garcinia kola

Summary

Summary: A plant species of the family CLUSIACEAE. The common name of 'Bitter Kola' is sometimes also used to refer to COLA.

Top Publications

  1. ncbi Curcumin and kolaviron ameliorate di-n-butylphthalate-induced testicular damage in rats
    Ebenezer Olatunde Farombi
    Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry College of Medicine, University of Ibadan, Ibadan, Nigeria
    Basic Clin Pharmacol Toxicol 100:43-8. 2007
  2. ncbi Antibacterial effect of Zingiber officinale and Garcinia kola on respiratory tract pathogens
    J F T K Akoachere
    Department of Life Sciences, Faculty of Science, University of Buea, PO Box 63, Cameroon
    East Afr Med J 79:588-92. 2002
  3. doi Effect of kolaviron, a biflavonoid complex from Garcinia kola seeds, on ethanol-induced oxidative stress in liver of adult wistar rats
    O A Adaramoye
    Department of Biochemistry, University of Ibadan, Nigeria
    J Med Food 12:584-90. 2009
  4. doi Biocidal activity of partially purified fractions from methanolic extract of Garcinia kola (Heckel) seeds on bacterial isolates
    D A Akinpelu
    Applied and Environmental Microbiology Research Group, Department of Biochemistry and Microbiology, University of Fort Hare, Alice, South Africa
    Biol Res 41:277-87. 2008
  5. ncbi Toxicity and mutagenic activity of some selected Nigerian plants
    A A Sowemimo
    Department of Pharmacognosy, Obafemi Awolowo University, Ile Ife, Nigeria
    J Ethnopharmacol 113:427-32. 2007
  6. doi Comparative study on the efficacy of Garcinia kola in reducing some heavy metal accumulation in liver of Wistar rats
    C R Nwokocha
    Department of Basic Medical Sciences, University of the West Indies, Mona Campus, Kingston 7, Jamaica
    J Ethnopharmacol 135:488-91. 2011
  7. ncbi Endothelium-independent vasodilation induced by kolaviron, a biflavonoid complex from Garcinia kola seeds, in rat superior mesenteric arteries
    Oluwatosin A Adaramoye
    Laboratorio de Tecnologia Farmaceutica, Universidade Federal da Paraiba, Joao Pessoa, Paraiba, Brazil
    J Smooth Muscle Res 45:39-53. 2009
  8. doi In vitro antioxidant and free radical scavenging activities of Garcinia kola seeds
    Tebekeme Okoko
    Biochemistry Division, Department of Chemical Sciences, Niger Delta University, Wilberforce Island, Bayelsa State, Nigeria
    Food Chem Toxicol 47:2620-3. 2009
  9. ncbi Hepatoprotection of D-galactosamine-induced toxicity in mice by purified fractions from Garcinia kola seeds
    Oluwatosin A Adaramoye
    Drug Metabolism and Toxicology Unit, Department of Biochemistry, University of Ibadan, Nigeria
    Basic Clin Pharmacol Toxicol 98:135-41. 2006
  10. ncbi Protective effect of kolaviron, a biflavonoid from Garcinia kola seeds, in brain of Wistar albino rats exposed to gamma-radiation
    Oluwatosin Adekunle Adaramoye
    Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine, Faculty of Basic Medical Sciences, University of Ibadan, Ibadan 20005, Nigeria
    Biol Pharm Bull 33:260-6. 2010

Scientific Experts

  • E O Farombi
  • Chukwuemeka S Nworu
  • Oluwatosin Adekunle Adaramoye
  • Anthony I Okoh
  • Tebekeme Okoko
  • Musa T Yakubu
  • S B Olaleye
  • O O Oguntibeju
  • Collise Njume
  • C R Nwokocha
  • E Etebu
  • Oyeronke A Odunola
  • Marc Birringer
  • Dambudzo Penduka
  • I A Adedara
  • Sunny O Abarikwu
  • V B Braide
  • Christopher Okunji
  • Omolola R Ayepola
  • Isaac A Adedara
  • Olumayowa O Igado
  • Mina T Ibulubo
  • Christinah T Seanego
  • Stephen T Lacmata
  • Aditya B Pant
  • Sunday A Ajayi
  • Samuel A Onasanwo
  • Dibua Esther Uju
  • Bassey S Antia
  • Omonike O Ogbole
  • O E Adeleke
  • Adebukunola O Adefule-Ositelu
  • P M Udia
  • P O Agada
  • Joseph Gangoue-Pieboji
  • A A Ahumibe
  • Maurice Iwu
  • Francesco Mazzini
  • A O Adefule-Ositelu
  • Eo Ajani
  • D A Akinpelu
  • R N Okigbo
  • O C Afolabi
  • E I Adeyeye
  • A A Sowemimo
  • Quan Bin Han
  • G C Onunkwo
  • L Tona
  • Charles O Esimone
  • J F T K Akoachere
  • Kenji Terashima
  • Chris O Okunji
  • Novel N Chegou
  • S Vaithinathan
  • R Jubendradass
  • Premendu P Mathur
  • Nicole L Brooks
  • P P Mathur
  • Roland N Ndip
  • Gerald I Eze
  • Doroteo Baxter-Grillo
  • Oluwasanmi O Aina
  • Gerald Ngo Teke
  • Simplice B Tankeo
  • James O Olopade
  • Victor Kuete
  • Jean Marie Pages
  • Adebukola Adesida
  • Jules R Kuiate
  • Raymond I Ozolua
  • Dickson O Uwaya
  • Jean P Dzoyem
  • Gideon B Ojo
  • Gautam Palit
  • Neetu Singh
  • Mahendra P Kashyap
  • David A Ofusori
  • Oladele A Ayoka
  • Omobola O Okoh
  • Nnamani Petra Obioma
  • Taiwo A Abayomi
  • Adekilekun A Tijani
  • Bernice O Adegbehingbe
  • Acharavadee Pansanit
  • Edith O Ajaiyeoba
  • Kehinde Oladigbolu
  • Prasat Kittakoop
  • M E Coker
  • Adebayo K Adefule
  • Okon D Ekpa

Detail Information

Publications72

  1. ncbi Curcumin and kolaviron ameliorate di-n-butylphthalate-induced testicular damage in rats
    Ebenezer Olatunde Farombi
    Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry College of Medicine, University of Ibadan, Ibadan, Nigeria
    Basic Clin Pharmacol Toxicol 100:43-8. 2007
    ..study was carried out to evaluate the ameliorative effects of kolaviron (a biflavonoid from the seeds of Garcinia kola) and curcumin (from the rhizome, Curcuma longa L...
  2. ncbi Antibacterial effect of Zingiber officinale and Garcinia kola on respiratory tract pathogens
    J F T K Akoachere
    Department of Life Sciences, Faculty of Science, University of Buea, PO Box 63, Cameroon
    East Afr Med J 79:588-92. 2002
    To investigate the antibacterial activity of Zingiber officinale (ginger) Garcinia kola (bitter kola) on four respiratory tract pathogens.
  3. doi Effect of kolaviron, a biflavonoid complex from Garcinia kola seeds, on ethanol-induced oxidative stress in liver of adult wistar rats
    O A Adaramoye
    Department of Biochemistry, University of Ibadan, Nigeria
    J Med Food 12:584-90. 2009
    ..Kolaviron (KV), a biflavonoid complex from Garcinia kola seeds, possesses a variety of biological activities, including antioxidant...
  4. doi Biocidal activity of partially purified fractions from methanolic extract of Garcinia kola (Heckel) seeds on bacterial isolates
    D A Akinpelu
    Applied and Environmental Microbiology Research Group, Department of Biochemistry and Microbiology, University of Fort Hare, Alice, South Africa
    Biol Res 41:277-87. 2008
    The in vitro antibacterial activity of crude methanolic extract of the seeds of Garcinia kola was investigated. The extracts exhibited antibacterial activities with zones of inhibition ranging from 10 mm to 25 mm...
  5. ncbi Toxicity and mutagenic activity of some selected Nigerian plants
    A A Sowemimo
    Department of Pharmacognosy, Obafemi Awolowo University, Ile Ife, Nigeria
    J Ethnopharmacol 113:427-32. 2007
    ..Morinda lucida root bark, Nymphaea lotus whole plant and Garcinia kola root were active in the three test systems...
  6. doi Comparative study on the efficacy of Garcinia kola in reducing some heavy metal accumulation in liver of Wistar rats
    C R Nwokocha
    Department of Basic Medical Sciences, University of the West Indies, Mona Campus, Kingston 7, Jamaica
    J Ethnopharmacol 135:488-91. 2011
    b>Garcinia kola is regarded as an antidote and anti-hepatotoxic agent. We examined its protection ability against mercury (Hg), lead (Pb) and cadmium (Cd) accumulation in the liver...
  7. ncbi Endothelium-independent vasodilation induced by kolaviron, a biflavonoid complex from Garcinia kola seeds, in rat superior mesenteric arteries
    Oluwatosin A Adaramoye
    Laboratorio de Tecnologia Farmaceutica, Universidade Federal da Paraiba, Joao Pessoa, Paraiba, Brazil
    J Smooth Muscle Res 45:39-53. 2009
    ..gastroprotective, hypolipidemic and hypoglycemic effects of kolaviron (KV), a biflavonoid complex from Garcinia kola seeds...
  8. doi In vitro antioxidant and free radical scavenging activities of Garcinia kola seeds
    Tebekeme Okoko
    Biochemistry Division, Department of Chemical Sciences, Niger Delta University, Wilberforce Island, Bayelsa State, Nigeria
    Food Chem Toxicol 47:2620-3. 2009
    b>Garcinia kola Heckel--a tropical plant which grows in moist forest, has found wide applications in traditional medicine especially in the West and Central African sub-region...
  9. ncbi Hepatoprotection of D-galactosamine-induced toxicity in mice by purified fractions from Garcinia kola seeds
    Oluwatosin A Adaramoye
    Drug Metabolism and Toxicology Unit, Department of Biochemistry, University of Ibadan, Nigeria
    Basic Clin Pharmacol Toxicol 98:135-41. 2006
    The hepatoprotective effect of a biflavonoid complex, kolaviron, and its fractions from Garcinia kola seeds, together with the possible mechanisms involved was investigated in mice intoxicated with a single dose of D-galactosamine (GalNH(..
  10. ncbi Protective effect of kolaviron, a biflavonoid from Garcinia kola seeds, in brain of Wistar albino rats exposed to gamma-radiation
    Oluwatosin Adekunle Adaramoye
    Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine, Faculty of Basic Medical Sciences, University of Ibadan, Ibadan 20005, Nigeria
    Biol Pharm Bull 33:260-6. 2010
    This study was designed to evaluate the protective effect of kolaviron (KV), a biflavonoid from Garcinia kola seeds, against gamma-radiation (5 Gy)-induced oxidative stress in brain of Wistar rats...
  11. ncbi Antispasmodic and spasmolytic effects of methanolic extract from seeds of Garcinia kola on isolated rat small intestine
    P M Udia
    Department of Pharmacology, College of Medical Sciences, University of Calabar, Calabar, Nigeria
    Niger J Physiol Sci 24:111-6. 2009
    The antispasmodic and spasmolytic effects of methanolic extract of seeds of Garcinia kola Heckel were studied on smooth muscle preparations in vitro...
  12. ncbi Capillary electrophoresis determination of biflavanones from Garcinia kola in three traditional African medicinal formulations
    Chris O Okunji
    International Centre for Ethnomedicine and Drug Development, Nsukka Nigeria
    Planta Med 68:440-4. 2002
    ..active biflavanones present in three different traditional African medicinal preparations from the seeds of Garcinia kola was developed...
  13. ncbi Attenuation of indomethacin- and HCl/ethanol-induced oxidative gastric mucosa damage in rats by kolaviron, a natural biflavonoid of Garcinia kola seed
    S B Olaleye
    Department of Physiology, College of Medicine, University of Ibadan, Nigeria
    Phytother Res 20:14-20. 2006
    ..This study investigated the protective effects of kolaviron, a natural antioxidant from the seed of Garcinia kola, on oxidative gastric mucosal damage induced by HCl/ethanol, and indomethacin.A HCl/ethanol mixture (1...
  14. ncbi In vivo evaluation of interaction between aqueous seed extract of Garcinia kola Heckel and ciprofloxacin hydrochloride
    Charles O Esimone
    Department of Pharmaceutics, University of Nigeria, Nsukka, Enugu State, Nigeria
    Am J Ther 9:275-80. 2002
    The effect of Garcinia kola seed extract (100 mg/kg) on the pharmacokinetic and antibacterial effects of ciprofloxacin hydrochloride (40 mg/kg) was studied...
  15. ncbi Preparative isolation and identification of tyrosinase inhibitors from the seeds of Garcinia kola by high-speed counter-current chromatography
    Christopher Okunji
    Biotech Center, Cook College, Rutgers University, 59 Dudley Road, New Brunswick, NJ 08901 8520, USA
    J Chromatogr A 1151:45-50. 2007
    ..14.18.1), the rate-limiting enzyme in melanin synthesis. Four extracts including the methanol extract of Garcinia kola seeds at 100 microg/ml displayed >60% inhibition of tyrosinase activity...
  16. ncbi Some physical properties of tabletted seed of Garcinia kola (HECKEL)
    G C Onunkwo
    Department of Pharmaceutical Technology and Industrial Pharmacy, University of Nigeria, Nsukka, Nigeria
    Chem Pharm Bull (Tokyo) 52:649-53. 2004
    The formulation of Garcinia kola seeds into tablet dosage form and evaluation of some physical properties of the tablets are presented...
  17. ncbi Complete NMR assignments of the antibacterial biflavonoid GB1 from Garcinia kola
    Quan Bin Han
    Chinese Medicine Laboratory, Hong Kong Jockey Club Institute of Chinese Medicine, Hong Kong, PR China
    Chem Pharm Bull (Tokyo) 53:1034-6. 2005
    From the antibacterial fraction of the roots of Garcinia kola, 3'',4',4''',5,5'',7,7''-heptahydroxy-3,8''-biflavanone (GB1) was isolated as the major constituent, whose interesting conformations were studied on the basis of its 1D and 2D ..
  18. pmc Sub-acute effect of N(G)-nitro-l-arginine methyl-ester (L-NAME) on biochemical indices in rats: Protective effects of Kolaviron and extract of Curcuma longa L
    Oluwatosin A Adaramoye
    Department of Biochemistry, Drug Metabolism and Toxicology Research Laboratories, College of Medicine, University of Ibadan, Ibadan, Nigeria
    Pharmacognosy Res 4:127-33. 2012
    Kolaviron (KV) (biflavonoid from Garcinia kola) and extract of Curcuma longa (CL) are frequently used in folk medicine for treatment of hypertension. One of their mechanisms of action is to enhance antioxidant properties in animals...
  19. pmc Antibacterial Activities of Selected Cameroonian Plants and Their Synergistic Effects with Antibiotics against Bacteria Expressing MDR Phenotypes
    Stephen T Lacmata
    Department of Biochemistry, Faculty of Science, University of Dschang, Dschang, Cameroon
    Evid Based Complement Alternat Med 2012:623723. 2012
    ..extracts Garcinia lucida with the minimal inhibitory concentrations (MIC) varying from 128 to 512 μg/mL, Garcinia kola (MIC of 256 to 1024 μg/mL), and Picralima nitida (MIC of 128 to 1024 μg/mL) were active on all the ..
  20. doi Identification and antibacterial evaluation of bioactive compounds from Garcinia kola (Heckel) seeds
    Christinah T Seanego
    Department of Biochemistry and Microbiology, Faculty of Science and Agriculture, University of Fort Hare, Private Bag X 1314, Alice 5700, South Africa
    Molecules 17:6569-84. 2012
    ..The results obtained from this study justify the use of this plant in traditional medicine and provide leads which could be further exploited for the development of new and potent antimicrobials...
  21. pmc In vitro antilisterial properties of crude methanol extracts of Garcinia kola (Heckel) seeds
    Dambudzo Penduka
    Applied and Environmental Microbiology Research Group, Department of Biochemistry and Microbiology, University of Fort Hare, Alice 5700, South Africa
    ScientificWorldJournal 2012:694828. 2012
    Crude methanol extracts of Garcinia kola (Heckel) seeds were screened for their antilisterial activities against 42 Listeria bacteria isolated from wastewater effluents...
  22. pmc Evaluation of the protective and ameliorative properties of Garcinia kola on histamine-induced bronchoconstriction in guinea pigs
    Mina T Ibulubo
    Department of Anatomy, School of Basic Medical Sciences, University of Benin, Benin City, Nigeria
    Pharmacognosy Res 4:203-7. 2012
    b>Garcinia kola is popularly used in African traditional medicine for the relief of acute bronchoconstrictive episodes.
  23. doi Kolaviron prevents ethylene glycol monoethyl ether-induced testicular apoptosis via down-regulation of stress proteins, Fas/Fas-L and caspases expressions in rats
    Isaac A Adedara
    Department of Biochemistry and Molecular Biology, School of Life Sciences, Pondicherry University, Pondicherry, India and
    Toxicol Mech Methods 23:689-96. 2013
    ..investigated the protective role of kolaviron, a natural antioxidant biflavonoid isolated from the seed of Garcinia kola, in ethylene glycol monoethyl ether (EGEE)-induced testicular dysfunction in male rats...
  24. doi Kolaviron biflavanoids of Garcinia kola seeds protect atrazine-induced cytotoxicity in primary cultures of rat Leydig cells
    Sunny O Abarikwu
    Department of Chemical Sciences, College of Natural Sciences, Redeemer s University, Redemption City, Ogun State, Nigeria
    Int J Toxicol 31:407-15. 2012
    ..Taken together, these findings indicate that Kol protects ILCs from ATZ-induced toxicity via the reduction in ROS and MDA levels and induce normalization of mRNA levels of all the tested genes...
  25. ncbi In vitro antiplasmodial activity of extracts and fractions from seven medicinal plants used in the Democratic Republic of Congo
    L Tona
    Faculty of Pharmacy, University of Kinshasa, Democratic Republic of the Congo
    J Ethnopharmacol 93:27-32. 2004
    ..EtOH extracts (IC50 < 3 microg/ml) were those from Cassia occidentalis leaves, Euphorbia hirta whole plant, Garcinia kola stem bark and Phyllanthus niruri whole plant...
  26. pmc Antidiabetic effect of kolaviron, a biflavonoid complex isolated from Garcinia kola seeds, in Wistar rats
    O A Adaramoye
    Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, Faculty of Basic Medical Sciences, University of Ibadan, Ibadan, Nigeria
    Afr Health Sci 12:498-506. 2012
    Hypoglycaemic effect of kolaviron (KV), (biflavonoid from Garcinia kola) in streptozotocin (STZ)-diabetic rats has been established.
  27. doi Some bioactive potentials of two biflavanols isolated from Garcinia kola on cadmium-induced alterations of raw U937 cells and U937-derived macrophages
    Tebekeme Okoko
    Biochemistry Programme, Department of Chemical Sciences, Niger Delta University, PMB 71, Wilberforce Island, Bayelsa State, Nigeria
    Asian Pac J Trop Med 6:43-8. 2013
    To investigate the abilities of two flavonoids - Garcinia biflavanol-1 (GB-1) and Garcinia biflavanol-2 (GB-2) from Garcinia kola (G. kola) in reducing cadmium-induced effects on raw U937 cells and U937-derived macrophages.
  28. pmc In Vitro Anti-Listerial Activities of Crude n-Hexane and Aqueous Extracts of Garcinia kola (heckel) Seeds
    Dambudzo Penduka
    Applied and Environmental Microbiology Research Group AEMREG, Department of Biochemistry and Microbiology, University of Fort Hare, Alice, South Africa E mail
    Int J Mol Sci 12:6952-65. 2011
    We assessed the anti-Listerial activities of crude n-hexane and aqueous extracts of Garcinia kola seeds against a panel of 42 Listeria isolates previously isolated from wastewater effluents in the Eastern Cape Province of South Africa ..
  29. doi Chemoprotection of ethylene glycol monoethyl ether-induced reproductive toxicity in male rats by kolaviron, isolated biflavonoid from Garcinia kola seed
    I A Adedara
    Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria
    Hum Exp Toxicol 31:506-17. 2012
    The present study investigated the protective effect of kolaviron, a biflavonoid from the seed of Garcinia kola, on ethylene glycol monoethyl ether (EGEE)-induced reproductive toxicity in male rats...
  30. ncbi Commonly consumed and naturally occurring dietary substances affect biomarkers of oxidative stress and DNA damage in healthy rats
    E O Farombi
    Danish Institute for Food and Veterinary Research, Mørkhøj Bygade 19, DK 2860 Søborg, Denmark
    Food Chem Toxicol 42:1315-22. 2004
    ..The influence of black currant juice, Bowman-Birk protease inhibitor (BBI), kolaviron (a biflavonoid fraction of Garcinia kola seed), sugars, vitamin C and tert-butyl hydroperoxide on a wide range of biomarkers for oxidative stress, DNA ..
  31. doi Morphological and biochemical investigation into the possible neuroprotective effects of kolaviron (Garcinia kola bioflavonoid) on the brains of rats exposed to vanadium
    Olumayowa O Igado
    Department of Veterinary Anatomy, University of Ibadan, Ibadan, Nigeria
    Drug Chem Toxicol 35:371-80. 2012
    ..of the rat brain to vanadium, in the form of sodium metavanadate, and the comparative ameliorative effect of Garcinia kola and kolaviron (G. kola extract), was examined...
  32. doi Protective effects of kolaviron and quercetin on cadmium-induced testicular damage and endocrine pathology in rats
    E O Farombi
    Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria
    Andrologia 44:273-84. 2012
    This study evaluated the effects of kolaviron, a biflavonoid from Garcinia kola seed, and quercetin on cadmium-induced reproductive toxicity in rats...
  33. ncbi Anti-inflammatory activities of a kolaviron-inhibition of nitric oxide, prostaglandin E2 and tumor necrosis factor-alpha production in activated macrophage-like cell line
    S B Olaleye
    Department of Physiology, University of Ibadan, Ibadan, Nigeria
    Afr J Med Med Sci 39:41-6. 2010
    Kolaviron (KV), a biflavonoid fraction from the seeds of Garcinia kola has been shown to posess antiinflammatory properties in animal models of inflammation...
  34. ncbi Kolaviron, a biflavonoid complex from Garcinia kola seeds, ameliorates ethanol-induced reproductive toxicity in male wistar rats
    Oluwatosin A Adaramoye
    Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan
    Niger J Physiol Sci 28:9-15. 2013
    In previous studies, we established that kolaviron (KV) (a biflavonoid from Garcinia kola seeds) elicited anti-oxidative and hepatoprotective effects in Wistar rats chronically treated with ethanol...
  35. doi Kolaviron prevents carbendazim-induced steroidogenic dysfunction and apoptosis in testes of rats
    I A Adedara
    Department of Biochemistry and Molecular Biology, School of Life Sciences, Pondicherry University, Pondicherry 605014, India
    Environ Toxicol Pharmacol 35:444-53. 2013
    The study evaluated the protective role of kolaviron (an isolated biflavonoid from the seed of Garcinia kola) and vitamin E in carbendazim-induced reproductive dysfunction in male rats...
  36. pmc The microstructural effects of aqueous extract of Garcinia kola (Linn) on the hippocampus and cerebellum of malnourished mice
    Sunday A Ajayi
    Department of Anatomy, College of Health Sciences, Osun State University, Osogbo Osun State
    Asian Pac J Trop Biomed 1:261-5. 2011
    To assess the neuroprotective effects of aqueous extract of Garcinia kola on neurotoxin administered malnourished mice adopting histological procedure.
  37. pmc Kolaviron, a Garcinia biflavonoid complex ameliorates hyperglycemia-mediated hepatic injury in rats via suppression of inflammatory responses
    Omolola R Ayepola
    Department of Biomedical Sciences, Cape Peninsula, Oxidative Stress Research Centre, University of Technology, Bellville, South Africa
    BMC Complement Altern Med 13:363. 2013
    ..Kolaviron (KV), a natural biflavonoid from Garcinia kola seeds have been shown to possess anti- inflammatory properties which has not been explored in diabetes...
  38. doi In-vitro antagonistic characteristics of crude aqueous and methanolic extracts of Garcinia kola (Heckel) seeds against some Vibrio bacteria
    Dambudzo Penduka
    Applied and Environmental Microbiology Research Group AEMREG, Department of Biochemistry and Microbiology, University of Fort Hare, Alice, South Africa
    Molecules 16:2754-65. 2011
    The methanolic and aqueous extracts of Garcinia kola seeds were screened for their anti-Vibrio activities against 50 Vibrio isolates obtained from wastewater final effluents in the Eastern Cape Province, South Africa...
  39. doi Crude ethanolic extracts of Garcinia kola seeds Heckel (Guttiferae) prolong the lag phase of Helicobacter pylori: inhibitory and bactericidal potential
    Collise Njume
    School of Biological and Environmental Sciences, Faculty of Science and Agriculture, University of Fort Hare, Alice, South Africa
    J Med Food 14:822-7. 2011
    ..to identify potential sources of such compounds, the antimicrobial activity of five solvent extracts of Garcinia kola seeds were investigated against 30 clinical strains of H...
  40. doi Anticariogenic potentials of clove, tobacco and bitter kola
    Dibua Esther Uju
    Department of Microbiology, University of Nigeria, Nsukka 410001, Enugu State, Nigeria
    Asian Pac J Trop Med 4:814-8. 2011
    ..aromaticum)], bitter kola fruits [Garcinia kola (G. kola)] and tobacco leaves (Nicotiana species) as potential targeted killers of Streptococcus mutans (S...
  41. ncbi Anti-ulcerogenic and proton pump (H+, K+ ATPase) inhibitory activity of Kolaviron from Garcinia kola Heckel in rodents
    Samuel A Onasanwo
    Department of Physiology, Faculty of Basic Medical Sciences, College of Medicine, University of Ibadan, Ibadan, Nigeria
    Indian J Exp Biol 49:461-8. 2011
    Anti-ulcer potential and proton pump inhibitory activity of kolaviron (KV) isolated from Garcinia kola Heckel has been evaluated using different ulcer models...
  42. doi Kolaviron protects apoptotic cell death in PC12 cells exposed to atrazine
    Sunny O Abarikwu
    Department of Chemical Sciences, College of Natural Sciences, Redeemer s University, Redemption City, Ogun State, Nigeria
    Free Radic Res 45:1061-73. 2011
    Kolaviron (KV), a natural biflavonoid obtained from the seeds of Garcinia kola, has been documented for its wide pharmacological window, including anti-apoptotic activities...
  43. pmc Antioxidative and chemopreventive properties of Vernonia amygdalina and Garcinia biflavonoid
    Ebenezer O Farombi
    Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, University of Ibadan, Ibadan, Nigeria
    Int J Environ Res Public Health 8:2533-55. 2011
    ..These compounds elicit various biological effects including cancer chemoprevention. Garcinia kola (Guttiferae) seed, known as "bitter kola", plays an important role in African ethnomedicine and traditional ..
  44. pmc Detection of a gentamicin-resistant burn wound strain of pseudomonas aeruginosa but sensitive to honey and garcinia kola (heckel) seed extract
    O E Adeleke
    Department of Pharmaceutical Microbiology, University of Ibadan, Ibadan, Nigeria
    Ann Burns Fire Disasters 23:102-5. 2010
    ..Both the methanolic extract concentrate of Garcinia kola (Heckel) seeds and natural honey have been associated with activity on bacterial isolates from respiratory ..
  45. pmc Aqueous and Organic Solvent-Extracts of Selected South African Medicinal Plants Possess Antimicrobial Activity against Drug-Resistant Strains of Helicobacter pylori: Inhibitory and Bactericidal Potential
    Collise Njume
    School of Biological and Environmental Sciences, Faculty of Science and Agriculture, University of Fort Hare, P Bag X1314, Alice 5700, South Africa E Mails C N A A J
    Int J Mol Sci 12:5652-65. 2011
    ..Solvent-extracts of selected medicinal plants; Combretum molle, Sclerocarya birrea, Garcinia kola, Alepidea amatymbica and a single Strychnos species were investigated against 30 clinical strains of H...
  46. ncbi Ex-vivo and in vitro protective effects of kolaviron against oxygen-derived radical-induced DNA damage and oxidative stress in human lymphocytes and rat liver cells
    E Olatunde Farombi
    Institute of Food Safety and Nutrition, Division of Biochemical and Molecular Toxicology, 2860 Søborg, Denmark
    Cell Biol Toxicol 20:71-82. 2004
    The present study reports the protective effects of kolaviron, a Garcinia biflavonoid from the seeds of Garcinia kola widely consumed in some West African countries against oxidative damage to molecular targets ex-vivo and in vitro...
  47. pmc Traditional management of tuberculosis in Ogun State of Nigeria: the practice and ethnobotanical survey
    Omonike O Ogbole
    Department of Pharmacognosy, Faculty of Pharmacy, Olabisi Onabanjo University, Sagamu, Nigeria
    Afr J Tradit Complement Altern Med 7:79-84. 2010
    ..Cola acumminata (fruit), Garcinia kola (leaf), Vitallaria parodoxa (oil), Costus afer (stem), Pycnanthus angolensis (stem bark) and Aframomum ..
  48. doi Proapoptotic effects of long-chain vitamin E metabolites in HepG2 cells are mediated by oxidative stress
    Marc Birringer
    Department of Human Nutrition, Institute of Nutrition, Friedrich Schiller University of Jena, Jena, Germany
    Free Radic Biol Med 49:1315-22. 2010
    ..were synthesized from garcinoic acid, a δ-tocotrienol derivative extracted from the African bitter nut Garcinia kola. Both α- and δ-13'-carboxychromanol induced cell death in HepG2 cells at EC(50) of 13.5 and 6...
  49. doi Configuration of the vitamin E analogue garcinoic acid extracted from Garcinia Kola seeds
    Francesco Mazzini
    Dipartimento di Chimica e Chimica Industriale, Universita di Pisa, Pisa 56126, Italy
    Chirality 21:519-24. 2009
    ..Garcinoic acid (trans-13'-carboxy-delta-tocotrienol) is a vitamin E analog extracted from Garcinia Kola seeds in which the carboxylic group is at the end of the aliphatic side chain and reported to be a racemate ..
  50. ncbi Immunomodulatory activities of kolaviron, a mixture of three related biflavonoids of Garcinia kola Heckel
    C S Nworu
    Department of Pharmacology and Toxicology, University of Nigeria, Nsukka, Enugu State, Nigeria
    Immunopharmacol Immunotoxicol 30:317-32. 2008
    The immunomodulatory properties of kolaviron (KV), a mixture of three related biflavonoids of Garcinia kola Heckel (Clusiaceae), were investigated...
  51. ncbi Amino acid composition of two masticatory nuts (Cola acuminata and Garcinia kola) and a snack nut (Anacardium occidentale)
    E I Adeyeye
    Chemistry Department, University of Ado Ekiti, PMB 5363, Ado Ekiti, Nigeria
    Int J Food Sci Nutr 58:241-9. 2007
    The amino acid compositions of Cola acuminata, Garcinia kola and Anacardium occidentale were evaluated by ion-exchange chromatography. Glutamic acid was the most concentrated acid in the samples. In all the amino acids determined, A...
  52. ncbi Protection against 2- acetyl aminofluorene-induced toxicity in mice by garlic (Allium sativum), bitter kola (Garcina kola seed) and honey
    O A Odunola
    Cancer Research and Molecular Biology Laboratories, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria
    Afr J Med Med Sci 34:167-72. 2005
    ..These findings suggest that honey, garlic and bitter kola protect against 2-AAF-induced gamma-GTactivity and micronuleated PCEs formation...
  53. ncbi Hypoglycaemic and hypolipidaemic effects of fractions from kolaviron, a biflavonoid complex from Garcinia Kola in streptozotocin-induced diabetes mellitus rats
    O A Adaramoye
    Drug Metabolism and Toxicology Unit, Department of Biochemistry, College of Medicine, University of Ibadan, Nigeria
    J Pharm Pharmacol 58:121-8. 2006
    ..as alternatives to synthetic ones that are expensive and not easily accessible, and to justify the use of Garcinia kola seeds in traditional African medicine to treat diabetes, the hypoglycaemic and hypolipidaemic effects of ..
  54. ncbi Anti-oxidant mechanisms of kolaviron: studies on serum lipoprotein oxidation, metal chelation and oxidative membrane damage in rats
    E O Farombi
    Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine, University of Ibadan, Nigeria
    Clin Exp Pharmacol Physiol 32:667-74. 2005
    1. In the present study, we have examined the ability of kolaviron, a natural biflavonoid from Garcinia kola seeds, to prevent the susceptibility of rat serum lipoprotein to undergo oxidative modification in vitro and ex vivo...
  55. ncbi Chemoprevention of aflatoxin B1-induced genotoxicity and hepatic oxidative damage in rats by kolaviron, a natural bioflavonoid of Garcinia kola seeds
    E O Farombi
    Drug Metabolism and Toxicology Unit, Department of Biochemistry, College of Medicine, University of Ibadan, Nigeria
    Eur J Cancer Prev 14:207-14. 2005
    The chemopreventive effects of kolaviron, a natural antioxidant bioflavonoid from the seeds of Garcinia kola, on aflatoxin B1 (AFB1)-induced genotoxicity and hepatic oxidative damage was investigated in rats...
  56. ncbi Possible anti-atherogenic effect of kolaviron (a Garcinia kola seed extract) in hypercholesterolaemic rats
    O A Adaramoye
    Drug Metabolism and Toxicology Unit, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria
    Clin Exp Pharmacol Physiol 32:40-6. 2005
    ..This reduction and the favourable lipid profile indicate a possible anti-atherogenic property of the extract...
  57. ncbi Post-harvest fungal quality of selected chewing sticks
    E Etebu
    Department of Biological Sciences, Plant Pathology Unit, Rivers State University of Science and Technology, Rivers State, Port Harcourt, Nigeria
    Oral Dis 9:95-8. 2003
    ..To study post-harvest fungal overgrowth on chewing sticks used for oral hygiene measures and role of disinfection...
  58. ncbi Powerful antioxidative agents based on garcinoic acid from Garcinia kola
    Kenji Terashima
    Faculty of Pharmacy, Meijo University, Tempaku, 468 8503, Nagoya, Japan
    Bioorg Med Chem 10:1619-25. 2002
    Investigation on the structure--antioxidative activity relationships of derivatives based on garcinoic acid from Garcinia kola (Guttiferae) led to discovery of a powerful antioxidative agent.
  59. doi Hepatoprotective activity of purified fractions from Garcinia kola seeds in mice intoxicated with carbon tetrachloride
    O A Adaramoye
    Department of Biochemistry, University of Ibadan, Ibadan, Nigeria
    J Med Food 11:544-50. 2008
    The hepatoprotective activity of kolaviron (KV), a biflavonoid complex from Garcinia kola seeds, and its purified fractions was investigated in mice intoxicated with carbon tetrachloride (CCl(4))...
  60. ncbi Pupillary changes among Nigerian adults following the instillation of Garcinia kola nut extracts: multicentric studies
    A O Adefule-Ositelu
    Lagos University Teaching Hospital, Logos
    Niger Postgrad Med J 15:152-6. 2008
    ..A multi-centre, open, within-patient controlled study was performed on 106 adult volunteers to investigate the effects of Garcinia kolanut extracts on the pupillary sizes...
  61. pmc Efficacy of Garcinia kola 0.5% Aqueous Eye Drops in Patients with Primary Open-Angle Glaucoma or Ocular Hypertension
    Adebukunola O Adefule-Ositelu
    Department of Ophthalmology, Lagos University Teaching Hospital, Idi Araba, Lagos
    Middle East Afr J Ophthalmol 17:88-93. 2010
    To evaluate the intraocular pressure (IOP) lowering efficacy of Garcinia kola 0.5% aqueous solution eye drops in patients with newly diagnosed primary open-angle glaucoma or ocular hypertension (POAG/OH).
  62. pmc Antimicrobial effects of three tropical plant extracts on Staphylococcus aureus, Escherichia coli and Candida albicans
    R N Okigbo
    Department of Botany, Nnamdi Azikiwe University, Awka, Anambra State, Nigeria
    Afr J Tradit Complement Altern Med 5:226-9. 2008
    ..extracts of Cymbopogon citatrus (lemongrass) and Vernonia amygdalina (bitter leaf) and the seed extracts of Garcinia kola (bitter kola) were carried out. G...
  63. pmc Protective effect of garcinia kola (kolaviron) extract on predisposition of rats to cardiovascular diseases following separate administration of amodiaquine and artesunate
    Eo Ajani
    Department of Biochemistry, Faculty of Basic Medical Sciences, Olabisi Onabanjo University, Remo Campus, Ikenne
    Afr J Tradit Complement Altern Med 5:180-6. 2008
    ..cardiovascular effect of administration of antimalarial drugs amodiaquine and artesunate and the efficacy of Garcinia kola extract (kolaviron) in protecting against such possible effect...
  64. ncbi Comparative effects of vitamin E and kolaviron (a biflavonoid from Garcinia kola) on carbon tetrachloride-induced renal oxidative damage in mice
    O A Adaramoye
    Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria
    Pak J Biol Sci 12:1146-51. 2009
    ..E) and kolaviron (KV), a biflavonoid complex from the seeds of Garcinia kola are well documented...
  65. ncbi The in-vitro antimicrobial activity of some medicinal plants against beta-lactam-resistant bacteria
    Joseph Gangoue-Pieboji
    Centre for Research on Medicinal Plants and Traditional Medicine, Institute of Medical Research and Medicinal Plant Studies, Yaounde, Cameroon
    J Infect Dev Ctries 3:671-80. 2009
    ..In effort to identify novel bacterial agents, this study was initiated to evaluate the antimicrobial properties of 17 crude extracts from 12 medicinal plants against beta-lactam-resistant bacteria...
  66. ncbi Effect of dietary Garcinia kola seed on selected serum electrolytes and trace metals in male Albino rats
    P O Agada
    Department of Pharmacology, College of Medical Sciences University of Calabar, Calabar, Nigeria
    Niger J Physiol Sci 24:53-7. 2009
    The effects of various doses of dietary intake of Garcinia kola seed powder [incorporated in animal feed at levels of 5% w/w, 10% w/w and 20% w/w and fed daily for six weeks] on serum levels of selected electrolytes [K+, Na+, CI-, HCO3-, ..
  67. ncbi Effect of gavage treatment with pulverised Garcinia kola seeds on erythrocyte membrane integrity and selected haematological indices in male albino Wistar rats
    A A Ahumibe
    Department of Pharmacology, Faculty of Basic Medical Sciences, University of Calabar, Calabar Nigeria
    Niger J Physiol Sci 24:47-52. 2009
    This study examines the effect of the whole seed of Garcinia kola [GKS] on various blood parameters, in adult male albino rats...
  68. doi Alpha-glucosidase inhibitory, aromatase inhibitory, and antiplasmodial activities of a biflavonoid GB1 from Garcinia kola stem bark
    Bassey S Antia
    Chulabhorn Research Institute, Vibhavadi Rangsit Highway, Bangkok, Thailand
    Planta Med 76:276-7. 2010
    ..known as GB1 (1), was isolated as a major constituent from Garcinia kola stem bark...
  69. ncbi Susceptibility of cariogenic Streptococcus mutans to extracts of Garcinia kola, Hibiscus sabdariffa, and Solanum americanum
    O C Afolabi
    School of Dentistry, College of Medicine, University of Lagos, Nigeria
    West Afr J Med 27:230-3. 2008
    ..Avariety of plants with potent activity are known to be used in indigenous communities for dental hygiene worldwide...
  70. ncbi Stability of cough linctus (streptol) formulated from named medicinal plant extracts
    Maurice Iwu
    International Centre for Ethno Medicine and Drug Discovery InterCEDD, Nsukka, Enugu State Nigeria
    Chem Pharm Bull (Tokyo) 57:229-32. 2009
    Extracts of named medicinal herbs (Garcinia kola, Zingiber oificinale, Aframonum melequeta and Ocimum viride) were formulated into an antitussive preparation to alleviate cough...
  71. doi Kolaviron inhibits dimethyl nitrosamine-induced liver injury by suppressing COX-2 and iNOS expression via NF-kappaB and AP-1
    Ebenezer O Farombi
    Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 151 742, South Korea
    Life Sci 84:149-55. 2009
    Kolaviron, a bioflavonoid isolated from the seeds of Garcinia kola has been reported to possess anti-inflammatory, antioxidant, antigenotoxic and hepatoprotective activities in model systems via multiple biochemical mechanisms...
  72. ncbi Kolaviron modulates cellular redox status and impairment of membrane protein activities induced by potassium bromate (KBrO(3)) in rats
    E Olaunde Farombi
    Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, University of Ibadan, Ibadan, Nigeria
    Pharmacol Res 45:63-8. 2002
    In this study, we examined the modulatory effects of kolaviron, a biflavonoid from Garcinia kola seeds on the antioxidant defense mechanisms, cellular redox status and oxidative stress in the kidney and liver of rats pretreated with ..