dengue virus

Summary

Summary: A species of the genus FLAVIVIRUS which causes an acute febrile and sometimes hemorrhagic disease in man. Dengue is mosquito-borne and four serotypes are known.

Top Publications

  1. ncbi Dengue: a continuing global threat
    Maria G Guzman
    Instituto de Medicina Tropical, Pedro Kouri, PO Box 601, Marianao 13, Ciucad de la Habana, Cuba
    Nat Rev Microbiol 8:S7-16. 2010
  2. ncbi Successful establishment of Wolbachia in Aedes populations to suppress dengue transmission
    A A Hoffmann
    Bio21 Institute, Department of Genetics, The University of Melbourne, Victoria 3010, Australia
    Nature 476:454-7. 2011
  3. pmc Dengue and dengue hemorrhagic fever
    D J Gubler
    Division of Vector Borne Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado 80522, USA
    Clin Microbiol Rev 11:480-96. 1998
  4. ncbi A Wolbachia symbiont in Aedes aegypti limits infection with dengue, Chikungunya, and Plasmodium
    Luciano A Moreira
    School of Biological Sciences, The University of Queensland, Brisbane QLD 4072, Australia
    Cell 139:1268-78. 2009
  5. pmc The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus
    Abraham L Brass
    Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard Medical School, Charlestown, MA 02129, USA
    Cell 139:1243-54. 2009
  6. pmc Wolbachia induces reactive oxygen species (ROS)-dependent activation of the Toll pathway to control dengue virus in the mosquito Aedes aegypti
    Xiaoling Pan
    Department of Entomology and Genetics Program, Michigan State University, East Lansing, MI 48824, USA
    Proc Natl Acad Sci U S A 109:E23-31. 2012
  7. ncbi Dengue viremia titer, antibody response pattern, and virus serotype correlate with disease severity
    D W Vaughn
    Department of Virus Diseases, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA
    J Infect Dis 181:2-9. 2000
  8. ncbi Immune response to dengue virus and prospects for a vaccine
    Brian R Murphy
    Laboratory of Infectious Diseases, National Institutes of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA
    Annu Rev Immunol 29:587-619. 2011
  9. ncbi Dengue
    Scott B Halstead
    Supportive Research and Development, Pediatric Dengue Vaccine Initiative, Internal Vaccine Institute, Seoul, South Korea
    Lancet 370:1644-52. 2007
  10. ncbi Global spread and persistence of dengue
    Jennifer L Kyle
    Division of Infectious Diseases, School of Public Health, and Graduate Group in Microbiology, University of California, Berkeley, California 94720 7354, USA
    Annu Rev Microbiol 62:71-92. 2008

Detail Information

Publications314 found, 100 shown here

  1. ncbi Dengue: a continuing global threat
    Maria G Guzman
    Instituto de Medicina Tropical, Pedro Kouri, PO Box 601, Marianao 13, Ciucad de la Habana, Cuba
    Nat Rev Microbiol 8:S7-16. 2010
    ..Illness is produced by any of the four dengue virus serotypes...
  2. ncbi Successful establishment of Wolbachia in Aedes populations to suppress dengue transmission
    A A Hoffmann
    Bio21 Institute, Department of Genetics, The University of Melbourne, Victoria 3010, Australia
    Nature 476:454-7. 2011
    ..These findings demonstrate that Wolbachia-based strategies can be deployed as a practical approach to dengue suppression with potential for area-wide implementation...
  3. pmc Dengue and dengue hemorrhagic fever
    D J Gubler
    Division of Vector Borne Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado 80522, USA
    Clin Microbiol Rev 11:480-96. 1998
    ..A major challenge for public health officials in all tropical areas of the world is to develop and implement sustainable prevention and control programs that will reverse the trend of emergent dengue hemorrhagic fever...
  4. ncbi A Wolbachia symbiont in Aedes aegypti limits infection with dengue, Chikungunya, and Plasmodium
    Luciano A Moreira
    School of Biological Sciences, The University of Queensland, Brisbane QLD 4072, Australia
    Cell 139:1268-78. 2009
    ..We suggest that this Wolbachia-mediated pathogen interference may work synergistically with the life-shortening strategy proposed previously to provide a powerful approach for the control of insect transmitted diseases...
  5. pmc The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus
    Abraham L Brass
    Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard Medical School, Charlestown, MA 02129, USA
    Cell 139:1243-54. 2009
    ..characterization revealed that the IFITM proteins inhibit the early replication of flaviviruses, including dengue virus and West Nile virus...
  6. pmc Wolbachia induces reactive oxygen species (ROS)-dependent activation of the Toll pathway to control dengue virus in the mosquito Aedes aegypti
    Xiaoling Pan
    Department of Entomology and Genetics Program, Michigan State University, East Lansing, MI 48824, USA
    Proc Natl Acad Sci U S A 109:E23-31. 2012
    ..introduced to nonnative mosquito hosts, Wolbachia induce resistance to a number of human pathogens, including dengue virus (DENV), Plasmodium, and filarial nematodes, but the molecular mechanism involved is unclear...
  7. ncbi Dengue viremia titer, antibody response pattern, and virus serotype correlate with disease severity
    D W Vaughn
    Department of Virus Diseases, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA
    J Infect Dis 181:2-9. 2000
    Viremia titers in serial plasma samples from 168 children with acute dengue virus infection who were enrolled in a prospective study at 2 hospitals in Thailand were examined to determine the role of virus load in the pathogenesis of ..
  8. ncbi Immune response to dengue virus and prospects for a vaccine
    Brian R Murphy
    Laboratory of Infectious Diseases, National Institutes of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA
    Annu Rev Immunol 29:587-619. 2011
    b>Dengue virus (DENV) is a mosquito-borne member of the Flavivirus genus and includes four serotypes (DENV-1, DENV-2, DENV-3, and DENV-4), each of which is capable of causing dengue fever and dengue hemorrhagic fever/dengue shock syndrome...
  9. ncbi Dengue
    Scott B Halstead
    Supportive Research and Development, Pediatric Dengue Vaccine Initiative, Internal Vaccine Institute, Seoul, South Korea
    Lancet 370:1644-52. 2007
    ..Here, I review and discuss data on clinical diagnosis and pathophysiology of vascular permeability and coagulopathy, parenteral treatment of DHF/DSS, and new laboratory tests...
  10. ncbi Global spread and persistence of dengue
    Jennifer L Kyle
    Division of Infectious Diseases, School of Public Health, and Graduate Group in Microbiology, University of California, Berkeley, California 94720 7354, USA
    Annu Rev Microbiol 62:71-92. 2008
    ..urbanization in tropical and subtropical countries, breeding sites for the mosquitoes that transmit dengue virus have proliferated, and successful vector control has proven problematic...
  11. ncbi Stable introduction of a life-shortening Wolbachia infection into the mosquito Aedes aegypti
    Conor J McMeniman
    School of Integrative Biology, University of Queensland, Brisbane 4072, Australia
    Science 323:141-4. 2009
    ..Our data suggest that targeting mosquito age with inherited Wolbachia infections may be a viable strategy to reduce the transmission of pathogens such as dengue viruses...
  12. pmc Impact of daily temperature fluctuations on dengue virus transmission by Aedes aegypti
    Louis Lambrechts
    Department of Virology, Institut Pasteur, 75724 Paris Cedex 15, France
    Proc Natl Acad Sci U S A 108:7460-5. 2011
    ..Here, we show that diurnal temperature range (DTR) affects two important parameters underlying dengue virus (DENV) transmission by Aedes aegypti...
  13. pmc Consequences of the expanding global distribution of Aedes albopictus for dengue virus transmission
    Louis Lambrechts
    Department of Virology, Institut Pasteur, Paris, France
    PLoS Negl Trop Dis 4:e646. 2010
    ..of numerous arthropod-borne viruses (arboviruses), including the most prevalent arboviral pathogen of humans, dengue virus (DENV). Ae...
  14. ncbi Critical review of the vector status of Aedes albopictus
    N G Gratz
    Med Vet Entomol 18:215-27. 2004
    ..albopictus in countries endemic for dengue and other arboviruses (e.g. Chikungunya, EEE, Ross River, WNV, LaCrosse and other California group viruses), for which it would be competent and ecologically suited to serve as a bridge vector...
  15. pmc Cross-reacting antibodies enhance dengue virus infection in humans
    Wanwisa Dejnirattisai
    Department of Medicine, Imperial College London, London W12 0NN, UK
    Science 328:745-8. 2010
    b>Dengue virus co-circulates as four serotypes, and sequential infections with more than one serotype are common...
  16. pmc The human immune response to Dengue virus is dominated by highly cross-reactive antibodies endowed with neutralizing and enhancing activity
    Martina Beltramello
    Institute for Research in Biomedicine, Bellinzona 6500, Switzerland
    Cell Host Microbe 8:271-83. 2010
    Antibodies protect against homologous Dengue virus (DENV) infection but can precipitate severe dengue by promoting heterotypic virus entry via Fcγ receptors (FcγR)...
  17. pmc The role of human movement in the transmission of vector-borne pathogens
    Steven T Stoddard
    Entomology, University of California, Davis, California, United States of America
    PLoS Negl Trop Dis 3:e481. 2009
    ..Here we develop a conceptual model to evaluate the importance of variation in exposure due to individual human movements for pathogen transmission, focusing on mosquito-borne dengue virus.
  18. pmc The Aedes aegypti toll pathway controls dengue virus infection
    Zhiyong Xi
    W Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States of America
    PLoS Pathog 4:e1000098. 2008
    ..gene expression and RNA interference (RNAi)-based reverse genetic analyses, to characterize its response to dengue virus infection in different body compartments...
  19. ncbi From research to phase III: preclinical, industrial and clinical development of the Sanofi Pasteur tetravalent dengue vaccine
    Bruno Guy
    Research and Development, Sanofi Pasteur, 69280 Marcy l Etoile, France
    Vaccine 29:7229-41. 2011
    ..fever vaccine 17D (YFV 17D) backbone, each expressing the pre-membrane and envelope genes of one of the four dengue virus serotypes...
  20. ncbi Localization of dengue virus in naturally infected human tissues, by immunohistochemistry and in situ hybridization
    Kala Jessie
    Department of Pathology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    J Infect Dis 189:1411-8. 2004
    ..Positive-strand viral RNA was detected in the same IHC-positive cells found in the spleen and blood-clot samples. The strong, positive ISH signal in these cells indicated a high copy number of viral RNA, suggesting replication...
  21. pmc RNA interference screen for human genes associated with West Nile virus infection
    Manoj N Krishnan
    Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticutt 06520 8031, USA
    Nature 455:242-5. 2008
    ..By extending this study to dengue virus, we show that flaviviruses have both overlapping and unique interaction strategies with host cells...
  22. ncbi Next generation dengue vaccines: a review of candidates in preclinical development
    Julia Schmitz
    Initiative for Vaccine Research, World Health Organization, Geneva, Switzerland
    Vaccine 29:7276-84. 2011
    ..This review provides an overview of the various technological approaches to dengue vaccine development and specifically focuses on candidates in preclinical development...
  23. ncbi Structure of the dengue virus envelope protein after membrane fusion
    Yorgo Modis
    Howard Hughes Medical Institute, Children s Hospital and Harvard Medical School, 320 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nature 427:313-9. 2004
    b>Dengue virus enters a host cell when the viral envelope glycoprotein, E, binds to a receptor and responds by conformational rearrangement to the reduced pH of an endosome...
  24. pmc Structure of dengue virus: implications for flavivirus organization, maturation, and fusion
    Richard J Kuhn
    Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA
    Cell 108:717-25. 2002
    ..The structure suggests that flaviviruses, and by analogy also alphaviruses, employ a fusion mechanism in which the distal beta barrels of domain II of the glycoprotein E are inserted into the cellular membrane...
  25. ncbi Protective efficacy of the recombinant, live-attenuated, CYD tetravalent dengue vaccine in Thai schoolchildren: a randomised, controlled phase 2b trial
    Arunee Sabchareon
    Department of Tropical Pediatrics, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Lancet 380:1559-67. 2012
    ..Roughly half the world's population live in dengue-endemic countries, but no vaccine is licensed. We investigated the efficacy of a recombinant, live, attenuated tetravalent dengue vaccine...
  26. pmc The endosymbiotic bacterium Wolbachia induces resistance to dengue virus in Aedes aegypti
    Guowu Bian
    Department of Entomology and Genetics Program, Michigan State University, East Lansing, Michigan, United States of America
    PLoS Pathog 6:e1000833. 2010
    ..Given the large overlap in tissue distribution and intracellular localization between Wolbachia and dengue virus in mosquitoes, we conducted experiments to characterize their interactions...
  27. pmc Dengue virus type 2 infections of Aedes aegypti are modulated by the mosquito's RNA interference pathway
    Irma Sanchez-Vargas
    Department of Microbiology, Arthropod Borne and Infectious Diseases Laboratory, Colorado State University, Fort Collins, Colorado, United States of America
    PLoS Pathog 5:e1000299. 2009
    ..have shown that both innate and adaptive immune defense mechanisms greatly influence the course of human dengue virus (DENV) infections, but little is known about the innate immune response of the mosquito vector Aedes aegypti to ..
  28. pmc Identification of five interferon-induced cellular proteins that inhibit west nile virus and dengue virus infections
    Dong Jiang
    Drexel Institute for Biotechnology and Virology Research, Department of Microbiology and Immunology, Drexel University College of Medicine, Doylestown, Pennsylvania 18902, USA
    J Virol 84:8332-41. 2010
    ..that instigate an antiviral state against two medically important flaviviruses, West Nile virus (WNV) and dengue virus (DENV), we tested 36 ISGs that are commonly induced by IFN-alpha for antiviral activity against the two viruses...
  29. ncbi Original antigenic sin and apoptosis in the pathogenesis of dengue hemorrhagic fever
    Juthathip Mongkolsapaya
    MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, OX3 9DS, UK
    Nat Med 9:921-7. 2003
    b>Dengue virus presents a growing threat to public health in the developing world...
  30. ncbi Immunity to dengue virus: a tale of original antigenic sin and tropical cytokine storms
    Alan L Rothman
    Institute for Immunology and Informatics and Department of Cell and Molecular Biology, University of Rhode Island, Providence, Rhode Island 02903, USA
    Nat Rev Immunol 11:532-43. 2011
    ..The existence of four viral serotypes and the association of prior dengue virus infection with an increased risk for more severe disease have presented significant obstacles to vaccine ..
  31. pmc Wolbachia-mediated resistance to dengue virus infection and death at the cellular level
    Francesca D Frentiu
    School of Biological Sciences, The University of Queensland, Brisbane, Australia
    PLoS ONE 5:e13398. 2010
    Dengue is currently the most important arthropod-borne viral disease of humans. Recent work has shown dengue virus displays limited replication in its primary vector, the mosquito Aedes aegypti, when the insect harbors the endosymbiotic ..
  32. ncbi CLEC5A is critical for dengue-virus-induced lethal disease
    Szu Ting Chen
    Department and Institute of Microbiology and Immunology, National Yang Ming University, Taipei 112, Taiwan
    Nature 453:672-6. 2008
    Dengue haemorrhagic fever and dengue shock syndrome, the most severe responses to dengue virus (DV) infection, are characterized by plasma leakage (due to increased vascular permeability) and low platelet counts...
  33. ncbi The origin, emergence and evolutionary genetics of dengue virus
    Edward C Holmes
    Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK
    Infect Genet Evol 3:19-28. 2003
    ..Herein we show how the comparative analysis of gene sequence data has shed light on the origin and spread of dengue virus, as well as on the evolutionary processes that structure its genetic diversity...
  34. pmc Dengue virus-induced autophagy regulates lipid metabolism
    Nicholas S Heaton
    Department of Microbiology, The University of Chicago, Chicago, IL 60637, USA
    Cell Host Microbe 8:422-32. 2010
    ..However, some viruses, including dengue virus (DENV), usurp autophagy to enhance their replication...
  35. ncbi Dengue virus infectivity depends on envelope protein binding to target cell heparan sulfate
    Y Chen
    Department of Internal Medicine, University of Michigan, Ann Arbor 48109, USA
    Nat Med 3:866-71. 1997
    b>Dengue virus is a human pathogen that has reemerged as an increasingly important public health threat...
  36. ncbi Composition and three-dimensional architecture of the dengue virus replication and assembly sites
    Sonja Welsch
    Department of Molecular Virology, University of Heidelberg, Im Neuenheimer Feld 345, Heidelberg D 69120, Germany
    Cell Host Microbe 5:365-75. 2009
    ..Using electron microscopy, we find Dengue virus (DENV)-induced vesicles, convoluted membranes, and virus particles to be endoplasmic reticulum (ER)-derived, ..
  37. pmc DC-SIGN (CD209) mediates dengue virus infection of human dendritic cells
    Boonrat Tassaneetrithep
    Division of Retrovirology, Walter Reed Army Institite of Research and Henry M Jackson Foundation for the Advancement of Military Medicine Diseases, Rockville, MD 20850, USA
    J Exp Med 197:823-9. 2003
    b>Dengue virus is a single-stranded, enveloped RNA virus that productively infects human dendritic cells (DCs) primarily at the immature stage of their differentiation...
  38. ncbi Prospects for a dengue virus vaccine
    Stephen S Whitehead
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Rev Microbiol 5:518-28. 2007
    ..A tetravalent vaccine is urgently needed and must be effective against all four dengue virus serotypes, be cost-effective and provide long-term protection...
  39. pmc An evolutionary conserved function of the JAK-STAT pathway in anti-dengue defense
    Jayme A Souza-Neto
    W Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, The Johns Hopkins University, 615 North Wolfe Street E4209, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 106:17841-6. 2009
    Here, we show that the major mosquito vector for dengue virus uses the JAK-STAT pathway to control virus infection. Dengue virus infection in Aedes aegypti mosquitoes activates the JAK-STAT immune signaling pathway...
  40. pmc Dengue--quo tu et quo vadis?
    Rubing Chen
    Department of Pathology, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555, USA
    Viruses 3:1562-608. 2011
    ....
  41. pmc Dengue infection increases the locomotor activity of Aedes aegypti females
    Tamara N Lima-Camara
    Laboratório de Biologia Molecular de Insetos, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, Brazil
    PLoS ONE 6:e17690. 2011
    ..It is known that viruses and other parasites can potentially alter vector behavior. We investigated whether infection with Dengue virus modifies the behavior of Aedes aegypti females with respect to their activity level.
  42. pmc Global cross-talk of genes of the mosquito Aedes aegypti in response to dengue virus infection
    Susanta K Behura
    Eck Institute for Global Health, Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana, USA
    PLoS Negl Trop Dis 5:e1385. 2011
    The mosquito Aedes aegypti is the primary vector of dengue virus (DENV) infection in humans, and DENV is the most important arbovirus across most of the subtropics and tropics worldwide...
  43. ncbi Mechanism of dengue virus broad cross-neutralization by a monoclonal antibody
    Joseph J B Cockburn
    Unité de Virologie Structurale, Departement de Virologie, Institut Pasteur, 75724 Paris Cedex 15, France
    Structure 20:303-14. 2012
    The dengue virus (DENV) complex is composed of four distinct but serologically related flaviviruses, which together cause the present-day most important emerging viral disease...
  44. pmc Dengue virus nonstructural protein 3 redistributes fatty acid synthase to sites of viral replication and increases cellular fatty acid synthesis
    Nicholas S Heaton
    Department of Microbiology, University of Chicago, Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 107:17345-50. 2010
    b>Dengue virus (DENV) modifies cellular membranes to establish its sites of replication...
  45. pmc ISG15 facilitates cellular antiviral response to dengue and west nile virus infection in vitro
    Jianfeng Dai
    Institute of Biology and Medical Sciences, Jiangsu Key Laboratory of Infection and Immunity, Soochow University, Suzhou 215123, P R China
    Virol J 8:468. 2011
    b>Dengue virus (DENV) and West Nile virus (WNV), close siblings of the Flaviviridae family, are the causative agents of Dengue hemorraghic shock or West Nile meningoencephalitis respectively...
  46. pmc High-content assay to identify inhibitors of dengue virus infection
    David Shum
    HTS Core Facility, Molecular Pharmacology and Chemistry Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    Assay Drug Dev Technol 8:553-70. 2010
    b>Dengue virus (DENV) infections are vectored by mosquitoes and constitute one of the most prevalent infectious diseases in many parts of the world, affecting millions of people annually...
  47. pmc Dengue virus pathogenesis: an integrated view
    Byron E E Martina
    Erasmus Medical Center, Department of Virology, Rotterdam, The Netherlands
    Clin Microbiol Rev 22:564-81. 2009
    Much remains to be learned about the pathogenesis of the different manifestations of dengue virus (DENV) infections in humans...
  48. pmc A protective role for dengue virus-specific CD8+ T cells
    Lauren E Yauch
    Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    J Immunol 182:4865-73. 2009
    Infection with one of the four serotypes of dengue virus (DENV1-4) can result in a range of clinical manifestations in humans, from dengue fever to the more serious dengue hemorrhagic fever/dengue shock syndrome...
  49. pmc Comparison of dengue virus type 2-specific small RNAs from RNA interference-competent and -incompetent mosquito cells
    Jaclyn C Scott
    Arthropod Borne and Infectious Diseases Laboratory, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, USA
    PLoS Negl Trop Dis 4:e848. 2010
    ..Using deep sequencing technology, we characterized dengue virus type 2 (DENV2)-specific small RNAs produced during infection of Aedes aegypti mosquitoes and A...
  50. pmc Monoclonal antibodies that bind to domain III of dengue virus E glycoprotein are the most efficient blockers of virus adsorption to Vero cells
    W D Crill
    Arbovirus Disease Branch, Division of Vector Borne Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U S Department of Health and Human Services, Fort Collins, Colorado 80522, USA
    J Virol 75:7769-73. 2001
    ..These results extend our understanding of the structure-function relationships in the E glycoprotein of DEN virus and provide the first direct evidence that domain III encodes the primary flavivirus receptor-binding motif...
  51. ncbi The pathogenesis of dengue
    Jamie Whitehorn
    Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Viet Nam
    Vaccine 29:7221-8. 2011
    ..This review summarises recent developments in the understanding of dengue pathogenesis and their relevance to dengue vaccine development...
  52. pmc Spatial evaluation and modeling of Dengue seroprevalence and vector density in Rio de Janeiro, Brazil
    Nildimar Alves Honorio
    Laboratório de Transmissores de Hematozoários, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, Brasil
    PLoS Negl Trop Dis 3:e545. 2009
    ..We analyzed individual and spatial factors associated with seroprevalence using Generalized Additive Model (GAM)...
  53. pmc Dengue--how best to classify it
    Anon Srikiatkhachorn
    Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Clin Infect Dis 53:563-7. 2011
    Dengue has emerged as a major public health problem worldwide. Dengue virus infection causes a wide range of clinical manifestations...
  54. pmc Kinetics of plasma viremia and soluble nonstructural protein 1 concentrations in dengue: differential effects according to serotype and immune status
    Huynh T L Duyen
    Oxford University Clinical Research Unit, Churchill Hospital, Oxford, UK
    J Infect Dis 203:1292-300. 2011
    ..All children recovered fully, and only 5 required hospitalization. Among those with dengue virus type 1 (DENV-1), plasma viremia was significantly greater in primary (49) than secondary (44) infections and ..
  55. pmc Dengue virus capsid protein usurps lipid droplets for viral particle formation
    Marcelo M Samsa
    Fundación Instituto Leloir CONICET, Buenos Aires, Argentina
    PLoS Pathog 5:e1000632. 2009
    b>Dengue virus is responsible for the highest rates of disease and mortality among the members of the Flavivirus genus. Dengue epidemics are still occurring around the world, indicating an urgent need of prophylactic vaccines and antivirals...
  56. pmc High-resolution analysis of intrahost genetic diversity in dengue virus serotype 1 infection identifies mixed infections
    Khoa T D Thai
    Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
    J Virol 86:835-43. 2012
    Little is known about the rate at which genetic variation is generated within intrahost populations of dengue virus (DENV) and what implications this diversity has for dengue pathogenesis, disease severity, and host immunity...
  57. ncbi Validation of an internally controlled one-step real-time multiplex RT-PCR assay for the detection and quantitation of dengue virus RNA in plasma
    Kien Duong Thi Hue
    Oxford University Clinical Research Unit, Hospital for Tropical Diseases, 190 Ben Ham Tu, Quan 5, Ho Chi Minh City, Viet Nam
    J Virol Methods 177:168-73. 2011
    ..5 and 3 infectious particles per mL, is rapid and has been operationally characterized in 287 Vietnamese dengue patients from two therapeutic intervention trials at the Hospital for Tropical Diseases, Ho Chi Minh City, Viet Nam...
  58. pmc Recent advances in deciphering viral and host determinants of dengue virus replication and pathogenesis
    Karen Clyde
    Division of Infectious Diseases, School of Public Health, 140 Warren Hall, University of California, Berkeley, Berkeley, CA 94720 7360, USA
    J Virol 80:11418-31. 2006
  59. ncbi Neurological manifestations of dengue infection
    T Solomon
    Wellcome Trust Clinical Research Unit, Cho Quan Hospital, Ho Chi Minh City, Vietnam
    Lancet 355:1053-9. 2000
    ..Severe forms of dengue, the most important arboviral infection of man, are associated with haemorrhagic disease and a generalised vascular leak syndrome. The importance of dengue as a cause of neurological disease is uncertain...
  60. pmc Dengue virus type 2: replication and tropisms in orally infected Aedes aegypti mosquitoes
    Ma Isabel Salazar
    Arthropod Borne and Infectious Diseases Laboratory, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado 80523 1692, USA
    BMC Microbiol 7:9. 2007
    To be transmitted by its mosquito vector, dengue virus (DENV) must infect midgut epithelial cells, replicate and disseminate into the hemocoel, and finally infect the salivary glands, which is essential for transmission...
  61. pmc Discovery of insect and human dengue virus host factors
    October M Sessions
    Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nature 458:1047-50. 2009
    ..This screen identified 116 candidate dengue virus host factors (DVHFs)...
  62. pmc Inhibition of the type I interferon response in human dendritic cells by dengue virus infection requires a catalytically active NS2B3 complex
    Juan R Rodriguez-Madoz
    Department of Microbiology, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1124, New York, NY 10029, USA
    J Virol 84:9760-74. 2010
    b>Dengue virus (DENV) is the most prevalent arthropod-borne human virus, able to infect and replicate in human dendritic cells (DCs), inducing their activation and the production of proinflammatory cytokines...
  63. pmc Dengue incidence in urban and rural Cambodia: results from population-based active fever surveillance, 2006-2008
    Sirenda Vong
    Institut Pasteur Cambodia, Phnom Penh, Cambodia
    PLoS Negl Trop Dis 4:e903. 2010
    ..To estimate the true burden of dengue in the largest province of Cambodia, Kampong Cham, we conducted community-based active dengue fever surveillance among the 0-to-19-year age group in rural villages and urban areas during 2006-2008...
  64. pmc Enzyme-linked immunosorbent assay specific to Dengue virus type 1 nonstructural protein NS1 reveals circulation of the antigen in the blood during the acute phase of disease in patients experiencing primary or secondary infections
    Sophie Alcon
    Unité des Arbovirus et Virus des Fièvres Hémorragiques, Institut Pasteur, 75724 Paris Cedex 15, France
    J Clin Microbiol 40:376-81. 2002
    ..vivo, we developed a sensitive enzyme-linked immunosorbent assay (ELISA) to detect the protein in the sera of dengue virus-infected patients...
  65. pmc Inhibition of interferon signaling by dengue virus
    Jorge L Munoz-Jordan
    Department of Microbiology, Mount Sinai School of Medicine, One Gustave Levy Place, New York, NY 10029
    Proc Natl Acad Sci U S A 100:14333-8. 2003
    b>Dengue virus is a worldwide-distributed mosquito-borne flavivirus with a positive strand RNA genome. Its transcribed polyprotein is cleaved by host- and virus-encoded peptidases into 10 proteins, some of which are of unknown function...
  66. ncbi Geographic expansion of dengue: the impact of international travel
    Annelies Wilder-Smith
    Department of Medicine, Travelers Screening and Vaccination Clinic, National University Hospital of Singapore, National University of Singapore, 5, Lower Kent Ridge, Singapore 119074
    Med Clin North Am 92:1377-90, x. 2008
    ..Epidemics of dengue, their seasonality, and oscillations over time are reflected by the epidemiology of dengue in travelers. Sentinel surveillance of travelers could augment existing national public health surveillance systems...
  67. pmc Dengue virus neutralization by human immune sera: role of envelope protein domain III-reactive antibody
    W M P B Wahala
    Department of Microbiology and Immunology, CB 7290 University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
    Virology 392:103-13. 2009
    ..Our results have implications for understanding protective immunity following natural DENV infection and for evaluating DENV vaccines...
  68. pmc In-depth analysis of the antibody response of individuals exposed to primary dengue virus infection
    Ruklanthi de Alwis
    Department of Microbiology and Immunology, and the Southeast Regional Center of Excellence for Biodefense and Emerging Infectious Diseases Research, University of North Carolina School of Medicine, Chapel Hill, NC, USA
    PLoS Negl Trop Dis 5:e1188. 2011
    Humans who experience a primary dengue virus (DENV) infection develop antibodies that preferentially neutralize the homologous serotype responsible for infection...
  69. pmc The development of therapeutic antibodies that neutralize homologous and heterologous genotypes of dengue virus type 1
    Bimmi Shrestha
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS Pathog 6:e1000823. 2010
    ..Overall, our experiments define a complex structural epitope on DIII of DENV-1 that can be recognized by protective antibodies with therapeutic potential...
  70. pmc Clinical and virological features of Dengue in Vietnamese infants
    Tran Nguyen Bich Chau
    Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
    PLoS Negl Trop Dis 4:e657. 2010
    ..The clinical and laboratory features in infants with dengue have not been extensively characterised...
  71. ncbi Progress towards a dengue vaccine
    Daniel P Webster
    Department of Infectious Diseases and Microbiology, John Radcliffe Hospital, Oxford, UK
    Lancet Infect Dis 9:678-87. 2009
    The spread of dengue virus throughout the tropics represents a major, rapidly growing public health problem with an estimated 2.5 billion people at risk of dengue fever and the life-threatening disease, severe dengue...
  72. pmc Enhanced infection of liver sinusoidal endothelial cells in a mouse model of antibody-induced severe dengue disease
    Raphaël M Zellweger
    La Jolla Institute for Allergy and Immunology, CA 92037, USA
    Cell Host Microbe 7:128-39. 2010
    b>Dengue virus (DENV) causes disease ranging from dengue fever (DF), a self-limited febrile illness, to the potentially lethal dengue hemorrhagic fever and dengue shock syndrome (DHF/DSS)...
  73. pmc Development of a recombinant tetravalent dengue virus vaccine: immunogenicity and efficacy studies in mice and monkeys
    David E Clements
    Hawaii Biotech, Inc, 99 193 Aiea Heights Drive, Aiea, HI 96701, United States
    Vaccine 28:2705-15. 2010
    Truncated recombinant dengue virus envelope protein subunits (80E) are efficiently expressed using the Drosophila Schneider-2 (S2) cell expression system...
  74. ncbi Autophagic machinery activated by dengue virus enhances virus replication
    Ying Ray Lee
    Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    Virology 374:240-8. 2008
    ..We unravel that Dengue virus-2 (DV2) can trigger autophagic process in various infected cell lines demonstrated by GFP-LC3 dot formation and ..
  75. ncbi Clinical, epidemiologic, and virologic features of dengue in the 1998 epidemic in Nicaragua
    E Harris
    Division of Infectious Diseases, School of Public Health, University of California, Berkeley 94720 7360, USA
    Am J Trop Med Hyg 63:5-11. 2000
    ..As evidenced by the analysis of this epidemic, the epidemiology of dengue can differ according to geographic region and viral serotype...
  76. pmc Structure and function analysis of therapeutic monoclonal antibodies against dengue virus type 2
    Soila Sukupolvi-Petty
    Department of Medicine, Washington University School of Medicine, 660 South Euclid Ave, Box 8051, St Louis, MO 63110, USA
    J Virol 84:9227-39. 2010
    b>Dengue virus (DENV) is the most prevalent insect-transmitted viral disease in humans globally, and currently no specific therapy or vaccine is available...
  77. ncbi Serotype-specific differences in clinical manifestations of dengue
    Angel Balmaseda
    Departamento de Virologia, Centro Nacional de Diagnostico y Referencia, Ministerio de Salud, Managua, Nicaragua
    Am J Trop Med Hyg 74:449-56. 2006
    Dengue, the most prevalent arthropod-borne viral disease of humans, is caused by four serotypes of dengue virus (DENV 1-4)...
  78. pmc Emergence of the Asian 1 genotype of dengue virus serotype 2 in viet nam: in vivo fitness advantage and lineage replacement in South-East Asia
    Thi Ty Hang Vu
    Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Viet Nam
    PLoS Negl Trop Dis 4:e757. 2010
    A better description of the extent and structure of genetic diversity in dengue virus (DENV) in endemic settings is central to its eventual control...
  79. ncbi Emerging flaviviruses: the spread and resurgence of Japanese encephalitis, West Nile and dengue viruses
    John S Mackenzie
    Australian Biosecurity Cooperative Research Centre, Curtin University of Technology, Perth, Western Australia
    Nat Med 10:S98-109. 2004
    ....
  80. pmc Heat shock protein 90 and heat shock protein 70 are components of dengue virus receptor complex in human cells
    Jorge Reyes-Del Valle
    Departamento de Patologia Experimental, Centro de Investigacion y de Estudios Avanzados del IPN, Av I P N 2508, Col San Pedro Zacatenco, Mexico City D F, C P 07360, Mexico
    J Virol 79:4557-67. 2005
    b>Dengue virus requires the presence of an unidentified cellular receptor on the surface of the host cell...
  81. pmc The mannose receptor mediates dengue virus infection of macrophages
    Joanna L Miller
    Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom
    PLoS Pathog 4:e17. 2008
    Macrophages (MØ) and mononuclear phagocytes are major targets of infection by dengue virus (DV), a mosquito-borne flavivirus that can cause haemorrhagic fever in humans...
  82. pmc Spatial and temporal clustering of dengue virus transmission in Thai villages
    Mammen P Mammen
    Department of Virology, Armed Forces Research Institute of Medical Sciences AFRIMS, Bangkok, Thailand
    PLoS Med 5:e205. 2008
    ..To test the hypothesis that DENV transmission is spatially and temporally focal, we compared geographic and temporal characteristics within Thai villages where DENV are and are not being actively transmitted...
  83. pmc Flavivirus activates phosphatidylinositol 3-kinase signaling to block caspase-dependent apoptotic cell death at the early stage of virus infection
    Chyan Jang Lee
    Graduate Institute of Life Sciences, Taipei, Taiwan, Republic of China
    J Virol 79:8388-99. 2005
    Flaviviruses such as dengue virus (DEN) and Japanese encephalitis virus (JEV) are medically important in humans...
  84. ncbi Identification of a recombinant dengue virus type 1 with 3 recombination regions in natural populations in Guangdong province, China
    S P Chen
    State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, No 20 Dongdajie Street, Fengtai District, Beijing 100071, China
    Arch Virol 153:1175-9. 2008
    Using recombination analysis, we identified a recombinant dengue virus type 1 strain, namely, GD23/95, with three recombination regions, located within the sequences of the prM/E junction, NS1, and NS3, respectively...
  85. pmc A mouse-passaged dengue virus strain with reduced affinity for heparan sulfate causes severe disease in mice by establishing increased systemic viral loads
    Tyler R Prestwood
    Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, California 92037, USA
    J Virol 82:8411-21. 2008
    The four serotypes of dengue virus (DENV1 to DENV4) cause extensive morbidity and mortality. A major obstacle to studying disease pathogenesis and developing therapies has been the lack of a small-animal model...
  86. ncbi Serotype-specific dengue virus circulation and dengue disease in Bangkok, Thailand from 1973 to 1999
    Ananda Nisalak
    Department of Virology, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand
    Am J Trop Med Hyg 68:191-202. 2003
    b>Dengue virus circulation and association with epidemics and severe dengue disease were studied in hospitalized children with suspected dengue at the Queen Sirikit National Institute of Child Health in Bangkok, Thailand, from 1973 to 1999...
  87. pmc Structural and functional studies of the promoter element for dengue virus RNA replication
    Maria F Lodeiro
    Fundacion Instituto Leloir, Buenos Aires, Argentina
    J Virol 83:993-1008. 2009
    The 5' untranslated region (5'UTR) of the dengue virus (DENV) genome contains two defined elements essential for viral replication. At the 5' end, a large stem-loop (SLA) structure functions as the promoter for viral polymerase activity...
  88. pmc Serotype-specific differences in the risk of dengue hemorrhagic fever: an analysis of data collected in Bangkok, Thailand from 1994 to 2006
    Jessica R Fried
    Mahidol Oxford Tropical Medicine Research Unit MORU, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    PLoS Negl Trop Dis 4:e617. 2010
    ..It is unclear whether dengue serotypes differ in their propensity to cause severe disease. We analyzed differences in serotype-specific disease severity in children presenting for medical attention in Bangkok, Thailand...
  89. pmc NS5 of dengue virus mediates STAT2 binding and degradation
    Joseph Ashour
    Department of Microbiology, Emerging Pathogens Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Virol 83:5408-18. 2009
    ..b>Dengue virus (DENV) encodes several proteins (NS2a, NS4a, and NS4b) that have been shown individually to inhibit the IFN ..
  90. pmc Seroprevalence and risk factors for dengue infection in socio-economically distinct areas of Recife, Brazil
    Cynthia Braga
    Centro de Pesquisas Aggeu Magalhaes, Fundacao Oswaldo Cruz, Av Professor Moraes Rego, S N, Cidade Universitaria, CEP 50670 420, Recife, PE, Brazil
    Acta Trop 113:234-40. 2010
    ..In the deprived area, 59% of children had already been exposed to dengue virus by the age of 5 years and the estimated force of infection was three times higher than that in the privileged ..
  91. pmc Serotype-specific detection of dengue viruses in a fourplex real-time reverse transcriptase PCR assay
    Barbara W Johnson
    Diagnostic and Reference Laboratory, Arbovirus Diseases Branch, Division of Vector Borne Infectious Diseases, Centers for Disease Control and Prevention, 3150 Rampart Rd, Fort, Collins, CO 80521
    J Clin Microbiol 43:4977-83. 2005
    ....
  92. pmc An antigen capture enzyme-linked immunosorbent assay reveals high levels of the dengue virus protein NS1 in the sera of infected patients
    P R Young
    Sir Albert Sakzewski Virus Research Centre, The Royal Children s Hospital, Herston, Brisbane 4029, Australia
    J Clin Microbiol 38:1053-7. 2000
    We describe the development of a capture enzyme-linked immunosorbent assay for the detection of the dengue virus nonstructural protein NS1...
  93. ncbi Identification of GRP 78 (BiP) as a liver cell expressed receptor element for dengue virus serotype 2
    S Jindadamrongwech
    Molecular Pathology Laboratory, Institute of Molecular Biology and Genetics, Mahidol University, Nakorn Pathom, Thailand
    Arch Virol 149:915-27. 2004
    This study sought to identify receptor elements for dengue virus serotype 2 on human liver cells (HepG2) using the viral overlay protein binding assay (VOPBA) technique and Mass Spectrometry fingerprinting...
  94. ncbi Flavivirus induces interferon-beta gene expression through a pathway involving RIG-I-dependent IRF-3 and PI3K-dependent NF-kappaB activation
    Tsung Hsien Chang
    Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan, ROC
    Microbes Infect 8:157-71. 2006
    In this study, we found that infection with flaviviruses, such as Japanese encephalitis virus (JEV) and dengue virus serotype 2 (DEN-2), leads to interferon-beta (IFN-beta) gene expression in a virus-replication- and de novo protein-..
  95. ncbi Dendritic cell-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN)-mediated enhancement of dengue virus infection is independent of DC-SIGN internalization signals
    Pierre Yves Lozach
    Unite d Immunologie Virale, Institut Pasteur Paris, 25 28, rue du Dr Roux, 75724 Paris Cedex 15, France
    J Biol Chem 280:23698-708. 2005
    b>Dengue virus (DV) is a mosquito-borne flavivirus that causes hemorrhagic fever in humans...
  96. ncbi Pathogenesis of flavivirus infections: using and abusing the host cell
    Maria Dolores Fernandez-Garcia
    Unité Pathogénie Virale, INSERM U819, Institut Pasteur, Departement de Virologie, Paris, France
    Cell Host Microbe 5:318-28. 2009
    Flaviviruses, such as the dengue virus and the West Nile virus, are emerging arthropod-borne viruses that represent an immense global health problem...
  97. ncbi Cytokine cascade in dengue hemorrhagic fever: implications for pathogenesis
    U C Chaturvedi
    Department of Microbiology, Faculty of Medicine, Kuwait University, Safat, Kuwait
    FEMS Immunol Med Microbiol 28:183-8. 2000
    b>Dengue virus produces a mild acute febrile illness, dengue fever (DF) and a severe illness, dengue hemorrhagic fever (DHF)...
  98. ncbi Human TLR3 recognizes dengue virus and modulates viral replication in vitro
    Yi Ting Tsai
    Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan
    Cell Microbiol 11:604-15. 2009
    ..This study aims at the interaction between dengue virus (DENV) and human TLRs at the incipient stage of infection in vitro...
  99. pmc Dengue-virus-infected dendritic cells trigger vascular leakage through metalloproteinase overproduction
    Natthanej Luplertlop
    Institut de Recherche pour le Developpement, IRD, Immunologie Virale et Moléculaire, UR178 IFR122, 34094 Montpellier, France
    EMBO Rep 7:1176-81. 2006
    b>Dengue virus (DV) is an important re-emerging arthropod-borne virus of global significance...
  100. ncbi Inferring the rate and time-scale of dengue virus evolution
    S Susanna Twiddy
    Department of Zoology, University of Oxford, Oxford, United Kingdom
    Mol Biol Evol 20:122-9. 2003
    ..To understand the rate at which genetic diversification occurs in dengue virus and to infer the time-scale of its evolution, we employed a maximum likelihood method that uses information ..
  101. ncbi Translation elongation factor-1alpha, La, and PTB interact with the 3' untranslated region of dengue 4 virus RNA
    Monica De Nova-Ocampo
    Departamento de Biomedicina Molecular, Centro de Investigacion y de Estudios Avanzados del IPN, Mexico City 07360, Mexico
    Virology 295:337-47. 2002
    ..The latter are duplicated (CS2A and CS2B) in DEN4. Dengue virus replication, like that of other RNA viruses, might involve the cis-elements located within the 3'UTR and the ..

Research Grants79

  1. Dengue Epitope Vaccine,Tetravalent & MHCII-Targeted
    J Thomas August; Fiscal Year: 2007
    ..The vaccine constructs will be validated for human dengue virus specific T- and B-cell responses by the human ex vivo assay system (Project 2), and by mouse immunization for ..
  2. Dengue Infected Endothelial Cells Enhance Immune Cell Activation
    Erich R Mackow; Fiscal Year: 2013
    ..DF), dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS) are diseases caused by 4 serotypes of dengue virus (DV)...
  3. Development of a Recombinant Tetravalent Dengue Vaccine Based on a Subunit Envelo
    Lynda G Tussey; Fiscal Year: 2013
    ..response to all four serotypes of dengue viruses (DENV-1 to -4) because sequential infection by different dengue virus serotypes can lead to life-threatening dengue hemorrhagic fever or dengue shock syndrome...
  4. Fatty Acid Synthase Inhibitors As Broad Spectrum Anti-Flaviviral Therapeutics
    Glenn Randall; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Dengue virus (DENV) is the most clinically important arbovirus and a Category A bioterrorism agent...
  5. Preventing lethal hemorrhagic fever caused by hantaviruses by preserving endothel
    ALAN L MUELLER; Fiscal Year: 2012
    ..g. Ebola virus, Lassa fever virus, Dengue virus, etc.)...
  6. DC-SIGN Inhibitors for the Treatment of HIV Infection
    ALLEN BERNARD REITZ; Fiscal Year: 2013
    ..cell receptor for human immunodeficiency virus (HIV-1 and HIV-2), simian immunodeficiency virus (SIV), dengue virus, Marburg virus, hepatitis C, Ebola, and cytomegalovirus...
  7. Antiviral potential of helicase inhibitors
    David N Frick; Fiscal Year: 2012
    ..RNA viruses, focusing on pathogens with abnormally high global burdens of disease: hepatitis C virus (HCV), Dengue virus (DENV), West Nile virus (WNV), Japanese encephalitis virus (JEV), yellow fever virus (YFV), and human ..
  8. Alternative regulation of ISGs in WNV-infected cells
    Margo A Brinton; Fiscal Year: 2013
    ..flaviviruses, including West Nile virus (WNV), Japanese encephalitis virus, tick- borne encephalitis virus and dengue virus, are significant human pathogens...
  9. Insulin, IGF and Insulin Signaling: effects on Anopheles lifespan and immunity
    MICHAEL ALLEN RIEHLE; Fiscal Year: 2012
    ..Relevance: Many mosquito-borne disease agents, including malaria parasites, dengue virus, and West Nile virus, must develop in mosquitoes for extended periods before being transmitted to humans...
  10. Key determinants of dengue virus neutralization by naturally occurring human mAbs
    Scott A Smith; Fiscal Year: 2013
    ..This information is of timely importance, as it is needed for the rational design of an effective dengue virus vaccine...
  11. Mosquito Saliva in Dengue Virus Pathogenesis
    REBECCA R RICO-HESSE; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Mosquito Saliva in Dengue Virus Pathogenesis. Dengue virus is a single-stranded RNA Flavivirus that causes dengue fever (DF), the most prevalent arthropod-borne viral illness in humans...
  12. Malaria vaccines modified with TLR agonist adjuvant
    Elizabeth H Nardin; Fiscal Year: 2010
    ..currently in clinical trial) and flaviviruses such as West Nile virus, Japanese encephalitis virus, and Dengue virus by VaxInnate...
  13. Fitness and Virulence of Dengue Virus in the Context of Changing Host Immunity
    Eva Harris; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Four serotypes of dengue virus (DENV-1-4) that circulate globally, causing more human illness than any other arthropod-borne virus...
  14. The Mechanisms of IFITM-Mediated Restriction
    I Chueh Huang; Fiscal Year: 2013
    ..IFITM) proteins critical to the interferon-mediated control of several pathogenic viruses, including IAV, dengue virus and West Nile virus...
  15. The role of the host Ca/Mn pump in emergence of novel viral RNA recombinants
    Peter Nagy; Fiscal Year: 2010
    ..the similarity of TBSV replicase proteins to proteins of important pathogens, such as Hepatitis C virus (HCV), dengue virus, West Nile virus and other Flaviviruses and Pestiviruses...
  16. Rational Development of Candidate Attenuated Flavivirus Vaccines
    Tian Wang; Fiscal Year: 2013
    ..provided by applicant): The flaviviruses contain many pathogens of public health importance, including dengue virus (DENV) and West Nile virus (WNV) for which we have no licensed vaccines...
  17. Mechanism of RNA synthesis and 5'-capping by dengue virus NS5 polymerase
    Kyung H Choi; Fiscal Year: 2013
    ..In Aim 1, the interactions of the RdRp and MTase domains within dengue virus NS5 and the conformational changes that occur therein during the polymerase and methylation reactions, will be ..
  18. Novel Tetravalent Vaccines for Dengue Virus
    ROBERT GERALD WHALEN; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Dengue virus infection is an emerging disease and an expanding global health problem...
  19. Role of innate immunity in responding to an alphavirus-based adjuvant
    Benjamin P Steil; Fiscal Year: 2010
    ..such as nVRPs) that can improve both existing and new vaccines to diseases such as tuberculosis, HIV, dengue virus and hepatitis C virus...
  20. MMDx: A rapid multiplexed matrix code diagnostic for real time epidemiology
    Lee Gehrke; Fiscal Year: 2013
    ..The prototype will offer 1) direct identification of the four different dengue virus serotypes by detecting circulating viral protein NS1, as well as 2) indirect Ebola virus and dengue virus ..
  21. Examining Human Behavior in Dengue Prevention Efforts in Iquitos, Peru
    VALERIE ANDREA PAZ-SOLDAN; Fiscal Year: 2013
    ..Scott et al.'s NIH-funded grant designed to test the hypothesis that spatial dimensions of dengue virus transmission are defined by daily patterns of human movement in Iquitos, Peru;2) to assess the role of human ..
  22. A new synergy for flavivirus therapy: RNAi enhancement and viral mutagens
    KATHRYN ALYCE HANLEY; Fiscal Year: 2012
    ..will test the hypothesis that enhancing RNAi will amplify the effect of mutagenic nucleoside analogs on dengue virus mutation rate and replication, and that the synergistic effect of RNAi enhancement will accelerate lethal ..
  23. Nanocapsule-mediated topical delivery of VLP-generating Dengue DNA vaccine
    Gretchen M Unger; Fiscal Year: 2013
    ..by applicant): The ultimate goal of this project is to develop a safe and effective topical vaccine against the dengue virus (DENV)...
  24. Regulation of reovirus induced apoptosis
    John S Parker; Fiscal Year: 2012
    ..Many pathogenic human viruses, e.g., dengue virus, influenza virus, and West Nile virus, cause disease by inducing apoptosis...
  25. Dengue Virus Genome Encapsidation and Its Interplay with Host Lipid Droplets
    Andrea Gamarnik; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Dengue virus, a member of the Flaviviridae family, is a Category A pathogen that causes the most prevalent arthropod-borne viral illnesses in humans...
  26. Metagenomic detection of emerging viruses in the blood supply
    Eric L Delwart; Fiscal Year: 2013
    ..we will analyze 2000 plasma specimens collected from blood donors in Honduras and Brazil during outbreaks of dengue virus and from 200 WNV RNA+ blood donors from the US...
  27. Broad Detection of Infectious Agents in Blood by Microarrays and Deep Sequencing
    CHARLES YEN CHIU; Fiscal Year: 2013
    ..with the most common bloodborne infections, including malaria, Chagas disease, HIV, hepatitis B/C, and dengue virus. The expanded Virochip and deep sequencing will then be used to launch a broad- spectrum surveillance program ..
  28. Dengue diagnostics using a novel peroxidase chain reaction (PxCR)
    PETER PETER ZASSENHAUS; Fiscal Year: 2013
    ..In this proposal we focus on using PxCR to develop diagnostics for dengue virus. The Specific Aims are to: (1) Develop pan and serotype specific PxCR assays for dengue viral RNA using ..
  29. Role of TRIM79 in innate immunity to tick-borne encephalitis virus
    ROGER TRAVIS TAYLOR; Fiscal Year: 2013
    ..The flaviviruses represent a tremendous disease burden to humans, including dengue virus, West Nile virus (WNV) and tick-borne encephalitis virus (TBEV)...
  30. MODULATION OF INNATE AND ADAPTIVE IMMUNITY BY DENGUE VIRUS
    Ana Fernandez-Sesma; Fiscal Year: 2012
    b>Dengue virus (DenV) is a devastating human pathogen that causes disease and viremia in millions of people worldwide every year. But very little is known about the initiation of immunity by DenV...
  31. Genetic dissection of the RNAi-mediated antiviral immunity in C. elegans
    Shou Wei Ding; Fiscal Year: 2013
    ..Many RNA viruses such as influenza, hepatitis C virus, poliovirus, dengue virus and West Nile virus are important human pathogens...
  32. Validation of Src kinases as Anti-Dengue Viral Targets
    PRISCILLA LI NING YANG; Fiscal Year: 2012
    b>Dengue virus (DENV) is the most important mosquito-borne viral disease affecting humans today, with an estimated 2.5 billion living in areas at risk for epidemic transmission...
  33. Development of a Novel, Chimeric Chikungunya Vaccine
    Richard Kinney; Fiscal Year: 2009
    ..Like dengue virus, CHIKV uses humans as amplifying hosts and therefore can disseminate readily in travelers, suggesting that it ..
  34. A Study of Heterologous Immunity Induced by Neonatal BCG Vaccination
    Daniel H Libraty; Fiscal Year: 2012
    ..cells (PBMC) and plasma samples that have been collected as part of an ongoing prospective clinical study of dengue virus infections during infancy...
  35. Altered peptide ligands and immunopathogenesis of dengue virus infection
    ALLISON ANNE IMRIE; Fiscal Year: 2010
    ..in the human response to primary and sequential dengue infection, testing the overarching hypothesis that dengue virus (DV)-specific memory T cells may be preferentially activated by altered peptide ligands (APL) representing ..
  36. Functional role of a host metabolic enzyme in viral replication
    Peter Nagy; Fiscal Year: 2010
    ..the similarity of TBSV replicase proteins to proteins of important pathogens, such as Hepatitis C virus (HCV), dengue virus, West Nile virus and other Flaviviruses and Pestiviruses...
  37. Chimeric Alphavirus Vaccines for Chikungunya
    Scott C Weaver; Fiscal Year: 2010
    ..Like dengue virus, CHIKV uses humans as amplifying hosts and therefore can disseminate readily in travelers, suggesting that it ..
  38. Does Dengue Virus Suppress RNA Interference in its Mosquito Vector?
    KATHRYN ALYCE HANLEY; Fiscal Year: 2010
    ..Vaccines are needed for many flaviviruses, particularly dengue virus, and mutations that disable VSR's may contribute to attenuation of vaccine candidates...
  39. Methyltransferase inhibition assay development
    Bernard Weisblum; Fiscal Year: 2010
    ..In the proposed studies, a Dengue virus-encoded cap-methyltransferase will be used as a model enzyme target that converts the partially methylated to ..
  40. Inhibiting Cellular Autophagy to Thwart Dengue Virus Packaging and Replication
    Karla Kirkegaard; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Dengue virus, a category A pathogen, infects 40-100 million people each year...
  41. ISG CONTROL OF FLAVIVIRUS INFECTION
    Michael S Diamond; Fiscal Year: 2013
    ..This genus includes viruses (West Nile virus (WNV), Japanese encephalitis virus (JEV) and Dengue virus (DENV)) that are re-emerging and becoming endemic in new areas of the world...
  42. Sustainable Control of Aedes aegypti and epidemic dengue
    Lars Eisen; Fiscal Year: 2013
    ..Current control measures used against the primary dengue virus (DENV) mosquito vector, Aedes aegypti, include source reduction to control juveniles and space spraying to ..
  43. Determinants of protection and enhancement of dengue infection/disease in vivo
    Eva Harris; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Four serotypes of dengue virus (DENV1-4) circulate globally, causing more human illness than any other arthropod-borne virus...
  44. The Role of RNA Interference in West Nile Virus Diversification
    Douglas E Brackney; Fiscal Year: 2010
    ..and chikungunya virus (CHIKV) in the Eastern hemisphere highlight the potential for other arbovirus such as dengue virus (DENV) and Rift Valley fever virus (RVFV) to emerge in non-endemic regions...
  45. Mechanism of inhibition of +RNA virus replication by cyclophilins
    Peter Nagy; Fiscal Year: 2012
    ..knowledge will not only be useful for TBSV, but to other significant human pathogens, such as West Nile virus, Dengue virus and other flaviviruses and pestiviruses, due to the similarity of their replicase proteins...
  46. Genetic approaches to discover host factors critical to dengue virus infection
    JAN EDUARD CARETTE; Fiscal Year: 2012
    ..A detailed understanding of the host functions that determine dengue virus replication and spread may accelerate the development of antiviral drugs...
  47. A Novel Method of Generating Hepatitis C Virus-Like Particles using Lentivirus
    Boro Dropulic; Fiscal Year: 2009
    ..viruses;E1E2 of hepatitis C virus, prM and E of yellow fever virus, prM and E of West Nile virus, E of Dengue virus and HA of influenza virus can all be efficiently pseudotyped onto rVLPs...
  48. Endosymbiont, Arbovirus &Mosquito Interactions and the Disease Control
    Zhiyong Xi; Fiscal Year: 2013
    ..Breaking the link between the mosquito vector and the dengue virus is the best option for protecting people...
  49. Metabolomics-based discovery of small molecule biomarkers for noninvasive dengue
    Barry J Beaty; Fiscal Year: 2013
    ..disease (DEN) in Latin America in the last decade is of grave concern;30% of cases are now diagnosed as severe dengue virus (DENV) infections. DEN is overwhelming public health capacity for clinical care in much of the developing world...
  50. Inhibition and mechanism of flavivirus methyltransferase
    Hongmin Li; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Many flaviviruses such as Dengue virus, West Nile virus, and Yellow Fever virus cause significant human diseases...
  51. Composition, Structure, Dynamics and Function of C-Type Lectin Receptor Domains
    Nancy L Thompson; Fiscal Year: 2013
    ..One such receptor, DC-SIGN, binds to a large variety of pathogens, including dengue virus, HIV and yeasts, by recognizing carbohydrates on the pathogen surfaces...
  52. Subversion of Autophagy Pathway and Constituents by RNA viruses
    Karla Kirkegaard; Fiscal Year: 2013
    ..Several of these viruses, including poliovirus and Dengue virus, mimic or subvert the cellular pathway of autophagy to form double-membraned intracellular compartments...
  53. TAM Receptors and Flavivirus Infection
    GREG E LEMKE; Fiscal Year: 2013
    ..RTKs) of the TAM family - Tyro3, Axl, and Mer - are exploited by flaviviruses, such as West Nile Virus and Dengue Virus, to infect their target cells...
  54. NIH Director's Pioneer Award
    Karla Kirkegaard; Fiscal Year: 2010
    ..drug targets? for other positive-strand viruses such as rhinoviruses, coxsackieviruses, hepatitis C virus, Dengue virus and West Nile virus, informed by analogy with poliovirus and tested by direct genetic and biochemical ..
  55. Therapy of Dengue with Modified Antibodies in Humanized Mice
    REBECCA R RICO-HESSE; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Dengue virus (DV) is a single-stranded RNA Flavivirus that causes dengue fever (DF), the most prevalent arthropod-borne viral illness in humans...
  56. Elucidating the Mechanism of Novel Dengue Antivirals
    Stanley Watowich; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): No antivirals or vaccines exist to combat dengue virus (DENV) infection. This is a serious failing since DENV is a recognized Category A bioterrorist agent. In addition, annually DENV causes about1...
  57. Yellow Fever/Dengue Virus Competence in Aedes aegypt aegypti/formosus in Senegal
    William C Black; Fiscal Year: 2013
    ..l.) is the primary vector to humans of yellow fever virus (YFV) and the four serotypes of dengue virus (DENV1-4)...
  58. Structure and Function of Flaviviruses
    Michael G Rossmann; Fiscal Year: 2013
    ..We have learned to produce purified dengue virus and West Nile virus in milligram quantities of sufficient quality for structural studies...
  59. Tetravalent dengue vaccine based on complex adenovirus vectors
    Kanakatte Raviprakash; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Dengue virus is a category A priority pathogen, as also the most important arbovirus causing human disease...
  60. Innate immune mechanisms in dengue infection
    Kovit Pattanapanyasat; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): One of the most perplexing issues with regards to dengue virus infection is the finding that whereas primary infection with one serotype leads to long term protection against the same serotype, ..
  61. A Clinical Study of Protective and Pathogenic Immunity to Dengue during Infancy
    Daniel H Libraty; Fiscal Year: 2013
    ..The goal of this proposal is to delineate protective and pathogenic human immune responses against dengue virus (DENV) infections in the unique immunological setting of infancy...
  62. Development of an H2O2-Inactivated Dengue Virus Vaccine
    Mark K Slifka; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Dengue virus (DENV) represents an emerging/re-emerging infectious disease that causes significant human morbidity and mortality...
  63. Impacts of Urbanization on Vector Biology and Transmission of Dengue in China
    Xiaoguang Chen; Fiscal Year: 2013
    ..creates favorable conditions for the survival and reproduction of Dengue vectors and for the transmission of Dengue virus. This application tests the central hypothesis that environmental changes resulting from urbanization affect ..
  64. Host factors involved in viral RNA recombination
    Peter Nagy; Fiscal Year: 2006
    ..has been demonstrated to occur for a large number of human, animal and plant viruses, including poliovirus, dengue virus, infectious bronchitis virus, influenza A virus, hantavirus, hepatitis D virus, Human Respiratory Syncytial ..
  65. A HTS Assay for Identifying Anti-Viral Drugs Against Arbovirus Infections
    Qianjun Li; Fiscal Year: 2007
    ..Several recent human and/or animal epidemics are caused by arboviruses, including Dengue virus (DNV) in Asia, West Nile virus (WNV) in North America and Bluetongue virus (BTV) in Europe...
  66. Development of Novel Small Molecule Flavivirus Inhibitors
    ERIC W BARKLIS; Fiscal Year: 2010
    ..of related flaviviruses such as the Japanese encephalitis virus (JEV) and the category A biodefense pathogen Dengue virus (DENV)...
  67. POPULATION GENETICS OF AEDES AEGYPTI IN THE WEST INDIES
    David Severson; Fiscal Year: 1999
    ..aegypti particularly as it relates to mosquito control measures. Ae. aegypti is the host for Dengue virus as well as yellow fever virus...
  68. Role of an essential RNA chaperone in virus replication
    Peter Nagy; Fiscal Year: 2006
    ..numerous other important human and animal viruses (hepatitis C virus, flavivirus, including West Nile virus and dengue virus, pestiviruses) and plant viruses (luteo- and carmoviruses), understanding the mechanism of RNA replication in ..
  69. MOLECULAR BIOLOGY OF POLIOVIRUS RNA REPLICATION
    James Bert Flanegan; Fiscal Year: 2010
    ..RNA viruses that form a large group of important human pathogens include hepatitis C virus, West Nile virus, dengue virus and the SARS-associated coronavirus...
  70. Determinants of RNA virus evolution
    ISABEL NOVELLA; Fiscal Year: 2009
    ..and C viruses, HIV, influenza virus, most of the cold viruses, rabies virus, Ebola virus, West Nile virus, and dengue virus. We face major difficulties in controlling these viral diseases because of the viruses'escape from immune ..
  71. Recombinant antigen assays for Lassa and other arenaviru
    Robert Garry; Fiscal Year: 2005
    ..a deliberate release, and allow the virus used to be distinguished from other hemorrhagic fever viruses such as dengue virus or Ebola virus that may have similar case presentations...
  72. Arbovirus quasispecies-impact of arthropod transmission
    GREGORY EBEL; Fiscal Year: 2004
    ..RNA viruses, such as West Nile virus, Dengue virus, Rift Valley fever virus and Venezuelan Equine Encephalitis virus, exist within each host as a genetically ..
  73. A VEE Replicon-Based Vaccine for Dengue Virus
    Laura White; Fiscal Year: 2006
    b>Dengue virus (DEN), a priority "A" pathogen on the NIH/CDC list of bioterrorism related and emerging pathogens, infects humans causing a spectrum of clinical manifestations including dengue fever, dengue hemorrhagic fever and dengue shock ..
  74. Yeast-Based High-throughput Assays for Proteases of Category A, B, & C Viruses
    Hong Fang; Fiscal Year: 2009
    ..In the proposed studies, we will develop yeast assays for proteases produced by seven RNA viruses: Dengue Virus, West Nile Virus, Japanese Encephalitis Virus, Yellow Fever Virus, Hepatitis A Virus, SARS coronavirus, and ..
  75. Lethal Mutagenesis as an Antiviral Strategy
    Craig Cameron; Fiscal Year: 2007
    ..Establish dengue virus type 2 as a model system for evaluation of lethal mutagenesis by characterizing the mechanism of action of ..
  76. FUNCTIONAL ANALYSIS OF DENGUE VIRUS ANTIGENS NS3 AND NS5
    Radhakrishnan Padmanabhan; Fiscal Year: 2003
    ..To study the mechanism of replication in the absence of virion assembly, a subgenomic dengue virus replicon expressing a readily quantifiable reporter gene product will be constructed. 3...
  77. Broad-Spectrum Therapeutic Human Antibodies for Dengue Virus Infections
    Yorgo Modis; Fiscal Year: 2006
    ..epitopes can prevent and treat infection by several different flaviviruses, including all 4 serotypes of dengue virus and West Nile virus (WNV). Passive immunization is an accepted medical practice to protect against infection...
  78. Invasive Aedes Mosquitoes and Dengue in Brazil
    Leon Philip Lounibos; Fiscal Year: 2010
    ..in the laboratory, stressed Aedes females being more susceptible to infection with and dissemination of dengue virus. A central goal of this project, which is more narrowly focused than a previous submission with Brazilian ..
  79. Apoptosis as an anti-viral response in mosquito midgut
    ROLLIE CLEM; Fiscal Year: 2007
    ..are important vectors for a number of infectious diseases caused by arboviruses including West Nile virus, dengue virus, yellow fever virus, LaCrosse virus, and Venezuelan, eastern and western equine encephalitis viruses...