Genomes and Genes
simian virus 40
Summary: A species of POLYOMAVIRUS originally isolated from Rhesus monkey kidney tissue. It produces malignancy in human and newborn hamster kidney cell cultures.
Publications234 found, 100 shown here
- Role of SV40 ST antigen in the persistent infection of mesothelial cellsKelly M Fahrbach
Department of Microbiology Immunology and The Robert H Lurie Comprehensive Cancer Center, Northwestern University, 303 E Chicago Avenue, Chicago, IL 60611, USA
Virology 370:255-63. 2008....
- Simian Virus 40 depends on ER protein folding and quality control factors for entry into host cellsMario Schelhaas
Institute of Biochemistry, Schafmattstrasse 18, ETH Hoenggerberg, ETH Zurich, CH 8093, Zurich, Switzerland
Cell 131:516-29. 2007Cell entry of Simian Virus 40 (SV40) involves caveolar/lipid raft-mediated endocytosis, vesicular transport to the endoplasmic reticulum (ER), translocation into the cytosol, and import into the nucleus...
- Role of endosomes in simian virus 40 entry and infectionSabrina Engel
ETH Zurich, Institute of Biochemistry, Schafmattstrasse 18, 8093 Zurich, Switzerland
J Virol 85:4198-211. 2011After binding to its cell surface receptor ganglioside GM1, simian virus 40 (SV40) is endocytosed by lipid raft-mediated endocytosis and slowly transported to the endoplasmic reticulum, where partial uncoating occurs...
- Enumeration of the simian virus 40 early region elements necessary for human cell transformationWilliam C Hahn
Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
Mol Cell Biol 22:2111-23. 2002..We recently reported that coexpression of the simian virus 40 (SV40) early region (ER), the gene encoding the telomerase catalytic subunit (hTERT), and an oncogenic allele ..
- PML-nuclear bodies accumulate DNA in response to polyomavirus BK and simian virus 40 replicationAsne Jul-Larsen
Section of Anatomy and Cell Biology, Department of Biomedicine, University of Bergen, 5009, Norway
Exp Cell Res 298:58-73. 2004..labeling to demonstrate that PML-NBs accumulate newly synthesized DNA in cells infected by the polyomaviruses simian virus 40 (SV40) or polyomavirus BK (BKV)...
- Association of simian virus 40 vp1 with 70-kilodalton heat shock proteins and viral tumor antigensPeggy P Li
Molecular Biology Institute, 456 Boyer Hall, University of California at Los Angeles, 611 East Charles E Young Dr, Box 951570, Los Angeles, CA 90095 1570, USA
J Virol 83:37-46. 2009..The major capsid protein Vp1 of simian virus 40 forms a series of disulfide-linked intermediates during folding and capsid formation...
- Clathrin- and caveolin-1-independent endocytosis: entry of simian virus 40 into cells devoid of caveolaeEva-Maria Damm
Institute of Biochemistry, , , Switzerland
J Cell Biol 168:477-88. 2005b>Simian Virus 40 (SV40) has been shown to enter host cells by caveolar endocytosis followed by transport via caveosomes to the endoplasmic reticulum (ER)...
- Simian virus 40 small T antigen activates AMPK and triggers autophagy to protect cancer cells from nutrient deprivationSravanth Hindupur Kumar
Department of Molecular Reproduction, Development, and Genetics, Indian Institute of Science, Bangalore 560012, India
J Virol 83:8565-74. 2009..Using an in vitro transformation model where the presence of the simian virus 40 (SV40) small T (ST) antigen has been shown to be critical for tumorigenic transformation, we investigated ..
- Adenovirus E1A, simian virus 40 tumor antigen, and human papillomavirus E7 protein share the capacity to disrupt the interaction between transcription factor E2F and the retinoblastoma gene productS Chellappan
Howard Hughes Medical Institute, Department of Microbiology and Immunology, Duke University Medical Center, Durham, NC 27710
Proc Natl Acad Sci U S A 89:4549-53. 1992The adenovirus E1A gene product, the simian virus 40 large tumor antigen, and the human papillomavirus E7 protein share a short amino acid sequence that constitutes a domain required for the transforming activity of these proteins...
- Multiple DNA damage signaling and repair pathways deregulated by simian virus 40 large T antigenSergei Boichuk
University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15213, USA
J Virol 84:8007-20. 2010We demonstrated previously that expression of simian virus 40 (SV40) large T antigen (LT), without a viral origin, is sufficient to induce the hallmarks of a cellular DNA damage response (DDR), such as focal accumulation of gamma-H2AX ..
- Caveolar endocytosis of simian virus 40 is followed by brefeldin A-sensitive transport to the endoplasmic reticulum, where the virus disassemblesLeonard C Norkin
Department of Microbiology, University of Massachusetts, Amherst, Massachusetts 01003 5720, USA
J Virol 76:5156-66. 2002b>Simian virus 40 (SV40) enters cells by atypical endocytosis mediated by caveolae that transports the virus to the endoplasmic reticulum (ER) instead of to the endosomal-lysosomal compartment, which is the usual destination for viruses ..
- SV40 and human tumours: myth, association or causality?Adi F Gazdar
Hamon Center for Therapeutic Oncology Research and Department of Pathology, University of Texas Southwestern Medical Centre, Dallas, Texas 75390, USA
Nat Rev Cancer 2:957-64. 2002An increasing number of scientific reports have described evidence for a polyomavirus, simian virus 40, in a highly select group of human tumours...
- Exploitation of major histocompatibility complex class I molecules and caveolae by simian virus 40R G Parton
Department of Physiology and Pharmacology, University of Queensland, Brisbane, Australia
Immunol Rev 168:23-31. 1999b>Simian virus 40 (SV40), a non-enveloped DNA virus, is transported from the cell surface to the nucleus where virus replication occurs...
- Caveolin-stabilized membrane domains as multifunctional transport and sorting devices in endocytic membrane trafficLucas Pelkmans
Max Planck Institute for Molecular Cell Biology and Genetics, 01307 Dresden, Germany
Cell 118:767-80. 2004..Following transport of the caveolar protein Caveolin-1 and two cargo complexes, Simian Virus 40 and Cholera toxin, in live cells, we uncovered a Rab5-dependent pathway in which caveolar vesicles are ..
- A large and intact viral particle penetrates the endoplasmic reticulum membrane to reach the cytosolTakamasa Inoue
Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America
PLoS Pathog 7:e1002037. 2011..They also suggest that the ER membrane supports passage of a large particle, potentially through either a sizeable protein-conducting channel or the lipid bilayer...
- Activation of the tumor-specific death effector apoptin and its kinase by an N-terminal determinant of simian virus 40 large T antigenYing-Hui Zhang
Leadd B.V, Leiden, The Netherlands
J Virol 78:9965-76. 2004..cells apoptin can also be activated by the transient transforming signals conferred by ectopically expressed simian virus 40 (SV40) large T antigen (LT), which rapidly induces apoptin's phosphorylation, nuclear accumulation, and the ..
- Cell-type specific regulation of gene expression by simian virus 40 T antigensPaul G Cantalupo
Department of Biological Sciences, 559 Crawford Hall, University of Pittsburgh Pittsburgh, Pennsylvania 15260, USA
Virology 386:183-91. 2009....
- Cancer risk associated with receipt of vaccines contaminated with simian virus 40: epidemiologic researchEric A Engels
Division of Cancer Epidemiology and Genetics, National Cancer Institute, DHHS, 6120 Executive Blvd, EPS 8010 Rockville, MD 20892, USA
Expert Rev Vaccines 4:197-206. 2005....
- Absence of Epstein-Barr virus, human papillomavirus, and simian virus 40 in patients of central european origin with lymphoepithelioma-like carcinoma of the skinDmitry V Kazakov
Sikl s Department of Pathology, Charles University, Medical Faculty Hospital, Pilsen, Czech Republic
Am J Dermatopathol 29:365-9. 2007..Because all 10 cases studied proved negative for EBV, HPV, and SV40, these viruses seem to play no causal role in LELC of the skin in patients from Central Europe...
- Local actin polymerization and dynamin recruitment in SV40-induced internalization of caveolaeLucas Pelkmans
Swiss Federal Institute of Technology Zurich (ETHZ, HPM1 Building, , CH-8093 Zurich, Switzerland
Science 296:535-9. 2002b>Simian virus 40 (SV40) utilizes endocytosis through caveolae for infectious entry into host cells. We found that after binding to caveolae, virus particles induced transient breakdown of actin stress fibers...
- Histone hyperacetylation in the coding region of chromatin undergoing transcription in SV40 minichromosomes is a dynamic process regulated directly by the presence of RNA polymerase IILata Balakrishnan
Department of Biochemistry and Molecular Biology, University of North Dakota, Grand Forks, ND 58203, USA
J Mol Biol 365:18-30. 2007....
- Ataxia-telangiectasia-mutated (ATM) is a T-antigen kinase that controls SV40 viral replication in vivoYuling Shi
Department of Pharmacology, University of Wisconsin Medical School, Madison, Wisconsin 53706, USA
J Biol Chem 280:40195-200. 2005..Our findings uncover a direct link between ATM and SV40 LTag that may have implications for understanding the replication cycle of oncogenic polyoma viruses...
- Association with capsid proteins promotes nuclear targeting of simian virus 40 DNAA Nakanishi
Department of Molecular, Cell, and Developmental Biology, University of California, Los Angeles 90095, USA
Proc Natl Acad Sci U S A 93:96-100. 1996..The role of capsid proteins in nuclear targeting of simian virus 40 (SV40) DNA, which is assessed by the nuclear accumulation of large tumor (T) antigen, the initial sign of the ..
- Sequence requirements for plasmid nuclear importD A Dean
College of Medicine, University of South Alabama, Mobile, Alabama 36688, USA
Exp Cell Res 253:713-22. 1999..Thus, the inclusion this SV40 sequence in nonviral vectors may greatly increase their ability to be transported into the nucleus, especially in nondividing cells...
- A very late viral protein triggers the lytic release of SV40Robert Daniels
Department of Biochemistry and Molecular Biology, University of Massachusetts, Amherst, Massachusetts, United States of America
PLoS Pathog 3:e98. 2007How nonenveloped viruses such as simian virus 40 (SV40) trigger the lytic release of their progeny is poorly understood...
- Gangliosides are receptors for murine polyoma virus and SV40Billy Tsai
Howard Hughes Medical Institute and Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
EMBO J 22:4346-55. 2003Polyoma virus (Py) and simian virus 40 (SV40) travel from the plasma membrane to the endoplasmic reticulum (ER) from where they enter the cytosol and then the nucleus to initiate infection...
- Mutagenesis of a functional chimeric gene in yeast identifies mutations in the simian virus 40 large T antigen J domainSheara W Fewell
Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA
Proc Natl Acad Sci U S A 99:2002-7. 2002b>Simian virus 40 large T antigen contains an amino terminal J domain that catalyzes T antigen-mediated viral DNA replication and cellular transformation...
- Disassembly of simian virus 40 during passage through the endoplasmic reticulum and in the cytoplasmDmitry Kuksin
Department of Microbiology, University of Massachusetts, Amherst, Massachusetts, USA
J Virol 86:1555-62. 2012The nonenveloped polyomavirus simian virus 40 (SV40) is taken up into cells by a caveola-mediated endocytic process that delivers the virus to the endoplasmic reticulum (ER)...
- 19S late mRNAs of simian virus 40 have an internal ribosome entry site upstream of the virion structural protein 3 coding sequenceYongjun Yu
Department of Cancer Biology, Abramson Family Cancer Research Institute, 314 Biomedical Research Building, 421 Curie Blvd, University of Pennsylvania, Philadelphia, PA 19104-6142, USA
J Virol 80:6553-8. 2006The late mRNAs of simian virus 40 (SV40) are polycistronic. The 19S mRNAs encode primarily the virion structural proteins VP2 and VP3...
- Pairs of Vp1 cysteine residues essential for simian virus 40 infectionPeggy P Li
Molecular Biology Institute, 456 Boyer Hall, University of California at Los Angeles, 611 East Charles E Young Dr, Box 951570, Los Angeles, CA 90095 1570, USA
J Virol 79:3859-64. 2005Transient disulfide bonding occurs during the intracellular folding and pentamerization of simian virus 40 (SV40) major capsid protein Vp1 (P. P. Li, A. Nakanishi, S. W. Clark, and H. Kasamatsu, Proc. Natl. Acad. Sci...
- Mammalian DNA topoisomerase I activity and poisoning by camptothecin are inhibited by simian virus 40 large T antigenY Pommier
Laboratory of Molecular Pharmacology, National Cancer Institute, Bethesda, Maryland 20892 4255, USA
Biochemistry 37:3818-23. 1998..These results demonstrate a functional interaction between T-Ag and top1: they also suggest the importance of top1-protein interactions for the regulation of DNA replication and modulation of camptothecin activity...
- CD4+ T lymphocytes play a critical role in antibody production and tumor immunity against simian virus 40 large tumor antigenRonald C Kennedy
Department of Microbiology and Immunology, Texas Tech University Health Science Center, Lubbock, Texas 79430, USA
Cancer Res 63:1040-5. 2003..Our results suggest that CD4+ T cells, along with antibody responses, play a role in the induction of tumor immunity to a viral-encoded tumor antigen...
- Bucillamine induces the synthesis of vascular endothelial growth factor dose-dependently in systemic sclerosis fibroblasts via nuclear factor-kappaB and simian virus 40 promoter factor 1 pathwaysJörg H W Distler
Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland
Mol Pharmacol 65:389-99. 2004..The study provides evidence for a role of NF-kappaB in the transcriptional regulation of the VEGF gene. SA 96 might have positive aspects on the impaired angiogenesis in patients with SSc...
- Lipid rafts and caveolae as portals for endocytosis: new insights and common mechanismsRobert G Parton
Institute for Molecular Bioscience, Centre for Microscopy and Microanalysis, and School of Biomedical Sciences, University of Queensland, Queensland, 4072, Australia
Traffic 4:724-38. 2003..This review examines the current evidence for the involvement of rafts and caveolae in endocytosis and the molecular players involved in their regulation...
- Ataxia telangiectasia-mutated damage-signaling kinase- and proteasome-dependent destruction of Mre11-Rad50-Nbs1 subunits in Simian virus 40-infected primate cellsXiaorong Zhao
Department of Biological Sciences, Vanderbilt University, Nashville, Tennessee 37235 1634, USA
J Virol 82:5316-28. 2008Although the mechanism of simian virus 40 (SV40) DNA replication has been extensively investigated with cell extracts, viral DNA replication in productively infected cells utilizes additional viral and host functions whose interplay ..
- Development of quantitative and high-throughput assays of polyomavirus and papillomavirus DNA replicationAmelie Fradet-Turcotte
Laboratory of Molecular Virology, Institut de recherches cliniques de Montreal IRCM, Montreal, Quebec, Canada
Virology 399:65-76. 2010..These quantitative and high-throughput assays should greatly facilitate the study of SV40 and HPV31 DNA replication and the identification of small-molecule inhibitors of this process...
- Induction of interferon-stimulated genes by Simian virus 40 T antigensAbhilasha V Rathi
Department of Biological Sciences, University of Pittsburgh, 559 Crawford Hall, Pittsburgh, PA 15260, USA
Virology 406:202-11. 2010b>Simian virus 40 (SV40) large T antigen (TAg) is a multifunctional oncoprotein essential for productive viral infection and for cellular transformation...
- A distinct first replication cycle of DNA introduced in mammalian cellsGurangad S Chandok
Department of Biochemistry and Molecular Biology, Penn State University, University Park, PA 16801, USA
Nucleic Acids Res 39:2103-15. 2011..This work demonstrates, for the first time, differences in the replication progression during the first and subsequent replication cycles in mammalian cells...
- Immortalization of swine umbilical vein endothelial cells (SUVECs) with the simian virus 40 large-T antigenMarcin Chruściel
Department of Hormonal Action Mechanisms, Institute of Animal Reproduction and Food Research, Polish Academy of Science, Olsztyn, Poland
Mol Reprod Dev 78:597-610. 2011..We have generated an immortalized endothelial cell line, G-1410, using Simian virus 40 T-antigen (SV40 T-ag) primarily to overcome the short life span before the onset of senescence and high ..
- Productive simian virus 40 infection of neurons in immunosuppressed Rhesus monkeysXin Dang
Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
J Neuropathol Exp Neurol 67:784-92. 2008..Reactivation of simian virus 40 (SV40) in immunosuppressed rhesus monkeys, however, rarely causes a PML-like illness...
- Absence of SV40 and other polyomavirus (JCV, BKV) DNA in primary cutaneous B cell lymphomasSylke Gellrich
J Invest Dermatol 124:278-9. 2005
- Some oral poliovirus vaccines were contaminated with infectious SV40 after 1961Rochelle Cutrone
Thoracic Oncology Program, Cardinal Bernardin Cancer Center, Loyola University, Chicago, Illinois, USA
Cancer Res 65:10273-9. 2005..Moreover, our results indicate possible geographic differences in SV40 exposure and offer a possible explanation for the different percentage of SV40-positive tumors detected in some laboratories...
- The binding of topoisomerase I to T antigen enhances the synthesis of RNA-DNA primers during simian virus 40 DNA replicationSujata Khopde
Department of Biological Sciences, University of Delaware, Newark, Delaware 19716 2590, USA
Biochemistry 47:9653-60. 2008Topoisomerase I (topo I) is required for the proper initiation of simian virus 40 (SV40) DNA replication...
- Simian virus 40 large T antigen disrupts genome integrity and activates a DNA damage response via Bub1 bindingJennifer Hein
Hillman Cancer Center, Research Pavilion Suite 1 8, 5117 Centre Avenue, Pittsburgh, PA 15213, USA
J Virol 83:117-27. 2009b>Simian virus 40 (SV40) large T antigen (LT) is a multifunctional protein that is important for viral replication and oncogenic transformation...
- Efficient delivery of RNA interference effectors via in vitro-packaged SV40 pseudovirionsChava Kimchi-Sarfaty
Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-4256, USA
Hum Gene Ther 16:1110-5. 2005Previously we have shown that in vitro-packaged simian virus 40 (SV40) pseudovirions (IVPs) are an efficient delivery system for supercoiled DNA plasmids of up to 17.7 kb, with or without SV40 sequences...
- Wild-type p53 enhances efficiency of simian virus 40 large-T-antigen-induced cellular transformationAndrea Hermannstädter
Heinrich Pette Institute for Experimental Virology and Immunology Martinistr 52, D 20251 Hamburg, Germany
J Virol 83:10106-18. 2009..infection of BALB/c mouse embryo fibroblasts differing in p53 gene status (p53(+/+) versus p53(-/)(-)) with simian virus 40 (SV40) revealed a quantitatively and qualitatively decreased transformation efficiency in p53(-/-) cells ..
- In vitro assessment of the cytotoxicity of nisin, pediocin, and selected colicins on simian virus 40-transfected human colon and Vero monkey kidney cells with trypan blue staining viability assaysS E Murinda
Department of Food Science, Pennsylvania State University, University Park, Pennsylvania 16802, USA
J Food Prot 66:847-53. 2003..bacteriocins (colicins [Col] E1, E3, E6, E7, and K) were evaluated for cytotoxicity against cultured simian virus 40-transfected human colon (SV40-HC) and Vero monkey kidney (Vero) cells...
- Overexpression of diacylglycerol acyltransferase-1 reduces phospholipid synthesis, proliferation, and invasiveness in simian virus 40-transformed human lung fibroblastsCarolina Bagnato
Instituto de Investigaciones Bioquímicas de La Plata INIBIOLP, CONICET UNLP, Facultad de Ciencias Medicas, Universidad Nacional de La Plata, calles 60 y 120, 1900 La Plata, Argentina
J Biol Chem 278:52203-11. 2003..These results strongly support the view that DGAT participates in the regulation of membrane lipid synthesis and lipid signaling, thereby playing an important role in modulating cell growth properties...
- Long-term controlled immortalization of a primate hepatic progenitor cell line after Simian virus 40 T-Antigen gene transferJean-Paul Delgado
INSERM EMI 00-20; University Paris XI, , , , France
Oncogene 24:541-51. 2005..we describe the long-term behaviour of a clone of simian foetal hepatic progenitor cells immortalized by Simian virus 40 (SV40) large T-antigen (T-Ag) flanked by loxP sites...
- Establishment and partial characterization of an ovine synovial membrane cell line obtained by transformation with Simian Virus 40 T antigenU M Costa
, , Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil
J Virol Methods 128:72-8. 2005..Finally, the transformed ovine synovial membrane cells were shown to be permissive to small ruminant lentiviruses, and these are suggested as a cell line for in vitro isolation and propagation of these viruses...
- Intestinal dysplasia induced by simian virus 40 T antigen is independent of p53Jennifer A Markovics
Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA
J Virol 79:7492-502. 2005Transgenic mice expressing simian virus 40 large T antigen in enterocytes develop intestinal hyperplasia that progresses to dysplasia with age...
- Cul7/p185/p193 binding to simian virus 40 large T antigen has a role in cellular transformationSyed Hamid Ali
Department of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
J Virol 78:2749-57. 2004b>Simian virus 40 large T antigen (TAg) is a viral oncoprotein that can promote cellular transformation...
- The role of insulin receptor substrate-1 in the oncogenicity of simian virus 40 T antigenAn Wu
Thomas Jefferson University, Department of Cancer Biology, Kimmel Cancer Center, Philadelphia, Pennsylvania 19107, USA
Cell Cycle 7:1999-2002. 2008The Simian Virus 40 large T antigen (Tag) and the insulin receptor substrate-1 (IRS-1) interact with each other...
- Targeting CCR5 with siRNAs: using recombinant SV40-derived vectors to protect macrophages and microglia from R5-tropic HIVPierre Cordelier
Department of Pathology and Cell Biology, Jefferson Medical College, Philadelphia, PA 19107, USA
Oligonucleotides 13:281-94. 2003..Therefore, strategies to target CCR5 using rSV40-delivered, VA promoter-driven siRNAs may be useful therapeutic options for treating HIV infection...
- Mutational analysis of simian virus 40 T antigen: isolation and characterization of mutants with deletions in the T-antigen geneJ M Pipas
Mol Cell Biol 3:203-13. 1983A series of mutants of simian virus 40 has been constructed with deletions in the coding sequence for large T antigen. Nucleotide sequence analysis indicates that 4 mutants have in-phase and 11 have out-of-phase deletions...
- Presence of simian virus 40 DNA sequences in diffuse large B-cell lymphomas in Tunisia correlates with aberrant promoter hypermethylation of multiple tumor suppressor genesKhaled Amara
Laboratory of Pathology, CHU Farhat Hached, Sousse, Tunisia
Int J Cancer 121:2693-702. 2007..The significant association of promoter hypermethylation of multiple TSGs with the presence of SV40 DNA in DLBCLs supports a functional effect of the virus in those lymphomas...
- Identification of the SV40 agnogene product: a DNA binding proteinG Jay
Nature 291:346-9. 1981
- The simian virus 40 minimal origin and the 72-base-pair repeat are required simultaneously for efficient induction of late gene expression with large tumor antigenS W Hartzell
Proc Natl Acad Sci U S A 81:6335-9. 1984We have studied the temporal regulation of simian virus 40 (SV40) late gene expression by construction and transient expression analysis of plasmids containing the transposon Tn9 chloramphenicol acetyltransferase gene placed downstream ..
- The T/t common exon of simian virus 40, JC, and BK polyomavirus T antigens can functionally replace the J-domain of the Escherichia coli DnaJ molecular chaperoneW L Kelley
Departement de Biochimie Medicale, Centre Medical Universitaire, Universite de Geneve, Geneva, Switzerland
Proc Natl Acad Sci U S A 94:3679-84. 1997..yet significant, amino acid sequence homology to the J-domain, the DNA encoding the T/t common exon of the simian virus 40 (SV40), JC, or BK polyoma virus T antigen oncoproteins was used to construct J-domain replacement chimeras of ..
- The relationship between simian virus 40 and mesotheliomaZeyana Rivera
Cancer Research Center of Hawaii and Department of Pathology, University of Hawaii, Honolulu, Hawaii, USA
Curr Opin Pulm Med 14:316-21. 2008b>Simian virus 40 is present in some human malignant mesotheliomas. The evidence in favor and against a pathogenic role of simian virus 40 in malignant mesothelioma is discussed in this review.
- Complete enzymatic synthesis of DNA containing the SV40 origin of replicationY Ishimi
Memorial Sloan Kettering Cancer Center, Graduate Program in Molecular Biology, New York, New York 10021
J Biol Chem 263:19723-33. 1988The replication of simian virus 40 origin-containing DNA has been reconstituted in vitro with SV40 large T antigen and purified proteins isolated from HeLa cells...
- High levels of luteinizing hormone analog stimulate gonadal and adrenal tumorigenesis in mice transgenic for the mouse inhibin-alpha-subunit promoter/Simian virus 40 T-antigen fusion geneMaarit Mikola
Department of Physiology, University of Turku, FIN-20520 Turku, Finland
Oncogene 22:3269-78. 2003Transgenic (TG) mice expressing the Simian virus 40 T-antigen under the control of the murine inhibin-alpha promoter (Inhalpha/Tag) develop granulosa and Leydig cell tumors at the age of 5-6 months, with 100% penetrance...
- SR alpha promoter: an efficient and versatile mammalian cDNA expression system composed of the simian virus 40 early promoter and the R-U5 segment of human T-cell leukemia virus type 1 long terminal repeatY Takebe
Department of Molecular Biology, DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, California 94304
Mol Cell Biol 8:466-72. 1988We developed a novel promoter system, designated SR alpha, which is composed of the simian virus 40 (SV40) early promoter and the R segment and part of the U5 sequence (R-U5') of the long terminal repeat of human T-cell leukemia virus ..
- Insights into hRPA32 C-terminal domain--mediated assembly of the simian virus 40 replisomeAlphonse I Arunkumar
Department of Biochemistry, Vanderbilt University, Nashville Tennessee 37232 8725 USA
Nat Struct Mol Biol 12:332-9. 2005b>Simian virus 40 (SV40) provides a model system for the study of eukaryotic DNA replication, in which the viral protein, large T antigen (Tag), marshals human proteins to replicate the viral minichromosome...
- Inhibitors of COP-mediated transport and cholera toxin action inhibit simian virus 40 infectionAyanthi A Richards
Institute for Molecular Bioscience, Center for Microscopy and Microanalysis, Queensland 4072, Australia
Mol Biol Cell 13:1750-64. 2002b>Simian virus 40 (SV40) is a nonenveloped virus that has been shown to pass from surface caveolae to the endoplasmic reticulum in an apparently novel infectious entry pathway...
- SV40 17KT antigen complements dnaj mutations in large T antigen to restore transformation of primary human fibroblastsAnita Boyapati
Department of Microbiology-Immunology and The Robert H. Lurie Comprehensive Cancer Center, Northwestern University, 303 E. Chicago Avenue, Chicago, IL 60611, USA
Virology 315:148-58. 2003..Similar to large T, this protein reduces levels of the retinoblastoma-related protein, p130, and stimulates cell-cycle progression of quiescent fibroblasts, two activities of large T that are disrupted by dnaJ mutations...
- SV40 Tag DNA sequences, present in a small proportion of human hepatocellular carcinomas, are associated with reduced survivalN A C S Wong
Department of Pathology, University of Edinburgh Medical School, Edinburgh EH8 9AG, UK
J Clin Pathol 56:904-9. 2003To study the association between simian virus 40 (SV40) and human hepatocarcinogenesis.
- Presence of simian virus 40 DNA sequences in human lymphoid and hematopoietic malignancies and their relationship to aberrant promoter methylation of multiple genesNarayan Shivapurkar
Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas 75390-8593, USA
Cancer Res 64:3757-60. 2004..Our results demonstrate that the presence of SV40 in hematological malignancies is associated with promoter methylation of TSGs and that in all probability, the virus plays a role in tumor pathogenesis...
- Simian virus 40 infection in lymphoproliferative disordersDaniela Capello
Baylor Coll Med, Houston, TX
Lancet 361:88-9. 2003
- T antigen origin-binding domain of simian virus 40: determinants of specific DNA bindingElizabeth M Bradshaw
Department of Biochemistry, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
Biochemistry 43:6928-36. 2004..1997) Biopolymers 44, 153-180), which may be the solution to the well-known paradox between the relatively modest DNA-binding specificity exhibited by initiator proteins and the high specificity of initiation...
- SV40 detection in human tumor specimensMichele Carbone
Cancer Res 65:10120-1. 2005
- A sequence motif in the simian virus 40 (SV40) early core promoter affects alternative splicing of transcribed mRNAElisenda Gendra
Rockefeller University, New York, New York 10021, USA
J Biol Chem 282:11648-57. 2007....
- Definition of the minimal simian virus 40 large T antigen- and adenovirus E1A-binding domain in the retinoblastoma gene productW G Kaelin
Dana Farber Cancer Institute, Boston, Massachusetts 02115
Mol Cell Biol 10:3761-9. 1990It has previously been demonstrated that the simian virus 40 large T antigen and adenovirus E1A proteins can form complexes with the retinoblastoma susceptibility gene product (RB)...
- Downregulation of protein disulfide isomerase inhibits infection by the mouse polyomavirusJoanna Gilbert
Department of Pathology, NRB-939I, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
J Virol 80:10868-70. 2006..b>Simian virus 40 infection was not inhibited in PDI-downregulated cells...
- Characterization of the 5'-terminal structure of simian virus 40 early mRNA'sJ A Thompson
J Virol 31:437-46. 1979RPC-5 reverse-phase chromatography has been used to isolate fragments of simian virus 40 DNA generated by appropriate digestions with restriction endonucleases...
- Structural basis of GM1 ganglioside recognition by simian virus 40Ursula Neu
Interfaculty Institute for Biochemistry, University of Tubingen, Hoppe Seyler Strasse 4, D 72076 Tubingen, Germany
Proc Natl Acad Sci U S A 105:5219-24. 2008b>Simian virus 40 (SV40) has been a paradigm for understanding attachment and entry of nonenveloped viruses, viral DNA replication, and virus assembly, as well as for endocytosis pathways associated with caveolin and cholesterol...
- In vitro splicing of simian virus 40 early pre mRNAJ C Noble
Nucleic Acids Res 14:1219-35. 1986The products of splicing of simian virus 40 early pre mRNA in HeLa cell nuclear extracts have been characterized...
- Functional cooperation of simian virus 40 promoter factor 1 and CCAAT/enhancer-binding protein beta and delta in lipopolysaccharide-induced gene activation of IL-10 in mouse macrophagesYi Wen Liu
Graduate Institute of Biopharmaceutics, College of Life Science, National Chiayi University, Chiayi, Taiwan
J Immunol 171:821-8. 2003..The increase of C/EBPbeta and delta proteins and the enhancement of transactivation activity of C/EBPbeta and delta by LPS treatment, at least in part, explain the activation of IL-10 gene expression...
- SV40 Pseudovirion gene delivery of a toxin to treat human adenocarcinomas in miceC Kimchi-Sarfaty
Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-4256, USA
Cancer Gene Ther 13:648-57. 2006..These results indicate that SV40 in vitro packaging is an effective system for cancer gene delivery using two different routes of injection and in combination with chemotherapy...
- Structural basis for the cooperative assembly of large T antigen on the origin of replicationMikel Valle
Centro Nacional de Biotecnologia, Darwin 3, Cantoblanco 28049 Madrid, Spain
J Mol Biol 357:1295-305. 2006Large T antigen (LTag) from simian virus 40 (SV40) is an ATP-driven DNA helicase that specifically recognizes the core of the viral origin of replication (ori), where it oligomerizes as a double hexamer...
- The role of the SV40 ST antigen in cell growth promotion and transformationK Rundell
Department of Microbiology Immunology, Northwestern University, and the Robert H Lurie Comprehensive Cancer Center, Chicago, IL 60611, USA
Semin Cancer Biol 11:5-13. 2001The simian virus 40 small-t (ST) antigen plays a key role in permissive and nonpermissive infections, increasing virus yields in lytic cycles of primate cells and enhancing the ability of large-T (LT) to transform rodent or even human ..
- Involvement of PP2A in viral and cellular transformationJason D Arroyo
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA
Oncogene 24:7746-55. 2005Although the small DNA tumor virus SV40 (simian virus 40) fails to replicate in human cells, understanding how SV40 transforms human and murine cells has and continues to provide important insights into cancer initiation and maintenance...
- Promoter of the adenovirus polypeptide IX gene: similarity to E1B and inactivation by substitution of the simian virus 40 TATA elementL E Babiss
University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway 08854 5635
J Virol 65:598-605. 1991..While the simian virus 40 (SV40) early promoter is capable of directing pIX mRNA synthesis from the SV40 cap sites, substitution of the ..
- Simian virus 40 T/t antigens and lamin A/C small interfering RNA rescue the phenotype of an Epstein-Barr virus protein kinase (BGLF4) mutantQiao Meng
Department of Oncology, McArdle Laboratory for Cancer Research, School of Medicine and Public Health, University of Wisconsin Madison, Madison, WI 53706, USA
J Virol 84:4524-33. 2010..Furthermore, the phenotype of the PKmut in 293 cells is substantially reversed by expression of the simian virus 40 (SV40) large (T) and small (t) T antigens. Efficient rescue requires the presence of both SV40 T/t proteins...
- NBS1 mediates ATR-dependent RPA hyperphosphorylation following replication-fork stall and collapseKaroline C Manthey
Department of Oral Biology, University of Nebraska Medical Center College of Dentistry and Nebraska Center for Cellular Signaling, Lincoln, NE 68583, USA
J Cell Sci 120:4221-9. 2007..Our findings suggest that RPA hyperphosphorylation requires NBS1 and is important for the cellular response to DNA damage...
- Cellular and molecular parameters of mesotheliomaMaria E Ramos-Nino
Department of Pathology, University of Vermont College of Medicine, Burlington, Vermont 05405, USA
J Cell Biochem 98:723-34. 2006..with no documented exposures to asbestos fibers, and emerging data suggest that genetic susceptibility and simian virus 40 (SV40) infections also facilitate the development of MMs...
- SV40 multiple tissue infection and asbestos exposure in a hyperendemic area for malignant mesotheliomaManola Comar
Department of Public Medicine Sciences, University of Trieste, Trieste, Italy
Cancer Res 67:8456-9. 2007..045). This survey shows that SV40 sustains infections in multiple tissues in malignant mesothelioma patients from a geographic area affected with asbestos-related mesothelioma...
- Simian virus 40 DNA replication is dependent on an interaction between topoisomerase I and the C-terminal end of T antigenSujata Khopde
Department of Biological Sciences, University of Delaware, Newark, DE 19716, USA
J Virol 82:1136-45. 2008Topoisomerase I (topo I) is needed for efficient initiation of simian virus 40 (SV40) DNA replication and for the formation of completed DNA molecules...
- Proteomics profiling of the cone photoreceptor cell line, 661WMuayyad R Al-Ubaidi
Department of Cell Biology, University of Oklahoma Health Sciences Center, 940 Stanton L. Young Blvd. (BMSB781, Oklahoma City, OK 73104, USA
Adv Exp Med Biol 613:301-11. 2008
- Establishment of permanent cell lines purified from human mesothelioma: morphological aspects, new marker expression and karyotypic analysisMarie Marthe Philippeaux
Department of Thoracic Surgery, Cantonal Hospital of Geneva University, 1, Rue Micheli du Crest, 1211, 4, Switzerland
Histochem Cell Biol 122:249-60. 2004..Karyotypic analyses showed more complex abnormalities in the epithelioid subtype than in the sarcomatoid form. These cell lines may be useful in the study of cellular, molecular and genetic aspects of the disease...
- Different susceptibility of human mesothelial cells to polyomavirus infection and malignant transformationMichele Carbone
Cardinal Bernardin Cancer Center, Department of Pathology, Loyola University Chicago, 2160 South First Avenue, Maywood, IL 60153, USA
Cancer Res 63:6125-9. 2003..SV40 did not lyse mesothelial cells and caused a high rate of transformation. These findings provide a rationale for the observation that SV40 is found in mesothelioma, rather than the ubiquitous human JCV and BKV...
- High throughput testing of the SV40 Large T antigen binding to cellular p53 identifies putative drugs for the treatment of SV40-related cancersMichele Carbone
Loyola University Medical Center, Cardinal Bernardin Cancer Center, Department of Pathology, Maywood, IL 60153, USA
Virology 315:409-14. 2003..We propose that our in vitro assay is a useful method to identify molecules that may be used as therapeutic agents for the treatment of SV40-related human cancers...
- Detection of polyomavirus SV40 in tonsils from immunocompetent childrenNiraj C Patel
Department of Pediatrics, Section of Infectious Diseases, Baylor College of Medicine, Houston, TX 77030, United States
J Clin Virol 43:66-72. 2008BK virus (BKV), JC virus (JCV) and simian virus 40 (SV40) are nonenveloped DNA viruses, members of the family Polyomaviridae...
- SV40-positive brain tumor in scientist with risk of laboratory exposure to the virusAmy S Arrington
Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA
Oncogene 23:2231-5. 2004b>Simian virus 40 (SV40) is a DNA tumor virus known to induce cancers in laboratory animals...
- Immortalization of hepatic progenitor cellsAnne Weber
IPSC, EMI 00 20, Hopital Antoine Beclere, 157, rue de la Porte de Trivaux, 92141 Clamart Cedex, France
Pathol Biol (Paris) 52:93-6. 2004..These studies suggest new approaches to expand hepatic progenitor cells, analyse their fate in animal models aiming at cell therapy of hepatic diseases...
- Hepatitis B virus enhances transduction of human hepatocytes by SV40-based vectorsUri Arad
Department of Hematology and Goldyne Savad Gene Therapy Institute, The Hebrew University-Hadassah Medical School and Hadassah University Hospital, Jerusalem, Israel
J Hepatol 40:520-6. 2004..CONCLUSIONS: HBV increases transduction by SV40-vectors. This is due to enhanced vector entry and/or transport into the nucleus. SV40-vectors appear to have a potential for gene therapy for the treatment of HBV infections...
- Evaluation of simian virus-40 as a biological prognostic factor in Egyptian patients with malignant pleural mesotheliomaAbdel Rahman N Zekri
Virology and Immunology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, Cairo, Egypt
Pathol Int 57:493-501. 2007..Combined positivity for SV40 and asbestos exposure is an independent prognostic factor in MPM, having a detrimental effect on OS...
- Simian virus 40 and lymphoproliferative disorderMatteo Giovanni Della Porta
University of Pavia Medical School, Division of Hematology, IRCCS Policlinico San Matteo, 27100 Pavia, Italy
Haematologica 90:1587. 2005
- Lymphoproliferative disorders in Costa Rica and simian virus 40Armando Meneses
Department of Pathology, Hospital San Juan de Dios, San Jose, Costa Rica
Haematologica 90:1635-42. 2005BACKGROUND AND OBJECTIVES. Simian virus 40 (SV40) is an oncogenic DNA virus implicated in some human malignancies, including lymphomas...
- Human polyoma virus in kidney transplants: SV40 T-antigen demonstration in the urineE von Willebrand
Transplantation Laboratory, University of Helsinki and Hospital for Children and Adolescents, Helsinki, Finland
Transplant Proc 37:945-6. 2005..Immunostaining of urine cytology with SV40-T-antibody seems to be useful in the diagnosis and follow-up of polyoma virus reactivation disease in transplant patients, especially in children with renal transplants...
- Evidence against a role for SV40 in human mesotheliomaJames J Manfredi
Department of Oncological Sciences, Mount Sinai School of Medicine, New York, New York, USA
Cancer Res 65:2602-9. 2005..Taken together, these findings strongly argue against a role of SV40 by any known transformation mechanism in the etiology of the majority of human malignant mesotheliomas...
- VIRAL REGULATION OF RIBOSOMAL RNA TRANSCRIPTIONLucio Comai; Fiscal Year: 2002DESCRIPTION (adapted from the applicant's abstract): Simian virus 40 (SV40) large T antigen is a multifunctional regulatory protein that plays a key role in the viral life cycle...
- MICROSCOPY & IMAGE ANALYSIS OF UNSTAINED MACROMOLECULESTimothy Baker; Fiscal Year: 1993..These include members of the Papovaviridae (polyoma virus, simian virus 40, and bovine, human, and cottontail rabbit papilloma viruses), the Reoviridae (rhesus rotavirus and serotype-1 ..
- INTRACELLULAR MECHANISMS OF GLUCOCORTICOID ACTIONDonald Defranco; Fiscal Year: 1999..shown to be required for the in vivo and in vitro nuclear import of various karyophilic proteins, such as the simian virus 40 large tumor antigen (SV40 TAg)...
- A chemical genetic approach to inhibiting T-ag assembly on the viral originPeter Bullock; Fiscal Year: 2007..will be searched for members that are able to disrupt the assembly of a prototype viral initiator termed Simian Virus 40 T-antigen...
- MECHANISMS OF POLYADENYLATION IN VIRAL SYSTEMSJAMES ALWINE; Fiscal Year: 1993..The simian virus 40 (SV40) late polyadenylation signal has these elements; however, we have found that it functions efficiently ..
- Hyperacetylation of Biologically Active SV40 ChromatinBarry Milavetz; Fiscal Year: 2006Using simian virus 40 (SV40) as a model for infections by DNA viruses, the proposed research will contribute to our understanding of the relationship between chromatin remodeling through histone modification and the activation of an ..
- REGULATION OF DNA TUMOR VIRUS GENE EXPRESSIONJAMES ALWINE; Fiscal Year: 2000b>Simian virus 40 large T antigen is a promiscuous activator of many viral and cellular promoters...
- HPV DNA REPLICATION: NOVEL HOST FACTORSThomas Melendy; Fiscal Year: 2003..Bruce Stillman studying simian virus 40 (SV40) DNA replication factors and mechanisms. Dr...
- AIDS-assoc Progressive Multifocal LeukoencephalopathyIgor Koralnik; Fiscal Year: 2004..Due to the narrow host range of JCV, there is no adequate animal model for its study. The Simian Virus 40 (SV40) has 69% homology with JCV, and has been associated with a PML like disease in immunosuppressed monkeys...
- EARLY INTERACTIONS OF DNA VIRUSES AND HOSTGerd Maul; Fiscal Year: 2005..We mapped the targeting DNA sequence for simian virus 40 (SV40) to the core origin of replication. Also DNA viruses begin to transcribe in association with ND10...
- DEVELOPMENT OF AN SPF BABOON COLONYGary White; Fiscal Year: 2006..type D (SRV/D), simian immunodeficiency virus (SIV), and simian T cell lymphotropic virus (STLV)] and simian virus 40 (SV40)...
- Selection of chemical inhibitors of oncoproteinsMaurizio Bocchetta; Fiscal Year: 2002..A growing body of evidence relates Simian Virus 40 (SV40) with tumors of the mesothelium, brain, and bone...
- MOLECULAR BIOLOGY OF CAMPTOTHECIN INDUCED DNA DAMAGEROBERT SNAPKA; Fiscal Year: 2002..to our understanding of the cytotoxic mechanisms of camptothecins have been made with studies of simian virus 40 (SV40), a small double strand DNA virus which makes such extensive use of host cell chromosomal proteins and ..
- STRUCTURAL STUDIES OF NUCLEOPROTEIN COMPLEXESEdward Egelman; Fiscal Year: 2004..coli DnaB, Simian Virus 40 large T, archaeal MCM and bacteriophage T7 gp4, to study the interaction with DNA, conformational changes ..