garcinia

Summary

Summary: A plant genus of the family CLUSIACEAE.

Top Publications

  1. ncbi Xanthones from the green fruit hulls of Garcinia mangostana
    Sunit Suksamrarn
    Department of Chemistry, Faculty of Science, Srinakharinwirot University, Bangkok 10110, Thailand
    J Nat Prod 65:761-3. 2002
  2. ncbi Tetraoxygenated xanthones from the fruits of Garcinia cowa
    Kanda Panthong
    Department of Chemistry, Faculty of Science, Prince of Songkla University, Songkhla 90112, Thailand
    Phytochemistry 67:999-1004. 2006
  3. ncbi Afzeliixanthones A and B, two new prenylated xanthones from Garcinia afzelii ENGL. (Guttiferae)
    Alain François Kamdem Waffo
    Department of Chemistry, Faculty of Science, University of Douala, Cameroon
    Chem Pharm Bull (Tokyo) 54:448-51. 2006
  4. ncbi Gambogic acid and epigambogic acid, C-2 epimers with novel anticancer effects from Garcinia hanburyi
    Quanbin Han
    Chinese Medicine Laboratory, Hong Kong Jockey Club Institute of Chinese Medicine, Shatin, NT, PR China
    Planta Med 72:281-4. 2006
  5. ncbi Xanthones and benzophenones from Garcinia griffithii and Garcinia mangostana
    Lien Hoa D Nilar Nguyen
    Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543, Republic of Singapore
    Phytochemistry 66:1718-23. 2005
  6. ncbi Polyisoprenylated benzophenone, garcinol, a natural histone acetyltransferase inhibitor, represses chromatin transcription and alters global gene expression
    Karanam Balasubramanyam
    Transcription and Disease Laboratory, Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur, Bangalore 560064, India
    J Biol Chem 279:33716-26. 2004
  7. pmc Gambogic acid inhibits TNF-α-induced invasion of human prostate cancer PC3 cells in vitro through PI3K/Akt and NF-κB signaling pathways
    Lei Lu
    Department of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    Acta Pharmacol Sin 33:531-41. 2012
  8. ncbi Antiproliferation, antioxidation and induction of apoptosis by Garcinia mangostana (mangosteen) on SKBR3 human breast cancer cell line
    Primchanien Moongkarndi
    Department of Microbiology, Faculty of Pharmacy, Mahidol University, Sri Ayudthaya Road, Rajdhevee, Bangkok 10400, Thailand
    J Ethnopharmacol 90:161-6. 2004
  9. pmc Emerging role of Garcinol, the antioxidant chalcone from Garcinia indica Choisy and its synthetic analogs
    Subhash Padhye
    Department of Pathology, Barbara Ann Karmanos Cancer Center and Wayne State University School of Medicine, Detroit, MI 48201, USA
    J Hematol Oncol 2:38. 2009
  10. ncbi Biological activities of extracts from endophytic fungi isolated from Garcinia plants
    Souwalak Phongpaichit
    Natural Products Research Unit, Department of Microbiology, Faculty of Science, Prince of Songkla University, Songkhla, Thailand
    FEMS Immunol Med Microbiol 51:517-25. 2007

Research Grants

  1. TOTAL SYNTHESIS OF NATURAL PRODUCTS
    K Nicolaou; Fiscal Year: 2002
  2. SYNTHESIS OF ANTICANCER AGENTS
    K C Nicolaou; Fiscal Year: 2010
  3. Investigations of botanicals on food intake, satiety, weight loss, and oxidative
    Stephen D Anton; Fiscal Year: 2013
  4. Mangostin: A Dietary-Based Xanthone For Prostate Cancer Chemoprevention
    Jeremy James Johnson; Fiscal Year: 2010
  5. Chemical Biology of Caged Garcinia Xanthones
    Emmanuel A Theodorakis; Fiscal Year: 2012
  6. Transcriptional Regulaton of Pro-Inflammatory Genes by Gambogic Acid
    KUMBLE SANDEEP PRABHU; Fiscal Year: 2009
  7. Total Synthesis of Cytotoxic Garcinia Natural Products
    TRISTAN LAMBERT; Fiscal Year: 2005
  8. TOTAL SYNTHESIS OF AZADIRACHTIN
    K Nicolaou; Fiscal Year: 2008
  9. Enabling Technologies for Combinatorial Chemistry
    K Nicolaou; Fiscal Year: 2005
  10. TOTAL SYNTHESIS OF APOPTOLIDIN
    K Nicolaou; Fiscal Year: 2004

Detail Information

Publications195 found, 100 shown here

  1. ncbi Xanthones from the green fruit hulls of Garcinia mangostana
    Sunit Suksamrarn
    Department of Chemistry, Faculty of Science, Srinakharinwirot University, Bangkok 10110, Thailand
    J Nat Prod 65:761-3. 2002
    ..mangostenol (1), mangostenone A (2), and mangostenone B (3), were isolated from the green fruit hulls of Garcinia mangostana, along with the known xanthones, trapezifolixanthone, tovophyllin B (4), alpha- and beta-mangostins, ..
  2. ncbi Tetraoxygenated xanthones from the fruits of Garcinia cowa
    Kanda Panthong
    Department of Chemistry, Faculty of Science, Prince of Songkla University, Songkhla 90112, Thailand
    Phytochemistry 67:999-1004. 2006
    ..10 previously reported tetraoxygenated xanthones, were isolated from the crude hexane extract of the fruits of Garcinia cowa. Cowaxanthone B has previously been reported as a synthetic xanthone...
  3. ncbi Afzeliixanthones A and B, two new prenylated xanthones from Garcinia afzelii ENGL. (Guttiferae)
    Alain François Kamdem Waffo
    Department of Chemistry, Faculty of Science, University of Douala, Cameroon
    Chem Pharm Bull (Tokyo) 54:448-51. 2006
    ..beta-sitosterol and stigmasterol, were isolated from the CH2Cl2/MeOH (1:1) extract of the stem bark of Garcinia afzelii ENGL. collected in the South West Province of Cameroon...
  4. ncbi Gambogic acid and epigambogic acid, C-2 epimers with novel anticancer effects from Garcinia hanburyi
    Quanbin Han
    Chinese Medicine Laboratory, Hong Kong Jockey Club Institute of Chinese Medicine, Shatin, NT, PR China
    Planta Med 72:281-4. 2006
    ..stereomeric mixture of C-2 epimers, was newly separated into two epimers (1 and 2) from the gamboges of Garcinia hanburyi...
  5. ncbi Xanthones and benzophenones from Garcinia griffithii and Garcinia mangostana
    Lien Hoa D Nilar Nguyen
    Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543, Republic of Singapore
    Phytochemistry 66:1718-23. 2005
    ..1,3,6,7-tetrahydroxyxanthone and 1,3,5,6-tetrahydroxyxanthone were isolated from the stem bark of Garcinia griffithii...
  6. ncbi Polyisoprenylated benzophenone, garcinol, a natural histone acetyltransferase inhibitor, represses chromatin transcription and alters global gene expression
    Karanam Balasubramanyam
    Transcription and Disease Laboratory, Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur, Bangalore 560064, India
    J Biol Chem 279:33716-26. 2004
    ..Here we report that garcinol, a polyisoprenylated benzophenone derivative from Garcinia indica fruit rind, is a potent inhibitor of histone acetyltransferases p300 (IC50 approximately 7 microm) and ..
  7. pmc Gambogic acid inhibits TNF-α-induced invasion of human prostate cancer PC3 cells in vitro through PI3K/Akt and NF-κB signaling pathways
    Lei Lu
    Department of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    Acta Pharmacol Sin 33:531-41. 2012
    ..To investigate the mechanisms underlying the inhibitory effect of gambogic acid (GA) on TNF-α-induced metastasis of human prostate cancer PC3 cells in vitro...
  8. ncbi Antiproliferation, antioxidation and induction of apoptosis by Garcinia mangostana (mangosteen) on SKBR3 human breast cancer cell line
    Primchanien Moongkarndi
    Department of Microbiology, Faculty of Pharmacy, Mahidol University, Sri Ayudthaya Road, Rajdhevee, Bangkok 10400, Thailand
    J Ethnopharmacol 90:161-6. 2004
    ..antiproliferative, apoptotic and antioxidative properties of crude methanolic extract (CME) from the pericarp of Garcinia mangostana (family Guttiferae) using human breast cancer (SKBR3) cell line as a model system...
  9. pmc Emerging role of Garcinol, the antioxidant chalcone from Garcinia indica Choisy and its synthetic analogs
    Subhash Padhye
    Department of Pathology, Barbara Ann Karmanos Cancer Center and Wayne State University School of Medicine, Detroit, MI 48201, USA
    J Hematol Oncol 2:38. 2009
    Garcinol, harvested from Garcinia indica, has traditionally been used in tropical regions and appreciated for centuries; however its biological properties are only beginning to be elucidated...
  10. ncbi Biological activities of extracts from endophytic fungi isolated from Garcinia plants
    Souwalak Phongpaichit
    Natural Products Research Unit, Department of Microbiology, Faculty of Science, Prince of Songkla University, Songkhla, Thailand
    FEMS Immunol Med Microbiol 51:517-25. 2007
    Sixty-five crude extracts from 51 selected endophytic fungi isolated from Garcinia species were tested for various bioactivities...
  11. ncbi Anti-inflammatory and antinociceptive effects of Garcinia brasiliensis
    Flávia V Santa-Cecília
    Faculty of Pharmaceutical Sciences, Federal University of Alfenas MG, 37130 000 Alfenas, Brazil
    J Ethnopharmacol 133:467-73. 2011
    In Brazilian folk medicine, the leaves of Garcinia brasiliensis are used to treat tumors, inflammation of the urinary tract and arthritis as well as to relieve pain...
  12. ncbi Cytotoxic benzophenone derivatives from Garcinia species display a strong apoptosis-inducing effect against human leukemia cell lines
    Kenji Matsumoto
    Gifu International Institute of Biotechnology, Kani gun, Gifu, Japan
    Biol Pharm Bull 26:569-71. 2003
    ..The growth inhibitory effects of isogarcinol and xanthochymol were more potent than that of garcinol, which is a well- known cytotoxic benzophenone derivative...
  13. ncbi Trypanocidal and antileishmanial dihydrochelerythrine derivatives from Garcinia lucida
    Jean Fotie
    Department of Chemistry, McGill University, 801 Sherbrooke Street West, Montreal, Quebec H3A 2K6, Canada
    J Nat Prod 70:1650-3. 2007
    Three benzo[ c]phenanthridine alkaloids have been isolated from the stem bark of Garcinia lucida: dihydrochelerythrine ( 1), 6-acetonyldihydrochelerythrine ( 2), and its new derivative, ( S)1''-(9,10-dihydro-2',3'-dihydroxy-7,8-dimethoxy-..
  14. ncbi Antimicrobial activity in cultures of endophytic fungi isolated from Garcinia species
    Souwalak Phongpaichit
    Natural Products Research Unit and Department of Microbiology, Faculty of Science, Prince of Songkla University, Hat Yai, Songkla, Thailand
    FEMS Immunol Med Microbiol 48:367-72. 2006
    ..for antimicrobial activity in endophytic fungi isolated from surface sterilized leaves and branches of five Garcinia plants, G. atroviridis, G. dulcis, G. mangostana, G. nigrolineata and G. scortechinii, found in southern Thailand...
  15. ncbi Antimalarial xanthones from Calophyllum caledonicum and Garcinia vieillardii
    Anne Emmanuelle Hay
    SONAS, UFR des Sciences Pharmaceutiques et Ingenierie de la Sante, 16, Bd Daviers, Angers, France
    Life Sci 75:3077-85. 2004
    ..isocudraniaxanthone A (11), 2-deprenylrheediaxanthone B (12) and 1,4,5-trihydroxyxanthone (13) were isolated from Garcinia vieillardii...
  16. ncbi Phenolic compounds from the flowers of Garcinia dulcis
    S Deachathai
    Department of Chemistry, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand
    Phytochemistry 67:464-9. 2006
    Dulcisxanthones C-F and dulcinone together with 22 known compounds were isolated from the flowers of Garcinia dulcis. Their structures were determined by spectroscopic methods...
  17. ncbi Antimalarial compounds from the root bark of Garcinia polyantha Olv
    Alain Meli Lannang
    Department of Organic Chemistry, University of Yaounde I, Cameroon
    J Antibiot (Tokyo) 61:518-23. 2008
    Eight compounds were isolated from the roots of Garcinia polyantha, and identified. Two of them, the xanthone garciniaxanthone I (1), and the triterpene, named garcinane (2), are reported as new natural products...
  18. ncbi Antibacterial caged-tetraprenylated xanthones from the fruits of Garcinia hanburyi
    Yaowapa Sukpondma
    Department of Chemistry, Faculty of Science, Prince of Songkla University, Songkhla, Thailand
    Chem Pharm Bull (Tokyo) 53:850-2. 2005
    A new caged-tetraprenylated xanthone, hanburinone (1), was isolated from the fresh fruits of Garcinia hanburyi together with four known caged-tetraprenylated xanthones; isomoreollin B (2), morellin (3), moreollic acid (4) and morellic ..
  19. ncbi Chemical constituents of Garcinia fusca: structure elucidation of eight new xanthones and their cancer chemopreventive activity
    Chihiro Ito
    Faculty of Pharmacy, Meijo University, Tempaku, Nagoya 468 8503, Japan
    J Nat Prod 66:200-5. 2003
    ..B (2), C (3), D (4), E (5), F (6), G (7), and H (8), together with eight known xanthones from the stem bark of Garcinia fusca collected in Thailand...
  20. ncbi Damnacanthal from the Congolese medicinal plant Garcinia huillensis has a potent preferential cytotoxicity against human pancreatic cancer PANC-1 cells
    Dya Fita Dibwe
    Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Phytother Res 26:1920-6. 2012
    ..8 µg/mL and 13.8 µg/mL, respectively) and CHCl(3) extracts of Garcinia huillensis (PC(50)  = 17.8 µg/mL) and Securidaca longepedunculata (PC(50)  = 23...
  21. ncbi New medicinal properties of mangostins: analgesic activity and pharmacological characterization of active ingredients from the fruit hull of Garcinia mangostana L
    Jihong Cui
    Department of Biological Science and Technology, School of Life Sciences, Sun Yat Sen University, Guangzhou, Guangdong Province 510275, People s Republic of China
    Pharmacol Biochem Behav 95:166-72. 2010
    The fruit hull of Garcinia mangostana L...
  22. ncbi Xanthones from the stem bark of Garcinia bracteata with growth inhibitory effects against HL-60 cells
    Sheng Li Niu
    Key Laboratory of Structure Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, PR China
    Phytochemistry 77:280-6. 2012
    ..2-5) together with twenty-six known compounds (6-31), were isolated from the ethanol extract of the stem bark of Garcinia bracteata. Their structures were elucidated via spectroscopic analyses...
  23. pmc The synthetic caged garcinia xanthone cluvenone induces cell stress and apoptosis and has immune modulatory activity
    Ayse Batova
    Department of Chemistry and Biochemistry, University of California, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Mol Cancer Ther 9:2869-78. 2010
    Several caged Garcinia xanthone natural products have potent bioactivity and a documented value in traditional Eastern medicine...
  24. ncbi In-vitro antagonistic characteristics of crude aqueous and methanolic extracts of Garcinia kola (Heckel) seeds against some Vibrio bacteria
    Dambudzo Penduka
    Applied and Environmental Microbiology Research Group AEMREG, Department of Biochemistry and Microbiology, University of Fort Hare, Alice, South Africa
    Molecules 16:2754-65. 2011
    The methanolic and aqueous extracts of Garcinia kola seeds were screened for their anti-Vibrio activities against 50 Vibrio isolates obtained from wastewater final effluents in the Eastern Cape Province, South Africa...
  25. ncbi Antileishmanial polyphenols from Garcinia vieillardii
    Anne Emmanuelle Hay
    SONAS, UFR des Sciences Pharmaceutiques et d Ingénierie de la Santé, 16 Bd Daviers, 49100 Angers, France
    Fitoterapia 79:42-6. 2008
    ..4) and 3-geranyl-2,4,6-trihydroxybenzophenone (5) were isolated from the stem bark of the neocaledonian Garcinia vieillardii...
  26. pmc GA3, a new gambogic acid derivative, exhibits potent antitumor activities in vitro via apoptosis-involved mechanisms
    Hua Xie
    Division of Antitumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
    Acta Pharmacol Sin 30:346-54. 2009
    ..acid (GA) is the major active ingredient of gamboge, which is secreted from a Chinese traditional medicine, Garcinia hanburyi, which possesses potent antitumor activity...
  27. ncbi General gambogic acids inhibited growth of human hepatoma SMMC-7721 cells in vitro and in nude mice
    Qing Long Guo
    Department of Physiology, 3Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China
    Acta Pharmacol Sin 25:769-74. 2004
    ..To study the inhibitory effect of general gambogic acids (GGA) on transplantation tumor SMMC-7721 in experimental animal model and SMMC-7721 cells in vitro...
  28. ncbi The constituents from the stems of Garcinia cowa Roxb. and their cytotoxic activities
    Jie Shen
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, People s Republic of China
    Pharmazie 62:549-51. 2007
    ..B, garccowaside C, and three other known compounds were isolated from the ethanol extract of the stems of Garcinia cowa. These structures were established on the basis of spectroscopic evidence...
  29. ncbi Cytotoxicity of natural compounds isolated from the seeds of Garcinia afzelii
    Alain Meli Lannang
    Department of Chemistry, Higher Teachers Training College, University of Maroua, Maroua, Cameroon
    Planta Med 76:708-12. 2010
    The new compounds guttiferone O ( 1) and 3-methoxycheffouxanthone ( 2) have been isolated from the seeds of Garcinia afzelii Engl...
  30. ncbi Composition, and anti-inflammatory and antioxidant activities of the volatile oil from the fruit peel of Garcinia brasiliensis
    Felipe T Martins
    Laboratorio de Cristalografía, Departamento de Ciências Exatas, Universidade Federal de Alfenas UNIFAL MG, Rua Gabriel Monteiro da Silva, 714, Alfenas MG, 37130 000, Brazil
    Chem Biodivers 5:251-8. 2008
    The composition of the volatile oil obtained by hydrodistillation from the fruit peel of Garcinia brasiliensis (Mart.) Planch. et Triana was determined by GC/MS. A total of 38 components were identified, including gamma-muurolene (10...
  31. ncbi Reduction of adipose tissue and body weight: effect of water soluble calcium hydroxycitrate in Garcinia atroviridis on the short term treatment of obese women in Thailand
    Chulaporn Roongpisuthipong
    Division of Nutrition and Biochemical Medicine, Department of Medicine, Ramathibodi Hospital, Faculty of Medicine, Mahidol University, Bangkok 10400, Thailand
    Asia Pac J Clin Nutr 16:25-9. 2007
    ..Group 1, with a mean (+/-SEM) age of 40.0+/-2 years, received water soluble calcium hydroxycitrate (HCA) as Garcinia atroviridis. Group 2, with a mean age of 35.6+/-1.8 years, received placebo...
  32. ncbi Anti-inflammatory effects of hydroalcoholic extract and two biflavonoids from Garcinia gardneriana leaves in mouse paw oedema
    Jaqueline C Castardo
    Department of Pharmacology, Universidade Federal do Parana, PR, Brazil
    J Ethnopharmacol 118:405-11. 2008
    b>Garcinia gardneriana (Planch. & Triana) Zappi (Clusiaceae) is widely distributed in Brazil and used in folk medicine to treat inflammation, pain, and urinary tract and other infections...
  33. ncbi Identification of 5-lipoxygenase and microsomal prostaglandin E2 synthase-1 as functional targets of the anti-inflammatory and anti-carcinogenic garcinol
    Andreas Koeberle
    Department for Pharmaceutical Analytics, Pharmaceutical Institute, University of Tuebingen, Auf der Morgenstelle 8, D 72076 Tuebingen, Germany
    Biochem Pharmacol 77:1513-21. 2009
    ....
  34. ncbi Cytotoxic activities of xanthochymol and isoxanthochymol substantiated by LC-MS/MS
    Satyanshu Kumar
    Central Institute of Medicinal and Aromatic Plants, P O CIMAP, Lucknow, India
    Planta Med 73:1452-6. 2007
    The methanol extract of the fruit rinds of Garcinia indica showed potent cytotoxic activity against three human cancer cell lines, colon (COLO-320-DM), breast (MCF-7) and liver (WRL-68), as determined by the MTT assay...
  35. ncbi Cytotoxic acylphloroglucinol derivatives from the twigs of Garcinia cowa
    Gang Xu
    Chinese Medicine Laboratory, Hong Kong Jockey Club Institute of Chinese Medicine, Shatin, Hong Kong, People s Republic of China
    J Nat Prod 73:104-8. 2010
    ..three other new (garcicowins B-D, 2-4) and nine known analogues, was isolated and characterized from the twigs of Garcinia cowa. The structures of 1-4 were elucidated by interpretation of their spectroscopic data...
  36. ncbi Effect of Garcinia cambogia extract on lipids and lipoprotein composition in dexamethasone administered rats
    P Mahendran
    Department of Biochemistry and Molecular Biology, University of Madras, Guindy Campus, Chennai-600 025
    Indian J Physiol Pharmacol 45:345-50. 2001
    Dexamethasone (10 mg/kg body weight/day, s.c.) administered rats were treated with or without Garcinia cambogia fruit extract (1 g/kg body weight/day, orally) for 8 days...
  37. ncbi Screening for tyrosinase inhibitors among extracts of seashore plants and identification of potent inhibitors from Garcinia subelliptica
    Toshiya Masuda
    Faculty of Integrated Arts and Sciences, University of Tokushima, Tokushima, Japan
    Biosci Biotechnol Biochem 69:197-201. 2005
    ..The extracts of Hibiscus tiliaceus, Carex pumila, and Garcinia subelliptica showed potent activity among them...
  38. ncbi Determination of organic acids in leaves and rinds of Garcinia indica (Desr.) by LC
    G K Jayaprakasha
    Human Resource Development, Central Food Technological Research Institute, Mysore 570 013, India
    J Pharm Biomed Anal 28:379-84. 2002
    Organic acids in leaves and rinds of Garcinia indica (Kokam) were determined by high-performance liquid chromatography. The major organic acid in leaves and rinds has been found to be (-)-hydroxycitric acid present to the extent of 4.1-4...
  39. ncbi Bangangxanthone A and B, two xanthones from the stem bark of Garcinia polyantha Oliv
    A Meli Lannang
    Department of Organic Chemistry, Faculty of Sciences, University of Yaounde I, P O Box 812, Yaounde, Cameroon
    Phytochemistry 66:2351-5. 2005
    ..triterpenoids, friedelin, oleanolic acid and lupeol were isolated from the chloroform extract of the stem bark of Garcinia polyantha. The structures of these compounds were assigned by spectroscopic analysis...
  40. ncbi High-performance liquid chromatography and LC-ESI-MS method for the identification and quantification of two biologically active polyisoprenylated benzophenones xanthochymol and isoxanthochymol in different parts of Garcinia indica
    Satyanshu Kumar
    Central Institute of Medicinal and Aromatic Plants, PO CIMAP, Lucknow 226015, India
    Biomed Chromatogr 21:139-63. 2007
    ..analysis of xanthochymol (1), and isoxanthochymol (2) in the fruit rinds, leaves and seed pericarps of Garcinia indica with confirmation using PDA detection and electrospray ionization MS...
  41. pmc Unified synthesis of caged Garcinia natural products based on a site-selective Claisen/Diels-Alder/Claisen rearrangement
    Eric J Tisdale
    Department of Chemistry and Biochemistry, University of California at San Diego, 9500 Gilman Drive, MC 0358, La Jolla, CA 92093 0358, USA
    Proc Natl Acad Sci U S A 101:12030-5. 2004
    A unified synthetic strategy toward caged Garcinia natural products has been designed and implemented...
  42. ncbi Antiaflatoxigenic and antioxidant activities of Garcinia extracts
    G S Joseph
    Human Resource Development, Central Food Technological Research Institute, Mysore 570 020, India
    Int J Food Microbiol 101:153-60. 2005
    The effect of hexane and chloroform extracts from the fruit rinds of Garcinia cowa and Garcinia pedunculata on the growth and aflatoxin production in Aspergillus flavus was studied using peanut powder as a model food system...
  43. ncbi High-performance liquid chromatography and LC-ESI-MS method for identification and quantification of two isomeric polyisoprenylated benzophenones isoxanthochymol and camboginol in different extracts of Garcinia species
    Satyanshu Kumar
    Central Institute of Medicinal and Aromatic Plants CIMAP, PO CIMAP, Lucknow 226015, India
    Biomed Chromatogr 23:888-907. 2009
    ..benzophenones, isoxanthochymol and camboginol, in the extracts of the stem bark, seeds and seed pericarps of Garcinia indica and in the fruit rinds of Garcinia cambogia...
  44. ncbi Effects of Garcinia atroviridis on serum profiles and atherosclerotic lesions in the aorta of guinea pigs fed a high cholesterol diet
    A A Amran
    Department of Physiology, Faculty of Medicine, University Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, Kuala Lumpur 50300, Malaysia
    Singapore Med J 50:295-9. 2009
    The fruit extract of Garcinia atroviridis (G. atroviridis) contains hydroxycitric acid and flavonoids, which have been reported to have a hypolipidaemic property...
  45. ncbi Polyprenylated benzophenones from Garcinia assigu and their potential cancer chemopreventive activities
    Chihiro Ito
    Faculty of Pharmacy, Meijo University, Tempaku, Nagoya 468 8503, Japan
    J Nat Prod 66:206-9. 2003
    In a further study on the chemical constituents of Garcinia assigu, two new benzophenones corresponding to the 13-O-methyl ethers (1 and 2) of the known isogarcinol and garcinol, respectively, were isolated and characterized, along with ..
  46. ncbi Liquid chromatography-tandem mass spectrometry method for identification and quantification of two biologically active polyisoprenylated benzophenones, isoxanthochymol and camboginol, in Garcinia species
    Sunil K Chattopadhyay
    Central Institute of Medicinal and Aromatic Plants, Lucknow 226015, India
    Biomed Chromatogr 21:1159-65. 2007
    ..benzophenones, isoxanthochymol and camboginol, in the extracts of the fruit rinds, stem bark, seed and leaves of Garcinia indica and in the fruit rinds of Garcinia cambogia...
  47. ncbi Rapid determination of polyprenylated xanthones in gamboge resin of Garcinia hanburyi by HPLC
    Jing Zheng Song
    Chinese Medicine Laboratory, Hong Kong Jockey Club Institute of Chinese Medicine, Shatin, N T, Hong Kong, China
    J Sep Sci 30:304-9. 2007
    ..acid (EIGA), gambogenic acid (GNA), gambogic acid (GA), and epigambogic acid (EGA), in gamboge resin of Garcinia hanburyi...
  48. ncbi Antibacterial xanthones from the leaves of Garcinia nigrolineata
    Vatcharin Rukachaisirikul
    Department of Chemistry, Faculty of Science, Prince of Songkla University, Songkhla, 90112, Thailand
    J Nat Prod 66:1531-5. 2003
    ..A (11), and one new isoflavone-like compound, nigrolineaisoflavone A (12), were isolated from the leaves of Garcinia nigrolineata along with four known xanthones and friedelin...
  49. ncbi Improved high-performance liquid chromatographic method for simultaneous determination of 12 cytotoxic caged xanthones in gamboges, a potential anticancer resin from Garcinia hanburyi
    Song Lin Li
    Chinese Medicine Laboratory, Hong Kong Jockey Club Institute of Chinese Medicine, Shatin, N T, Hong Kong, People s Republic of China
    Biomed Chromatogr 22:637-44. 2008
    The potential anti-tumor activity of gamboges, a herbal medicine derived from Garcinia hanburyi, has increasingly gained the interest of scientist worldwide. The major components of gamboges are cytotoxic caged xanthones...
  50. ncbi Identification and quantification of two biologically active polyisoprenylated benzophenones xanthochymol and isoxanthochymol in Garcinia species using liquid chromatography-tandem mass spectrometry
    Sunil K Chattopadhyay
    Central Institute of Medicinal and Aromatic Plants, P O CIMAP, Lucknow 226015, India
    J Chromatogr B Analyt Technol Biomed Life Sci 844:67-83. 2006
    ..xanthochymol and isoxanthochymol in the extracts of the fruit rinds, stem bark, seed pericarps and leaves of Garcinia indica and in the fruit rinds of Garcinia cambogia...
  51. ncbi Anti-inflammatory, analgesic and antipyretic activities of the extract of gamboge from Garcinia hanburyi Hook f
    Ampai Panthong
    Department of Pharmacology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand
    J Ethnopharmacol 111:335-40. 2007
    In Thai folklore medicine, gamboge, the yellow gum-resin secreted from Garcinia hanburyi, is used for infected wound, pain and edema The ethyl acetate extract from Garcinia hanburyi (GH5763) was assessed for anti-inflammatory, analgesic ..
  52. ncbi An antibacterial biphenyl derivative from Garcinia bancana MIQ
    Vatcharin Rukachaisirikul
    Department of Chemistry, Faculty of Science, Prince of Songkla University, Thailand
    Chem Pharm Bull (Tokyo) 53:342-3. 2005
    From the methanol extract of the twigs and leaves of Garcinia bancana MIQ...
  53. ncbi Cytotoxic prenylated xanthones from the young fruit of Garcinia mangostana
    Sunit Suksamrarn
    Department of Chemistry, Faculty of Science, Srinakharinwirot University, Sukhumvit, Bangkok, Thailand
    Chem Pharm Bull (Tokyo) 54:301-5. 2006
    ..and E (3), together with 16 known xanthones 4-19, were isolated from the young fruit (7-week maturity stage) of Garcinia mangostana...
  54. ncbi Oblongifolins A-D, polyprenylated benzoylphloroglucinol derivatives from Garcinia oblongifolia
    Wafaa Hamed
    Institut de Chimie des Substances Naturelles, CNRS, Avenue de la Terrasse, 91198 Gif sur Yvette Cedex, France
    J Nat Prod 69:774-7. 2006
    ..A-D (2-5), four new polyprenylated 3,4-dihydroxybenzoylphloroglucinol compounds, were isolated from the bark of Garcinia oblongifolia collected in Vietnam...
  55. ncbi Possible anti-atherogenic effect of kolaviron (a Garcinia kola seed extract) in hypercholesterolaemic rats
    O A Adaramoye
    Drug Metabolism and Toxicology Unit, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria
    Clin Exp Pharmacol Physiol 32:40-6. 2005
    1. The hypolipidaemic effect of kolaviron, a mixture of Garcinia biflavonoid 1 (GB1), Garcinia biflavonoid 2 (GB2) and kolaflavanone, used in the treatment of various ailments in southern Nigeria, was investigated in rats...
  56. ncbi Leishmanicidal activity of benzophenones and extracts from Garcinia brasiliensis Mart. fruits
    I O Pereira
    Department of Pharmacy, Laboratory of Phytochemistry and Medicinal Chemistry, Federal University of Alfenas, MG, Brazil
    Phytomedicine 17:339-45. 2010
    ..hexane, ethyl-acetate and ethanolic) and molecules both obtained by means of extraction from pericarps of Garcinia brasiliensis fruits...
  57. ncbi Qualitative and quantitative analysis of polycyclic polyprenylated acylphloroglucinols from Garcinia species using ultra performance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight tandem mass spectrometry
    Yan Zhou
    Hong Kong Jockey Club Institute of Chinese Medicine, Shatin, New Territories, Hong Kong, China
    Anal Chim Acta 678:96-107. 2010
    Polycyclic polyprenylated acylphloroglucinols (PPAPs) are a group of natural products isolated from different Garcinia species with a wide range of important biological activities...
  58. ncbi Benzopyrans, biphenyls and xanthones from the root of Garcinia linii and their activity against Mycobacterium tuberculosis
    Jih Jung Chen
    Department of Pharmacy, Tajen University, Pingtung, Taiwan, People s Republic of China
    Planta Med 72:473-7. 2006
    ..D, garcibiphenyl E, together with thirteen known compounds have been additionally isolated from the root of Garcinia linii. The structures of these new compounds were determined through spectral analyses...
  59. ncbi Cytotoxic and anti-HIV-1 caged xanthones from the resin and fruits of Garcinia hanburyi
    Vichai Reutrakul
    Department of Chemistry, Faculty of Science, Mahidol University, Bangkok, Thailand
    Planta Med 73:33-40. 2007
    ..acid (3), together with nine known caged xanthones were isolated from the EtOAc extracts of resin and fruits of Garcinia hanburyi. The structures were determined by spectroscopic methods...
  60. ncbi Two new xanthons from Garcinia rigida leaves
    Berna Elya
    Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, China
    Nat Prod Res 20:788-91. 2006
    ..Two new xanthons, musaxanthone (1) and asmaxanthone (2) were isolated from the leaves of Garciniarigida. The structures were determined by means of spectroscopic analysis...
  61. ncbi Antiparasitic activity of some xanthones and biflavonoids from the root bark of Garcinia livingstonei
    Zakaria H Mbwambo
    Institute of Traditional Medicine, Muhimbili University College of Health Sciences, Dar es Salaam, Tanzania
    J Nat Prod 69:369-72. 2006
    ..6), along with five known xanthones and two known biflavonoids, was isolated from the root bark of Garcinia livingstonei collected in Tanzania. The absolute configuration of 6 was established by CD spectroscopy...
  62. ncbi Xanthones from Garcinia mangostana (Guttiferae)
    G C L Ee
    Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia
    Nat Prod Res 20:1067-73. 2006
    Studies on the stem of Garcinia mangostana have led to the isolation of one new xanthone mangosharin (1) (2,6-dihydroxy-8-methoxy-5-(3-methylbut-2-enyl)-xanthone) and six other prenylated xanthones, alpha-mangostin (2), beta-mangostin (3),..
  63. ncbi A new benzophenone from the stem bark of Garcinia benthami
    Berna Elya
    Department of Pharmacy, Universitas Indonesia, Kampus UI Depok 16424, Indonesia
    Nat Prod Res 20:1059-62. 2006
    From the stem bark of Garcinia benthami a new benzophenone, named Salimbenzophenone, was isolated. The structure was determined by means of spectroscopic analysis.
  64. ncbi Studies on the toxicity of gambogic acid in rats
    Qi Qi
    Jiangsu Key Laboratory of Carcinogenesis and Intervention, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing, Jiangsu 210009, People s Republic of China
    J Ethnopharmacol 117:433-8. 2008
    ..of gambogic acid (GA), the major active ingredient of gamboges, a brownish to orange resin extracted from the Garcinia hanburyi (family Guttiferae) in Southeast Asia, using Sprague-Dawley rat as an animal model and provide further ..
  65. ncbi A new cytotoxic xanthone from Garcinia rigida
    Berna Elya
    Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, China
    Fitoterapia 79:182-4. 2008
    A new xanthone, yahyaxanthone (1), was isolated from Garcinia rigida leaves. Cytotoxicity evaluation showed that 1 was inhibitory to L1210 cell, with an IC50 value 4.08 microg/ml.
  66. ncbi Cytotoxic xanthones from Garcinia penangiana Pierre
    Md Lip Jabit
    Laboratory of Natural Products, Institute of Bioscience, University Putra Malaysia, 43400 Serdang, Selangor, Malaysia
    Z Naturforsch C 62:786-92. 2007
    ..C (4) and gerontoxanthone C (5), as well as friedelin and stigmasterol were isolated from the leaves of Garcinia penangiana...
  67. ncbi Phloroglucinols with prooxidant activity from Garcinia subelliptica
    Chien Chang Wu
    School of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan, Republic of China
    J Nat Prod 71:246-50. 2008
    ..and the tautomeric pair of garcinielliptone FC ( 2/ 2a) were isolated from the heartwood and pericarp of Garcinia subelliptica, respectively...
  68. ncbi Polyanxanthone A, B and C, three xanthones from the wood trunk of Garcinia polyantha Oliv
    Gabin Nselapi Louh
    Department of Organic Chemistry, Faculty of Science, University of Yaounde I, P O Box 812, Yaounde, Cameroon
    Phytochemistry 69:1013-7. 2008
    ..polyanxanthone A (1), B (2) and C (3) have been isolated from the methanol extract of the wood trunk of Garcinia polyantha, along with five known xanthones: 1,3,5-trihydroxyxanthone (4); 1,5-dihydroxyxanthone (5); 1,3,6,7-..
  69. ncbi Five novel prenylated xanthones from Resina Garciniae
    Feng Feng
    Department of Phytochemistry, China Pharmaceutical University, Nanjing, China
    J Asian Nat Prod Res 9:735-41. 2007
    Fourteen prenylated xanthone derivatives were isolated from gamboge, the dry latex of Garcinia hanburyi, and their structures were elucidated by a detailed spectroscopic analysis...
  70. ncbi Pharmacokinetics, tissue distribution and excretion of gambogic acid in rats
    Kun Hao
    Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, People s Republic of China
    Eur J Drug Metab Pharmacokinet 32:63-8. 2007
    ..In conclusion, the present observations indicated that GA was rapidly eliminated from the blood and transferred to the tissues. Moreover, the majority of GA appeared to be excreted into the bile within 16 h of i.v. administration...
  71. ncbi Cytotoxic caged-polyprenylated xanthonoids and a xanthone from Garcinia cantleyana
    Khalid A Shadid
    Laboratory of Natural Products, Institute of Bioscience, University Putra Malaysia, 43400 Serdang, Selangor, Malaysia
    Phytochemistry 68:2537-44. 2007
    Phytochemical studies on the leaves and trunk bark of Garcinia cantleyana yielded five caged-xanthonoids including one tetra- and four tri-prenylated xanthones, cantleyanone A (1), 7-hydroxyforbesione (2) and cantleyanones B-D (4-6), as ..
  72. ncbi Xanthones with growth inhibition against HeLa cells from Garcinia xipshuanbannaensis
    Quan Bin Han
    Chinese Medicine Laboratory, Hong Kong Jockey Club Institute of Chinese Medicine, Shatin, Hong Kong, PR China
    Phytochemistry 69:2187-92. 2008
    ..A-H (1-8), together with seven known compounds, were isolated from the acetone extract of the twigs of Garcinia xipshuanbannaensis. Their structures were elucidated by spectroscopic data interpretation...
  73. ncbi Two new xanthones isolated from the stem bark of Garcinia lancilimba
    Nian Yun Yang
    Chinese Medicine Laboratory, Hong Kong Jockey Club Institute of Chinese Medicine, Hong Kong, PR China
    Chem Pharm Bull (Tokyo) 55:950-2. 2007
    ..2), have been isolated from the stem bark of Garcinia lancilimba (Guttiferae), together with six known xanthones...
  74. ncbi Caspase-8 preferentially senses the apoptosis-inducing action of NG-18, a Gambogic acid derivative, in human leukemia HL-60 cells
    Zhijian Tao
    College of Chemistry and Life, Zhejiang Normal University, Jinhua Zhejiang, PR China
    Cancer Biol Ther 6:691-6. 2007
    Gambogic acid (GA) is the major active ingredient of gamboge secreted from a Chinese traditional medicine Garcinia hanburryi possessing potent anti-tumor activity...
  75. ncbi Induction of apoptosis by xanthones from mangosteen in human leukemia cell lines
    Kenji Matsumoto
    Gifu International Institute of Biotechnology, 1 1 Naka fudogaoka, Kakamigahara, Gifu 504 0838, Japan
    J Nat Prod 66:1124-7. 2003
    We examined the effects of six xanthones from the pericarps of mangosteen, Garcinia mangostana, on the cell growth inhibition of human leukemia cell line HL60. All xanthones displayed growth inhibitory effects...
  76. ncbi A pair of novel cytotoxic polyprenylated xanthone epimers from gamboges
    Quan Bin Han
    Laboratory of Chinese Medicine, Hong Kong Jockey Club Institute of Chinese Medicine, Hong Kong, PR China
    Chem Biodivers 3:101-5. 2006
    Two new polyprenylated xanthone epimers were isolated from gamboges of Garcinia hanburyi, and identified by detailed spectroscopic analysis as 30-hydroxygambogic acid (2a) and its (2S)-epimer 30-hydroxyepigambogic acid (2b)...
  77. ncbi Cytotoxicity of prenylated xanthones and other constituents from the wood of Garcinia merguensis
    Anake Kijjoa
    Instituto de Ciencias Biomedicas de Abel Salazar, Universidade do Porto, Porto, Portugal
    Planta Med 74:864-6. 2008
    ..5) and 3,3',4- O-trimethylellagic acid were isolated from the wood of GARCINIA MERGUENSIS Wight...
  78. ncbi Cytotoxic polyprenylated xanthones from the resin of Garcinia hanburyi
    Quan Bin Han
    Chinese Medicine Laboratory, Hong Kong Jockey Club Institute of Chinese Medicine
    Chem Pharm Bull (Tokyo) 54:265-7. 2006
    Thirteen xanthones (1-13) were isolated from the resin of Garcinia hanburyi...
  79. ncbi Xanthones from the bark of Garcinia merguensis
    Lien Hoa D Nguyen
    Department of Chemistry, College of Natural Sciences, National University of HoChiMinh City, 227 Nguyen Van Cu, HoChiMinh City, Viet Nam
    Phytochemistry 63:467-70. 2003
    The bark of Garcinia merguensis yielded 10 xanthones, merguenone, 1,5-dihydroxy-6'-methyl-6'-(4-methyl-3-pentenyl)-pyrano(2',3':3,2)-xanthone, subelliptenone H, 8-deoxygartanin, rheediaxanthone A, morusignin G, 6-deoxyjacareubin, 1,3,5-..
  80. ncbi Xanthones and benzophenones from the stems of Garcinia multiflora
    Yi Ming Chiang
    Department of Chemistry, National Taiwan University, Taipei, Taiwan, Republic of China
    J Nat Prod 66:1070-3. 2003
    ..maclurin (6), 2,4,6,3'-tetrahydroxybenzophenone (7), and naringenin, were isolated from the stems of Garcinia multiflora. The structures of 1-5 were elucidated by extensive analysis of their spectral data...
  81. ncbi Bioactive benzophenones from Garcinia xanthochymus fruits
    Scott Baggett
    Department of Biological Sciences, Lehman College and The Graduate School and University Center, The City University of New York, 250 Bedford Park Boulevard West, Bronx, New York 10468, USA
    J Nat Prod 68:354-60. 2005
    A MeOH extract of Garcinia xanthochymus fruits was subjected to activity-guided fractionation, yielding two new benzophenones, guttiferone H (1) and gambogenone (2). Compound 1 contains a seven-membered ring attached to the bicyclo[3.3...
  82. ncbi Antibacterial caged-tetraprenylated xanthones from the stem bark of Garcinia scortechinii
    Vatcharin Rukachaisirikul
    Department of Chemistry, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla, Thailand
    Planta Med 71:165-70. 2005
    ..trimethylfurano(2 '',3 '':3,4)- xanthone, were isolated from the crude methanol extract of the stem bark of Garcinia scortechinii...
  83. ncbi A geranylated biphenyl derivative from Garcinia malvgostana
    H R W Dharmaratne
    Natural Products Programme, Institute of Fundamental Studies, Kandy 20000, Sri Lanka
    Nat Prod Res 19:239-43. 2005
    Extracts of root bark, stem bark and the latex collected from the green fruits of Garcinia mangostana gave alpha-mangostin, beta-mangostin, gamma-mangostin, garcinone-E, methoxy-beta-mangostin and a new geranylated biphenyl derivative 3-..
  84. ncbi Cytotoxic xanthones and biphenyls from the root of Garcinia linii
    Jih Jung Chen
    Department of Pharmacy, Tajen Institute of Technology, Pingtung, Taiwan, Republic of China
    Planta Med 70:1195-200. 2004
    ..garcibenzopyran, together with twelve known xanthones and a known biphenyl have been isolated from the root of Garcinia linii. The structures of these new compounds were determined through spectral analyses...
  85. ncbi Trypanocidal constituents in plants 2.xanthones from the stem bark of Garcinia subelliptica
    Fumiko Abe
    Faculty of Pharmaceutical Sciences, Fukuoka University
    Biol Pharm Bull 26:1730-3. 2003
    The constituents of the stem bark of Garcinia subelliptica (Guttiferae) were investigated based on its trypanocidal activity against epimastigotes of Trypanosoma cruzi, the etiologic agent for Chagas' disease...
  86. ncbi Anti-HIV-1 protostane triterpenes and digeranylbenzophenone from trunk bark and stems of Garcinia speciosa
    Vatcharin Rukachaisirikul
    Department of Chemistry, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla, Thailand
    Planta Med 69:1141-6. 2003
    ..from the ethyl acetate fractions obtained from the crude methanol extracts of the trunk bark and stems of Garcinia speciosa. The structures were elucidated by spectroscopic methods and chemical reactions...
  87. ncbi Lanostanes and friedolanostanes from the bark of Garcinia speciosa
    Luis M M Vieira
    Departamento de Quimica, Universidade de Aveiro, 3810 193 Aveiro, Portugal
    Phytochemistry 65:393-8. 2004
    The CHCl(3) extract of the bark of Garcinia speciosa contained four 17,14-friedolanostanes and five lanostanes as well as friedelin and common plant constituents...
  88. ncbi In vitro inhibitory effect of rubraxanthone isolated from Garcinia parvifolia on platelet-activating factor receptor binding
    Ibrahim Jantan
    Department of Pharmacy, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia
    Planta Med 68:1133-4. 2002
    Rubraxanthone and isocowanol isolated from Garcinia parvifolia Miq. were investigated for their inhibitory effects on platelet-activating factor (PAF) binding to rabbit platelets using 3H-PAF as a ligand...
  89. ncbi Antioxidant xanthones from Garcinia vieillardii
    Anne Emmanuelle Hay
    SONAS, UFR des Sciences Pharmaceutiques et Ingenierie de la Sante, 16 Bd Daviers, F 49100 Angers, France
    J Nat Prod 67:707-9. 2004
    ..6-O-methyl-2-deprenylrheediaxanthone B (1) and vieillardixanthone (2), were isolated from the stem bark of Garcinia vieillardii, as were four known compounds (4-7)...
  90. ncbi Caged-triprenylated and -tetraprenylated xanthones from the latex of Garcinia scortechinii
    Vatcharin Rukachaisirikul
    Department of Chemistry, Faculty of Science, Prince of Songkla University, Songkhla, 90112, Thailand
    J Nat Prod 66:933-8. 2003
    The latex of Garcinia scortechinii has yielded eight new caged-polyprenylated xanthones: two triprenylated (1 and 2) and five tetraprenylated xanthones (3-7) and one degraded caged-tetraprenylated xanthone (8), together with the known ..
  91. ncbi Prenylated xanthones with NGF-potentiating activity from Garcinia xanthochymus
    Wisinee Chanmahasathien
    Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku University, Aoba, Aramaki, Aoba ku, Sendai 980 8578, Japan
    Phytochemistry 64:981-6. 2003
    ..1) and 1,2,6-trihydroxy-5-methoxy-7-(3-methylbut-2-enyl)xanthone (2), were isolated from the wood of Garcinia xanthochymus along with a known xanthone, 12b-hydroxy-des-D-garcigerrin A (3)...
  92. ncbi Xanthones from Garcinia smeathmannii (Oliver) and their antimicrobial activity
    Justin Komguem
    Department of Organic Chemistry, Faculty of Science, University of Yaounde I, P O Box 812, Yaounde, Cameroon
    Phytochemistry 66:1713-7. 2005
    ..6H]pyrano[3,2-b]xanthen-6-one), have been isolated from the stem bark of Garcinia smeathmannii, and their structures elucidated on the basis of 1D and 2D NMR experiments...
  93. ncbi Benzopyran, biphenyl, and tetraoxygenated xanthone derivatives from the twigs of Garcinia nigrolineata
    Vatcharin Rukachaisirikul
    Department of Chemistry, Faculty of Science, Prince of Songkla University, Songkhla, 90112, Thailand
    J Nat Prod 68:1218-21. 2005
    ..xanthones, nigrolineaxanthones T-W (4-7), were isolated from the crude methanol extract of the twigs of Garcinia nigrolineata along with 11 known xanthones...
  94. ncbi Xanthones from Garcinia parvifolia
    Y J Xu
    Department of Chemistry, National University of Singapore, 10 Kent Ridge Crescent, Singapore 119260
    J Nat Prod 64:1191-5. 2001
    Nine new xanthones, parvixanthones A-I (1-9), isolated from the dried bark of Garcinia parvifolia, were found to have a common 1,3,6,7-oxygenated pattern for their xanthone nucleus, but various oxygenated isoprenyl or geranyl substituent ..
  95. ncbi Two new xanthones from the stems of Garcinia cowa
    Jie Shen
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, People s Republic of China
    Chem Pharm Bull (Tokyo) 54:126-8. 2006
    ..3), dulxanthone A (4), 1,5,6-trihydroxy-3,7-dimethoxyxanthone (5), 1,7-dihydroxyxanthone (6), 1,3,5-trihydroxy-6-methoxyxanthone (7), 1,3,6,7-tetrahydroxyxanthone (8), from the stems of Garcinia cowa (Guttiferae).
  96. ncbi Constituents of the pericarp of Garcinia subelliptica
    Chien Chang Wu
    School of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan 807, Republic of China
    J Nat Prod 68:1125-7. 2005
    ..garcinielliptone FB (2), along with six known compounds, were isolated from the pericarp of Garcinia subelliptica...
  97. ncbi Xanthone and sesquiterpene derivatives from the fruits of Garcinia scortechinii
    Yaowapa Sukpondma
    Department of Chemistry, Faculty of Science, Prince of Songkla University, Songkhla, 90112, Thailand
    J Nat Prod 68:1010-7. 2005
    The fruits of Garcinia scortechinii afforded 10 new compounds: four caged-tetraprenylated xanthones (scortechinones Q-T, 1-4), four rearranged xanthones (scortechinones U-X, 5-8), and two sesquiterpene derivatives (scortechterpenes A, B, ..
  98. ncbi Mitochondrial destabilisation and caspase-3 activation are involved in the apoptosis of Jurkat cells induced by gaudichaudione A, a cytotoxic xanthone
    Xiaohua Wu
    Department of Pharmacology, Faculty of Medicine and Science, National University of Singapore, Singapore
    Planta Med 68:198-203. 2002
    Gaudichaudione A, a cytotoxic xanthone obtained from Garcinia gaudichaudii, displayed strong growth inhibitory effects against Jurkat human leukemic cells, parental murine leukemic P388 and P388/DOX-resistant cell lines, and exhibited ..
  99. ncbi Prenylated xanthones and tocotrienols from Garcinia virgata
    Joumaa Merza
    SONAS, UFR des Sciences Pharmaceutiques et d Ingénierie de la Santé, 16 Bd Daviers, F 49100 Angers, France
    Phytochemistry 65:2915-20. 2004
    Two xanthones, namely virgataxanthone A and B, have been isolated from the stem bark of Garcinia virgata, together with two formylated tocotrienols and the known delta-tocotrienol, griffipavixanthone and 2,6-dihydroxy-4-..
  100. ncbi A novel cytotoxic guttiferone analogue from Garcinia macrophylla from the Suriname rainforest
    Russell B Williams
    Department of Chemistry M C 0212, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA
    Planta Med 69:864-6. 2003
    Bioassay-guided fractionation of the EtOAc extract of the twigs of Garcinia macrophylla from Suriname produced the known benzophenone, guttiferone A (1), and a new guttiferone analogue, guttiferone G (2). Friedelin was also isolated...
  101. ncbi Xanthones from Garcinia cowa Roxb. latex
    W Mahabusarakam
    Department of Chemistry, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand
    Phytochemistry 66:1148-53. 2005
    Five xanthones named cowagarcinone A-E and six previously reported xanthones were isolated from the latex of Garcinia cowa Roxb. Their structures were determined on the basis of spectroscopic analysis...

Research Grants18

  1. TOTAL SYNTHESIS OF NATURAL PRODUCTS
    K Nicolaou; Fiscal Year: 2002
    ..3] sigmatropic rearrangement and a radical based ring closure to form the bicyclic skeleton. ..
  2. SYNTHESIS OF ANTICANCER AGENTS
    K C Nicolaou; Fiscal Year: 2010
    ..abstract_text> ..
  3. Investigations of botanicals on food intake, satiety, weight loss, and oxidative
    Stephen D Anton; Fiscal Year: 2013
    ..Study 1 will investigate the effects of two promising botanicals (garcinia cambogia derived hydroxycitric acid, and glucomannan) on food intake, satiety, and weight loss using a double-..
  4. Mangostin: A Dietary-Based Xanthone For Prostate Cancer Chemoprevention
    Jeremy James Johnson; Fiscal Year: 2010
    ..dietary agent, alpha-Mangostin, a non- nutrient and non-toxic natural agent present in the Mangosteen fruit (Garcinia mangostana)...
  5. Chemical Biology of Caged Garcinia Xanthones
    Emmanuel A Theodorakis; Fiscal Year: 2012
    Project Summary The caged Garcinia xanthones have unique structures, potent bioactivities and largely unexplored biological mode of action...
  6. Transcriptional Regulaton of Pro-Inflammatory Genes by Gambogic Acid
    KUMBLE SANDEEP PRABHU; Fiscal Year: 2009
    ..GA is a polyprenylated xanthone, with an ?, ?-unsaturated carbonyl group, isolated from gamboges, the resin from Garcinia morella and Garcinia hanburyi...
  7. Total Synthesis of Cytotoxic Garcinia Natural Products
    TRISTAN LAMBERT; Fiscal Year: 2005
    Many members of the Garcinia family of natural products have been shown to display significant cytotoxicity against a range of cancer cell lines...
  8. TOTAL SYNTHESIS OF AZADIRACHTIN
    K Nicolaou; Fiscal Year: 2008
    ..The proposed work is expected to impact the general areas of pharmaceutical and agricultural research, and infectious diseases in particular, through discoveries in synthetic organic chemistry and chemical biology. ..
  9. Enabling Technologies for Combinatorial Chemistry
    K Nicolaou; Fiscal Year: 2005
    ..abstract_text> ..
  10. TOTAL SYNTHESIS OF APOPTOLIDIN
    K Nicolaou; Fiscal Year: 2004
    ..The proposed work is expected to have significant impact in the area of cancer chemotherapy and should provide enabling technologies and tools for biology and medicine. ..
  11. Strengthening Botanical CAM Research: A Collaboration between CUNY and Columbia
    Edward Kennelly; Fiscal Year: 2007
    ..We anticipate that within a year after the end of the project period, several R21 or R01 botanically-related CAM applications will be submitted to NIH. ..
  12. OBESE FEMALE RESTRAINED EATERS : TWO TREATMENT OPTIONS
    Judith Stern; Fiscal Year: 2002
    ..A manual of procedures will be generated to assist others in replicating the intervention. ..
  13. Magnesium and Asthma - Clinical Trials
    Judith Stern; Fiscal Year: 2004
    ..We do not anticipate that Mg supplementation will replace conventional treatment, but may complement and decrease the need for conventional medications. ..
  14. DNA and Phytochemical Fingerprinting of Actaea Species
    Edward Kennelly; Fiscal Year: 2007
    ..Our long-range goals are to improve the quality of black cohosh dietary supplements and understand the variation in Actaea species. ..
  15. Research Network for Drug-Induced Liver Disease
    Petr Protiva; Fiscal Year: 2007
    ..The clinico-pathological database and the tissue and DNA repositories will permit us to create and test numerous hypotheses relating to the pathogenesis and pharmacogenomics of DILD. ..
  16. THE UCLA CLINICAL NUTRITION RESEARCH UNIT
    David Heber; Fiscal Year: 2006
    ..The UCLA CNRU is serving as a regional and national resource at the cutting edge of nutrition and cancer prevention research...
  17. MRI Visceral Adipose Tissue Partitioning:Advanced Models
    Steven Heymsfield; Fiscal Year: 2005
    ..Our findings could help to set new standards for VAT and adipose tissue subcompartment measurement, lower the cost of MRI body composition studies, and improve study power. ..
  18. UCLA TRAINING PROGRAM IN NUTRITION AND OBESITY
    David Heber; Fiscal Year: 2007
    ..abstract_text> ..