cytomegalovirus

Summary

Summary: A genus of the family HERPESVIRIDAE, subfamily BETAHERPESVIRINAE, infecting the salivary glands, liver, spleen, lungs, eyes, and other organs, in which they produce characteristically enlarged cells with intranuclear inclusions. Infection with Cytomegalovirus is also seen as an opportunistic infection in AIDS.

Top Publications

  1. ncbi Host immune system gene targeting by a viral miRNA
    Noam Stern-Ginossar
    Lautenberg Center for General and Tumor Immunology, Hebrew University Hadassah Medical School, Jerusalem, Israel
    Science 317:376-81. 2007
  2. pmc Seropositivity to cytomegalovirus, inflammation, all-cause and cardiovascular disease-related mortality in the United States
    Amanda M Simanek
    Department of Epidemiology, Center for Social Epidemiology and Population Health, School of Public Health, University of Michigan, Ann Arbor, Michigan, United States of America
    PLoS ONE 6:e16103. 2011
  3. pmc Experimental human cytomegalovirus latency in CD14+ monocytes
    Danna Hargett
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544 1014, USA
    Proc Natl Acad Sci U S A 107:20039-44. 2010
  4. ncbi Human cytomegalovirus directly induces the antiviral protein viperin to enhance infectivity
    Jun Young Seo
    Department of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine, 300 Cedar Street, New Haven, CT 06520 8011, USA
    Science 332:1093-7. 2011
  5. pmc Dynamics of the cellular metabolome during human cytomegalovirus infection
    Joshua Munger
    Department of Molecular Biology, Princeton University, Princeton, New Jersey, United States of America
    PLoS Pathog 2:e132. 2006
  6. pmc Human cytomegalovirus activates inflammatory cytokine responses via CD14 and Toll-like receptor 2
    Teresa Compton
    McArdle Laboratory for Cancer Research, University of Wisconsin Madison Medical School, Madison, Wisconsin 53706, USA
    J Virol 77:4588-96. 2003
  7. pmc Human CD4+ CD25+ regulatory T cells control T-cell responses to human immunodeficiency virus and cytomegalovirus antigens
    Einar M Aandahl
    Gladstone Institute of Virology and Immunology, University of California San Francisco, San Francisco, California 94110, USA
    J Virol 78:2454-9. 2004
  8. pmc Human cytomegalovirus induces the activity and expression of acetyl-coenzyme A carboxylase, a fatty acid biosynthetic enzyme whose inhibition attenuates viral replication
    Cody M Spencer
    Department of Biochemistry and Biophysics, University of Rochester Medical Center, 601 Elmwood Ave, Box 712, Rochester, NY 14642, USA
    J Virol 85:5814-24. 2011
  9. pmc The human cytomegalovirus protein TRS1 inhibits autophagy via its interaction with Beclin 1
    Magali Chaumorcel
    INSERM UMR984, Universite Paris Sud, Faculte de Pharmacie, Chatenay Malabry, France
    J Virol 86:2571-84. 2012
  10. pmc NKG2D ligand MICA is retained in the cis-Golgi apparatus by human cytomegalovirus protein UL142
    Omodele Ashiru
    Department of Pathology, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom
    J Virol 83:12345-54. 2009

Detail Information

Publications355 found, 100 shown here

  1. ncbi Host immune system gene targeting by a viral miRNA
    Noam Stern-Ginossar
    Lautenberg Center for General and Tumor Immunology, Hebrew University Hadassah Medical School, Jerusalem, Israel
    Science 317:376-81. 2007
    ..We developed an algorithm for the prediction of miRNA targets and applied it to human cytomegalovirus miRNAs, resulting in the identification of the major histocompatibility complex class I-related chain B (MICB)..
  2. pmc Seropositivity to cytomegalovirus, inflammation, all-cause and cardiovascular disease-related mortality in the United States
    Amanda M Simanek
    Department of Epidemiology, Center for Social Epidemiology and Population Health, School of Public Health, University of Michigan, Ann Arbor, Michigan, United States of America
    PLoS ONE 6:e16103. 2011
    ..We utilized a U.S. nationally representative study to examine whether CMV infection is associated with all-cause and CVD-related mortality. We also assessed whether CRP level mediated or modified these relationships...
  3. pmc Experimental human cytomegalovirus latency in CD14+ monocytes
    Danna Hargett
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544 1014, USA
    Proc Natl Acad Sci U S A 107:20039-44. 2010
    CD14(+) monocytes are a reservoir for latent human cytomegalovirus, and virus replication is reactivated during their differentiation to macrophages or dendritic cells...
  4. ncbi Human cytomegalovirus directly induces the antiviral protein viperin to enhance infectivity
    Jun Young Seo
    Department of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine, 300 Cedar Street, New Haven, CT 06520 8011, USA
    Science 332:1093-7. 2011
    Viperin is an interferon-inducible protein that is directly induced in cells by human cytomegalovirus (HCMV) infection. Why HCMV would induce viperin, which has antiviral activity, is unknown...
  5. pmc Dynamics of the cellular metabolome during human cytomegalovirus infection
    Joshua Munger
    Department of Molecular Biology, Princeton University, Princeton, New Jersey, United States of America
    PLoS Pathog 2:e132. 2006
    ..spectrometry to measure the levels of 63 different intracellular metabolites at multiple times after human cytomegalovirus (HCMV) infection of human fibroblasts...
  6. pmc Human cytomegalovirus activates inflammatory cytokine responses via CD14 and Toll-like receptor 2
    Teresa Compton
    McArdle Laboratory for Cancer Research, University of Wisconsin Madison Medical School, Madison, Wisconsin 53706, USA
    J Virol 77:4588-96. 2003
    Human cytomegalovirus (CMV) is a ubiquitous opportunistic pathogen that causes significant morbidity and mortality in immunocompromised people...
  7. pmc Human CD4+ CD25+ regulatory T cells control T-cell responses to human immunodeficiency virus and cytomegalovirus antigens
    Einar M Aandahl
    Gladstone Institute of Virology and Immunology, University of California San Francisco, San Francisco, California 94110, USA
    J Virol 78:2454-9. 2004
    ..Depletion of T(R) cells from peripheral blood mononuclear cells enhances T-cell responses to cytomegalovirus and human immunodeficiency virus antigens...
  8. pmc Human cytomegalovirus induces the activity and expression of acetyl-coenzyme A carboxylase, a fatty acid biosynthetic enzyme whose inhibition attenuates viral replication
    Cody M Spencer
    Department of Biochemistry and Biophysics, University of Rochester Medical Center, 601 Elmwood Ave, Box 712, Rochester, NY 14642, USA
    J Virol 85:5814-24. 2011
    We have previously reported that human cytomegalovirus (HCMV) infection induces large-scale changes to host cell glycolytic, nucleic acid, and phospholipid metabolism...
  9. pmc The human cytomegalovirus protein TRS1 inhibits autophagy via its interaction with Beclin 1
    Magali Chaumorcel
    INSERM UMR984, Universite Paris Sud, Faculte de Pharmacie, Chatenay Malabry, France
    J Virol 86:2571-84. 2012
    Human cytomegalovirus modulates macroautophagy in two opposite directions. First, HCMV stimulates autophagy during the early stages of infection, as evident by an increase in the number of autophagosomes and a rise in the autophagic flux...
  10. pmc NKG2D ligand MICA is retained in the cis-Golgi apparatus by human cytomegalovirus protein UL142
    Omodele Ashiru
    Department of Pathology, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom
    J Virol 83:12345-54. 2009
    Human cytomegalovirus (HCMV) evades T-cell recognition by down-regulating expression of major histocompatibility complex (MHC) class I and II molecules on the surfaces of infected cells...
  11. ncbi Review of cytomegalovirus seroprevalence and demographic characteristics associated with infection
    Michael J Cannon
    National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention CDC, Atlanta, GA 30329, USA
    Rev Med Virol 20:202-13. 2010
    b>Cytomegalovirus establishes a lifelong latent infection following primary infection that can periodically reactivate with shedding of infectious virus...
  12. pmc Detection of human cytomegalovirus in medulloblastomas reveals a potential therapeutic target
    Ninib Baryawno
    Karolinska Institutet, Department of Women s and Children s Health, Childhood Cancer Research Unit, Stockholm, Sweden
    J Clin Invest 121:4043-55. 2011
    ..They express high levels of COX-2 and produce PGE2, which stimulates tumor cell proliferation. Human cytomegalovirus (HCMV) is prevalent in the human population and encodes proteins that provide immune evasion strategies and ..
  13. ncbi Genetic content of wild-type human cytomegalovirus
    Aidan Dolan
    MRC Virology Unit, Institute of Virology, Church Street, Glasgow G11 5JR, UK
    J Gen Virol 85:1301-12. 2004
    The genetic content of wild-type human cytomegalovirus was investigated by sequencing the 235 645 bp genome of a low passage strain (Merlin)...
  14. pmc Investigation of CMV disease in immunocompromised patients
    V C Emery
    Department of Virology, Royal Free and University College Medical School, Royal Free Campus, Rowland Hill Street, London NW3 2PF, UK
    J Clin Pathol 54:84-8. 2001
    b>Cytomegalovirus (CMV) is a recognised cause of morbidity and mortality in immunocompromised individuals...
  15. ncbi Platelet-derived growth factor-alpha receptor activation is required for human cytomegalovirus infection
    Liliana Soroceanu
    Department of Neurosciences, California Pacific Medical Center Research Institute, Suite 220, 475 Brannan Street, San Francisco, California 94107, USA
    Nature 455:391-5. 2008
    Human cytomegalovirus (HCMV) is a ubiquitous human herpesvirus that can cause life-threatening disease in the fetus and the immunocompromised host...
  16. pmc Systems-level metabolic flux profiling identifies fatty acid synthesis as a target for antiviral therapy
    Joshua Munger
    Department of Molecular Biology, Lewis Thomas Laboratory, Princeton University, Princeton, New Jersey 08544, USA
    Nat Biotechnol 26:1179-86. 2008
    ..on liquid chromatography-tandem mass spectrometry to quantify changes in metabolic activity induced by human cytomegalovirus (HCMV)...
  17. ncbi Review and meta-analysis of the epidemiology of congenital cytomegalovirus (CMV) infection
    Aileen Kenneson
    National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Rev Med Virol 17:253-76. 2007
    We reviewed studies that reported results of systematic cytomegalovirus (CMV) screening on fetuses and/or live-born infants. The overall birth prevalence of congenital CMV infection was 0...
  18. pmc Human cytomegalovirus UL131-128 genes are indispensable for virus growth in endothelial cells and virus transfer to leukocytes
    Gabriele Hahn
    Max von Pettenkofer Institut, Abteilung Virologie, Ludwig Maximilians Universitat Munchen, Munich, Germany
    J Virol 78:10023-33. 2004
    Human cytomegalovirus (HCMV), a ubiquitous human pathogen, is the leading cause of birth defects and morbidity in immunocompromised patients and a potential trigger for vascular disease...
  19. pmc Molecular profiling of cytomegalovirus-induced human CD8+ T cell differentiation
    Kirsten M L Hertoghs
    Department of Experimental Immunology, Academic Medical Center, Amsterdam, The Netherlands
    J Clin Invest 120:4077-90. 2010
    CD8+ T cells play a critical role in the immune response to viral pathogens. Persistent human cytomegalovirus (HCMV) infection results in a strong increase in the number of virus-specific, quiescent effector-type CD8+ T cells with ..
  20. ncbi Adoptive transfer and selective reconstitution of streptamer-selected cytomegalovirus-specific CD8+ T cells leads to virus clearance in patients after allogeneic peripheral blood stem cell transplantation
    Anita Schmitt
    Department of Internal Medicine III, The Institute For Transfusion Medicine, and the Institute for Virology, University of Ulm, Ulm, Germany
    Transfusion 51:591-9. 2011
    b>Cytomegalovirus (CMV) disease constitutes a serious complication after allogeneic stem cell transplantation. For the clearance of CMV, CD8+ T cells are pivotal.
  21. pmc Reconstruction of the complete human cytomegalovirus genome in a BAC reveals RL13 to be a potent inhibitor of replication
    Richard J Stanton
    Section of Medical Microbiology, Department of Infection, Immunity and Biochemistry, School of Medicine, Cardiff University, Cardiff, UK
    J Clin Invest 120:3191-208. 2010
    Human cytomegalovirus (HCMV) in clinical material cannot replicate efficiently in vitro until it has adapted by mutation. Consequently, wild-type HCMV differ fundamentally from the passaged strains used for research...
  22. pmc Divergent effects of human cytomegalovirus and herpes simplex virus-1 on cellular metabolism
    Livia Vastag
    Department of Chemistry, Princeton University, Princeton, New Jersey, United States of America
    PLoS Pathog 7:e1002124. 2011
    ..Here we used mass spectrometry to examine the impact of two related herpesviruses, human cytomegalovirus (HCMV) and herpes simplex virus type-1 (HSV-1), on the metabolism of fibroblast and epithelial host cells...
  23. ncbi Human cytomegalovirus immunity and immune evasion
    Sarah E Jackson
    Department of Medicine, University of Cambridge, Level 5, Addenbrookes Hospital, Hills Rd, Cambridge CB2 0QQ, UK
    Virus Res 157:151-60. 2011
    Human cytomegalovirus (HCMV) infection induces both innate immune responses including Natural Killer cells as well as adaptive humoral and cell mediated (CD4+ helper, CD8+ cytotoxic and γδ T cell) responses which lead to the resolution ..
  24. pmc Cytomegalovirus reactivation after allogeneic transplantation promotes a lasting increase in educated NKG2C+ natural killer cells with potent function
    Bree Foley
    Department of Hematology, Oncology, and Transplantation, University of Minnesota, Minneapolis, MN 55455, USA
    Blood 119:2665-74. 2012
    During mouse cytomegalovirus (CMV) infection, a population of Ly49H(+) natural killer (NK) cells expands and is responsible for disease clearance through the induction of a "memory NK-cell response...
  25. pmc Human cytomegalovirus induces the interferon response via the DNA sensor ZBP1
    Victor R DeFilippis
    Oregon Health and Science University, Vaccine and Gene Therapy Institute, Beaverton, OR 97006, USA
    J Virol 84:585-98. 2010
    Human cytomegalovirus (HCMV) is a member of the betaherpesvirus family that, unlike other herpesviruses, triggers a strong innate immune response in infected cells that includes transcription of the beta interferon gene via activation of ..
  26. ncbi HCMV microinfections in inflammatory diseases and cancer
    Cecilia Soderberg-Naucler
    Karolinska Insititutet, Center for Molecular Medicine, L8 03, Department of Medicine, Karolinska Hospital, SE 171 76 Stockholm, Sweden
    J Clin Virol 41:218-23. 2008
    Human cytomegalovirus (HCMV) is a wide-spread human virus that was mainly known to cause disease in immunocompromised patients...
  27. pmc Viperin (cig5), an IFN-inducible antiviral protein directly induced by human cytomegalovirus
    K C Chin
    Section of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine, 310 Cedar Street, New Haven, CT 06520 8011, USA
    Proc Natl Acad Sci U S A 98:15125-30. 2001
    Little is known about the mechanism by which IFNs inhibit human cytomegalovirus (HCMV) replication...
  28. pmc Identification of proteins in human cytomegalovirus (HCMV) particles: the HCMV proteome
    Susan M Varnum
    Department of Molecular Microbiology and Immunology, Oregon Health Sciences University, Portland, OR 97201, USA
    J Virol 78:10960-6. 2004
    Human cytomegalovirus (HCMV), a member of the herpesvirus family, is a large complex enveloped virus composed of both viral and cellular gene products...
  29. pmc Human cytomegalovirus infection alters the expression of cellular microRNA species that affect its replication
    Fu Zhang Wang
    Department of Molecular Genetics, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Virol 82:9065-74. 2008
    ..Many cellular processes are altered through a variety of mechanisms by human cytomegalovirus (HCMV) infection...
  30. pmc Coding potential of laboratory and clinical strains of human cytomegalovirus
    Eain Murphy
    Department of Molecular Biology, Princeton University, Princeton, NJ 80544, USA
    Proc Natl Acad Sci U S A 100:14976-81. 2003
    Six strains of human cytomegalovirus have been sequenced, including two laboratory strains (AD169 and Towne) that have been extensively passaged in fibroblasts and four clinical isolates that have been passaged to a limited extent in the ..
  31. ncbi Epidermal growth factor receptor is a cellular receptor for human cytomegalovirus
    Xin Wang
    Lineberger Comprehensive Cancer Center, Department of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7295, USA
    Nature 424:456-61. 2003
    Human cytomegalovirus (HCMV) is a widespread opportunistic herpesvirus that causes severe and fatal diseases in immune-compromised individuals, including organ transplant recipients and individuals with AIDS...
  32. pmc Evasion of CD8+ T cells is critical for superinfection by cytomegalovirus
    Scott G Hansen
    Vaccine and Gene Therapy Institute, Oregon Health and Science University, 505 Northwest 185th Avenue, Beaverton, OR 97006, USA
    Science 328:102-6. 2010
    b>Cytomegalovirus (CMV) can superinfect persistently infected hosts despite CMV-specific humoral and cellular immunity; however, how it does so remains undefined...
  33. pmc Human cytomegalovirus infection activates and regulates the unfolded protein response
    Jennifer A Isler
    Department of Cancer Biology, Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, USA
    J Virol 79:6890-9. 2005
    ..We demonstrate that human cytomegalovirus (HCMV) infection induces the UPR but specifically regulates the three branches of UPR signaling, PKR-like ER ..
  34. ncbi Cell-dependent interference of a series of new 6-aminoquinolone derivatives with viral (HIV/CMV) transactivation
    Miguel Stevens
    Rega Institute for Medical Research, Katholieke Universiteit Leuven, B 3000 Leuven, Belgium
    J Antimicrob Chemother 56:847-55. 2005
    ..These potent 6-aminoquinolones were further evaluated for their broad-spectrum antiviral properties...
  35. pmc Is HCMV a tumor promoter?
    Liliana Soroceanu
    California Pacific Medical Center Research Institute, 475 Brannan Street, Suite 220, San Francisco, CA 94107, USA liliana
    Virus Res 157:193-203. 2011
    Human cytomegalovirus (HCMV) is a beta-herpesvirus that causes persistent infection in humans and can cause severe disease in fetuses and immunocompromised individuals...
  36. ncbi Cytomegalovirus cell tropism
    C Sinzger
    Institute of Medical Virology, University of Tubingen, Elfriede Aulhorn Str 6, 72076 Tubingen, Germany
    Curr Top Microbiol Immunol 325:63-83. 2008
    The human cytomegalovirus (HCMV) can infect a remarkably broad cell range within its host, including parenchymal cells and connective tissue cells of virtually any organ and various hematopoietic cell types...
  37. pmc Human cytomegalovirus protein pp71 displaces the chromatin-associated factor ATRX from nuclear domain 10 at early stages of infection
    Vera Lukashchuk
    Medical Research Council Virology Unit, Church Street, Glasgow G11 5JR, Scotland, United Kingdom
    J Virol 82:12543-54. 2008
    The human cytomegalovirus (HCMV) tegument protein pp71, encoded by gene UL82, stimulates viral immediate-early (IE) transcription...
  38. pmc Temporal dynamics of cytomegalovirus chromatin assembly in productively infected human cells
    Alexandra Nitzsche
    Institute for Medical Microbiology and Hygiene, University of Regensburg, Franz Josef Strauss Allee 11, 93053 Regensburg, Germany
    J Virol 82:11167-80. 2008
    The genomes of herpesviruses, including human cytomegalovirus (CMV), are double-stranded DNA molecules maintained as episomes during infection. The viral DNA lacks histones when encapsidated in the virion...
  39. pmc Evidence for a role of the cellular ND10 protein PML in mediating intrinsic immunity against human cytomegalovirus infections
    Nina Tavalai
    Institut für Klinische und Molekulare Virologie der Universität Erlangen Nürnberg, Schlossgarten 4, 91054 Erlangen, Germany
    J Virol 80:8006-18. 2006
    Several viruses, including human cytomegalovirus (HCMV), encode proteins that colocalize with a cellular subnuclear structure known as ND10...
  40. pmc Integrin alphavbeta3 is a coreceptor for human cytomegalovirus
    Xin Wang
    Lineberger Comprehensive Cancer Center, CB 7295, Lineberger Building, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Nat Med 11:515-21. 2005
    Human cytomegalovirus (HCMV) is a widespread opportunistic pathogen that causes birth defects in newborns and severe disease in immunocompromised individuals. The broad tropism of HCMV infection suggests that it uses multiple receptors...
  41. ncbi Seroprevalence of cytomegalovirus infection in the United States, 1988-1994
    Stephanie A S Staras
    Department of Epidemiology, Emory University, Atlanta, GA 30322, USA
    Clin Infect Dis 43:1143-51. 2006
    b>Cytomegalovirus (CMV) is a leading cause of congenital illness and disability, including hearing loss and mental retardation...
  42. ncbi The human cytomegalovirus-encoded chemokine receptor US28 promotes angiogenesis and tumor formation via cyclooxygenase-2
    David Maussang
    Leiden Amsterdam Center for Drug Research, Division of Medicinal Chemistry, Faculty of Sciences, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
    Cancer Res 69:2861-9. 2009
    The human cytomegalovirus (HCMV), potentially associated with the development of malignancies, encodes the constitutively active chemokine receptor US28...
  43. ncbi Modulation of HLA expression in human cytomegalovirus immune evasion
    Aifen Lin
    Medical Research Center, Wenzhou Medical College Affiliated Taizhou Hospital of Zhejiang Province, Linhai, Zhejiang 317000, China
    Cell Mol Immunol 4:91-8. 2007
    Human cytomegalovirus (hCMV) has evolved multiple mechanisms to escape the host immune recognition and innate or adaptive immune responses...
  44. pmc High-resolution human cytomegalovirus transcriptome
    Derek Gatherer
    Medical Research Council University of Glasgow Centre for Virus Research, Glasgow G11 5JR, United Kingdom
    Proc Natl Acad Sci U S A 108:19755-60. 2011
    Deep sequencing was used to bring high resolution to the human cytomegalovirus (HCMV) transcriptome at the stage when infectious virion production is under way, and major findings were confirmed by extensive experimentation using ..
  45. ncbi A protein kinase CK2 site flanking the nuclear targeting signal enhances nuclear transport of human cytomegalovirus ppUL44
    Gualtiero Alvisi
    Dipartimento di Medicina Clinica Specialistica e Sperimentale, Sezione di Microbiologia, Universita degli Studi di Bologna, Bologna, Italy
    Traffic 6:1002-13. 2005
    The processivity factor of the human cytomegalovirus (HCMV) DNA polymerase phosphoprotein ppUL44 plays an essential role in viral replication, showing nuclear localization in infected cells...
  46. ncbi Dendritic-cell infection by human cytomegalovirus is restricted to strains carrying functional UL131-128 genes and mediates efficient viral antigen presentation to CD8+ T cells
    Giuseppe Gerna
    Servizio di Virologia, IRCCS Policlinico San Matteo, 27100 Pavia, Italy
    J Gen Virol 86:275-84. 2005
    Human cytomegalovirus (HCMV) genetic determinants of endothelial-cell tropism and virus transfer to leukocytes (both polymorphonuclear and monocyte) have been recently identified in the UL131-128 genes...
  47. pmc Synaptic vesicle-like lipidome of human cytomegalovirus virions reveals a role for SNARE machinery in virion egress
    Sean T H Liu
    Department of Molecular Biology, Lewis Thomas Laboratory, University, Princeton, NJ 08544, USA
    Proc Natl Acad Sci U S A 108:12869-74. 2011
    Human cytomegalovirus induces and requires fatty acid synthesis. This suggests an essential role for lipidome remodeling in viral replication...
  48. ncbi Investigation of promoter variations in dendritic cell-specific ICAM3-grabbing non-integrin (DC-SIGN) (CD209) and their relevance for human cytomegalovirus reactivation and disease after allogeneic stem-cell transplantation
    M Mezger
    Julius Maximilians Universitat Wurzburg, Medizinische Klinik II, Wurzburg, Germany
    Clin Microbiol Infect 14:228-34. 2008
    ..pathogen recognition and virus entry receptors (n = 7) were screened to detect any association with human cytomegalovirus (hCMV) reactivation and disease in patients following allogeneic stem-cell transplantation...
  49. ncbi Signature microRNA expression profile of essential hypertension and its novel link to human cytomegalovirus infection
    Shuqiang Li
    Department of Cardiology, Chaoyang Hospital, Capital Medical University, Beijing 100020, China
    Circulation 124:175-84. 2011
    ..Recent studies demonstrated that microRNAs (miRNAs) are involved in cardiac hypertrophy and heart failure. However, little is known about the roles of miRNAs in essential hypertension...
  50. pmc Human cytomegalovirus microRNA miR-US4-1 inhibits CD8(+) T cell responses by targeting the aminopeptidase ERAP1
    Sungchul Kim
    National Creative Research Initiative Center for Antigen Presentation, Department of Biological Sciences, Seoul National University, Seoul, Republic of Korea
    Nat Immunol 12:984-91. 2011
    ..The US2-US11 genomic region of human cytomegalovirus (HCMV) is dispensable for viral replication and encodes three microRNAs (miRNAs)...
  51. pmc Protein pUL128 of human cytomegalovirus is necessary for monocyte infection and blocking of migration
    Sarah Straschewski
    Institute of Virology, Ulm University Hospital, Albert Einstein Allee 11, 89081 Ulm, Germany
    J Virol 85:5150-8. 2011
    We have previously shown that only endotheliotropic strains of human cytomegalovirus (HCMV), such as TB40E, infect monocytes and impair their chemokine-driven migration...
  52. ncbi Human cytomegalovirus and mucoepidermoid carcinoma of salivary glands: cell-specific localization of active viral and oncogenic signaling proteins is confirmatory of a causal relationship
    Michael Melnick
    Laboratory for Developmental Genetics, USC, Los Angeles, CA 90089 0641, USA
    Exp Mol Pathol 92:118-25. 2012
    Human cytomegalovirus (hCMV) infection is common. Although still controversial, there is growing evidence that active hCMV infection is associated with a variety of malignancies, including brain, breast, lung, colon, and prostate...
  53. ncbi The human cytomegalovirus genome revisited: comparison with the chimpanzee cytomegalovirus genome
    Andrew J Davison
    MRC Virology Unit, Institute of Virology, Church Street, Glasgow G11 5JR, UK
    J Gen Virol 84:17-28. 2003
    The gene complement of wild-type human cytomegalovirus (HCMV) is incompletely understood, on account of the size and complexity of the viral genome and because laboratory strains have undergone deletions and rearrangements during ..
  54. pmc Immunobiology of human cytomegalovirus: from bench to bedside
    Tania Crough
    Division of Immunology, Tumour Immunology Laboratory, Australian Centre for Vaccine Development, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Clin Microbiol Rev 22:76-98, Table of Contents. 2009
    Following primary infection, human cytomegalovirus (HCMV) establishes lifelong latency and periodically reactivates without causing symptoms in healthy individuals...
  55. pmc Human cytomegalovirus glycoprotein B is required for virus entry and cell-to-cell spread but not for virion attachment, assembly, or egress
    Marisa K Isaacson
    McArdle Laboratory for Cancer Research, University of Wisconsin Madison Medical School, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    J Virol 83:3891-903. 2009
    ..Human cytomegalovirus (HCMV) gB (UL55) plays an essential role in the replication cycle of the virus...
  56. ncbi Epstein-Barr virus and cytomegalovirus in autoimmune diseases: are they truly notorious? A preliminary report
    O Barzilai
    Center for Autoimmune Diseases, Department of Medicine B, Sheba Medical Center, Tel Hashomer, Israel
    Ann N Y Acad Sci 1108:567-77. 2007
    ..Epstein-Barr virus (EBV) and cytomegalovirus (CMV) are considered to be notorious as they are consistently associated with multiple autoimmune diseases...
  57. pmc The m74 gene product of murine cytomegalovirus (MCMV) is a functional homolog of human CMV gO and determines the entry pathway of MCMV
    Laura Scrivano
    Max von Pettenkofer Institut, Lehrstuhl Virologie, Feodor Lynen Strasse 25, D 81377 Munich, Germany
    J Virol 84:4469-80. 2010
    The glycoprotein gO (UL74) of human cytomegalovirus (HCMV) forms a complex with gH/gL...
  58. pmc Nuclear domain 10 components promyelocytic leukemia protein and hDaxx independently contribute to an intrinsic antiviral defense against human cytomegalovirus infection
    Nina Tavalai
    Institut fur Klinische und Molekulare Virologie, University Hospital Erlangen, Schlossgarten 4, 91054 Erlangen, Germany
    J Virol 82:126-37. 2008
    ..like hDaxx or promyelocytic leukemia protein (PML), mediate an intrinsic immune response against human cytomegalovirus (HCMV) infection, strengthening the assumption that ND10 components are part of a cellular antiviral defense ..
  59. pmc Vaccine prevention of maternal cytomegalovirus infection
    Robert F Pass
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham 35233, USA
    N Engl J Med 360:1191-9. 2009
    Congenital infection with cytomegalovirus (CMV) is an important cause of hearing, cognitive, and motor impairments in newborns.
  60. ncbi Structural basis for translational stalling by human cytomegalovirus and fungal arginine attenuator peptide
    Shashi Bhushan
    Gene Center and Department of Biochemistry and Center for integrated Protein Science Munich, University of Munich, Feodor Lynen Strasse 25, 81377 Munich, Germany
    Mol Cell 40:138-46. 2010
    ..translation of two diverse regulatory peptides: the fungal arginine attenuator peptide (AAP) and the human cytomegalovirus (hCMV) gp48 upstream open reading frame 2 (uORF2)...
  61. pmc Inactivating a cellular intrinsic immune defense mediated by Daxx is the mechanism through which the human cytomegalovirus pp71 protein stimulates viral immediate-early gene expression
    Ryan T Saffert
    Institute for Molecular Virology, and McArdle Laboratory for Cancer Research, University of Wisconsin Madison, 1525 Linden Drive, Madison, Wisconsin 53706, USA
    J Virol 80:3863-71. 2006
    Human cytomegalovirus (HCMV) masterfully evades adaptive and innate immune responses, allowing infection to be maintained and periodically reactivated for the life of the host...
  62. ncbi A novel immunoglobulin superfamily receptor for cellular and viral MHC class I molecules
    D Cosman
    Immunex Corporation, Seattle, Washington 98101, USA
    Immunity 7:273-82. 1997
    The human cytomegalovirus UL18 gene product is a homolog of cellular major histocompatibility (MHC) class I antigens...
  63. pmc Transgene expression is associated with copy number and cytomegalovirus promoter methylation in transgenic pigs
    Qingran Kong
    College of Life Science, Northeast Agricultural University of China, Harbin, People s Republic of China
    PLoS ONE 4:e6679. 2009
    ..pigs by somatic cell nuclear transfer (SCNT) that express green fluorescent protein (GFP) driven by cytomegalovirus (CMV)...
  64. pmc Cytomegalovirus antibody levels, inflammation, and mortality among elderly Latinos over 9 years of follow-up
    Eric T Roberts
    Department of Epidemiology, 3659 SPH Tower, 109 Observatory, Ann Arbor, MI 48104 2548, USA
    Am J Epidemiol 172:363-71. 2010
    This study examined the relation between immune response to cytomegalovirus (CMV) and all-cause and cardiovascular disease (CVD) mortality, and possible mediating mechanisms...
  65. pmc A human cytomegalovirus gO-null mutant fails to incorporate gH/gL into the virion envelope and is unable to enter fibroblasts and epithelial and endothelial cells
    Paul T Wille
    Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Virol 84:2585-96. 2010
    Human cytomegalovirus (HCMV) depends upon a five-protein complex, gH/gL/UL128-131, to enter epithelial and endothelial cells. A separate HCMV gH/gL-containing complex, gH/gL/gO, has been described...
  66. ncbi Human Daxx-mediated repression of human cytomegalovirus gene expression correlates with a repressive chromatin structure around the major immediate early promoter
    David L Woodhall
    Department of Medicine, University of Cambridge, Cambridge CB2 2QQ, United Kingdom
    J Biol Chem 281:37652-60. 2006
    ..knockdown of human Daxx (hDaxx) expression, an important component of ND10, prior to infection with human cytomegalovirus resulted in increased levels of viral immediate early RNA and protein expression and that this correlated ..
  67. pmc Alpha-(1-3)- and alpha-(1-6)-D-mannose-specific plant lectins are markedly inhibitory to human immunodeficiency virus and cytomegalovirus infections in vitro
    J Balzarini
    Laboratory of Chemotherapy, Rega Institute for Medical Research, Katholieke Universiteit Leuven, Belgium
    Antimicrob Agents Chemother 35:410-6. 1991
    ..however, the plant lectins did not inhibit the replication of other enveloped viruses, except for human cytomegalovirus (50% effective concentration, 0.9 to 1.6 microgram/ml)...
  68. ncbi Expansions of peripheral blood CD8 T-lymphocyte subpopulations and an association with cytomegalovirus seropositivity in the elderly: the Swedish NONA immune study
    Anders Wikby
    Department of Natural Science and Biomedicine, University College of Health Sciences, Jonkoping, Sweden
    Exp Gerontol 37:445-53. 2002
    ..was significantly associated with a CD4/CD8 ratio less than one and positive IgG serologic titers to cytomegalovirus (CMV)...
  69. ncbi Cytomegalovirus-specific CD4+ T cells in healthy carriers are continuously driven to replicative exhaustion
    Jean M Fletcher
    Department of Immunology and Molecular Pathology, Division of Infection and Immunity, University College London, London, United Kingdom
    J Immunol 175:8218-25. 2005
    ....
  70. pmc Latency, chromatin remodeling, and reactivation of human cytomegalovirus in the dendritic cells of healthy carriers
    M B Reeves
    Department of Medicine, School of Clinical Medicine, University of Cambridge, Hills Road, Cambridge CB2 2QQ, United Kingdom
    Proc Natl Acad Sci U S A 102:4140-5. 2005
    Human cytomegalovirus (HCMV) persists as a subclinical, lifelong infection in the normal human host, but reactivation from latency in immunocompromised subjects results in serious disease...
  71. pmc HCMV gH/gL/UL128-131 interferes with virus entry into epithelial cells: evidence for cell type-specific receptors
    Brent J Ryckman
    Department of Molecular Microbiology and Immunology, Oregon Health and Sciences University, Portland, OR 97239, USA
    Proc Natl Acad Sci U S A 105:14118-23. 2008
    Human cytomegalovirus (HCMV) forms two different membrane protein complexes, gH/gL/gO and gH/gL/UL128/UL130/UL131, that function in different cell types...
  72. ncbi Lytic infection of permissive cells with human cytomegalovirus is regulated by an intrinsic 'pre-immediate-early' repression of viral gene expression mediated by histone post-translational modification
    Ian J Groves
    Department of Medicine, University of Cambridge, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2QQ, UK
    J Gen Virol 90:2364-74. 2009
    Human cytomegalovirus (HCMV) lytic gene expression occurs in a regulated cascade, initiated by expression of the viral major immediate-early (IE) proteins...
  73. ncbi Inhibition of the NKp30 activating receptor by pp65 of human cytomegalovirus
    Tal I Arnon
    The Lautenberg Center for General and Tumor Immunology, The Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
    Nat Immunol 6:515-23. 2005
    Human cytomegalovirus, a chief pathogen in immunocompromised people, can persist in a healthy immunocompetent host throughout life without being eliminated by the immune system...
  74. ncbi Specific localisation of human cytomegalovirus nucleic acids and proteins in human colorectal cancer
    Lualhati Harkins
    Pathology Service, Birmingham Veterans Affairs Hospital, Birmingham, AL, USA
    Lancet 360:1557-63. 2002
    ..Human cytomegalovirus is a beta-herpesvirus that is endemic in the human population and can cause life-threatening disease in ..
  75. ncbi Role of the cellular protein hDaxx in human cytomegalovirus immediate-early gene expression
    Chris M Preston
    Medical Research Council Virology Unit, Glasgow, UK
    J Gen Virol 87:1113-21. 2006
    Human cytomegalovirus (HCMV) immediate-early (IE) transcription is stimulated by virion phosphoprotein pp71, the product of gene UL82...
  76. pmc Potent immunosuppressive activities of cytomegalovirus-encoded interleukin-10
    Juliet V Spencer
    ChemoCentryx, San Carlos, California 94070, USA
    J Virol 76:1285-92. 2002
    b>Cytomegalovirus (CMV) has highly evolved mechanisms for avoiding detection by the host immune system...
  77. pmc Human cytomegalovirus glycoprotein UL16 causes intracellular sequestration of NKG2D ligands, protecting against natural killer cell cytotoxicity
    Claire Dunn
    Department of Molecular Microbiology and Immunology, Oregon Health and Sciences University, Portland, OR 97239, USA
    J Exp Med 197:1427-39. 2003
    ..The human cytomegalovirus (HCMV) membrane glycoprotein, UL16, binds to three of the five known ligands for human NKG2D...
  78. ncbi Proteasome-dependent, ubiquitin-independent degradation of Daxx by the viral pp71 protein in human cytomegalovirus-infected cells
    Jiwon Hwang
    Institute for Molecular Virology and McArdle Laboratory for Cancer Research, University of Wisconsin Madison, Madison, WI 53706, USA
    Virology 367:334-8. 2007
    The cellular Daxx protein represses human cytomegalovirus (HCMV) gene expression from the major immediate early promoter...
  79. pmc New cembranolides from the Dongsha Atoll soft coral Lobophytum durum
    Shi Yie Cheng
    Department of Marine Biotechnology and Resources, National Sun Yat Sen University, Kaohsiung 804, Taiwan
    Mar Drugs 9:1307-18. 2011
    ..8 μg/mL. Moreover, compound 5 showed significant antiviral activity against human cytomegalovirus with an IC₅₀ of 5.2 μg/mL.
  80. pmc Activation of peroxisome proliferator-activated receptor gamma by human cytomegalovirus for de novo replication impairs migration and invasiveness of cytotrophoblasts from early placentas
    Benjamin Rauwel
    NSERM, U563, Toulouse F 31300, France
    J Virol 84:2946-54. 2010
    Human cytomegalovirus (HCMV) contributes to pathogenic processes in immunosuppressed individuals, in fetuses, and in neonates...
  81. ncbi Phenotypic and functional heterogeneity of human NK cells developing after umbilical cord blood transplantation: a role for human cytomegalovirus?
    Mariella Della Chiesa
    DI ME S Dipartimento di Medicina Sperimentale, Universita di Genova, Italy
    Blood 119:399-410. 2012
    ..In other patients, most NK cells maintained an immature phenotype even after 12 months. A possible role for cytomegalovirus in the promotion of NK-cell development was suggested by the observation that a more rapid NK-cell maturation ..
  82. pmc The human cytomegalovirus UL44 C clamp wraps around DNA
    Gloria Komazin-Meredith
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA
    Structure 16:1214-25. 2008
    ..The human cytomegalovirus DNA polymerase subunit UL44 forms a C clamp-shaped dimer intermediate in structure between monomeric herpes ..
  83. pmc Human cytomegalovirus chemokine receptor gene US28 is transcribed in latently infected THP-1 monocytes
    P S Beisser
    Unite d Immunologie Virale, Institut Pasteur, 75274 Paris Cedex 15, France
    J Virol 75:5949-57. 2001
    The human cytomegalovirus (HCMV) US28 gene product, pUS28, is a G protein-coupled receptor that interacts with both CC and CX(3)C chemokines...
  84. ncbi NKp46 and DNAM-1 NK-cell receptors drive the response to human cytomegalovirus-infected myeloid dendritic cells overcoming viral immune evasion strategies
    Giuliana Magri
    Immunology Unit, Pompeu Fabra University, Barcelona, Spain
    Blood 117:848-56. 2011
    Information on natural killer (NK)-cell receptor-ligand interactions involved in the response to human cytomegalovirus (HCMV) is limited and essentially based on the study of infected fibroblasts...
  85. ncbi Presumed fuchs heterochromic iridocyclitis and Posner-Schlossman syndrome: comparison of cytomegalovirus-positive and negative eyes
    Soon Phaik Chee
    Singapore National Eye Centre, Singapore
    Am J Ophthalmol 146:883-9.e1. 2008
    To compare the characteristics of cytomegalovirus (CMV)-positive and negative eyes with presumed Posner-Schlossman syndrome (PSS) and Fuchs heterochromic iridocyclitis (FHI).
  86. pmc Recombinant antibodies encoded by IGHV1-69 react with pUL32, a phosphoprotein of cytomegalovirus and B-cell superantigen
    Christoph Steininger
    Department of Medicine I, Medical University of Vienna, Austria
    Blood 119:2293-301. 2012
    ..by IGHV1-69 or IGHV3-21, but not a CLL rAb encoded by IGHV4-39 genes, reacted with a single protein of human cytomegalovirus (CMV). The CMV protein was identified as the large structural phosphoprotein pUL32...
  87. pmc Human cytomegalovirus glycoprotein gO complexes with gH/gL, promoting interference with viral entry into human fibroblasts but not entry into epithelial cells
    Adam L Vanarsdall
    L 220, Department of Microbiology and Immunology, Oregon Health and Science University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, USA
    J Virol 85:11638-45. 2011
    A complex of five human cytomegalovirus virus (HCMV) proteins, gH, gL, UL128, UL130, and UL131 (gH/gL/UL128-131), is essential for virus entry into epithelial cells...
  88. pmc Consensus on the role of human cytomegalovirus in glioblastoma
    Kristine Dziurzynski
    Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, 1400 Holcombe Blvd, Unit 442, Houston, TX 77030, USA
    Neuro Oncol 14:246-55. 2012
    The human cytomegalovirus (HCMV) and glioma symposium was convened on April 17, 2011 in Washington, DC, and was attended by oncologists and virologists involved in studying the relationship between HCMV and gliomas...
  89. pmc Broadly targeted human cytomegalovirus-specific CD4+ and CD8+ T cells dominate the memory compartments of exposed subjects
    Andrew W Sylwester
    Vaccine and Gene Therapy Institute, Department of Pathology, Oregon Health and Science University, Beaverton, 97006, USA
    J Exp Med 202:673-85. 2005
    Human cytomegalovirus (HCMV) infections of immunocompetent hosts are characterized by a dynamic, life-long interaction in which host immune responses, particularly of T cells, restrain viral replication and prevent disease but do not ..
  90. ncbi Attribution of congenital cytomegalovirus infection to primary versus non-primary maternal infection
    Chengbin Wang
    Centers for Disease Control and Prevention, Atlanta, GA 30345, USA
    Clin Infect Dis 52:e11-3. 2011
    Congenital cytomegalovirus (CMV) infection is a leading cause of developmental disabilities...
  91. ncbi Longitudinal assessment of cytomegalovirus (CMV)-specific immune responses in liver transplant recipients at high risk for late CMV disease
    Corinna La Rosa
    Laboratory of Vaccine Research, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA
    J Infect Dis 195:633-44. 2007
    b>Cytomegalovirus (CMV)-seronegative recipients (R(-)) of a liver transplant from CMV-positive donors (D(+)) are at high risk for developing late CMV disease after discontinuation of antiviral prophylaxis...
  92. pmc All is fair in virus-host interactions: NK cells and cytomegalovirus
    Marina Babic
    Department of Histology and Embryology, Faculty of Medicine, University of Rijeka, B Branchetta 20, 51 000 Rijeka, Croatia
    Trends Mol Med 17:677-85. 2011
    The infection of mice with mouse cytomegalovirus (MCMV) as a model of human cytomegalovirus (HCMV) infection has been particularly informative in elucidating the role of innate and adaptive immune response mechanisms during infection...
  93. pmc Human cytomegalovirus US28 found in glioblastoma promotes an invasive and angiogenic phenotype
    Liliana Soroceanu
    California Pacific Medical Center Research Institute, University of California, San Francisco, California, USA
    Cancer Res 71:6643-53. 2011
    Human cytomegalovirus (HCMV) infections are seen often in glioblastoma multiforme (GBM) tumors, but whether the virus contributes to GBM pathogenesis is unclear...
  94. pmc The carboxy-terminal tail of human cytomegalovirus (HCMV) US28 regulates both chemokine-independent and chemokine-dependent signaling in HCMV-infected cells
    Melissa P Stropes
    Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0524, USA
    J Virol 83:10016-27. 2009
    The human cytomegalovirus (HCMV)-encoded G-protein-coupled receptor (GPCR) US28 is a potent activator of a number of signaling pathways in HCMV-infected cells...
  95. pmc Human cytomegalovirus infection induces adipocyte-like lipogenesis through activation of sterol regulatory element binding protein 1
    Yongjun Yu
    Department of Cancer Biology, Abramson Family Cancer Research Institute, University of Pennsylvania, School of Medicine, Philadelphia, Pennsylvania, USA
    J Virol 86:2942-9. 2012
    ..Human cytomegalovirus (HCMV) infection has been shown to require the induction of lipogenesis...
  96. ncbi Functional killer Ig-like receptors on human memory CD4+ T cells specific for cytomegalovirus
    Jeroen van Bergen
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, The Netherlands
    J Immunol 182:4175-82. 2009
    ..Thus, the CMV-induced down-regulation of HLA class I may in fact enhance memory CMV-specific CD4(+) T cell responses restricted by HLA class II...
  97. ncbi Natural killer cells, viruses and cancer
    A Cerwenka
    Department of Microbiology and Immunology and the Cancer Research Institute, University of California, San Francisco, 94143-0414, USA
    Nat Rev Immunol 1:41-9. 2001
    ..Here, we review the emerging evidence that natural killer cells have an important role in vivo in immune defence...
  98. pmc Cytomegalovirus reactivation in critically ill immunocompetent patients
    Ajit P Limaye
    Department of Laboratory Medicine, University of Washington Medical Center, 1959 NE Pacific St, Seattle, WA 98195 7110, USA
    JAMA 300:413-22. 2008
    b>Cytomegalovirus (CMV) infection is associated with adverse clinical outcomes in immunosuppressed persons, but the incidence and association of CMV reactivation with adverse outcomes in critically ill persons lacking evidence of ..
  99. ncbi Aspects of human cytomegalovirus latency and reactivation
    M Reeves
    Infectious Diseases, Novartis Institutes for BioMedical Research, Cambridge, MA 02139, USA
    Curr Top Microbiol Immunol 325:297-313. 2008
    Primary infection of healthy individuals with human cytomegalovirus (HCMV) is usually asymptomatic and results in the establishment of a lifelong latent infection of the host...
  100. ncbi Receptors and immune sensors: the complex entry path of human cytomegalovirus
    Teresa Compton
    McArdle Laboratory for Cancer Research, 1400 University Avenue, Madison, WI 53706, USA
    Trends Cell Biol 14:5-8. 2004
    The ability of human cytomegalovirus (HCMV) to infect an extensive range of cell types has complicated efforts to identify cellular receptors for this significant pathogen...
  101. ncbi Cytomegalovirus and human immunosenescence
    Graham Pawelec
    Center for Medical Research, University of Tubingen Medical School, Tubingen, Germany
    Rev Med Virol 19:47-56. 2009
    ..Whether the IRP is informative in younger individuals and the mechanism of the CMV effect is discussed in this review...

Research Grants74

  1. Evolution of the Immune Response to Cytomegalovirus Transmitted via Breast Milk
    Lynn Puddington; Fiscal Year: 2010
    ..For example, human cytomegalovirus (HCMV) infection in utero (congenital) can result in growth retardation, microcephaly, sensorineural hearing ..
  2. Human cytomegalovirus entry into epithelial and endothelial cells
    David C Johnson; Fiscal Year: 2013
    Human cytomegalovirus (HCMV) is a ubiquitous, normally benign virus that establishes lifelong persistence and/or latency...
  3. Virus interference with Toll like Receptor Response on Dendritic Cells
    Elina I Zuniga; Fiscal Year: 2010
    ..2008). Remarkably, this TLR dysregulation relates to enhanced susceptibility to both murine cytomegalovirus opportunistic infection and lypopolysaccharide endotoxic shock...
  4. Regulation and Function of the HCMV pp71 Tegument Protein
    Julie Kerry; Fiscal Year: 2009
    Human Cytomegalovirus (HCMV) is a significant human pathogen that causes morbidity and mortality in patients with a compromised immune system, including AIDS patients and recipients of organ and bone marrow transplants...
  5. Herpesvirus protein kinases: Substrate recognition and pathway targeting.
    S Diane Hayward; Fiscal Year: 2013
    ..and Kaposi's sarcoma associated herpesvirus (KSHV) are associated with AIDS related cancers and human cytomegalovirus (HCMV) with severe retinitis and pneumonitis in HIV-1 positive individuals...
  6. Inflammation and Cerebral Aneurysm Formation: Targets for Modulation and Vascular
    BRIAN LIM HOH; Fiscal Year: 2013
    ..Edward Mocarksi on a project studying regulation of the B2.7 promoter of human cytomegalovirus. As a medical student at Columbia University I worked under Dr...
  7. CSHL Eukaryotic DNA Replication Conference
    David J Stewart; Fiscal Year: 2013
    ..Xenopus and mammalian cells;(2) the replication of viral chromosomes, including SV40, polyomavirus, cytomegalovirus, herpesvirus, papillomaviruses, and Epstein-Barr virus;(3) control of DNA replication in the cell cycle;(4) ..
  8. Antisense Mediated Treatment of Hepatitis B Virus Infection
    STEFAN FRANK WIELAND; Fiscal Year: 2013
    ..pursued by our collaborator Isis Pharmaceuticals and resulted in a commercialized drug (fomivirsen) targeting cytomegalovirus. Using the same principal, our collaborators at Isis Pharmaceuticals have now identified lead candidate ..
  9. Novel vaccine to CMV based on a disc virus
    Alistair McGregor; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Cytomegalovirus (CMV) is a ubiquitous pathogen that causes significant morbidity and mortality in immunocompromised populations. Currently, there is no effective vaccine against CMV...
  10. Identification of Inhibitors that Stabilize ER Degradation Substrates
    Domenico Tortorella; Fiscal Year: 2012
    ..Human cytomegalovirus (HCMV) unique short (US)2 and US11 gene products have co-opted ERAD to mediate the destruction of the ..
  11. Development of a novel vaccine against congenital cytomegalovirus infection
    Christopher S Morello; Fiscal Year: 2010
    Congenital infection with human cytomegalovirus (HCMV) occurs in approximately 40,000 infants a year in the United States annually and is the leading viral cause of birth defects...
  12. Cytotoxic-T-Lymphocyte (CTL) Therapy of AML
    Bruce R Blazar; Fiscal Year: 2013
    ..Challenge of post-BMT recipients with Listeria monocytogenes, vesicular stomatitis virus or murine cytomegalovirus will be used to assess na[unreadable]ve and effector/memory responses to pathogens in BMT recipients after LN ..
  13. DC-SIGN Inhibitors for the Treatment of HIV Infection
    ALLEN BERNARD REITZ; Fiscal Year: 2013
    ..HIV-1 and HIV-2), simian immunodeficiency virus (SIV), dengue virus, Marburg virus, hepatitis C, Ebola, and cytomegalovirus. With respect to HIV-1 transmission, DC-SIGN has been shown to serve as ligand that efficiently binds, ..
  14. Tomotherapy and Hematopoietic Stem Cells For Tolerance to Kidney Transplants
    Samuel Strober; Fiscal Year: 2013
    ..virus vaccination after transplantation, as well as recall T cell responses to herpes zoster, herpes simplex, cytomegalovirus antigens, and tetanus toxoid...
  15. 2011 EUKARYOTIC DNA REPLICATION &GENOME MAINTENANCE
    David J Stewart; Fiscal Year: 2011
    ..Xenopus and mammalian cells;(2) the replication of viral chromosomes, including SV40, polyomavirus, cytomegalovirus, herpesvirus, papillomaviruses, and Epstein-Barr virus;(3) control of DNA replication in the cell cycle;(4) ..
  16. Development of a Novel Vaccine Against Herpes Simplex Type 2
    DEBORAH SPECTOR; Fiscal Year: 2009
    ..Recent studies of the natural immunity to another herpesvirus, murine cytomegalovirus (MCMV), have demonstrated that CD8 T cells specific for an immunodominant MCMV antigen are ineffective at ..
  17. Antiviral activity of leflunomide against respiratory syncytial virus
    WILLIAM WALDMAN; Fiscal Year: 2009
    ..This agent has been shown to exert powerful antiviral activity against cytomegalovirus in vitro and in vivo, and in preliminary in vitro and in vivo studies against RSV...
  18. Fetal HCMV Infection: Role of the Human Placenta
    LENORE PALMA PEREIRA; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Primary maternal human cytomegalovirus (HCMV) infection affects 1-3% of pregnancies and causes birth defects in 25% of congenitally infected babies...
  19. Transplant Associated Infection Surveillance Network Phase II
    PETER GEORGE PAPPAS; Fiscal Year: 2012
    ..e. C.difficile, cytomegalovirus, West Nile virus, respiratory viruses, and selected multiresistant bacteria);and 4) to establish a bank for ..
  20. Oral Immunobiology of MCMV-infected Mouse Salivary Glands
    Steven D London; Fiscal Year: 2010
    ..Murine cytomegalovirus (MCMV) infections have served as a tool for investigating salivary gland immunity...
  21. Modulation of Glioma Growth and Invasion by HCMV Glycoprotein B
    Liliana Soroceanu; Fiscal Year: 2010
    ..Our laboratory was the first to show that human cytomegalovirus (HCMV) nucleic acids and proteins are present in over 90% of human malignant gliomas, and these findings have ..
  22. Alteration of ER:mitochondrial contacts by human cytomegalovirus infection
    ANAMARIS MARTHA COLBERG POLEY; Fiscal Year: 2010
    Human cytomegalovirus (HCMV), like other viruses, exploits host cell machineries and, in doing so, provides powerful tools for gaining insight into cellular regulatory mechanisms...
  23. CD8+ T Cell Immunity to Cytomegalovirus
    Stanley R Riddell; Fiscal Year: 2013
    Reactivation of latent cytomegalovirus (CMV) occurs frequently in immunosuppressed recipients of allogeneic hematopoietic stem cell transplant (HCT) as a consequence of deficient T cell immunity, and is responsible for substantial ..
  24. Confirmatory Screening for Congenital Non-Syndromic Genetic Hearing Loss Using Ta
    Edwin W Naylor; Fiscal Year: 2013
    ..Infants may also be born with hearing loss caused by a viral infection like cytomegalovirus (CMV) that was acquired during pregnancy...
  25. Human Population Diversity in Leukocyte Receptors
    PETER R PARHAM; Fiscal Year: 2013
    ..specificity for HLA class I, complementing those of the KIR, that is subverted by the UL18 protein of human cytomegalovirus to prevent the killing of virus-infected cells...
  26. Repair of HCMV-Induced DNA Damage in Infected Cells
    Elizabeth A Fortunato; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Human Cytomegalovirus (HCMV) is a leading cause of birth defects...
  27. Regulation of CD8 T Cell Immunity by CDK Inhibitor p27Kip1
    Marulasiddappa Suresh; Fiscal Year: 2012
    ..play a crucial role in defense against viral infections like HIV, hepatitis B and C, Epstein Barr virus, cytomegalovirus, and arenaviruses...
  28. Programmed necrosis in Immune Responses
    Francis Ka Ming Chan; Fiscal Year: 2013
    ..programmed necrosis, such as certain viral FLIPs (FLICE(caspase-8)-like inhibitor proteins) and the mouse cytomegalovirus (MCMV) M45 protein...
  29. Ribozymes for studies and treatment of cytomegalovirus infections
    Fenyong Liu; Fiscal Year: 2012
    Human cytomegalovirus (HCMV) causes one of the most common opportunistic infections in patients with AIDS...
  30. ANTIGEN SPECIFIC T CELL TOLERANCE BY ANTI CD3 ANTIBODIES
    Claudio Anasetti; Fiscal Year: 2012
    ..therapy depletes the alloreactive T cell pool, while sparing immunity to third party alloantigens, cytomegalovirus (CMV) and Epstein-Barr virus (EBV), and tumor- associated antigen WT1...
  31. Disruption of Neural Stem Cell Homeostasis by Cytomegalovirus
    DEBORAH HYE SPECTOR; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Human cytomegalovirus (HCMV) is the major viral cause of birth defects and affects the central nervous system...
  32. Down-regulation of MHC class l molecules by HCMV US2
    Domenico Tortorella; Fiscal Year: 2009
    DESCRIPTION (provided by the applicant): Human cytomegalovirus (HCMV) is a beta-herpes virus that can establish persistence and latent infections...
  33. Effect of alcohol exposure on human Treg induction &CD36HI monocyte biology
    KATHLEEN ELIZABETH JAEGER; Fiscal Year: 2013
    ..limited to, meningitis, pneumonia and sepsis, as well as increased viral infections caused by agents such as cytomegalovirus and influenza...
  34. Viral Immunomodulation and Rational CMV Vaccine Design
    Mark R Schleiss; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The development of a vaccine against human cytomegalovirus (HCMV) is a major public health priority...
  35. Role of IL-15 in CD8 T Cell Development and Response
    Leo Lefrancois; Fiscal Year: 2011
    ..The unique characteristics of mouse cytomegalovirus (MCMV)-specific memory CD8 T cells along with preliminary data showing divergent memory dysregulation in IL-..
  36. Retinal Iron Homeostasis in Health and Disease
    Vadivel Ganapathy; Fiscal Year: 2013
    ..expression of Hfe, Hjv, and hepcidin is markedly altered in RPE and in retina as a result of infection with cytomegalovirus (CMV) and herpes simplex virus-1 (HSV1)...
  37. ASSEMBLY OF MHC CLASS I MOLECULES IN VITRO AND IN VIVO
    Hidde L Ploegh; Fiscal Year: 2012
    ..Herpesviruses, in particular human cytomegalovirus (HCMV), display immunoevasive behavior that contributes to their pathogenicity...
  38. MOUSE MODELS FOR UNDERSTANDING HOST RESPONES TO INTRACELLULAR PATHOGENS
    Ellen A Robey; Fiscal Year: 2010
    ..gondii, Influenza, Vaccinia, Lymphocytic Choriomeningitis virus) and other pathogens (Murine &Human cytomegalovirus, Murine herpes virus 68, Moloney Murine Leukemia Virus, Kaposi's Sarcoma Herpes Virus, Mouse Hepatitis ..
  39. CHARACTERIZATION OF HCMV UL84
    Gregory S Pari; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Human cytomegalovirus (HCMV) is a beta herpesvirus that is normally asymptomatic in immune- competent hosts...
  40. CYTOMEGALOVIRUS DNA REPLICATION AND INVERSION
    Edward S Mocarski; Fiscal Year: 2013
    Human cytomegalovirus (CMV) remains a major cause of congenital disease in children as well as a significant opportunistic pathogen in immunocompromised individuals, causing acute and chronic disease consequences despite the use of ..
  41. The role of CEACAM1 in CMV pathogenesis in the human placenta
    Takako Tabata; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Human cytomegalovirus (CMV) is the leading viral cause of birth defects in the United States...
  42. Vertical CMV transmission in the setting of maternal HIV-1 infection in Kenya
    JENNIFER ANN SLYKER; Fiscal Year: 2013
    ..Research: There is evidence that cytomegalovirus (CMV) infection contributes significantly to morbidity and mortality in HIV-1 infected infants...
  43. TRANSLATIONAL CONTROL OF CYTOMEGALOVIRUS GENE EXPRESSION
    Adam P Geballe; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Human cytomegalovirus (HCMV) causes considerable morbidity and mortality in newborns and immunocompromised patients and may have subtle but widespread health effects in the large fraction of humans ..
  44. Human Cytomegalovirus-Induced Inhibition of Cytotrophoblast Invasion
    CINDY ANNE MORRIS; Fiscal Year: 2012
    ..morbidity and mortality is associated with symptomatic congenital infection with the herpes virus human cytomegalovirus (HCMV)...
  45. MOLECULAR GENETICS OF HSV DNA POLYMERASE GENE
    James M Hogle; Fiscal Year: 2013
    ..and different manners by which the accessory subunits, such as herpes simplex virus (HSV) UL42 and human cytomegalovirus (HCMV) UL44, interact with DNA so that they bind tightly, yet diffuse linearly along the DNA to permit ..
  46. Bacteria Based Agents for Therapy of AIDS Associated Infections
    Sangwei Lu; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Human cytomegalovirus (HCMV) causes one of the most common opportunistic infections in patients with AIDS...
  47. ASSEMBLY OF THE HERPES SIMPLEX VIRUS CAPSID
    Jay C Brown; Fiscal Year: 2012
    ..be able to be exploited for the design of therapeutics effective against other herpesviruses including human cytomegalovirus, Epstein- Barr virus and Kaposi's sarcoma-associated herpesvirus...
  48. Role of CMV kinase in regulating infection of ESC-derived neuroprogenitor cells
    Tarin M Bigley; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Human cytomegalovirus (CMV) is the most common cause of non-hereditary sensorineural hearing loss in the U.S. Current therapies to treat infection during pregnancy or upon birth are unproven and risky...
  49. Attenuated RhCMV Delta 10 SIV Oral Vaccine Vectors Encoding TLR5 Ligand Sequences
    ELLEN ELIZABETH SPARGER; Fiscal Year: 2013
    ..the nonhuman primate model for human immunodeficiency virus (HIV), we propose to utilize an attenuated rhesus cytomegalovirus (RhCMV) vaccine vector developed in our laboratories for oral delivery of a simian immunodeficiency virus (..
  50. Anti-viral and antileukemic T-cell therapy as prophylaxis after HSCT
    Helen E Heslop; Fiscal Year: 2013
    ..Our center has developed a novel approach that effectively expands cytotoxic T lymphocytes (CTL) specific for cytomegalovirus, Epstein-Barr virus and adenoviruses from T- cells in a single culture...
  51. Role of B-cells and CNS antibodies in modulating chronic microglial activation
    James R Lokensgard; Fiscal Year: 2013
    ..Using a murine cytomegalovirus (MCMV) model of viral brain infection, we were surprised to detect numerous CD19(-)CD38(+)CD138(+) plasma ..
  52. RASCAL: a new tropism determinant encoded by human cytomegalovirus?
    Laura Hertel; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The exceptionally broad tissue tropism of human cytomegalovirus (CMV) is a substantial contributor to the severe multi-organ disease caused by this virus in immune compromised individuals...
  53. Chronic CMV infection in the elderly: diagnosis and link to chronic inflammation
    Sean X Leng; Fiscal Year: 2013
    ..Studies have reported clonal expansion of cytomegalovirus (CMV)-specific T cells in CMV-seropositive older persons and associations of CMV seropositivity or absolute ..
  54. Therapeutic Antibodies for CMV
    WILLIAM ROBERT USINGER; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Human cytomegalovirus (HCMV) is the major viral cause of birth defects and of medical complications associated with organ transplantation...
  55. Retinoblastoma (Rb) protein pathway in human cytomegalovirus infected cells
    Robert F Kalejta; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Human cytomegalovirus (HCMV) is a ubiquitous and significant pathogen that stimulates cell cycle progression...
  56. Bacteria Based Agents for Therapy of AIDS Associated Infections
    Sangwei Lu; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Human cytomegalovirus (HCMV) causes one of the most common opportunistic infections in patients with AIDS...
  57. Anti Herpesvirus Signaling by LTab and LIGHT
    Carl F Ware; Fiscal Year: 2013
    ..LT?R is a critical pathway for the initial induction of the type I IFN (IFN??) in response to human or mouse cytomegalovirus. In mice, the LT-IFN axis is essential for lymphocyte survival during CMV infection and is mediated between ..
  58. The Immune Pathogenesis of Prenatal Listeria monocytogenes Infection
    Sing Sing Way; Fiscal Year: 2013
    ..coli, Group B Streptococcus, Salmonella, Chlamydia and cytomegalovirus each have a defined predisposition for prenatal infection that often results in spontaneous abortion or ..
  59. CMV 2012 - combined 4th Congenital Cytomegalovirus Conference and 14th Internatio
    DEBORAH HYE SPECTOR; Fiscal Year: 2012
    Description (as provided by the applicant): Human cytomegalovirus (HCMV) is the major viral cause of birth defects, and its impact on health care costs is enormous...
  60. Alternative antiviral drug targets for human cytomegalovirus infection
    Sunwen Chou; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Human cytomegalovirus (CMV) is a leading opportunistic viral pathogen, causing invasive disease such as retinitis, pneumonia, colitis and encephalitis in the immunocompromised...
  61. Role of Toll-like Receptors in Transplant-Induced Reactivation of Cytomegalovirus
    Michael Abecassis; Fiscal Year: 2010
    Reactivation of latent cytomegalovirus (CMV) is frequently observed in recipients of solid organs and bone marrow transplants and is also a significant cause of morbidity and mortality in newborns and in immunocompromised hosts...
  62. Human Cytomegalovirus Nuclear Egress: Molecular Mechanisms and Drug Targeting
    James M Hogle; Fiscal Year: 2013
    ..applicant): This application's long-term objectives are to understand the central steps by which human cytomegalovirus (HCMV) nucleocapsids transit from the nucleus to the cytoplasm (nuclear egress), and to exploit that ..
  63. Role of the Human Cytomegalovirus UL97 Proein Kinase in Viral Replication
    JEREMY KAMIL; Fiscal Year: 2009
    This application aims to investigate the role of the UL97 protein kinase of human cytomegalovirus (HCMV) in viral replication, with an explicit focus on nuclear egress...
  64. Cytomegalovirus infection of blood vessels
    Fenyong Liu; Fiscal Year: 2005
    Human cytomegalovirus (HCMV) causes one of the most common opportunistic infections in immunocompromised individuals, including organ transplant recipients and AIDS patients...
  65. Ab Alphavirus Replicon Vaccine against Cytomegalovirus
    Robert Esch; Fiscal Year: 2005
    ..of the proposed research are to develop further an alphavirus replicon particle vaccine against human cytomegalovirus (CMV)...
  66. Novel 3-D Model of Placental Cytomegalovirus Infection
    Cindy Morris; Fiscal Year: 2006
    The overall objective of this proposal is to develop an improved tissue model for the study of human cytomegalovirus infection (CMV) during pregnancy...
  67. Treatment of Cytomegalovirus by Inhibition of Host Lipid Synthesis
    Bryson D Bennett; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Cytomegalovirus (CMV) causes significant disease and mortality in populations with weakened immune systems, including cancer patients, organ transplant recipients, and HIV-infected people...
  68. LIVER TRANSPLANT ASSOCIATED CYTOMEGALOVIRUS PREVENTION
    David Snydman; Fiscal Year: 1991
    b>Cytomegalovirus (CMV) is the single most significant viral infection complicating liver transplantation. CMV increases the mortality of liver transplant patients and may contribute to complicating fungal or parasitic superinfection...
  69. MOLECULAR STUDIES OF HUMAN CYTOMEGALOVIRUS PROTEASE
    Liang Tong; Fiscal Year: 2003
    DESCRIPTION: (Adapted from Applicant's Abstract) Human cytomegalovirus (HCMV), a herpesvirus, is a major opportunistic infectious agent in individuals suffering from AIDS, as well as individuals with suppressed immune systems (for ..
  70. Human Cytomegalovirus Nuclear Egress: Molecular Mechanisms and Drug Targeting
    Donald Coen; Fiscal Year: 2009
    ..health-related, as new drugs are needed for treatment of herpesvirus infections, particularly those of human cytomegalovirus (HCMV)...
  71. A POTENT ORAL THERAPY FOR CYTOMEGALOVIRUS INFECTION
    Terry Bowlin; Fiscal Year: 2009
    b>Cytomegalovirus (CMV) infection represents a major health concern in the immunocompromised population, especially recipients of bone marrow and solid-organ transplants...
  72. Guinea pig cytomegalovirus as a model for vaccines that target endocytic entry
    Michael A McVoy; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Human cytomegalovirus (HCMV) is the major infectious cause of birth defects in the United States. Development of a vaccine to prevent HCMV-associated birth defects has been deemed a national priority...
  73. HUMAN CYTOMEGALOVIRUS DNA CLEAVAGE AND PACKAGING
    Michael McVoy; Fiscal Year: 2005
    ..simplex virus, varicella-zoster virus, Epstein-Barr virus, Kaposi's sarcoma associated herpesvirus, and human cytomegalovirus (HCMV)...
  74. The role of cytomegalovirus antiapoptotic proteins in replication in macrophages.
    ANITA LOUISE MCCORMICK; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Human cytomegalovirus (HCMV) is a highly prevalent herpesvirus efficiently transmitted by transfusion or transplantation...