poxviridae

Summary

Summary: A family of double-stranded DNA viruses infecting mammals (including humans), birds and insects. There are two subfamilies: CHORDOPOXVIRINAE, poxviruses of vertebrates, and ENTOMOPOXVIRINAE, poxviruses of insects.

Top Publications

  1. ncbi Poxviruses and immune evasion
    Bruce T Seet
    Department of Microbiology and Immunology, University of Western Ontario, London, Canada
    Annu Rev Immunol 21:377-423. 2003
  2. pmc Poxvirus-encoded gamma interferon binding protein dampens the host immune response to infection
    Isaac G Sakala
    The John Curtin School of Medical Research, Australian National University, Acton, ACT 0200, Australia
    J Virol 81:3346-53. 2007
  3. ncbi Targeted and armed oncolytic poxviruses: a novel multi-mechanistic therapeutic class for cancer
    David H Kirn
    Jennerex Biotherapeutics Inc, San Francisco, California 94105, USA
    Nat Rev Cancer 9:64-71. 2009
  4. pmc Eukaryotic large nucleo-cytoplasmic DNA viruses: clusters of orthologous genes and reconstruction of viral genome evolution
    Natalya Yutin
    National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA
    Virol J 6:223. 2009
  5. ncbi Poxvirus host cell entry
    Florian Ingo Schmidt
    Institute of Biochemistry, ETH Zurich, Schafmattstr 18, 8093 Zurich, Switzerland
    Curr Opin Virol 2:20-7. 2012
  6. pmc Rational strain selection and engineering creates a broad-spectrum, systemically effective oncolytic poxvirus, JX-963
    Steve H Thorne
    Department of Pediatrics and Bio X Program, James H Clark Center, Stanford University School of Medicine, Stanford, California, USA
    J Clin Invest 117:3350-8. 2007
  7. pmc Poxvirus multiprotein entry-fusion complex
    Tatiana G Senkevich
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 0445, USA
    Proc Natl Acad Sci U S A 102:18572-7. 2005
  8. pmc TRAIL gene-armed oncolytic poxvirus and oxaliplatin can work synergistically against colorectal cancer
    M F Ziauddin
    Department of Surgery, University of Pittsburgh School of Medicine and University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA
    Gene Ther 17:550-9. 2010
  9. pmc Poxvirus protein evolution: family wide assessment of possible horizontal gene transfer events
    Mary R Odom
    Department of Microbiology, University of Alabama Birmingham, Birmingham, AL 35294 2170, USA
    Virus Res 144:233-49. 2009
  10. ncbi The poxvirus vectors MVA and NYVAC as gene delivery systems for vaccination against infectious diseases and cancer
    Carmen E Gomez
    Department of Molecular and Cellular Biology, Centro Nacional de Biotecnologia, CSIC, Ciudad Universitaria Cantoblanco, 28049, Madrid, Spain
    Curr Gene Ther 8:97-120. 2008

Detail Information

Publications206 found, 100 shown here

  1. ncbi Poxviruses and immune evasion
    Bruce T Seet
    Department of Microbiology and Immunology, University of Western Ontario, London, Canada
    Annu Rev Immunol 21:377-423. 2003
    ..Furthermore, because of their anti-inflammatory nature, many of these poxvirus proteins hold promise as potential therapeutic agents for acute or chronic inflammatory conditions...
  2. pmc Poxvirus-encoded gamma interferon binding protein dampens the host immune response to infection
    Isaac G Sakala
    The John Curtin School of Medical Research, Australian National University, Acton, ACT 0200, Australia
    J Virol 81:3346-53. 2007
    ....
  3. ncbi Targeted and armed oncolytic poxviruses: a novel multi-mechanistic therapeutic class for cancer
    David H Kirn
    Jennerex Biotherapeutics Inc, San Francisco, California 94105, USA
    Nat Rev Cancer 9:64-71. 2009
    ..Initial preclinical and clinical results show that products from this therapeutic class can systemically target cancers in a highly selective and potent fashion using a multi-pronged mechanism of action...
  4. pmc Eukaryotic large nucleo-cytoplasmic DNA viruses: clusters of orthologous genes and reconstruction of viral genome evolution
    Natalya Yutin
    National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA
    Virol J 6:223. 2009
    ....
  5. ncbi Poxvirus host cell entry
    Florian Ingo Schmidt
    Institute of Biochemistry, ETH Zurich, Schafmattstr 18, 8093 Zurich, Switzerland
    Curr Opin Virol 2:20-7. 2012
    ..This review highlights recent advances in the understanding of poxvirus MV and EV cell entry...
  6. pmc Rational strain selection and engineering creates a broad-spectrum, systemically effective oncolytic poxvirus, JX-963
    Steve H Thorne
    Department of Pediatrics and Bio X Program, James H Clark Center, Stanford University School of Medicine, Stanford, California, USA
    J Clin Invest 117:3350-8. 2007
    ..JX-963 therefore holds promise as a rationally designed, targeted virotherapeutic for the systemic treatment of cancer in humans and warrants clinical testing...
  7. pmc Poxvirus multiprotein entry-fusion complex
    Tatiana G Senkevich
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 0445, USA
    Proc Natl Acad Sci U S A 102:18572-7. 2005
    ....
  8. pmc TRAIL gene-armed oncolytic poxvirus and oxaliplatin can work synergistically against colorectal cancer
    M F Ziauddin
    Department of Surgery, University of Pittsburgh School of Medicine and University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA
    Gene Ther 17:550-9. 2010
    ..This combination strategy may provide a new avenue to treating peritoneal carcinomatosis and other types of metastases of colorectal cancer...
  9. pmc Poxvirus protein evolution: family wide assessment of possible horizontal gene transfer events
    Mary R Odom
    Department of Microbiology, University of Alabama Birmingham, Birmingham, AL 35294 2170, USA
    Virus Res 144:233-49. 2009
    To investigate the evolutionary origins of proteins encoded by the Poxviridae family of viruses, we examined all poxvirus protein coding genes using a method of characterizing and visualizing the similarity between these proteins and ..
  10. ncbi The poxvirus vectors MVA and NYVAC as gene delivery systems for vaccination against infectious diseases and cancer
    Carmen E Gomez
    Department of Molecular and Cellular Biology, Centro Nacional de Biotecnologia, CSIC, Ciudad Universitaria Cantoblanco, 28049, Madrid, Spain
    Curr Gene Ther 8:97-120. 2008
    ....
  11. ncbi Genetic identification of novel poxviruses of cetaceans and pinnipeds
    A J Bracht
    Department of Pathobiology, College of Veterinary Medicine, University of Florida, Gainesville, Florida 32610, USA
    Arch Virol 151:423-38. 2006
    ..A significant degree of divergence was observed in sequences of Steller sea lion parapoxviruses, while those of spotted seals and harbor seals (Phoca vitulina) were highly conserved...
  12. pmc Vaccinia virus-encoded ribonucleotide reductase subunits are differentially required for replication and pathogenesis
    Don B Gammon
    Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta, Canada
    PLoS Pathog 6:e1000984. 2010
    ....
  13. ncbi Poxvirus genomes: a phylogenetic analysis
    Caroline Gubser
    Department of Virology, Faculty of Medicine, Imperial College London, St Mary s Campus, Norfolk Place, London W2 1PG, UK
    J Gen Virol 85:105-17. 2004
    ..This suggests that CPV-BR and GRI-90 should be separate species...
  14. ncbi Effective induction of high-titer antibodies by viral vector vaccines
    Simon J Draper
    The Jenner Institute, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Headington, Oxford OX3 7DQ, UK
    Nat Med 14:819-21. 2008
    ..Antibodies induced against a blood-stage malaria antigen by this viral vector platform are highly effective against Plasmodium yoelii parasites in mice and against Plasmodium falciparum in vitro...
  15. ncbi Electron microscopy and antigenic studies of uncharacterized viruses. I. Evidence suggesting the placement of viruses in families Arenaviridae, Paramyxoviridae, or Poxviridae
    H G Zeller
    Division of Vector Borne Viral Diseases, Centers for Disease Control, Fort Collins, Colorado
    Arch Virol 108:191-209. 1989
    ..20 Rhabdoviridae, 14 Reoviridae, one Togaviridae, one Paramyxoviridae (Mapuera virus, from a bat), and one Poxviridae (Yoka virus, from mosquitoes)...
  16. pmc Kinetic analysis of a complete poxvirus transcriptome reveals an immediate-early class of genes
    Erika Assarsson
    Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 105:2140-5. 2008
    ..Additionally, genes within each kinetic class were spatially grouped together in the genome. This genome-wide picture of transcription alters our understanding of how orthopoxviruses regulate gene expression...
  17. pmc Sequence-divergent chordopoxvirus homologs of the o3 protein maintain functional interactions with components of the vaccinia virus entry-fusion complex
    P S Satheshkumar
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    J Virol 86:1696-705. 2012
    ..Analysis of chimeras formed by swapping domains of O3 with those of other proteins indicated that the N-terminal transmembrane segment was responsible for EFC interactions and for the complementation of infectivity...
  18. pmc Expression profiling of the intermediate and late stages of poxvirus replication
    Zhilong Yang
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 3210, USA
    J Virol 85:9899-908. 2011
    ..The differentiation of intermediate and late genes may enhance understanding of poxvirus replication and lead to improvements in expression vectors and recombinant vaccines...
  19. ncbi Multimeric soluble CD40 ligand (sCD40L) efficiently enhances HIV specific cellular immune responses during DNA prime and boost with attenuated poxvirus vectors MVA and NYVAC expressing HIV antigens
    Carmen E Gomez
    Department of Molecular and Cellular Biology, Centro Nacional de Biotecnologia, Ciudad Universitaria Cantoblanco, 28049 Madrid, Spain
    Vaccine 27:3165-74. 2009
    ..These findings provided evidence for the immunostimulatory benefit of sCD40L when DNA and the poxvirus vectors MVA and NYVAC are used as immunogens...
  20. pmc The product of the vaccinia virus L5R gene is a fourth membrane protein encoded by all poxviruses that is required for cell entry and cell-cell fusion
    Alan C Townsley
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 0445, USA
    J Virol 79:10988-98. 2005
    The L5R gene of vaccinia virus is conserved among all sequenced members of the Poxviridae but has no predicted function or recognized nonpoxvirus homolog. Here we provide the initial characterization of the L5 protein...
  21. ncbi Near death experiences: poxvirus regulation of apoptotic death
    John M Taylor
    Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta, Canada T6G 2S2
    Virology 344:139-50. 2006
    ..This review describes the numerous mechanisms by which poxviruses inhibit apoptosis thereby modulating life and death of the cell...
  22. pmc Vaccinia virus H2 protein is an essential component of a complex involved in virus entry and cell-cell fusion
    Tatiana G Senkevich
    Laboratory of Viral Diseases, National Institutes of Health, 4 Center Dr, MSC 0445, Bethesda, MD 20892 0445, USA
    J Virol 79:4744-54. 2005
    ..Therefore, H2 and A28 are the only proteins presently known to be specifically required for vaccinia virus entry and are likely components of a fusion complex...
  23. ncbi Systemic armed oncolytic and immunologic therapy for cancer with JX-594, a targeted poxvirus expressing GM-CSF
    J H Kim
    Department of Pharmacology and MRCCMT, Dong A University Medical College, Busan 604 714, South Korea
    Mol Ther 14:361-70. 2006
    ..JX-594 holds promise as an i.v.-delivered, targeted virotherapeutic. These two tumor models hold promise for the optimization of this approach...
  24. pmc Differential CD4+ versus CD8+ T-cell responses elicited by different poxvirus-based human immunodeficiency virus type 1 vaccine candidates provide comparable efficacies in primates
    Petra Mooij
    Department of Virology, Biomedical Primate Research Centre BPRC, P O Box 3306, 2280 GH Rijswijk, The Netherlands
    J Virol 82:2975-88. 2008
    ..In contrast, in this setting, animals with strong vaccine-induced polyfunctional CD4(+) T-cell responses showed efficacies similar to those with stronger CD8(+) T-cell responses...
  25. pmc Poxviruses as possible vectors for horizontal transfer of retroposons from reptiles to mammals
    Oliver Piskurek
    Faculty of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259 B21 Nagatsuta cho, Midori ku, Yokohama 226 8501, Japan
    Proc Natl Acad Sci U S A 104:12046-51. 2007
    Poxviruses (Poxviridae) are a family of double-stranded DNA viruses with no RNA stage. Members of the genus Orthopoxvirus (OPV) are highly invasive and virulent...
  26. pmc Cell cycle deregulation by a poxvirus partial mimic of anaphase-promoting complex subunit 11
    Min Mo
    Department of Microbiology and Immunology, University of Otago, PO Box 56, Dunedin 9016, New Zealand
    Proc Natl Acad Sci U S A 106:19527-32. 2009
    ..Here, we report a viral mimic of an APC component and reveal an intriguing mechanism by which viruses can manipulate cell cycle progression and, thereby, promote their own replication...
  27. pmc Host-derived pathogenicity islands in poxviruses
    Melissa Da Silva
    Department of Biochemistry and Microbiology, University of Victoria, Victoria, Canada
    Virol J 2:30. 2005
    ..We are interested in evolution of poxvirus genomes and especially how these viruses acquire host-derived genes that are believed to function as virulence factors...
  28. ncbi Genome-based phylogeny of poxvirus
    Ke Xing
    State Key Laboratory for Biocontrol, School of Life Science, Sun Yat Sen Zhongshan University, Guangzhou, PR China
    Intervirology 49:207-14. 2006
    A comprehensive phylogenetic analysis of Poxviridae was performed in this study. Phylogenetic trees were reconstructed from whole genomic information including gene order, gene content, and all conserved gene protein sequences...
  29. pmc Safety, immunogenicity, and efficacy of prime-boost immunization with recombinant poxvirus FP9 and modified vaccinia virus Ankara encoding the full-length Plasmodium falciparum circumsporozoite protein
    Michael Walther
    Centre for Clinical Vaccinology and Tropical Medicine, Nuffield Department of Clinical Medicine, Oxford University, United Kingdom
    Infect Immun 74:2706-16. 2006
    ..Vaccines containing this antigen proved safe and induced modest immune responses but showed no evidence of efficacy in a sporozoite challenge...
  30. pmc Poxvirus immunomodulatory strategies: current perspectives
    J B Johnston
    Robarts Research Institute and Department of Microbiology and Immunology, The University of Western Ontario, London, Canada N6G 2V4
    J Virol 77:6093-100. 2003
  31. ncbi Poxviruses and apoptosis: a time to die
    Helen Everett
    Department of Biochemistry, University of Alberta, 4 63 Medical Sciences Building, Edmonton, T6G 2H7, Alberta, Canada
    Curr Opin Microbiol 5:395-402. 2002
    ..The mechanistic classes of these poxvirus-encoded inhibitors are quite diverse, and indicate that a wide variety of distinct host proteins in cellular apoptotic pathways have been targeted for inhibition by individual poxviruses...
  32. ncbi Host-related immunomodulators encoded by poxviruses and herpesviruses
    G McFadden
    The John P Robarts Research Institute, and Department of Microbiology and Immunology, The University of Western Ontario, London, Canada
    Curr Opin Microbiol 3:371-8. 2000
    ....
  33. pmc Evolution of DNA ligases of nucleo-cytoplasmic large DNA viruses of eukaryotes: a case of hidden complexity
    Natalya Yutin
    National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA
    Biol Direct 4:51. 2009
    ..However, the details of the evolution of these genes that bear on the complexity of the putative ancestral NCLDV and on the evolutionary relationships between viruses and their hosts are not well understood...
  34. ncbi Gene therapy with poxvirus vectors
    Dorota Moroziewicz
    Columbia University, Department of Surgery, 177 Fort Washington Avenue, MHB 7SK, New York, NY 10032, USA
    Curr Opin Mol Ther 7:317-25. 2005
    ..This review focuses on the current status of recombinant poxviruses as vectors for gene therapy of human disease...
  35. pmc Crystal structure of TNFalpha complexed with a poxvirus MHC-related TNF binding protein
    Zhiru Yang
    Division of Biology 114 96, California Institute of Technology, Pasadena, California, USA
    Nat Struct Mol Biol 16:1189-91. 2009
    ..Overlap between the 2L and host TNF receptor-binding sites on TNFalpha rationalizes 2L inhibition of TNFalpha-TNF receptor interactions and prevention of TNFalpha-induced immune responses...
  36. ncbi Equivalent immunogenicity of the highly attenuated poxvirus-based ALVAC-SIV and NYVAC-SIV vaccine candidates in SIVmac251-infected macaques
    Zdenek Hel
    Aventis Pasteur, Ltd 1755 Steeles Avenue West, Toronto, Ontario, M2R 3T4, Canada
    Virology 304:125-34. 2002
    ..Thus, both these vaccine modalities alone or in combination may be suitable candidate vaccines for immune therapy of HIV-1-infected individuals...
  37. ncbi [The time scale in poxvirus evolution]
    I V Babkin
    Mol Biol (Mosk) 40:20-4. 2006
    ..and the sequence of DNA polymerase gene (about 3 kbp) of the viruses belonging to various genera from the family Poxviridae were analyzed...
  38. pmc The 1.51-Angstrom structure of the poxvirus L1 protein, a target of potent neutralizing antibodies
    Hua Poo Su
    Structural Biology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 12441 Parklawn Drive, Rockville, MD 20852, USA
    Proc Natl Acad Sci U S A 102:4240-5. 2005
    ..The structure of L1 is a step in the elucidation of molecular mechanisms common to all poxviruses that may stimulate the design of safer vaccines and new antipoxvirus drugs...
  39. pmc Poxvirus Bioinformatics Resource Center: a comprehensive Poxviridae informational and analytical resource
    Elliot J Lefkowitz
    Department of Microbiology, University of Alabama at Birmingham, BBRB 276 11 1530 3rd Avenue S, Birmingham, AL 35294 2170, USA
    Nucleic Acids Res 33:D311-6. 2005
    ..resources to the scientific community to aid research directed at providing a better understanding of the Poxviridae family of viruses...
  40. pmc Poxvirus orthologous clusters: toward defining the minimum essential poxvirus genome
    Chris Upton
    Department of Biochemistry and Microbiology, University of Victoria, Victoria, British Columbia, Canada
    J Virol 77:7590-600. 2003
    ..We have reannotated and resequenced fragments of this genome and verified that these genes are conserved in Tian Tan. The results for poxvirus genes and genomes are discussed in light of evolutionary processes...
  41. ncbi Poxvirus K7 protein adopts a Bcl-2 fold: biochemical mapping of its interactions with human DEAD box RNA helicase DDX3
    Arnout P Kalverda
    Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, UK
    J Mol Biol 385:843-53. 2009
    ..Furthermore, thermodynamic studies have mapped the K7-binding region to a 30-residue N-terminal fragment of DDX3, ahead of the core RNA helicase domains...
  42. ncbi Tumor necrosis factor receptors encoded by poxviruses
    K M Cunnion
    Department of Pediatrics, Duke University Medical Center, Durham, North Carolina 27705, USA
    Mol Genet Metab 67:278-82. 1999
    ..T2 has also been shown to interfere with TNF-induced apoptosis in vitro. Understanding the role viral TNF receptor homologues play in altering host immune responses may suggest ways to develop specific anti-inflammatory therapeutics...
  43. ncbi Head-to-head comparison on the immunogenicity of two HIV/AIDS vaccine candidates based on the attenuated poxvirus strains MVA and NYVAC co-expressing in a single locus the HIV-1BX08 gp120 and HIV-1(IIIB) Gag-Pol-Nef proteins of clade B
    Carmen Elena Gómez
    Department of Molecular and Cellular Biology, Centro Nacional de Biotecnologia, CSIC, Ciudad Universitaria Cantoblanco, 28049 Madrid, Spain
    Vaccine 25:2863-85. 2007
    ..All of the immunization protocols induced some humoral response against the gp160 protein from HIV-1 clone LAV. Our findings indicate that MVA-B and NYVAC-B meet the criteria to be potentially useful vaccine candidates against HIV/AIDS...
  44. pmc Protection of rhesus monkeys by a DNA prime/poxvirus boost malaria vaccine depends on optimal DNA priming and inclusion of blood stage antigens
    Walter R Weiss
    Naval Medical Research Center, Silver Spring, Maryland, United States of America
    PLoS ONE 2:e1063. 2007
    ..The present study reports three further experiments where we investigate the effects of DNA dose, timing, and formulation. We also compare vaccines utilizing only the pre-erythrocytic antigens with the four antigen vaccine...
  45. pmc Potent oncolytic activity of raccoonpox virus in the absence of natural pathogenicity
    Laura Evgin
    Department of Biochemistry, University of Ottawa, Centre for Cancer Therapeutics, Ottawa Health Research Institute, Ottawa, Ontario, Canada
    Mol Ther 18:896-902. 2010
    ..Raccoonpox virus (RCNV) is a member of the Orthopoxvirus genus of Poxviridae and closely related to vaccinia virus, yet has no known pathogenicity in any mammalian species...
  46. ncbi Poxvirus entry and membrane fusion
    Bernard Moss
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 0445, USA
    Virology 344:48-54. 2006
    ..Future research priorities include delineation of the roles of individual entry/fusion proteins and identification of cell receptors...
  47. pmc Cellular and biochemical differences between two attenuated poxvirus vaccine candidates (MVA and NYVAC) and role of the C7L gene
    José Luis Nájera
    Department of Molecular and Cellular Biology, Centro Nacional de Biotecnologia, CSIC, Ciudad Universitaria Cantoblanco, 28049 Madrid, Spain
    J Virol 80:6033-47. 2006
    ..Overall, our findings demonstrate distinct behavior between NYVAC and MVA strains in cultured cells, as well as a new role for the C7L viral gene as an inhibitor of apoptosis in NYVAC infection...
  48. ncbi Poxvirus cancer therapy
    Philippe Alexandre Gilbert
    Robarts Research Institute, BioTherapeutics Research Group, Siebens Drake Building Room 133, 1400 Western Road, London, Ontario, Canada N6G 2V4
    Recent Pat Antiinfect Drug Discov 1:309-21. 2006
    ..This review will cover their utilization as anti-cancer therapeutics by describing recent patents (2000-2005)...
  49. ncbi Containment of simian immunodeficiency virus infection in vaccinated macaques: correlation with the magnitude of virus-specific pre- and postchallenge CD4+ and CD8+ T cell responses
    Zdenek Hel
    Basic Research Laboratory, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 169:4778-87. 2002
    ..The results presented in this work also further demonstrate the potential of a DNA-prime/attenuated poxvirus-boost vaccine regimen in an animal model that well mirrors human AIDS...
  50. ncbi Poxvirus genome evolution by gene gain and loss
    Austin L Hughes
    Department of Biological Sciences, University of South Carolina, Columbia, SC 29208, USA
    Mol Phylogenet Evol 35:186-95. 2005
    The poxviruses (Poxviridae) are a family of viruses with double-stranded DNA genomes and substantial numbers (often >200) of genes per genome...
  51. ncbi Poxvirus protein N1L targets the I-kappaB kinase complex, inhibits signaling to NF-kappaB by the tumor necrosis factor superfamily of receptors, and inhibits NF-kappaB and IRF3 signaling by toll-like receptors
    Gary DiPerna
    Viral Immune Evasion Group, Department of Biochemistry, Trinity College, Dublin 2, Ireland
    J Biol Chem 279:36570-8. 2004
    ..Furthermore, N1L inhibited IRF3 signaling, which is also regulated by TBK1. These studies define a role for N1L as an immunomodulator of innate immunity by targeting components of NF-kappaB and IRF3 signaling pathways...
  52. pmc Extensive gene gain associated with adaptive evolution of poxviruses
    Aoife McLysaght
    Department of Ecology, Institute for Genomics and Bioinformatics, School of Information and Computer Science, University of California, Irvine, CA 92697, USA
    Proc Natl Acad Sci U S A 100:15655-60. 2003
    ..Here, we use complete genome data from 20 poxvirus genomes to build a robust phylogeny of the Poxviridae and to study patterns of genome evolution...
  53. ncbi Poxvirus tropism
    Grant McFadden
    Department of Microbiology and Immunology, University of Western Ontario, and Robarts Research Institute, Siebens Drake Building, Room 133, 1400 Western Road, London, Ontario N6G 2V4, Canada
    Nat Rev Microbiol 3:201-13. 2005
    ....
  54. pmc Identification of multiple independent horizontal gene transfers into poxviruses using a comparative genomics approach
    Kirsten A Bratke
    Smurfit Institute of Genetics, University of Dublin, Trinity College, Dublin 2, Ireland
    BMC Evol Biol 8:67. 2008
    ..We propose to use synteny conservation around the horizontally transferred gene (HTgene) to distinguish between single and multiple events...
  55. ncbi Vaccinia, Inc.--probing the functional substructure of poxviral replication factories
    Richard C Condit
    Department of Molecular Genetics and Microbiology, University of Florida, P O Box 100266, Gainesville, FL 31610, USA
    Cell Host Microbe 2:205-7. 2007
    ..These factories thus comprise a highly structured virus organelle that isolates and coordinates late viral replication events, facilitating competition for cellular resources...
  56. ncbi Poxviruses and the passive quest for novel hosts
    R L Regnery
    Poxvirus Program, Division of Viral and Rickettsial Diseases, US Centers for Disease Control and Prevention, Mail stop G 43, 1600 Clifton Road, Atlanta, GA 30333, USA
    Curr Top Microbiol Immunol 315:345-61. 2007
    ..e., the Chordopoxvirus subfamily of the family Poxviridae. Brief note is made of examples of members of the genera Leporipoxvirus and Parapoxvirus-like agents that have ..
  57. pmc Identification and nucleotide sequence of the thymidine kinase gene of Shope fibroma virus
    C Upton
    J Virol 60:920-7. 1986
    ..These data suggest a common ancestral origin for at least some of the unique internal regions of the leporipoxviruses and orthopoxviruses as exemplified by SFV and vaccinia virus, respectively...
  58. pmc DNA sequence homology between the terminal inverted repeats of Shope fibroma virus and an endogenous cellular plasmid species
    C Upton
    Mol Cell Biol 6:265-76. 1986
    ..The potential role of such cellular plasmid-like DNA species as a mediator in the exchange of genetic information between the host cell and a cytoplasmically replicating poxvirus is discussed...
  59. pmc Yaba-like disease virus: an alternative replicating poxvirus vector for cancer gene therapy
    Y Hu
    Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Virol 75:10300-8. 2001
    ..YLD virus has favorable characteristics as a vector for cancer gene therapy, and this potential should be explored further...
  60. ncbi Viral vectors for malaria vaccine development
    Shengqiang Li
    PATH Malaria Vaccine Initiative, Bethesda, MD, USA
    Vaccine 25:2567-74. 2007
    ..Understanding the vector's ability to induce an immune response and the expression of malaria antigens in mammalian cells will be critical in designing the next generation of viral-vectored malaria vaccines...
  61. ncbi The genome of molluscum contagiosum virus: analysis and comparison with other poxviruses
    T G Senkevich
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Virology 233:19-42. 1997
    ..Despite the acquisition of unique genes for host interactions and changes in GC content, the physical order and regulation of essential ancestral poxvirus genes have been largely conserved in MCV and OPV...
  62. ncbi Screening predicted coding regions in poxvirus genomes
    C Upton
    Department Biochemistry and Microbiology, University Victoria, BC, Canada
    Virus Genes 20:159-64. 2000
    ..The use of amino acid composition and pI appears to be a generally applicable tool to aid identification of viral ORFs that are unlikely to be functional genes...
  63. ncbi Complete genomic sequence of the Amsacta moorei entomopoxvirus: analysis and comparison with other poxviruses
    A L Bawden
    Department of Molecular Genetics and Microbiology, University of Florida, Gainesville, Florida 32610, USA
    Virology 274:120-39. 2000
    ..The complete genomic sequence of AmEPV paves the way for an understanding and comparison of the molecular properties and pathogenesis between the entomopoxviruses of insects and the more intensively studied vertebrate poxviruses...
  64. ncbi Comparison of a conserved region in fowlpox virus and vaccinia virus genomes and the translocation of the fowlpox virus thymidine kinase gene
    M M Binns
    Institute for Animal Health, Houghton Laboratory, Huntingdon, Cambridgeshire, U K
    J Gen Virol 69:1275-83. 1988
    ..These results are discussed in terms of genome stability in poxviruses and the use of the TK gene as a non-essential region for the introduction of foreign genes into poxviruses...
  65. ncbi Poxvirus Orthologous Clusters (POCs)
    Angelika Ehlers
    Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC V8W 3P6, Canada
    Bioinformatics 18:1544-5. 2002
    ....
  66. pmc Solution structure of the complex between poxvirus-encoded CC chemokine inhibitor vCCI and human MIP-1beta
    Li Zhang
    Department of Biochemistry and Biophysics, Texas A and M University, College Station, TX 77843 2128, USA
    Proc Natl Acad Sci U S A 103:13985-90. 2006
    ..This structure reveals the strategy used by vCCI to tightly bind numerous chemokines while retaining selectivity for the CC chemokine subfamily...
  67. ncbi Fowlpox virus thymidine kinase: nucleotide sequence and relationships to other thymidine kinases
    D B Boyle
    Virology 156:355-65. 1987
    ..Characterization of the FPV TK gene may facilitate the construction of recombinant FPVs as vehicles for the delivery of vaccine antigens to poultry and other avian species...
  68. ncbi Poxviruses: past, present and future
    E J Lefkowitz
    Department of Microbiology, University of Alabama Birmingham, AL 35294 2170, USA
    Virus Res 117:105-18. 2006
    ..Here, we review various comparative analyses of the poxviruses including gene prediction, gene conservation and function, genome organization, and poxvirus taxonomy and evolution...
  69. pmc Structural basis for the binding of the neutralizing antibody, 7D11, to the poxvirus L1 protein
    Hua Poo Su
    Structural Biology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 12441 Parklawn Drive, Rockville, MD 20852, USA
    Virology 368:331-41. 2007
    ..In addition, the sequence and structure of Fab-7D11 will contribute to the development of L1-targeted immunotherapeutics...
  70. ncbi Vaccinia as a vector for gene delivery
    Z Sheng Guo
    University of Pittsburgh, Division of Surgical Oncology, 5150 Center Avenue, Suite 459, Pittsburgh, PA 15232, USA
    Expert Opin Biol Ther 4:901-17. 2004
    ..Other potential strategies for improving this vector for gene delivery will also be discussed in this review...
  71. pmc Identification, cloning, and sequencing of a fragment of Amsacta moorei entomopoxvirus DNA containing the spheroidin gene and three vaccinia virus-related open reading frames
    R L Hall
    Department of Immunology and Medical Microbiology, University of Florida, Gainesville 32610 0266
    J Virol 65:6516-27. 1991
    ..An analysis of open reading frames around the spheroidin gene suggests that the colinear core of "essential genes" typical of the vertebrate poxviruses is absent in A. moorei entomopoxvirus...
  72. ncbi Smallpox vaccines: Past, present, and future
    Janie Parrino
    Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 3017, USA
    J Allergy Clin Immunol 118:1320-6. 2006
    ....
  73. ncbi Protective immunization against murine cytomegalovirus infection using adenoviruses and poxviruses expressing hepatitis B virus chimeras
    Bruna P de Andrade
    Department of Microbiology, Institute for Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil
    Int Microbiol 10:261-9. 2007
    ....
  74. ncbi The potential role of fowlpox virus in rational vaccine design
    Emma L Beukema
    Experimental Therapeutics Laboratory, Hanson Institute, Level 4, Hanson Institute Building, Frome Road, Adelaide, South Australia, 5000, Australia
    Expert Rev Vaccines 5:565-77. 2006
    ..In this review, the issues surrounding the use of fowlpox virus as a vaccine vector and possible strategies for enhancing its efficacy are discussed...
  75. pmc A poxvirus host range protein, CP77, binds to a cellular protein, HMG20A, and regulates its dissociation from the vaccinia virus genome in CHO-K1 cells
    Jye Chian Hsiao
    Graduate Institute of Life Sciences, National Defense Medical Center, Nankang, Taipei, Taiwan
    J Virol 80:7714-28. 2006
    ..In summary, our data revealed that a novel cellular protein, HMG20A, the dissociation of which from viral DNA is regulated by CP77, providing the first cellular target regulated by viral host range CP77 protein...
  76. pmc Invariant Valpha14 chain NKT cells promote Plasmodium berghei circumsporozoite protein-specific gamma interferon- and tumor necrosis factor alpha-producing CD8+ T cells in the liver after poxvirus vaccination of mice
    Simone Korten
    Department of Immunology, Bernhard Nocht Institute for Tropical Medicine, Bernhard Nocht Strasse 74, 20359 Hamburg, Germany
    Infect Immun 73:849-58. 2005
    ..Furthermore, double-positive INF-gamma+/TNF-alpha+ CD8+ T cells were enriched in protected livers, suggesting that cells expressing both of these cytokines may be most relevant for protection...
  77. ncbi Immunology 102 at poxvirus U: avoiding apoptosis
    J L Shisler
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 4 Center Drive, Bethesda, MD 20892-0445, MSC 0445, USA
    Semin Immunol 13:67-72. 2001
    ..These include inhibitors of apoptosis induced by ligand binding to cell surface receptors, peroxides, ultraviolet light, DNA damaging agents and other cell signaling pathways...
  78. ncbi Manipulating the local tumor microenvironment with poxviruses expressing costimulatory molecules
    Howard L Kaufman
    Columbia University Medical Center, 177 Fort Washington Avenue, MHB 7SK, New York, NY 10032, USA
    Ann N Y Acad Sci 1062:41-50. 2005
    ..Herein, we review the general rationale for this approach, discuss the results of ongoing clinical trials, and highlight critical questions that can be addressed in well-designed preclinical and clinical studies...
  79. pmc Characterization of wild-type and cidofovir-resistant strains of camelpox, cowpox, monkeypox, and vaccinia viruses
    Donald F Smee
    Institute for Antiviral Research, Utah State University, Logan, Utah 84322 5600, USA
    Antimicrob Agents Chemother 46:1329-35. 2002
    ..Studies will need to be conducted with cidofovir-resistant monkeypox virus in monkeys to further support these hypotheses...
  80. ncbi Poxvirus immune modulators: functional insights from animal models
    Peter C Turner
    Department of Molecular Genetics and Microbiology, College of Medicine, University of Florida, Gainesville, FL 32610 0266, USA
    Virus Res 88:35-53. 2002
    ..The fact that multiple immune modulators can target the same pathway at different steps may explain why single knockout mutants are not always attenuated in animals...
  81. ncbi Immune evasion by a novel family of viral PHD/LAP-finger proteins of gamma-2 herpesviruses and poxviruses
    Klaus Fruh
    Oregon Health and Science University, Vaccine and Gene Therapy Institute, 505 NW 185th Avenue, Beaverton, OR 97006, USA
    Virus Res 88:55-69. 2002
    ..However, several lines of evidence suggest that they might function as ubiquitin ligases that regulate the intracellular transport of transmembrane proteins through ubiquitination...
  82. ncbi Cancer immunotherapy using virally transduced dendritic cells: animal studies and human clinical trials
    Miriam E Mossoba
    Department of Medical Biophysics, University of Toronto, 67 College Street, Room 426, Toronto, Ontario, M5G 2MI, Canada
    Expert Rev Vaccines 5:717-32. 2006
    ..It covers mouse and nonhuman primate studies, preclinical in vitro human cell experiments and clinical trials...
  83. ncbi Fas-associated death domain-containing protein-mediated antiviral innate immune signaling involves the regulation of Irf7
    Siddharth Balachandran
    Department of Microbiology and Immunology and Sylvester Comprehensive Cancer Center, University of Miami School of Medicine, Miami, FL 33136, USA
    J Immunol 178:2429-39. 2007
    ..These data indicate that FADD's antiviral activity involves regulation of IRF-7-dependent production of IFN-alpha subtypes and consequent induction of secondary antiviral genes...
  84. pmc Identification by a random sequencing strategy of the fowlpoxvirus DNA polymerase gene, its nucleotide sequence and comparison with other viral DNA polymerases
    M M Binns
    Nucleic Acids Res 15:6563-73. 1987
    ..The method used to identify the fowlpoxvirus gene could have applications towards defining genomic organisations in other viral systems...
  85. ncbi Correlates of protective immunity in poxvirus infection: where does antibody stand?
    Vijay Panchanathan
    Division of Biochemistry and Moelcular Biology, Australian National University, Canberra, Australia
    Immunol Cell Biol 86:80-6. 2008
    ..These findings have important clinical implications and would greatly assist the design of therapeutic interventions and new vaccines for smallpox...
  86. ncbi Similar genetic organization between a region of fowlpox virus DNA and the vaccinia virus HindIII J fragment despite divergent location of the thymidine kinase gene
    R Drillien
    Virology 160:203-9. 1987
    ..Despite this intriguing divergence, our results indicate that the Avipoxviruses are more closely related to the Orthopoxviruses than previously suspected...
  87. ncbi Sequence analysis of an 11.2 kilobase, near-terminal, BamHI fragment of fowlpox virus
    F Tomley
    AFRC Institute for Animal Disease Research, Houghton Laboratory, Huntingdon, Cambridgeshire, U K
    J Gen Virol 69:1025-40. 1988
    ..In addition, there are two families of ORFs within the fragment which potentially encode related polypeptides. One of these, family B, contains three ORFs which are related to those of chicken and rat hepatic lectins...
  88. pmc Identification from diverse mammalian poxviruses of host-range regulatory genes functioning equivalently to vaccinia virus C7L
    Xiangzhi Meng
    Department of Microbiology and Immunology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Virology 372:372-83. 2008
    ....
  89. ncbi Tumorigenic poxviruses: analysis of viral DNA sequences implicated in the tumorigenicity of Shope fibroma virus and malignant rabbit virus
    C Upton
    Virology 152:308-21. 1986
    ..Cell. Biol. 6, 265-276) that a subset of this region of the SFV genome is closely related to, and may have been originally derived from, an endogenous covalently closed circular plasmid species detected in uninfected rabbit cells...
  90. ncbi Mucosal vaccine vectors: replication-competent versus replication-deficient poxviruses
    Lukena U Karkhanis
    Department of Infectious Diseases and Microbiology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Curr Pharm Des 13:2015-23. 2007
    ....
  91. ncbi Human cytotoxic CD4+ T cells recognize HLA-DR1-restricted epitopes on vaccinia virus proteins A24R and D1R conserved among poxviruses
    Shibani Mitra-Kaushik
    Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Immunol 179:1303-12. 2007
    ....
  92. pmc Heterologous prime/boost immunization of rhesus monkeys by using diverse poxvirus vectors
    Sampa Santra
    Division of Viral Pathogenesis, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Virol 81:8563-70. 2007
    ..This study supports further exploration of combining recombinant vectors of the same family in prime/boost immunization strategies to optimize vaccine-elicited cellular immune responses...
  93. ncbi Preclinical and clinical studies of recombinant poxvirus vaccines for carcinoma therapy
    Philip M Arlen
    Laboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 1750, USA
    Crit Rev Immunol 27:451-62. 2007
    ..In addition, clinical studies combining vaccines with radiation therapy, chemotherapy, and second-line hormone therapy have provided preliminary evidence of prolongation of time to disease progression and antigen cascade postvaccination...
  94. ncbi Recent advances in the development of adenovirus- and poxvirus-vectored tuberculosis vaccines
    Zhou Xing
    Infectious Diseases Division, Centre for Gene Therapeutics and Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    Curr Gene Ther 5:485-92. 2005
    ..Since modified vaccinia virus Ankara (MVA)- and adenovirus-vectored TB vaccines have been most extensively studied, this review will focus on recent advances in the development and applications of these two viral TB vaccines...
  95. ncbi Antiviral potential of a new generation of acyclic nucleoside phosphonates, the 6-[2-(phosphonomethoxy)alkoxy]-2,4-diaminopyrimidines
    Erik De Clercq
    Address correspondence to Erik De Clercq, Rega Institute for Medical Research, K U Leuven, Minderbroedersstraat 10, Leuven B 3000, Belgium
    Nucleosides Nucleotides Nucleic Acids 24:331-41. 2005
    ..The 6-[2-(phosphonomethoxy)alkoxy]-2,4-diaminopyrimidines offer substantial potential for the treatment of a broad range of retro-, hepadna-, herpes-, adeno-, and poxvirus infections...
  96. ncbi Cowpox virus CrmA, Myxoma virus SERP2 and baculovirus P35 are not functionally interchangeable caspase inhibitors in poxvirus infections
    Rajkumar Nathaniel
    University of Florida, College of Medicine, Department of Molecular Genetics and Microbiology, PO Box 100266, University of Florida, Gainesville, FL 32610 0266, USA
    J Gen Virol 85:1267-78. 2004
    ..Therefore, CrmA and SERP2 were not functionally interchangeable during infection of CAMs or rabbits, implying that these serpins have activities that are not evident from biochemical studies with human caspases...
  97. ncbi Development of a non-immunising, paraspecific vaccine from attenuated pox viruses: a new type of vaccine
    A Mayr
    Institute for Medical Microbiology, Infectious and Epidemic Diseases, Ludwig Maximilians University of Munich, D 80539 Munchen
    New Microbiol 26:7-12. 2003
    ....
  98. pmc Recombinant poxvirus boosting of DNA-primed rhesus monkeys augments peak but not memory T lymphocyte responses
    Sampa Santra
    Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 101:11088-93. 2004
    ..This study, therefore, indicates that the steady-state memory, rather than the peak effector vaccine-elicited T lymphocyte responses, may be the critical immune correlate of protection for a CTL-based HIV vaccine...
  99. ncbi A triad of costimulatory molecules synergize to amplify T-cell activation in both vector-based and vector-infected dendritic cell vaccines
    J Schlom
    Laboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Artif Cells Blood Substit Immobil Biotechnol 31:193-228. 2003
    ..In vivo, peptide-pulsed DCs infected with TRICOM vectors induced cytotoxic T lymphocyte activity markedly and significantly greater than peptide-pulsed DCs...
  100. pmc Pilot study of vaccination with recombinant CEA-MUC-1-TRICOM poxviral-based vaccines in patients with metastatic carcinoma
    James L Gulley
    Laboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
    Clin Cancer Res 14:3060-9. 2008
    ..Carcinoembryonic antigen (CEA) and MUC-1 are overexpressed in a substantial proportion of common solid carcinomas. The primary end point of this study was vaccine safety, with immunologic and clinical responses as secondary end points...
  101. ncbi New approaches to the prevention and eradication of rabies
    Bernhard Dietzschold
    Department of Microbiology and Immunology, Thomas Jefferson University, 1020 Locust Street, Suite 459, Philadelphia, PA 19107, USA
    Expert Rev Vaccines 2:399-406. 2003
    ..Finally, we discuss new immune therapeutics aimed at replacing the conventional administration of antirabies immunoglobulin used in rabies post-exposure prophylaxis in humans...

Research Grants62

  1. N-methanocarbathymidine (N-MCT) for the Treatment of Herpes and Pox Virus Infecti
    Aquilur Rahman; Fiscal Year: 2010
    ..N&N proposes to develop N-MCT as a therapeutic against the Herpesviridae, Papillomaviridae and Poxviridae genera of Class I dsDNA viruses, which include HSV-1, HSV-2, HSV-8, VZV, EBV, smallpox, Vaccinia, cowpox, and ..
  2. Cellular Immunity to Category A-C Viruses in Humans
    ROBERT WILLIAM FINBERG; Fiscal Year: 2013
    ....
  3. N-methanocarbathymidine (N-MCT) for the Treatment of Herpes and Pox Virus Infecti
    Aquilur Rahman; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Diseases associated with the Poxviridae (smallpox, vaccinia and cowpox viruses), and Herpesviridae (HSV-1, HSV-2, HSV-8, VZV, EBV) dsDNA viruses represent major worldwide public health problems...
  4. Immune Mechanisms That Control Ectromelia Virus Infection
    Luis J Sigal; Fiscal Year: 2013
    ..The results from this Project will provide a comprehensive picture of the innate response to a peripheral virus infection. ..
  5. Host defense against poxviruses and viral immune evasion
    Liang Deng; Fiscal Year: 2011
    ..abstract_text> ..
  6. Encapsidation of the poxvirus genome
    Paula Traktman; Fiscal Year: 2012
    ..Our investigations of genome encapsidation will provide fundamental insights into this poorly understood facet of the viral life cycle and define new targets for the development of rational antiviral therapies. ..
  7. The Pox Virion Molecular Interactome
    Paul D Gershon; Fiscal Year: 2013
    ....
  8. Mechanisms of pox virus motility and release
    Daniel Kalman; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The poxviridae family members vaccinia and variola (a Class A pathogen) enter mammalian cells, replicate extranuclearly, and produce virions that travel to the cell surface along microtubules, fuse ..
  9. NLR Family Proteins: Mechanisms and Regulation
    John C Reed; Fiscal Year: 2012
    ..The proposed project is relevant to several diseases with unmet medical needs, including autoimmunty, chronic inflammation, allergy, infection, and vaccines. ..
  10. Stage-Specific Inhibitors of Orthopoxviruses
    John H Connor; Fiscal Year: 2012
    ..Effective probes will be developed with the aim of providing new tools to further dissect the mechanism of viral infection and spread, and may also lead to one or more new drugs to protect against poxvirus infection. ..
  11. Vaccinia Virus Genetics and Morphogenesis
    Richard C Condit; Fiscal Year: 2013
    ....
  12. Study of gamma interferon agonists/mimetics
    Howard M Johnson; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVENCE: Our interferon mimetic is a novel therapeutic for treating viral and other infectious diseases. The SOCS-1 antagonist should provide a new paradigm to boosting the immune system against infections and cancer. ..
  13. Therapeutics that target processivity complex proteins of pox and other viruses
    ROBERT PAUL RICCIARDI; Fiscal Year: 2013
    ..The Broad-Spectrum action of certain of these therapeutics will hopefully generate new anti-virals that can be used to prevent current infections that are of medical significance as well as block other important agents of bioterrorism. ..
  14. Mechanisms of Viral DNA Packaging: Biophysical, Biochemical, &Genetic Analysis
    Douglas E Smith; Fiscal Year: 2013
    ..abstract_text> ..
  15. Broad-spectrum, small-molecule inhibitors of bunyaviruses
    Robert D Allen; Fiscal Year: 2010
    ..nontoxic compounds with antiviral activities that extend beyond the family Bunyaviridae against viruses in the Poxviridae, Togaviridae, and Flaviviridae families, presumably by targeting host pathways essential for replication of a ..
  16. VACCINIA DNA REPLICATION
    Paula Traktman; Fiscal Year: 2013
    ..Furthermore, we will use a targeted siRNA library to identify cellular membrane-trafficking proteins that contribute to the reorganization of the ER for the purpose of replication factory assembly. ..
  17. Evasion of antiviral protection by poxvirus-encoded interferon antagonists
    Sergei V Kotenko; Fiscal Year: 2010
    ....
  18. Mechanisms of vaccinia virus dissemination
    HERVE F AGAISSE; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The Orthopoxvirus genus of the family Poxviridae includes both the causative agent of smallpox, variola virus, and the vaccine strain used for smallpox eradication, Vaccinia virus...
  19. XVII International Poxvirus, Asfivirus and Indorviurs Symposium
    Bertram L Jacobs; Fiscal Year: 2010
    ....
  20. VACCINIA VIRUS BIOCHEMICAL GENETICS
    Richard C Condit; Fiscal Year: 2013
    ....
  21. Structure-function studies on IL-18, IL-18 binding proteins and receptors
    Junpeng Deng; Fiscal Year: 2012
    ..It may benefit efforts in developing treatments against some autoimmune and inflammatory diseases, in developing immunotherapies against other infectious diseases and cancer and in combating bioterrorism. ..
  22. Intracellular Defenses Against Foreign DNA: Insights From Poxvirus-Infected Cells
    Matthew S Wiebe; Fiscal Year: 2013
    ..At the conclusion of this work, the insights gained will further our understanding not only of poxviral- host interaction, but will be broadly significant to the understanding of immune responses to DNA in general. ..
  23. Poxvirus Modulation of Immune Responses
    Janice S Blum; Fiscal Year: 2010
    ..These research projects will be supported by an administrative core, and two research facilities including a virus core and a pulmonary biology core, each designed to facilitate studies of viral pathogenesis and host immunity...
  24. Structural studies of DNA resolvases involved in hairpin telomere maintenance
    Hideki Aihara; Fiscal Year: 2013
    ..Furthermore, our research may contribute to better understanding of many DNA rearrangement machineries that share similar reaction chemistries with the DNA resolvases studied here. ..
  25. Broad spectrum therapeutics targeting resolvase enzymes
    Frederic D Bushman; Fiscal Year: 2010
    ..and two pieces of equipment will be purchased (a fluorescence plate reader and a -80[unreadable]C freezer) from American sources. advancing the goals of the ARRA. sources, thereby advancing the goals of the ARRA...
  26. Poxvirus interface with skin immune system, development of anti-poxvirus drugs
    Liang Deng; Fiscal Year: 2010
    ..It will also allow us to develop novel antipoxvirus drugs and test them in an in vivo mouse skin model. ..
  27. Improving Vaccinia for Peritoneal Tumors: Enhanced Distribution &Immune Evasion
    David L Bartlett; Fiscal Year: 2013
    ..The significance of the A34R deletion with enhanced release of the vvDD will be important for all poxvirus clinical applications. ..
  28. Inhibitors of HIV-induced downregulation of HLA class I
    Juan Lama; Fiscal Year: 2013
    ..PHS 398/2590 (Rev. 06/09) Page Continuation Format Page ..
  29. A Novel Systemic and Mucosal Adjuvant for Biodefense
    Mario Barro; Fiscal Year: 2010
    ..tularensis;Aim 3 - in collaboration with the Center for Comparative Medicine at U.C.-Davis, to determine the level of adjuvant activity in primates;and Aim 4 - to develop a scalable manufacturing process for adjuvant production. ..
  30. Defining TLR9 regulatory sequences in natural DNA; implication for vaccine develo
    Laurent Coscoy; Fiscal Year: 2010
    ..Here, we propose to identify all sequence motifs (up to 8mers) that stimulate or inhibit the physiological (truncated) form of TLR9 and determine whether the frequency of these sequences are modulated in DNA viruses. ..
  31. Orally Active Nucleoside Phosphonates for Hepatitis C Virus
    ROBERT TURNER SCHOOLEY; Fiscal Year: 2013
    ..abstract_text> ..
  32. MRCE for Biodefense and Emerging Infectious Dieseases
    Herbert W Virgin; Fiscal Year: 2013
    ..The MRCE is uniquely positioned to serve Region VII and the nation through an exceptional program that addresses the most immediate and urgent national biodefense needs. ..
  33. Immune modulation mechanism mediated by poxvirus IL-18 binding protein
    Yan Xiang; Fiscal Year: 2011
    ..A comprehensive understanding of IL-18BP functioning mechanism and in vivo effects will lead to new therapies for poxvirus diseases and better poxvirus-based vaccines. ..
  34. Retrocyclin reinforcement of pulmonary defenses against viral aerosols
    Robert Lehrer; Fiscal Year: 2007
    ..HPIV3 (Paramyxoviridae), West Nile and Yellow Fever virus (Flaviviridae) SARS-CoV (Coronaviridae), Vaccinia (Poxviridae), VEE, an alphavirus (Togaviridae), and Tacaribe virus (Arenaviridae) 2...
  35. Mechanisms for NK Cell Activation in Vaccinia Virus Control
    Yiping Yang; Fiscal Year: 2013
    ....
  36. Probing the Universality and Function of Single dsDNA Viral Packaging Motors
    James M Tsay; Fiscal Year: 2010
    ..By understanding the detailed mechanochemistry as well as the additional proteins necessary for the survival of these viruses, we may envision new strategies to regulate their infectivity. ..
  37. Structure and Design of Cytokine and Chemokine Binding Proteins
    Mark R Walter; Fiscal Year: 2010
    ..In particular, these studies could help us understand how to harness the immune system to eliminate hepatitis C and/or HIV infections. ..
  38. Uncovering poxvirus proteins involved in regulating the IMV to EV transition
    Brian M Ward; Fiscal Year: 2013
    ..The results obtained will provide greater insight into the molecular mechanism poxviruses use to regulate the formation of the two forms of infectious virions and give us a better understanding of poxvirus morphogenesis and egress. ..
  39. Evolutionary potential of a model poxvirus
    Nels C Elde; Fiscal Year: 2013
    ..abstract_text> ..
  40. Poxvirus adverse effects on cardiac cells and the heart
    Barbara Sherry; Fiscal Year: 2005
    ..Studies proposed in this R21 application will provide the foundation for future in-depth studies with the goal of improving current and future smallpox vaccines. ..
  41. VACCINIA VIRUS LATE TRANSCRIPTION FACTOR
    Cynthia Wright; Fiscal Year: 2003
    ..Also, it is expected that knowledge of the transcriptional processes of the virus will increase its application as a vector for gene expression and vaccine use. ..
  42. Automated Simultaneous Detection of Bioterrorism Agents
    David Ecker; Fiscal Year: 2005
    ..the instrumentation needs further development and validation for NIAID/CDC-priority pathogens such as the Poxviridae, Arenaviridae, Bunyaviridae, Flaviviridae, Togaviridae (especially VEE), and Filoviridea families and the alpha, ..
  43. ANALOGS OF HPMPA FOR TREATMENT OF SMALLPOX
    Karl Hostetler; Fiscal Year: 2005
    ..HPMPA analogs are broad spectrum antivirals and other uses are anticipated which could make commercial development more likely. ..
  44. MULTISCALE MODELING TOOLS FOR STRUCTURAL BIOLOGY
    Charles Brooks; Fiscal Year: 2009
    ..abstract_text> ..
  45. Host proteins in Vaccinia viral membrane biogenesis
    Victor Hsu; Fiscal Year: 2004
    ..abstract_text> ..
  46. XIV International Poxvirus/Iridovirus Workshop
    EDWARD NILES; Fiscal Year: 2002
    ..We expect thr-lt the 2002 Workshop will prove to be as stimulating and as informative as its predecessors. ..
  47. Smallpox subunit vaccine in the C-PERL expression system
    GEORGE BUCHMAN; Fiscal Year: 2005
    ..Success in these three milestones will allow rapid progress towards Phase l/ll human trials and toward eventual use of the vaccine in the general population. ..
  48. RNA INTERFERENCE AS A WEAPON AGAINST BIOTERRORISM
    Judy Lieberman; Fiscal Year: 2007
    ..abstract_text> ..
  49. BIOLOGY OF VACCINIA VIRUS ACYLPROTEINS
    Dennis Hruby; Fiscal Year: 2005
    ..The results of these experiments should extend our knowledge of the VV replicative process and enhance our understanding of the biology of acylproteins in general. ..
  50. Host responses to smallpox and monkeypox
    David Relman; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  51. DEVELOPMENT OF POXVIRUS PROTEINASE INHIBITORS
    Dennis Hruby; Fiscal Year: 2002
    ..An event which we all hope never transpires, but for which preparation is vital. ..
  52. Viral PYRIN-only proteins as suppressors of the host immune response
    Christian Stehlik; Fiscal Year: 2007
    ..The here proposed work extends our long-term goal to define pathogen-host interactions and their effect on the immune response. [unreadable] [unreadable]..
  53. Inhibitors of pox virus Holliday juction resolvase
    Anca Segall; Fiscal Year: 2005
    ....
  54. Translation Research in Plasmodium vivax
    Socrates Herrera; Fiscal Year: 2005
    ..abstract_text> ..
  55. Novel Inhibitors of Poxvirus Replication
    EDWARD NILES; Fiscal Year: 2005
    ..These studies will permit us to determine whether safe effective anti-poxvirus drugs can be synthesized based on their ability to inhibit virus replication through inhibition of early mRNA synthesis. ..
  56. ORTHOPOXVIRUS GENOMICS AND BIOINFORMATICS RESOURCE CENTE
    R Buller; Fiscal Year: 2003
    ..abstract_text> ..
  57. Poxvirus regulation of NF-kB: Mechanisms for virulence
    Joanna Shisler; Fiscal Year: 2009
    ..Results obtained here may prove useful in devising novel strategies to overcome pathogenic effects of vaccinia, with implications for enhancing safety and efficacy of a smallpox vaccine. ..
  58. Study of gamma interferon agonists/mimetics
    Howard Johnson; Fiscal Year: 2007
    ..3. Protection of mice against lethal ectromelia virus infection by IFN mimetics and SOCS-1 antagonists. 4. Determine immunological aspects of treatment of mice with IFN mimetics. Effect of SOCS-1 antagonist. ..
  59. Natural Killer Cell Mediated Control of Vaccinia Virus
    Anthony French; Fiscal Year: 2007
    ..The proposed work will occur under the mentorship of Dr. Wayne Yokoyama a recognized pioneer in the NK cell field who has successfully trained numerous graduate students and postdoctoral fellows. [unreadable] [unreadable]..
  60. Innate Immunomodulating Genes of Smallpox Vaccines
    Tilahun Yilma; Fiscal Year: 2009
    ..Preliminary safety and efficacy testing of our vaccines will be first determined in a murine model before testing the most promising recombinants in the more expensive nonhuman primate model. ..
  61. VIRAL INHIBITION OF HOST DEFENSES
    DAVID PICKUP; Fiscal Year: 2000
    ....
  62. MOLLUSCUM CONTAGIOSUM VIRUS TOPOISOMERASE
    Frederic Bushman; Fiscal Year: 2002
    ..In addition, poxviruses have been implicated as possible biological warfare agents; thus poxvirus topoisomerase inhibitors might be use for treating such infections. ..