potyvirus

Summary

Summary: A large genus of plant viruses of the family POTYVIRIDAE which infect mainly plants of the Solanaceae. Transmission is primarily by aphids in a non-persistent manner. The type species is potato virus Y.

Top Publications

  1. ncbi Recessive resistance to plant viruses
    V Truniger
    Centro de Edafología y Biología Aplicada del Segura CEBAS, Consejo Superior de Investigaciones Cientificas CSIC, Apdo Correos 164, 30100 Espinardo Murcia, Spain
    Adv Virus Res 75:119-59. 2009
  2. ncbi Formation of complexes at plasmodesmata for potyvirus intercellular movement is mediated by the viral protein P3N-PIPO
    Taiyun Wei
    Southern Crop Protection and Food Research Centre, Agriculture and Agri Food Canada, London, Ontario, Canada
    PLoS Pathog 6:e1000962. 2010
  3. ncbi Distribution of fitness and virulence effects caused by single-nucleotide substitutions in Tobacco Etch virus
    Purificación Carrasco
    Instituto de Biología Molecular y Celular de Plantas CSIC UPV, Avenida de los Naranjos s n, 46022 Valencia, Spain
    J Virol 81:12979-84. 2007
  4. ncbi Genetic evidence for an essential role for potyvirus CI protein in cell-to-cell movement
    J C Carrington
    Institute of Biological Chemistry, Washington State University, Pullman 99164, USA
    Plant J 14:393-400. 1998
  5. ncbi A cysteine-rich plant protein potentiates Potyvirus movement through an interaction with the virus genome-linked protein VPg
    P Dunoyer
    John Innes Centre, Norwich NR4 7UH, United Kingdom
    J Virol 78:2301-9. 2004
  6. ncbi Point mutations in helper component protease of clover yellow vein virus are associated with the attenuation of RNA-silencing suppression activity and symptom expression in broad bean
    M L M Yambao
    Pathogen Plant Interactions Group, Plant Breeding Science, Graduate School of Agriculture, Hokkaido University, Sapporo, Japan
    Arch Virol 153:105-15. 2008
  7. ncbi Molecular dissection of the potato virus Y VPg virulence factor reveals complex adaptations to the pvr2 resistance allelic series in pepper
    Valérie Ayme
    INRA, UR407 Pathologie Végétale, F 84143 Montfavet, France
    J Gen Virol 88:1594-601. 2007
  8. ncbi Transcriptional changes and oxidative stress associated with the synergistic interaction between Potato virus X and Potato virus Y and their relationship with symptom expression
    Alberto García-Marcos
    Departamento de Biología de Plantas, Centro de Investigaciones Biologicas, CSIC, Ramiro de Maeztu 9, 28040 Madrid, Spain
    Mol Plant Microbe Interact 22:1431-44. 2009
  9. ncbi Spatial analysis of arabidopsis thaliana gene expression in response to Turnip mosaic virus infection
    Chunling Yang
    Department of Plant Pathology, Iowa State University, Ames, Iowa 50011, USA
    Mol Plant Microbe Interact 20:358-70. 2007
  10. ncbi Structural basis for the substrate specificity of tobacco etch virus protease
    Jason Phan
    Macromolecular Crystallography Laboratory, Center for Cancer Research, NCI-Frederick, National Institutes of Health, Frederick, Maryland 21702-1201, USA
    J Biol Chem 277:50564-72. 2002

Research Grants

  1. GENETIC ANALYSIS OF RNA VIRUS-HOST INTERACTION
    JAMES CARRINGTON; Fiscal Year: 2007
  2. EVOLUTION OF IMMUNE RECOGNITION AND EVASION
    Austin Hughes; Fiscal Year: 2006
  3. EVOLUTION OF IMMUNE RECOGNITION AND EVASION
    Austin Hughes; Fiscal Year: 2007
  4. EVOLUTION OF IMMUNE RECOGNITION AND EVASION
    Austin Hughes; Fiscal Year: 2009
  5. GENETICS OF ALZHEIMER'S DISEASE IN ISRAELI ARABS
    ROBERT FRIEDLAND; Fiscal Year: 2009
  6. Symposium on Alzheimer's Disease in the Middle East
    ROBERT FRIEDLAND; Fiscal Year: 2005
  7. Cong Intl. Soc Vascular Behavioral & Cognitive Disorders
    ROBERT FRIEDLAND; Fiscal Year: 2005
  8. EVOLUTION OF IMMUNE RECOGNITION AND EVASION
    Austin Hughes; Fiscal Year: 2002
  9. Symposium on Alzheimer's Disease in the Middle East
    ROBERT FRIEDLAND; Fiscal Year: 2003
  10. International Society for Vascular Behavioral Disorders
    ROBERT FRIEDLAND; Fiscal Year: 2003

Detail Information

Publications220 found, 100 shown here

  1. ncbi Recessive resistance to plant viruses
    V Truniger
    Centro de Edafología y Biología Aplicada del Segura CEBAS, Consejo Superior de Investigaciones Cientificas CSIC, Apdo Correos 164, 30100 Espinardo Murcia, Spain
    Adv Virus Res 75:119-59. 2009
    ..We review actual and probable recessive resistance mechanisms, and bring the chapter to a close by summarizing the current state-of-the-art and offering perspectives on potential future developments...
  2. ncbi Formation of complexes at plasmodesmata for potyvirus intercellular movement is mediated by the viral protein P3N-PIPO
    Taiyun Wei
    Southern Crop Protection and Food Research Centre, Agriculture and Agri Food Canada, London, Ontario, Canada
    PLoS Pathog 6:e1000962. 2010
    ..Previous genetic and ultrastructural data revealed that the potyvirus cyclindrical inclusion (CI) protein is directly involved in cell-to-cell movement, likely through the formation ..
  3. ncbi Distribution of fitness and virulence effects caused by single-nucleotide substitutions in Tobacco Etch virus
    Purificación Carrasco
    Instituto de Biología Molecular y Celular de Plantas CSIC UPV, Avenida de los Naranjos s n, 46022 Valencia, Spain
    J Virol 81:12979-84. 2007
    ..Here we used site-directed mutagenesis to create a collection of 66 clones of Tobacco etch potyvirus, each carrying a different, randomly chosen, single-nucleotide substitution...
  4. ncbi Genetic evidence for an essential role for potyvirus CI protein in cell-to-cell movement
    J C Carrington
    Institute of Biological Chemistry, Washington State University, Pullman 99164, USA
    Plant J 14:393-400. 1998
    The potyvirus cylindrical inclusion (CI) protein, an RNA helicase required for genome replication, was analyzed genetically using alanine-scanning mutagenesis...
  5. ncbi A cysteine-rich plant protein potentiates Potyvirus movement through an interaction with the virus genome-linked protein VPg
    P Dunoyer
    John Innes Centre, Norwich NR4 7UH, United Kingdom
    J Virol 78:2301-9. 2004
    ..The factor, called Potyvirus VPg-interacting protein (PVIP), is a plant-specific protein with homologues in all the species examined, i.e...
  6. ncbi Point mutations in helper component protease of clover yellow vein virus are associated with the attenuation of RNA-silencing suppression activity and symptom expression in broad bean
    M L M Yambao
    Pathogen Plant Interactions Group, Plant Breeding Science, Graduate School of Agriculture, Hokkaido University, Sapporo, Japan
    Arch Virol 153:105-15. 2008
    Helper component protease (HC-Pro) is a potyvirus-encoded multifunctional protein and a major determinant of symptom expression in a susceptible plant...
  7. ncbi Molecular dissection of the potato virus Y VPg virulence factor reveals complex adaptations to the pvr2 resistance allelic series in pepper
    Valérie Ayme
    INRA, UR407 Pathologie Végétale, F 84143 Montfavet, France
    J Gen Virol 88:1594-601. 2007
    ..They provide a better understanding of the variable levels of durability of the resistance conferred by the different pvr2 alleles, and have important consequences for a durable management of the resistances...
  8. ncbi Transcriptional changes and oxidative stress associated with the synergistic interaction between Potato virus X and Potato virus Y and their relationship with symptom expression
    Alberto García-Marcos
    Departamento de Biología de Plantas, Centro de Investigaciones Biologicas, CSIC, Ramiro de Maeztu 9, 28040 Madrid, Spain
    Mol Plant Microbe Interact 22:1431-44. 2009
    ..Interestingly, expression of genes encoding oxylipin biosynthesis was uniquely upregulated by the synergistic infection. Virus-induced gene silencing of alpha-dioxygenase1 delayed cell death during PVX-PVY infection...
  9. ncbi Spatial analysis of arabidopsis thaliana gene expression in response to Turnip mosaic virus infection
    Chunling Yang
    Department of Plant Pathology, Iowa State University, Ames, Iowa 50011, USA
    Mol Plant Microbe Interact 20:358-70. 2007
    ..The functions of these downregulated genes are consistent with viral symptoms, such as chlorosis and stunted growth, providing new insight into mechanisms of pathogenesis...
  10. ncbi Structural basis for the substrate specificity of tobacco etch virus protease
    Jason Phan
    Macromolecular Crystallography Laboratory, Center for Cancer Research, NCI-Frederick, National Institutes of Health, Frederick, Maryland 21702-1201, USA
    J Biol Chem 277:50564-72. 2002
    ..Analysis of the protein-ligand interactions helps to delineate the structural determinants of substrate specificity and provides guidance for reengineering the enzyme to further improve its utility for biotechnological applications...
  11. ncbi Silencing on the spot. Induction and suppression of RNA silencing in the Agrobacterium-mediated transient expression system
    L K Johansen
    Institute of Biological Chemistry, Washington State University, Pullman, Washington 99164-6340, USA
    Plant Physiol 126:930-8. 2001
    ..They also indicate that RNA silencing may be a significant limitation to expression of genes in the Agrobacterium-mediated transient assay but that this limitation can be overcome by using RNA silencing suppressors...
  12. ncbi Natural variation and functional analyses provide evidence for co-evolution between plant eIF4E and potyviral VPg
    Carine Charron
    INRA UR1052, Genetics and Breeding of Fruits and Vegetables, Domaine St Maurice, BP94, F 84143 Montfavet, France
    Plant J 54:56-68. 2008
    ..amino acid changes in the central part of the viral genome-linked protein (VPg) are responsible for the potyvirus's ability to overcome eIF4E-mediated resistance...
  13. ncbi Intrinsic disorder in Viral Proteins Genome-Linked: experimental and predictive analyses
    Eugenie Hebrard
    UMR 1097 Résistance des Plantes aux Bio agresseurs, IRD, CIRAD, Universite de Montpellier II, BP 64501, 34394 Montpellier Cedex 5, France
    Virol J 6:23. 2009
    ..To date, structural data are still limited to small picornaviral VPgs. Recently three phytoviral VPgs were shown to be natively unfolded proteins...
  14. ncbi Discussion paper: The naming of Potato virus Y strains infecting potato
    R P Singh
    Potato Research Centre, Agriculture and Agri Food Canada, New Brunswick, Canada
    Arch Virol 153:1-13. 2008
    ..A more systematic investigation and characterization of PVY from potato at the biological and molecular levels should eventually result in a biologically meaningful genetic strain concept...
  15. ncbi An unusual structure at one end of potato potyvirus particles
    Lesley Torrance
    Scottish Crop Research Institute, Invergowrie, Dundee DD2 5DA, UK
    J Mol Biol 357:1-8. 2006
    ..Our results show that some of the potyvirus particles contain a protruding tip at one end of the virus particles, which is presumably associated with the 5'-..
  16. ncbi HcPro, a multifunctional protein encoded by a plant RNA virus, targets the 20S proteasome and affects its enzymic activities
    Lionel Ballut
    , , 24 avenue des Landais, , France
    J Gen Virol 86:2595-603. 2005
    ..evidence that a plant virus protein, the helper component-proteinase (HcPro) of Lettuce mosaic virus (LMV; genus Potyvirus), interferes with the 20S proteasome ribonuclease is reported here...
  17. ncbi Molecular characterization and detection of recombinant isolates of potato virus Y from China
    Xinxi Hu
    Hunan Provincial Engineering Research Center for Potatoes, College of Horticulture and Landscape, Hunan Agricultural University, Changsha, Hunan 410128, China
    Arch Virol 154:1303-12. 2009
    ..Further analysis of these samples using enzyme-linked immunosorbent assay and bioassay revealed that 'HN2' possesses a PVY(O) serotype, a PVY(N) pathotype in tobacco and a PVY(NTN) pathotype in potato...
  18. ncbi Adaptation of tobacco etch potyvirus to a susceptible ecotype of Arabidopsis thaliana capacitates it for systemic infection of resistant ecotypes
    Jasna Lalić
    Instituto de Biologia Molecular y Celular de Plantas, Consejo Superior de Investigaciones Científicas UPV, 46022 Valencia, Spain
    Philos Trans R Soc Lond B Biol Sci 365:1997-2007. 2010
    ..However, empirical tests of this hypothesis are scarce. Arabiodpsis thaliana--tobacco etch potyvirus (TEV) provides an experimentally suitable pathosystem to explore the interplay between genetic variation in host'..
  19. ncbi Phosphorylation of the potyvirus capsid protein by protein kinase CK2 and its relevance for virus infection
    Konstantin I Ivanov
    Institute of Biotechnology, University of Helsinki, FIN 00014 Helsinki, Finland
    Plant Cell 15:2124-39. 2003
    ..These results suggest that the phosphorylation of PVA CP by CK2 plays an important regulatory role in virus infection...
  20. ncbi Cylindrical inclusion protein of potato virus A is associated with a subpopulation of particles isolated from infected plants
    Rasa Gabrenaite-Verkhovskaya
    Department of Applied Chemistry and Microbiology, FIN 00014 University of Helsinki, Finland
    J Gen Virol 89:829-38. 2008
    ..The results are discussed in the context of a model for CI-mediated functions...
  21. ncbi Application of game theory to the interaction between plant viruses during mixed infections
    Susana Martin
    Instituto de Biología Molecular y Celular de Plantas CSIC UPV, 46022 Valencia, Spain
    J Gen Virol 90:2815-20. 2009
    ..Cauliflower mosaic caulimovirus (CaMV) has often been found in mixed infections with turnip mosaic potyvirus (TuMV) in plants of the genus Brassica...
  22. ncbi The HC-pro protein of potato virus Y interacts with NtMinD of tobacco
    Yongsheng Jin
    State Key Laboratory of Agro Biotechnology, China Aricultural University, Beijing, P R China
    Mol Plant Microbe Interact 20:1505-11. 2007
    ....
  23. ncbi Coordinated and selective recruitment of eIF4E and eIF4G factors for potyvirus infection in Arabidopsis thaliana
    Valerie Nicaise
    Interactions Plante Virus IPV, UMR 1090, INRA Bordeaux 2, BP 81, F 33883 Villenave d Ornon, France
    FEBS Lett 581:1041-6. 2007
    ..analyses of Arabidopsis mutants knocked-out for At-eIF4G genes showed that eIF4G factors are indispensable for potyvirus infection...
  24. ncbi Turnip mosaic virus RNA replication complex vesicles are mobile, align with microfilaments, and are each derived from a single viral genome
    Sophie Cotton
    Department of Plant Science, McGill University, 21, 111 Lakeshore, Ste Anne de Bellevue, Quebec H9X 3V9, Canada
    J Virol 83:10460-71. 2009
    ..A single-genome origin and presence of protein synthetic machinery components suggest that translation of viral RNA is taking place within the vesicle...
  25. ncbi Involvement of the cylindrical inclusion (CI) protein in the overcoming of an eIF4E-mediated resistance against Lettuce mosaic potyvirus
    Anas Abdul-Razzak
    Interactions Plante Virus, UMR GDPP 1090, INRA Université de Bordeaux 2, BP 81, F 33883 Villenave d Ornon, France
    Mol Plant Pathol 10:109-13. 2009
    ..Site-directed mutagenesis pinpointed a key role of the amino acid at position 621 in the virulence. This is the first example of the involvement of a potyviral CI protein in the breaking of an eIF4E-mediated resistance...
  26. ncbi Biochemical and genetic evidence for interactions between potato A potyvirus-encoded proteins P1 and P3 and proteins of the putative replication complex
    A Merits
    Viikki Biocenter, University of Helsinki, Helsinki, FIN 00014, Finland
    Virology 263:15-22. 1999
    Interactions of the first and third proteins (P1 and P3) of the potato A potyvirus (PVA) with the other six main proteins of PVA were studied using Escherichia coli-expressed recombinant proteins in two in vitro interaction assays and a ..
  27. ncbi Mutational analysis of the putative pipo of soybean mosaic virus suggests disruption of PIPO protein impedes movement
    R H Wen
    Department of Entomology and Plant Pathology, The University of Tennessee, Knoxville, TN 37996, USA
    Virology 400:1-7. 2010
    The presence of a small open reading frame embedded in the P3 cistron of potyvirus turnip mosaic virus, termed "pipo," was recently discovered. We have now studied the putative pipo of soybean mosaic virus (SMV)...
  28. ncbi Genomic variability in Potato potyvirus Y (PVY): evidence that PVY(N)W and PVY(NTN) variants are single to multiple recombinants between PVY(O) and PVY(N) isolates
    L Glais
    UMR-BiO3P, INRA, , Rennes-Le Rheu, France
    Arch Virol 147:363-78. 2002
    ..Nevertheless, multiple recombination events observed in the PVY(NTN) genome may play a role in the latter phenomenon...
  29. ncbi Sequential recruitment of the endoplasmic reticulum and chloroplasts for plant potyvirus replication
    Taiyun Wei
    Southern Crop Protection and Food Research Centre, AAFC, 1391 Sandford Street, London, Ontario N5V 4T3, Canada
    J Virol 84:799-809. 2010
    ..that induces the formation of 6K-containing membranous vesicles at endoplasmic reticulum (ER) exit sites for potyvirus genome replication...
  30. ncbi Fluorescent labelling reveals spatial separation of potyvirus populations in mixed infected Nicotiana benthamiana plants
    Christof Dietrich
    Institute of Plant Diseases and Plant Protection, University of Hannover, , 30419 Hannover, Germany
    J Gen Virol 84:2871-6. 2003
    ..Plants infected by any of the PVX/potyvirus combinations exhibited synergistic symptoms and large numbers of cells were doubly infected...
  31. ncbi Functional dissection of naturally occurring amino acid substitutions in eIF4E that confers recessive potyvirus resistance in plants
    Inhwa Yeam
    Department of Plant Breeding and Genetics, College of Agriculture and Life Sciences, Cornell University, Ithaca, NY 14853, USA
    Plant Cell 19:2913-28. 2007
    ..Overexpression of the Capsicum-eIF4E protein containing the G107R amino acid substitution in Solanum lycopersicum indicated that this polymorphism alone is sufficient for the acquisition of resistance against several TEV strains...
  32. ncbi Role of plant virus movement proteins
    Michael Taliansky
    Scottish Crop Research Institute, Invergowrie, Dundee, DD2 5DA, UK
    Methods Mol Biol 451:33-54. 2008
    ..In this review, we focus on the functions and properties of different classes of MPs encoded by RNA containing plant viruses...
  33. ncbi Rapid diagnosis of plant virus diseases by transmission electron microscopy
    Bernd Zechmann
    University of Graz, Institute of Plant Sciences, Schubertstrasse 51, 8010 Graz, Austria
    J Virol Methods 162:163-9. 2009
    ..These methods will contribute towards a rapid and clear identification of virus diseases of plants and will be useful for diagnostic purposes in agriculture and in plant phytopathology...
  34. ncbi The Tobacco etch virus P3 protein forms mobile inclusions via the early secretory pathway and traffics along actin microfilaments
    Xiaoyan Cui
    College of Plant Protection, Northwest A and F University, Yangling, Shaanxi 712100, P R China
    Virology 397:56-63. 2010
    ..Taken together, these data support previous suggestions that P3 may play dual roles in virus movement and replication...
  35. ncbi Amino acid substitutions within the Cys-rich domain of the tobacco etch potyvirus HC-Pro result in loss of transmissibility by aphids
    C Llave
    , , CSIC, Madrid, Spain
    Arch Virol 147:2365-75. 2002
    We examined the role of several amino acid residues located at the N-terminus of the tobacco etch potyvirus (TEV) helper component-proteinase (HC-Pro) in virus transmissibility by aphids...
  36. ncbi Evidence for diversifying selection in Potato virus Y and in the coat protein of other potyviruses
    Benoit Moury
    Station de Pathologie Vegetale, Institut National de la Recherche Agronomique, F 84143 Montfavet cedex, France
    J Gen Virol 83:2563-73. 2002
    ..their biological functions and is essential to an understanding of the evolutionary constraints exerted on the potyvirus genome...
  37. ncbi Helper component-proteinase (HC-Pro) protein of Papaya ringspot virus interacts with papaya calreticulin
    Wentao Shen
    Key Biotechnology Laboratory for Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology ITBB, Chinese Academy of Tropical Agriculture Sciences CATAS, 4 Xueyuan Road, Haikou, 571101, China
    Mol Plant Pathol 11:335-46. 2010
    ....
  38. ncbi Molecular characterisation of an isolate of Dasheen mosaic virus from Zantedeschia aethiopica in China and comparisons in the genus Potyvirus
    J Chen
    College of Life Science, Zhejiang University, Hangzhou, China
    Arch Virol 146:1821-9. 2001
    ..The 9991 nucleotide genome was typical of the genus Potyvirus and phylogenetic analysis showed it to be a member of the Bean common mosaic virus subgroup...
  39. ncbi Interaction between potyvirus P3 and ribulose-1,5-bisphosphate carboxylase/oxygenase (RubisCO) of host plants
    Lin Lin
    State Key Laboratory Breeding Base for Zhejiang Sustainable Pest and Disease Control, Institute of Virology and Biotechnology, Zhejiang Academy of Agricultural Sciences, Hangzhou, 310021, China
    Virus Genes 43:90-2. 2011
    ..It is possible that the potyvirus P3 protein affects the normal functions of RubisCO which thus contributes to symptom development.
  40. ncbi HC-Pro protein of sugar cane mosaic virus interacts specifically with maize ferredoxin-5 in vitro and in planta
    Yu Qin Cheng
    Department of Plant Pathology and State Key Laboratory of Agro Biotechnology, China Agricultural University, Beijing 100094, PR China
    J Gen Virol 89:2046-54. 2008
    ....
  41. ncbi Cellular localisation of calcium ions during potato hypersensitive response to Potato virus Y
    Katarzyna Otulak
    Department of Botany, Faculty of Agriculture and Biology, Warsaw University of Life Sciences SGGW, ul Nowoursynowska 159, 02 776 Warsaw, Poland katarzyna
    Micron 42:381-91. 2011
    ..The precipitates of calcium antimonate were detected near the nuclear envelope, inside karyolymph and along tracheary elements, especially when virus particles were present inside...
  42. ncbi Structural flexibility allows the functional diversity of potyvirus genome-linked protein VPg
    Kimmo I Rantalainen
    Department of Food and Environmental Sciences, University of Helsinki, Finland
    J Virol 85:2449-57. 2011
    ..Taken together, our experimental data support the features presented in the model and the idea that the functional diversity is attributable to structural flexibility...
  43. ncbi Characterisation of Potato virus Y nnp strain inducing veinal necrosis in pepper: a naturally occurring recombinant strain of PVY
    A Fanigliulo
    Dipartimento di Biologia, Difesa e Biotecnologie Agro-Forestali, , Potenza, Italy
    Arch Virol 150:709-20. 2005
    ....
  44. ncbi Complete nucleotide sequence of a potato isolate of strain group C of Potato virus Y from 1938
    Annette M Dullemans
    Plant Research International, Part of Wageningen UR University and Research Centre, Wageningen, The Netherlands
    Arch Virol 156:473-7. 2011
    ..This is the first full-length sequence of a PVY (C) isolate from potato that belongs to the C1 phylogenetic subgroup, which was previously thought to exclusively contain non-potato isolates...
  45. ncbi Molecular resolution of a complex of potyviruses infecting solanaceous crops at the centre of origin in Peru
    C Spetz
    Department of Plant Biology and Forest Genetics, Genetics Centre, SLU, PO Box 7080, SE 750 07 Uppsala, Sweden
    J Gen Virol 84:2565-78. 2003
    ..Many potyviruses (genus Potyvirus) that infect these crops were described 20-30 years ago...
  46. ncbi Stability of Tobacco etch virus infectious clones in plasmid vectors
    Leonor C Bedoya
    Instituto de Biología Molecular y Celular de Plantas CSIC Universidad Politécnica de Valencia, Avenida de los Naranjos, 46022 Valencia, Spain
    Virus Res 149:234-40. 2010
    ..Using the different inocula produced from the three new plasmids the TEV infectivity was also compared. The results showed that agroinoculation is the most effective inoculation method and is where symptoms unfold earlier...
  47. ncbi Characterization of Potato virus Y (PVY) molecular determinants involved in the vein necrosis symptom induced by PVYN isolates in infected Nicotiana tabacum cv. Xanthi
    Michel Tribodet
    INRA/ENSA, , Domaine de la Motte BP 35327, F-35653 Le Rheu Cedex, France
    J Gen Virol 86:2101-5. 2005
    ..Site-directed mutagenesis was used to confirm that these two HC-Pro residues are involved in the TVN phenotype...
  48. ncbi Potyvirus terminal protein VPg, effector of host eukaryotic initiation factor eIF4E
    R Grzela
    Institute of Biochemistry and Biophysics (IBB, Polish Academy of Sciences, Warsaw, Poland
    Biochimie 88:887-96. 2006
    b>Potyvirus RNA contains at the 5' end a covalently linked virus-encoded protein VPg, which is required for virus infectivity...
  49. ncbi Estimation of the number of virus particles transmitted by an insect vector
    Benoit Moury
    Institut National de la Recherche Agronomique, UR407, Pathologie Végétale, F 84143 Montfavet, Cedex, France
    Proc Natl Acad Sci U S A 104:17891-6. 2007
    ..Such narrow bottlenecks emphasize the strength of stochastic events acting on virus populations, and we illustrate, in modeling virus emergence, why estimating this parameter is important...
  50. ncbi The role of the coat protein region in symptom formation on Physalis floridana varies between PVY strains
    Agnes Bukovinszki
    Agricultural Biotechnology Center, Godollo, Hungary
    Virus Res 127:122-5. 2007
    ..The results suggest that symptom determinants may be different even between strains of the same virus species in a particular host...
  51. ncbi Specific differentiation of recombinant PVY(N:O) and PVY(NTN) isolates by multiplex RT-PCR
    Xianzhou Nie
    Potato Research Centre, Agriculture and Agri-Food Canada, P.O. Box 20280, Fredericton, NB, Canada E3B 4Z7
    J Virol Methods 113:69-77. 2003
    ..The cDNA prepared by random primer plus oligo(dT) increased the overall band intensity...
  52. ncbi Evolution of North American PVY(NTN) strain Tu 660 from local PVY(N) by mutation rather than recombination
    Xianzhou Nie
    Potato Research Centre, Agriculture and Agri Food Canada, PO Box 20280, 850 Lincoln Road, Fredericton, New Brunswick, Canada E3B 4Z7
    Virus Genes 26:39-47. 2003
    ..The non-recombinant nature of NA-PVY(NTN) Tu 660 strongly suggests that the recombinant structure of genome is not a necessary prerequisite for the PTNRD phenotype...
  53. ncbi The production of a genus-specific recombinant antibody (scFv) using a recombinant potyvirus protease
    Michael Hust
    Lehrgebiet Molekulargenetik, , , D-30419 Hannover, Germany
    J Virol Methods 106:225-33. 2002
    ..Therefore, the antibody scFv102 has the potential of becoming a general tool to detect potyvirus infections in different plant species.
  54. ncbi Pepper yellow mosaic virus, a new potyvirus in sweetpepper, Capsicum annuum
    A K Inoue-Nagata
    Embrapa Genetic Resources and Biotechnology, Brasilia DF, Brazil
    Arch Virol 147:849-55. 2002
    A potyvirus was found causing yellow mosaic and veinal banding in sweetpepper in Central and Southeast Brazil...
  55. ncbi Evolutionary optimization of peptide substrates for proteases that exhibit rapid hydrolysis kinetics
    Kevin T Boulware
    Department of Chemical Engineering, University of California Santa Barbara, 93106, USA
    Biotechnol Bioeng 106:339-46. 2010
    ....
  56. ncbi Recessive resistance in Pisum sativum and potyvirus pathotype resolved in a gene-for-cistron correspondence between host and virus
    I E Johansen
    Biotechnology Group, Danish Institute of Agricultural Sciences, Thorvaldsensvej 40, DK 1871 Frederiksberg C, Denmark
    J Virol 75:6609-14. 2001
    Pea seed-borne mosaic potyvirus (PSbMV) isolates are divided into pathotypes P-1, P-2, and P-4 according to their infection profile on a panel of Pisum sativum lines. P...
  57. ncbi Biogenesis of cytoplasmic membranous vesicles for plant potyvirus replication occurs at endoplasmic reticulum exit sites in a COPI- and COPII-dependent manner
    Taiyun Wei
    Southern Crop Protection and Food Research Centre, AAFC, 1391 Sandford Street, London, Ontario N5V 4T3, Canada
    J Virol 82:12252-64. 2008
    ..Previously, a 6-kDa potyvirus membrane protein (6K) was shown to interact with the endoplasmic reticulum (ER) and to induce the formation of ..
  58. ncbi Cap-independent translation conferred by the 5' leader of tobacco etch virus is eukaryotic initiation factor 4G dependent
    D R Gallie
    Department of Biochemistry, University of California, Riverside, California 92521 0129, USA
    J Virol 75:12141-52. 2001
    ..TEV IRES activity was enhanced moderately by the poly(A)-binding protein. These observations suggest that the TEV IRES directs cap-independent translation through a mechanism that involves eIF4G specifically...
  59. ncbi Covalent immobilization of tobacco-etch-virus NIa protease: a useful tool for cleavage of the histidine tag of recombinant proteins
    Ana Cristina Puhl
    Centro de Biologia Molecular Estrutural, Departamento de Bioquimica, Universidade Federal de Santa Catarina, 88040 900 Florianopolis, SC, Brazil
    Biotechnol Appl Biochem 53:165-74. 2009
    ....
  60. ncbi Potyvirus genome-linked protein (VPg) determines pea seed-borne mosaic virus pathotype-specific virulence in Pisum sativum
    K E Keller
    USDA ARS, Horticultural Crops Research Laboratory, Oregon State University, Corvallis 97330, USA
    Mol Plant Microbe Interact 11:124-30. 1998
    The mechanism of Pisum sativum pathotype-specific resistance to pea seed-borne mosaic potyvirus (PSbMV) was investigated and the coding region determinant of PSbMV virulence was defined...
  61. ncbi Simultaneous equimolar expression of multiple proteins in plants from a disarmed potyvirus vector
    Leonor Bedoya
    Instituto de Biologia Molecular y Celular de Plantas, Consejo Superior de Investigaciones Cientificas Universidad Politecnica de Valencia, Avenida de los Naranjos, 46022 Valencia, Spain
    J Biotechnol 150:268-75. 2010
    ..The technology is based on the replacement of the viral RNA polymerase (NIb) cistron of a potyvirus by a cassette for the coexpression of multiple heterologous proteins...
  62. ncbi A novel recombinant strain of Potato virus Y suggests a new viral genetic determinant of vein necrosis in tobacco
    Xiaojun Hu
    University of Idaho, Department of PSES, Moscow, ID 83844, United States
    Virus Res 143:68-76. 2009
    ..Taken together, these data suggest that the vein necrosis genetic determinant of PVY in tobacco is complex and includes other element(s), in addition to the C-terminal fragment of HC-Pro...
  63. ncbi Engineering zucchini yellow mosaic potyvirus as a non-pathogenic vector for expression of heterologous proteins in cucurbits
    T Arazi
    ViroGene Limited, Har-Hotzvim, P.O. Box 45010, 91045, Jerusalem, Israel
    J Biotechnol 87:67-82. 2001
    ..A novel attenuated zucchini yellow mosaic potyvirus (AG) was used for the development of an environmentally safe non-pathogenic virus vector...
  64. ncbi The I gene of bean: a dosage-dependent allele conferring extreme resistance, hypersensitive resistance, or spreading vascular necrosis in response to the potyvirus Bean common mosaic virus
    C W Collmer
    Department of Biological and Chemical Sciences, Wells College, Aurora, NY 13026, USA
    Mol Plant Microbe Interact 13:1266-70. 2000
    The resistance to the potyvirus Bean common mosaic virus (BCMV) conferred by the I allele in cultivars of Phaseolus vulgaris has been characterized as dominant, and it has been associated with both immunity and a systemic vascular ..
  65. ncbi Kinetic mechanism for the binding of eIF4F and tobacco Etch virus internal ribosome entry site rna: effects of eIF4B and poly(A)-binding protein
    Mateen A Khan
    Department of Chemistry and Biochemistry, Hunter College and Graduate Center of the City University of New York, New York, New York 10065, USA
    J Biol Chem 284:35461-70. 2009
    ..Poly(A)-binding protein and eIF4B mainly affect the eIF4F/TEV association rate. These results demonstrate the first direct kinetic measurements of translation initiation factor binding to an IRES...
  66. ncbi From hypo- to hypersuppression: effect of amino acid substitutions on the RNA-silencing suppressor activity of the Tobacco etch potyvirus HC-Pro
    Clara Torres-Barceló
    Instituto de Biologia Molecular y Celular de Plantas, Consejo Superior de Investigaciones Científicas UPV, 46022 Valencia, Spain
    Genetics 180:1039-49. 2008
    ..Tobacco etch potyvirus (TEV) HC-Pro protein suppresses RNA silencing and participates in aphid-mediated transmission, polyprotein ..
  67. ncbi A new approach for the simultaneous differentiation of biological and geographical strains of Potato virus Y by uniplex and multiplex RT-PCR
    Xianzhou Nie
    Potato Research Centre, Agriculture and Agri-Food Canada, P.O. Box 20280, Fredericton, NB, Canada E3B 4Z7
    J Virol Methods 104:41-54. 2002
    ..Primer pairs can be used in a uniplex (single pair of primer) or multiplex (duplex, tetraplex or pentaplex) competitive RT-PCR, allowing simultaneous testing for any combination of PVY(O), EU-PVY(N/NTN), NA-PVY(N) and NA-PVY(NTN)...
  68. ncbi Probable geographical grouping of PVY(N) and PVY(NTN) based on sequence variation in P1 and 5'-UTR of PVY genome and methods for differentiating North American PVY(NTN)
    Xianzhou Nie
    Potato Research Centre, Agriculture and Agri-Food Canada, Fredericton, Canada
    J Virol Methods 103:145-56. 2002
    ..Thus sequencing of the P1 gene and use of competitive RT-PCR approach could be applicable for determining the possible origin of new occurrences of PVY(NTN) from other geographical regions...
  69. ncbi Mapping tightly linked genes controlling potyvirus infection at the Rsv1 and Rpv1 region in soybean
    M A Gore
    Department of Crop and Soil Environmental Sciences, Virginia Polytechnic Institute and State University, Blacksburg 24061, USA
    Genome 45:592-9. 2002
    ..Isolating and characterizing Rsv1 and Rpv1 are instrumental in providing insight into the molecular mechanism of potyvirus recognition in soybean...
  70. ncbi Processive degradation of nascent polypeptides, triggered by tandem AGA codons, limits the accumulation of recombinant tobacco etch virus protease in Escherichia coli BL21(DE3)
    Rachel B Kapust
    Protein Engineering Section, National Cancer Institute at Frederick, Frederick, Maryland 21702-1201, USA
    Protein Expr Purif 24:61-70. 2002
    ....
  71. ncbi Characterisation of a potyvirus and a potexvirus from Chinese scallion
    J Che
    Department of Biotechnology, College of Life Sciences, Zhejiang University, Hangzhou, People s Republic of China
    Arch Virol 147:683-93. 2002
    ..The complete sequences of a potyvirus and a potexvirus were determined and these were shown to represent different viruses from any in the databases...
  72. ncbi Mutational analysis of plant cap-binding protein eIF4E reveals key amino acids involved in biochemical functions and potyvirus infection
    Sylvie German-Retana
    Interactions Plante Virus, UMR GDPP 1090, INRA Université de Bordeaux 2, BP 81, F 33883 Villenave d Ornon Cedex, France
    J Virol 82:7601-12. 2008
    ..In addition to providing a functional mutational map of a plant eIF4E, this suggests that the role of eIF4E in the LMV cycle might be distinct from its physiological function in cellular mRNA translation...
  73. ncbi Characterization of a new potyvirus infecting pepper crops in Ecuador
    Berenger Janzac
    Institut National de la Recherche Agronomique, UR 407 Pathologie Végétale, domaine St Maurice BP 94, Montfavet, France
    Arch Virol 153:1543-8. 2008
    Sequencing 2,951 nucleotides of the 3' proximal region of the genome of a potyvirus isolate collected from Capsicum pubescens (rocoto) pepper in Ecuador revealed that this was the first representative of a new species tentatively named ..
  74. ncbi Potato virus A genome-linked protein VPg is an intrinsically disordered molten globule-like protein with a hydrophobic core
    Kimmo I Rantalainen
    Department of Applied Chemistry and Microbiology, PO Box 27, FIN 00014, University of Helsinki, Finland
    Virology 377:280-8. 2008
    Genome-linked protein VPg of Potato virus A (PVA; genus Potyvirus) has essential functions in all critical steps of PVA infection, i.e. replication, movement, and virulence...
  75. ncbi Helper component proteinase of the genus Potyvirus is an interaction partner of translation initiation factors eIF(iso)4E and eIF4E and contains a 4E binding motif
    Marjo Ala-Poikela
    Department of Agricultural Sciences, P O Box 27, FI 00014, University of Helsinki, Finland
    J Virol 85:6784-94. 2011
    The multifunctional helper component proteinase (HCpro) of potyviruses (genus Potyvirus; Potyviridae) shows self-interaction and interacts with other potyviral and host plant proteins...
  76. ncbi Double mutations in eIF4E and eIFiso4E confer recessive resistance to Chilli veinal mottle virus in pepper
    Jeena Hwang
    Department of Plant Science, Plant Genomics and Breeding Institute, and Research Institute of Agriculture and Life Sciences, Seoul National University, Seoul 151 921, Korea
    Mol Cells 27:329-36. 2009
    ..These results demonstrated that ChiVMV can use both eIF4E and eIFiso4E for replication, making simultaneous mutations in eIF4E and eIFiso4E necessary to prevent ChiVMV infection in pepper...
  77. ncbi Evidence for RNA-mediated defence effects on the accumulation of Potato leafroll virus
    H Barker
    Scottish Crop Research Institute, Invergowrie, Dundee DD2 5DA, UK
    J Gen Virol 82:3099-106. 2001
    ..by producing tobacco plants in which cells contained both PLRV cDNA and DNA encoding the P1/HC-Pro genes of the potyvirus Tobacco etch virus...
  78. ncbi Characterization of a new potyvirus isolated from Chinese artichoke in Japan
    S Fuji
    Faculty of Bioresource Sciences, Akita Prefectural University, Shimoshinjo, Akita, Japan
    Arch Virol 148:2249-55. 2003
    ..This virus was assigned to the genus Potyvirus, based on particle morphology and serological properties...
  79. ncbi The determinant of potyvirus ability to overcome the RTM resistance of Arabidopsis thaliana maps to the N-terminal region of the coat protein
    V Decroocq
    UMR GDPP, INRA Université Bordeaux II, IBVM, Centre INRA de Bordeaux, BP 81, 33883 Villenave d Ornon Cedex France
    Mol Plant Microbe Interact 22:1302-11. 2009
    ..Taken together, these findings demonstrate that the potyvirus CP N-terminal region determines the outcome of the interaction with the RTM-mediated resistance.
  80. ncbi Structural analysis of the eukaryotic initiation factor 4E gene controlling potyvirus resistance in pepper: exploitation of a BAC library
    Sandrine Ruffel
    INRA, Plant Genomics Research Unit, 2 rue G. Cremieux, CP 5708, F-91057 Evry Cedex, France
    Gene 338:209-16. 2004
    ..a eukaryotic translation initiation factor 4E (eIF4E) gene that confers resistance to viruses belonging to the potyvirus genus...
  81. ncbi Suppressor activity of potyviral and cucumoviral infections in potyvirus-induced transgene silencing
    Carmen Simón-Mateo
    Centro Nacional de Biotecnología C S I C, Campus de la Universidad Autonoma de Madrid, 28049 Madrid, Spain
    J Gen Virol 84:2877-83. 2003
    ..Surprisingly, only the silencing suppression caused by CMV, but not that originating from TVMV, was able to revert the recovered NIbV3 plants to a PPV-susceptible phenotype...
  82. ncbi Strain-specific interaction of the tobacco etch virus NIa protein with the translation initiation factor eIF4E in the yeast two-hybrid system
    M C Schaad
    Institute of Biological Chemistry, Washington State University, Pullman, Washington 99164 6340, USA
    Virology 273:300-6. 2000
    ..In TEV-eIF4E coexpression experiments, evidence suggesting that eIF4E provides a positive effect on genome amplification was obtained...
  83. ncbi The eukaryotic translation initiation factor 4E controls lettuce susceptibility to the Potyvirus Lettuce mosaic virus
    Valerie Nicaise
    Interactions Plante Virus, Institut de Biologie Végétale Moléculaire, Institut National de la Recherche Agronomique, boite postale 81, F 33883 Villenave d Ornon Cedex, France
    Plant Physiol 132:1272-82. 2003
    ..Lactuca sativa) that are susceptible, tolerant, or resistant to infection by Lettuce mosaic virus (LMV; genus Potyvirus) were cloned and sequenced...
  84. ncbi Comparison of the substrate specificity of two potyvirus proteases
    Jozsef Tozser
    Department of Biochemistry and Molecular Biology, Research Center for Molecular Medicine, University of Debrecen, Debrecen, Hungary
    FEBS J 272:514-23. 2005
    ..Additional residues in the substrate-binding subsites of TEV protease were also mutated in an effort to alter the specificity of the enzyme...
  85. ncbi Characterisation of an isolate of Narcissus degeneration virus from Chinese narcissus (Narcissus tazetta var. chinensis)
    J Chen
    Institute of Virology and Biotechnology, Zhejiang Academy of Agricultural Sciences, Hangzhou, PR China
    Arch Virol 152:441-8. 2007
    A potyvirus from Chinese narcissus was transmitted mechanically to three species of Narcissus and to Lycoris radiata but not to 22 other test species...
  86. ncbi Salicylic acid-mediated and RNA-silencing defense mechanisms cooperate in the restriction of systemic spread of plum pox virus in tobacco
    Josefa M Alamillo
    Department of Plant Molecular Genetics, , , 28049 Madrid, Spain
    Plant J 48:217-27. 2006
    ..Both an RNA-silencing and an SA-mediated defense mechanism could act together to limit PPV infection...
  87. ncbi Three heterologous proteins simultaneously expressed from a chimeric potyvirus: infectivity, stability and the correlation of genome and virion lengths
    Jani Kelloniemi
    Department of Applied Biology, P O Box 27, FIN 00014 University of Helsinki, Finland
    Virus Res 135:282-91. 2008
    Three heterologous proteins were simultaneously expressed from a chimeric potyvirus Potato virus A (PVA) in Nicotiana benthamiana...
  88. ncbi A new potyvirus from tuberose ( Polianthes tuberosa) in China
    L Lin
    Department of Virology and Biotechnology, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, People s Republic of China
    Arch Virol 149:1107-16. 2004
    ..mottle symptoms, growing in a glasshouse in Hangzhou, China, contained virions and inclusion bodies typical of a potyvirus. The virus was mechanically transmitted to tuberose but not to 14 other test plant species...
  89. ncbi The genomic sequence of Wisteria vein mosaic virus and its similarities with other potyviruses
    W X Liang
    Department of Plant Pathology and State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing, PR China
    Arch Virol 151:2311-9. 2006
    ..acid sequences support the current status of Wisteria vein mosaic virus (WVMV) as a distinct virus of the genus Potyvirus and a member of the Bean common mosaic virus (BCMV) subgroup...
  90. ncbi Complete nucleotide sequence of the genomic RNA of Narcissus yellow stripe virus from Chinese narcissus in Zhangzhou city, China
    J Chen
    Institute of Virology and Biotechnology, Zhejiang Academy of Agricultural Sciences, Hangzhou, PR China
    Arch Virol 151:1673-7. 2006
  91. ncbi Rapid identification of potato virus Y strains by one-step triplex RT-PCR
    Stefania Rigotti
    Agroscope Changins Wädenswil Research Station ACW, Department of Virology, CH 1260 Nyon 1, Switzerland
    J Virol Methods 140:90-4. 2007
    ..The one-step triplex RT-PCR described here fastens specific detection of PVY strains that are otherwise only distinguishable by combined serological and biological assays...
  92. ncbi Vanilla mosaic virus isolates from French Polynesia and the Cook Islands are Dasheen mosaic virus strains that exclusively infect vanilla
    K Farreyrol
    School of Biological Sciences, The University of Auckland, Auckland, New Zealand
    Arch Virol 151:905-19. 2006
    ..In accordance with current ICTV criteria for species demarcation within the family Potyviridae, VanMV-CI and VanMV-FP are strains of DsMV that exclusively infect vanilla...
  93. ncbi Whole genome characterization of Potato virus Y isolates collected in the western USA and their comparison to isolates from Europe and Canada
    J H Lorenzen
    PSES Department, University of Idaho, Moscow, Idaho 83844, USA
    Arch Virol 151:1055-74. 2006
    ....
  94. ncbi Cowpea aphid-borne mosaic virus (CABMV) is widespread in passionfruit in Brazil and causes passionfruit woodiness disease
    A V S Nascimento
    Departamento de Fitopatologia/BIOAGRO, , , Brazil
    Arch Virol 151:1797-809. 2006
    ..Together, these results provide unequivocal evidence that, in Brazil, passionfruit woodiness disease is primarily caused by CABMV. The presence of PWV in Brazil has yet to be confirmed...
  95. ncbi Konjak mosaic virus: the complete nucleotide sequence of the genomic RNA and its comparison with other potyviruses
    M Nishiguchi
    National Institute of Agrobiological Sciences, Tsukuba, Japan
    Arch Virol 151:1643-50. 2006
    Konjak mosaic virus (KoMV) belongs to the genus Potyvirus, family Potyviridae. The complete nucleotide sequence of KoMV F isolate (KoMV F) was determined...
  96. ncbi Molecular variability of the coat protein gene of Potato virus Y from tobacco in China
    N Li
    State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing
    Acta Virol 50:107-13. 2006
    ..6%. The highest identity was observed in the C-terminal half of the CP protein, where only 11 amino acid differences could be observed, in contrast to the N-terminal half with 22 differences...
  97. ncbi Molecular characterization of Czech and Chinese leek yellow stripe virus isolates from garlic
    M Navratil
    Faculty of Sciences, Palack y University, 783 71 Olomouc, Czech Republic
    Acta Virol 50:207-10. 2006
    ..The RT-PCR products were cloned and sequenced. Phylogenetic analysis based on deduced amino acid sequence of NIb-CP region placed the Czech isolates in the group I and the Chinese isolate in the group II of LYSV...
  98. ncbi Complete genome sequence of an isolate of Papaya ringspot virus from India
    B Parameswari
    Unit of Plant Virology, Division of Plant Pathology, Indian Agricultural Research Institute, New Delhi, India
    Arch Virol 152:843-5. 2007
  99. ncbi A new potyvirus from butterfly flower (Iris japonica Thunb.) in Zhejiang, China
    J Chen
    Faculty of Life Science and Biotechnology, Ningbo University, Ningbo, 315211, Zhejiang Province, People s Republic of China
    Arch Virol 153:567-9. 2008
    ..Sequencing of the 3'-terminus of the genome showed that it was a potyvirus, most closely related to sunflower mosaic virus (63...
  100. ncbi Genetic structure of a population of Potato virus Y inducing potato tuber necrotic ringspot disease in Japan; comparison with North American and European populations
    Tetsuji Ogawa
    Aino Potato Branch, Nagasaki Agriculture and Forestry Experiment Station, Nagasaki 854 0302, Japan
    Virus Res 131:199-212. 2008
    ..Our results suggest that PVY PTNRD was recently introduced into Japan more than once, and has expanded throughout Japan from founder populations...
  101. ncbi Biological characterization and complete nucleotide sequence of a Tunisian isolate of Moroccan watermelon mosaic virus
    S Yakoubi
    Laboratoire de Genetique Moleculaire, Immunologie et Biotechnologie, Faculte des Sciences, Tunis, Tunisia
    Arch Virol 153:117-25. 2008
    ..DAS-ELISA showed the presence of Moroccan watermelon mosaic virus (MWMV, Potyvirus), detected for the first time in Tunisia, in samples from the region of Cap Bon (Northern Tunisia)...

Research Grants26

  1. GENETIC ANALYSIS OF RNA VIRUS-HOST INTERACTION
    JAMES CARRINGTON; Fiscal Year: 2007
    ..model host to address the functions of two cellular compatibility factors that were identified in screens for potyvirus susceptibility mutants...
  2. EVOLUTION OF IMMUNE RECOGNITION AND EVASION
    Austin Hughes; Fiscal Year: 2006
    ..abstract_text> ..
  3. EVOLUTION OF IMMUNE RECOGNITION AND EVASION
    Austin Hughes; Fiscal Year: 2007
    ..In addition, by increasing our understanding of the population diversity and evolutionary history of human immune system genes, this research will enhance our knowledge of human immune function in health and disease. ..
  4. EVOLUTION OF IMMUNE RECOGNITION AND EVASION
    Austin Hughes; Fiscal Year: 2009
    ..In addition, by increasing our understanding of the population diversity and evolutionary history of human immune system genes, this research will enhance our knowledge of human immune function in health and disease. ..
  5. GENETICS OF ALZHEIMER'S DISEASE IN ISRAELI ARABS
    ROBERT FRIEDLAND; Fiscal Year: 2009
    ..The ultimate goal of this study is to find new targets (genetic and non-genetic) for therapy. ..
  6. Symposium on Alzheimer's Disease in the Middle East
    ROBERT FRIEDLAND; Fiscal Year: 2005
    ..Topics to be covered include dementia, basic science, diagnoses, history, management and treatment, and ethics, with consideration of the unique cultural traditions of Arab and Jewish populations. ..
  7. Cong Intl. Soc Vascular Behavioral & Cognitive Disorders
    ROBERT FRIEDLAND; Fiscal Year: 2005
    ..Our second event will present in one large Congress the most recent advances in the field, including diagnostic and therapeutic developments by internationally recognized opinion leaders. ..
  8. EVOLUTION OF IMMUNE RECOGNITION AND EVASION
    Austin Hughes; Fiscal Year: 2002
    ....
  9. Symposium on Alzheimer's Disease in the Middle East
    ROBERT FRIEDLAND; Fiscal Year: 2003
    ..Topics to be covered include dementia, basic science, diagnoses, history, management and treatment, and ethics, with consideration of the unique cultural traditions of Arab and Jewish populations. ..
  10. International Society for Vascular Behavioral Disorders
    ROBERT FRIEDLAND; Fiscal Year: 2003
    ..This meeting will present in one large Congress the most recent advances in the field, including diagnostic and therapeutic developments by internationally recognized opinion leaders. ..
  11. Gene Duplication and Genome Evolution
    Austin Hughes; Fiscal Year: 2004
    ..5) Examining the role of transposable elements in duplication of genomic segments by testing for nonrandom association between these elements and putatively duplicated blocks in the yeast genome. ..
  12. EVOLUTION OF IMMUNE RECOGNITION AND EVASION
    Austin L Hughes; Fiscal Year: 2010
    ..In addition, by increasing our understanding of the population diversity and evolutionary history of human immune system genes, this research will enhance our knowledge of human immune function in health and disease. ..