dengue virus

Summary

Summary: A species of the genus FLAVIVIRUS which causes an acute febrile and sometimes hemorrhagic disease in man. Dengue is mosquito-borne and four serotypes are known.

Top Publications

  1. ncbi Dengue
    Scott B Halstead
    Supportive Research and Development, Pediatric Dengue Vaccine Initiative, Internal Vaccine Institute, Seoul, South Korea
    Lancet 370:1644-52. 2007
  2. ncbi Cross-reacting antibodies enhance dengue virus infection in humans
    Wanwisa Dejnirattisai
    Department of Medicine, Imperial College London, London W12 0NN, UK
    Science 328:745-8. 2010
  3. ncbi Global spread and persistence of dengue
    Jennifer L Kyle
    Division of Infectious Diseases, School of Public Health, and Graduate Group in Microbiology, University of California, Berkeley, California 94720 7354, USA
    Annu Rev Microbiol 62:71-92. 2008
  4. ncbi RNA interference screen for human genes associated with West Nile virus infection
    Manoj N Krishnan
    Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticutt 06520 8031, USA
    Nature 455:242-5. 2008
  5. ncbi The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus
    Abraham L Brass
    Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard Medical School, Charlestown, MA 02129, USA
    Cell 139:1243-54. 2009
  6. ncbi The Aedes aegypti toll pathway controls dengue virus infection
    Zhiyong Xi
    W Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States of America
    PLoS Pathog 4:e1000098. 2008
  7. ncbi Prospects for a dengue virus vaccine
    Stephen S Whitehead
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Rev Microbiol 5:518-28. 2007
  8. ncbi Discovery of insect and human dengue virus host factors
    October M Sessions
    Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nature 458:1047-50. 2009
  9. ncbi The endosymbiotic bacterium Wolbachia induces resistance to dengue virus in Aedes aegypti
    Guowu Bian
    Department of Entomology and Genetics Program, Michigan State University, East Lansing, Michigan, United States of America
    PLoS Pathog 6:e1000833. 2010
  10. ncbi Composition and three-dimensional architecture of the dengue virus replication and assembly sites
    Sonja Welsch
    Department of Molecular Virology, University of Heidelberg, Im Neuenheimer Feld 345, Heidelberg D 69120, Germany
    Cell Host Microbe 5:365-75. 2009

Research Grants

  1. Dengue Epitope Vaccine,Tetravalent & MHCII-Targeted
    J Thomas August; Fiscal Year: 2007
  2. Host factors involved in viral RNA recombination
    Peter Nagy; Fiscal Year: 2006
  3. Inhibition of the Membrane Fusion Proteins of Flaviviruses and Alphaviruses
    Margaret Kielian; Fiscal Year: 2007
  4. A HTS Assay for Identifying Anti-Viral Drugs Against Arbovirus Infections
    Qianjun Li; Fiscal Year: 2007
  5. Yellow Fever/Dengue Virus Competence in Aedes aegypt aegypti/formosus in Senegal
    William Black; Fiscal Year: 2009
  6. Yellow Fever/Dengue Virus Competence in Aedes aegypt aegypti/formosus in Senegal
    William C Black; Fiscal Year: 2010
  7. Antiviral potential of helicase inhibitors
    David N Frick; Fiscal Year: 2010
  8. Role of an essential RNA chaperone in virus replication
    Peter Nagy; Fiscal Year: 2006
  9. MOLECULAR BIOLOGY OF POLIOVIRUS RNA REPLICATION
    JAMES FLANEGAN; Fiscal Year: 2007
  10. MOLECULAR BIOLOGY OF POLIOVIRUS RNA REPLICATION
    James Bert Flanegan; Fiscal Year: 2010

Detail Information

Publications274 found, 100 shown here

  1. ncbi Dengue
    Scott B Halstead
    Supportive Research and Development, Pediatric Dengue Vaccine Initiative, Internal Vaccine Institute, Seoul, South Korea
    Lancet 370:1644-52. 2007
    ..Here, I review and discuss data on clinical diagnosis and pathophysiology of vascular permeability and coagulopathy, parenteral treatment of DHF/DSS, and new laboratory tests...
  2. ncbi Cross-reacting antibodies enhance dengue virus infection in humans
    Wanwisa Dejnirattisai
    Department of Medicine, Imperial College London, London W12 0NN, UK
    Science 328:745-8. 2010
    b>Dengue virus co-circulates as four serotypes, and sequential infections with more than one serotype are common...
  3. ncbi Global spread and persistence of dengue
    Jennifer L Kyle
    Division of Infectious Diseases, School of Public Health, and Graduate Group in Microbiology, University of California, Berkeley, California 94720 7354, USA
    Annu Rev Microbiol 62:71-92. 2008
    ..urbanization in tropical and subtropical countries, breeding sites for the mosquitoes that transmit dengue virus have proliferated, and successful vector control has proven problematic...
  4. ncbi RNA interference screen for human genes associated with West Nile virus infection
    Manoj N Krishnan
    Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticutt 06520 8031, USA
    Nature 455:242-5. 2008
    ..By extending this study to dengue virus, we show that flaviviruses have both overlapping and unique interaction strategies with host cells...
  5. ncbi The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus
    Abraham L Brass
    Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard Medical School, Charlestown, MA 02129, USA
    Cell 139:1243-54. 2009
    ..characterization revealed that the IFITM proteins inhibit the early replication of flaviviruses, including dengue virus and West Nile virus...
  6. ncbi The Aedes aegypti toll pathway controls dengue virus infection
    Zhiyong Xi
    W Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States of America
    PLoS Pathog 4:e1000098. 2008
    ..gene expression and RNA interference (RNAi)-based reverse genetic analyses, to characterize its response to dengue virus infection in different body compartments...
  7. ncbi Prospects for a dengue virus vaccine
    Stephen S Whitehead
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Rev Microbiol 5:518-28. 2007
    ..A tetravalent vaccine is urgently needed and must be effective against all four dengue virus serotypes, be cost-effective and provide long-term protection...
  8. ncbi Discovery of insect and human dengue virus host factors
    October M Sessions
    Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nature 458:1047-50. 2009
    ..This screen identified 116 candidate dengue virus host factors (DVHFs)...
  9. ncbi The endosymbiotic bacterium Wolbachia induces resistance to dengue virus in Aedes aegypti
    Guowu Bian
    Department of Entomology and Genetics Program, Michigan State University, East Lansing, Michigan, United States of America
    PLoS Pathog 6:e1000833. 2010
    ..Given the large overlap in tissue distribution and intracellular localization between Wolbachia and dengue virus in mosquitoes, we conducted experiments to characterize their interactions...
  10. ncbi Composition and three-dimensional architecture of the dengue virus replication and assembly sites
    Sonja Welsch
    Department of Molecular Virology, University of Heidelberg, Im Neuenheimer Feld 345, Heidelberg D 69120, Germany
    Cell Host Microbe 5:365-75. 2009
    ..Using electron microscopy, we find Dengue virus (DENV)-induced vesicles, convoluted membranes, and virus particles to be endoplasmic reticulum (ER)-derived, ..
  11. ncbi Autophagic machinery activated by dengue virus enhances virus replication
    Ying Ray Lee
    Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    Virology 374:240-8. 2008
    ..We unravel that Dengue virus-2 (DV2) can trigger autophagic process in various infected cell lines demonstrated by GFP-LC3 dot formation and ..
  12. ncbi An evolutionary conserved function of the JAK-STAT pathway in anti-dengue defense
    Jayme A Souza-Neto
    W Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, The Johns Hopkins University, 615 North Wolfe Street E4209, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 106:17841-6. 2009
    Here, we show that the major mosquito vector for dengue virus uses the JAK-STAT pathway to control virus infection. Dengue virus infection in Aedes aegypti mosquitoes activates the JAK-STAT immune signaling pathway...
  13. ncbi Progress towards a dengue vaccine
    Daniel P Webster
    Department of Infectious Diseases and Microbiology, John Radcliffe Hospital, Oxford, UK
    Lancet Infect Dis 9:678-87. 2009
    The spread of dengue virus throughout the tropics represents a major, rapidly growing public health problem with an estimated 2.5 billion people at risk of dengue fever and the life-threatening disease, severe dengue...
  14. ncbi The development of therapeutic antibodies that neutralize homologous and heterologous genotypes of dengue virus type 1
    Bimmi Shrestha
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS Pathog 6:e1000823. 2010
    ..Overall, our experiments define a complex structural epitope on DIII of DENV-1 that can be recognized by protective antibodies with therapeutic potential...
  15. ncbi Clinical and virological features of Dengue in Vietnamese infants
    Tran Nguyen Bich Chau
    Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
    PLoS Negl Trop Dis 4:e657. 2010
    ..The clinical and laboratory features in infants with dengue have not been extensively characterised...
  16. ncbi Development of a recombinant tetravalent dengue virus vaccine: immunogenicity and efficacy studies in mice and monkeys
    David E Clements
    Hawaii Biotech, Inc, 99 193 Aiea Heights Drive, Aiea, HI 96701, United States
    Vaccine 28:2705-15. 2010
    Truncated recombinant dengue virus envelope protein subunits (80E) are efficiently expressed using the Drosophila Schneider-2 (S2) cell expression system...
  17. ncbi Dengue virus type 2: replication and tropisms in orally infected Aedes aegypti mosquitoes
    Ma Isabel Salazar
    Arthropod Borne and Infectious Diseases Laboratory, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado 80523 1692, USA
    BMC Microbiol 7:9. 2007
    To be transmitted by its mosquito vector, dengue virus (DENV) must infect midgut epithelial cells, replicate and disseminate into the hemocoel, and finally infect the salivary glands, which is essential for transmission...
  18. ncbi Enhanced infection of liver sinusoidal endothelial cells in a mouse model of antibody-induced severe dengue disease
    Raphaël M Zellweger
    La Jolla Institute for Allergy and Immunology, CA 92037, USA
    Cell Host Microbe 7:128-39. 2010
    b>Dengue virus (DENV) causes disease ranging from dengue fever (DF), a self-limited febrile illness, to the potentially lethal dengue hemorrhagic fever and dengue shock syndrome (DHF/DSS)...
  19. ncbi Dengue viremia titer, antibody response pattern, and virus serotype correlate with disease severity
    D W Vaughn
    Department of Virus Diseases, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA
    J Infect Dis 181:2-9. 2000
    Viremia titers in serial plasma samples from 168 children with acute dengue virus infection who were enrolled in a prospective study at 2 hospitals in Thailand were examined to determine the role of virus load in the pathogenesis of ..
  20. ncbi Inhibition of interferon signaling by dengue virus
    Jorge L Munoz-Jordan
    Department of Microbiology, Mount Sinai School of Medicine, One Gustave Levy Place, New York, NY 10029
    Proc Natl Acad Sci U S A 100:14333-8. 2003
    b>Dengue virus is a worldwide-distributed mosquito-borne flavivirus with a positive strand RNA genome. Its transcribed polyprotein is cleaved by host- and virus-encoded peptidases into 10 proteins, some of which are of unknown function...
  21. ncbi Dengue: a continuing global threat
    Maria G Guzman
    Instituto de Medicina Tropical, Pedro Kouri, PO Box 601, Marianao 13, Ciucad de la Habana, Cuba
    Nat Rev Microbiol 8:S7-16. 2010
    ..Illness is produced by any of the four dengue virus serotypes...
  22. ncbi Structure of dengue virus: implications for flavivirus organization, maturation, and fusion
    Richard J Kuhn
    Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA
    Cell 108:717-25. 2002
    ..The structure suggests that flaviviruses, and by analogy also alphaviruses, employ a fusion mechanism in which the distal beta barrels of domain II of the glycoprotein E are inserted into the cellular membrane...
  23. ncbi Clinical, epidemiologic, and virologic features of dengue in the 1998 epidemic in Nicaragua
    E Harris
    Division of Infectious Diseases, School of Public Health, University of California, Berkeley 94720 7360, USA
    Am J Trop Med Hyg 63:5-11. 2000
    ..As evidenced by the analysis of this epidemic, the epidemiology of dengue can differ according to geographic region and viral serotype...
  24. ncbi Structure and function analysis of therapeutic monoclonal antibodies against dengue virus type 2
    Soila Sukupolvi-Petty
    Department of Medicine, Washington University School of Medicine, 660 South Euclid Ave, Box 8051, St Louis, MO 63110, USA
    J Virol 84:9227-39. 2010
    b>Dengue virus (DENV) is the most prevalent insect-transmitted viral disease in humans globally, and currently no specific therapy or vaccine is available...
  25. ncbi The human immune response to Dengue virus is dominated by highly cross-reactive antibodies endowed with neutralizing and enhancing activity
    Martina Beltramello
    Institute for Research in Biomedicine, Bellinzona 6500, Switzerland
    Cell Host Microbe 8:271-83. 2010
    Antibodies protect against homologous Dengue virus (DENV) infection but can precipitate severe dengue by promoting heterotypic virus entry via Fcγ receptors (FcγR)...
  26. ncbi Consequences of the expanding global distribution of Aedes albopictus for dengue virus transmission
    Louis Lambrechts
    Department of Virology, Institut Pasteur, Paris, France
    PLoS Negl Trop Dis 4:e646. 2010
    ..of numerous arthropod-borne viruses (arboviruses), including the most prevalent arboviral pathogen of humans, dengue virus (DENV). Ae...
  27. ncbi Serotype-specific differences in clinical manifestations of dengue
    Angel Balmaseda
    , , Ministerio de Salud, Managua, Nicaragua
    Am J Trop Med Hyg 74:449-56. 2006
    Dengue, the most prevalent arthropod-borne viral disease of humans, is caused by four serotypes of dengue virus (DENV 1-4)...
  28. ncbi Emergence of the Asian 1 genotype of dengue virus serotype 2 in viet nam: in vivo fitness advantage and lineage replacement in South-East Asia
    Thi Ty Hang Vu
    Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Viet Nam
    PLoS Negl Trop Dis 4:e757. 2010
    A better description of the extent and structure of genetic diversity in dengue virus (DENV) in endemic settings is central to its eventual control...
  29. ncbi Emerging flaviviruses: the spread and resurgence of Japanese encephalitis, West Nile and dengue viruses
    John S Mackenzie
    Australian Biosecurity Cooperative Research Centre, Curtin University of Technology, Perth, Western Australia
    Nat Med 10:S98-109. 2004
    ....
  30. ncbi The mannose receptor mediates dengue virus infection of macrophages
    Joanna L Miller
    Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom
    PLoS Pathog 4:e17. 2008
    Macrophages (MØ) and mononuclear phagocytes are major targets of infection by dengue virus (DV), a mosquito-borne flavivirus that can cause haemorrhagic fever in humans...
  31. ncbi Spatial and temporal clustering of dengue virus transmission in Thai villages
    Mammen P Mammen
    Department of Virology, Armed Forces Research Institute of Medical Sciences AFRIMS, Bangkok, Thailand
    PLoS Med 5:e205. 2008
    ..To test the hypothesis that DENV transmission is spatially and temporally focal, we compared geographic and temporal characteristics within Thai villages where DENV are and are not being actively transmitted...
  32. ncbi Heat shock protein 90 and heat shock protein 70 are components of dengue virus receptor complex in human cells
    Jorge Reyes-Del Valle
    Departamento de Patologia Experimental, Centro de Investigacion y de Estudios Avanzados del IPN, Av I P N 2508, Col San Pedro Zacatenco, Mexico City D F, C P 07360, Mexico
    J Virol 79:4557-67. 2005
    b>Dengue virus requires the presence of an unidentified cellular receptor on the surface of the host cell...
  33. ncbi Flavivirus activates phosphatidylinositol 3-kinase signaling to block caspase-dependent apoptotic cell death at the early stage of virus infection
    Chyan Jang Lee
    Graduate Institute of Life Sciences, Taipei, Taiwan, Republic of China
    J Virol 79:8388-99. 2005
    Flaviviruses such as dengue virus (DEN) and Japanese encephalitis virus (JEV) are medically important in humans...
  34. ncbi Identification of five interferon-induced cellular proteins that inhibit west nile virus and dengue virus infections
    Dong Jiang
    Drexel Institute for Biotechnology and Virology Research, Department of Microbiology and Immunology, Drexel University College of Medicine, Doylestown, Pennsylvania 18902, USA
    J Virol 84:8332-41. 2010
    ..that instigate an antiviral state against two medically important flaviviruses, West Nile virus (WNV) and dengue virus (DENV), we tested 36 ISGs that are commonly induced by IFN-alpha for antiviral activity against the two viruses...
  35. ncbi Serotype-specific dengue virus circulation and dengue disease in Bangkok, Thailand from 1973 to 1999
    Ananda Nisalak
    Department of Virology, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand
    Am J Trop Med Hyg 68:191-202. 2003
    b>Dengue virus circulation and association with epidemics and severe dengue disease were studied in hospitalized children with suspected dengue at the Queen Sirikit National Institute of Child Health in Bangkok, Thailand, from 1973 to 1999...
  36. ncbi Comparison of dengue virus type 2-specific small RNAs from RNA interference-competent and -incompetent mosquito cells
    Jaclyn C Scott
    Arthropod Borne and Infectious Diseases Laboratory, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, USA
    PLoS Negl Trop Dis 4:e848. 2010
    ..Using deep sequencing technology, we characterized dengue virus type 2 (DENV2)-specific small RNAs produced during infection of Aedes aegypti mosquitoes and A...
  37. ncbi Dengue and dengue hemorrhagic fever
    D J Gubler
    Division of Vector Borne Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado 80522, USA
    Clin Microbiol Rev 11:480-96. 1998
    ..A major challenge for public health officials in all tropical areas of the world is to develop and implement sustainable prevention and control programs that will reverse the trend of emergent dengue hemorrhagic fever...
  38. ncbi Seroprevalence and risk factors for dengue infection in socio-economically distinct areas of Recife, Brazil
    Cynthia Braga
    Centro de Pesquisas Aggeu Magalhaes, Fundacao Oswaldo Cruz, Av Professor Moraes Rego, S N, Cidade Universitaria, CEP 50670 420, Recife, PE, Brazil
    Acta Trop 113:234-40. 2010
    ..In the deprived area, 59% of children had already been exposed to dengue virus by the age of 5 years and the estimated force of infection was three times higher than that in the privileged ..
  39. ncbi Serotype-specific differences in the risk of dengue hemorrhagic fever: an analysis of data collected in Bangkok, Thailand from 1994 to 2006
    Jessica R Fried
    Mahidol Oxford Tropical Medicine Research Unit MORU, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    PLoS Negl Trop Dis 4:e617. 2010
    ..It is unclear whether dengue serotypes differ in their propensity to cause severe disease. We analyzed differences in serotype-specific disease severity in children presenting for medical attention in Bangkok, Thailand...
  40. ncbi Dengue virus capsid protein usurps lipid droplets for viral particle formation
    Marcelo M Samsa
    Fundación Instituto Leloir CONICET, Buenos Aires, Argentina
    PLoS Pathog 5:e1000632. 2009
    b>Dengue virus is responsible for the highest rates of disease and mortality among the members of the Flavivirus genus. Dengue epidemics are still occurring around the world, indicating an urgent need of prophylactic vaccines and antivirals...
  41. ncbi A protective role for dengue virus-specific CD8+ T cells
    Lauren E Yauch
    Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    J Immunol 182:4865-73. 2009
    Infection with one of the four serotypes of dengue virus (DENV1-4) can result in a range of clinical manifestations in humans, from dengue fever to the more serious dengue hemorrhagic fever/dengue shock syndrome...
  42. ncbi Identification of a recombinant dengue virus type 1 with 3 recombination regions in natural populations in Guangdong province, China
    S P Chen
    State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, No 20 Dongdajie Street, Fengtai District, Beijing 100071, China
    Arch Virol 153:1175-9. 2008
    Using recombination analysis, we identified a recombinant dengue virus type 1 strain, namely, GD23/95, with three recombination regions, located within the sequences of the prM/E junction, NS1, and NS3, respectively...
  43. ncbi Dengue virus infectivity depends on envelope protein binding to target cell heparan sulfate
    Y Chen
    Department of Internal Medicine, University of Michigan, Ann Arbor 48109, USA
    Nat Med 3:866-71. 1997
    b>Dengue virus is a human pathogen that has reemerged as an increasingly important public health threat...
  44. ncbi NS5 of dengue virus mediates STAT2 binding and degradation
    Joseph Ashour
    Department of Microbiology, Emerging Pathogens Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Virol 83:5408-18. 2009
    ..b>Dengue virus (DENV) encodes several proteins (NS2a, NS4a, and NS4b) that have been shown individually to inhibit the IFN ..
  45. ncbi A mouse-passaged dengue virus strain with reduced affinity for heparan sulfate causes severe disease in mice by establishing increased systemic viral loads
    Tyler R Prestwood
    Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, California 92037, USA
    J Virol 82:8411-21. 2008
    The four serotypes of dengue virus (DENV1 to DENV4) cause extensive morbidity and mortality. A major obstacle to studying disease pathogenesis and developing therapies has been the lack of a small-animal model...
  46. ncbi Structural and functional studies of the promoter element for dengue virus RNA replication
    Maria F Lodeiro
    Fundacion Instituto Leloir, Buenos Aires, Argentina
    J Virol 83:993-1008. 2009
    The 5' untranslated region (5'UTR) of the dengue virus (DENV) genome contains two defined elements essential for viral replication. At the 5' end, a large stem-loop (SLA) structure functions as the promoter for viral polymerase activity...
  47. ncbi Flavivirus induces interferon-beta gene expression through a pathway involving RIG-I-dependent IRF-3 and PI3K-dependent NF-kappaB activation
    Tsung Hsien Chang
    Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan, ROC
    Microbes Infect 8:157-71. 2006
    In this study, we found that infection with flaviviruses, such as Japanese encephalitis virus (JEV) and dengue virus serotype 2 (DEN-2), leads to interferon-beta (IFN-beta) gene expression in a virus-replication- and de novo protein-..
  48. ncbi An antigen capture enzyme-linked immunosorbent assay reveals high levels of the dengue virus protein NS1 in the sera of infected patients
    P R Young
    Sir Albert Sakzewski Virus Research Centre, The Royal Children s Hospital, Herston, Brisbane 4029, Australia
    J Clin Microbiol 38:1053-7. 2000
    We describe the development of a capture enzyme-linked immunosorbent assay for the detection of the dengue virus nonstructural protein NS1...
  49. ncbi Identification of GRP 78 (BiP) as a liver cell expressed receptor element for dengue virus serotype 2
    S Jindadamrongwech
    Molecular Pathology Laboratory, Institute of Molecular Biology and Genetics, Mahidol University, Nakorn Pathom, Thailand
    Arch Virol 149:915-27. 2004
    This study sought to identify receptor elements for dengue virus serotype 2 on human liver cells (HepG2) using the viral overlay protein binding assay (VOPBA) technique and Mass Spectrometry fingerprinting...
  50. ncbi Recent advances in deciphering viral and host determinants of dengue virus replication and pathogenesis
    Karen Clyde
    Division of Infectious Diseases, School of Public Health, 140 Warren Hall, University of California, Berkeley, Berkeley, CA 94720-7360, USA
    J Virol 80:11418-31. 2006
  51. ncbi Stable introduction of a life-shortening Wolbachia infection into the mosquito Aedes aegypti
    Conor J McMeniman
    School of Integrative Biology, University of Queensland, Brisbane 4072, Australia
    Science 323:141-4. 2009
    ..Our data suggest that targeting mosquito age with inherited Wolbachia infections may be a viable strategy to reduce the transmission of pathogens such as dengue viruses...
  52. ncbi Dendritic cell-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN)-mediated enhancement of dengue virus infection is independent of DC-SIGN internalization signals
    Pierre Yves Lozach
    Unite d Immunologie Virale, Institut Pasteur Paris, 25 28, rue du Dr Roux, 75724 Paris Cedex 15, France
    J Biol Chem 280:23698-708. 2005
    b>Dengue virus (DV) is a mosquito-borne flavivirus that causes hemorrhagic fever in humans...
  53. ncbi Serotype-specific detection of dengue viruses in a fourplex real-time reverse transcriptase PCR assay
    Barbara W Johnson
    Diagnostic and Reference Laboratory, Arbovirus Diseases Branch, Division of Vector Borne Infectious Diseases, Centers for Disease Control and Prevention, 3150 Rampart Rd, Fort, Collins, CO 80521
    J Clin Microbiol 43:4977-83. 2005
    ....
  54. ncbi Enzyme-linked immunosorbent assay specific to Dengue virus type 1 nonstructural protein NS1 reveals circulation of the antigen in the blood during the acute phase of disease in patients experiencing primary or secondary infections
    Sophie Alcon
    Unité des Arbovirus et Virus des Fièvres Hémorragiques, Institut Pasteur, 75724 Paris Cedex 15, France
    J Clin Microbiol 40:376-81. 2002
    ..vivo, we developed a sensitive enzyme-linked immunosorbent assay (ELISA) to detect the protein in the sera of dengue virus-infected patients...
  55. ncbi Pathogenesis of flavivirus infections: using and abusing the host cell
    Maria Dolores Fernandez-Garcia
    Unité Pathogénie Virale, INSERM U819, Institut Pasteur, Departement de Virologie, Paris, France
    Cell Host Microbe 5:318-28. 2009
    Flaviviruses, such as the dengue virus and the West Nile virus, are emerging arthropod-borne viruses that represent an immense global health problem...
  56. ncbi Translation elongation factor-1alpha, La, and PTB interact with the 3' untranslated region of dengue 4 virus RNA
    Monica De Nova-Ocampo
    Departamento de Biomedicina Molecular, Centro de Investigacion y de Estudios Avanzados del IPN, Mexico City 07360, Mexico
    Virology 295:337-47. 2002
    ..The latter are duplicated (CS2A and CS2B) in DEN4. Dengue virus replication, like that of other RNA viruses, might involve the cis-elements located within the 3'UTR and the ..
  57. ncbi Evaluation of two new commercial tests for the diagnosis of acute dengue virus infection using NS1 antigen detection in human serum
    Philippe Dussart
    Centre National de Référence des Arbovirus et Virus Influenza, Région Antilles Guyane, Institut Pasteur de la Guyane, Cayenne, French Guiana
    PLoS Negl Trop Dis 2:e280. 2008
    ..performance of two new commercial tests for the detection of dengue NS1 protein during the clinical phase of dengue virus (DENV) infection-an immunochromatographic test allowing rapid detection of the NS1 antigen, Dengue NS1 Ag STRIP ..
  58. ncbi Cytokine cascade in dengue hemorrhagic fever: implications for pathogenesis
    U C Chaturvedi
    Department of Microbiology, Faculty of Medicine, Kuwait University, Safat, Kuwait
    FEMS Immunol Med Microbiol 28:183-8. 2000
    b>Dengue virus produces a mild acute febrile illness, dengue fever (DF) and a severe illness, dengue hemorrhagic fever (DHF)...
  59. ncbi Dengue-virus-infected dendritic cells trigger vascular leakage through metalloproteinase overproduction
    Natthanej Luplertlop
    , IRD, , UR178 IFR122, 34094 Montpellier, France
    EMBO Rep 7:1176-81. 2006
    b>Dengue virus (DV) is an important re-emerging arthropod-borne virus of global significance...
  60. ncbi Humanized mice show clinical signs of dengue fever according to infecting virus genotype
    Javier Mota
    Department of Virology and Immunology, Southwest Foundation for Biomedical Research, San Antonio, TX 78227, USA
    J Virol 83:8638-45. 2009
    ..of humanized NOD-scid IL2r gamma(null) mice with different strains (representing the four genotypes) of dengue virus serotype 2 (DEN-2) can induce the development of human-like disease, including fever, viremia, erythema, and ..
  61. ncbi Human TLR3 recognizes dengue virus and modulates viral replication in vitro
    Yi Ting Tsai
    Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan
    Cell Microbiol 11:604-15. 2009
    ..This study aims at the interaction between dengue virus (DENV) and human TLRs at the incipient stage of infection in vitro...
  62. ncbi Molecular evolution of dengue viruses: contributions of phylogenetics to understanding the history and epidemiology of the preeminent arboviral disease
    Scott C Weaver
    Department of Pathology, Center for Tropical Diseases, University of Texas Medical Branch, Galveston, TX 77555 0609, USA
    Infect Genet Evol 9:523-40. 2009
    ....
  63. ncbi Inferring the rate and time-scale of dengue virus evolution
    S Susanna Twiddy
    Department of Zoology, University of Oxford, Oxford, United Kingdom
    Mol Biol Evol 20:122-9. 2003
    ..To understand the rate at which genetic diversification occurs in dengue virus and to infer the time-scale of its evolution, we employed a maximum likelihood method that uses information ..
  64. ncbi Lineage extinction and replacement in dengue type 1 virus populations are due to stochastic events rather than to natural selection
    Hlaing Myat Thu
    School of Life Sciences, Queensland University of Technology, 2, George Street, Brisbane 4001, Australia
    Virology 336:163-72. 2005
    Between 1996 and 1998, two clades (B and C; genotype I) of dengue virus type 1 (DENV-1) appeared in Myanmar (Burma) that were new to that location...
  65. ncbi Small RNA profiling of Dengue virus-mosquito interactions implicates the PIWI RNA pathway in anti-viral defense
    Ann M Hess
    Department of Statistics, Colorado State University, Fort Collins, Colorado 80523, USA
    BMC Microbiol 11:45. 2011
    ..aegypti, we deep-sequenced small non-coding RNAs. Triplicate biological replicates were used so that rigorous statistical metrics could be applied...
  66. ncbi Aedes aegypti vectorial capacity is determined by the infecting genotype of dengue virus
    Justin R Anderson
    Department of Virology and Immunology, Southwest Foundation for Biomedical Research, San Antonio, Texas 78245-0549, USA
    Am J Trop Med Hyg 75:886-92. 2006
    ..This much earlier appearance of dengue virus in salivary glands resulted in an estimated 2- to 65-fold increase in the vectorial capacity of these ..
  67. ncbi Antibody neutralization and viral virulence in recurring dengue virus type 2 outbreaks
    Sook San Wong
    Macfarlane Burnet Institute for Medical Research and Public Health Limited, Melbourne, Australia
    Viral Immunol 20:359-68. 2007
    ..Two cycles of outbreaks involving dengue virus type 2 (DENV-2) of the same genotype occurred in the 1990s in the Klang Valley, Malaysia...
  68. ncbi First case of Dengue virus infection in Nepal
    Basu Dev Pandey
    Sukra Raj Tropical and Infectious Diseases Hospital, Teku, Kathmandu, Nepal
    Nepal Med Coll J 6:157-9. 2004
    b>Dengue virus transmitted by Aedes mosquito is one of the important cause health problems in world...
  69. ncbi Antibody responses are generated to immunodominant ELK/KLE-type motifs on the nonstructural-1 glycoprotein during live dengue virus infections in mice and humans: implications for diagnosis, pathogenesis, and vaccine design
    Andrew K I Falconar
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, UK
    Clin Vaccine Immunol 14:493-504. 2007
    ..The core LX1 epitope (113YSWKTWG119), identified by the dengue virus complex-specific monoclonal antibody (MAb) 3D1...
  70. ncbi Concurrent infection with dengue virus type-2 and DENV-3 in a patient from Ceará, Brazil
    Fernanda Montenegro de Carvalho Araújo
    Laboratório Central de Saude Pública do Ceará, Fortaleza, CE, Brasil
    Mem Inst Oswaldo Cruz 101:925-8. 2006
    Dengue outbreaks have occurred in several regions in Brazil and cocirculating dengue virus type 1 (DENV-1), DENV-2, and DENV-3 have been frequently observed...
  71. ncbi Dengue virus infects macrophages and dendritic cells in a mouse model of infection
    Jennifer L Kyle
    Division of Infectious Diseases, School of Public Health, University of California, Berkeley, CA 94720 7360, USA
    J Infect Dis 195:1808-17. 2007
    ..We find that the initial cellular tropism of DENV in mice is similar to that reported in humans, thereby paving the way for investigation of cellular tropism and pathogenesis of DENV in primary and secondary infections...
  72. ncbi Characterization of humoral and cellular immune responses in cynomolgus macaques upon primary and subsequent heterologous infections with dengue viruses
    Penelopie Koraka
    Department of Virology, Erasmus MC, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    Microbes Infect 9:940-6. 2007
    Since studying the pathogenesis of dengue virus associated disease in humans has several limitations, an appropriate animal model is needed...
  73. ncbi Evidence of vertical transmission of dengue virus in two endemic localities in the state of Oaxaca, Mexico
    Jeannette Günther
    Programa Institucional de Biomedicina Molecular, Escuela Nacional de Medicina y Homeopatía, Instituto Politecnico Nacional, Mexico City, Mexico
    Intervirology 50:347-52. 2007
    b>Dengue virus is spread in tropical areas of the world and is the causative agent of dengue fever and dengue hemorrhagic fever...
  74. ncbi Dengue in travelers
    Annelies Wilder-Smith
    Travellers' Health and Vaccination Centre, Tan Tock Seng Hospital, Singapore
    N Engl J Med 353:924-32. 2005
  75. ncbi [Diagnostic tests: Dengue virus]
    Mikako Ito
    Department of Virology 1, National Institute of Infectious Disease
    Nippon Rinsho 63:313-7. 2005
  76. ncbi Dengue virus infection and immune response in humanized RAG2(-/-)gamma(c)(-/-) (RAG-hu) mice
    Jes G Kuruvilla
    Department of Microbiology, Immunology and Pathology, 1619 Campus Delivery, Colorado State University, Fort Collins, CO 80523 1619, USA
    Virology 369:143-52. 2007
    ..Sera from some of the infected mice were also found to be capable of dengue virus neutralization...
  77. ncbi Antigenic cell associated dengue 2 virus proteins detected in vitro using dengue fever patients sera
    Sazaly AbuBakar
    Department of Medical Microbiology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
    Malays J Pathol 24:29-36. 2002
    ..b>Dengue virus envelope (E), premembrane (PrM) and non-structural protein 1 (NS 1) dimer were detected beginning on day 3 ..
  78. ncbi Primary and secondary infections of Macaca fascicularis monkeys with Asian and American genotypes of dengue virus 2
    Lidice Bernardo
    Department of Virology, PAHO WHO Collaborating Center for the Study of Dengue and its Vector, Pedro Kouri Tropical Medicine Institute, Autopista Novia del Mediodia, km 6 1 2, P O Box 601, Marianao 13, Havana, Cuba
    Clin Vaccine Immunol 15:439-46. 2008
    The goal of this study was to compare the immune response and the protection capacity induced by the dengue virus 2 (DENV-2) American and Asian genotypes in Macaca fascicularis monkeys...
  79. ncbi Dengue and dengue hemorrhagic fever among adults: clinical outcomes related to viremia, serotypes, and antibody response
    Adriana O Guilarde
    Instituto de Patologia Tropical e Saude Publica, Universidade Federal de Goias, Brazil
    J Infect Dis 197:817-24. 2008
    ..In Brazil, the disease burden predominantly affects adults, with an increasing trend toward progression to dengue hemorrhagic fever (DHF) noted...
  80. ncbi [Molecular evolution of dengue virus: a necessary field of research]
    Germán Añez
    Invest Clin 48:273-6. 2007
    ..Genomics seems to be an important tool to achieve this objective and to help to develop required therapeutics and prophylactic strategies in a short time...
  81. ncbi Serological and entomological investigations of an outbreak of dengue fever in certain rural areas of Kanyakumari district, Tamil Nadu
    R Paramasivan
    Centre for Research in Medical Entomology ICMR, Madurai, India
    Indian J Med Res 123:697-701. 2006
    ..Since the fever outbreak occurred for the first time in these villages, serological, virological and entomological investigations were carried out to confirm the aetiology of outbreak...
  82. ncbi Autoimmune pathogenesis in dengue virus infection
    Chiou Feng Lin
    Department of Microbiology and Immunology, National Cheng Kung University Medical College, Tainan, Taiwan
    Viral Immunol 19:127-32. 2006
    The pathogenic mechanisms of dengue hemorrhagic fever and dengue shock syndrome (DHF/DSS) caused by dengue virus (DV) infection remain unresolved...
  83. ncbi DNA vaccines against dengue virus based on the ns1 gene: the influence of different signal sequences on the protein expression and its correlation to the immune response elicited in mice
    S M Costa
    Laboratory of Immunopathology, Department of Bichemistry and Molecular Biology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Av Brasil 4365, Pav Leonidas Deane, s 204, Rio de Janeiro, RJ, CEP 21040 900, Brazil
    Virology 358:413-23. 2007
    ..Protection against DENV-2 was verified in pcTPANS1- and pcENS1-immunized mice, although the plasmid pcTPANS1 induced slight higher protective immunity. These plasmids seem to activate distinct patterns of the immune system...
  84. ncbi Vaccine candidates for dengue virus type 1 (DEN1) generated by replacement of the structural genes of rDEN4 and rDEN4Delta30 with those of DEN1
    Joseph E Blaney
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Virol J 4:23. 2007
    Antigenic chimeric viruses have previously been generated in which the structural genes of recombinant dengue virus type 4 (rDEN4) have been replaced with those derived from DEN2 or DEN3...
  85. ncbi [Dengue and dengue hemorrhagic fever: research priorities]
    Maria G Guzman
    Instituto de Medicina Tropical Pedro Kouri, Ciudad de La Habana, Cuba
    Rev Panam Salud Publica 19:204-15. 2006
    ....
  86. ncbi [Dengue, a growing problem of health in the Americas]
    Gustavo Kouri
    Rev Panam Salud Publica 19:143-5. 2006
  87. ncbi Vascular leakage in severe dengue virus infections: a potential role for the nonstructural viral protein NS1 and complement
    Panisadee Avirutnan
    Medical Molecular Biology Unit, Siriraj Hospital, Mahidol University, Bangkok, Thailand
    J Infect Dis 193:1078-88. 2006
    ..Thirty years ago, complement activation was proposed to be a key underlying event, but the cause of complement activation has remained unknown...
  88. ncbi Laboratory-based dengue fever surveillance in Tamil Nadu, India
    T John Victor
    Institute of Vector Control and Zoonoses, Hosur, India
    Indian J Med Res 126:112-5. 2007
    ..Although the existence of all the four serotypes of dengue virus was proved as early as in 1960s, it was only after 1990, several outbreaks of DF/DHF were reported in Tamil ..
  89. ncbi Four dengue virus serotypes found circulating during an outbreak of dengue fever and dengue haemorrhagic fever in Jakarta, Indonesia, during 2004
    Agus Suwandono
    National Institute of Health Research and Development, Ministry of Health, Jakarta, Indonesia
    Trans R Soc Trop Med Hyg 100:855-62. 2006
    ..Clinical and laboratory findings were determined from a cohort of 272 hospitalised patients. Exposure to dengue virus was determined in 180 (66.2%) patients. When clinically assessed, 100 (55...
  90. ncbi Induction of neutralizing antibodies specific to dengue virus serotypes 2 and 4 by a bivalent antigen composed of linked envelope domains III of these two serotypes
    Saima Khanam
    International Centre for Genetic Engineering and Biotechnology, New Delhi, India
    Am J Trop Med Hyg 74:266-77. 2006
    ..In this study, which has been prompted by the emergence of dengue virus envelope domain III as a promising sub-unit vaccine candidate, we have examined the possibility of developing a ..
  91. ncbi Use of capillary blood samples as a new approach for diagnosis of Dengue virus infection
    Severine Matheus
    Centre National de Référence des Arbovirus, Institut Pasteur de la Guyane, 23 avenue Pasteur, BP 6010, 97306 Cayenne Cedex, French Guiana
    J Clin Microbiol 45:887-90. 2007
    We evaluated the use of capillary blood samples stored on filter papers for diagnosis of dengue virus infection. Venous and capillary blood samples were collected from 130 patients suspected of having dengue fever...
  92. ncbi Identification of all dengue serotypes in Nepal
    Sarala Malla
    Emerg Infect Dis 14:1669-70. 2008
  93. ncbi DNA priming E and NS1 constructs--homologous proteins boosting immunization strategy to improve immune response against dengue in mice
    Gabriela Mellado-Sanchez
    Departamento de Biomedicina Molecular Centro de Investigación y Estudios Avanzadas del IPN, Mexico, DF Mexico
    Viral Immunol 18:709-21. 2005
    ..In this work, two recombinant plasmids were used, one encoding for the dengue virus E protein, which is know to induce neutralizing antibodies (pcDNA 3...
  94. ncbi Immunopathological mechanisms in dengue and dengue hemorrhagic fever
    Sharone Green
    University of Massachusetts Medical School, Center for Infectious Disease and Vaccine Research, Worcester, Massachusetts 01655, USA
    Curr Opin Infect Dis 19:429-36. 2006
    PURPOSE OF REVIEW: The continued emergence of dengue virus infection and its severe disease manifestation, dengue hemorrhagic fever, is a growing public health problem...
  95. ncbi Study of sequence variation of dengue type 3 virus in naturally infected mosquitoes and human hosts: implications for transmission and evolution
    Su-Ru Lin
    Institute of Microbiology, College of Medicine, National Taiwan University, No. 1 Sec. 1 Jen-Ai Rd, Taipei, Taiwan
    J Virol 78:12717-21. 2004
    b>Dengue virus is an arbovirus that replicates alternately in the mosquito vector and human host...
  96. ncbi Dengue viral infections
    G N Malavige
    Department of Clinical Immunology, A Floor, West Block, Queens Medical Centre, University Hospital, Nottingham NG7 2UH, UK
    Postgrad Med J 80:588-601. 2004
    ..This review outlines aspects of the epidemiology of dengue infections, the dengue virus and its mosquito vector, clinical features and pathogenesis of dengue infections, and the management and ..
  97. ncbi A live attenuated recombinant dengue-4 virus vaccine candidate with restricted capacity for dissemination in mosquitoes and lack of transmission from vaccinees to mosquitoes
    J M Troyer
    Department of Entomology, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, USA
    Am J Trop Med Hyg 65:414-9. 2001
    ..Most significantly, 2Adelta30 was not transmitted to 352 Ae. albopictus mosquitoes fed on 10 vaccinees, all of whom were infected with the vaccine candidate...
  98. ncbi Vaccine candidates derived from a novel infectious cDNA clone of an American genotype dengue virus type 2
    Joseph E Blaney
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 USA
    BMC Infect Dis 4:39. 2004
    A dengue virus type 2 (DEN-2 Tonga/74) isolated from a 1974 epidemic was characterized by mild illness and belongs to the American genotype of DEN-2 viruses...
  99. ncbi A single amino acid substitution in the envelope protein of chimeric yellow fever-dengue 1 vaccine virus reduces neurovirulence for suckling mice and viremia/viscerotropism for monkeys
    F Guirakhoo
    Acambis, Inc, 38 Sidney St, Cambridge, MA 02139, USA
    J Virol 78:9998-10008. 2004
    ..These changes may be responsible for virus attenuation through a change in the pH threshold for virus envelope fusion with the host cell membrane...
  100. ncbi Control of aedes vectors of dengue in three provinces of Vietnam by use of Mesocyclops (Copepoda) and community-based methods validated by entomologic, clinical, and serological surveillance
    Brian H Kay
    Queensland Institute of Medical Research and University of Queensland Tropical Health Program, Brisbane, Australia
    Am J Trop Med Hyg 66:40-8. 2002
    ..Variable dengue attack rates made the clinical and serological comparison of control and untreated communes problematic, but these data indicate that clinical surveillance by itself is inadequate to monitor dengue transmission...
  101. ncbi Efficiency of dengue serotype 2 virus strains to infect and disseminate in Aedes aegypti
    Philip M Armstrong
    Department of Virology and Immunology, Southwest Foundation for Biomedical Research, San Antonio, Texas 78245 0549, USA
    Am J Trop Med Hyg 68:539-44. 2003
    ..Together, these findings suggest that Ae. aegypti tends to be more susceptible to infection by DEN-2 viruses of the SE Asian genotype than to those of the American genotype, and this may have epidemiologic implications...

Research Grants84

  1. Dengue Epitope Vaccine,Tetravalent & MHCII-Targeted
    J Thomas August; Fiscal Year: 2007
    ..The vaccine constructs will be validated for human dengue virus specific T- and B-cell responses by the human ex vivo assay system (Project 2), and by mouse immunization for ..
  2. Host factors involved in viral RNA recombination
    Peter Nagy; Fiscal Year: 2006
    ..has been demonstrated to occur for a large number of human, animal and plant viruses, including poliovirus, dengue virus, infectious bronchitis virus, influenza A virus, hantavirus, hepatitis D virus, Human Respiratory Syncytial ..
  3. Inhibition of the Membrane Fusion Proteins of Flaviviruses and Alphaviruses
    Margaret Kielian; Fiscal Year: 2007
    ..b>Dengue virus (DV) is currently of particular concern as it has dramatically reemerged to become endemic in more than 100 ..
  4. A HTS Assay for Identifying Anti-Viral Drugs Against Arbovirus Infections
    Qianjun Li; Fiscal Year: 2007
    ..Several recent human and/or animal epidemics are caused by arboviruses, including Dengue virus (DNV) in Asia, West Nile virus (WNV) in North America and Bluetongue virus (BTV) in Europe...
  5. Yellow Fever/Dengue Virus Competence in Aedes aegypt aegypti/formosus in Senegal
    William Black; Fiscal Year: 2009
    ..l.) is the primary vector to humans of yellow fever virus (YFV) and the four serotypes of dengue virus (DENV1-4)...
  6. Yellow Fever/Dengue Virus Competence in Aedes aegypt aegypti/formosus in Senegal
    William C Black; Fiscal Year: 2010
    ..l.) is the primary vector to humans of yellow fever virus (YFV) and the four serotypes of dengue virus (DENV1-4)...
  7. Antiviral potential of helicase inhibitors
    David N Frick; Fiscal Year: 2010
    ..RNA viruses, focusing on pathogens with abnormally high global burdens of disease: hepatitis C virus (HCV), Dengue virus (DENV), West Nile virus (WNV), Japanese encephalitis virus (JEV), yellow fever virus (YFV), and human ..
  8. Role of an essential RNA chaperone in virus replication
    Peter Nagy; Fiscal Year: 2006
    ..numerous other important human and animal viruses (hepatitis C virus, flavivirus, including West Nile virus and dengue virus, pestiviruses) and plant viruses (luteo- and carmoviruses), understanding the mechanism of RNA replication in ..
  9. MOLECULAR BIOLOGY OF POLIOVIRUS RNA REPLICATION
    JAMES FLANEGAN; Fiscal Year: 2007
    ..RNA viruses that form a large group of important human pathogens include hepatitis C virus, West Nile virus, dengue virus and the SARS-associated coronavirus...
  10. MOLECULAR BIOLOGY OF POLIOVIRUS RNA REPLICATION
    James Bert Flanegan; Fiscal Year: 2010
    ..RNA viruses that form a large group of important human pathogens include hepatitis C virus, West Nile virus, dengue virus and the SARS-associated coronavirus...
  11. MOLECULAR BIOLOGY OF POLIOVIRUS RNA REPLICATION
    JAMES FLANEGAN; Fiscal Year: 2009
    ..RNA viruses that form a large group of important human pathogens include hepatitis C virus, West Nile virus, dengue virus and the SARS-associated coronavirus...
  12. FUNCTIONAL ANALYSIS OF DENGUE VIRUS ANTIGENS NS3 AND NS5
    Radhakrishnan Padmanabhan; Fiscal Year: 1993
    ..Dengue is a human disease caused by the mosquito-borne dengue virus.Apart from dengue fever, a more severe and fatal form of the disease occurs in children called dengue ..
  13. MOLECULAR BIOLOGY OF POLIOVIRUS RNA REPLICATION
    JAMES FLANEGAN; Fiscal Year: 2006
    ..RNA viruses that form a large group of important human pathogens include hepatitis C virus, West Nile virus, dengue virus and the SARS-associated coronavirus...
  14. Determinants of RNA virus evolution
    ISABEL NOVELLA; Fiscal Year: 2009
    ..and C viruses, HIV, influenza virus, most of the cold viruses, rabies virus, Ebola virus, West Nile virus, and dengue virus. We face major difficulties in controlling these viral diseases because of the viruses' escape from immune ..
  15. Determinants of RNA virus evolution
    ISABEL NOVELLA; Fiscal Year: 2007
    ..and C viruses, HIV, influenza virus, most of the cold viruses, rabies virus, Ebola virus, West Nile virus, and dengue virus. We face major difficulties in controlling these viral diseases because of the viruses' escape from immune ..
  16. Recombinant antigen assays for Lassa and other arenaviru
    Robert Garry; Fiscal Year: 2005
    ..a deliberate release, and allow the virus used to be distinguished from other hemorrhagic fever viruses such as dengue virus or Ebola virus that may have similar case presentations...
  17. INTERFERENCE TO DENGUE VIRUS REPLICATION IN MOSQUITOES
    Carol Blair; Fiscal Year: 2001
    ..In toto, this work should give us significant understanding of which anti-DEN virus strategies are important for ultimately generating transgenic mosquitoes that are resistant to DEN virus infections. ..
  18. Arbovirus quasispecies-impact of arthropod transmission
    GREGORY EBEL; Fiscal Year: 2004
    ..RNA viruses, such as West Nile virus, Dengue virus, Rift Valley fever virus and Venezuelan Equine Encephalitis virus, exist within each host as a genetically ..
  19. MOLECULAR ANALYSIS OF ALPHAVIRUS MEMBRANE FUSION PROTEIN
    Margaret Kielian; Fiscal Year: 2010
    ..such as the encephalitic alphaviruses and the flaviviruses West Nile, yellow fever, Japanese encephalitis and dengue virus (DV)...
  20. MOLECULAR ANALYSIS OF ALPHAVIRUS MEMBRANE FUSION PROTEIN
    Margaret Kielian; Fiscal Year: 2009
    ..such as the encephalitic alphaviruses and the flaviviruses West Nile, yellow fever, Japanese encephalitis and dengue virus (DV)...
  21. A VEE Replicon-Based Vaccine for Dengue Virus
    Laura White; Fiscal Year: 2006
    b>Dengue virus (DEN), a priority "A" pathogen on the NIH/CDC list of bioterrorism related and emerging pathogens, infects humans causing a spectrum of clinical manifestations including dengue fever, dengue hemorrhagic fever and dengue shock ..
  22. Yeast-Based High-throughput Assays for Proteases of Category A, B, & C Viruses
    Hong Fang; Fiscal Year: 2007
    ..In the proposed studies, we will develop yeast assays for proteases produced by seven RNA viruses: Dengue Virus, West Nile Virus, Japanese Encephalitis Virus, Yellow Fever Virus, Hepatitis A Virus, SARS coronavirus, and ..
  23. Yeast-Based High-throughput Assays for Proteases of Category A, B, & C Viruses
    Hong Fang; Fiscal Year: 2009
    ..In the proposed studies, we will develop yeast assays for proteases produced by seven RNA viruses: Dengue Virus, West Nile Virus, Japanese Encephalitis Virus, Yellow Fever Virus, Hepatitis A Virus, SARS coronavirus, and ..
  24. Broad-Spectrum Therapeutic Human Antibodies for Dengue Virus Infections
    Yorgo Modis; Fiscal Year: 2006
    ..epitopes can prevent and treat infection by several different flaviviruses, including all 4 serotypes of dengue virus and West Nile virus (WNV). Passive immunization is an accepted medical practice to protect against infection...
  25. FUNCTIONAL ANALYSIS OF DENGUE VIRUS ANTIGENS NS3 AND NS5
    Radhakrishnan Padmanabhan; Fiscal Year: 2003
    ..To study the mechanism of replication in the absence of virion assembly, a subgenomic dengue virus replicon expressing a readily quantifiable reporter gene product will be constructed. 3...
  26. Lethal Mutagenesis as an Antiviral Strategy
    Craig Cameron; Fiscal Year: 2007
    ..Establish dengue virus type 2 as a model system for evaluation of lethal mutagenesis by characterizing the mechanism of action of ..
  27. Structure and Function of Flaviviruses
    Michael G Rossmann; Fiscal Year: 2010
    ..This structure has made it possible to build pseudo-atomic models of immature dengue virus and of a low pH intermediate prior to the release of the pr polypeptide and maturation into infectious ..
  28. Apoptosis as an anti-viral response in mosquito midgut
    ROLLIE CLEM; Fiscal Year: 2007
    ..are important vectors for a number of infectious diseases caused by arboviruses including West Nile virus, dengue virus, yellow fever virus, LaCrosse virus, and Venezuelan, eastern and western equine encephalitis viruses...