hantaan virus

Summary

Summary: The type species of the genus HANTAVIRUS infecting the rodent Apodemus agrarius and humans who come in contact with it. It causes syndromes of hemorrhagic fever associated with vascular and especially renal pathology.

Top Publications

  1. pmc Pathogenic hantaviruses Andes virus and Hantaan virus induce adherens junction disassembly by directing vascular endothelial cadherin internalization in human endothelial cells
    Elena Gorbunova
    Department of Molecular Genetics and Microbiology, Stony Brook University, Life Sciences Room 126, Stony Brook, NY 11794 5222, USA
    J Virol 84:7405-11. 2010
  2. ncbi Inactivation of Hantaan virus-containing samples for subsequent investigations outside biosafety level 3 facilities
    Annette A Kraus
    Institut fur Virologie, Charite, Universitatsmedizin Berlin, Campus Charite Mitte, Berlin, Germany
    Intervirology 48:255-61. 2005
  3. doi A Phase 1 clinical trial of Hantaan virus and Puumala virus M-segment DNA vaccines for hemorrhagic fever with renal syndrome
    Ellen F Boudreau
    US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD, United States
    Vaccine 30:1951-8. 2012
  4. doi Cellular immune response to Hantaan virus nucleocapsid protein in the acute phase of hemorrhagic fever with renal syndrome: correlation with disease severity
    Meiliang Wang
    Department of Immunology, Tangdu Hospital, Fourth Military Medical University, Xi an, China
    J Infect Dis 199:188-95. 2009
  5. pmc Structural studies of Hantaan virus
    Anthony J Battisti
    Department of Biological Sciences, Purdue University, 915 W State Street, West Lafayette, IN 47907 2054, USA
    J Virol 85:835-41. 2011
  6. pmc Landscape elements and Hantaan virus-related hemorrhagic fever with renal syndrome, People's Republic of China
    Lei Yan
    State Key Laboratory of Remote Sensing Science, IRSA CAS, Beijing, People s Republic of China
    Emerg Infect Dis 13:1301-6. 2007
  7. pmc Hantavirus causing hemorrhagic fever with renal syndrome enters from the apical surface and requires decay-accelerating factor (DAF/CD55)
    Ellen Krautkrämer
    Department of Nephrology, University of Heidelberg, Im Neuenheimer Feld 162, D 69120 Heidelberg, Germany
    J Virol 82:4257-64. 2008
  8. doi Genetic susceptibility to haemorrhagic fever with renal syndrome caused by Hantaan virus in Chinese Han population
    M L Wang
    Department of Immunology, Fourth Military Medical University, 17 Changle West Road, Xi an, China
    Int J Immunogenet 36:227-9. 2009
  9. doi Dysregulation of the β3 integrin-VEGFR2 complex in Hantaan virus-directed hyperpermeability upon treatment with VEGF
    Wei Wang
    Center of Infectious Diseases, Tangdu Hospital, The Fourth Military Medical University, Xi an, China
    Arch Virol 157:1051-61. 2012
  10. pmc Identification of three novel CTL epitopes within nucleocapsid protein of Hantaan virus
    Meiliang Wang
    Center for Experimental Medicine, Lanzhou General Hospital, Lanzhou Military Command, Lanzhou, China
    Viral Immunol 24:449-54. 2011

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Scientific Experts

Detail Information

Publications192 found, 100 shown here

  1. pmc Pathogenic hantaviruses Andes virus and Hantaan virus induce adherens junction disassembly by directing vascular endothelial cadherin internalization in human endothelial cells
    Elena Gorbunova
    Department of Molecular Genetics and Microbiology, Stony Brook University, Life Sciences Room 126, Stony Brook, NY 11794 5222, USA
    J Virol 84:7405-11. 2010
    ..and the internalization of VE-cadherin within endothelial cells infected by pathogenic Andes virus (ANDV) and Hantaan virus (HTNV) and nonpathogenic Tula virus (TULV) hantaviruses...
  2. ncbi Inactivation of Hantaan virus-containing samples for subsequent investigations outside biosafety level 3 facilities
    Annette A Kraus
    Institut fur Virologie, Charite, Universitatsmedizin Berlin, Campus Charite Mitte, Berlin, Germany
    Intervirology 48:255-61. 2005
    ....
  3. doi A Phase 1 clinical trial of Hantaan virus and Puumala virus M-segment DNA vaccines for hemorrhagic fever with renal syndrome
    Ellen F Boudreau
    US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD, United States
    Vaccine 30:1951-8. 2012
    ..These results demonstrate that the HTNV and PUUV DNA vaccines are safe and can be immunogenic in humans when delivered by PMED...
  4. doi Cellular immune response to Hantaan virus nucleocapsid protein in the acute phase of hemorrhagic fever with renal syndrome: correlation with disease severity
    Meiliang Wang
    Department of Immunology, Tangdu Hospital, Fourth Military Medical University, Xi an, China
    J Infect Dis 199:188-95. 2009
    The cellular immune response to Hantaan virus (HTNV) is incompletely understood, especially in humans.
  5. pmc Structural studies of Hantaan virus
    Anthony J Battisti
    Department of Biological Sciences, Purdue University, 915 W State Street, West Lafayette, IN 47907 2054, USA
    J Virol 85:835-41. 2011
    b>Hantaan virus is the prototypic member of the Hantavirus genus within the family Bunyaviridae and is a causative agent of the potentially fatal hemorrhagic fever with renal syndrome...
  6. pmc Landscape elements and Hantaan virus-related hemorrhagic fever with renal syndrome, People's Republic of China
    Lei Yan
    State Key Laboratory of Remote Sensing Science, IRSA CAS, Beijing, People s Republic of China
    Emerg Infect Dis 13:1301-6. 2007
    ..information system and remote sensing techniques, was applied to increase our understanding of HFRS due to Hantaan virus and its relationship with landscape elements in China...
  7. pmc Hantavirus causing hemorrhagic fever with renal syndrome enters from the apical surface and requires decay-accelerating factor (DAF/CD55)
    Ellen Krautkrämer
    Department of Nephrology, University of Heidelberg, Im Neuenheimer Feld 162, D 69120 Heidelberg, Germany
    J Virol 82:4257-64. 2008
    ..These results demonstrate that the Old World hantaviruses Hantaan and Puumala enter polarized target cells from the apical site and that DAF is a critical cofactor for infection...
  8. doi Genetic susceptibility to haemorrhagic fever with renal syndrome caused by Hantaan virus in Chinese Han population
    M L Wang
    Department of Immunology, Fourth Military Medical University, 17 Changle West Road, Xi an, China
    Int J Immunogenet 36:227-9. 2009
    ..8%, P = 0.018, OR = 3.76) in patients with haemorrhagic fever with renal syndrome (HFRS) compared to the control group, suggesting Hantaan virus-induced HFRS is associated with a genetic predisposition in the Chinese Han population.
  9. doi Dysregulation of the β3 integrin-VEGFR2 complex in Hantaan virus-directed hyperpermeability upon treatment with VEGF
    Wei Wang
    Center of Infectious Diseases, Tangdu Hospital, The Fourth Military Medical University, Xi an, China
    Arch Virol 157:1051-61. 2012
    ..In this study, we show that VEGF dramatically enhances Hantaan virus (HTNV)-directed permeability and increases the reorganization of the cytoskeleton and the disruption of ..
  10. pmc Identification of three novel CTL epitopes within nucleocapsid protein of Hantaan virus
    Meiliang Wang
    Center for Experimental Medicine, Lanzhou General Hospital, Lanzhou Military Command, Lanzhou, China
    Viral Immunol 24:449-54. 2011
    b>Hantaan virus (HTNV) is a member of the Hantavirus genus that causes human hemorrhagic fever with renal syndrome (HFRS) in humans...
  11. ncbi Hantaan virus enters cells by clathrin-dependent receptor-mediated endocytosis
    Mirim Jin
    Division of Life Science and Graduate School of Biotechnology, Korea University, 1, 5 Ka, Anam Dong, Sungbuk Gu, Seoul 136 701, Korea
    Virology 294:60-9. 2002
    The cellular entry of Hantaan virus (HTN) occurs through interactions with beta(3) integrins as cellular receptors. However, the process of HTN infection following attachment to the cell surface is not well understood...
  12. doi Acute kidney injury in patients with hemorrhagic fever with renal syndrome caused by Hantaan virus: comparative evaluation by RIFLE and AKIN criteria
    Dan Han
    Department of Infectious Diseases, First Affiliated Hospital, School of Medicine, Xi an Jiaotong University, Xi an, Shaanxi Province, People s Republic of China
    Vector Borne Zoonotic Dis 11:723-30. 2011
    ..AKI) is one of the most prominent characteristics of hemorrhagic fever with renal syndrome (HFRS) caused by Hantaan virus. The present study evaluated the incidence and severity of AKI classified by both the RIFLE and AKIN criteria ..
  13. pmc The genetic polymorphisms of HLA are strongly correlated with the disease severity after Hantaan virus infection in the Chinese Han population
    Ying Ma
    Department of Immunology, The Fourth Military Medical University, 169 Changle West Road, Xi an 710032, China
    Clin Dev Immunol 2012:308237. 2012
    ..is a genetic factor that influences the progression of hemorrhagic fever with renal syndrome (HFRS) after Hantaan virus (HTNV) infection, was incompletely understood...
  14. pmc Phase I evaluation of the safety and pharmacokinetics of a single-dose intravenous injection of a murine monoclonal antibody against Hantaan virus in healthy volunteers
    Rong Xu
    Institute of Clinical Pharmacology, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei, People s Republic of China
    Antimicrob Agents Chemother 53:5055-9. 2009
    Anti-Hantaan virus monoclonal antibody (AHM) is a murine monoclonal antibody against Hantaan virus being developed for the treatment of hemorrhagic fever with renal syndrome...
  15. pmc Peptide antagonists that inhibit Sin Nombre virus and hantaan virus entry through the beta3-integrin receptor
    Richard S Larson
    UNM School of Medicine, 2325 Camino de Salud, CRF 223, Albuquerque, NM 87131, USA
    J Virol 79:7319-26. 2005
    ..displayed the greatest potency and had significant sequence similarity) for their abilities to inhibit SNV, Hantaan virus (HTNV), and Prospect Hill virus (PHV) infection...
  16. doi Hantaan virus surveillance targeting small mammals at Dagmar North Training Area, Gyeonggi Province, Republic of Korea, 2001-2005
    Terry A Klein
    Force Health Protection and Preventive Medicine, 65th Medical Brigade U S Army MEDDAC Korea, Unit 15281, APO AP 96205 5281, USA
    J Vector Ecol 36:373-81. 2011
    ..1%), and Microtus fortis (1.1%). Three species of rodents were found to be antibody-positive (Ab+) for Hantaan virus (HTNV): A. agrarius (22.3%), M. musculus (9.1%), and M. fortis (5.0%). Ab+ rates for A...
  17. pmc Alpha/beta interferon (IFN-alpha/beta)-independent induction of IFN-lambda1 (interleukin-29) in response to Hantaan virus infection
    Malin Stoltz
    Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    J Virol 84:9140-8. 2010
    ..Here, we show that in Hantaan virus (HTNV)-infected human epithelial A549 cells, induction of IFN-lambda1 preceded induction of MxA and IFN-beta ..
  18. doi Hantaan virus induces toll-like receptor 4 expression, leading to enhanced production of beta interferon, interleukin-6 and tumor necrosis factor-alpha
    Hong Jiang
    Center of Diagnosis and Treatment for Infectious Diseases, Tangdu Hospital, The Fourth Military Medical University, Xi an, Shaanxi Province, China
    Virology 380:52-9. 2008
    b>Hantaan virus (HTNV) infects endothelial cells and is associated with increased vascular permeability during hemorrhagic fever with renal syndrome (HFRS). The pattern of increased vascular permeability is mediated by immune response...
  19. doi Analysis of the immune response to Hantaan virus nucleocapsid protein C-terminal-specific CD8(+) T cells in patients with hemorrhagic fever with renal syndrome
    Ping Zhong Wang
    Center of Infectious Diseases, Tangdu Hospital, Shaanxi Province, China
    Viral Immunol 22:253-60. 2009
    b>Hantaan virus (HTNV), the prototype member of the Hantavirus genus in the family Bunyaviridae, causes hemorrhagic fever with renal syndrome (HFRS), which is characterized by capillary leakage, hemorrhage, and renal injury, and is an ..
  20. ncbi Quality control measures for the serological diagnosis of hantavirus infections
    Stefan S Biel
    Robert Koch Institut, Nordufer 20, 13353 Berlin, Germany
    J Clin Virol 28:248-56. 2003
    ..Improving the diagnostics of these infections is the most important step in detecting the pathogens and dealing with them, and for this purpose, quality control measures are essential tools...
  21. doi Gold nanoparticle enhanced immuno-PCR for ultrasensitive detection of Hantaan virus nucleocapsid protein
    Longyan Chen
    State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Science, Wuhan, PR China
    J Immunol Methods 346:64-70. 2009
    ..which was modified from the recent developed bio-barcode assay (BCA) technique, was developed to detect Hantaan virus nucleocapsid protein (HNP)...
  22. doi Hantavirus-like particles generated in CHO cells induce specific immune responses in C57BL/6 mice
    Chuan Li
    State Key Laboratory for Molecular Virology and Genetic Engineering, National Institute for Viral Disease Control and Prevention, China CDC 100 Ying Xin Jie, Xuan Wu Qu, Beijing 100052, China
    Vaccine 28:4294-300. 2010
    ..To measure the immunogenicity of Hantaan virus-like particles (HTN-VLPs) vaccine, we generated recombinant HTN-VLPs by co-expressing Hantaan virus ..
  23. pmc The RNA binding domain of the hantaan virus N protein maps to a central, conserved region
    Xiaolin Xu
    Graduate Program in Molecular Biology, Department of Chemistry and Biochemistry, New Mexico State University, Las Cruces, New Mexico 88003, USA
    J Virol 76:3301-8. 2002
    ..To define the domain within the Hantaan virus (HTNV) N protein that mediates these interactions, 14 N- and C-terminal deletion constructs were cloned into a ..
  24. pmc Ribavirin reveals a lethal threshold of allowable mutation frequency for Hantaan virus
    DONG HOON CHUNG
    Department of Biochemistry and Molecular Biology, 2000 9th Avenue South, Southern Research Institute, Birmingham, AL 35205, USA
    J Virol 81:11722-9. 2007
    ..Previously we have shown a lack of correlation between antiviral activity and GTP repression for Hantaan virus (HTNV) and evidence for RBV's ability to promote error-prone replication...
  25. pmc Dynein-dependent transport of the hantaan virus nucleocapsid protein to the endoplasmic reticulum-Golgi intermediate compartment
    Harish N Ramanathan
    Graduate Program in Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Virol 81:8634-47. 2007
    ..Herein, we examine the intracellular trafficking and morphogenesis of the prototype Old World hantavirus, Hantaan virus (HTNV)...
  26. ncbi Expression of interferon inducible genes following Hantaan virus infection as a mechanism of resistance in A549 cells
    Jae Hwan Nam
    Department of Virology, Korean National Institute of Health, Seoul 122 701, Korea
    Virus Genes 26:31-8. 2003
    b>Hantaan virus (HTN) is a causative agent of hemorrhagic fever with renal syndrome (HFRS). Little is known of its pathogenesis or the molecular mechanisms underlying resistance to HTN infection...
  27. ncbi The in vitro and in vivo protective activity of monoclonal antibodies directed against Hantaan virus: potential application for immunotherapy and passive immunization
    Zhikai Xu
    Department of Microbiology, the Fourth Medical University of PLA, Xi an, 710032, People s Republic of China
    Biochem Biophys Res Commun 298:552-8. 2002
    b>Hantaan virus (HTNV), a member of the genus Hantavirus, family Bunyaviridae, is an etiologic agent causing a serious human disease, hemorrhagic fever with renal syndrome (HFRS), with a mortality as high as 15% and is also a potential ..
  28. pmc DNA vaccination with the Hantaan virus M gene protects Hamsters against three of four HFRS hantaviruses and elicits a high-titer neutralizing antibody response in Rhesus monkeys
    J W Hooper
    Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland 21702, USA
    J Virol 75:8469-77. 2001
    Four hantaviruses-Hantaan virus (HTNV), Seoul virus (SEOV), Dobrava virus (DOBV) and Puumala virus-are known to cause hemorrhagic fever with renal syndrome (HFRS) in Europe and Asia...
  29. ncbi The Hantaan virus glycoprotein precursor is cleaved at the conserved pentapeptide WAASA
    C Lober
    Institut fur Virologie, Robert Koch str 17, Marburg, D 35037, Germany
    Virology 289:224-9. 2001
    ..We have demonstrated here the expression of the glycoprotein precursor of Hantaan virus following transfection of mammalian cells...
  30. pmc Ex vivo stability of the rodent-borne Hantaan virus in comparison to that of arthropod-borne members of the Bunyaviridae family
    J Hardestam
    Swedish Institute for Infectious Disease Control, S 171 82 Solna, Sweden
    Appl Environ Microbiol 73:2547-51. 2007
    ..we have compared the stabilities of three viruses within the Bunyaviridae family: the rodent-borne Hantavirus Hantaan virus (HTNV), the sand fly-borne Phlebovirus sandfly fever Sicilian virus (SFSV), and the tick-borne Nairovirus ..
  31. doi Molecular diversity and phylogeny of Hantaan virus in Guizhou, China: evidence for Guizhou as a radiation center of the present Hantaan virus
    Yang Zou
    Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Changping Liuzi 5, 102206 Beijing, PR China
    J Gen Virol 89:1987-97. 2008
    To gain further insight into the molecular epidemiology of Hantaan virus (HTNV) in Guizhou, China, rodents were captured in this region in 2004 and 2005. In addition, serum samples were collected from four patients...
  32. ncbi Analysis of the immune response of Hantaan virus nucleocapsid protein-specific CD8+ T cells in mice
    Midori Taruishi
    Institute for Animal Experimentation, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Sapporo 060 8638, Japan
    Virology 365:292-301. 2007
    The major histocompatibility complex (MHC) class-I restricted epitope of Hantaan virus nucleocapsid protein (N) was identified using overlapping peptides and BALB/c mice...
  33. ncbi Human recombinant neutralizing antibodies against hantaan virus G2 protein
    Joachim Koch
    Hantavirus Forschungsstelle der Heidelberger Akademie der Wissenschaften, Im Neuenheimer Feld 230, D 69120 Heidelberg, Germany
    Virology 308:64-73. 2003
    ..All antibodies bind to Hantaan virus G2 protein localized in the virus envelope...
  34. doi Hantaan virus triggers TLR3-dependent innate immune responses
    Wiebke Handke
    Institute of Virology, Helmut Ruska Haus, University Hospital Charite, Charite Campus Mitte, Berlin, Germany
    J Immunol 182:2849-58. 2009
    ....
  35. ncbi A new model of Hantaan virus persistence in mice: the balance between HTNV infection and CD8(+) T-cell responses
    Koichi Araki
    Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060 0818, Japan
    Virology 322:318-27. 2004
    ..persistence model that involves the adoptive transfer of spleen cells from immunocompetent mice (H-2(d)) into Hantaan virus (HTNV)-infected severe combined immunodeficient (SCID, H-2(d)) mice...
  36. pmc Analysis of N-linked glycosylation of hantaan virus glycoproteins and the role of oligosaccharide side chains in protein folding and intracellular trafficking
    Xiaohong Shi
    Division of Virology, Institute of Biomedical and Life Sciences, University of Glasgow, Church Street, Glasgow G11 5JR, Scotland, United Kingdom
    J Virol 78:5414-22. 2004
    The membrane glycoproteins Gn and Gc of Hantaan virus (HTNV) (family Bunyaviridae) are modified by N-linked glycosylation...
  37. ncbi Modification of endothelial cell functions by Hantaan virus infection: prolonged hyper-permeability induced by TNF-alpha of hantaan virus-infected endothelial cell monolayers
    M Niikura
    Department of Virology 1, National Institute of Infectious Diseases, Musashimurayama, Japan
    Arch Virol 149:1279-92. 2004
    ..In this study, we examined whether Hantaan virus (HTNV) infection modifies the barrier function of endothelial cell monolayers upon the exposure to pro-..
  38. ncbi [The epidemic characteristics and preventive measures of hemorrhagic fever with syndromes in China]
    Yong zhen Zhang
    Institute for Infectious Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China
    Zhonghua Liu Xing Bing Xue Za Zhi 25:466-9. 2004
    ..To summarize and analyze the epidemic situation of hantaviruses including geographic distribution, types and prevalent intensity of epidemic areas of hantavirus for the last 30 years in China, and to discuss relative preventive measures...
  39. pmc Cell fusion activities of Hantaan virus envelope glycoproteins
    Michiko Ogino
    Institute for Animal Experimentation, Graduate School of Medicine, Hokkaido University, Sapporo, Japan
    J Virol 78:10776-82. 2004
    b>Hantaan virus (HTNV)-infected Vero E6 cells undergo cell fusion with both infected and uninfected cells under low-pH conditions...
  40. pmc Essential amino acids of the hantaan virus N protein in its interaction with RNA
    William Severson
    Department of Entomology, Plant Pathology and Weed Science, New Mexico State University, Las Cruces, 88003, USA venue
    J Virol 79:10032-9. 2005
    ..Previously, deletion mapping identified a central, conserved region (amino acids 175 to 217) within the Hantaan virus (HTNV) N protein that interacts with a high affinity with these viral RNAs (vRNAs)...
  41. ncbi Analysis of immune responses against nucleocapsid protein of the Hantaan virus elicited by virus infection or DNA vaccination
    Gyu Jin Woo
    Division of Immunotherapy, Mogam Biotechnology Research Institute, Yongin, Republic of Korea
    J Microbiol 43:537-45. 2005
    Even though neutralizing antibodies against the Hantaan virus (HTNV) has been proven to be critical against viral infections, the cellular immune responses to HTNV are also assumed to be important for viral clearance...
  42. ncbi [Identification of a functional ITAM-like sequence within G1 cytoplasmic tail of Hantaan virus]
    Dan Lei Mou
    Center of Infectious Diseases, Tangdu Hospital, Fourth Military Medical University, Xi an 710038, China
    Bing Du Xue Bao 23:424-8. 2007
    The G1 cytoplasmic tail of Hantaan virus (HTNV) harbors a highly conserved region, which is homologous to immunoreceptor tyrosine-based activation motifs (ITAM) and is termed the ITAM-like sequence...
  43. pmc Activity of ribavirin against Hantaan virus correlates with production of ribavirin-5'-triphosphate, not with inhibition of IMP dehydrogenase
    Yanjie Sun
    Southern Research Institute, 2000 Ninth Avenue South, Birmingham, AL 35205, USA
    Antimicrob Agents Chemother 51:84-8. 2007
    Ribavirin (RBV) is a broad-spectrum antiviral agent that inhibits the production of infectious Hantaan virus (HTNV)...
  44. pmc Hantavirus infection of dendritic cells
    Martin J Raftery
    Institute of Virology, Charite Medical School, Humboldt University Berlin, D 10098 Berlin, Germany
    J Virol 76:10724-33. 2002
    ..Here we show that Hantaan virus (HTNV), which belongs to the Bunyaviridae family (genus Hantavirus) and causes hemorrhagic fever with renal ..
  45. pmc Hantavirus-specific CD8(+)-T-cell responses in newborn mice persistently infected with Hantaan virus
    Koichi Araki
    Laboratory of Public Health, Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060 0818, Japan
    J Virol 77:8408-17. 2003
    ..relationship between virus-specific CD8(+)-T-cell responses and viral persistence was studied in mice by using Hantaan virus (HTNV)...
  46. pmc Ribavirin causes error catastrophe during Hantaan virus replication
    William E Severson
    Department of Chemistry and Biochemistry, New Mexico State University, Las Cruces 88003, USA
    J Virol 77:481-8. 2003
    ..It is well established that ribavirin will inhibit the production of infectious Hantaan virus (HTNV); however, its mechanism of action is unknown...
  47. ncbi Golgi localization of Hantaan virus glycoproteins requires coexpression of G1 and G2
    Xiaohong Shi
    Division of Virology, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow, G11 5JR, Scotland, United Kingdom
    Virology 300:31-8. 2002
    The membrane glycoproteins G1 and G2 of Hantaan virus (HTNV; family Bunyaviridae) are encoded on the M RNA genome segment as a precursor polypeptide that is cotranslationally cleaved by host proteases...
  48. ncbi Generation of an HFRS patient-derived neutralizing recombinant antibody to Hantaan virus G1 protein and definition of the neutralizing domain
    Mifang Liang
    Institute of Virology, Chinese Academy of Preventive Medicine, Beijing, China
    J Med Virol 69:99-107. 2003
    b>Hantaan virus (HTNV) in the Hantavirus genus, family Bunyaviridae, is the major cause of severe hemorrhagic fever with renal syndrome (HFRS)...
  49. ncbi Characterization of HLA-A2.1-restricted epitopes, conserved in both Hantaan and Sin Nombre viruses, in Hantaan virus-infected patients
    Ki Young Lee
    Department of Biotechnology, College of Engineering, Yonsei University, 134 Shinchon dong, Seodaemun gu, Seoul 120 749, South Korea
    J Gen Virol 83:1131-6. 2002
    Nine different CTL epitopes, conserved in both Hantaan virus (HTNV) and Sin Nombre virus (SNV), were selected for study. The binding affinity of each peptide with HLA-A2...
  50. ncbi Increased expression of Hsp70 and co-localization with nuclear protein in cells infected with the Hantaan virus
    L Ye
    Department of Pathology, Fourth Military Medical University, Xi'an 710033, China
    Chin Med J (Engl) 114:535-9. 2001
    OBJECTIVE: To investigate the effect of Hantaan virus infection on the expression of stress genes...
  51. ncbi Dynamic changes of apoptosis-inducing ligands and Th1/Th2 like subpopulations in Hantaan virus-induced hemorrhagic fever with renal syndrome
    Jing Mei Liu
    Department of Immunology, Fourth Military Medical University, Xi an, China
    Clin Immunol 119:245-51. 2006
    ..Both factors may play an important role in the etiology of Hantaan virus infection in humans.
  52. ncbi Clinical and laboratory predictors of oliguric renal failure in haemorrhagic fever with renal syndrome caused by Hantaan virus
    Young Keun Kim
    Department of Internal Medicine, Yonsei University College of Medicine, 134 Shinchon dong, Seodaemun gu, Seoul 120 752, South Korea
    J Infect 54:381-6. 2007
    ..Haemorrhagic fever with renal syndrome (HFRS), caused by hantavirus infection, develops into acute renal failure (ARF) of variable degrees of severity. We investigated the early predictive markers for oliguric ARF in HFRS patients...
  53. ncbi In vivo characterization of the integrin beta3 as a receptor for Hantaan virus cellular entry
    Jin Won Song
    Department of Microbiology and the Institute for Viral Diseases, Division of Brain Korea 21 Program for Biomedical Science, College of Medicine Korea University, Seoul 136 705, Korea
    Exp Mol Med 37:121-7. 2005
    ..In vitro studies suggested that the alpha(v)beta(3) integrin receptor is the epithelial cell receptor for Hantaan virus (HTNV). Whether beta(3) is in vivo the only or central cellular receptor for HTNV infection is not known...
  54. ncbi [Late consequences of hemorrhagic fever with renal syndrome in a woman who had it during pregnancy]
    V A Figurnov
    Klin Med (Mosk) 85:71-2. 2007
    ..Antibodies to Hantaan virus 1:32 were found; magnetic resonance tomography of the skull revealed sequelae of hypophysial hemorrhage with ..
  55. ncbi [Comparative study on antibody levels of vaccination group and control group after 4 years of immunized with type B inactivated vaccine against hemorrhagic fever with renal syndrome]
    Y Ruan
    Center of EPI, Chinese Academy of Preventive Medicine, Beijing 100050, China
    Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi 15:274-6. 2001
    ....
  56. ncbi [A preliminary genetic reassortment between Hantaan virus and Seoul virus strains]
    Wenzhen Kang
    Department of Infectious Diseases, Tangdu Hospital, The Fourth Military Medical University, Xi an 710038, China
    Zhonghua Liu Xing Bing Xue Za Zhi 23:46-9. 2002
    ..To determine the frequency and characteristics of reassortment among Hantaan and Seoul viruses causing hemorrhagic fever with renal syndrome (HFRS)...
  57. ncbi [3 cases of hemorrhagic fever with renal syndrome morbidity]
    A A Nafeev
    Klin Med (Mosk) 86:70-1. 2008
    ....
  58. ncbi Immunization effect of purified bivalent vaccine to haemorrhagic fever with renal syndrome manufactured from primary cultured hamster kidney cells
    Guan mu Dong
    First Division of Viral Vaccine, National Institute for the Control of Phmaceutical and Biological Products, Beijing 100050, China
    Chin Med J (Engl) 118:766-8. 2005
  59. ncbi [Inhibiting effects of fucoidans on Hantaan virus adsorption on a model of peritoneal macrophages in vitro]
    I D Makarenkova
    Vopr Virusol 53:12-5. 2008
    ..of peritoneal macrophages was used to study the effect of fucoidans from brown seaweeds on the adsorption of Hantaan virus. Fucoidans were found to have antiviral activity, but to differ in the inhibition of hantavirus adsorption, ..
  60. ncbi [Epidemiological study of hemorrhagic fever with renal syndrome in 1984-2003 in Weifang City, Shandong Province]
    Fu lian Han
    Shandong Province Weifang City Station for Disease Prevention and Control, Weifang 261041, China
    Zhonghua Liu Xing Bing Xue Za Zhi 25:1096. 2004
  61. ncbi [Using geographic information system to study on the association between epidemic areas and main animal hosts of hemorrhagic fever with renal syndrome in China]
    Li Qun Fang
    Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China
    Zhonghua Liu Xing Bing Xue Za Zhi 25:929-33. 2004
    ..To analyze the association between types of epidemic areas and proportion of main animal hosts of hemorrhagic fever with renal syndrome (HFRS) in China...
  62. ncbi [Preliminary studies on proliferation of hemorrhagic fever with renal syndrome virus in Leptotrombidium (L.) Scutellare]
    Y Zhang
    Nanjing Institute of Military Medicine, Nanjing Command, Nanjing 210002
    Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi 11:259-62. 1997
    ..The isolated HFRSV were amplified by PCR technique and the HFRSV RNA were positive. The above results give rise to evidence that Leptotrombidium (L.) Scutellare might be the transmission vector of HFRSV...
  63. ncbi Variability of G1 gene of hantaviruses occurring in the Hubei Province, P.R. China from 1985 to 2000
    Q Li
    National Key Laboratory of Virology, Institute of Virology, Wuhan University School of Medicine, Wuhan, Hubei 430071, PR China
    Acta Virol 49:51-7. 2005
    ..Our results indicate that temporal factor, represented by years 1985--2000 seems to be too short to affect markedly the genetic makeup of the hantaviruses investigated...
  64. ncbi [Hemorrhagic fever with renal syndrome among servicemen in Primorskiĭ Region of Russia]
    R A Slonova
    Voen Med Zh 326:20-5, 80. 2005
    ..104 HFRS cases were registered in the servicemen. Among them 77.8 +/- 3.0% were at the age of 18-20; 7.4 +/- 2.9% of these cases were lethal...
  65. ncbi Development and evaluation of serological assays for detection of Hantaanvirus-specific antibodies in human sera using yeast-expressed nucleocapsid protein
    Rasa Petraityte
    Institute of Biotechnology, VA Graiciūno 8, LT 02241, Vilnius, Lithuania
    J Virol Methods 148:89-95. 2008
    Indirect and capture enzyme-linked immunosorbent assays (ELISAs) for detection of Hantaan virus (HTNV)-specific immunoglobulins G (IgG) and M (IgM) in human serum samples were developed on the basis of recombinant yeast-expressed ..
  66. ncbi Envelope glycoproteins of hantavirus can mediate cell-cell fusion independently
    Feng Zheng
    Qilu Hospital of Shandong University, Jinan, Shandong Province, China
    New Microbiol 30:101-7. 2007
    ..this report we molecularly cloned viral glycoproteins (GPs) cDNA and nucleocapsid (NP) cDNA of two strains of Hantaan virus and one strain of Seoul virus and expressed in Vero E6 cells under control of a CMV promoter...
  67. ncbi [Occurrence of human hantavirus infections in Poland]
    Małgorzata Sadkowska-Todys
    Zakład Epidemiologii PZH w Warszawie
    Przegl Epidemiol 61:497-503. 2007
    ..These results prove occurrence of hantavirus infections in Poland, however it seems that they are not very prevalent...
  68. pmc Truncated hantavirus nucleocapsid proteins for serotyping Hantaan, Seoul, and Dobrava hantavirus infections
    K Araki
    Laboratory of Public Health, Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060-0818, Japan
    J Clin Microbiol 39:2397-404. 2001
    Truncated recombinant nucleocapsid proteins (rNPs) of Hantaan virus (HTNV), Seoul virus (SEOV), and Dobrava virus (DOBV) were expressed by a baculovirus system...
  69. ncbi [Study on using colloidal gold immuno-dot assay to detect special antibody of hemorrhagic fever renal syndrome]
    F Chu
    Nanhua Hospital, Nanhui County, Shanghai 201300
    Zhongguo Zhong Xi Yi Jie He Za Zhi 21:504-6. 2001
    ..The effect of KHSM combined AD treatment was not significantly different from that of ribarvirin and ganlixin injection...
  70. ncbi Genetic properties of medium (M) and small (S) genomic RNA segments of Seoul hantavirus isolated from Rattus norvegicus and antigenicity analysis of recombinant nucleocapsid protein
    Zexin Tao
    Department of Virology, School of Public Health, Shandong University, The Key Laboratory of Experimental Teratology, Ministry of Education, China, 44 Wenhuaxilu Road, 250012, Jinan, PR China
    Virus Genes 34:23-30. 2007
    ..Sixteen out of seventeen serum samples showed positive for the presence of anti-NP antibodies, indicating that the recombinant NP (rNP) protein of JUN5-14 was a good antigen for detecting hantavirus infection in human...
  71. ncbi [Seroepidemiologic study on hemorrhagic fever with renal syndrome virus in the migration areas of the Three-Gorges Reservoir Chongqing, Region, Yangtze River]
    S Yang
    Department of Epidemiology, Third Military Medical University, Chongqing 400038, China
    Zhonghua Liu Xing Bing Xue Za Zhi 22:284-6. 2001
    ..CONCLUSIONS: This article confirmed that covert infection rate of HFRS in 5 migration areas was not high. The immune level remained low. Hence, it is very necessary to enhance the immunity of the immigrants...
  72. ncbi Truncated recombinant Dobrava hantavirus nucleocapsid proteins induce strong, long-lasting immune responses in mice
    Piet Maes
    Laboratory of Clinical and Epidemiological Virology, Rega Institute for Medical Research, University of Leuven, Leuven, Belgium
    Intervirology 49:253-60. 2006
    ..Our results indicate that the rNp constructs coupled to rP40, represent promising vaccine candidates...
  73. ncbi [Study on the application of geographic information system in spatial distribution of hemorrhage fever with renal syndrome in China]
    Li Qun Fang
    Institute of Microbiology and Epidemiology, Academy of Military Medical Science, Beijing 100071, China
    Zhonghua Liu Xing Bing Xue Za Zhi 24:265-8. 2003
    ..To analyze the spatial distribution of hemorrhagic fever with renal syndrome (HFRS) in China by geographic information system, and to draw up a map on HRFS risk areas...
  74. ncbi [Prevalence of hemorrhagic fever with renal syndrome virus in domestic pigs: an epidemiological investigation in Shandong province]
    Zhan qing Yang
    Department of Epidemiology, Southern Medical University, Guangzhou 510515, China
    Di Yi Jun Yi Da Xue Xue Bao 24:1283-6. 2004
    ..To investigate the epidemiological significance of hemorrhagic fever with renal syndrome virus (HFRSV) infection in domestic pigs in Shandong province, and study the role of domestic pigs in the prevalence of HFRS...
  75. ncbi [Complete genome sequence of 84FLi, a Hantaan virus strain isolated from the liver of fetus aborted by a pregnant women with hemmorrhagic fever with renal syndrome]
    Xinhong Li
    Center for Infectious Diseases of People s Liberation Army Tangdu Hospital Fourth Military Medical University Xi an 710038, China
    Zhonghua Yi Xue Za Zhi 82:981-5. 2002
    To study the complete genome sequence of the Chinese Hantaan virus vaccine strain 84FLi and learn about its molecular characters.
  76. ncbi [Progress in the epidemiologic study of hemorrhagic fever with renal syndrome in China in recent years]
    Guan huang Wu
    Expert Group, Nanjing Military Area, Institute of Military Medicine, Nanjing 210002, China
    Zhonghua Liu Xing Bing Xue Za Zhi 24:413-5. 2003
  77. ncbi Serological study of hantavirus in man in the Autonomous Community of Madrid, Spain
    L Lledo
    Department of Microbiology and Parasitology, Faculty of Medicine, Alcala University, Spain
    J Med Microbiol 51:861-5. 2002
    ..Serological evidence suggests that there is more than one circulating serotype...
  78. pmc Pathogenic and nonpathogenic hantaviruses differentially regulate endothelial cell responses
    Erika Geimonen
    Department of Medicine, Molecular Cell Biology Program, State University of New York, Stony Brook, NY 11794, USA
    Proc Natl Acad Sci U S A 99:13837-42. 2002
    ..cell transcriptional responses directed by hantaviruses associated with HPS [New York-1 virus (NY-1V)], HFRS [Hantaan virus (HTNV)], or by a hantavirus not associated with human disease [Prospect Hill virus (PHV)]...
  79. ncbi [Serological surveillance on vaccine against hemorrhagic fever with renal syndrome]
    Zhen Yu Gong
    Center for Disease Control and Prevention, Zhejiang Province, Hangzhou 310009, China
    Zhonghua Liu Xing Bing Xue Za Zhi 25:400-2. 2004
    ..To observe the serological and epidemiological efficacy of hemorrhagic fever renal syndrome (HFRS) vaccine in Zhejiang province...
  80. ncbi Hantaan virus antibody prevalence in rodent populations of several provinces of northeastern Thailand
    Narong Nitatpattana
    Center for Vaccine Development Research Center for Emerging Viral Disease, Mahidol University, Bangkok, Thailand
    Trop Med Int Health 7:840-5. 2002
    ..3% positive within species), Rattus exulans (2.1%), R. losea (1.6%) and R. rattus (0.9%). Species such as R. exulans and R. losea are candidate hosts of unidentified Hantaan-like viruses in Thailand...
  81. ncbi [Typing of hemorrhagic fever with renal syndrome by cluster analysis]
    Xiu Hua Guo
    Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071, China
    Zhonghua Liu Xing Bing Xue Za Zhi 24:577-80. 2003
    ..To make an inquiry into method of typing of hemorrhagic fever with renal syndrome (HFRS)...
  82. ncbi [Laboratory diagnosis of hemorrhagic fever with renal syndrome in the Ulianovsk region]
    A A Nafeev
    Vopr Virusol 47:47. 2002
    ..The indices of the serologic confirmation of the diagnosis of HFNS are proven to elevate if the optimal intervals of sampling the pair blood sera is observed...
  83. ncbi [Passage adaptability of candidate strains for hemorrhagic fever with renal syndrome purified vaccine in Vero cells and their immunogenicity]
    Wei Chen
    Department of Etiology, Fourth Military Medical University, Xi an 710032, China
    Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi 17:129-32. 2003
    ..To adapt the candidate strains of hemorrhagic fever with renal syndrome (HFRS) purified vaccine to Vero cells and to study their antigenicity and immunogenicity...
  84. ncbi [Molecular analysis of hantavirus isolated from Shandong province]
    Zhi Qiang Wang
    Shandong Hygiene and Anti epidemic Station, Jinan 250014, China
    Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi 17:121-3. 2003
    ..To compare the molecular characteristics of hantaviruses isolated from Shandong province by using PCR typing and nucleotide sequencing...
  85. doi Serum thrombospondin-1 is altered in patients with hemorrhagic fever with renal syndrome
    Zhengwen Liu
    Department of Infectious Diseases, First Affiliated Hospital, School of Medicine, Xi an Jiaotong University, Xi an, Shaanxi, China
    J Med Virol 80:1799-803. 2008
    ....
  86. pmc Use of vesicular stomatitis virus pseudotypes bearing hantaan or seoul virus envelope proteins in a rapid and safe neutralization test
    Michiko Ogino
    Institute for Animal Experimentation, Hokkaido University Graduate School of Medicine, Sapporo 060 8638, Japan
    Clin Diagn Lab Immunol 10:154-60. 2003
    ..The stability of the pseudotype viruses allows distribution of the material to remote areas by using conventional cooling boxes for use as a diagnostic reagent...
  87. ncbi [Experimental study on enzyme dot assay for detection of hemorrhagic fever with renal syndrome antigen]
    Jian Ao Zhang
    Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
    Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi 18:88-90. 2004
    ..To establish a new and efficient method(IEDA) for detection of hemorrhagic fever with renal syndrome virus (HFRSV) antigen...
  88. ncbi [A study on detecting specific antibodies of hemorrhagic fever with renal syndrome and treatment with integrated traditional Chinese and western medicine]
    Feng Chu
    Nanhua Hospital of Nanhui District, Shanghai 201300, China
    Zhong Xi Yi Jie He Xue Bao 2:20-3. 2004
    ....
  89. ncbi [Bunyavirus--virus and host relationship: the coevolution between hantavirus and rodent]
    Hiroaki Kariwa
    Laboratory of Public Health, Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Kita 18, Nishi 9, Kita ku, Sapporo 060 0818, Japan
    Uirusu 52:61-7. 2002
  90. ncbi A system of protein target sequences for anti-RNA-viral chemotherapy by a vitamin B6-derived zinc-chelating trioxa-adamantane-triol
    Andreas J Kesel
    Chammünsterstr 47, D 81827 München, Germany
    Bioorg Med Chem 11:4599-613. 2003
    ..syncytial virus), Filoviridae (Marburg virus, Ebola virus), Bornaviridae (Borna disease virus), Bunyaviridae (Hantaan virus), Arenaviridae (Lassa virus), and Reoviridae (human rotavirus)...
  91. pmc Hantaan virus nucleocapsid protein binds to importin alpha proteins and inhibits tumor necrosis factor alpha-induced activation of nuclear factor kappa B
    Shannon L Taylor
    Science and Technology Division, U S Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland 21702, USA
    J Virol 83:1271-9. 2009
    Hantaviruses such as Hantaan virus (HTNV) and Andes virus cause two human diseases, hemorrhagic fever with renal syndrome and hantavirus pulmonary syndrome, respectively...
  92. ncbi A soluble and heat-resistant form of hantavirus nucleocapsid protein for the serodiagnosis of HFRS
    Sang Myun Park
    Department of Pharmacology and Chronic Inflammatory Disease Research Center, Ajou University School of Medicine, Suwon, Republic of Korea
    J Virol Methods 147:1-9. 2008
    ..into the N-terminal antigenic portion of the nucleocapsid proteins (amino acid residues 1-70) of the Hantaan virus (HTNV-delta N) and Seoul virus (SEOV-delta N)...
  93. pmc Development of serological assays for Thottapalayam virus, an insectivore-borne Hantavirus
    Megumi Okumura
    Institute for Animal Experimentation, Graduate School of Medicine, Hokkaido University, Sapporo 060 8638, Japan
    Clin Vaccine Immunol 14:173-81. 2007
    ..While the isolation of TPMV predates the discovery of the prototype Hantaan virus, little is known about its genetics and biology...
  94. ncbi Prospects for treatment of viral hemorrhagic fevers with ribavirin, a broad-spectrum antiviral drug
    J W Huggins
    Department of Antiviral Studies, U S Army Medical Research Institute of Infectious Diseases, Frederick, Maryland 21701 5011
    Rev Infect Dis 11:S750-61. 1989
    ..death in suckling mice infected with Crimean-Congo hemorrhagic fever virus and in suckling mice infected with Hantaan virus. In the People's Republic of China, ribavirin significantly reduced mortality in patients with hemorrhagic ..
  95. pmc Synthesis of 1-beta-D-ribofuranosyl-3-ethynyl-[1,2,4]triazole and its in vitro and in vivo efficacy against Hantavirus
    DONG HOON CHUNG
    Department of Biochemistry and Molecular Biology, Southern Research Institute, Birmingham, AL 35205, USA
    Antiviral Res 79:19-27. 2008
    ..ETAR showed an EC(50) value of 10 and 4.4 microM for Hantaan virus (HTNV) and Andes virus, respectively...
  96. ncbi [Association of hemorrhagic fever with renal syndrome and HLA-DRB allele polymorphisms in Han nationality, Hubei province]
    Bai Wei
    Department of Gastroenterology, Zhongnan Hospital, Wuhan University, Wuhan 430071, China
    Zhonghua Liu Xing Bing Xue Za Zhi 30:1143-6. 2009
    ..To understand the association of human leukocyte antigen (HLA)-DRB polymorphism and patients diagnosed as hemorrhagic fever with renal syndrome (HFRS)...
  97. ncbi Emergence and persistence of hantaviruses
    S L Klein
    W Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Curr Top Microbiol Immunol 315:217-52. 2007
    ..When Lee and colleagues isolated what is now known as Hantaan virus, the techniques they introduced allowed further investigations into the etiology of the classical hantavirus ..
  98. doi Co-circulation of three pathogenic hantaviruses: Puumala, Dobrava, and Saaremaa in Hungary
    Angelina Plyusnina
    Department of Virology, Infection Biology Research Program, Haartman Institute, University of Helsinki, Helsinki, Finland
    J Med Virol 81:2045-52. 2009
    ..HFRS is caused by Hantaan virus (HTNV), Seoul virus (SEOV), Dobrava virus (DOBV), Saaremaa virus (SAAV), and Puumala virus (PUUV)...
  99. ncbi Detection and typing of human pathogenic hantaviruses by real-time reverse transcription-PCR and pyrosequencing
    Marit Kramski
    Institute of Virology, Helmut Ruska Haus, Charite Campus Mitte, Berlin, Germany
    Clin Chem 53:1899-905. 2007
    ....
  100. ncbi Seroepidemiological study on hantavirus infections in India
    Sara Chandy
    Department of Clinical Virology, Christian Medical College, Dr Ida Scudder Road, Vellore 632004, India
    Trans R Soc Trop Med Hyg 102:70-4. 2008
    ..Western blot using recombinant Hantaan virus nucleocapsid antigen confirmed the presence of anti-hantavirus IgG in 28 (74%) of the 38 sera tested...
  101. ncbi Puumala and Dobrava viruses cause hemorrhagic fever with renal syndrome in Bosnia-Herzegovina: evidence of highly cross-neutralizing antibody responses in early patient sera
    A Lundkvist
    Swedish Institute for Infectious Disease Control, Stockholm
    J Med Virol 53:51-9. 1997
    ..Moreover, although several acute-phase sera showed the highest FRNT titer to Hantaan virus, convalescent sera from these patients in all cases showed high specificity for Puumala or Dobrava viruses...

Research Grants37

  1. Novel Antirivals for Hantavirus Pulmonary Syndrome
    JEFFREY ARTERBURN; Fiscal Year: 2003
    ..The prototype HFRS-hantavirus, Hantaan virus (HTNV), was isolated in 1976 from the lungs of an infected Korean field mouse (Apodemus agrarius)...
  2. Regulation of Antigen Presentation by APLP-2
    Joyce Solheim; Fiscal Year: 2005
    ..presentation of pathogen-derived peptides, including known epitopes from NIAID biodefense priority pathogens (Hantaan virus, Mycobacterium tuberculosis, influenza A, dengue virus, Japanese encephalitis virus, and Listeria ..
  3. Regulation of Antigen Presentation by APLP-2
    CHANTEY MORRIS; Fiscal Year: 2004
    ..MHC class I maturation and presentation of peptides, including known epitopes from NIAID priority pathogens (Hantaan virus, Mycobacterium tuberculosis, influenza A virus, dengue virus, Japanese encephalitis virus, and Listeria ..
  4. Microenvironmental mechanisms of leukemia cell survival
    Richard Larson; Fiscal Year: 2007
    ..In addition, we will share this data with Dr. Tom Look at the Dana Farber Cancer Center in order to correlate his genetic findings in his T-ALL Zebra fish model with our human studies. ..
  5. Multiplex Screening for ABC Transporter Inhibitors
    Richard Larson; Fiscal Year: 2007
    ..The goal of this proposal is to first screen for ABCB1 inhibitors in a developed flow cytometry based assay and then to develop and employ a multiplex assay that can screen for inhibitors of multiple members of the ABC family. ..
  6. Neutralizing Compounds for Viral Hemorrhagic Fever
    Richard Larson; Fiscal Year: 2005
    ....
  7. Cellular and Molecular Mediators of Hantavirus Infection
    Sabra Klein; Fiscal Year: 2006
    ..abstract_text> ..
  8. Neutralizing Compounds for Viral Hemorrhagic Fever
    Richard Larson; Fiscal Year: 2003
    ..abstract_text> ..
  9. Microenvironmental mechanisms of leukemia cell survival
    Richard Larson; Fiscal Year: 2009
    ..In addition, we will share this data with Dr. Tom Look at the Dana Farber Cancer Center in order to correlate his genetic findings in his T-ALL Zebra fish model with our human studies. ..