Genomes and Genes
Summary: A species of the genus FLAVIVIRUS which causes an acute febrile and sometimes hemorrhagic disease in man. Dengue is mosquito-borne and four serotypes are known.
Publications310 found, 100 shown here
- Dengue: a continuing global threatMaria G Guzman
Instituto de Medicina Tropical, Pedro Kouri, PO Box 601, Marianao 13, Ciucad de la Habana, Cuba
Nat Rev Microbiol 8:S7-16. 2010..Illness is produced by any of the four dengue virus serotypes...
- Successful establishment of Wolbachia in Aedes populations to suppress dengue transmissionA A Hoffmann
Bio21 Institute, Department of Genetics, The University of Melbourne, Victoria 3010, Australia
Nature 476:454-7. 2011..These findings demonstrate that Wolbachia-based strategies can be deployed as a practical approach to dengue suppression with potential for area-wide implementation...
- Dengue and dengue hemorrhagic feverD J Gubler
Division of Vector Borne Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado 80522, USA
Clin Microbiol Rev 11:480-96. 1998..A major challenge for public health officials in all tropical areas of the world is to develop and implement sustainable prevention and control programs that will reverse the trend of emergent dengue hemorrhagic fever...
- A Wolbachia symbiont in Aedes aegypti limits infection with dengue, Chikungunya, and PlasmodiumLuciano A Moreira
School of Biological Sciences, The University of Queensland, Brisbane QLD 4072, Australia
Cell 139:1268-78. 2009..We suggest that this Wolbachia-mediated pathogen interference may work synergistically with the life-shortening strategy proposed previously to provide a powerful approach for the control of insect transmitted diseases...
- The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virusAbraham L Brass
Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard Medical School, Charlestown, MA 02129, USA
Cell 139:1243-54. 2009..characterization revealed that the IFITM proteins inhibit the early replication of flaviviruses, including dengue virus and West Nile virus...
- Wolbachia induces reactive oxygen species (ROS)-dependent activation of the Toll pathway to control dengue virus in the mosquito Aedes aegyptiXiaoling Pan
Department of Entomology and Genetics Program, Michigan State University, East Lansing, MI 48824, USA
Proc Natl Acad Sci U S A 109:E23-31. 2012..introduced to nonnative mosquito hosts, Wolbachia induce resistance to a number of human pathogens, including dengue virus (DENV), Plasmodium, and filarial nematodes, but the molecular mechanism involved is unclear...
- Dengue viremia titer, antibody response pattern, and virus serotype correlate with disease severityD W Vaughn
Department of Virus Diseases, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA
J Infect Dis 181:2-9. 2000Viremia titers in serial plasma samples from 168 children with acute dengue virus infection who were enrolled in a prospective study at 2 hospitals in Thailand were examined to determine the role of virus load in the pathogenesis of ..
- Immune response to dengue virus and prospects for a vaccineBrian R Murphy
Laboratory of Infectious Diseases, National Institutes of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA
Annu Rev Immunol 29:587-619. 2011b>Dengue virus (DENV) is a mosquito-borne member of the Flavivirus genus and includes four serotypes (DENV-1, DENV-2, DENV-3, and DENV-4), each of which is capable of causing dengue fever and dengue hemorrhagic fever/dengue shock syndrome...
- DengueScott B Halstead
Supportive Research and Development, Pediatric Dengue Vaccine Initiative, Internal Vaccine Institute, Seoul, South Korea
Lancet 370:1644-52. 2007..Here, I review and discuss data on clinical diagnosis and pathophysiology of vascular permeability and coagulopathy, parenteral treatment of DHF/DSS, and new laboratory tests...
- Global spread and persistence of dengueJennifer L Kyle
Division of Infectious Diseases, School of Public Health, and Graduate Group in Microbiology, University of California, Berkeley, California 94720 7354, USA
Annu Rev Microbiol 62:71-92. 2008..urbanization in tropical and subtropical countries, breeding sites for the mosquitoes that transmit dengue virus have proliferated, and successful vector control has proven problematic...
- Consequences of the expanding global distribution of Aedes albopictus for dengue virus transmissionLouis Lambrechts
Department of Virology, Institut Pasteur, Paris, France
PLoS Negl Trop Dis 4:e646. 2010..of numerous arthropod-borne viruses (arboviruses), including the most prevalent arboviral pathogen of humans, dengue virus (DENV). Ae...
- Impact of daily temperature fluctuations on dengue virus transmission by Aedes aegyptiLouis Lambrechts
Department of Virology, Institut Pasteur, 75724 Paris Cedex 15, France
Proc Natl Acad Sci U S A 108:7460-5. 2011..Here, we show that diurnal temperature range (DTR) affects two important parameters underlying dengue virus (DENV) transmission by Aedes aegypti...
- Critical review of the vector status of Aedes albopictusN G Gratz
Med Vet Entomol 18:215-27. 2004..albopictus in countries endemic for dengue and other arboviruses (e.g. Chikungunya, EEE, Ross River, WNV, LaCrosse and other California group viruses), for which it would be competent and ecologically suited to serve as a bridge vector...
- Cross-reacting antibodies enhance dengue virus infection in humansWanwisa Dejnirattisai
Department of Medicine, Imperial College London, London W12 0NN, UK
Science 328:745-8. 2010b>Dengue virus co-circulates as four serotypes, and sequential infections with more than one serotype are common...
- The human immune response to Dengue virus is dominated by highly cross-reactive antibodies endowed with neutralizing and enhancing activityMartina Beltramello
Institute for Research in Biomedicine, Bellinzona 6500, Switzerland
Cell Host Microbe 8:271-83. 2010Antibodies protect against homologous Dengue virus (DENV) infection but can precipitate severe dengue by promoting heterotypic virus entry via Fcγ receptors (FcγR)...
- The role of human movement in the transmission of vector-borne pathogensSteven T Stoddard
Entomology, University of California, Davis, California, United States of America
PLoS Negl Trop Dis 3:e481. 2009..Here we develop a conceptual model to evaluate the importance of variation in exposure due to individual human movements for pathogen transmission, focusing on mosquito-borne dengue virus.
- The Aedes aegypti toll pathway controls dengue virus infectionZhiyong Xi
W Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States of America
PLoS Pathog 4:e1000098. 2008..gene expression and RNA interference (RNAi)-based reverse genetic analyses, to characterize its response to dengue virus infection in different body compartments...
- From research to phase III: preclinical, industrial and clinical development of the Sanofi Pasteur tetravalent dengue vaccineBruno Guy
Research and Development, Sanofi Pasteur, 69280 Marcy l Etoile, France
Vaccine 29:7229-41. 2011..fever vaccine 17D (YFV 17D) backbone, each expressing the pre-membrane and envelope genes of one of the four dengue virus serotypes...
- RNA interference screen for human genes associated with West Nile virus infectionManoj N Krishnan
Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticutt 06520 8031, USA
Nature 455:242-5. 2008..By extending this study to dengue virus, we show that flaviviruses have both overlapping and unique interaction strategies with host cells...
- Next generation dengue vaccines: a review of candidates in preclinical developmentJulia Schmitz
Initiative for Vaccine Research, World Health Organization, Geneva, Switzerland
Vaccine 29:7276-84. 2011..This review provides an overview of the various technological approaches to dengue vaccine development and specifically focuses on candidates in preclinical development...
- Localization of dengue virus in naturally infected human tissues, by immunohistochemistry and in situ hybridizationKala Jessie
Department of Pathology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
J Infect Dis 189:1411-8. 2004..Positive-strand viral RNA was detected in the same IHC-positive cells found in the spleen and blood-clot samples. The strong, positive ISH signal in these cells indicated a high copy number of viral RNA, suggesting replication...
- Structure of the dengue virus envelope protein after membrane fusionYorgo Modis
Howard Hughes Medical Institute, Children s Hospital and Harvard Medical School, 320 Longwood Avenue, Boston, Massachusetts 02115, USA
Nature 427:313-9. 2004b>Dengue virus enters a host cell when the viral envelope glycoprotein, E, binds to a receptor and responds by conformational rearrangement to the reduced pH of an endosome...
- Structure of dengue virus: implications for flavivirus organization, maturation, and fusionRichard J Kuhn
Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA
Cell 108:717-25. 2002..The structure suggests that flaviviruses, and by analogy also alphaviruses, employ a fusion mechanism in which the distal beta barrels of domain II of the glycoprotein E are inserted into the cellular membrane...
- The endosymbiotic bacterium Wolbachia induces resistance to dengue virus in Aedes aegyptiGuowu Bian
Department of Entomology and Genetics Program, Michigan State University, East Lansing, Michigan, United States of America
PLoS Pathog 6:e1000833. 2010..Given the large overlap in tissue distribution and intracellular localization between Wolbachia and dengue virus in mosquitoes, we conducted experiments to characterize their interactions...
- Dengue virus type 2 infections of Aedes aegypti are modulated by the mosquito's RNA interference pathwayIrma Sanchez-Vargas
Department of Microbiology, Arthropod Borne and Infectious Diseases Laboratory, Colorado State University, Fort Collins, Colorado, United States of America
PLoS Pathog 5:e1000299. 2009..have shown that both innate and adaptive immune defense mechanisms greatly influence the course of human dengue virus (DENV) infections, but little is known about the innate immune response of the mosquito vector Aedes aegypti to ..
- Protective efficacy of the recombinant, live-attenuated, CYD tetravalent dengue vaccine in Thai schoolchildren: a randomised, controlled phase 2b trialArunee Sabchareon
Department of Tropical Pediatrics, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
Lancet 380:1559-67. 2012..Roughly half the world's population live in dengue-endemic countries, but no vaccine is licensed. We investigated the efficacy of a recombinant, live, attenuated tetravalent dengue vaccine...
- Original antigenic sin and apoptosis in the pathogenesis of dengue hemorrhagic feverJuthathip Mongkolsapaya
MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, OX3 9DS, UK
Nat Med 9:921-7. 2003b>Dengue virus presents a growing threat to public health in the developing world...
- Identification of five interferon-induced cellular proteins that inhibit west nile virus and dengue virus infectionsDong Jiang
Drexel Institute for Biotechnology and Virology Research, Department of Microbiology and Immunology, Drexel University College of Medicine, Doylestown, Pennsylvania 18902, USA
J Virol 84:8332-41. 2010..that instigate an antiviral state against two medically important flaviviruses, West Nile virus (WNV) and dengue virus (DENV), we tested 36 ISGs that are commonly induced by IFN-alpha for antiviral activity against the two viruses...
- Immunity to dengue virus: a tale of original antigenic sin and tropical cytokine stormsAlan L Rothman
Institute for Immunology and Informatics and Department of Cell and Molecular Biology, University of Rhode Island, Providence, Rhode Island 02903, USA
Nat Rev Immunol 11:532-43. 2011..The existence of four viral serotypes and the association of prior dengue virus infection with an increased risk for more severe disease have presented significant obstacles to vaccine ..
- Wolbachia-mediated resistance to dengue virus infection and death at the cellular levelFrancesca D Frentiu
School of Biological Sciences, The University of Queensland, Brisbane, Australia
PLoS ONE 5:e13398. 2010Dengue is currently the most important arthropod-borne viral disease of humans. Recent work has shown dengue virus displays limited replication in its primary vector, the mosquito Aedes aegypti, when the insect harbors the endosymbiotic ..
- CLEC5A is critical for dengue-virus-induced lethal diseaseSzu Ting Chen
Department and Institute of Microbiology and Immunology, National Yang Ming University, Taipei 112, Taiwan
Nature 453:672-6. 2008Dengue haemorrhagic fever and dengue shock syndrome, the most severe responses to dengue virus (DV) infection, are characterized by plasma leakage (due to increased vascular permeability) and low platelet counts...
- The origin, emergence and evolutionary genetics of dengue virusEdward C Holmes
Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK
Infect Genet Evol 3:19-28. 2003..Herein we show how the comparative analysis of gene sequence data has shed light on the origin and spread of dengue virus, as well as on the evolutionary processes that structure its genetic diversity...
- Dengue virus-induced autophagy regulates lipid metabolismNicholas S Heaton
Department of Microbiology, The University of Chicago, Chicago, IL 60637, USA
Cell Host Microbe 8:422-32. 2010..However, some viruses, including dengue virus (DENV), usurp autophagy to enhance their replication...
- Prospects for a dengue virus vaccineStephen S Whitehead
Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Nat Rev Microbiol 5:518-28. 2007..A tetravalent vaccine is urgently needed and must be effective against all four dengue virus serotypes, be cost-effective and provide long-term protection...
- DC-SIGN (CD209) mediates dengue virus infection of human dendritic cellsBoonrat Tassaneetrithep
Division of Retrovirology, Walter Reed Army Institite of Research and Henry M Jackson Foundation for the Advancement of Military Medicine Diseases, Rockville, MD 20850, USA
J Exp Med 197:823-9. 2003b>Dengue virus is a single-stranded, enveloped RNA virus that productively infects human dendritic cells (DCs) primarily at the immature stage of their differentiation...
- An evolutionary conserved function of the JAK-STAT pathway in anti-dengue defenseJayme A Souza-Neto
W Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, The Johns Hopkins University, 615 North Wolfe Street E4209, Baltimore, MD 21205, USA
Proc Natl Acad Sci U S A 106:17841-6. 2009Here, we show that the major mosquito vector for dengue virus uses the JAK-STAT pathway to control virus infection. Dengue virus infection in Aedes aegypti mosquitoes activates the JAK-STAT immune signaling pathway...
- Composition and three-dimensional architecture of the dengue virus replication and assembly sitesSonja Welsch
Department of Molecular Virology, University of Heidelberg, Im Neuenheimer Feld 345, Heidelberg D 69120, Germany
Cell Host Microbe 5:365-75. 2009..Using electron microscopy, we find Dengue virus (DENV)-induced vesicles, convoluted membranes, and virus particles to be endoplasmic reticulum (ER)-derived, ..
- Dengue virus infectivity depends on envelope protein binding to target cell heparan sulfateY Chen
Department of Internal Medicine, University of Michigan, Ann Arbor 48109, USA
Nat Med 3:866-71. 1997b>Dengue virus is a human pathogen that has reemerged as an increasingly important public health threat...
- Global cross-talk of genes of the mosquito Aedes aegypti in response to dengue virus infectionSusanta K Behura
Eck Institute for Global Health, Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana, USA
PLoS Negl Trop Dis 5:e1385. 2011The mosquito Aedes aegypti is the primary vector of dengue virus (DENV) infection in humans, and DENV is the most important arbovirus across most of the subtropics and tropics worldwide...
- ISG15 facilitates cellular antiviral response to dengue and west nile virus infection in vitroJianfeng Dai
Institute of Biology and Medical Sciences, Jiangsu Key Laboratory of Infection and Immunity, Soochow University, Suzhou 215123, P R China
Virol J 8:468. 2011b>Dengue virus (DENV) and West Nile virus (WNV), close siblings of the Flaviviridae family, are the causative agents of Dengue hemorraghic shock or West Nile meningoencephalitis respectively...
- Dengue virus nonstructural protein 3 redistributes fatty acid synthase to sites of viral replication and increases cellular fatty acid synthesisNicholas S Heaton
Department of Microbiology, University of Chicago, Chicago, IL 60637, USA
Proc Natl Acad Sci U S A 107:17345-50. 2010b>Dengue virus (DENV) modifies cellular membranes to establish its sites of replication...
- Mechanism of dengue virus broad cross-neutralization by a monoclonal antibodyJoseph J B Cockburn
Unité de Virologie Structurale, Departement de Virologie, Institut Pasteur, 75724 Paris Cedex 15, France
Structure 20:303-14. 2012The dengue virus (DENV) complex is composed of four distinct but serologically related flaviviruses, which together cause the present-day most important emerging viral disease...
- High-content assay to identify inhibitors of dengue virus infectionDavid Shum
HTS Core Facility, Molecular Pharmacology and Chemistry Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
Assay Drug Dev Technol 8:553-70. 2010b>Dengue virus (DENV) infections are vectored by mosquitoes and constitute one of the most prevalent infectious diseases in many parts of the world, affecting millions of people annually...
- Dengue virus pathogenesis: an integrated viewByron E E Martina
Erasmus Medical Center, Department of Virology, Rotterdam, The Netherlands
Clin Microbiol Rev 22:564-81. 2009Much remains to be learned about the pathogenesis of the different manifestations of dengue virus (DENV) infections in humans...
- The pathogenesis of dengueJamie Whitehorn
Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Viet Nam
Vaccine 29:7221-8. 2011..This review summarises recent developments in the understanding of dengue pathogenesis and their relevance to dengue vaccine development...
- Spatial evaluation and modeling of Dengue seroprevalence and vector density in Rio de Janeiro, BrazilNildimar Alves Honorio
Laboratório de Transmissores de Hematozoários, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, Brasil
PLoS Negl Trop Dis 3:e545. 2009..We analyzed individual and spatial factors associated with seroprevalence using Generalized Additive Model (GAM)...
- Comparison of dengue virus type 2-specific small RNAs from RNA interference-competent and -incompetent mosquito cellsJaclyn C Scott
Arthropod Borne and Infectious Diseases Laboratory, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, USA
PLoS Negl Trop Dis 4:e848. 2010..Using deep sequencing technology, we characterized dengue virus type 2 (DENV2)-specific small RNAs produced during infection of Aedes aegypti mosquitoes and A...
- Monoclonal antibodies that bind to domain III of dengue virus E glycoprotein are the most efficient blockers of virus adsorption to Vero cellsW D Crill
Arbovirus Disease Branch, Division of Vector Borne Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U S Department of Health and Human Services, Fort Collins, Colorado 80522, USA
J Virol 75:7769-73. 2001..These results extend our understanding of the structure-function relationships in the E glycoprotein of DEN virus and provide the first direct evidence that domain III encodes the primary flavivirus receptor-binding motif...
- A protective role for dengue virus-specific CD8+ T cellsLauren E Yauch
Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
J Immunol 182:4865-73. 2009Infection with one of the four serotypes of dengue virus (DENV1-4) can result in a range of clinical manifestations in humans, from dengue fever to the more serious dengue hemorrhagic fever/dengue shock syndrome...
- Recent advances in deciphering viral and host determinants of dengue virus replication and pathogenesisKaren Clyde
Division of Infectious Diseases, School of Public Health, 140 Warren Hall, University of California, Berkeley, Berkeley, CA 94720 7360, USA
J Virol 80:11418-31. 2006
- Neurological manifestations of dengue infectionT Solomon
Wellcome Trust Clinical Research Unit, Cho Quan Hospital, Ho Chi Minh City, Vietnam
Lancet 355:1053-9. 2000..Severe forms of dengue, the most important arboviral infection of man, are associated with haemorrhagic disease and a generalised vascular leak syndrome. The importance of dengue as a cause of neurological disease is uncertain...
- Kinetics of plasma viremia and soluble nonstructural protein 1 concentrations in dengue: differential effects according to serotype and immune statusHuynh T L Duyen
Oxford University Clinical Research Unit, Churchill Hospital, Oxford, UK
J Infect Dis 203:1292-300. 2011..All children recovered fully, and only 5 required hospitalization. Among those with dengue virus type 1 (DENV-1), plasma viremia was significantly greater in primary (49) than secondary (44) infections and ..
- Dengue virus type 2: replication and tropisms in orally infected Aedes aegypti mosquitoesMa Isabel Salazar
Arthropod Borne and Infectious Diseases Laboratory, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado 80523 1692, USA
BMC Microbiol 7:9. 2007To be transmitted by its mosquito vector, dengue virus (DENV) must infect midgut epithelial cells, replicate and disseminate into the hemocoel, and finally infect the salivary glands, which is essential for transmission...
- Validation of an internally controlled one-step real-time multiplex RT-PCR assay for the detection and quantitation of dengue virus RNA in plasmaKien Duong Thi Hue
Oxford University Clinical Research Unit, Hospital for Tropical Diseases, 190 Ben Ham Tu, Quan 5, Ho Chi Minh City, Viet Nam
J Virol Methods 177:168-73. 2011..5 and 3 infectious particles per mL, is rapid and has been operationally characterized in 287 Vietnamese dengue patients from two therapeutic intervention trials at the Hospital for Tropical Diseases, Ho Chi Minh City, Viet Nam...
- High-resolution analysis of intrahost genetic diversity in dengue virus serotype 1 infection identifies mixed infectionsKhoa T D Thai
Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
J Virol 86:835-43. 2012Little is known about the rate at which genetic variation is generated within intrahost populations of dengue virus (DENV) and what implications this diversity has for dengue pathogenesis, disease severity, and host immunity...
- Dengue virus capsid protein usurps lipid droplets for viral particle formationMarcelo M Samsa
Fundación Instituto Leloir CONICET, Buenos Aires, Argentina
PLoS Pathog 5:e1000632. 2009b>Dengue virus is responsible for the highest rates of disease and mortality among the members of the Flavivirus genus. Dengue epidemics are still occurring around the world, indicating an urgent need of prophylactic vaccines and antivirals...
- Discovery of insect and human dengue virus host factorsOctober M Sessions
Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina 27710, USA
Nature 458:1047-50. 2009..This screen identified 116 candidate dengue virus host factors (DVHFs)...
- Dengue incidence in urban and rural Cambodia: results from population-based active fever surveillance, 2006-2008Sirenda Vong
Institut Pasteur Cambodia, Phnom Penh, Cambodia
PLoS Negl Trop Dis 4:e903. 2010..To estimate the true burden of dengue in the largest province of Cambodia, Kampong Cham, we conducted community-based active dengue fever surveillance among the 0-to-19-year age group in rural villages and urban areas during 2006-2008...
- Enzyme-linked immunosorbent assay specific to Dengue virus type 1 nonstructural protein NS1 reveals circulation of the antigen in the blood during the acute phase of disease in patients experiencing primary or secondary infectionsSophie Alcon
Unité des Arbovirus et Virus des Fièvres Hémorragiques, Institut Pasteur, 75724 Paris Cedex 15, France
J Clin Microbiol 40:376-81. 2002..vivo, we developed a sensitive enzyme-linked immunosorbent assay (ELISA) to detect the protein in the sera of dengue virus-infected patients...
- In-depth analysis of the antibody response of individuals exposed to primary dengue virus infectionRuklanthi de Alwis
Department of Microbiology and Immunology, and the Southeast Regional Center of Excellence for Biodefense and Emerging Infectious Diseases Research, University of North Carolina School of Medicine, Chapel Hill, NC, USA
PLoS Negl Trop Dis 5:e1188. 2011Humans who experience a primary dengue virus (DENV) infection develop antibodies that preferentially neutralize the homologous serotype responsible for infection...
- Inhibition of interferon signaling by dengue virusJorge L Munoz-Jordan
Department of Microbiology, Mount Sinai School of Medicine, One Gustave Levy Place, New York, NY 10029
Proc Natl Acad Sci U S A 100:14333-8. 2003b>Dengue virus is a worldwide-distributed mosquito-borne flavivirus with a positive strand RNA genome. Its transcribed polyprotein is cleaved by host- and virus-encoded peptidases into 10 proteins, some of which are of unknown function...
- Dengue virus neutralization by human immune sera: role of envelope protein domain III-reactive antibodyW M P B Wahala
Department of Microbiology and Immunology, CB 7290 University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
Virology 392:103-13. 2009..Our results have implications for understanding protective immunity following natural DENV infection and for evaluating DENV vaccines...
- Geographic expansion of dengue: the impact of international travelAnnelies Wilder-Smith
Department of Medicine, Travelers Screening and Vaccination Clinic, National University Hospital of Singapore, National University of Singapore, 5, Lower Kent Ridge, Singapore 119074
Med Clin North Am 92:1377-90, x. 2008..Epidemics of dengue, their seasonality, and oscillations over time are reflected by the epidemiology of dengue in travelers. Sentinel surveillance of travelers could augment existing national public health surveillance systems...
- Development of a recombinant tetravalent dengue virus vaccine: immunogenicity and efficacy studies in mice and monkeysDavid E Clements
Hawaii Biotech, Inc, 99 193 Aiea Heights Drive, Aiea, HI 96701, United States
Vaccine 28:2705-15. 2010Truncated recombinant dengue virus envelope protein subunits (80E) are efficiently expressed using the Drosophila Schneider-2 (S2) cell expression system...
- Enhanced infection of liver sinusoidal endothelial cells in a mouse model of antibody-induced severe dengue diseaseRaphaël M Zellweger
La Jolla Institute for Allergy and Immunology, CA 92037, USA
Cell Host Microbe 7:128-39. 2010b>Dengue virus (DENV) causes disease ranging from dengue fever (DF), a self-limited febrile illness, to the potentially lethal dengue hemorrhagic fever and dengue shock syndrome (DHF/DSS)...
- Autophagic machinery activated by dengue virus enhances virus replicationYing Ray Lee
Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan
Virology 374:240-8. 2008..We unravel that Dengue virus-2 (DV2) can trigger autophagic process in various infected cell lines demonstrated by GFP-LC3 dot formation and ..
- Progress towards a dengue vaccineDaniel P Webster
Department of Infectious Diseases and Microbiology, John Radcliffe Hospital, Oxford, UK
Lancet Infect Dis 9:678-87. 2009The spread of dengue virus throughout the tropics represents a major, rapidly growing public health problem with an estimated 2.5 billion people at risk of dengue fever and the life-threatening disease, severe dengue...
- Clinical and virological features of Dengue in Vietnamese infantsTran Nguyen Bich Chau
Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
PLoS Negl Trop Dis 4:e657. 2010..The clinical and laboratory features in infants with dengue have not been extensively characterised...
- The development of therapeutic antibodies that neutralize homologous and heterologous genotypes of dengue virus type 1Bimmi Shrestha
Department of Medicine, Washington University School of Medicine, St Louis, Missouri, United States of America
PLoS Pathog 6:e1000823. 2010..Overall, our experiments define a complex structural epitope on DIII of DENV-1 that can be recognized by protective antibodies with therapeutic potential...
- Clinical, epidemiologic, and virologic features of dengue in the 1998 epidemic in NicaraguaE Harris
Division of Infectious Diseases, School of Public Health, University of California, Berkeley 94720 7360, USA
Am J Trop Med Hyg 63:5-11. 2000..As evidenced by the analysis of this epidemic, the epidemiology of dengue can differ according to geographic region and viral serotype...
- Structure and function analysis of therapeutic monoclonal antibodies against dengue virus type 2Soila Sukupolvi-Petty
Department of Medicine, Washington University School of Medicine, 660 South Euclid Ave, Box 8051, St Louis, MO 63110, USA
J Virol 84:9227-39. 2010b>Dengue virus (DENV) is the most prevalent insect-transmitted viral disease in humans globally, and currently no specific therapy or vaccine is available...
- Serotype-specific differences in clinical manifestations of dengueAngel Balmaseda
Departamento de Virologia, Centro Nacional de Diagnostico y Referencia, Ministerio de Salud, Managua, Nicaragua
Am J Trop Med Hyg 74:449-56. 2006Dengue, the most prevalent arthropod-borne viral disease of humans, is caused by four serotypes of dengue virus (DENV 1-4)...
- Emerging flaviviruses: the spread and resurgence of Japanese encephalitis, West Nile and dengue virusesJohn S Mackenzie
Australian Biosecurity Cooperative Research Centre, Curtin University of Technology, Perth, Western Australia
Nat Med 10:S98-109. 2004....
- Emergence of the Asian 1 genotype of dengue virus serotype 2 in viet nam: in vivo fitness advantage and lineage replacement in South-East AsiaThi Ty Hang Vu
Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Viet Nam
PLoS Negl Trop Dis 4:e757. 2010A better description of the extent and structure of genetic diversity in dengue virus (DENV) in endemic settings is central to its eventual control...
- Heat shock protein 90 and heat shock protein 70 are components of dengue virus receptor complex in human cellsJorge Reyes-Del Valle
Departamento de Patologia Experimental, Centro de Investigacion y de Estudios Avanzados del IPN, Av I P N 2508, Col San Pedro Zacatenco, Mexico City D F, C P 07360, Mexico
J Virol 79:4557-67. 2005b>Dengue virus requires the presence of an unidentified cellular receptor on the surface of the host cell...
- Spatial and temporal clustering of dengue virus transmission in Thai villagesMammen P Mammen
Department of Virology, Armed Forces Research Institute of Medical Sciences AFRIMS, Bangkok, Thailand
PLoS Med 5:e205. 2008..To test the hypothesis that DENV transmission is spatially and temporally focal, we compared geographic and temporal characteristics within Thai villages where DENV are and are not being actively transmitted...
- The mannose receptor mediates dengue virus infection of macrophagesJoanna L Miller
Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom
PLoS Pathog 4:e17. 2008Macrophages (MØ) and mononuclear phagocytes are major targets of infection by dengue virus (DV), a mosquito-borne flavivirus that can cause haemorrhagic fever in humans...
- Flavivirus activates phosphatidylinositol 3-kinase signaling to block caspase-dependent apoptotic cell death at the early stage of virus infectionChyan Jang Lee
Graduate Institute of Life Sciences, Taipei, Taiwan, Republic of China
J Virol 79:8388-99. 2005Flaviviruses such as dengue virus (DEN) and Japanese encephalitis virus (JEV) are medically important in humans...
- Seroprevalence and risk factors for dengue infection in socio-economically distinct areas of Recife, BrazilCynthia Braga
Centro de Pesquisas Aggeu Magalhaes, Fundacao Oswaldo Cruz, Av Professor Moraes Rego, S N, Cidade Universitaria, CEP 50670 420, Recife, PE, Brazil
Acta Trop 113:234-40. 2010..In the deprived area, 59% of children had already been exposed to dengue virus by the age of 5 years and the estimated force of infection was three times higher than that in the privileged ..
- A mouse-passaged dengue virus strain with reduced affinity for heparan sulfate causes severe disease in mice by establishing increased systemic viral loadsTyler R Prestwood
Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, California 92037, USA
J Virol 82:8411-21. 2008The four serotypes of dengue virus (DENV1 to DENV4) cause extensive morbidity and mortality. A major obstacle to studying disease pathogenesis and developing therapies has been the lack of a small-animal model...
- NS5 of dengue virus mediates STAT2 binding and degradationJoseph Ashour
Department of Microbiology, Emerging Pathogens Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
J Virol 83:5408-18. 2009..b>Dengue virus (DENV) encodes several proteins (NS2a, NS4a, and NS4b) that have been shown individually to inhibit the IFN ..
- Serotype-specific dengue virus circulation and dengue disease in Bangkok, Thailand from 1973 to 1999Ananda Nisalak
Department of Virology, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand
Am J Trop Med Hyg 68:191-202. 2003b>Dengue virus circulation and association with epidemics and severe dengue disease were studied in hospitalized children with suspected dengue at the Queen Sirikit National Institute of Child Health in Bangkok, Thailand, from 1973 to 1999...
- Identification of a recombinant dengue virus type 1 with 3 recombination regions in natural populations in Guangdong province, ChinaS P Chen
State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, No 20 Dongdajie Street, Fengtai District, Beijing 100071, China
Arch Virol 153:1175-9. 2008Using recombination analysis, we identified a recombinant dengue virus type 1 strain, namely, GD23/95, with three recombination regions, located within the sequences of the prM/E junction, NS1, and NS3, respectively...
- Serotype-specific differences in the risk of dengue hemorrhagic fever: an analysis of data collected in Bangkok, Thailand from 1994 to 2006Jessica R Fried
Mahidol Oxford Tropical Medicine Research Unit MORU, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
PLoS Negl Trop Dis 4:e617. 2010..It is unclear whether dengue serotypes differ in their propensity to cause severe disease. We analyzed differences in serotype-specific disease severity in children presenting for medical attention in Bangkok, Thailand...
- Structural and functional studies of the promoter element for dengue virus RNA replicationMaria F Lodeiro
Fundacion Instituto Leloir, Buenos Aires, Argentina
J Virol 83:993-1008. 2009The 5' untranslated region (5'UTR) of the dengue virus (DENV) genome contains two defined elements essential for viral replication. At the 5' end, a large stem-loop (SLA) structure functions as the promoter for viral polymerase activity...
- Flavivirus induces interferon-beta gene expression through a pathway involving RIG-I-dependent IRF-3 and PI3K-dependent NF-kappaB activationTsung Hsien Chang
Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan, ROC
Microbes Infect 8:157-71. 2006In this study, we found that infection with flaviviruses, such as Japanese encephalitis virus (JEV) and dengue virus serotype 2 (DEN-2), leads to interferon-beta (IFN-beta) gene expression in a virus-replication- and de novo protein-..
- Serotype-specific detection of dengue viruses in a fourplex real-time reverse transcriptase PCR assayBarbara W Johnson
Diagnostic and Reference Laboratory, Arbovirus Diseases Branch, Division of Vector Borne Infectious Diseases, Centers for Disease Control and Prevention, 3150 Rampart Rd, Fort, Collins, CO 80521
J Clin Microbiol 43:4977-83. 2005....
- Dendritic cell-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN)-mediated enhancement of dengue virus infection is independent of DC-SIGN internalization signalsPierre Yves Lozach
Unite d Immunologie Virale, Institut Pasteur Paris, 25 28, rue du Dr Roux, 75724 Paris Cedex 15, France
J Biol Chem 280:23698-708. 2005b>Dengue virus (DV) is a mosquito-borne flavivirus that causes hemorrhagic fever in humans...
- Stable introduction of a life-shortening Wolbachia infection into the mosquito Aedes aegyptiConor J McMeniman
School of Integrative Biology, University of Queensland, Brisbane 4072, Australia
Science 323:141-4. 2009..Our data suggest that targeting mosquito age with inherited Wolbachia infections may be a viable strategy to reduce the transmission of pathogens such as dengue viruses...
- Identification of GRP 78 (BiP) as a liver cell expressed receptor element for dengue virus serotype 2S Jindadamrongwech
Molecular Pathology Laboratory, Institute of Molecular Biology and Genetics, Mahidol University, Nakorn Pathom, Thailand
Arch Virol 149:915-27. 2004This study sought to identify receptor elements for dengue virus serotype 2 on human liver cells (HepG2) using the viral overlay protein binding assay (VOPBA) technique and Mass Spectrometry fingerprinting...
- An antigen capture enzyme-linked immunosorbent assay reveals high levels of the dengue virus protein NS1 in the sera of infected patientsP R Young
Sir Albert Sakzewski Virus Research Centre, The Royal Children s Hospital, Herston, Brisbane 4029, Australia
J Clin Microbiol 38:1053-7. 2000We describe the development of a capture enzyme-linked immunosorbent assay for the detection of the dengue virus nonstructural protein NS1...
- Pathogenesis of flavivirus infections: using and abusing the host cellMaria Dolores Fernandez-Garcia
Unité Pathogénie Virale, INSERM U819, Institut Pasteur, Departement de Virologie, Paris, France
Cell Host Microbe 5:318-28. 2009Flaviviruses, such as the dengue virus and the West Nile virus, are emerging arthropod-borne viruses that represent an immense global health problem...
- Translation elongation factor-1alpha, La, and PTB interact with the 3' untranslated region of dengue 4 virus RNAMonica De Nova-Ocampo
Departamento de Biomedicina Molecular, Centro de Investigacion y de Estudios Avanzados del IPN, Mexico City 07360, Mexico
Virology 295:337-47. 2002..The latter are duplicated (CS2A and CS2B) in DEN4. Dengue virus replication, like that of other RNA viruses, might involve the cis-elements located within the 3'UTR and the ..
- Evaluation of two new commercial tests for the diagnosis of acute dengue virus infection using NS1 antigen detection in human serumPhilippe Dussart
Centre National de Référence des Arbovirus et Virus Influenza, Région Antilles Guyane, Institut Pasteur de la Guyane, Cayenne, French Guiana
PLoS Negl Trop Dis 2:e280. 2008..performance of two new commercial tests for the detection of dengue NS1 protein during the clinical phase of dengue virus (DENV) infection-an immunochromatographic test allowing rapid detection of the NS1 antigen, Dengue NS1 Ag STRIP ..
- Human TLR3 recognizes dengue virus and modulates viral replication in vitroYi Ting Tsai
Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan
Cell Microbiol 11:604-15. 2009..This study aims at the interaction between dengue virus (DENV) and human TLRs at the incipient stage of infection in vitro...
- Inferring the rate and time-scale of dengue virus evolutionS Susanna Twiddy
Department of Zoology, University of Oxford, Oxford, United Kingdom
Mol Biol Evol 20:122-9. 2003..To understand the rate at which genetic diversification occurs in dengue virus and to infer the time-scale of its evolution, we employed a maximum likelihood method that uses information ..
- Molecular evolution of dengue viruses: contributions of phylogenetics to understanding the history and epidemiology of the preeminent arboviral diseaseScott C Weaver
Department of Pathology, Center for Tropical Diseases, University of Texas Medical Branch, Galveston, TX 77555 0609, USA
Infect Genet Evol 9:523-40. 2009....
- Humanized mice show clinical signs of dengue fever according to infecting virus genotypeJavier Mota
Department of Virology and Immunology, Southwest Foundation for Biomedical Research, San Antonio, TX 78227, USA
J Virol 83:8638-45. 2009..of humanized NOD-scid IL2r gamma(null) mice with different strains (representing the four genotypes) of dengue virus serotype 2 (DEN-2) can induce the development of human-like disease, including fever, viremia, erythema, and ..
- Cytokine cascade in dengue hemorrhagic fever: implications for pathogenesisU C Chaturvedi
Department of Microbiology, Faculty of Medicine, Kuwait University, Safat, Kuwait
FEMS Immunol Med Microbiol 28:183-8. 2000b>Dengue virus produces a mild acute febrile illness, dengue fever (DF) and a severe illness, dengue hemorrhagic fever (DHF)...
- Dengue-virus-infected dendritic cells trigger vascular leakage through metalloproteinase overproductionNatthanej Luplertlop
Institut de Recherche pour le Developpement, IRD, Immunologie Virale et Moléculaire, UR178 IFR122, 34094 Montpellier, France
EMBO Rep 7:1176-81. 2006b>Dengue virus (DV) is an important re-emerging arthropod-borne virus of global significance...
- Small RNA profiling of Dengue virus-mosquito interactions implicates the PIWI RNA pathway in anti-viral defenseAnn M Hess
Department of Statistics, Colorado State University, Fort Collins, Colorado 80523, USA
BMC Microbiol 11:45. 2011..aegypti, we deep-sequenced small non-coding RNAs. Triplicate biological replicates were used so that rigorous statistical metrics could be applied...
- Dengue Epitope Vaccine,Tetravalent & MHCII-TargetedJ Thomas August; Fiscal Year: 2007..The vaccine constructs will be validated for human dengue virus specific T- and B-cell responses by the human ex vivo assay system (Project 2), and by mouse immunization for ..
- Inhibition of the Membrane Fusion Proteins of Flaviviruses and AlphavirusesMargaret Kielian; Fiscal Year: 2007..b>Dengue virus (DV) is currently of particular concern as it has dramatically reemerged to become endemic in more than 100 ..
- Host factors involved in viral RNA recombinationPeter Nagy; Fiscal Year: 2006..has been demonstrated to occur for a large number of human, animal and plant viruses, including poliovirus, dengue virus, infectious bronchitis virus, influenza A virus, hantavirus, hepatitis D virus, Human Respiratory Syncytial ..
- A HTS Assay for Identifying Anti-Viral Drugs Against Arbovirus InfectionsQianjun Li; Fiscal Year: 2007..Several recent human and/or animal epidemics are caused by arboviruses, including Dengue virus (DNV) in Asia, West Nile virus (WNV) in North America and Bluetongue virus (BTV) in Europe...
- Yellow Fever/Dengue Virus Competence in Aedes aegypt aegypti/formosus in SenegalWilliam Black; Fiscal Year: 2009..l.) is the primary vector to humans of yellow fever virus (YFV) and the four serotypes of dengue virus (DENV1-4)...
- Yellow Fever/Dengue Virus Competence in Aedes aegypt aegypti/formosus in SenegalWilliam C Black; Fiscal Year: 2010..l.) is the primary vector to humans of yellow fever virus (YFV) and the four serotypes of dengue virus (DENV1-4)...
- Antiviral potential of helicase inhibitorsDavid N Frick; Fiscal Year: 2010..RNA viruses, focusing on pathogens with abnormally high global burdens of disease: hepatitis C virus (HCV), Dengue virus (DENV), West Nile virus (WNV), Japanese encephalitis virus (JEV), yellow fever virus (YFV), and human ..
- Role of an essential RNA chaperone in virus replicationPeter Nagy; Fiscal Year: 2006..numerous other important human and animal viruses (hepatitis C virus, flavivirus, including West Nile virus and dengue virus, pestiviruses) and plant viruses (luteo- and carmoviruses), understanding the mechanism of RNA replication in ..
- MOLECULAR BIOLOGY OF POLIOVIRUS RNA REPLICATIONJAMES FLANEGAN; Fiscal Year: 2009..RNA viruses that form a large group of important human pathogens include hepatitis C virus, West Nile virus, dengue virus and the SARS-associated coronavirus...
- FUNCTIONAL ANALYSIS OF DENGUE VIRUS ANTIGENS NS3 AND NS5Radhakrishnan Padmanabhan; Fiscal Year: 1993..Dengue is a human disease caused by the mosquito-borne dengue virus.Apart from dengue fever, a more severe and fatal form of the disease occurs in children called dengue ..
- MOLECULAR BIOLOGY OF POLIOVIRUS RNA REPLICATIONJames Bert Flanegan; Fiscal Year: 2010..RNA viruses that form a large group of important human pathogens include hepatitis C virus, West Nile virus, dengue virus and the SARS-associated coronavirus...
- MOLECULAR BIOLOGY OF POLIOVIRUS RNA REPLICATIONJAMES FLANEGAN; Fiscal Year: 2007..RNA viruses that form a large group of important human pathogens include hepatitis C virus, West Nile virus, dengue virus and the SARS-associated coronavirus...
- MOLECULAR BIOLOGY OF POLIOVIRUS RNA REPLICATIONJAMES FLANEGAN; Fiscal Year: 2006
- Determinants of RNA virus evolutionISABEL NOVELLA; Fiscal Year: 2007..and C viruses, HIV, influenza virus, most of the cold viruses, rabies virus, Ebola virus, West Nile virus, and dengue virus. We face major difficulties in controlling these viral diseases because of the viruses' escape from immune ..
- Determinants of RNA virus evolutionISABEL NOVELLA; Fiscal Year: 2009..and C viruses, HIV, influenza virus, most of the cold viruses, rabies virus, Ebola virus, West Nile virus, and dengue virus. We face major difficulties in controlling these viral diseases because of the viruses' escape from immune ..
- Recombinant antigen assays for Lassa and other arenaviruRobert Garry; Fiscal Year: 2005..a deliberate release, and allow the virus used to be distinguished from other hemorrhagic fever viruses such as dengue virus or Ebola virus that may have similar case presentations...
- Arbovirus quasispecies-impact of arthropod transmissionGREGORY EBEL; Fiscal Year: 2004..RNA viruses, such as West Nile virus, Dengue virus, Rift Valley fever virus and Venezuelan Equine Encephalitis virus, exist within each host as a genetically ..
- INTERFERENCE TO DENGUE VIRUS REPLICATION IN MOSQUITOESCarol Blair; Fiscal Year: 2001..In toto, this work should give us significant understanding of which anti-DEN virus strategies are important for ultimately generating transgenic mosquitoes that are resistant to DEN virus infections. ..
- MOLECULAR ANALYSIS OF ALPHAVIRUS MEMBRANE FUSION PROTEINMargaret Kielian; Fiscal Year: 2010..such as the encephalitic alphaviruses and the flaviviruses West Nile, yellow fever, Japanese encephalitis and dengue virus (DV)...
- MOLECULAR ANALYSIS OF ALPHAVIRUS MEMBRANE FUSION PROTEINMargaret Kielian; Fiscal Year: 2009..such as the encephalitic alphaviruses and the flaviviruses West Nile, yellow fever, Japanese encephalitis and dengue virus (DV)...
- A VEE Replicon-Based Vaccine for Dengue VirusLaura White; Fiscal Year: 2006b>Dengue virus (DEN), a priority "A" pathogen on the NIH/CDC list of bioterrorism related and emerging pathogens, infects humans causing a spectrum of clinical manifestations including dengue fever, dengue hemorrhagic fever and dengue shock ..
- Yeast-Based High-throughput Assays for Proteases of Category A, B, & C VirusesHong Fang; Fiscal Year: 2009..In the proposed studies, we will develop yeast assays for proteases produced by seven RNA viruses: Dengue Virus, West Nile Virus, Japanese Encephalitis Virus, Yellow Fever Virus, Hepatitis A Virus, SARS coronavirus, and ..
- Yeast-Based High-throughput Assays for Proteases of Category A, B, & C VirusesHong Fang; Fiscal Year: 2007..In the proposed studies, we will develop yeast assays for proteases produced by seven RNA viruses: Dengue Virus, West Nile Virus, Japanese Encephalitis Virus, Yellow Fever Virus, Hepatitis A Virus, SARS coronavirus, and ..
- Lethal Mutagenesis as an Antiviral StrategyCraig Cameron; Fiscal Year: 2007..Establish dengue virus type 2 as a model system for evaluation of lethal mutagenesis by characterizing the mechanism of action of ..
- Broad-Spectrum Therapeutic Human Antibodies for Dengue Virus InfectionsYorgo Modis; Fiscal Year: 2006..epitopes can prevent and treat infection by several different flaviviruses, including all 4 serotypes of dengue virus and West Nile virus (WNV). Passive immunization is an accepted medical practice to protect against infection...
- FUNCTIONAL ANALYSIS OF DENGUE VIRUS ANTIGENS NS3 AND NS5Radhakrishnan Padmanabhan; Fiscal Year: 2003..To study the mechanism of replication in the absence of virion assembly, a subgenomic dengue virus replicon expressing a readily quantifiable reporter gene product will be constructed. 3...
- Structure and Function of FlavivirusesMICHAEL ROSSMANN; Fiscal Year: 2009..This structure has made it possible to build pseudo-atomic models of immature dengue virus and of a low pH intermediate prior to the release of the pr polypeptide and maturation into infectious ..
- Apoptosis as an anti-viral response in mosquito midgutROLLIE CLEM; Fiscal Year: 2007..are important vectors for a number of infectious diseases caused by arboviruses including West Nile virus, dengue virus, yellow fever virus, LaCrosse virus, and Venezuelan, eastern and western equine encephalitis viruses...
- Structure and Function of FlavivirusesMichael G Rossmann; Fiscal Year: 2010..This structure has made it possible to build pseudo-atomic models of immature dengue virus and of a low pH intermediate prior to the release of the pr polypeptide and maturation into infectious ..