garcinia mangostana

Summary

Summary: A plant genus of the family CLUSIACEAE. It is the source of the mangosteen fruit.

Top Publications

  1. ncbi Antimycobacterial activity of prenylated xanthones from the fruits of Garcinia mangostana
    Sunit Suksamrarn
    Department of Chemistry, Faculty of Science, Srinakharinwirot University, Bangkok, Thailand
    Chem Pharm Bull (Tokyo) 51:857-9. 2003
  2. ncbi Xanthones and benzophenones from Garcinia griffithii and Garcinia mangostana
    Lien Hoa D Nilar Nguyen
    Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543, Republic of Singapore
    Phytochemistry 66:1718-23. 2005
  3. ncbi Antioxidant xanthones from the pericarp of Garcinia mangostana (Mangosteen)
    Hyun Ah Jung
    Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, Ohio 43210, USA
    J Agric Food Chem 54:2077-82. 2006
  4. ncbi Medicinal properties of mangosteen (Garcinia mangostana)
    José Pedraza-Chaverri
    Facultad de Quimica, Departamento de Biologia, Universidad Nacional Autonoma de Mexico, Ciudad Universitaria, 04510 Mexico, DF, Mexico
    Food Chem Toxicol 46:3227-39. 2008
  5. ncbi Effect of Garcinia mangostana on inflammation caused by Propionibacterium acnes
    Mullika Traidej Chomnawang
    Department of Microbiology, Faculty of Pharmacy, Mahidol University, Rachathevi, Bangkok, Thailand
    Fitoterapia 78:401-8. 2007
  6. ncbi Anti-inflammatory activity of mangostins from Garcinia mangostana
    Lih Geeng Chen
    Graduate Institute of Biomedical and Biopharmaceutical Sciences, College of Life Sciences, National Chiayi University, 300 University Road, Chiayi 600, Taiwan, ROC
    Food Chem Toxicol 46:688-93. 2008
  7. ncbi Cardioprotective effect of alpha-mangostin, a xanthone derivative from mangosteen on tissue defense system against isoproterenol-induced myocardial infarction in rats
    Pandima Devi Sampath
    Centre for Advanced Studies in Botany, University of Madras, Guindy Campus, Chennai, India
    J Biochem Mol Toxicol 21:336-9. 2007
  8. ncbi Antibacterial activity of alpha-mangostin against vancomycin resistant Enterococci (VRE) and synergism with antibiotics
    Y Sakagami
    Osaka Prefectural Institute of Public Health, Osaka, Japan
    Phytomedicine 12:203-8. 2005
  9. ncbi Antifungal activity of alpha-mangostin against Candida albicans
    Ruchadaporn Kaomongkolgit
    Oral Diagnosis Department, Faculty of Dentistry, Naresuan University, Phitsanulok, Thailand
    J Oral Sci 51:401-6. 2009
  10. pmc α-Mangostin, a xanthone from mangosteen fruit, promotes cell cycle arrest in prostate cancer and decreases xenograft tumor growth
    Jeremy J Johnson
    Department of Pharmacy Practice, University of Illinois at Chicago College of Pharmacy, 833 South Wood Street, Chicago, IL 60612 7230, USA
    Carcinogenesis 33:413-9. 2012

Research Grants

Scientific Experts

Detail Information

Publications127 found, 100 shown here

  1. ncbi Antimycobacterial activity of prenylated xanthones from the fruits of Garcinia mangostana
    Sunit Suksamrarn
    Department of Chemistry, Faculty of Science, Srinakharinwirot University, Bangkok, Thailand
    Chem Pharm Bull (Tokyo) 51:857-9. 2003
    Prenylated xanthones, isolated from the fruit hulls and the edible arils and seeds of Garcinia mangostana, were tested for their antituberculosis potential...
  2. ncbi Xanthones and benzophenones from Garcinia griffithii and Garcinia mangostana
    Lien Hoa D Nilar Nguyen
    Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543, Republic of Singapore
    Phytochemistry 66:1718-23. 2005
    ..The acetone extract of the heartwood of Garcinia mangostana contained one new diprenylated xanthone (mangoxanthone) and a new benzophenone (3',6-dihydroxy-2,4,4'-..
  3. ncbi Antioxidant xanthones from the pericarp of Garcinia mangostana (Mangosteen)
    Hyun Ah Jung
    Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, Ohio 43210, USA
    J Agric Food Chem 54:2077-82. 2006
    As part of ongoing research on cancer chemopreventive agents from botanical dietary supplements, Garcinia mangostana L. (commonly known as mangosteen) was selected for detailed study...
  4. ncbi Medicinal properties of mangosteen (Garcinia mangostana)
    José Pedraza-Chaverri
    Facultad de Quimica, Departamento de Biologia, Universidad Nacional Autonoma de Mexico, Ciudad Universitaria, 04510 Mexico, DF, Mexico
    Food Chem Toxicol 46:3227-39. 2008
    Many tropical plants have interesting biological activities with potential therapeutic applications. Garcinia mangostana Linn. (GML) belongs to the family of Guttiferae and is named "the queen of fruits"...
  5. ncbi Effect of Garcinia mangostana on inflammation caused by Propionibacterium acnes
    Mullika Traidej Chomnawang
    Department of Microbiology, Faculty of Pharmacy, Mahidol University, Rachathevi, Bangkok, Thailand
    Fitoterapia 78:401-8. 2007
    ..Antioxidant activity was determined by DPPH scavenging and NBT reduction assay. The result showed that Garcinia mangostana possessed the most significant antioxidant activity and reduced reactive oxygen species production...
  6. ncbi Anti-inflammatory activity of mangostins from Garcinia mangostana
    Lih Geeng Chen
    Graduate Institute of Biomedical and Biopharmaceutical Sciences, College of Life Sciences, National Chiayi University, 300 University Road, Chiayi 600, Taiwan, ROC
    Food Chem Toxicol 46:688-93. 2008
    The fruit hull of Garcinia mangostana Linn (Guttiferae) is used as an anti-inflammatory drug in Southeast Asia. Two xanthones, alpha- and gamma-mangostins, were isolated from the fruit hull of G...
  7. ncbi Cardioprotective effect of alpha-mangostin, a xanthone derivative from mangosteen on tissue defense system against isoproterenol-induced myocardial infarction in rats
    Pandima Devi Sampath
    Centre for Advanced Studies in Botany, University of Madras, Guindy Campus, Chennai, India
    J Biochem Mol Toxicol 21:336-9. 2007
    ..These findings indicate the protective effect of alpha-mangostin on lipid peroxidation and antioxidant tissue defense system during ISO-induced myocardial infarction in rats...
  8. ncbi Antibacterial activity of alpha-mangostin against vancomycin resistant Enterococci (VRE) and synergism with antibiotics
    Y Sakagami
    Osaka Prefectural Institute of Public Health, Osaka, Japan
    Phytomedicine 12:203-8. 2005
    alpha-Mangostin, isolated from the stem bark of Garcinia mangostana L., was found to be active against vancomycin resistant Enterococci (VRE) and methicillin resistant Staphylococcus aureus (MRSA), with MIC values of 6.25 and 6.25 to 12...
  9. ncbi Antifungal activity of alpha-mangostin against Candida albicans
    Ruchadaporn Kaomongkolgit
    Oral Diagnosis Department, Faculty of Dentistry, Naresuan University, Phitsanulok, Thailand
    J Oral Sci 51:401-6. 2009
    ..The strong antifungal activity and low toxicity of alpha-mangostin make it a promising agent for treatment of oral candidiasis...
  10. pmc α-Mangostin, a xanthone from mangosteen fruit, promotes cell cycle arrest in prostate cancer and decreases xenograft tumor growth
    Jeremy J Johnson
    Department of Pharmacy Practice, University of Illinois at Chicago College of Pharmacy, 833 South Wood Street, Chicago, IL 60612 7230, USA
    Carcinogenesis 33:413-9. 2012
    ..01). The ability of α-mangostin to inhibit PCa in vitro and in vivo suggests α-mangostin may be a novel agent for the management of PCa...
  11. ncbi Panaxanthone isolated from pericarp of Garcinia mangostana L. suppresses tumor growth and metastasis of a mouse model of mammary cancer
    Hitoshi Doi
    Department of Anatomy and Cell Biology, Osaka Medical College, Takatsuki, Osaka 569 8686, Japan
    Anticancer Res 29:2485-95. 2009
    ....
  12. ncbi Garcinia mangostana L.: a phytochemical and pharmacological review
    Dmitriy Obolskiy
    Center for Pharmacognosy and Phytotherapy, The School of Pharmacy University of London, 29 39 Brunswick Square, London WC1N 1AX, UK
    Phytother Res 23:1047-65. 2009
    b>Garcinia mangostana L. (mangosteen, Clusiaceae) has a long history of use as a medical plant, mostly in Southeast Asia. This is a review of the phytochemistry and pharmacology of mangosteen...
  13. pmc Xanthones from mangosteen extracts as natural chemopreventive agents: potential anticancer drugs
    T Shan
    Department of Hepatobiliary Surgery, First Affiliated Hospital of Medical College, Xi an Jiaotong University, Xi an 710061, Shaanxi, China
    Curr Mol Med 11:666-77. 2011
    ..Xanthones, from the pericarp, whole fruit, heartwood, and leaf of mangosteen (Garcinia mangostana Linn...
  14. pmc Evaluation of Mangosteen juice blend on biomarkers of inflammation in obese subjects: a pilot, dose finding study
    Jay K Udani
    Medicus Research LLC, Northridge, CA 91325, USA
    Nutr J 8:48. 2009
    ..The purpose of this study was to evaluate the effect of multiple dosages of a proprietary Mangosteen Juice blend on indicators of inflammation and antioxidant levels in obese patients with elevated C-reactive protein (CRP) levels...
  15. ncbi Quantitative and qualitative determination of six xanthones in Garcinia mangostana L. by LC-PDA and LC-ESI-MS
    Xiuhong Ji
    National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, The University of Mississippi, University, MS 38677, USA
    J Pharm Biomed Anal 43:1270-6. 2007
    ..The developed methods were applied to the determination of six xanthones in Garcinia mangostana products. The satisfactory results showed that the methods are effective for the analysis of real samples.
  16. ncbi Fatty acid synthase inhibitors of phenolic constituents isolated from Garcinia mangostana
    He Zhong Jiang
    State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, China
    Bioorg Med Chem Lett 20:6045-7. 2010
    ..The bioassay-guided chemical investigation of the hulls of Garcinia mangostana led to the isolation of 13 phenolic compounds (1-13) mainly including xanthone and benzophenone, in which ..
  17. ncbi Xanthone constituents of the fruits of Garcinia mangostana with anticomplement activity
    Gui Hua Quan
    Immune Modulators Research Center, Korea Research Institute of Bioscience and Biotechnology, 685 1 Ochangeup, Cheongwongun, Chungbuk 363 883, South Korea
    Phytother Res 24:1575-7. 2010
    Phytochemical investigation of a chloroform-soluble fraction of the freeze-dried fruits of Garcinia mangostana (Clusiaceace) with anticomplement activity in the classical pathway led to the identification of five known xanthones...
  18. ncbi Inhibitory effect of xanthones isolated from the pericarp of Garcinia mangostana L. on rat basophilic leukemia RBL-2H3 cell degranulation
    Tomohiro Itoh
    Gifu International Institute of Biotechnology, Bio active Substances Research, 1 1 Naka fudogaoka, Kakamigahara, Gifu 504 0838, Japan
    Bioorg Med Chem 16:4500-8. 2008
    Mangostin, Garcinia mangostana L. is used as a traditional medicine in southeast Asia for inflammatory and septic ailments...
  19. ncbi Topical application of Garcinia mangostana L. pericarp gel as an adjunct to periodontal treatment
    Supanee Rassameemasmaung
    Department of Oral Medicine, Faculty of Dentistry, Mahidol University, Ratchathewi, Bangkok 10400, Thailand
    Complement Ther Med 16:262-7. 2008
    To evaluate the effects of gel containing Garcinia mangostana L. pericarp extract (GM gel) applied topically as an adjunct to periodontal treatment.
  20. ncbi Effect of a mangosteen dietary supplement on human immune function: a randomized, double-blind, placebo-controlled trial
    Yu Ping Tang
    Department of Preventive Medicine, Yanjing Medical School, School of Public Health and Family Medicine, Capital Medical University, Beijing
    J Med Food 12:755-63. 2009
    ..001). The results indicated that the intake of an antioxidant-rich product significantly enhanced immune responses and improved the subject's self-appraisal on his or her overall health status...
  21. ncbi Apoptotic effects of γ-mangostin from the fruit hull of Garcinia mangostana on human malignant glioma cells
    Hui Fang Chang
    Department of Pharmacognosy, School of Pharmacy, College of Pharmacy, and Center of e CAM, Taipei Medical University, 250 Wusing St, Taipei 110, Taiwan
    Molecules 15:8953-66. 2010
    ..effects of γ-mangostin, a xanthone derivative isolated and purified from the hull of the tropical fruit Garcinia mangostana. The γ-mangostin showed potent antiproliferative activity toward MGs in dose- and time-dependent manners...
  22. pmc Xanthones from the botanical dietary supplement mangosteen (Garcinia mangostana) with aromatase inhibitory activity
    Marcy J Balunas
    Department of Medicinal Chemistry and Pharmacognosy, Program for Collaborative Research in the Pharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    J Nat Prod 71:1161-6. 2008
    Twelve xanthone constituents of the botanical dietary supplement mangosteen (the pericarp of Garcinia mangostana) were screened using a noncellular, enzyme-based microsomal aromatase inhibition assay...
  23. ncbi Ameliorative prospective of alpha-mangostin, a xanthone derivative from Garcinia mangostana against beta-adrenergic cathecolamine-induced myocardial toxicity and anomalous cardiac TNF-alpha and COX-2 expressions in rats
    Pandima Devi Sampath
    Centre for Advanced Studies in Botany, University of Madras, Guindy Campus, Chennai, India
    Exp Toxicol Pathol 60:357-64. 2008
    ..Restoration of cellular normalcy accredits the cytoprotective role of alpha-mangostin...
  24. pmc Cytotoxic xanthone constituents of the stem bark of Garcinia mangostana (mangosteen)
    Ah Reum Han
    College of Pharmacy, The Ohio State University, Columbus, Ohio 43210, USA
    J Nat Prod 72:2028-31. 2009
    Bioassay-guided fractionation of a chloroform-soluble extract of Garcinia mangostana stem bark, using the HT-29 human colon cancer cell line and an enzyme-based ELISA NF-kappaB assay, led to the isolation of a new xanthone, 11-hydroxy-3-..
  25. ncbi Xanthones from mangosteen inhibit inflammation in human macrophages and in human adipocytes exposed to macrophage-conditioned media
    Akkarach Bumrungpert
    Department of Nutrition, Faculty of Public Health, Mahidol University, Bangkok, Thailand
    J Nutr 140:842-7. 2010
    ....
  26. ncbi Effects of compounds from Garcinia mangostana on inflammatory mediators in RAW264.7 macrophage cells
    Supinya Tewtrakul
    Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand
    J Ethnopharmacol 121:379-82. 2009
    The fruit hull of Garcinia mangostana Linn. has been used in Thai traditional medicine for treatment of abscess and skin infection.
  27. ncbi A MYB transcription factor regulates anthocyanin biosynthesis in mangosteen (Garcinia mangostana L.) fruit during ripening
    Yossapol Palapol
    Department of Horticulture, Faculty of Agriculture, Kasetsart University, Bangkok, 10900, Thailand
    Planta 229:1323-34. 2009
    Mangosteen (Garcinia mangostana L.) fruit undergo rapid red colour development, both on the tree and after harvest, resulting in high anthocyanin production in the pericarp...
  28. ncbi Antioxidative and neuroprotective activities of extracts from the fruit hull of mangosteen (Garcinia mangostana Linn.)
    Wanlop Weecharangsan
    Faculty of Pharmacy, Silpakorn University, Nakhonpathom, Thailand
    Med Princ Pract 15:281-7. 2006
    The aim of this study was to investigate the antioxidative and neuroprotective activities of various extracts from the fruit hull of mangosteen (Garcinia mangostana Linn., GM).
  29. ncbi Inhibition of cyclooxygenase and prostaglandin E2 synthesis by gamma-mangostin, a xanthone derivative in mangosteen, in C6 rat glioma cells
    Keigo Nakatani
    Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku University, Aoba, Aramaki, Aoba ku, 980 8578, Sendai, Japan
    Biochem Pharmacol 63:73-9. 2002
    The fruit hull of mangosteen, Garcinia mangostana L., has been used for many years as a medicine for treatment of skin infection, wounds, and diarrhea in Southeast Asia...
  30. pmc Doxorubicin-induced central nervous system toxicity and protection by xanthone derivative of Garcinia mangostana
    J Tangpong
    School of Allied Health Sciences and Public Health, Thasala, Nakhon Si Thammarat, Thailand
    Neuroscience 175:292-9. 2011
    ..The present study tested the protective effect of a xanthone derivative of Garcinia Mangostana against Dox-induced neuronal toxicity...
  31. ncbi Inhibitions of histamine release and prostaglandin E2 synthesis by mangosteen, a Thai medicinal plant
    Keigo Nakatani
    Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan
    Biol Pharm Bull 25:1137-41. 2002
    The fruit hull of mangosteen, Garcinia mangostana L. has been used as a Thai indigenous medicine for many years. However, its mechanism of action as a medicine has not been elucidated...
  32. ncbi Inhibitory effects of crude alpha-mangostin, a xanthone derivative, on two different categories of colon preneoplastic lesions induced by 1, 2-dimethylhydrazine in the rat
    Viengvansay Nabandith
    Tumor Pathology Division, Faculty of Medicine, University of the Ryukyus, Okinawa 903 0215, Japan
    Asian Pac J Cancer Prev 5:433-8. 2004
    ..study was to examine whether crude alpha-mangostin (a major xanthone derivative in mangosteen pericarp (Garcinia mangostana)) has short-term chemopreventive effects on putative preneoplastic lesions involved in rat colon ..
  33. ncbi Comparative study of health properties and nutritional value of durian, mangosteen, and snake fruit: experiments in vitro and in vivo
    Ratiporn Haruenkit
    Faculty of Agricultural Industry and Department of Soil Science, King Mongkut s Institute of Technology Ladkrabang, Ladkrabang, Bangkok 10520, Thailand
    J Agric Food Chem 55:5842-9. 2007
    ..were compared with snake fruit (Salacca edulis Reinw.) and mangosteen (Garcinia mangostana). Dietary fibers, minerals, and trace metals were comparable...
  34. ncbi What are the facts and myths about mangosteen?
    Wendy Marcason
    American Dietetic Association s Knowledge Center, Chicago, IL, USA
    J Am Diet Assoc 106:986. 2006
  35. ncbi Systematic analysis of in vitro photo-cytotoxic activity in extracts from terrestrial plants in Peninsula Malaysia for photodynamic therapy
    Cheng Yi Ong
    Cancer Research Initiatives Foundation CARIF, Subang Jaya Medical Centre, 1, Jalan SS12 1A, 47500 Subang Jaya, Selangor Darul Ehsan, Malaysia
    J Photochem Photobiol B 96:216-22. 2009
    ..Irvingiaceae), Knema curtisii (Myristicaceae), Dysoxylum sericeum (Meliaceae), Garcinia atroviridis, Garcinia mangostana and Calophyllum inophyllum (Clusiaceae), Ervatamia hirta (Apocynaceae), Cassia alata, Entada phaseoloides ..
  36. ncbi Berry fruits: compositional elements, biochemical activities, and the impact of their intake on human health, performance, and disease
    Navindra P Seeram
    Center for Human Nutrition, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    J Agric Food Chem 56:627-9. 2008
    ..the pomegranate ( Punica granatum), goji berries ( Lycium barbarum; also known as wolfberry), mangosteen ( Garcinia mangostana), the Brazilian açaí berry ( Euterpe oleraceae), and the Chilean maqui berry ( Aristotelia chilensis)...
  37. ncbi Field suppression of the invasive ant Wasmannia auropunctata (Hymenoptera: Formicidae) in a tropical fruit orchard in Hawaii
    Evann Souza
    Tropical Conservation Biology and Environmental Science Program, University of Hawaii at Hilo, Hilo, HI96720, USA
    J Econ Entomol 101:1068-74. 2008
    ..auropunctata in a rambutan, Nephelium lappaceum L. and mangosteen, Garcinia mangostana L., orchard by making treatments every 2 wk for 16 wk...
  38. ncbi Enhanced growth of lactobacilli in soymilk upon immobilization on agrowastes
    Sue Siang Teh
    School of Industrial Technology, Univ Sains Malaysia, 11800 Penang, Malaysia
    J Food Sci 75:M155-64. 2010
    ..the effects of agrowastes from durian (Durio zibethinus), cempedak (Artocarpus champeden), and mangosteen (Garcinia mangostana) as immobilizers for lactobacilli grown in soymilk...
  39. ncbi Xanthones with neuraminidase inhibitory activity from the seedcases of Garcinia mangostana
    Hyung Won Ryu
    Division of Applied Life Science BK21 program, EB NCRC, Institute of Agriculture and Life Science, Graduate School of Gyeongsang National University, Jinju 660 701, Republic of Korea
    Bioorg Med Chem 18:6258-64. 2010
    ..A series of xanthones 1-12 was isolated from the seedcases of Garcinia mangostana and evaluated for bacteria neuraminidase inhibitory activity...
  40. pmc Anti-cancer effects of xanthones from pericarps of mangosteen
    Yukihiro Akao
    Gifu International Institute of Biotechnology, 1 1 Naka fudogaoka, Kakamigahara, Gifu 504 0838, Japan Tel 81 583 71 4646
    Int J Mol Sci 9:355-70. 2008
    Mangosteen, Garcinia mangostana Linn, is a tree found in South East Asia, and its pericarps have been used as traditional medicine...
  41. ncbi Xanthones from Garcinia mangostana (Guttiferae)
    G C L Ee
    Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia
    Nat Prod Res 20:1067-73. 2006
    Studies on the stem of Garcinia mangostana have led to the isolation of one new xanthone mangosharin (1) (2,6-dihydroxy-8-methoxy-5-(3-methylbut-2-enyl)-xanthone) and six other prenylated xanthones, alpha-mangostin (2), beta-mangostin (3)..
  42. ncbi Activity of mangosteen xanthones and teleocidin a-2 in death receptor expression enhancement and tumor necrosis factor related apoptosis-inducing ligand assays
    Hiroyuki Kikuchi
    Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 263 8522, Japan
    J Nat Prod 73:452-5. 2010
    ..5 (DR5) expression was carried out, and bioassay-guided fractionation of two organisms, the pericarp of Garcinia mangostana (mangosteen) and actinomycete CKK609 strain, led to the isolation of eight xanthone derivatives (1-8) and ..
  43. ncbi Antiproliferation, antioxidation and induction of apoptosis by Garcinia mangostana (mangosteen) on SKBR3 human breast cancer cell line
    Primchanien Moongkarndi
    Department of Microbiology, Faculty of Pharmacy, Mahidol University, Sri Ayudthaya Road, Rajdhevee, Bangkok 10400, Thailand
    J Ethnopharmacol 90:161-6. 2004
    ..apoptotic and antioxidative properties of crude methanolic extract (CME) from the pericarp of Garcinia mangostana (family Guttiferae) using human breast cancer (SKBR3) cell line as a model system...
  44. ncbi Two novel xanthones from Garcinia mangostana
    G Gopalakrishnan
    Centre for Natural Products SPIC Science Foundation 111, Mount Road, Chennai 600 032, India
    Fitoterapia 71:607-9. 2000
    The isolation of two novel xanthones isolated from the fruit hulls of Garcinia mangostana is reported. The structures were elucidated by means of spectroscopic analysis.
  45. ncbi α-Glucosidase inhibition and antihyperglycemic activity of prenylated xanthones from Garcinia mangostana
    Hyung Won Ryu
    Division of Applied Life Science BK21 program, IALS, Gyeongsang National University, Jinju 660 701, Republic of Korea
    Phytochemistry 72:2148-54. 2011
    ..Furthermore, the most active α-glucosidase inhibitors (6, 9, and 14) were proven to be present in high quantities in the native seedcase by a HPLC chromatogram...
  46. ncbi Thai herbal formulas used for wound treatment: a study of their antibacterial potency, anti-inflammatory, antioxidant, and cytotoxicity effects
    Sasitorn Chusri
    Faculty of Traditional Thai Medicine, Prince of Songkla University, Hat Yai, Songkhla, Thailand
    J Altern Complement Med 19:671-6. 2013
    ..This present work was aimed to investigate wound healing-related biologic activities of traditional herbal formulas used for wound treatment in southern Thailand...
  47. ncbi Xanthones from mangosteen prevent lipopolysaccharide-mediated inflammation and insulin resistance in primary cultures of human adipocytes
    Akkarach Bumrungpert
    Department of Nutrition, Mahidol University, Bangkok 10400, Thailand
    J Nutr 139:1185-91. 2009
    ..Taken together, these data demonstrate that MG attenuates LPS-mediated inflammation and insulin resistance in human adipocytes, possibly by inhibiting the activation of MAPK, NF-kappaB, and AP-1...
  48. ncbi Two new xanthones from the pericarp of Garcinia mangostana
    Xiaojun Zhou
    a Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou, P R China
    Nat Prod Res 29:19-23. 2015
    ..G (2), were isolated from the EtOAc-soluble fraction of ethanolic extract from the pericarp of Garcinia mangostana. Their structures were established as 1,6,7-trihydroxy-5-(3-methylbut-2-enyl)-8-(3-hydroxy-3-methylbutyl)-6'..
  49. ncbi Anti-angiogenic effect of α-mangostin
    Tomoko Shiozaki
    Department of Pharmacognosy and Phytochemistry, Meiji Pharmaceutical University, Tokyo, Japan
    J Nat Med 67:202-6. 2013
    Eleven known prenyl xanthones, isolated from the pericarp of Garcinia mangostana, were tested for their ability to inhibit the phosphorylation of kinase domain receptor (KDR) tyrosine kinase...
  50. pmc α-Mangostin extracted from the pericarp of the mangosteen (Garcinia mangostana Linn) reduces tumor growth and lymph node metastasis in an immunocompetent xenograft model of metastatic mammary cancer carrying a p53 mutation
    Masa Aki Shibata
    Laboratory of Anatomy and Histopathology, Faculty of Health Science, Osaka Health Science University, Osaka, Japan
    BMC Med 9:69. 2011
    ....
  51. ncbi Microbial metabolism of α-mangostin isolated from Garcinia mangostana L
    Panarat Arunrattiyakorn
    Department of Chemistry, Faculty of Science, Srinakharinwirot University, Bangkok, Thailand
    Phytochemistry 72:730-4. 2011
    Mangostin (1), a prenylated xanthone isolated from the fruit hull of Garcinia mangostana L., was individually metabolized by two fungi, Colletotrichum gloeosporioides (EYL131) and Neosartorya spathulata (EYR042), repectively...
  52. ncbi α-Mangostin induces apoptosis in human chondrosarcoma cells through downregulation of ERK/JNK and Akt signaling pathway
    Aungkana Krajarng
    Department of Biochemistry, Faculty of Medicine, Srinakharinwirot University, Bangkok, Thailand
    J Agric Food Chem 59:5746-54. 2011
    ..Mangostin, a component of Garcinia mangostana Linn, is a xanthone derivative shown to have antioxidant and antitumor properties...
  53. ncbi A concise and efficient total synthesis of α-mangostin and β-mangostin from Garcinia mangostana
    Dandan Xu
    Jiang Su Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, China
    Nat Prod Commun 8:1101-3. 2013
    ..Meanwhile the first total synthesis of beta-mangostin is presented with a similar approach...
  54. ncbi γ-Mangostin from Garcinia mangostana pericarps as a dual agonist that activates Both PPARα and PPARδ
    Nobuyasu Matsuura
    Department of Life Science, Faculty of Science, Okayama University of Science
    Biosci Biotechnol Biochem 77:2430-5. 2013
    We tested the peroxisome proliferator-activated receptor (PPAR)δ agonistic activity of a Garcinia mangostana pericarp extract to develop a treatment for the metabolic syndrome, and demonstrated γ-mangostin to be an active compound on ..
  55. ncbi Cytotoxic prenylated xanthones from the pericarps of Garcinia mangostana
    Zeng Xu
    School of Chemistry and Chemical Engineering, Sun Yat Sen University, Guangzhou 510275, China
    Molecules 19:1820-7. 2014
    Bioassay-guided fractionation of an ethanol extract of the pericarps of Garcinia mangostana led to the isolation of two new prenylated xanthones, named 1,3,7-trihydroxy-2-(3-methyl-2-butenyl)-8-(3-hydroxy-3-methylbutyl)-xanthone (1) and ..
  56. ncbi Prenylated xanthones from mangosteen as promising cholinesterase inhibitors and their molecular docking studies
    K Y Khaw
    Discipline of Pharmacology, School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800 Penang, Malaysia
    Phytomedicine 21:1303-9. 2014
    b>Garcinia mangostana is a well-known tropical plant found mostly in South East Asia. The present study investigated acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activities of G...
  57. ncbi A new xanthone from the pericarp of Garcinia mangostana
    Manqin Fu
    Guangdong Open Access Laboratory ofAgri food Processing, Sericulture and Agri Food Research Institute, Guangdong Academy of Agicultural Sciences, Guangzhou 510610, P R China
    Nat Prod Commun 8:1733-4. 2013
    ..1), was isolated from the EtOAc-soluble partition of the ethanol extract of the pericarp of Garcinia mangostana L., along with three known compounds, namely 8-deoxygartanin (2), 1-isomangostin (3), and garcinone C (4)...
  58. ncbi Neuroprotective effects of xanthone derivative of Garcinia mangostana against lead-induced acetylcholinesterase dysfunction and cognitive impairment
    Moe Pwint Phyu
    Biomedical Sciences, School of Allied Health Sciences and Public Health, Walailak University, Nakhon Si Thammarat 80160, Thailand
    Food Chem Toxicol 70:151-6. 2014
    ..This study was designed to investigate the protective effect of a xanthone derivative of Garcinia mangostana against lead-induced acetycholinesterase (AChE) dysfunction and cognitive impairment in mice...
  59. ncbi Evaluation of antimicrobial and antitumoral activity of Garcinia mangostana L. (mangosteen) grown in Southeast Brazil
    Bruna Lais Almeida Cunha
    Department of Biological Sciences, Universidade Estadual de Santa Cruz, Ilheus, BA
    Acta Cir Bras 29:21-8. 2014
    To characterize the anatomy of the fruit and leaf and the presence of phytocompounds. To evaluate the antitumor and antimicrobial activity of ethanolic extract of Garcinia mangostana L. (mangosteen) cultivated in southeastern Brazil.
  60. ncbi Bioaccessibility, biotransformation, and transport of alpha-mangostin from Garcinia mangostana (Mangosteen) using simulated digestion and Caco-2 human intestinal cells
    Akkarach Bumrungpert
    Faculty of Medicine, Ramathibodi Hospital and Institute of Nutrition, Mahidol University, Salaya, Thailand
    Mol Nutr Food Res 53:S54-61. 2009
    ..Transepithelial transport of alpha-mangostin was increased during prandial-like compared to fasted conditions suggesting that absorption is enhanced by dietary fat...
  61. ncbi Xanthones from the green fruit hulls of Garcinia mangostana
    Sunit Suksamrarn
    Department of Chemistry, Faculty of Science, Srinakharinwirot University, Bangkok 10110, Thailand
    J Nat Prod 65:761-3. 2002
    ..mangostenol (1), mangostenone A (2), and mangostenone B (3), were isolated from the green fruit hulls of Garcinia mangostana, along with the known xanthones, trapezifolixanthone, tovophyllin B (4), alpha- and beta-mangostins, ..
  62. ncbi Fruit pod extracts as a source of nutraceuticals and pharmaceuticals
    Azila Abdul Karim
    Cocoa Innovation and Technology Centre, Malaysian Cocoa Board, Nilai, Negeri Sembilan, Malaysia
    Molecules 17:11931-46. 2012
    ..In this review, information on fruit pods or pericarp of Garcinia mangostana, Ceratonia siliqua, Moringa oleifera, Acacia nilotica, Sapindus rarak and Prosopis cineraria is presented ..
  63. ncbi Rapid identification of cholinesterase inhibitors from the seedcases of mangosteen using an enzyme affinity assay
    Hyung Won Ryu
    Division of Applied Life Science BK21 plus, IALS, Gyeongsang National University, Jinju 660 701, Republic of Korea
    J Agric Food Chem 62:1338-43. 2014
    ..Consistent with the binding screen and fluorescence quenching, γ-mangostin 6 had a much higher affinity for AChE than 9-hydroxycalabaxanthone 9. This validates this screening protocol as a rapid method to identify inhibitors of AChE...
  64. ncbi Antibacterial activity of xanthones from Garcinia mangostana (L.) and their structure-activity relationship studies
    H R W Dharmaratne
    Natural Products Programme, Institute of Fundamental Studies, Kandy, Sri Lanka
    Nat Prod Res 27:938-41. 2013
    Antibacterial activities of prenylated xanthones from Garcinia mangostana and their synthetic analogues were investigated, and their structure-activity relationships have been studied...
  65. ncbi Biological activity and stability of mangosteen as a potential natural color
    Nattaya Lourith
    School of Cosmetic Science, Mae Fah Luang University, Chiang Rai, Thailand
    Biosci Biotechnol Biochem 75:2257-9. 2011
    ..0 mg/mL at pH 3 at 23 °C over 7 d. Mangosteen pericarp extracts can therefore be used in pharmaceutical products that require low to medium pH...
  66. pmc Xanthones in mangosteen juice are absorbed and partially conjugated by healthy adults
    Chureeporn Chitchumroonchokchai
    Department of Human Nutrition, The Ohio State University, Columbus, OH, USA
    J Nutr 142:675-80. 2012
    ..These results show that xanthones in mangosteen juice are absorbed when ingested along with a high-fat meal, although release of xanthones from pericarp particles during digestion may be limited...
  67. pmc Alterations in cell cycle and induction of apoptotic cell death in breast cancer cells treated with α-mangostin extracted from mangosteen pericarp
    Hitomi Kurose
    Division of Life Sciences, Department of Anatomy and Cell Biology, Osaka Medical College, Takatsuki, Osaka, Japan
    J Biomed Biotechnol 2012:672428. 2012
    ..In conclusion, α-mangostin may be useful as a therapeutic agent for breast cancer carrying a p53 mutation and having HER2- and hormone receptor-negative subtypes...
  68. ncbi Immunomodulatory activities of alpha-mangostin on peripheral blood mononuclear cells
    Pimolkan Kasemwattanaroj
    Department of Microbiology, Faculty of Pharmacy, Mahidol University, Bangkok 10400, Thailand
    Nat Prod Commun 8:1257-60. 2013
    Mangosteen (Garcinia mangostana L.) a tropical fruit, has been used in traditional medicine. A frequently used part of mangosteen is the pericarp, containing a high content of xanthones...
  69. ncbi Phytochemical, antimicrobial and antiprotozoal evaluation of Garcinia mangostana pericarp and α-mangostin, its major xanthone derivative
    Shaza M Al-Massarani
    Department of Pharmacognosy, College of Pharmacy, King Saud University, P O Box 2457, Riyadh 11451, Saudi Arabia
    Molecules 18:10599-608. 2013
    Five xanthone derivatives and one flavanol were isolated from the dichloromethane extract of Garcinia mangostana. Dichloromethane, ethyl acetate extract and the major xanthone (α-mangostin) were evaluated in vitro against erythrocytic ..
  70. ncbi Pharmacokinetic properties of pure xanthones in comparison to a mangosteen fruit extract in rats
    Li Li
    Department of Pharmaceutics, College of Pharmacy, University of Florida, Gainesville, FL, USA
    Planta Med 79:646-53. 2013
    The xanthones α-mangostin and γ-mangostin are the major bioactive compounds in Garcinia mangostana (mangosteen) fruit extracts. Previously, we reported the pharmacokinetic properties of α-mangostin in rats...
  71. ncbi Chemical genetic screen in fission yeast reveals roles for vacuolar acidification, mitochondrial fission, and cellular GMP levels in lifespan extension
    Jessica Stephan
    Zentrum für Medizinische Biotechnologie, Universitat Duisburg Essen, Essen, Germany
    Aging Cell 12:574-83. 2013
    ..Taken together, these results reveal unanticipated anti-aging activities for several phytochemicals and open up opportunities for the development of novel anti-aging therapies...
  72. ncbi [Optimize technique of extracting alpha-mangostin from pericarp of Garcinia mangostana by supersonic wave using central composite design-response surface methodology]
    Yan Zhao
    College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China
    Zhong Yao Cai 35:973-7. 2012
    To optimize the extraction technique for alpha-mangostin from pericarp of Garcinia Mangostana.
  73. pmc In vitro and in vivo anti-colon cancer effects of Garcinia mangostana xanthones extract
    Abdalrahim F A Aisha
    Department of Pharmacology, School of Pharmaceutical Sciences, Universiti Sains Malaysia, Minden, 11800, Pulau Penang, Malaysia
    BMC Complement Altern Med 12:104. 2012
    ..Xanthones are a group of oxygen-containing heterocyclic compounds with remarkable pharmacological effects such as anti-cancer, antioxidant, anti-inflammatory, and antimicrobial activities...
  74. ncbi Gamma-mangostin, a micronutrient of mangosteen fruit, induces apoptosis in human colon cancer cells
    Hui Fang Chang
    Department of Pharmacognosy, School of Pharmacy, College of Pharmacy, and Center of e CAM, Taipei Medical University, 250 Wusing St, Taipei 110, Taiwan
    Molecules 17:8010-21. 2012
    ..The treatment of colorectal cancer includes surgery, radiation therapy and chemotherapy. Mangosteen (Garcinia mangostana) is a famous Asian tropical fruit. γ-Mangostin is a xanthone derivative isolated from the fruit hull...
  75. ncbi Anti-skin cancer properties of phenolic-rich extract from the pericarp of mangosteen (Garcinia mangostana Linn.)
    Jing J Wang
    Level 4, Health Science Building, Department of Medical Biotechnology, Flinders Medical Sciences and Technology, School of Medicine, Faculty of Health Science, Flinders University, Registry Road, Bedford Park, Adelaide 5042, Australia
    Food Chem Toxicol 50:3004-13. 2012
    ..Apoptosis was significantly increased after MPEE treatment of SK-MEL-28 cells. Hence, MPEE showed strong anti-skin cancer effect on these two skin cancer cell lines, with potential as an anti-skin cancer agent...
  76. ncbi In vivo toxicity and antitumor activity of mangosteen extract
    Nuttavut Kosem
    Innovation Center for Medical Redox Navigation, Kyushu University, Fukuoka, 812 8582, Japan
    J Nat Med 67:255-63. 2013
    Mangosteen (Garcinia mangostana) has been widely used in the traditional medicine of Thailand to treat various ailments, especially diseases of the digestive system and infections...
  77. ncbi Antibacterial activity of extracts from five medicinal plants and their formula against bacteria that cause chronic wound infection
    Pornthep Temrangsee
    Faculty of Medicine, Thammasat University, Pathumthani, Thailand
    J Med Assoc Thai 94:S166-71. 2011
    ..Antibacterial activity of several herbal plants has been reported. Thai medicinal plants which possess biological activities are potential to develop an alternative treatment of bacterial infection...
  78. ncbi Antitumour and free radical scavenging effects of γ-mangostin isolated from Garcinia mangostana pericarps against hepatocellular carcinoma cell
    Hui Fang Chang
    Department of Pharmacognosy, School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei, Taiwan
    J Pharm Pharmacol 65:1419-28. 2013
    ..In this study, we wanted to select and develop some of novel effectual agents or phytochemicals of γ-mangostin for clinical management or prevent hepatocellular carcinoma cell (HCC)...
  79. ncbi gamma-Mangostin inhibits inhibitor-kappaB kinase activity and decreases lipopolysaccharide-induced cyclooxygenase-2 gene expression in C6 rat glioma cells
    Keigo Nakatani
    Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku University, Aoba, Aramaki, Aoba ku, Sendai 980 8578, Japan
    Mol Pharmacol 66:667-74. 2004
    We investigated the effect of gamma-mangostin purified from the fruit hull of the medicinal plant Garcinia mangostana on spontaneous prostaglandin E(2) (PGE(2)) genase release and inducible cyclooxy-2 (COX-2) gene expression in C6 rat ..
  80. ncbi Alpha-mangostin induces Ca2+-ATPase-dependent apoptosis via mitochondrial pathway in PC12 cells
    Ayumi Sato
    Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan
    J Pharmacol Sci 95:33-40. 2004
    ..Among these compounds, alpha-mangostin, from the fruit hull of Garcinia mangostana L., had the most potent effect with the EC(50) value of 4 microM...
  81. ncbi Evaluating the efficacy in improving facial photodamage with a mixture of topical antioxidants
    Jessica Hsu
    University of California, San Diego, USA
    J Drugs Dermatol 6:1141-8. 2007
    ..9 mm3. The addition of 3 antioxidants, green and white teas, mangosteen, and pomegranate, have an additive effect to enhance the improvement of age-related changes in the skin...
  82. ncbi Prenylated xanthones as potential antiplasmodial substances
    Wilawan Mahabusarakam
    Department of Chemistry, Prince of Songkla University, Hat Yai, Songkhla, Thailand
    Planta Med 72:912-6. 2006
    Mangostin, the major xanthone of Garcinia mangostana, and a series of synthetic derivatives were investigated for their in vitro antiplasmodial activity against Plasmodium falciparum...
  83. ncbi Mangosteen for the cancer patient: facts and myths
    Simon Yeung
    Memorial Sloan Kettering Cancer Center, New York, NY, USA
    J Soc Integr Oncol 4:130-4. 2006
    ..Cancer patients should use caution before consuming mangosteen products as they can potentially interact with cancer treatments and also affect blood sugar levels...
  84. ncbi Comparison of bioactive compounds content, free radical scavenging and anti-acne inducing bacteria activities of extracts from the mangosteen fruit rind at two stages of maturity
    Werayut Pothitirat
    Department of Pharmacognosy, Faculty of Pharmacy, Mahidol University, Bangkok, Thailand
    Fitoterapia 80:442-7. 2009
    ..Thus, the young and mature stages of mangosteen fruit rind should be beneficial for further development of antioxidant and anti-acne pharmaceutical preparations, respectively...
  85. ncbi In vitro inhibition of multiple cytochrome P450 isoforms by xanthone derivatives from mangosteen extract
    Robert S Foti
    Amgen, Inc, Pharmacokinetics and Drug Metabolism, 1201 Amgen Court West, Mail Stop AW2 D2751, Seattle, WA 98119, USA
    Drug Metab Dispos 37:1848-55. 2009
    ..Finally, in vivo plasma concentrations of alpha-mangostin, the most abundant xanthone derivative found in mangosteen, were predicted using Simcyp and found to be well above their respective in vitro K(i) values for CYP2C8 and CYP2C9...
  86. ncbi Cytotoxic prenylated xanthones from the young fruit of Garcinia mangostana
    Sunit Suksamrarn
    Department of Chemistry, Faculty of Science, Srinakharinwirot University, Sukhumvit, Bangkok, Thailand
    Chem Pharm Bull (Tokyo) 54:301-5. 2006
    ..E (3), together with 16 known xanthones 4-19, were isolated from the young fruit (7-week maturity stage) of Garcinia mangostana. The structural elucidation of the new compounds was mainly established on the basis of 1D and 2D NMR and ..
  87. ncbi Antimicrobial effects of Thai medicinal plants against acne-inducing bacteria
    Mullika Traidej Chomnawang
    Department of Microbiology, Faculty of Pharmacy, Mahidol University, 447 Sri Ayudthaya Road, Rachathevi, Bangkok 10400, Thailand
    J Ethnopharmacol 101:330-3. 2005
    ..Among those, Senna alata, Eupatorium odoratum, Garcinia mangostana, and Barleria lupulina had strong inhibitory effects...
  88. ncbi A geranylated biphenyl derivative from Garcinia malvgostana
    H R W Dharmaratne
    Natural Products Programme, Institute of Fundamental Studies, Kandy 20000, Sri Lanka
    Nat Prod Res 19:239-43. 2005
    Extracts of root bark, stem bark and the latex collected from the green fruits of Garcinia mangostana gave alpha-mangostin, beta-mangostin, gamma-mangostin, garcinone-E, methoxy-beta-mangostin and a new geranylated biphenyl derivative 3-..
  89. ncbi Validation of LC for the determination of alpha-mangostin in mangosteen peel extract: a tool for quality assessment of Garcinia mangostana L
    Sukit Yodhnu
    Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat Yai, Songkhla 90110, Thailand
    J Chromatogr Sci 47:185-9. 2009
    Mangosteen, Garcinia mangostana L., is known as the "Queen of fruits" and can be cultivated in the tropical rainforest such as Malaysia, Indonesia, and Thailand...
  90. ncbi Alpha-mangostin suppresses PC-3 human prostate carcinoma cell metastasis by inhibiting matrix metalloproteinase-2/9 and urokinase-plasminogen expression through the JNK signaling pathway
    Shun Hsing Hung
    Division of Urology, Department of Surgery, Chi Mei Medical Center, No 901, Jhong Hua Road, Yong Kang, Tainan 710, Taiwan, Republic of China
    J Agric Food Chem 57:1291-8. 2009
    Alpha-mangostin, a component of Garcinia mangostana Linn, is a xanthone derivative shown to have antioxidant and anticarcinogen properties...
  91. ncbi Effects of herbal mouthwash containing the pericarp extract of Garcinia mangostana L on halitosis, plaque and papillary bleeding index
    Supanee Rassameemasmaung
    Department of Oral Medicine, Faculty of Dentistry, Mahidol University, Bangkok, Thailand
    J Int Acad Periodontol 9:19-25. 2007
    ....
  92. ncbi Effects of alpha-mangostin from mangosteen pericarp extract and imidacloprid on Nilaparvata lugens (Stal.) and non-target organisms: toxicity and detoxification mechanism
    Vasakorn Bullangpoti
    Dept of Zoology, Faculty of Science, Kasetsart University, Bangkok 10900, Thailand
    Commun Agric Appl Biol Sci 72:431-41. 2007
    ....
  93. ncbi Electrospun poly(vinyl alcohol) fiber mats as carriers for extracts from the fruit hull of mangosteen
    Praneet Opanasopit
    Faculty of Pharmacy, Silpakorn University, Thailand
    J Cosmet Sci 59:233-42. 2008
    ..5%, 5%, and 10% w/w of the extract at 120 min were 73.2%, 83.6%, and 81.3% w/w, respectively. However, much slower release from the cast films was observed (i.e., 4.3%, 29.1%, and 40.8% w/w, respectively)...
  94. ncbi Assay-guided fractionation study of alpha-amylase inhibitors from Garcinia mangostana pericarp
    Alvin Eng Kiat Loo
    Department of Chemistry, National University of Singapore, Republic of Singapore
    J Agric Food Chem 55:9805-10. 2007
    Alpha-amylase inhibitor (alpha-AI) activity of Garcinia mangostana, commonly known as mangosteen, pericarp extracts was studied by assay guided fractionations from lipophilic to hydrophilic using combined solvent extraction and Amberlite ..
  95. ncbi Oligomeric proanthocyanidins from mangosteen pericarps
    Caili Fu
    Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543, Republic of Singapore
    J Agric Food Chem 55:7689-94. 2007
    ..The isolated proanthocyanidins are potent peroxyl radical scavengers as evidenced by the high oxygen radical scavenging capacity at 1.7 x 10 (4) micromol TE/g, much higher than that of pine bark and grape seed extracts...
  96. ncbi Thin-layer chromatography-densitometric analysis of alpha-mangostin content in Garcinia mangostana fruit rind extracts
    Werayut Pothitirat
    Mahidol University, Department of Pharmacognosy, Faculty of Pharmacy, 447 Sri Ayudhaya Rd, Ratchatewi, Bangkok, Thailand
    J AOAC Int 91:1145-8. 2008
    The fruit rinds of mangosteen (Garcinia mangostana Linn.) have long been used as traditional medicines for treatment of skin infections, wounds, and diarrhea...
  97. ncbi HPLC analysis of selected xanthones in mangosteen fruit
    Edward B Walker
    Department of Chemistry, Weber State University, Ogden, Utah 84403 2503, USA
    J Sep Sci 30:1229-34. 2007
    ..This analytical method is applied to the analysis of these xanthones in the rind of the mangosteen fruit, Garcinia mangostana.
  98. ncbi Characterized mechanism of alpha-mangostin-induced cell death: caspase-independent apoptosis with release of endonuclease-G from mitochondria and increased miR-143 expression in human colorectal cancer DLD-1 cells
    Yoshihito Nakagawa
    Gifu International Institute of Biotechnology, 1 1 Naka fudogaoka, Kakamigahara, Gifu 504 0838, Japan
    Bioorg Med Chem 15:5620-8. 2007
    alpha-Mangostin, a xanthone from the pericarps of mangosteen (Garcinia mangostana Linn.), was evaluated for in vitro cytotoxicity against human colon cancer DLD-1 cells...
  99. ncbi Antibacterial activity of Thai medicinal plants against methicillin-resistant Staphylococcus aureus
    Mullika Traidej Chomnawang
    Department of Microbiology, Faculty of Pharmacy, Mahidol University, Bangkok, Thailand
    Fitoterapia 80:102-4. 2009
    ..Seventeen Thai medicinal plants were investigated for their activity against MRSA. Garcinia mangostana was identified as the most potent plant, and its activity was traced to the prenylated xanthone, alpha-..
  100. ncbi Centrifugal partition chromatography directly interfaced with mass spectrometry for the fast screening and fractionation of major xanthones in Garcina mangostana
    E Destandau
    ICOA, Universite d Orleans, UMR CNRS 6005, 45067 Orleans Cedex 2, France
    J Chromatogr A 1216:1390-4. 2009
    ..The dual mode or elution-extrusion which are less solvent-consuming and faster than the elution mode were used without loss of ionisation and detection...
  101. ncbi Mitigation of mitochondrial dysfunction and regulation of eNOS expression during experimental myocardial necrosis by alpha-mangostin, a xanthonic derivative from Garcinia mangostana
    Pandima Devi Sampath
    Center for Advanced Studies in Botany, University of Madras, Chennai, India
    Drug Chem Toxicol 32:344-52. 2009
    ....

Research Grants3

  1. Mangostin: A Dietary-Based Xanthone For Prostate Cancer Chemoprevention
    Jeremy James Johnson; Fiscal Year: 2010
    ..agent, alpha-Mangostin, a non- nutrient and non-toxic natural agent present in the Mangosteen fruit (Garcinia mangostana)...
  2. OBESE FEMALE RESTRAINED EATERS : TWO TREATMENT OPTIONS
    Judith Stern; Fiscal Year: 2002
    ..A manual of procedures will be generated to assist others in replicating the intervention. ..
  3. Magnesium and Asthma - Clinical Trials
    Judith Stern; Fiscal Year: 2004
    ..We do not anticipate that Mg supplementation will replace conventional treatment, but may complement and decrease the need for conventional medications. ..