cytomegalovirus

Summary

Summary: A genus of the family HERPESVIRIDAE, subfamily BETAHERPESVIRINAE, infecting the salivary glands, liver, spleen, lungs, eyes, and other organs, in which they produce characteristically enlarged cells with intranuclear inclusions. Infection with Cytomegalovirus is also seen as an opportunistic infection in AIDS.

Top Publications

  1. ncbi Host immune system gene targeting by a viral miRNA
    Noam Stern-Ginossar
    Lautenberg Center for General and Tumor Immunology, Hebrew University Hadassah Medical School, Jerusalem, Israel
    Science 317:376-81. 2007
  2. ncbi Human cytomegalovirus activates inflammatory cytokine responses via CD14 and Toll-like receptor 2
    Teresa Compton
    McArdle Laboratory for Cancer Research, University of Wisconsin Madison Medical School, Madison, Wisconsin 53706, USA
    J Virol 77:4588-96. 2003
  3. ncbi Evasion of CD8+ T cells is critical for superinfection by cytomegalovirus
    Scott G Hansen
    Vaccine and Gene Therapy Institute, Oregon Health and Science University, 505 Northwest 185th Avenue, Beaverton, OR 97006, USA
    Science 328:102-6. 2010
  4. ncbi NKG2D ligand MICA is retained in the cis-Golgi apparatus by human cytomegalovirus protein UL142
    Omodele Ashiru
    Department of Pathology, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom
    J Virol 83:12345-54. 2009
  5. ncbi Review of cytomegalovirus seroprevalence and demographic characteristics associated with infection
    Michael J Cannon
    National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention CDC, Atlanta, GA 30329, USA
    Rev Med Virol 20:202-13. 2010
  6. ncbi Investigation of CMV disease in immunocompromised patients
    V C Emery
    Department of Virology, Royal Free and University College Medical School, Royal Free Campus, Rowland Hill Street, London NW3 2PF, UK
    J Clin Pathol 54:84-8. 2001
  7. ncbi Epidermal growth factor receptor is a cellular receptor for human cytomegalovirus
    Xin Wang
    Lineberger Comprehensive Cancer Center, Department of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7295, USA
    Nature 424:456-61. 2003
  8. ncbi Genetic content of wild-type human cytomegalovirus
    Aidan Dolan
    MRC Virology Unit, Institute of Virology, Church Street, Glasgow G11 5JR, UK
    J Gen Virol 85:1301-12. 2004
  9. ncbi Platelet-derived growth factor-alpha receptor activation is required for human cytomegalovirus infection
    Liliana Soroceanu
    Department of Neurosciences, California Pacific Medical Center Research Institute, Suite 220, 475 Brannan Street, San Francisco, California 94107, USA
    Nature 455:391-5. 2008
  10. ncbi Identification of proteins in human cytomegalovirus (HCMV) particles: the HCMV proteome
    Susan M Varnum
    Department of Molecular Microbiology and Immunology, Oregon Health Sciences University, Portland, OR 97201, USA
    J Virol 78:10960-6. 2004

Research Grants

  1. CYTOMEGALOVIRUS DNA REPLICATION AND INVERSION
    Edward Mocarski; Fiscal Year: 1991
  2. Ribozymes for studies and treatment of cytomegalovirus infections
    Fenyong Liu; Fiscal Year: 2009
  3. Ribozymes for studies and treatment of cytomegalovirus infections
    Fenyong Liu; Fiscal Year: 2010
  4. T CELLS IN LUNG INFLAMMATION
    Peter Kao; Fiscal Year: 2000
  5. CD8+ T Cell Immunity to Cytomegalovirus
    Stanley R Riddell; Fiscal Year: 2010
  6. Virologic and Immunologic Studies of Murine CMV Retinitis
    Sally Atherton; Fiscal Year: 2009
  7. Virologic and Immunologic Studies of Murine CMV Retinitis
    Sally S Atherton; Fiscal Year: 2010
  8. Defense Mechanisms Against CMV Brain Infection
    JAMES LOKENSGARD; Fiscal Year: 2007
  9. CYTOMEGALOVIRUS PATHOGENESIS IN IMMUNODEFICIENCY
    Edward Mocarski; Fiscal Year: 1993
  10. Human Cytomegalovirus-Induced Inhibition of Cytotrophoblast Invasion
    CINDY ANNE MORRIS; Fiscal Year: 2010

Detail Information

Publications301 found, 100 shown here

  1. ncbi Host immune system gene targeting by a viral miRNA
    Noam Stern-Ginossar
    Lautenberg Center for General and Tumor Immunology, Hebrew University Hadassah Medical School, Jerusalem, Israel
    Science 317:376-81. 2007
    ..We developed an algorithm for the prediction of miRNA targets and applied it to human cytomegalovirus miRNAs, resulting in the identification of the major histocompatibility complex class I-related chain B (MICB)..
  2. ncbi Human cytomegalovirus activates inflammatory cytokine responses via CD14 and Toll-like receptor 2
    Teresa Compton
    McArdle Laboratory for Cancer Research, University of Wisconsin Madison Medical School, Madison, Wisconsin 53706, USA
    J Virol 77:4588-96. 2003
    Human cytomegalovirus (CMV) is a ubiquitous opportunistic pathogen that causes significant morbidity and mortality in immunocompromised people...
  3. ncbi Evasion of CD8+ T cells is critical for superinfection by cytomegalovirus
    Scott G Hansen
    Vaccine and Gene Therapy Institute, Oregon Health and Science University, 505 Northwest 185th Avenue, Beaverton, OR 97006, USA
    Science 328:102-6. 2010
    b>Cytomegalovirus (CMV) can superinfect persistently infected hosts despite CMV-specific humoral and cellular immunity; however, how it does so remains undefined...
  4. ncbi NKG2D ligand MICA is retained in the cis-Golgi apparatus by human cytomegalovirus protein UL142
    Omodele Ashiru
    Department of Pathology, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom
    J Virol 83:12345-54. 2009
    Human cytomegalovirus (HCMV) evades T-cell recognition by down-regulating expression of major histocompatibility complex (MHC) class I and II molecules on the surfaces of infected cells...
  5. ncbi Review of cytomegalovirus seroprevalence and demographic characteristics associated with infection
    Michael J Cannon
    National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention CDC, Atlanta, GA 30329, USA
    Rev Med Virol 20:202-13. 2010
    b>Cytomegalovirus establishes a lifelong latent infection following primary infection that can periodically reactivate with shedding of infectious virus...
  6. ncbi Investigation of CMV disease in immunocompromised patients
    V C Emery
    Department of Virology, Royal Free and University College Medical School, Royal Free Campus, Rowland Hill Street, London NW3 2PF, UK
    J Clin Pathol 54:84-8. 2001
    b>Cytomegalovirus (CMV) is a recognised cause of morbidity and mortality in immunocompromised individuals...
  7. ncbi Epidermal growth factor receptor is a cellular receptor for human cytomegalovirus
    Xin Wang
    Lineberger Comprehensive Cancer Center, Department of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7295, USA
    Nature 424:456-61. 2003
    Human cytomegalovirus (HCMV) is a widespread opportunistic herpesvirus that causes severe and fatal diseases in immune-compromised individuals, including organ transplant recipients and individuals with AIDS...
  8. ncbi Genetic content of wild-type human cytomegalovirus
    Aidan Dolan
    MRC Virology Unit, Institute of Virology, Church Street, Glasgow G11 5JR, UK
    J Gen Virol 85:1301-12. 2004
    The genetic content of wild-type human cytomegalovirus was investigated by sequencing the 235 645 bp genome of a low passage strain (Merlin)...
  9. ncbi Platelet-derived growth factor-alpha receptor activation is required for human cytomegalovirus infection
    Liliana Soroceanu
    Department of Neurosciences, California Pacific Medical Center Research Institute, Suite 220, 475 Brannan Street, San Francisco, California 94107, USA
    Nature 455:391-5. 2008
    Human cytomegalovirus (HCMV) is a ubiquitous human herpesvirus that can cause life-threatening disease in the fetus and the immunocompromised host...
  10. ncbi Identification of proteins in human cytomegalovirus (HCMV) particles: the HCMV proteome
    Susan M Varnum
    Department of Molecular Microbiology and Immunology, Oregon Health Sciences University, Portland, OR 97201, USA
    J Virol 78:10960-6. 2004
    Human cytomegalovirus (HCMV), a member of the herpesvirus family, is a large complex enveloped virus composed of both viral and cellular gene products...
  11. ncbi HCMV microinfections in inflammatory diseases and cancer
    Cecilia Soderberg-Naucler
    Karolinska Insititutet, Center for Molecular Medicine, L8 03, Department of Medicine, Karolinska Hospital, SE 171 76 Stockholm, Sweden
    J Clin Virol 41:218-23. 2008
    Human cytomegalovirus (HCMV) is a wide-spread human virus that was mainly known to cause disease in immunocompromised patients...
  12. ncbi Human cytomegalovirus induces the interferon response via the DNA sensor ZBP1
    Victor R DeFilippis
    Oregon Health and Science University, Vaccine and Gene Therapy Institute, Beaverton, OR 97006, USA
    J Virol 84:585-98. 2010
    Human cytomegalovirus (HCMV) is a member of the betaherpesvirus family that, unlike other herpesviruses, triggers a strong innate immune response in infected cells that includes transcription of the beta interferon gene via activation of ..
  13. ncbi Coding potential of laboratory and clinical strains of human cytomegalovirus
    Eain Murphy
    Department of Molecular Biology, Princeton University, Princeton, NJ 80544, USA
    Proc Natl Acad Sci U S A 100:14976-81. 2003
    Six strains of human cytomegalovirus have been sequenced, including two laboratory strains (AD169 and Towne) that have been extensively passaged in fibroblasts and four clinical isolates that have been passaged to a limited extent in the ..
  14. ncbi Cytomegalovirus cell tropism
    C Sinzger
    Institute of Medical Virology, University of Tubingen, Elfriede Aulhorn Str 6, 72076 Tubingen, Germany
    Curr Top Microbiol Immunol 325:63-83. 2008
    The human cytomegalovirus (HCMV) can infect a remarkably broad cell range within its host, including parenchymal cells and connective tissue cells of virtually any organ and various hematopoietic cell types...
  15. ncbi Temporal dynamics of cytomegalovirus chromatin assembly in productively infected human cells
    Alexandra Nitzsche
    Institute for Medical Microbiology and Hygiene, University of Regensburg, Franz Josef Strauss Allee 11, 93053 Regensburg, Germany
    J Virol 82:11167-80. 2008
    The genomes of herpesviruses, including human cytomegalovirus (CMV), are double-stranded DNA molecules maintained as episomes during infection. The viral DNA lacks histones when encapsidated in the virion...
  16. ncbi Integrin alphavbeta3 is a coreceptor for human cytomegalovirus
    Xin Wang
    Lineberger Comprehensive Cancer Center, CB 7295, Lineberger Building, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Nat Med 11:515-21. 2005
    Human cytomegalovirus (HCMV) is a widespread opportunistic pathogen that causes birth defects in newborns and severe disease in immunocompromised individuals. The broad tropism of HCMV infection suggests that it uses multiple receptors...
  17. ncbi Human cytomegalovirus protein pp71 displaces the chromatin-associated factor ATRX from nuclear domain 10 at early stages of infection
    Vera Lukashchuk
    Medical Research Council Virology Unit, Church Street, Glasgow G11 5JR, Scotland, United Kingdom
    J Virol 82:12543-54. 2008
    The human cytomegalovirus (HCMV) tegument protein pp71, encoded by gene UL82, stimulates viral immediate-early (IE) transcription...
  18. ncbi Seroprevalence of cytomegalovirus infection in the United States, 1988-1994
    Stephanie A S Staras
    Department of Epidemiology, Emory University, Atlanta, GA 30322, USA
    Clin Infect Dis 43:1143-51. 2006
    b>Cytomegalovirus (CMV) is a leading cause of congenital illness and disability, including hearing loss and mental retardation...
  19. ncbi Evidence for a role of the cellular ND10 protein PML in mediating intrinsic immunity against human cytomegalovirus infections
    Nina Tavalai
    Institut für Klinische und Molekulare Virologie der Universität Erlangen Nürnberg, Schlossgarten 4, 91054 Erlangen, Germany
    J Virol 80:8006-18. 2006
    Several viruses, including human cytomegalovirus (HCMV), encode proteins that colocalize with a cellular subnuclear structure known as ND10...
  20. ncbi The human cytomegalovirus genome revisited: comparison with the chimpanzee cytomegalovirus genome
    Andrew J Davison
    MRC Virology Unit, Institute of Virology, Church Street, Glasgow G11 5JR, UK
    J Gen Virol 84:17-28. 2003
    The gene complement of wild-type human cytomegalovirus (HCMV) is incompletely understood, on account of the size and complexity of the viral genome and because laboratory strains have undergone deletions and rearrangements during ..
  21. ncbi Structural basis for translational stalling by human cytomegalovirus and fungal arginine attenuator peptide
    Shashi Bhushan
    Gene Center and Department of Biochemistry and Center for integrated Protein Science Munich, University of Munich, Feodor Lynen Strasse 25, 81377 Munich, Germany
    Mol Cell 40:138-46. 2010
    ..translation of two diverse regulatory peptides: the fungal arginine attenuator peptide (AAP) and the human cytomegalovirus (hCMV) gp48 upstream open reading frame 2 (uORF2)...
  22. ncbi Inactivating a cellular intrinsic immune defense mediated by Daxx is the mechanism through which the human cytomegalovirus pp71 protein stimulates viral immediate-early gene expression
    Ryan T Saffert
    Institute for Molecular Virology, and McArdle Laboratory for Cancer Research, University of Wisconsin--Madison, 1525 Linden Drive, Madison, Wisconsin 53706, USA
    J Virol 80:3863-71. 2006
    Human cytomegalovirus (HCMV) masterfully evades adaptive and innate immune responses, allowing infection to be maintained and periodically reactivated for the life of the host...
  23. ncbi Systems-level metabolic flux profiling identifies fatty acid synthesis as a target for antiviral therapy
    Joshua Munger
    Department of Molecular Biology, Lewis Thomas Laboratory, Princeton University, Princeton, New Jersey 08544, USA
    Nat Biotechnol 26:1179-86. 2008
    ..on liquid chromatography-tandem mass spectrometry to quantify changes in metabolic activity induced by human cytomegalovirus (HCMV)...
  24. ncbi Human cytomegalovirus glycoprotein B is required for virus entry and cell-to-cell spread but not for virion attachment, assembly, or egress
    Marisa K Isaacson
    McArdle Laboratory for Cancer Research, University of Wisconsin Madison Medical School, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    J Virol 83:3891-903. 2009
    ..Human cytomegalovirus (HCMV) gB (UL55) plays an essential role in the replication cycle of the virus...
  25. ncbi Nuclear domain 10 components promyelocytic leukemia protein and hDaxx independently contribute to an intrinsic antiviral defense against human cytomegalovirus infection
    Nina Tavalai
    Institut fur Klinische und Molekulare Virologie, University Hospital Erlangen, Schlossgarten 4, 91054 Erlangen, Germany
    J Virol 82:126-37. 2008
    ..like hDaxx or promyelocytic leukemia protein (PML), mediate an intrinsic immune response against human cytomegalovirus (HCMV) infection, strengthening the assumption that ND10 components are part of a cellular antiviral defense ..
  26. ncbi Cell-dependent interference of a series of new 6-aminoquinolone derivatives with viral (HIV/CMV) transactivation
    Miguel Stevens
    Rega Institute for Medical Research, Katholieke Universiteit Leuven, B 3000 Leuven, Belgium
    J Antimicrob Chemother 56:847-55. 2005
    ..These potent 6-aminoquinolones were further evaluated for their broad-spectrum antiviral properties...
  27. ncbi Epstein-Barr virus and cytomegalovirus in autoimmune diseases: are they truly notorious? A preliminary report
    O Barzilai
    Center for Autoimmune Diseases, Department of Medicine B, Sheba Medical Center, Tel Hashomer, Israel
    Ann N Y Acad Sci 1108:567-77. 2007
    ..Epstein-Barr virus (EBV) and cytomegalovirus (CMV) are considered to be notorious as they are consistently associated with multiple autoimmune diseases...
  28. ncbi Immunobiology of human cytomegalovirus: from bench to bedside
    Tania Crough
    Division of Immunology, Tumour Immunology Laboratory, Australian Centre for Vaccine Development, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Clin Microbiol Rev 22:76-98, Table of Contents. 2009
    SUMMARY: Following primary infection, human cytomegalovirus (HCMV) establishes lifelong latency and periodically reactivates without causing symptoms in healthy individuals...
  29. ncbi Vaccine prevention of maternal cytomegalovirus infection
    Robert F Pass
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham 35233, USA
    N Engl J Med 360:1191-9. 2009
    Congenital infection with cytomegalovirus (CMV) is an important cause of hearing, cognitive, and motor impairments in newborns.
  30. ncbi Human cytomegalovirus UL131-128 genes are indispensable for virus growth in endothelial cells and virus transfer to leukocytes
    Gabriele Hahn
    Max von Pettenkofer Institut, Abteilung Virologie, Ludwig Maximilians Universitat Munchen, Munich, Germany
    J Virol 78:10023-33. 2004
    Human cytomegalovirus (HCMV), a ubiquitous human pathogen, is the leading cause of birth defects and morbidity in immunocompromised patients and a potential trigger for vascular disease...
  31. ncbi Review and meta-analysis of the epidemiology of congenital cytomegalovirus (CMV) infection
    Aileen Kenneson
    National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Rev Med Virol 17:253-76. 2007
    We reviewed studies that reported results of systematic cytomegalovirus (CMV) screening on fetuses and/or live-born infants. The overall birth prevalence of congenital CMV infection was 0...
  32. ncbi The m74 gene product of murine cytomegalovirus (MCMV) is a functional homolog of human CMV gO and determines the entry pathway of MCMV
    Laura Scrivano
    Max von Pettenkofer Institut, Lehrstuhl Virologie, Feodor Lynen Strasse 25, D 81377 Munich, Germany
    J Virol 84:4469-80. 2010
    The glycoprotein gO (UL74) of human cytomegalovirus (HCMV) forms a complex with gH/gL...
  33. ncbi Inhibition of the NKp30 activating receptor by pp65 of human cytomegalovirus
    Tal I Arnon
    The Lautenberg Center for General and Tumor Immunology, The Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
    Nat Immunol 6:515-23. 2005
    Human cytomegalovirus, a chief pathogen in immunocompromised people, can persist in a healthy immunocompetent host throughout life without being eliminated by the immune system...
  34. ncbi Human Daxx-mediated repression of human cytomegalovirus gene expression correlates with a repressive chromatin structure around the major immediate early promoter
    David L Woodhall
    Department of Medicine, University of Cambridge, Cambridge CB2 2QQ, United Kingdom
    J Biol Chem 281:37652-60. 2006
    ..knockdown of human Daxx (hDaxx) expression, an important component of ND10, prior to infection with human cytomegalovirus resulted in increased levels of viral immediate early RNA and protein expression and that this correlated ..
  35. ncbi Alpha-(1-3)- and alpha-(1-6)-D-mannose-specific plant lectins are markedly inhibitory to human immunodeficiency virus and cytomegalovirus infections in vitro
    J Balzarini
    Laboratory of Chemotherapy, Rega Institute for Medical Research, Katholieke Universiteit Leuven, Belgium
    Antimicrob Agents Chemother 35:410-6. 1991
    ..however, the plant lectins did not inhibit the replication of other enveloped viruses, except for human cytomegalovirus (50% effective concentration, 0.9 to 1.6 microgram/ml)...
  36. ncbi Potent immunosuppressive activities of cytomegalovirus-encoded interleukin-10
    Juliet V Spencer
    ChemoCentryx, San Carlos, California 94070, USA
    J Virol 76:1285-92. 2002
    b>Cytomegalovirus (CMV) has highly evolved mechanisms for avoiding detection by the host immune system...
  37. ncbi Broadly targeted human cytomegalovirus-specific CD4+ and CD8+ T cells dominate the memory compartments of exposed subjects
    Andrew W Sylwester
    Vaccine and Gene Therapy Institute, Department of Pathology, Oregon Health and Science University, Beaverton, 97006, USA
    J Exp Med 202:673-85. 2005
    Human cytomegalovirus (HCMV) infections of immunocompetent hosts are characterized by a dynamic, life-long interaction in which host immune responses, particularly of T cells, restrain viral replication and prevent disease but do not ..
  38. ncbi Human cytomegalovirus glycoprotein UL16 causes intracellular sequestration of NKG2D ligands, protecting against natural killer cell cytotoxicity
    Claire Dunn
    Department of Molecular Microbiology and Immunology, Oregon Health and Sciences University, Portland, OR 97239, USA
    J Exp Med 197:1427-39. 2003
    ..The human cytomegalovirus (HCMV) membrane glycoprotein, UL16, binds to three of the five known ligands for human NKG2D...
  39. ncbi Role of the cellular protein hDaxx in human cytomegalovirus immediate-early gene expression
    Chris M Preston
    Medical Research Council Virology Unit, Glasgow, UK
    J Gen Virol 87:1113-21. 2006
    Human cytomegalovirus (HCMV) immediate-early (IE) transcription is stimulated by virion phosphoprotein pp71, the product of gene UL82...
  40. ncbi Proteasome-dependent, ubiquitin-independent degradation of Daxx by the viral pp71 protein in human cytomegalovirus-infected cells
    Jiwon Hwang
    Institute for Molecular Virology and McArdle Laboratory for Cancer Research, University of Wisconsin Madison, Madison, WI 53706, USA
    Virology 367:334-8. 2007
    The cellular Daxx protein represses human cytomegalovirus (HCMV) gene expression from the major immediate early promoter...
  41. ncbi Human cytomegalovirus encodes a highly specific RANTES decoy receptor
    Dai Wang
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Proc Natl Acad Sci U S A 101:16642-7. 2004
    The human cytomegalovirus pUL21.5 protein is a small, secreted glycoprotein whose mRNA is packaged into virions. We demonstrate that pUL21...
  42. ncbi Accelerated telomere shortening in leukocyte subpopulations of patients with coronary heart disease: role of cytomegalovirus seropositivity
    Ioakim Spyridopoulos
    Institute of Human Genetics, Newcastle University, International Centre for Life, Central Parkway, Newcastle upon Tyne NE13BZ, United Kingdom
    Circulation 120:1364-72. 2009
    ..Results were correlated to TL in CD34+ hematopoietic peripheral blood stem cells and progenitor cells obtained from the same individual patients...
  43. ncbi Hierarchical and redundant lymphocyte subset control precludes cytomegalovirus replication during latent infection
    B Polic
    Department of Histology and Embryology, Faculty of Medicine, University of Rijeka, Croatia
    J Exp Med 188:1047-54. 1998
    Reactivation from latent cytomegalovirus (CMV) infection is often associated with conditions of immunosuppression and can result in fatal disease...
  44. ncbi Cytomegalovirus and human immunosenescence
    Graham Pawelec
    Center for Medical Research, University of Tubingen Medical School, Tubingen, Germany
    Rev Med Virol 19:47-56. 2009
    ..Whether the IRP is informative in younger individuals and the mechanism of the CMV effect is discussed in this review...
  45. ncbi Receptors and immune sensors: the complex entry path of human cytomegalovirus
    Teresa Compton
    McArdle Laboratory for Cancer Research, 1400 University Avenue, Madison, WI 53706, USA
    Trends Cell Biol 14:5-8. 2004
    The ability of human cytomegalovirus (HCMV) to infect an extensive range of cell types has complicated efforts to identify cellular receptors for this significant pathogen...
  46. ncbi Epidermal growth factor receptor is not required for human cytomegalovirus entry or signaling
    Marisa K Isaacson
    McArdle Laboratory for Cancer Research, University of Wisconsin Madison Medical School 53706, USA
    J Virol 81:6241-7. 2007
    Human cytomegalovirus (HCMV) can bind, fuse, and initiate gene expression in a diverse range of vertebrate cell types...
  47. ncbi Coiled-coil domains in glycoproteins B and H are involved in human cytomegalovirus membrane fusion
    Matthew Lopper
    Department of Biomolecular Chemistry, University of Wisconsin-Madison, Madison, WI 53706, USA
    J Virol 78:8333-41. 2004
    Human cytomegalovirus (CMV) utilizes a complex route of entry into cells that involves multiple interactions between viral envelope proteins and cellular receptors...
  48. ncbi Isolation of human monoclonal antibodies that potently neutralize human cytomegalovirus infection by targeting different epitopes on the gH/gL/UL128-131A complex
    Annalisa Macagno
    Institute for Research in Biomedicine, Via Vincenzo Vela 6, CH 6500 Bellinzona, Switzerland
    J Virol 84:1005-13. 2010
    Human cytomegalovirus (HCMV) is a widely circulating pathogen that causes severe disease in immunocompromised patients and infected fetuses...
  49. ncbi Chromatin structure regulates human cytomegalovirus gene expression during latency, reactivation and lytic infection
    John Sinclair
    Department of Medicine, Level 5, Addenbrooke s Hospital, University of Cambridge, Hills Rd, Cambridge CB22QQ, UK
    Biochim Biophys Acta 1799:286-95. 2010
    Infection of cells with human cytomegalovirus (HCMV) has two potential outcomes. For instance, infection of fibroblasts results in extensive viral gene expression, viral DNA replication and release of progeny virus...
  50. ncbi Altered cellular mRNA levels in human cytomegalovirus-infected fibroblasts: viral block to the accumulation of antiviral mRNAs
    E P Browne
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544-1014, USA
    J Virol 75:12319-30. 2001
    The effect of human cytomegalovirus (HCMV) infection on cellular mRNA accumulation was analyzed by gene chip technology...
  51. ncbi Human cytomegalovirus activates glucose transporter 4 expression to increase glucose uptake during infection
    Yongjun Yu
    Department of Cancer Biology, Abramson Family Cancer Research Institute, University of Pennsylvania, School of Medicine, Philadelphia, Pennsylvania 19104 6142, USA
    J Virol 85:1573-80. 2011
    ..Human cytomegalovirus (HCMV)-infected human fibroblasts (HFs) demonstrate significantly increased glucose consumption compared to ..
  52. ncbi Entry route of HCMV into endothelial cells
    Christian Sinzger
    Institut fur Medizinische Virologie, Eberhard Karls Universitat, Tubingen, Germany
    J Clin Virol 41:174-9. 2008
    Human cytomegalovirus (HCMV) is generally assumed to enter its target cells by direct fusion at the plasma membrane while sequestration and lysis of viral particles within endocytic vesicles has been suggested as an abortive entry ..
  53. ncbi Cellular integrins function as entry receptors for human cytomegalovirus via a highly conserved disintegrin-like domain
    Adam L Feire
    McArdle Laboratory for Cancer Research, University of Wisconsin, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 101:15470-5. 2004
    Human cytomegalovirus (HCMV) is capable of manifesting disease in nearly every organ system in immunocompromised patients...
  54. ncbi Natural killer cell-mediated response to human cytomegalovirus-infected macrophages is modulated by their functional polarization
    Neus Romo
    Immunology Unit, Pompeu Fabra University, Barcelona, Spain
    J Leukoc Biol 90:717-26. 2011
    ..MΦ may be infected by human cytomegalovirus (HCMV), which has evolved different strategies to subvert the immune response...
  55. ncbi Human cytomegalovirus uses two distinct pathways to enter retinal pigmented epithelial cells
    Dai Wang
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Proc Natl Acad Sci U S A 104:20037-42. 2007
    Human cytomegalovirus infects multiple cell types, including fibroblasts and epithelial cells. It penetrates fibroblasts by fusion at the cell surface but is endocytosed into epithelial cells...
  56. ncbi Cytomegalovirus infection and the risk of mortality and frailty in older women: a prospective observational cohort study
    George C Wang
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
    Am J Epidemiol 171:1144-52. 2010
    b>Cytomegalovirus (CMV), a prevalent pathogen, causes severe disease in immunocompromised humans. However, present understanding is limited regarding the long-term clinical effect of persistent CMV infection in immunocompetent adults...
  57. ncbi Human cytomegalovirus retinitis: pathogenicity, immune evasion and persistence
    Martin Scholz
    Zentrum der Hygiene, , , Paul-Ehrlich-Strasse 40, D-60596 Frankfurt am Main, Germany
    Trends Microbiol 11:171-8. 2003
    Human cytomegalovirus (HCMV) retinitis frequently occurs in severely naturally and iatrogenically immunocompromised patients...
  58. ncbi Granulocyte-colony stimulating factor reactivates human cytomegalovirus in a latently infected humanized mouse model
    M Shane Smith
    Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, OR 97006, USA
    Cell Host Microbe 8:284-91. 2010
    Human cytomegalovirus (HCMV) is a significant cause of morbidity and mortality in organ transplant recipients...
  59. ncbi Cytomegalovirus reactivation in critically ill immunocompetent patients
    Ajit P Limaye
    Department of Laboratory Medicine, University of Washington Medical Center, 1959 NE Pacific St, Seattle, WA 98195 7110, USA
    JAMA 300:413-22. 2008
    b>Cytomegalovirus (CMV) infection is associated with adverse clinical outcomes in immunosuppressed persons, but the incidence and association of CMV reactivation with adverse outcomes in critically ill persons lacking evidence of ..
  60. ncbi Human cytomegalovirus immediate early proteins and cell growth control
    Jonathan P Castillo
    Program in Immunology and Virology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Gene 290:19-34. 2002
    ..between the functions of the major immediate early (IE) proteins of at least one herpesvirus, human cytomegalovirus (HCMV) and IE equivalents encoded by small DNA tumor viruses, such as adenovirus...
  61. ncbi Characterization of the human cytomegalovirus gH/gL/UL128-131 complex that mediates entry into epithelial and endothelial cells
    Brent J Ryckman
    6366 Basic Sciences Building, Mail Code L 220, Department of Molecular Microbiology and Immunology, Oregon Health and Sciences University, 3181 Sam Jackson Park Rd, Portland, OR 97239, USA
    J Virol 82:60-70. 2008
    The entry of human cytomegalovirus (HCMV) into biologically relevant epithelial and endothelial cells involves endocytosis followed by low-pH-dependent fusion...
  62. ncbi Cytomegalovirus infection in Gambian infants leads to profound CD8 T-cell differentiation
    David J C Miles
    MRC Laboratories Gambia, P O Box 273, Banjul, The Gambia
    J Virol 81:5766-76. 2007
    b>Cytomegalovirus (CMV) infection is endemic in Gambian infants, with 62% infected by 3 months and 85% by 12 months of age. We studied the CD8 T-cell responses of infants to CMV following primary infection...
  63. ncbi Cloning and sequencing of a highly productive, endotheliotropic virus strain derived from human cytomegalovirus TB40/E
    Christian Sinzger
    Institut fur Medizinische Virologie, Eberhard Karls Universitat, Tubingen, Germany
    J Gen Virol 89:359-68. 2008
    Human cytomegalovirus (HCMV) strain TB40/E, replicates efficiently, exhibits a broad cell tropism and is widely used for infection of endothelial cells and monocyte-derived cells yet has not been available in a phenotypically homogeneous ..
  64. ncbi The story of human cytomegalovirus and cancer: increasing evidence and open questions
    Martin Michaelis
    Institut fur Medizinische Virologie, Klinikum der Johann Wolfgang Goethe Universitat, Frankfurt am Main, Germany
    Neoplasia 11:1-9. 2009
    Although human cytomegalovirus (HCMV) is generally not regarded to be an oncogenic virus, HCMV infection has been implicated in malignant diseases from different cancer entities...
  65. ncbi Lentiviral vectors with CMV or MHCII promoters administered in vivo: immune reactivity versus persistence of expression
    Takahiro Kimura
    Department of Medicine, Division of Digestive Diseases, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California, USA
    Mol Ther 15:1390-9. 2007
    ..Control vectors contained the ubiquitous cytomegalovirus (CMV) promoter...
  66. ncbi Human cytomegalovirus-encoded interleukin-10 homolog inhibits maturation of dendritic cells and alters their functionality
    W L William Chang
    Center for Comparative Medicine, University of California, Davis, County Road 98 and Hutchison Drive, Davis, CA 95616, USA
    J Virol 78:8720-31. 2004
    ..We hypothesized that human cytomegalovirus (HCMV) utilizes its viral IL-10 homolog (cmvIL-10) to attenuate DC functionality, thereby subverting the ..
  67. ncbi Sequential mutations associated with adaptation of human cytomegalovirus to growth in cell culture
    Derrick J Dargan
    MRC Virology Unit, Institute of Virology, University of Glasgow, Church Street, Glasgow G11 5JR, UK
    J Gen Virol 91:1535-46. 2010
    Mutations that occurred during adaptation of human cytomegalovirus to cell culture were monitored by isolating four strains from clinical samples, passaging them in various cell types and sequencing ten complete virus genomes from the ..
  68. ncbi Bcl-3-regulated transcription from major immediate-early promoter of human cytomegalovirus in monocyte-derived macrophages
    Kashif Aziz Khan
    Department of Virology, Institut Fédératif de Recherche 133, Equipe d Accueil 3186, Franche Comte University, Centre Hospitalier Universitaire de Besancon, Besancon, France
    J Immunol 182:7784-94. 2009
    ..Thus, activation of p52/Bcl-3 complexes in MDMs and p50/p65 heterodimers in fibroblasts in response to HCMV infection might explain the low-level growth of the virus in MDMs vs efficient growth in fibroblasts...
  69. ncbi Detection of herpes simplex virus, cytomegalovirus, and Epstein-Barr virus in the semen of men attending an infertility clinic
    Nikiforos Kapranos
    Division of Molecular Pathology, Department of Pathology, Amalia Fleming Hospital, Athens, Greece
    Fertil Steril 79:1566-70. 2003
    To investigate the prevalence of herpes simplex virus (HSV), cytomegalovirus (CMV), and Epstein-Barr virus (EBV) in the semen of men with fertility problems.
  70. ncbi Human cytomegalovirus virion protein complex required for epithelial and endothelial cell tropism
    Dai Wang
    Department of Molecular Biology, Princeton University, NJ 08544, USA
    Proc Natl Acad Sci U S A 102:18153-8. 2005
    Human cytomegalovirus replicates in many different cell types, including epithelial cells, endothelial cells, and fibroblasts...
  71. ncbi Could an infectious trigger explain the differential maternal response to the shared placental pathology of preeclampsia and normotensive intrauterine growth restriction?
    Peter von Dadelszen
    Department of Obstetrics and Gynaecology, Children s and Women s Health Centre of British Columbia and University of British Columbia, Vancouver, British Columbia, Canada
    Acta Obstet Gynecol Scand 81:642-8. 2002
    ..Also reviewed is the human and animal model evidence for an infectious trigger for preeclampsia. Perhaps preeclampsia truly is the 'toxemia' of pregnancy...
  72. ncbi Human cytomegalovirus infection activates and regulates the unfolded protein response
    Jennifer A Isler
    Department of Cancer Biology, Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, USA
    J Virol 79:6890-9. 2005
    ..We demonstrate that human cytomegalovirus (HCMV) infection induces the UPR but specifically regulates the three branches of UPR signaling, PKR-like ER ..
  73. ncbi Cytomegalovirus antibody levels, inflammation, and mortality among elderly Latinos over 9 years of follow-up
    Eric T Roberts
    Department of Epidemiology, 3659 SPH Tower, 109 Observatory, Ann Arbor, MI 48104 2548, USA
    Am J Epidemiol 172:363-71. 2010
    This study examined the relation between immune response to cytomegalovirus (CMV) and all-cause and cardiovascular disease (CVD) mortality, and possible mediating mechanisms...
  74. ncbi Prevalence, risk factors, and impact on outcome of cytomegalovirus replication in serum of Cambodian HIV-infected patients (2004-2007)
    Romain Micol
    Unité d Epidémiologie des Maladies Emergentes, Institut Pasteur, Paris, France
    J Acquir Immune Defic Syndr 51:486-91. 2009
    In developing countries, the study of cytomegalovirus (CMV) coinfection in HIV-infected patients remains neglected...
  75. ncbi Rhesus CMV: an emerging animal model for human CMV
    Colin Powers
    Vaccine and Gene Therapy Institute, Oregon Health and Science University, 505 NW 185th Ave, Beaverton, OR 97006, USA
    Med Microbiol Immunol 197:109-15. 2008
    ..In this review we will discuss the current state of developing RhCMV as a model for HCMV...
  76. ncbi Chronic herpesvirus reactivation occurs in aging
    Raymond P Stowe
    Department of Pathology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555, United States
    Exp Gerontol 42:563-70. 2007
    ..expansions of CD8+ T cells of which a substantial portion are directed against Epstein-Barr virus (EBV) and cytomegalovirus (CMV)...
  77. ncbi High prevalence of human cytomegalovirus in prostatic intraepithelial neoplasia and prostatic carcinoma
    Minu Samanta
    Surgical Service, Veterans Affairs Medical Center, University of Alabama at Birmingham, Birmingham, AL, USA
    J Urol 170:998-1002. 2003
    ..Human cytomegalovirus (HCMV) is a member of the herpesvirus family, is sexually transmitted in adults and can persistently infect ..
  78. ncbi Expression and function of NKG2D in CD4+ T cells specific for human cytomegalovirus
    Andrea Sáez-Borderías
    Molecular Immunopathology Unit, Universitat Pompeu Fabra DCEXS, Barcelona, Spain
    Eur J Immunol 36:3198-206. 2006
    ..In the present study, we analysed NKG2D expression in human cytomegalovirus (HCMV)-specific CD4(+) T lymphocytes...
  79. ncbi Human cytomegalovirus: clinical aspects, immune regulation, and emerging treatments
    Maher K Gandhi
    Tumour Immunology Laboratory at the Queensland Institute of Medical Research, Brisbane, Australia
    Lancet Infect Dis 4:725-38. 2004
    After initial infection, human cytomegalovirus remains in a persistent state with the host...
  80. ncbi Chromatinisation of herpesvirus genomes
    Christina Paulus
    Institute for Medical Microbiology and Hygiene, University of Regensburg, 93053 Regensburg, Germany
    Rev Med Virol 20:34-50. 2010
    ..similarities in nucleosome assembly and disassembly processes on herpes simplex virus type 1 and human cytomegalovirus genomes over the course of the viral productive replication cycle and during the switch between latent and ..
  81. ncbi Transcriptome analysis reveals human cytomegalovirus reprograms monocyte differentiation toward an M1 macrophage
    Gary Chan
    Department of Microbiology and Immunology, Center for Molecular and Tumor Virology, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA
    J Immunol 181:698-711. 2008
    ..Overall, the results identify that the HCMV-infected monocyte transcriptome displayed a unique M1/M2 polarization signature that was skewed toward the classical M1 activation phenotype...
  82. ncbi The human cytomegalovirus microRNA miR-UL112 acts synergistically with a cellular microRNA to escape immune elimination
    Daphna Nachmani
    The Lautenberg Center for General and Tumor Immunology, The BioMedical Research Institute Israel Canada of the Faculty of Medicine, The Hebrew University Hadassah Medical School, Jerusalem, Israel
    Nat Immunol 11:806-13. 2010
    ..Moreover, we demonstrate that through site proximity and possibly inhibition of translation, a human cytomegalovirus (HCMV) microRNA acts synergistically with a cellular microRNA to suppress MICB expression during HCMV ..
  83. ncbi Biomarkers of human immunosenescence: impact of Cytomegalovirus infection
    Evelyna Derhovanessian
    Center for Medical Research, ZMF, University of Tubingen Medical School, Tubingen, Germany
    Curr Opin Immunol 21:440-5. 2009
    ..at many years ago, a marked impact of usually asymptomatic infection with the persistent beta-herpesvirus Cytomegalovirus (CMV) on markers of immunosenescence is now becoming incontrovertible...
  84. ncbi Human cytomegalovirus UL131 open reading frame is required for epithelial cell tropism
    Dai Wang
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544-1014, USA
    J Virol 79:10330-8. 2005
    Epithelial cells are one of the prominent cell types infected by human cytomegalovirus (HCMV) within its host...
  85. ncbi Feeling manipulated: cytomegalovirus immune manipulation
    Mindy Miller-Kittrell
    Department of Microbiology, University of Tennessee, 1414 Cumberland Ave, Knoxville, TN, USA
    Virol J 6:4. 2009
    No one likes to feel like they have been manipulated, but in the case of cytomegalovirus (CMV) immune manipulation, we do not really have much choice...
  86. ncbi Specific localisation of human cytomegalovirus nucleic acids and proteins in human colorectal cancer
    Lualhati Harkins
    Pathology Service, Birmingham Veterans Affairs Hospital, Birmingham, AL, USA
    Lancet 360:1557-63. 2002
    ..Human cytomegalovirus is a beta-herpesvirus that is endemic in the human population and can cause life-threatening disease in ..
  87. ncbi Rapid CD8+ T cell repertoire focusing and selection of high-affinity clones into memory following primary infection with a persistent human virus: human cytomegalovirus
    Elizabeth K Day
    Department of Medicine, School of Clinical Medicine, Addenbrookes Hospital, Hills Road, Cambridge, United Kingdom
    J Immunol 179:3203-13. 2007
    ..Thus, the oligoclonal T cell repertoire against an immunodominant persistent viral epitope is established early in primary infection by the rapid selection of public clonotypes, rather than being a stochastic process...
  88. ncbi A novel link between stress and human cytomegalovirus (HCMV) infection: sympathetic hyperactivity stimulates HCMV activation
    S Prosch
    Department of Medical Virology, Humboldt University, Berlin, D 10098, Germany
    Virology 272:357-65. 2000
    Recently, inflammatory mediators such as TNFalpha were identified as triggering active human cytomegalovirus (HCMV) infection...
  89. ncbi Socioeconomic differentials in immune response
    Jennifer Beam Dowd
    Hunter College, School of Health Sciences, City University of New York CUNY, New York, NY, USA
    Epidemiology 20:902-8. 2009
    ..Here we test whether SES is related to cell-mediated immunity, as measured by the host's ability to keep persistent cytomegalovirus (CMV) antibody levels in a quiescent state.
  90. ncbi Shaping phenotype, function, and survival of dendritic cells by cytomegalovirus-encoded IL-10
    Martin J Raftery
    Institute of Virology, , Berlin, Germany
    J Immunol 173:3383-91. 2004
    ..Taken together, these findings show potential mechanisms by which cmvIL-10 could assist HCMV to infect DCs and to impair DC function and survival...
  91. ncbi Human cytomegalovirus entry into epithelial and endothelial cells depends on genes UL128 to UL150 and occurs by endocytosis and low-pH fusion
    Brent J Ryckman
    Department of Molecular Microbiology and Immunology, Oregon Health and Sciences University, 3181 Sam Jackson Park Rd, Portland, OR 97239, USA
    J Virol 80:710-22. 2006
    Human cytomegalovirus (HCMV) replication in epithelial and endothelial cells appears to be important in virus spread, disease, and persistence...
  92. ncbi Construction of a self-excisable bacterial artificial chromosome containing the human cytomegalovirus genome and mutagenesis of the diploid TRL/IRL13 gene
    Dong Yu
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544-1014, USA
    J Virol 76:2316-28. 2002
    The full-length genome of human cytomegalovirus strain AD169 was cloned as an infectious bacterial artificial chromosome (BAC) plasmid, pAD/Cre...
  93. ncbi Cytomegalovirus-related complications in human hand transplantation
    Stefan Schneeberger
    Department of General and Transplant Surgery, Innsbruck Medical University, Innsbruck, Austria
    Transplantation 80:441-7. 2005
    BACKGROUND: Up to date, 24 hands/thumbs have been transplanted in 18 patients. We herein report on cytomegalovirus (CMV) infection, disease, and the adopted treatment...
  94. ncbi Cytomegalovirus DNAemia and disease: incidence, natural history and management in settings other than allogeneic stem cell transplantation
    Ashley P Ng
    Division of Hematology and Medical Oncology, Peter MacCallum Cancer Centre and University of Melbourne, Melbourne, Victoria, Australia
    Haematologica 90:1672-9. 2005
    ..and profound immunosuppression associated with newer therapies for hematologic malignancies, little information exists regarding cytomegalovirus (CMV) reactivation in settings other than allogeneic stem cell transplantation (SCT).
  95. ncbi Cytomegalovirus: occurrence, severity, and effect on graft survival in simultaneous pancreas-kidney transplantation
    Maria Jose Ricart
    Renal Transplant Unit, University of Barcelona, Spain
    Nephrol Dial Transplant 20:ii25-ii32, ii62. 2005
    This analysis of the Euro-SPK 001 study examined the occurrence and effect of cytomegalovirus (CMV) infection during the first 3 years after simultaneous pancreas-kidney (SPK) transplantation.
  96. ncbi Follow-up of 28 HCMV seropositive renal-transplant recipients: comparison of clinical, biological and virological parameters in the groups of treated versus untreated infected patients
    Nassim Kamar
    , , CHU Toulouse, Toulouse, France
    J Clin Virol 33:35-42. 2005
    BACKGROUND: A pre-emptive strategy for prevention of Human Cytomegalovirus (HCMV) disease depends on accurate detection of HCMV infection and clinical and/or biological abnormalities...
  97. ncbi A simplified strategy for clinical management of late cytomegalovirus infection after oral ganciclovir prophylaxis in renal recipients
    Dirk R J Kuypers
    Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Herestraat 49, B 3000 Leuven, Belgium
    J Antimicrob Chemother 55:391-4. 2005
    Late cytomegalovirus disease after completion of prophylactic therapy occurs in 5-21% of renal allograft recipients within the first year post-transplantation...
  98. ncbi Rapid quantitative analysis of human cytomegalovirus DNA by the real-time polymerase chain reaction method
    Sanae Numata
    First Department of Pathology, Kurume University School of Medicine, Kurume shi, Fukuoka, Japan
    Arch Pathol Lab Med 129:200-4. 2005
    Human cytomegalovirus (CMV) infection is a progressive and life-threatening complication in immunocompromised patients even now...
  99. ncbi Quantitative PCR in the diagnosis of CMV infection and in the monitoring of viral load during the antiviral treatment in renal transplant patients
    H Piiparinen
    Department of Virology, Helsinki University Central Hospital and Helsinki University, Helsinki, Finland
    J Med Virol 76:367-72. 2005
    b>Cytomegalovirus (CMV) infection is a significant problem in transplantation...
  100. ncbi [Ganciclovir treatment of congenital cytomegalovirus infection]
    Agnes Till
    , , , Gyermekklinika,
    Orv Hetil 147:609-12. 2006
    The authors present the cases of two infants with congenital cytomegalovirus infection, who to the best of the authors' knowledge were the first ones to receive ganciclovir treatment in Hungary...
  101. ncbi Once daily ganciclovir as initial pre-emptive therapy delayed until threshold CMV load > or =10000 copies/ml: a safe and effective strategy for allogeneic stem cell transplant patients
    L A Verkruyse
    Section of Bone Marrow Transplantation and Leukemia, Washington University School of Medicine, St Louis, MO 63110, USA
    Bone Marrow Transplant 37:51-6. 2006
    Quantitative polymerase chain reaction (QPCR) for cytomegalovirus (CMV) is emerging as the preferred screening method for detection of CMV viremia in patients following allogeneic bone marrow and peripheral blood stem cell transplant...

Research Grants93

  1. CYTOMEGALOVIRUS DNA REPLICATION AND INVERSION
    Edward Mocarski; Fiscal Year: 1991
    ..circularization, inversion and cleavage/packaging of herpesviruses with emphasis on a beta herpesvirus, human cytomegalovirus (CMV)...
  2. Ribozymes for studies and treatment of cytomegalovirus infections
    Fenyong Liu; Fiscal Year: 2009
    Human cytomegalovirus (HCMV) causes one of the most common opportunistic infections in patients with AIDS...
  3. Ribozymes for studies and treatment of cytomegalovirus infections
    Fenyong Liu; Fiscal Year: 2010
    Human cytomegalovirus (HCMV) causes one of the most common opportunistic infections in patients with AIDS...
  4. T CELLS IN LUNG INFLAMMATION
    Peter Kao; Fiscal Year: 2000
    ..involving activated T-cells is a feature of asthma, hypersensitivity pneumonitis, sarcoidosis and Cytomegalovirus-associated interstitial pneumonitis following organ transplantation...
  5. CD8+ T Cell Immunity to Cytomegalovirus
    Stanley R Riddell; Fiscal Year: 2010
    Reactivation of latent cytomegalovirus (CMV) occurs frequently in immunosuppressed recipients of allogeneic hematopoietic stem cell transplant (HCT) as a consequence of deficient T cell immunity, and is responsible for substantial ..
  6. Virologic and Immunologic Studies of Murine CMV Retinitis
    Sally Atherton; Fiscal Year: 2009
    The incidence of cytomegalovirus retinitis has decreased in human immunodeficiency virus (HIV)-infected patients concomitant with the widespread use of highly actively antiretroviral therapy (HAART)...
  7. Virologic and Immunologic Studies of Murine CMV Retinitis
    Sally S Atherton; Fiscal Year: 2010
    The incidence of cytomegalovirus retinitis has decreased in human immunodeficiency virus (HIV)-infected patients concomitant with the widespread use of highly actively antiretroviral therapy (HAART)...
  8. Defense Mechanisms Against CMV Brain Infection
    JAMES LOKENSGARD; Fiscal Year: 2007
    b>Cytomegalovirus is a significant opportunistic pathogen in AIDS patients as well as the most common infectious cause of congenital brain disorders...
  9. CYTOMEGALOVIRUS PATHOGENESIS IN IMMUNODEFICIENCY
    Edward Mocarski; Fiscal Year: 1993
    b>Cytomegalovirus Pathogenesis Immunodeficiency Human cytomegalovirus (CMV) is a major pathogen affecting the developing fetus and immunocompromised individuals...
  10. Human Cytomegalovirus-Induced Inhibition of Cytotrophoblast Invasion
    CINDY ANNE MORRIS; Fiscal Year: 2010
    ..morbidity and mortality is associated with symptomatic congenital infection with the herpes virus human cytomegalovirus (HCMV)...
  11. Human Cytomegalovirus-Induced Inhibition of Cytotrophoblast Invasion
    Cindy Morris; Fiscal Year: 2009
    ..morbidity and mortality is associated with symptomatic congenital infection with the herpes virus human cytomegalovirus (HCMV)...
  12. Human Cytomegalovirus-Induced Inhibition of Cytotrophoblast Invasion
    Cindy Morris; Fiscal Year: 2009
    ..morbidity and mortality is associated with symptomatic congenital infection with the herpes virus human cytomegalovirus (HCMV)...
  13. Cytomegalovirus infection of blood vessels
    Fenyong Liu; Fiscal Year: 2005
    Human cytomegalovirus (HCMV) causes one of the most common opportunistic infections in immunocompromised individuals, including organ transplant recipients and AIDS patients...
  14. Ab Alphavirus Replicon Vaccine against Cytomegalovirus
    Robert Esch; Fiscal Year: 2005
    ..of the proposed research are to develop further an alphavirus replicon particle vaccine against human cytomegalovirus (CMV)...
  15. Novel 3-D Model of Placental Cytomegalovirus Infection
    Cindy Morris; Fiscal Year: 2006
    The overall objective of this proposal is to develop an improved tissue model for the study of human cytomegalovirus infection (CMV) during pregnancy...
  16. MOLECULAR STUDIES OF HUMAN CYTOMEGALOVIRUS PROTEASE
    Liang Tong; Fiscal Year: 2003
    DESCRIPTION: (Adapted from Applicant's Abstract) Human cytomegalovirus (HCMV), a herpesvirus, is a major opportunistic infectious agent in individuals suffering from AIDS, as well as individuals with suppressed immune systems (for ..
  17. Defense Mechanisms Against CMV Brain Infection
    James R Lokensgard; Fiscal Year: 2010
    Human cytomegalovirus is an opportunistic pathogen that produces a devastating central nervous system disease in AIDS patients and is the most common infectious cause of congenital brain disorders...
  18. A Non-Human Primate Model for Cytomegalovirus Vaccines
    Peter Barry; Fiscal Year: 2005
    There are no licensed vaccines for human cytomegalovirus (HCMV). Limited clinical trials have been conducted with live attenuated and recombinant subunit vaccines...
  19. Cytomegalovirus Chemokine Receptors in Transplant Vascular Sclerosis
    Susan Orloff; Fiscal Year: 2009
    ..Clinical studies have directly associated human cytomegalovirus (HCMV) with the acceleration of TVS and vascular restenosis following angioplasty, as well as atherosclerosis...
  20. A POTENT ORAL THERAPY FOR CYTOMEGALOVIRUS INFECTION
    Terry Bowlin; Fiscal Year: 2006
    Human cytomegalovirus (HCMV) infections continue to represent a major health concern in the immunocompromised population, especially recipients of bone marrow and solid-organ transplants...
  21. A CONGENITAL CYTOMEGALOVIRUS MODEL OF AUDITORY PATHOLOGY
    NIGEL WOOLF; Fiscal Year: 1993
    b>Cytomegalovirus (CMV) is the leading cause of nonhereditary, congenital deafness. CMV is also recognized as the most common cause of human congenital infection, occurring in up to 2.5% of all live births...
  22. ENVELOPE ASSEMBLY OF HUMAN CYTOMEGALOVIRUS
    WILLIAM JARVIS BRITT; Fiscal Year: 2010
    ..In contrast, the assembly of the (3-herpesviruses, human cytomegalovirus (HCMV), is less well understood and appears to differ from that of a-herpesviruses in several respects...
  23. ENVELOPE ASSEMBLY OF HUMAN CYTOMEGALOVIRUS
    William Britt; Fiscal Year: 2007
    ..In contrast, the assembly of the (3-herpesviruses, human cytomegalovirus (HCMV), is less well understood and appears to differ from that of a-herpesviruses in several respects...
  24. CYTOMEGALOVIRUS DNA REPLICATION AND RECOMBINATION
    Edward Mocarski; Fiscal Year: 1993
    This proposal aims to understand the process and functions involved in cytomegalovirus DNA replication...
  25. VACCINES FOR PREVENTION OF EXPERIMENTAL CONGENITAL CMV
    Mark Schleiss; Fiscal Year: 2003
    Human cytomegalovirus (HCMV) is an important pathogen which causes severe morbidity in immunocompromised individuals, including newborn infants...
  26. Human cytomegalovirus alkaline nuclease (pUL98): potential antiviral target?
    Michael McVoy; Fiscal Year: 2007
    Human cytomegalovirus (HCMV), a member of the herpesviridae family of viruses, is a significant human pathogen, causing pneumonitis, blindness, and death among transplant and AIDS patients and mental retardation and hearing loss among ..
  27. Cytomegalovirus virulence in immunodeficient hosts
    Fenyong Liu; Fiscal Year: 2011
    Human cytomegalovirus (HCMV) is one of the most common opportunistic infectious agents in AIDS patients...
  28. Cytomegalovirus virulence in immunodeficient hosts
    Fenyong Liu; Fiscal Year: 2010
    Human cytomegalovirus (HCMV) is one of the most common opportunistic infectious agents in AIDS patients...
  29. DEFENSE MECHANISMS FOR CYTOMEGALOVIRUS BRAIN INFECTION
    JAMES LOKENSGARD; Fiscal Year: 2003
    ..to study the relevance of CD8+ T cell mediated, non-cytotoxic and non-MHC-mediated suppression of human cytomegalovirus infection in human brain...
  30. HUMAN CYTOMEGALOVIRUS DNA CLEAVAGE AND PACKAGING
    Michael McVoy; Fiscal Year: 2005
    ..simplex virus, varicella-zoster virus, Epstein-Barr virus, Kaposi's sarcoma associated herpesvirus, and human cytomegalovirus (HCMV)...