony van den Pol; Fiscal Year: 2009
    ..These experiments will help us understand the mechanisms associated with CMV-induced neurological dysfunction, and how to combat the virus within the brain with minimal complications. ..
  18. Arcuate nucleus glutamatergic neurons modulate energy homeostasis
    Anthony N van den Pol; Fiscal Year: 2010
    ..Similar to other neurons of the arcuate nucleus that serve multiple homeostatic functions, the function of the excitatory arcuate glutamate neuron may include other roles in addition to that of energy homeostasis. ..
  19. The role of autophagy in innate anti-viral immunity in Drosophila
    Sara Cherry; Fiscal Year: 2010
    ..The identification of new host factors amenable to inhibition may lead to targets for much-needed antiviral therapeutics. ..
  20. The role of autophagy in innate anti-viral immunity in Drosophila
    Sara Cherry; Fiscal Year: 2007
    ..The identification of new host factors amenable to inhibition may lead to targets for much-needed antiviral therapeutics. ..
  21. Mechanisms of Liver Disease Progression by Hepatitis C Virus
    Ranjit Ray; Fiscal Year: 2010
    ..We plan to understand the molecular determinants involved in HCV mediated liver disease progression, which will open avenues for novel therapeutic approach. ..
  22. Fusion Inhibitors of Influenza Virus
    Ming Luo; Fiscal Year: 2010
    ..Experiments are designed to study the mechanism of inhibition by these compounds. The outcome will help the design of novel fusion inhibitors that may become potential antiviral drugs of influenza viruses. ..
  23. VSV-based Therapeutic Papilloma Vaccine
    Janet Brandsma; Fiscal Year: 2007
    ..The data provided by this investigation are likely to aid in the development a highly effective HPV vaccine to protect women against cervical cancer. ..
  24. Assembly of the negative stranded RNA virus core
    Ming Luo; Fiscal Year: 2010
    ..M was copurified with the P-N-RNA complex. Crystallization and cryoEM studies of this complex are in progress. The result will show how M may interact with the N-RNA complex, and perhaps with P as well. ..
  25. QUALITATIVE NATURE OF ANTIBODIES TO HCV GLYCOPROTEIN SUBUNIT VACCINE IN HUMANS
    Ranjit Ray; Fiscal Year: 2009
    ..Our proposed complimentary experimental approaches in this vaccinated cohort will help in developing successful vaccine strategies for the intervention of the first crucial step of the HCV life cycle. ..
  26. HCV ENVELOPE GLYCOPROTEINS AND VACCINE DEVELOPMENT
    Ranjit Ray; Fiscal Year: 2003
    ....
  27. Papillomavirus E2 as a cervical/anal cancer drug target
    Janet Brandsma; Fiscal Year: 2005
    ..Vectors containing a conditional wild-type CRPV E2 transgene will be used to determine the effects of E2 overexpression. ..
  28. Functional Activities of HCV Core Protein
    Ranjit Ray; Fiscal Year: 2005
    ....
  29. RNA Interference for the Treatment of Ebola and Marburg Hemorrhagic Fever
    Ian MacLachlan; Fiscal Year: 2010
    ....
  30. Assembly of the negative stranded RNA virus core
    Ming Luo; Fiscal Year: 2009
    ..M was copurified with the P-N- RNA complex. Crystallization and cryoEM studies of this complex are in progress. The result will show how M may interact with the N-RNA complex, and perhaps with P as well. ..
  31. Assembly of the negative stranded RNA virus core
    Ming Luo; Fiscal Year: 2007
    ..M was copurified with the P-N-RNA complex. Crystallization and cryoEM studies of this complex are in progress. The result will show how M may interact with the N-RNA complex, and perhaps with P as well. ..
  32. ANALYSIS OF RESPIRATORY SYNCYTIAL VIRUS GENE PRODUCTS
    GAIL WERTZ; Fiscal Year: 1992
    ..8. Examine the function of the RS nonstructural proteins 1B and 1C, and the 1A and 22K proteins. 9. Examine the role of the nonstructural proteins and the 1A and 22K proteins in infection and in cell mediated immune responses...