simian virus 40

Summary

Summary: A species of POLYOMAVIRUS originally isolated from Rhesus monkey kidney tissue. It produces malignancy in human and newborn hamster kidney cell cultures.

Top Publications

  1. ncbi Simian Virus 40 depends on ER protein folding and quality control factors for entry into host cells
    Mario Schelhaas
    Institute of Biochemistry, Schafmattstrasse 18, ETH Hoenggerberg, ETH Zurich, CH 8093, Zurich, Switzerland
    Cell 131:516-29. 2007
  2. pmc Clathrin- and caveolin-1-independent endocytosis: entry of simian virus 40 into cells devoid of caveolae
    Eva Maria Damm
    Institute of Biochemistry, Swiss Federal Institute of Technology Zurich ETHZ, CH 8093 Zurich, Switzerland
    J Cell Biol 168:477-88. 2005
  3. doi GM1 structure determines SV40-induced membrane invagination and infection
    Helge Ewers
    ETH Zurich, Institute of Biochemistry, HPM E, Schafmattstrasse 18, 8093 Zurich, Switzerland
    Nat Cell Biol 12:11-8; sup pp 1-12. 2010
  4. ncbi PML-nuclear bodies accumulate DNA in response to polyomavirus BK and simian virus 40 replication
    Asne Jul-Larsen
    Section of Anatomy and Cell Biology, Department of Biomedicine, University of Bergen, 5009, Norway
    Exp Cell Res 298:58-73. 2004
  5. pmc A distinct first replication cycle of DNA introduced in mammalian cells
    Gurangad S Chandok
    Department of Biochemistry and Molecular Biology, Penn State University, University Park, PA 16801, USA
    Nucleic Acids Res 39:2103-15. 2011
  6. pmc Induction of interferon-stimulated genes by Simian virus 40 T antigens
    Abhilasha V Rathi
    Department of Biological Sciences, University of Pittsburgh, 559 Crawford Hall, Pittsburgh, PA 15260, USA
    Virology 406:202-11. 2010
  7. doi Uncatalyzed assembly of spherical particles from SV40 VP1 pentamers and linear dsDNA incorporates both low and high cooperativity elements
    Santanu Mukherjee
    Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Virology 397:199-204. 2010
  8. pmc Formation of transitory intrachain and interchain disulfide bonds accompanies the folding and oligomerization of simian virus 40 Vp1 in the cytoplasm
    Peggy P Li
    Molecular Biology Institute and Department of Molecular, Cell, and Developmental Biology, University of California, 405 Hilgard Avenue, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 99:1353-8. 2002
  9. pmc Simian virus 40 infection triggers a balanced network that includes apoptotic, survival, and stress pathways
    Veronika Butin-Israeli
    Department of Hematology, Hebrew University Hadassah Medical School, Jerusalem, Israel 91120
    J Virol 84:3431-42. 2010
  10. pmc Ataxia telangiectasia-mutated damage-signaling kinase- and proteasome-dependent destruction of Mre11-Rad50-Nbs1 subunits in Simian virus 40-infected primate cells
    Xiaorong Zhao
    Department of Biological Sciences, Vanderbilt University, Nashville, Tennessee 37235 1634, USA
    J Virol 82:5316-28. 2008

Research Grants

  1. VIRAL REGULATION OF RIBOSOMAL RNA TRANSCRIPTION
    Lucio Comai; Fiscal Year: 2002
  2. MICROSCOPY & IMAGE ANALYSIS OF UNSTAINED MACROMOLECULES
    Timothy Baker; Fiscal Year: 1992
  3. MICROSCOPY & IMAGE ANALYSIS OF UNSTAINED MACROMOLECULES
    Timothy Baker; Fiscal Year: 1993
  4. Simian Virus 40 (SV40) uncoating and penetration
    Daniel Hebert; Fiscal Year: 2009
  5. INTRACELLULAR MECHANISMS OF GLUCOCORTICOID ACTION
    Donald Defranco; Fiscal Year: 1999
  6. A chemical genetic approach to inhibiting T-ag assembly on the viral origin
    Peter Bullock; Fiscal Year: 2007
  7. Pathogenesis of mesothelioma
    Michele Carbone; Fiscal Year: 2006
  8. Pathogenesis of mesothelioma
    Michele Carbone; Fiscal Year: 2007
  9. Pathogenesis of mesothelioma
    Michele Carbone; Fiscal Year: 2009
  10. Pathogenesis of mesothelioma
    Michele Carbone; Fiscal Year: 2010

Detail Information

Publications267 found, 100 shown here

  1. ncbi Simian Virus 40 depends on ER protein folding and quality control factors for entry into host cells
    Mario Schelhaas
    Institute of Biochemistry, Schafmattstrasse 18, ETH Hoenggerberg, ETH Zurich, CH 8093, Zurich, Switzerland
    Cell 131:516-29. 2007
    Cell entry of Simian Virus 40 (SV40) involves caveolar/lipid raft-mediated endocytosis, vesicular transport to the endoplasmic reticulum (ER), translocation into the cytosol, and import into the nucleus...
  2. pmc Clathrin- and caveolin-1-independent endocytosis: entry of simian virus 40 into cells devoid of caveolae
    Eva Maria Damm
    Institute of Biochemistry, Swiss Federal Institute of Technology Zurich ETHZ, CH 8093 Zurich, Switzerland
    J Cell Biol 168:477-88. 2005
    b>Simian Virus 40 (SV40) has been shown to enter host cells by caveolar endocytosis followed by transport via caveosomes to the endoplasmic reticulum (ER)...
  3. doi GM1 structure determines SV40-induced membrane invagination and infection
    Helge Ewers
    ETH Zurich, Institute of Biochemistry, HPM E, Schafmattstrasse 18, 8093 Zurich, Switzerland
    Nat Cell Biol 12:11-8; sup pp 1-12. 2010
    Incoming simian virus 40 (SV40) particles enter tight-fitting plasma membrane invaginations after binding to the carbohydrate moiety of GM1 gangliosides in the host cell plasma membrane through pentameric VP1 capsid proteins...
  4. ncbi PML-nuclear bodies accumulate DNA in response to polyomavirus BK and simian virus 40 replication
    Asne Jul-Larsen
    Section of Anatomy and Cell Biology, Department of Biomedicine, University of Bergen, 5009, Norway
    Exp Cell Res 298:58-73. 2004
    ..labeling to demonstrate that PML-NBs accumulate newly synthesized DNA in cells infected by the polyomaviruses simian virus 40 (SV40) or polyomavirus BK (BKV)...
  5. pmc A distinct first replication cycle of DNA introduced in mammalian cells
    Gurangad S Chandok
    Department of Biochemistry and Molecular Biology, Penn State University, University Park, PA 16801, USA
    Nucleic Acids Res 39:2103-15. 2011
    ..This work demonstrates, for the first time, differences in the replication progression during the first and subsequent replication cycles in mammalian cells...
  6. pmc Induction of interferon-stimulated genes by Simian virus 40 T antigens
    Abhilasha V Rathi
    Department of Biological Sciences, University of Pittsburgh, 559 Crawford Hall, Pittsburgh, PA 15260, USA
    Virology 406:202-11. 2010
    b>Simian virus 40 (SV40) large T antigen (TAg) is a multifunctional oncoprotein essential for productive viral infection and for cellular transformation...
  7. doi Uncatalyzed assembly of spherical particles from SV40 VP1 pentamers and linear dsDNA incorporates both low and high cooperativity elements
    Santanu Mukherjee
    Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Virology 397:199-204. 2010
    ..These data suggest a DNA saturation-dependent nucleation event based on non-specific pentamer-DNA interaction that controls assembly and the ultimate capsid geometry...
  8. pmc Formation of transitory intrachain and interchain disulfide bonds accompanies the folding and oligomerization of simian virus 40 Vp1 in the cytoplasm
    Peggy P Li
    Molecular Biology Institute and Department of Molecular, Cell, and Developmental Biology, University of California, 405 Hilgard Avenue, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 99:1353-8. 2002
    Pentamer formation by Vp1, the major capsid protein of simian virus 40, requires an interdigitation of structural elements from the Vp1 monomers [Liddington, R. C., Yan, Y., Moulai, J., Sahli, R., Benjamin, T. L. & Harrison, S. C...
  9. pmc Simian virus 40 infection triggers a balanced network that includes apoptotic, survival, and stress pathways
    Veronika Butin-Israeli
    Department of Hematology, Hebrew University Hadassah Medical School, Jerusalem, Israel 91120
    J Virol 84:3431-42. 2010
    The infection process by simian virus 40 (SV40) and entry of its genome into nondividing cells are only partly understood...
  10. pmc Ataxia telangiectasia-mutated damage-signaling kinase- and proteasome-dependent destruction of Mre11-Rad50-Nbs1 subunits in Simian virus 40-infected primate cells
    Xiaorong Zhao
    Department of Biological Sciences, Vanderbilt University, Nashville, Tennessee 37235 1634, USA
    J Virol 82:5316-28. 2008
    Although the mechanism of simian virus 40 (SV40) DNA replication has been extensively investigated with cell extracts, viral DNA replication in productively infected cells utilizes additional viral and host functions whose interplay ..
  11. pmc Frequent detection of polyomaviruses in stool samples from hospitalized children
    John A Vanchiere
    Department of Pediatrics, Section of Infectious Diseases, Baylor College of Medicine, Houston, Texas, USA
    J Infect Dis 192:658-64. 2005
    ..PCR) assay that could detect a conserved region in the large T antigen gene of BKV, JC virus (JCV), and simian virus 40 (SV40)...
  12. doi Specific antibodies reacting with simian virus 40 capsid protein mimotopes in serum samples from healthy blood donors
    Alfredo Corallini
    Section of Microbiology, University of Ferrara, 44121 Ferrara, Italy
    Hum Immunol 73:502-10. 2012
    b>Simian virus 40 (SV40), a small DNA tumor virus, was inadvertently administered to human populations with the use of contaminated vaccines...
  13. pmc Simian virus 40 small T antigen activates AMPK and triggers autophagy to protect cancer cells from nutrient deprivation
    Sravanth Hindupur Kumar
    Department of Molecular Reproduction, Development, and Genetics, Indian Institute of Science, Bangalore 560012, India
    J Virol 83:8565-74. 2009
    ..Using an in vitro transformation model where the presence of the simian virus 40 (SV40) small T (ST) antigen has been shown to be critical for tumorigenic transformation, we investigated ..
  14. pmc Interaction of the Vp3 nuclear localization signal with the importin alpha 2/beta heterodimer directs nuclear entry of infecting simian virus 40
    Akira Nakanishi
    Department of Molecular, Cell, and Developmental Biology and Molecular Biology Institute, University of California at Los Angeles, Los Angeles, California 90095, USA
    J Virol 76:9368-77. 2002
    ..We show that the nuclear entry of simian virus 40 involves a dynamic interplay between two distinct interiorly situated capsid NLSs, the Vp1 NLS and the Vp3 ..
  15. pmc Multiple DNA damage signaling and repair pathways deregulated by simian virus 40 large T antigen
    Sergei Boichuk
    University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15213, USA
    J Virol 84:8007-20. 2010
    We demonstrated previously that expression of simian virus 40 (SV40) large T antigen (LT), without a viral origin, is sufficient to induce the hallmarks of a cellular DNA damage response (DDR), such as focal accumulation of gamma-H2AX ..
  16. pmc Role of endosomes in simian virus 40 entry and infection
    Sabrina Engel
    ETH Zurich, Institute of Biochemistry, Schafmattstrasse 18, 8093 Zurich, Switzerland
    J Virol 85:4198-211. 2011
    After binding to its cell surface receptor ganglioside GM1, simian virus 40 (SV40) is endocytosed by lipid raft-mediated endocytosis and slowly transported to the endoplasmic reticulum, where partial uncoating occurs...
  17. pmc Simian virus 40 large T antigen disrupts genome integrity and activates a DNA damage response via Bub1 binding
    Jennifer Hein
    Hillman Cancer Center, Research Pavilion Suite 1 8, 5117 Centre Avenue, Pittsburgh, PA 15213, USA
    J Virol 83:117-27. 2009
    b>Simian virus 40 (SV40) large T antigen (LT) is a multifunctional protein that is important for viral replication and oncogenic transformation...
  18. ncbi Hepatitis C virus NS3 and simian virus 40 T antigen helicases displace streptavidin from 5'-biotinylated oligonucleotides but not from 3'-biotinylated oligonucleotides: evidence for directional bias in translocation on single-stranded DNA
    Patrick D Morris
    Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    Biochemistry 41:2372-8. 2002
    ..The dependence of the reaction with NS3 on the oligonucleotide length suggests that multiple NS3 monomers are necessary for optimal activity...
  19. pmc Caveolar endocytosis of simian virus 40 is followed by brefeldin A-sensitive transport to the endoplasmic reticulum, where the virus disassembles
    Leonard C Norkin
    Department of Microbiology, University of Massachusetts, Amherst, Massachusetts 01003 5720, USA
    J Virol 76:5156-66. 2002
    b>Simian virus 40 (SV40) enters cells by atypical endocytosis mediated by caveolae that transports the virus to the endoplasmic reticulum (ER) instead of to the endosomal-lysosomal compartment, which is the usual destination for viruses ..
  20. ncbi Lipid rafts and caveolae as portals for endocytosis: new insights and common mechanisms
    Robert G Parton
    Institute for Molecular Bioscience, Centre for Microscopy and Microanalysis, and School of Biomedical Sciences, University of Queensland, Queensland, 4072, Australia
    Traffic 4:724-38. 2003
    ..This review examines the current evidence for the involvement of rafts and caveolae in endocytosis and the molecular players involved in their regulation...
  21. ncbi SV40 multiple tissue infection and asbestos exposure in a hyperendemic area for malignant mesothelioma
    Manola Comar
    Department of Public Medicine Sciences, University of Trieste, Trieste, Italy
    Cancer Res 67:8456-9. 2007
    ..045). This survey shows that SV40 sustains infections in multiple tissues in malignant mesothelioma patients from a geographic area affected with asbestos-related mesothelioma...
  22. pmc Conformational rearrangements of SV40 large T antigen during early replication events
    Isabel Cuesta
    Unidad de Biocomputación, Centro Nacional de Biotecnologia CSIC, C Darwin 3, 28049 Madrid, Spain
    J Mol Biol 397:1276-86. 2010
    The Simian virus 40 (SV40) large tumor antigen (LTag) functions as the replicative helicase and initiator for viral DNA replication...
  23. pmc Simian virus 40 activates ATR-Delta p53 signaling to override cell cycle and DNA replication control
    Gabor Rohaly
    Heinrich Pette Institut für Experimentelle Virologie und Immunologie, Martinistr 52, D 20251 Hamburg, Germany
    J Virol 84:10727-47. 2010
    During infection, simian virus 40 (SV40) attempts to take hold of the cell, while the host responds with various defense systems, including the ataxia-telangiectasia mutated/ATM-Rad3 related (ATM/ATR)-mediated DNA damage response ..
  24. pmc Adenovirus E1A, simian virus 40 tumor antigen, and human papillomavirus E7 protein share the capacity to disrupt the interaction between transcription factor E2F and the retinoblastoma gene product
    S Chellappan
    Howard Hughes Medical Institute, Department of Microbiology and Immunology, Duke University Medical Center, Durham, NC 27710
    Proc Natl Acad Sci U S A 89:4549-53. 1992
    The adenovirus E1A gene product, the simian virus 40 large tumor antigen, and the human papillomavirus E7 protein share a short amino acid sequence that constitutes a domain required for the transforming activity of these proteins...
  25. pmc SR alpha promoter: an efficient and versatile mammalian cDNA expression system composed of the simian virus 40 early promoter and the R-U5 segment of human T-cell leukemia virus type 1 long terminal repeat
    Y Takebe
    Department of Molecular Biology, DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, California 94304
    Mol Cell Biol 8:466-72. 1988
    We developed a novel promoter system, designated SR alpha, which is composed of the simian virus 40 (SV40) early promoter and the R segment and part of the U5 sequence (R-U5') of the long terminal repeat of human T-cell leukemia virus ..
  26. pmc Effects of simian virus 40 large and small tumor antigens on mammalian target of rapamycin signaling: small tumor antigen mediates hypophosphorylation of eIF4E-binding protein 1 late in infection
    Yongjun Yu
    Department of Cancer Biology, Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104 6142, USA
    J Virol 79:6882-9. 2005
    We report that late in a simian virus 40 (SV40) infection in CV-1 cells, there are significant decreases in phosphorylations of two mammalian target of rapamycin (mTOR) signaling effectors, the eIF4E-binding protein (4E-BP1) and p70 S6 ..
  27. pmc Identification of a promoter component involved in positioning the 5' termini of simian virus 40 early mRNAs
    P K Ghosh
    Proc Natl Acad Sci U S A 78:100-4. 1981
    The 5' termini of the principal early mRNAs produced in cells transformed by wild-type simian virus 40 lie 21-25 nucleotides downstream from an A-T-T-T-A-T sequence on the DNA template...
  28. pmc Association of simian virus 40 vp1 with 70-kilodalton heat shock proteins and viral tumor antigens
    Peggy P Li
    Molecular Biology Institute, 456 Boyer Hall, University of California at Los Angeles, 611 East Charles E Young Dr, Box 951570, Los Angeles, CA 90095 1570, USA
    J Virol 83:37-46. 2009
    ..The major capsid protein Vp1 of simian virus 40 forms a series of disulfide-linked intermediates during folding and capsid formation...
  29. ncbi Inhibition of Simian virus 40 large T antigen helicase activity by fluoroquinolones
    Syed Hamid Ali
    Department of Biological and Biomedical Sciences, The Aga Khan University, Karachi, Pakistan
    Antivir Ther 12:1-6. 2007
    ..Inhibition of gyrase activity by quinolones involves the interaction of these drugs with the helicase component of bacterial gyrase. DNA tumour viruses also encode helicases that are essential for their DNA replication in the host...
  30. ncbi Detection of BK virus and simian virus 40 in the urine of healthy children
    John A Vanchiere
    Department of Pediatrics, Section of Infectious Diseases, Baylor College of Medicine, Houston, Texas 77030, USA
    J Med Virol 75:447-54. 2005
    ..We sought to determine if simian virus 40 (SV40) excretion could be detected in the urine of healthy children and to define the age-related prevalence ..
  31. ncbi Clonal chromosomal aberrations in simian virus 40-transfected human thyroid cells and in derived tumors developed after in vitro irradiation
    H Zitzelsberger
    Institute of Radiobiology, GSF Forschungszentrum für Umwelt und Gesundheit GmbH, Neuherberg, Germany
    Int J Cancer 96:166-77. 2001
    ..A number of chromosomal aberrations were found to be characteristic for simian virus 40 immortalization and/or radiation-induced transformation of human thyroid epithelial cells...
  32. pmc Simian virus 40 Vp1 DNA-binding domain is functionally separable from the overlapping nuclear localization signal and is required for effective virion formation and full viability
    P P Li
    Department of Molecular, Cell and Developmental Biology and Molecular Biology Institute, University of California at Los Angeles, Los Angeles, California 90095, USA
    J Virol 75:7321-9. 2001
    A DNA-binding domain (DBD) was identified on simian virus 40 (SV40) major capsid protein Vp1, and the domain's function in the SV40 life cycle was examined...
  33. ncbi Caveolin-stabilized membrane domains as multifunctional transport and sorting devices in endocytic membrane traffic
    Lucas Pelkmans
    Max Planck Institute for Molecular Cell Biology and Genetics, 01307 Dresden, Germany
    Cell 118:767-80. 2004
    ..Following transport of the caveolar protein Caveolin-1 and two cargo complexes, Simian Virus 40 and Cholera toxin, in live cells, we uncovered a Rab5-dependent pathway in which caveolar vesicles are ..
  34. pmc Activation of the tumor-specific death effector apoptin and its kinase by an N-terminal determinant of simian virus 40 large T antigen
    Ying Hui Zhang
    Leadd B V, Leiden, The Netherlands
    J Virol 78:9965-76. 2004
    ..cells apoptin can also be activated by the transient transforming signals conferred by ectopically expressed simian virus 40 (SV40) large T antigen (LT), which rapidly induces apoptin's phosphorylation, nuclear accumulation, and the ..
  35. ncbi SV40 and human tumours: myth, association or causality?
    Adi F Gazdar
    Hamon Center for Therapeutic Oncology Research and Department of Pathology, University of Texas Southwestern Medical Centre, Dallas, Texas 75390, USA
    Nat Rev Cancer 2:957-64. 2002
    An increasing number of scientific reports have described evidence for a polyomavirus, simian virus 40, in a highly select group of human tumours...
  36. ncbi Exploitation of major histocompatibility complex class I molecules and caveolae by simian virus 40
    R G Parton
    Department of Physiology and Pharmacology, University of Queensland, Brisbane, Australia
    Immunol Rev 168:23-31. 1999
    b>Simian virus 40 (SV40), a non-enveloped DNA virus, is transported from the cell surface to the nucleus where virus replication occurs...
  37. ncbi Absence of Epstein-Barr virus, human papillomavirus, and simian virus 40 in patients of central european origin with lymphoepithelioma-like carcinoma of the skin
    Dmitry V Kazakov
    Sikl s Department of Pathology, Charles University, Medical Faculty Hospital, Pilsen, Czech Republic
    Am J Dermatopathol 29:365-9. 2007
    ..Because all 10 cases studied proved negative for EBV, HPV, and SV40, these viruses seem to play no causal role in LELC of the skin in patients from Central Europe...
  38. ncbi Cancer risk associated with receipt of vaccines contaminated with simian virus 40: epidemiologic research
    Eric A Engels
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, DHHS, 6120 Executive Blvd, EPS 8010 Rockville, MD 20892, USA
    Expert Rev Vaccines 4:197-206. 2005
    ....
  39. ncbi Maximum-likelihood multi-reference refinement for electron microscopy images
    Sjors H W Scheres
    Biocomputing Unit, Centro Nacional de Biotecnologia, Campus Universidad Autonoma, Cantoblanco, 28049, Madrid, Spain
    J Mol Biol 348:139-49. 2005
    ..of this approach to a cryo-electron microscopy dataset revealed two major classes for projections of simian virus 40 large T-antigen in complex with an asymmetric DNA-probe, containing the origin of simian virus 40 replication...
  40. ncbi Secrets of caveolae- and lipid raft-mediated endocytosis revealed by mammalian viruses
    Lucas Pelkmans
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
    Biochim Biophys Acta 1746:295-304. 2005
    ..Again, viruses are proving to be excellent tools to reach that goal...
  41. pmc Stat3 is required for full neoplastic transformation by the Simian Virus 40 large tumor antigen
    Adina Vultur
    Department of Microbiology and Immunology, Queen s University, Kingston, Ontario K7L 3N6, Canada
    Mol Biol Cell 16:3832-46. 2005
    ..transducer and activator of transcription-3) in neoplastic transformation by the Large Tumor antigen of Simian Virus 40 (TAg), murine fibroblasts were rendered deficient in Stat3 activity through expression of a Stat3-specific ..
  42. pmc Histone hyperacetylation in the coding region of chromatin undergoing transcription in SV40 minichromosomes is a dynamic process regulated directly by the presence of RNA polymerase II
    Lata Balakrishnan
    Department of Biochemistry and Molecular Biology, University of North Dakota, Grand Forks, ND 58203, USA
    J Mol Biol 365:18-30. 2007
    ....
  43. pmc The T/t common exon of simian virus 40, JC, and BK polyomavirus T antigens can functionally replace the J-domain of the Escherichia coli DnaJ molecular chaperone
    W L Kelley
    Departement de Biochimie Medicale, Centre Medical Universitaire, Universite de Geneve, Geneva, Switzerland
    Proc Natl Acad Sci U S A 94:3679-84. 1997
    ..yet significant, amino acid sequence homology to the J-domain, the DNA encoding the T/t common exon of the simian virus 40 (SV40), JC, or BK polyoma virus T antigen oncoproteins was used to construct J-domain replacement chimeras of ..
  44. pmc Cell-type specific regulation of gene expression by simian virus 40 T antigens
    Paul G Cantalupo
    Department of Biological Sciences, 559 Crawford Hall, University of Pittsburgh Pittsburgh, Pennsylvania 15260, USA
    Virology 386:183-91. 2009
    ....
  45. pmc Crocidolite asbestos and SV40 are cocarcinogens in human mesothelial cells and in causing mesothelioma in hamsters
    Barbara Kroczynska
    Thoracic Oncology Program, Cardinal Bernardin Cancer Center, Loyola University Chicago, Maywood, IL 60153, USA
    Proc Natl Acad Sci U S A 103:14128-33. 2006
    ..Our results indicate that mineral fibers and viruses can be cocarcinogens and suggest that lower amounts of asbestos may be sufficient to cause MM in individuals infected with SV40...
  46. pmc Cell penetration and trafficking of polyomavirus
    Joanna M Gilbert
    Department of Pathology, Harvard Medical School, 200 Longwood Avenue, Armenise 233, Boston, MA 02115, USA
    J Virol 77:2615-22. 2003
    ..In contrast, uptake of simian virus 40 into the same cells is dependent on caveola...
  47. pmc Enumeration of the simian virus 40 early region elements necessary for human cell transformation
    William C Hahn
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
    Mol Cell Biol 22:2111-23. 2002
    ..We recently reported that coexpression of the simian virus 40 (SV40) early region (ER), the gene encoding the telomerase catalytic subunit (hTERT), and an oncogenic allele ..
  48. pmc A large and intact viral particle penetrates the endoplasmic reticulum membrane to reach the cytosol
    Takamasa Inoue
    Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America
    PLoS Pathog 7:e1002037. 2011
    ..They also suggest that the ER membrane supports passage of a large particle, potentially through either a sizeable protein-conducting channel or the lipid bilayer...
  49. ncbi Ataxia-telangiectasia-mutated (ATM) is a T-antigen kinase that controls SV40 viral replication in vivo
    Yuling Shi
    Department of Pharmacology, University of Wisconsin Medical School, Madison, Wisconsin 53706, USA
    J Biol Chem 280:40195-200. 2005
    ..Our findings uncover a direct link between ATM and SV40 LTag that may have implications for understanding the replication cycle of oncogenic polyoma viruses...
  50. pmc Association with capsid proteins promotes nuclear targeting of simian virus 40 DNA
    A Nakanishi
    Department of Molecular, Cell, and Developmental Biology, University of California, Los Angeles 90095, USA
    Proc Natl Acad Sci U S A 93:96-100. 1996
    ..The role of capsid proteins in nuclear targeting of simian virus 40 (SV40) DNA, which is assessed by the nuclear accumulation of large tumor (T) antigen, the initial sign of the ..
  51. pmc A very late viral protein triggers the lytic release of SV40
    Robert Daniels
    Department of Biochemistry and Molecular Biology, University of Massachusetts, Amherst, Massachusetts, United States of America
    PLoS Pathog 3:e98. 2007
    How nonenveloped viruses such as simian virus 40 (SV40) trigger the lytic release of their progeny is poorly understood...
  52. pmc Sequence requirements for plasmid nuclear import
    D A Dean
    College of Medicine, University of South Alabama, Mobile, Alabama 36688, USA
    Exp Cell Res 253:713-22. 1999
    ..Thus, the inclusion this SV40 sequence in nonviral vectors may greatly increase their ability to be transported into the nucleus, especially in nondividing cells...
  53. ncbi A role of the TATA box and the general co-activator hTAF(II)130/135 in promoter-specific trans-activation by simian virus 40 small t antigen
    Mona Johannessen
    Department of Biochemistry, Section for Molecular Genetics, Institute of Medical Biology, University of Tromsø, N 9037 Tromsø, Norway
    J Gen Virol 84:1887-97. 2003
    The small t antigen (st-ag) of simian virus 40 can exert pleiotropic effects on biological processes such as DNA replication, cell cycle progression and gene expression...
  54. ncbi Simian virus 40 induces multiple S phases with the majority of viral DNA replication in the G2 and second S phase in CV-1 cells
    J M Lehman
    Department of Microbiology, Immunology, and Molecular Genetics, Center for Immunology and Microbial Diseases, Albany Medical College, New York 12208, USA
    Exp Cell Res 258:215-22. 2000
    The infection of permissive monkey kidney cells (CV-1) with simian virus 40 induces G1 growth-arrested cells into the cell cycle...
  55. pmc Importance of Vp1 calcium-binding residues in assembly, cell entry, and nuclear entry of simian virus 40
    Peggy P Li
    Department of Molecular, Cell and Developmental Biology and Molecular Biology Institute, University of California at Los Angeles, Los Angeles, California 90095, USA
    J Virol 77:7527-38. 2003
    ..To define the role of calcium ions in the life cycle of the virus, we analyzed simian virus 40 (SV40) mutants in which structurally deduced calcium-binding amino acids of Vp1 were mutated singly and in ..
  56. ncbi Parafibromin tumor suppressor enhances cell growth in the cells expressing SV40 large T antigen
    T Iwata
    Department of Medical Pharmacology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan
    Oncogene 26:6176-83. 2007
    ..The tumor suppressor protein PF acts as a positive regulator of cell growth similar to an oncoprotein in the presence of SV40 large T antigen...
  57. pmc Simian virus 40 transformation, malignant mesothelioma and brain tumors
    Fang Qi
    University of Hawaii Cancer Center, Honolulu, HI, USA
    Expert Rev Respir Med 5:683-97. 2011
    b>Simian virus 40 (SV40) is a DNA virus isolated in 1960 from contaminated polio vaccines, that induces mesotheliomas, lymphomas, brain and bone tumors, and sarcomas, including osteosarcomas, in hamsters...
  58. pmc Enforced expression of Simian virus 40 large T-antigen leads to testicular germ cell tumors in zebrafish
    James A Gill
    Genetics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20889, USA
    Zebrafish 7:333-41. 2010
    ..promoter, which has been shown to enforce high-level expression in the testes of transgenic mice, to express Simian virus 40 large T-antigen in zebrafish testes...
  59. pmc Mutations in the GM1 binding site of simian virus 40 VP1 alter receptor usage and cell tropism
    Thomas G Magaldi
    Department of Genetics, Yale School of Medicine, New Haven, Connecticut, USA
    J Virol 86:7028-42. 2012
    ..receptor specificity and how changes in receptor usage affect tropism, we studied the primate polyomavirus simian virus 40 (SV40), which uses the ganglioside GM1 as a receptor that mediates cell binding and entry...
  60. ncbi Molecular pathogenesis of malignant mesothelioma and its relationship to simian virus 40
    Adi F Gazdar
    Hamon Center for Therapeutic Oncology Research and Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Clin Lung Cancer 5:177-81. 2003
    ..The molecular changes caused by each of these major etiologic factors and their interrelationships are the focus of this review...
  61. ncbi Local actin polymerization and dynamin recruitment in SV40-induced internalization of caveolae
    Lucas Pelkmans
    Swiss Federal Institute of Technology Zurich ETHZ, HPM1 Building, ETH Honggerberg, CH 8093 Zurich, Switzerland
    Science 296:535-9. 2002
    b>Simian virus 40 (SV40) utilizes endocytosis through caveolae for infectious entry into host cells. We found that after binding to caveolae, virus particles induced transient breakdown of actin stress fibers...
  62. pmc Patterns of polyomavirus SV40 infections and associated cancers in humans: a model
    Janet S Butel
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA
    Curr Opin Virol 2:508-14. 2012
    ..This model can explain inconsistencies in the published literature of SV40 infections in humans and can guide the design of future studies...
  63. ncbi SV40, growth factors, and mesothelioma: another piece of the puzzle
    Brooke T Mossman
    Departments of Pathology and Medicine, University of Vermont College of Medicine, Burlington, VT 05405, USA
    Am J Respir Cell Mol Biol 26:167-70. 2002
  64. doi Simian virus 40 large T-antigen G-quadruplex DNA helicase inhibition by G-quadruplex DNA-interactive agents
    Bodin Tuesuwan
    Division of Medicinal Chemistry, College of Pharmacy, The University of Texas at Austin, Austin, Texas 78712, USA
    Biochemistry 47:1896-909. 2008
    ..The identification of potent and selective inhibitors of the G-quadruplex helicase activity of T-ag provides tools for probing the specific role of this activity in SV40 replication...
  65. doi Investigation of the prevalence of antibodies against neurotropic polyomaviruses BK, JC and SV40 in sera from patients affected by multiple sclerosis
    Tatiana Ribeiro
    INSERM U618 Proteases et Vectorisation Pulmonaires, Tours, University Francois Rabelais, Tours, France
    Neurol Sci 31:517-21. 2010
    ....
  66. ncbi The carboxyl-terminal domain of large T antigen rescues SV40 host range activity in trans independent of acetylation
    Danielle L Poulin
    Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Virology 349:212-21. 2006
    ..The carboxyl-terminal region of T Ag contains a biological function essential for the SV40 viral life cycle...
  67. pmc Bidirectional DNA unwinding by a ternary complex of T antigen, nucleolin and topoisomerase I
    Stephanie Seinsoth
    Medizinische Biochemie und Molekularbiologie, Universitat des Saarlandes, Gebaude 45, D 66421 Homburg, Germany
    EMBO Rep 4:263-8. 2003
    The simian virus 40 large tumour-antigen (T antigen) DNA helicase is a hexameric structure; it has been proposed that, in viral DNA replication, two of these hexamers are combined to form a bipartite holoenzyme that acts concurrently at ..
  68. ncbi Simian virus 40 VP1 capsid protein forms polymorphic assemblies in vitro
    Shin nosuke Kanesashi
    Faculty of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259 Nagatsuta, Midori ku, Yokohama 226 8503, Japan
    J Gen Virol 84:1899-905. 2003
    The simian virus 40 (SV40) capsid is composed of 72 pentamers of VP1, the major protein of SV40...
  69. pmc Development of quantitative and high-throughput assays of polyomavirus and papillomavirus DNA replication
    Amelie Fradet-Turcotte
    Laboratory of Molecular Virology, Institut de recherches cliniques de Montreal IRCM, Montreal, Quebec, Canada
    Virology 399:65-76. 2010
    ..These quantitative and high-throughput assays should greatly facilitate the study of SV40 and HPV31 DNA replication and the identification of small-molecule inhibitors of this process...
  70. pmc Pairs of Vp1 cysteine residues essential for simian virus 40 infection
    Peggy P Li
    Molecular Biology Institute, 456 Boyer Hall, University of California at Los Angeles, 611 East Charles E Young Dr, Box 951570, Los Angeles, CA 90095 1570, USA
    J Virol 79:3859-64. 2005
    Transient disulfide bonding occurs during the intracellular folding and pentamerization of simian virus 40 (SV40) major capsid protein Vp1 (P. P. Li, A. Nakanishi, S. W. Clark, and H. Kasamatsu, Proc. Natl. Acad. Sci...
  71. ncbi CD4+ T lymphocytes play a critical role in antibody production and tumor immunity against simian virus 40 large tumor antigen
    Ronald C Kennedy
    Department of Microbiology and Immunology, Texas Tech University Health Science Center, Lubbock, Texas 79430, USA
    Cancer Res 63:1040-5. 2003
    ..Our results suggest that CD4+ T cells, along with antibody responses, play a role in the induction of tumor immunity to a viral-encoded tumor antigen...
  72. pmc Mutagenesis of a functional chimeric gene in yeast identifies mutations in the simian virus 40 large T antigen J domain
    Sheara W Fewell
    Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Proc Natl Acad Sci U S A 99:2002-7. 2002
    b>Simian virus 40 large T antigen contains an amino terminal J domain that catalyzes T antigen-mediated viral DNA replication and cellular transformation...
  73. pmc 19S late mRNAs of simian virus 40 have an internal ribosome entry site upstream of the virion structural protein 3 coding sequence
    Yongjun Yu
    Department of Cancer Biology, Abramson Family Cancer Research Institute, 314 Biomedical Research Building, 421 Curie Blvd, University of Pennsylvania, Philadelphia, PA 19104 6142, USA
    J Virol 80:6553-8. 2006
    The late mRNAs of simian virus 40 (SV40) are polycistronic. The 19S mRNAs encode primarily the virion structural proteins VP2 and VP3...
  74. pmc Gangliosides are receptors for murine polyoma virus and SV40
    Billy Tsai
    Howard Hughes Medical Institute and Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
    EMBO J 22:4346-55. 2003
    Polyoma virus (Py) and simian virus 40 (SV40) travel from the plasma membrane to the endoplasmic reticulum (ER) from where they enter the cytosol and then the nucleus to initiate infection...
  75. pmc Productive simian virus 40 infection of neurons in immunosuppressed Rhesus monkeys
    Xin Dang
    Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Neuropathol Exp Neurol 67:784-92. 2008
    ..Reactivation of simian virus 40 (SV40) in immunosuppressed rhesus monkeys, however, rarely causes a PML-like illness...
  76. ncbi Bucillamine induces the synthesis of vascular endothelial growth factor dose-dependently in systemic sclerosis fibroblasts via nuclear factor-kappaB and simian virus 40 promoter factor 1 pathways
    Jörg H W Distler
    Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland
    Mol Pharmacol 65:389-99. 2004
    ..The study provides evidence for a role of NF-kappaB in the transcriptional regulation of the VEGF gene. SA 96 might have positive aspects on the impaired angiogenesis in patients with SSc...
  77. pmc Disassembly of simian virus 40 during passage through the endoplasmic reticulum and in the cytoplasm
    Dmitry Kuksin
    Department of Microbiology, University of Massachusetts, Amherst, Massachusetts, USA
    J Virol 86:1555-62. 2012
    The nonenveloped polyomavirus simian virus 40 (SV40) is taken up into cells by a caveola-mediated endocytic process that delivers the virus to the endoplasmic reticulum (ER)...
  78. ncbi Immortalization of swine umbilical vein endothelial cells (SUVECs) with the simian virus 40 large-T antigen
    Marcin Chruściel
    Department of Hormonal Action Mechanisms, Institute of Animal Reproduction and Food Research, Polish Academy of Science, Olsztyn, Poland
    Mol Reprod Dev 78:597-610. 2011
    ..We have generated an immortalized endothelial cell line, G-1410, using Simian virus 40 T-antigen (SV40 T-ag) primarily to overcome the short life span before the onset of senescence and high ..
  79. ncbi Mammalian DNA topoisomerase I activity and poisoning by camptothecin are inhibited by simian virus 40 large T antigen
    Y Pommier
    Laboratory of Molecular Pharmacology, National Cancer Institute, Bethesda, Maryland 20892 4255, USA
    Biochemistry 37:3818-23. 1998
    ..These results demonstrate a functional interaction between T-Ag and top1: they also suggest the importance of top1-protein interactions for the regulation of DNA replication and modulation of camptothecin activity...
  80. ncbi Presence of simian virus 40 DNA sequences in diffuse large B-cell lymphomas in Tunisia correlates with aberrant promoter hypermethylation of multiple tumor suppressor genes
    Khaled Amara
    Laboratory of Pathology, CHU Farhat Hached, Sousse, Tunisia
    Int J Cancer 121:2693-702. 2007
    ..The significant association of promoter hypermethylation of multiple TSGs with the presence of SV40 DNA in DLBCLs supports a functional effect of the virus in those lymphomas...
  81. doi The relationship between simian virus 40 and mesothelioma
    Zeyana Rivera
    Cancer Research Center of Hawaii and Department of Pathology, University of Hawaii, Honolulu, Hawaii, USA
    Curr Opin Pulm Med 14:316-21. 2008
    b>Simian virus 40 is present in some human malignant mesotheliomas. The evidence in favor and against a pathogenic role of simian virus 40 in malignant mesothelioma is discussed in this review.
  82. ncbi Establishment and partial characterization of an ovine synovial membrane cell line obtained by transformation with Simian Virus 40 T antigen
    U M Costa
    Departamento de Patologia Clinica Veterinaria, Faculdade de Veterinaria, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil
    J Virol Methods 128:72-8. 2005
    ..Finally, the transformed ovine synovial membrane cells were shown to be permissive to small ruminant lentiviruses, and these are suggested as a cell line for in vitro isolation and propagation of these viruses...
  83. pmc Cul7/p185/p193 binding to simian virus 40 large T antigen has a role in cellular transformation
    Syed Hamid Ali
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    J Virol 78:2749-57. 2004
    b>Simian virus 40 large T antigen (TAg) is a viral oncoprotein that can promote cellular transformation...
  84. pmc Efficient delivery of RNA interference effectors via in vitro-packaged SV40 pseudovirions
    Chava Kimchi-Sarfaty
    Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 4256, USA
    Hum Gene Ther 16:1110-5. 2005
    Previously we have shown that in vitro-packaged simian virus 40 (SV40) pseudovirions (IVPs) are an efficient delivery system for supercoiled DNA plasmids of up to 17.7 kb, with or without SV40 sequences...
  85. pmc Intestinal dysplasia induced by simian virus 40 T antigen is independent of p53
    Jennifer A Markovics
    Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA
    J Virol 79:7492-502. 2005
    Transgenic mice expressing simian virus 40 large T antigen in enterocytes develop intestinal hyperplasia that progresses to dysplasia with age...
  86. ncbi Some oral poliovirus vaccines were contaminated with infectious SV40 after 1961
    Rochelle Cutrone
    Thoracic Oncology Program, Cardinal Bernardin Cancer Center, Loyola University, Chicago, Illinois, USA
    Cancer Res 65:10273-9. 2005
    ..Moreover, our results indicate possible geographic differences in SV40 exposure and offer a possible explanation for the different percentage of SV40-positive tumors detected in some laboratories...
  87. ncbi Identification of the SV40 agnogene product: a DNA binding protein
    G Jay
    Nature 291:346-9. 1981
  88. ncbi Absence of SV40 and other polyomavirus (JCV, BKV) DNA in primary cutaneous B cell lymphomas
    Sylke Gellrich
    J Invest Dermatol 124:278-9. 2005
  89. ncbi The binding of topoisomerase I to T antigen enhances the synthesis of RNA-DNA primers during simian virus 40 DNA replication
    Sujata Khopde
    Department of Biological Sciences, University of Delaware, Newark, Delaware 19716 2590, USA
    Biochemistry 47:9653-60. 2008
    Topoisomerase I (topo I) is required for the proper initiation of simian virus 40 (SV40) DNA replication...
  90. ncbi The role of insulin receptor substrate-1 in the oncogenicity of simian virus 40 T antigen
    An Wu
    Thomas Jefferson University, Department of Cancer Biology, Kimmel Cancer Center, Philadelphia, Pennsylvania 19107, USA
    Cell Cycle 7:1999-2002. 2008
    The Simian Virus 40 large T antigen (Tag) and the insulin receptor substrate-1 (IRS-1) interact with each other...
  91. pmc The simian virus 40 minimal origin and the 72-base-pair repeat are required simultaneously for efficient induction of late gene expression with large tumor antigen
    S W Hartzell
    Proc Natl Acad Sci U S A 81:6335-9. 1984
    We have studied the temporal regulation of simian virus 40 (SV40) late gene expression by construction and transient expression analysis of plasmids containing the transposon Tn9 chloramphenicol acetyltransferase gene placed downstream ..
  92. pmc Mutational analysis of simian virus 40 T antigen: isolation and characterization of mutants with deletions in the T-antigen gene
    J M Pipas
    Mol Cell Biol 3:203-13. 1983
    A series of mutants of simian virus 40 has been constructed with deletions in the coding sequence for large T antigen. Nucleotide sequence analysis indicates that 4 mutants have in-phase and 11 have out-of-phase deletions...
  93. pmc Wild-type p53 enhances efficiency of simian virus 40 large-T-antigen-induced cellular transformation
    Andrea Hermannstädter
    Heinrich Pette Institute for Experimental Virology and Immunology Martinistr 52, D 20251 Hamburg, Germany
    J Virol 83:10106-18. 2009
    ..infection of BALB/c mouse embryo fibroblasts differing in p53 gene status (p53(+/+) versus p53(-/)(-)) with simian virus 40 (SV40) revealed a quantitatively and qualitatively decreased transformation efficiency in p53(-/-) cells ..
  94. ncbi Complete enzymatic synthesis of DNA containing the SV40 origin of replication
    Y Ishimi
    Memorial Sloan Kettering Cancer Center, Graduate Program in Molecular Biology, New York, New York 10021
    J Biol Chem 263:19723-33. 1988
    The replication of simian virus 40 origin-containing DNA has been reconstituted in vitro with SV40 large T antigen and purified proteins isolated from HeLa cells...
  95. ncbi High levels of luteinizing hormone analog stimulate gonadal and adrenal tumorigenesis in mice transgenic for the mouse inhibin-alpha-subunit promoter/Simian virus 40 T-antigen fusion gene
    Maarit Mikola
    Department of Physiology, University of Turku, FIN 20520 Turku, Finland
    Oncogene 22:3269-78. 2003
    Transgenic (TG) mice expressing the Simian virus 40 T-antigen under the control of the murine inhibin-alpha promoter (Inhalpha/Tag) develop granulosa and Leydig cell tumors at the age of 5-6 months, with 100% penetrance...
  96. ncbi Overexpression of diacylglycerol acyltransferase-1 reduces phospholipid synthesis, proliferation, and invasiveness in simian virus 40-transformed human lung fibroblasts
    Carolina Bagnato
    Instituto de Investigaciones Bioquímicas de La Plata INIBIOLP, CONICET UNLP, Facultad de Ciencias Medicas, Universidad Nacional de La Plata, calles 60 y 120, 1900 La Plata, Argentina
    J Biol Chem 278:52203-11. 2003
    ..These results strongly support the view that DGAT participates in the regulation of membrane lipid synthesis and lipid signaling, thereby playing an important role in modulating cell growth properties...
  97. ncbi In vitro assessment of the cytotoxicity of nisin, pediocin, and selected colicins on simian virus 40-transfected human colon and Vero monkey kidney cells with trypan blue staining viability assays
    S E Murinda
    Department of Food Science, Pennsylvania State University, University Park, Pennsylvania 16802, USA
    J Food Prot 66:847-53. 2003
    ..bacteriocins (colicins [Col] E1, E3, E6, E7, and K) were evaluated for cytotoxicity against cultured simian virus 40-transfected human colon (SV40-HC) and Vero monkey kidney (Vero) cells...
  98. ncbi Targeting CCR5 with siRNAs: using recombinant SV40-derived vectors to protect macrophages and microglia from R5-tropic HIV
    Pierre Cordelier
    Department of Pathology and Cell Biology, Jefferson Medical College, Philadelphia, PA 19107, USA
    Oligonucleotides 13:281-94. 2003
    ..Therefore, strategies to target CCR5 using rSV40-delivered, VA promoter-driven siRNAs may be useful therapeutic options for treating HIV infection...
  99. ncbi Long-term controlled immortalization of a primate hepatic progenitor cell line after Simian virus 40 T-Antigen gene transfer
    Jean Paul Delgado
    INSERM EMI 00 20 University Paris XI, Hôpital Kremlin Bicêtre, 80 avenue du Général Leclerc, 94276 Kremlin Bicêtre, France
    Oncogene 24:541-51. 2005
    ..we describe the long-term behaviour of a clone of simian foetal hepatic progenitor cells immortalized by Simian virus 40 (SV40) large T-antigen (T-Ag) flanked by loxP sites...
  100. ncbi SV40 17KT antigen complements dnaj mutations in large T antigen to restore transformation of primary human fibroblasts
    Anita Boyapati
    Department of Microbiology Immunology and The Robert H Lurie Comprehensive Cancer Center, Northwestern University, 303 E Chicago Avenue, Chicago, IL 60611, USA
    Virology 315:148-58. 2003
    ..Similar to large T, this protein reduces levels of the retinoblastoma-related protein, p130, and stimulates cell-cycle progression of quiescent fibroblasts, two activities of large T that are disrupted by dnaJ mutations...
  101. pmc SV40 Tag DNA sequences, present in a small proportion of human hepatocellular carcinomas, are associated with reduced survival
    N A C S Wong
    Department of Pathology, University of Edinburgh Medical School, Edinburgh EH8 9AG, UK
    J Clin Pathol 56:904-9. 2003
    To study the association between simian virus 40 (SV40) and human hepatocarcinogenesis.

Research Grants72

  1. VIRAL REGULATION OF RIBOSOMAL RNA TRANSCRIPTION
    Lucio Comai; Fiscal Year: 2002
    DESCRIPTION (adapted from the applicant's abstract): Simian virus 40 (SV40) large T antigen is a multifunctional regulatory protein that plays a key role in the viral life cycle...
  2. MICROSCOPY & IMAGE ANALYSIS OF UNSTAINED MACROMOLECULES
    Timothy Baker; Fiscal Year: 1992
    ..These include members of the Papovaviridae (polyoma virus, simian virus 40, and bovine, human, and cottontail rabbit papilloma viruses), the Reoviridae (rhesus rotavirus and serotype-1 ..
  3. MICROSCOPY & IMAGE ANALYSIS OF UNSTAINED MACROMOLECULES
    Timothy Baker; Fiscal Year: 1993
    ..These include members of the Papovaviridae (polyoma virus, simian virus 40, and bovine, human, and cottontail rabbit papilloma viruses), the Reoviridae (rhesus rotavirus and serotype-1 ..
  4. Simian Virus 40 (SV40) uncoating and penetration
    Daniel Hebert; Fiscal Year: 2009
    ..goal of the proposal is to elucidate the mechanism of viral uncoating for nonenveloped DNA viruses using Simian Virus 40 (SV40) as a model virus. Viruses replicate within living cells by exploiting the host cellular machinery...
  5. INTRACELLULAR MECHANISMS OF GLUCOCORTICOID ACTION
    Donald Defranco; Fiscal Year: 1999
    ..shown to be required for the in vivo and in vitro nuclear import of various karyophilic proteins, such as the simian virus 40 large tumor antigen (SV40 TAg)...
  6. A chemical genetic approach to inhibiting T-ag assembly on the viral origin
    Peter Bullock; Fiscal Year: 2007
    ..will be searched for members that are able to disrupt the assembly of a prototype viral initiator termed Simian Virus 40 T-antigen...
  7. Pathogenesis of mesothelioma
    Michele Carbone; Fiscal Year: 2006
    ..Cigarette smoke has been ruled out as a co-factor in MM. Instead, both genetic predisposition and simian virus 40 infections (SV40) have been linked to MM pathogenesis...
  8. Pathogenesis of mesothelioma
    Michele Carbone; Fiscal Year: 2007
    ..Cigarette smoke has been ruled out as a co-factor in MM. Instead, both genetic predisposition and simian virus 40 infections (SV40) have been linked to MM pathogenesis...
  9. Pathogenesis of mesothelioma
    Michele Carbone; Fiscal Year: 2009
    ..Cigarette smoke has been ruled out as a co-factor in MM. Instead, both genetic predisposition and simian virus 40 infections (SV40) have been linked to MM pathogenesis...
  10. Pathogenesis of mesothelioma
    Michele Carbone; Fiscal Year: 2010
    ..Cigarette smoke has been ruled out as a co-factor in MM. Instead, both genetic predisposition and simian virus 40 infections (SV40) have been linked to MM pathogenesis...
  11. HTLV-III SEQUENCES AT THE TRANSCRIPTIONAL LEVEL
    JOSEPH MOSCA; Fiscal Year: 1990
    ....
  12. SV40 T ANTIGEN TRANSACTIVATION AND TRANSFORMATION
    JANE CAVENDER; Fiscal Year: 2000
    DESCRIPTION: (Adapted from the Investigator's abstract): Simian Virus 40 T antigen has been used extensively to elucidate the functions needed to transform cells in culture...
  13. MECHANISMS OF POLYADENYLATION IN VIRAL SYSTEMS
    JAMES ALWINE; Fiscal Year: 1993
    ..The simian virus 40 (SV40) late polyadenylation signal has these elements; however, we have found that it functions efficiently ..
  14. MECHANISMS OF POLYADENYLATION IN VIRAL SYSTEMS
    JAMES ALWINE; Fiscal Year: 1992
    ..The simian virus 40 (SV40) late polyadenylation signal has these elements; however, we have found that it functions efficiently ..
  15. MECHANISMS OF POLYADENYLATION IN VIRAL SYSTEMS
    JAMES ALWINE; Fiscal Year: 1991
    ..The simian virus 40 (SV40) late polyadenylation signal has these elements; however, we have found that it functions efficiently ..
  16. HUMAN CANCER--ORIGIN AND GENETIC MARKERS
    PHILIP FIALKOW; Fiscal Year: 1993
    ..5) To document the suggestions that Simian virus 40 (SV40)-transformed marrow stromal ("microenvironmental") cells in long-term marrow cultures can be grown as ..
  17. MECHANISMS OF NUCLEAR PROTEIN ACCUMULATION
    PHILIP PAINE; Fiscal Year: 1993
    ..study the nucleocytoplasmic transport of (i) two widely-studied prototype N- proteins, nucleoplasmic and the simian virus 40 large T antigen (SV40 lg T), and (ii) macromolecular dextrans with covalently attached signal sequences of ..
  18. Hyperacetylation of Biologically Active SV40 Chromatin
    Barry Milavetz; Fiscal Year: 2006
    unreadable] DESCRIPTION (provided by applicant): Using simian virus 40 (SV40) as a model for infections by DNA viruses, the proposed research will contribute to our understanding of the relationship between chromatin remodeling through ..
  19. REGULATION OF DNA TUMOR VIRUS GENE EXPRESSION
    JAMES ALWINE; Fiscal Year: 2000
    b>Simian virus 40 large T antigen is a promiscuous activator of many viral and cellular promoters...
  20. REGULATION OF DNA TUMOR VIRUS GENE EXPRESSION
    JAMES ALWINE; Fiscal Year: 1999
    b>Simian virus 40 large T antigen is a promiscuous activator of many viral and cellular promoters...
  21. Role of Fra-1 in Mesothelioma
    Maria Ramos Nino; Fiscal Year: 2006
    ..an aggressive malignancy associated with occupational exposure to asbestos and more recently linked to Simian Virus 40 (SV40) is a fatal tumor resistant to therapy...
  22. Role of Fra-1 in Mesothelioma
    Maria Ramos Nino; Fiscal Year: 2005
    ..an aggressive malignancy associated with occupational exposure to asbestos and more recently linked to Simian Virus 40 (SV40) is a fatal tumor resistant to therapy...
  23. Use of SV40 derived vectors to inhibit HIV 1 infection
    David Strayer; Fiscal Year: 2000
    ..abstract_text> ..
  24. SV 40 DNA REPLICATION
    Bruce Stillman; Fiscal Year: 1999
    ..Towards this goal, the mechanism of DNA replication from the Simian Virus 40 (SV40) and the bovine papillomavirus (BPV) origins of DNA replication will be investigated...
  25. SV 40 DNA REPLICATION
    Bruce Stillman; Fiscal Year: 2001
    ..Towards this goal, the mechanism of DNA replication from the Simian Virus 40 (SV40) and the bovine papillomavirus (BPV) origins of DNA replication will be investigated...
  26. Role of Fra-1 in Mesothelioma
    Maria Ramos Nino; Fiscal Year: 2004
    ..an aggressive malignancy associated with occupational exposure to asbestos and more recently linked to Simian Virus 40 (SV40) is a fatal tumor resistant to therapy...
  27. SV 40 DNA REPLICATION
    Bruce Stillman; Fiscal Year: 2000
    ..Towards this goal, the mechanism of DNA replication from the Simian Virus 40 (SV40) and the bovine papillomavirus (BPV) origins of DNA replication will be investigated...
  28. HPV DNA REPLICATION: NOVEL HOST FACTORS
    Thomas Melendy; Fiscal Year: 2002
    ..Bruce Stillman studying simian virus 40 (SV40) DNA replication factors and mechanisms. Dr...
  29. HPV DNA REPLICATION--NOVEL HOST FACTORS
    Thomas Melendy; Fiscal Year: 1999
    ..Bruce Stillman studying simian virus 40 (SV40) DNA replication factors and mechanisms. Dr...
  30. HPV DNA REPLICATION: NOVEL HOST FACTORS
    Thomas Melendy; Fiscal Year: 2003
    ..Bruce Stillman studying simian virus 40 (SV40) DNA replication factors and mechanisms. Dr...
  31. HPV DNA REPLICATION: NOVEL HOST FACTORS
    Thomas Melendy; Fiscal Year: 2000
    ..Bruce Stillman studying simian virus 40 (SV40) DNA replication factors and mechanisms. Dr...
  32. HPV DNA REPLICATION: NOVEL HOST FACTORS
    Thomas Melendy; Fiscal Year: 2001
    ..Bruce Stillman studying simian virus 40 (SV40) DNA replication factors and mechanisms. Dr...
  33. PATHOLOGY OF NEOPLASTIC TRANSFORMATION
    JOHN LEHMAN; Fiscal Year: 1980
    This proposal will continue the analysis of the mechanism of transformation with the papovavirus, Simian virus 40. We have shown that the stem cell (embryonal carcinoma) of the teratocarcinoma, when infected with SV40 or polyoma virus, ..
  34. REGULATION OF CREB/ATF FUNCTION BY PROTEIN PHOSPHATASES
    Dwight Klemm; Fiscal Year: 1993
    ..Additional preliminary evidence indicates that the small-t antigen of Simian Virus 40 (SV40) may enhance the dephosphorylation of CREB by PP2A...
  35. AIDS-assoc Progressive Multifocal Leukoencephalopathy
    Igor Koralnik; Fiscal Year: 2003
    ..Due to the narrow host range of JCV, there is no adequate animal model for its study. The Simian Virus 40 (SV40) has 69% homology with JCV, and has been associated with a PML like disease in immunosuppressed monkeys...
  36. AIDS-assoc Progressive Multifocal Leukoencephalopathy
    Igor Koralnik; Fiscal Year: 2004
    ..Due to the narrow host range of JCV, there is no adequate animal model for its study. The Simian Virus 40 (SV40) has 69% homology with JCV, and has been associated with a PML like disease in immunosuppressed monkeys...
  37. T-antigen Binding to the Merkel Cell Carcinoma Virus Origin
    ALEX ANDREW BOHM; Fiscal Year: 2010
    ..is significantly different from that of better studied family members such as murine polyomavirus and simian virus 40 (SV40)...
  38. T-antigen Binding to the Merkel Cell Carcinoma Virus Origin
    ALEX BOHM; Fiscal Year: 2009
    ..is significantly different from that of better studied family members such as murine polyomavirus and simian virus 40 (SV40)...
  39. VIRAL REGULATION OF RIBOSOMAL RNA TRANSCRIPTION
    Lucio Comai; Fiscal Year: 1999
    DESCRIPTION (adapted from the applicant's abstract): Simian virus 40 (SV40) large T antigen is a multifunctional regulatory protein that plays a key role in the viral life cycle...
  40. VIRAL REGULATION OF RIBOSOMAL RNA TRANSCRIPTION
    Lucio Comai; Fiscal Year: 2000
    DESCRIPTION (adapted from the applicant's abstract): Simian virus 40 (SV40) large T antigen is a multifunctional regulatory protein that plays a key role in the viral life cycle...
  41. VIRAL REGULATION OF RIBOSOMAL RNA TRANSCRIPTION
    Lucio Comai; Fiscal Year: 2001
    DESCRIPTION (adapted from the applicant's abstract): Simian virus 40 (SV40) large T antigen is a multifunctional regulatory protein that plays a key role in the viral life cycle...
  42. MECHANISMS OF NUCLEAR PROTEIN ACCUMULATION
    PHILIP PAINE; Fiscal Year: 1990
    ..study the nucleocytoplasmic transport of (i) two widely-studied prototype N- proteins, nucleoplasmic and the simian virus 40 large T antigen (SV40 lg T), and (ii) macromolecular dextrans with covalently attached signal sequences of ..
  43. EARLY INTERACTIONS OF DNA VIRUSES AND HOST
    Gerd Maul; Fiscal Year: 2003
    ..We mapped the targeting DNA sequence for simian virus 40 (SV40) to the core origin of replication. Also DNA viruses begin to transcribe in association with ND10...
  44. EARLY INTERACTIONS OF DNA VIRUSES AND HOST
    Gerd Maul; Fiscal Year: 2001
    ..We mapped the targeting DNA sequence for simian virus 40 (SV40) to the core origin of replication. Also DNA viruses begin to transcribe in association with ND10...
  45. EARLY INTERACTIONS OF DNA VIRUSES AND HOST
    Gerd Maul; Fiscal Year: 2002
    ..We mapped the targeting DNA sequence for simian virus 40 (SV40) to the core origin of replication. Also DNA viruses begin to transcribe in association with ND10...
  46. EARLY INTERACTIONS OF DNA VIRUSES AND HOST
    Gerd Maul; Fiscal Year: 2004
    ..We mapped the targeting DNA sequence for simian virus 40 (SV40) to the core origin of replication. Also DNA viruses begin to transcribe in association with ND10...
  47. EARLY INTERACTIONS OF DNA VIRUSES AND HOST
    Gerd Maul; Fiscal Year: 2005
    ..We mapped the targeting DNA sequence for simian virus 40 (SV40) to the core origin of replication. Also DNA viruses begin to transcribe in association with ND10...
  48. CELL RECOGNITION AND RESPONSES TO EXTERNAL CARBOHYDRATES
    PAUL WEIGEL; Fiscal Year: 1980
    ..will be given to studies on growth control and cell motility since preliminary evidence suggests that simian virus 40 transformed Balb/c 3T3 cells will grow on a particular carbohydrate surface, whereas the non-transformed Balb/..
  49. SIMIAN VIRUS 40, DNA REPLICATION AND TRANSFORMATION
    GEORGE FAREED; Fiscal Year: 1980
    ....
  50. DEVELOPMENT OF AN SPF BABOON COLONY
    Gary White; Fiscal Year: 2006
    ..type D (SRV/D), simian immunodeficiency virus (SIV), and simian T cell lymphotropic virus (STLV)] and simian virus 40 (SV40)...
  51. DEVELOPMENT OF AN SPF BABOON COLONY
    Gary White; Fiscal Year: 2005
    ..type D (SRV/D), simian immunodeficiency virus (SIV), and simian T cell lymphotropic virus (STLV)] and simian virus 40 (SV40)...
  52. Selection of chemical inhibitors of oncoproteins
    Maurizio Bocchetta; Fiscal Year: 2001
    ..A growing body of evidence relates Simian Virus 40 (SV40) with tumors of the mesothelium, brain, and bone...
  53. DEVELOPMENT OF AN SPF BABOON COLONY
    Gary White; Fiscal Year: 2004
    ..type D (SRV/D), simian immunodeficiency virus (SIV), and simian T cell lymphotropic virus (STLV)] and simian virus 40 (SV40)...
  54. Selection of chemical inhibitors of oncoproteins
    Maurizio Bocchetta; Fiscal Year: 2002
    ..A growing body of evidence relates Simian Virus 40 (SV40) with tumors of the mesothelium, brain, and bone...
  55. DEVELOPMENT OF AN SPF BABOON COLONY
    Gary White; Fiscal Year: 2002
    ..type D (SRV/D), simian immunodeficiency virus (SIV), and simian T cell lymphotropic virus (STLV)] and simian virus 40 (SV40)...
  56. GROWTH CONTROL AND VIRAL GENE EXPRESSION
    ELIZABETH GURNEY; Fiscal Year: 1980
    ..proposed research is to clarify the role of the viral genome in transformation by the small DNA tumor virus, simian virus 40 (SV40)...
  57. HISTONE HYPERACETYLATION IN REPLICATING SV40 CHROMOSOMES
    Barry Milavetz; Fiscal Year: 2009
    Using the Simian Virus 40 (SV40) chromosome as a model for eukaryotic chromatin, the proposed research will address the role of histone hyperacetylation at an active replication fork and during post-replication chromatin maturation ..
  58. IN VIVO COCARCINOGENESIS OF CHEMICALS AND VIRUSES
    MARY HOWETT; Fiscal Year: 1980
    ..It is in light of this in vitro evidence, as well as work by others, that we have been encouraged to show in vivo cocarcinogenesis of chemical carcinogens with DNA tumor viruses. ..
  59. MOLECULAR BIOLOGY OF CAMPTOTHECIN INDUCED DNA DAMAGE
    ROBERT SNAPKA; Fiscal Year: 2000
    ..to our understanding of the cytotoxic mechanisms of camptothecins have been made with studies of simian virus 40 (SV40), a small double strand DNA virus which makes such extensive use of host cell chromosomal proteins and ..
  60. X-RAY DIFFRACTION STUDIES OF POLYOMA AND SV-40 VIRUS
    Eaton Lattman; Fiscal Year: 1980
    ..is distributed over the whole array. For specimens as thick as viruses multiple scattering limits this technique to medium resolution. True two-dimensional crystals of viruses have been observed...
  61. MOLECULAR BIOLOGY OF CAMPTOTHECIN INDUCED DNA DAMAGE
    ROBERT SNAPKA; Fiscal Year: 2002
    ..to our understanding of the cytotoxic mechanisms of camptothecins have been made with studies of simian virus 40 (SV40), a small double strand DNA virus which makes such extensive use of host cell chromosomal proteins and ..
  62. IMMORTALIZED HUMAN SKIN ENDOTHELIAL CELLS
    THOMAS LAWLEY; Fiscal Year: 1993
    ..endothelial cells by transforming pure cultures of human dermal microvascular endothelial cells (HDMEC) using simian virus 40 large T antigen...
  63. MOLECULAR BIOLOGY OF CAMPTOTHECIN INDUCED DNA DAMAGE
    ROBERT SNAPKA; Fiscal Year: 2001
    ..to our understanding of the cytotoxic mechanisms of camptothecins have been made with studies of simian virus 40 (SV40), a small double strand DNA virus which makes such extensive use of host cell chromosomal proteins and ..
  64. STRUCTURAL STUDIES OF NUCLEOPROTEIN COMPLEXES
    Edward Egelman; Fiscal Year: 2003
    ..coli DnaB, Simian Virus 40 large T, archaeal MCM and bacteriophage T7 gp4, to study the interaction with DNA, conformational changes ..
  65. STRUCTURAL STUDIES OF NUCLEOPROTEIN COMPLEXES
    Edward Egelman; Fiscal Year: 2002
    ..coli DnaB, Simian Virus 40 large T, archaeal MCM and bacteriophage T7 gp4, to study the interaction with DNA, conformational changes ..
  66. STRUCTURAL STUDIES OF NUCLEOPROTEIN COMPLEXES
    Edward Egelman; Fiscal Year: 2004
    ..coli DnaB, Simian Virus 40 large T, archaeal MCM and bacteriophage T7 gp4, to study the interaction with DNA, conformational changes ..