ruta

Summary

Summary: A plant genus of the family RUTACEAE. Members contain quinoline alkaloids.

Top Publications

  1. ncbi Effect of Ruta graveolens L. and Euphorbia peplus L. anti-inflammatory extracts on nutritional status of rats and the safety of their use
    Sahar Y Al-Okbi
    Food Sciences and Nutrition Department, National Research Centre, Dokki, Cairo, Egypt
    Indian J Exp Biol 40:45-8. 2002
  2. ncbi Anti-tumour activity of Ruta graveolens extract
    K C Preethi
    Amala Cancer Research Centre, Amala Nagar, Thrissur, Kerala 680555, India
    Asian Pac J Cancer Prev 7:439-43. 2006
  3. ncbi Inhibition of lipopolysaccharide-inducible nitric oxide synthase and IL-1beta through suppression of NF-kappaB activation by 3-(1'-1'-dimethyl-allyl)-6-hydroxy-7-methoxy-coumarin isolated from Ruta graveolens L
    Sunil Kumar Raghav
    Proteomics and Structural Biology Division, Institute of Genomics and Integrative Biology, Delhi University Campus, Mall Road, Delhi 110 007, India
    Eur J Pharmacol 560:69-80. 2007
  4. ncbi Anti-inflammatory effect of Ruta graveolens L. in murine macrophage cells
    S K Raghav
    Institute of Genomics and Integrative Biology, Delhi University Campus, Mall Road, Delhi 110007, India
    J Ethnopharmacol 104:234-9. 2006
  5. ncbi Unusually divergent 4-coumarate:CoA-ligases from Ruta graveolens L
    Alexander Endler
    Institut fur Pharmazeutische Biologie, Philipps Universitat Marburg, Marburg, Germany
    Plant Mol Biol 67:335-46. 2008
  6. ncbi Methanolic extract of Ruta graveolens L. inhibits inflammation and oxidative stress in adjuvant induced model of arthritis in rats
    M Ratheesh
    Department of Biochemistry, University of Kerala, Kariavattom, Thiruvananthapuram 695581, India
    Inflammopharmacology 17:100-5. 2009
  7. ncbi Investigation of cytotoxic activity on human cancer cell lines of arborinine and furanoacridones isolated from Ruta graveolens
    Borbála Réthy
    Department of Pharmacodynamics and Biopharmacy, University of Szeged, Szeged, Hungary
    Planta Med 73:41-8. 2007
  8. ncbi A 2-oxoglutarate-dependent dioxygenase from Ruta graveolens L. exhibits p-coumaroyl CoA 2'-hydroxylase activity (C2'H): a missing step in the synthesis of umbelliferone in plants
    Guilhem Vialart
    UMR 1121 Lorraine University, INRA Agronomie et Environnement Nancy Colmar, ENSAIA, 2 Avenue de la Foret de Haye, 54505 Vandœuvre Lès Nancy, France
    Plant J 70:460-70. 2012
  9. ncbi Free phenolic acids in Ruta graveolens L. in vitro culture
    H Ekiert
    Department of Pharmaceutical Botany, Jagiellonian University, Collegium Medicum, Faculty of Pharmacy, Krakow, Poland
    Pharmazie 64:694-6. 2009
  10. ncbi Algicidal and antifungal compounds from the roots of Ruta graveolens and synthesis of their analogs
    Kumudini M Meepagala
    USDA ARS, Natural Products Utilization Research Unit, P O Box 8048, University, MS 38677, USA
    Phytochemistry 66:2689-95. 2005

Scientific Experts

Detail Information

Publications135 found, 100 shown here

  1. ncbi Effect of Ruta graveolens L. and Euphorbia peplus L. anti-inflammatory extracts on nutritional status of rats and the safety of their use
    Sahar Y Al-Okbi
    Food Sciences and Nutrition Department, National Research Centre, Dokki, Cairo, Egypt
    Indian J Exp Biol 40:45-8. 2002
    ..graveolens. The results suggest that both plant extracts have no harmful effect on nutritional status and are safe towards kidney functions, while Euphorbia is more safe than Ruta in relation to liver functions.
  2. ncbi Anti-tumour activity of Ruta graveolens extract
    K C Preethi
    Amala Cancer Research Centre, Amala Nagar, Thrissur, Kerala 680555, India
    Asian Pac J Cancer Prev 7:439-43. 2006
    An extract of Ruta graveolens was found to be cytotoxic to Dalton's lymphoma ascites (DLA), Ehrlich ascites carcinoma (EAC) and L929 cells in culture (IC100=16 mg/ml) and also to increase the lifespan of tumour bearing animals...
  3. ncbi Inhibition of lipopolysaccharide-inducible nitric oxide synthase and IL-1beta through suppression of NF-kappaB activation by 3-(1'-1'-dimethyl-allyl)-6-hydroxy-7-methoxy-coumarin isolated from Ruta graveolens L
    Sunil Kumar Raghav
    Proteomics and Structural Biology Division, Institute of Genomics and Integrative Biology, Delhi University Campus, Mall Road, Delhi 110 007, India
    Eur J Pharmacol 560:69-80. 2007
    The Ruta graveolens L. plant is used in traditional medicine to treat a large number of diseases...
  4. ncbi Anti-inflammatory effect of Ruta graveolens L. in murine macrophage cells
    S K Raghav
    Institute of Genomics and Integrative Biology, Delhi University Campus, Mall Road, Delhi 110007, India
    J Ethnopharmacol 104:234-9. 2006
    b>Ruta graveolens L. (Rutaceae) is used for several therapeutic purposes worldwide...
  5. ncbi Unusually divergent 4-coumarate:CoA-ligases from Ruta graveolens L
    Alexander Endler
    Institut fur Pharmazeutische Biologie, Philipps Universitat Marburg, Marburg, Germany
    Plant Mol Biol 67:335-46. 2008
    ..The common rue, Ruta graveolens L...
  6. ncbi Methanolic extract of Ruta graveolens L. inhibits inflammation and oxidative stress in adjuvant induced model of arthritis in rats
    M Ratheesh
    Department of Biochemistry, University of Kerala, Kariavattom, Thiruvananthapuram 695581, India
    Inflammopharmacology 17:100-5. 2009
    b>Ruta graveolens L. (Rutaceae) are traditionally used for the treatment of rheumatism, arthritis and other inflammatory conditions in the traditional medicine of India...
  7. ncbi Investigation of cytotoxic activity on human cancer cell lines of arborinine and furanoacridones isolated from Ruta graveolens
    Borbála Réthy
    Department of Pharmacodynamics and Biopharmacy, University of Szeged, Szeged, Hungary
    Planta Med 73:41-8. 2007
    The cytotoxic effects of a series of furanoacridones isolated from Ruta graveolens L...
  8. ncbi A 2-oxoglutarate-dependent dioxygenase from Ruta graveolens L. exhibits p-coumaroyl CoA 2'-hydroxylase activity (C2'H): a missing step in the synthesis of umbelliferone in plants
    Guilhem Vialart
    UMR 1121 Lorraine University, INRA Agronomie et Environnement Nancy Colmar, ENSAIA, 2 Avenue de la Foret de Haye, 54505 Vandœuvre Lès Nancy, France
    Plant J 70:460-70. 2012
    ..approach and a cDNA library screen to identify an orthologous ORF (Genbank accession number JF799117) from Ruta graveolens L...
  9. ncbi Free phenolic acids in Ruta graveolens L. in vitro culture
    H Ekiert
    Department of Pharmaceutical Botany, Jagiellonian University, Collegium Medicum, Faculty of Pharmacy, Krakow, Poland
    Pharmazie 64:694-6. 2009
    Eight phenolic acids were determined using HPLC method in methanolic extracts of Ruta graveolens L...
  10. ncbi Algicidal and antifungal compounds from the roots of Ruta graveolens and synthesis of their analogs
    Kumudini M Meepagala
    USDA ARS, Natural Products Utilization Research Unit, P O Box 8048, University, MS 38677, USA
    Phytochemistry 66:2689-95. 2005
    Bioassay-guided fractionation of the ethyl acetate extract of Ruta graveolens roots yielded rutacridone epoxide with potent selective algicidal activity towards the 2-methyl-isoborneol (MIB)-producing blue-green alga Oscillatoria ..
  11. ncbi Specific accumulation and revised structures of acridone alkaloid glucosides in the tips of transformed roots of Ruta graveolens
    Inna Kuzovkina
    Timiryazev Institute of Plant Physiology, Russian Academy of Sciences, Botanicheskaya ul 35, 127276 Moscow, Russia
    Phytochemistry 65:1095-100. 2004
    The root tips of Ruta graveolens (common rue) show strong autofluorescence of acridone alkaloids, which are characteristic secondary metabolites of this plant...
  12. pmc In silico target fishing for rationalized ligand discovery exemplified on constituents of Ruta graveolens
    Judith M Rollinger
    Institute of Pharmacy, Pharmacognosy, and Center for Molecular Biosciences, University of Innsbruck, 6020 Innsbruck, Austria
    Planta Med 75:195-204. 2009
    ..potential targets for 16 secondary metabolites isolated and identified from the aerial parts of the medicinal plant RUTA GRAVEOLENS L...
  13. ncbi Effect of Ruta graveolens L. on pregnant mice
    Tanise Gonçalves de Freitas
    Department of Morphological Sciences, Institute of Health Basic Sciences, Federal University of Rio Grande do Sul, Porto Alegre, RS90050 170, Brazil
    Contraception 71:74-7. 2005
    b>Ruta graveolens L. is used in many countries, including Brazil, as an abortifacient...
  14. ncbi Ruta graveolens aqueous extract retards mouse preimplantation embryo development
    Jorge L Gutierrez-Pajares
    Laboratorio de Reproducción y Biología del Desarrollo, Facultad de Ciencias Biologicas, Universidad Nacional Mayor de San Marcos, Lima, Peru
    Reprod Toxicol 17:667-72. 2003
    This work was undertaken to examine possible embryotoxicity of Ruta graveolens (rue), a plant used by indigenous communities for the purposes of therapeutic and fertility regulation...
  15. ncbi Phytotoxins from the leaves of Ruta graveolens
    Amber L Hale
    Department of Pharmacognosy, University of Mississippi, University, Mississippi 38677, USA
    J Agric Food Chem 52:3345-9. 2004
    Bioassay-guided fractionation of the ethyl acetate extract of Ruta graveolens (common rue) leaves led to the isolation of the furanocoumarins 5-methoxypsoralen (5-MOP), 8-methoxypsoralen (8-MOP), and the quinolone alkaloid graveoline as ..
  16. ncbi Prolongation of AV nodal refractoriness by Ruta graveolens in isolated rat hearts. Potential role as an anti-arrhythmic agent
    Vahid Khori
    Golestan Cardiovascular Research Center, Faculty of Medicine, Golestan University of Medical Sciences, Golestan, Gorgan, Iran
    Saudi Med J 29:357-63. 2008
    To evaluate concentration-dependent effects of total extract of Ruta graveolens and its purified alkaloid fraction on the nodal basic and functional properties.
  17. ncbi Natural fungicides from Ruta graveolens L. leaves, including a new quinolone alkaloid
    Anna Oliva
    Department of Life Science, Second University of Naples, Via Vivaldi 43, 81100 Naples, Italy
    J Agric Food Chem 51:890-6. 2003
    Bioassay-directed isolation of antifungal compounds from an ethyl acetate extract of Ruta graveolens leaves yielded two furanocoumarins, one quinoline alkaloid, and four quinolone alkaloids, including a novel compound, 1-methyl-2-[6'-(3' '..
  18. ncbi Antimicrobial and cytotoxic activity of Ruta graveolens
    A Ivanova
    Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, Sofia 1113, Bulgaria
    Fitoterapia 76:344-7. 2005
    The methanol, petroleum ether, ethyl acetate and water-methanol extracts of Ruta graveolens were found to possess antimicrobial and cytotoxic activities.
  19. ncbi Potential allelochemicals from the essential oil of Ruta graveolens
    Vincenzo De Feo
    Dipartimento di Scienze Farmaceutiche, Universita degli Studi di Salerno, Via Ponte Don Melillo, I 84084 Salerno, Fisciano, Italy
    Phytochemistry 61:573-8. 2002
    The essential oil of aerial parts of Ruta graveolens was obtained by hydrodistillation with a 0.74% yield on a dry weight basis. Thirty-eight components were identified by GC and GC-MS analyses...
  20. ncbi Continuity and change in the Mediterranean medical tradition: Ruta spp. (rutaceae) in Hippocratic medicine and present practices
    A Pollio
    Dipartimento delle Scienze Biologiche, Sezione di Biologia Vegetale, University Federico II of Naples, Via Foria 223, 80139 Naples, Italy
    J Ethnopharmacol 116:469-82. 2008
    b>Ruta is a genus of Rutaceae family. It features mainly shrubby plants, native to the Mediterranean region and present in traditional medicine of this region since Antiquity. The three most diffused species Ruta chalepensis L...
  21. ncbi Cinnamic acid 4-hydroxylase mechanism-based inactivation by psoralen derivatives: cloning and characterization of a C4H from a psoralen producing plant-Ruta graveolens-exhibiting low sensitivity to psoralen inactivation
    Antoine Gravot
    UMR 1121 Agronomie Environnement INPL INRA, ENSAIA 2, Av de la Forêt de Haye, 54505 Vandoeuvre Les Nancy Cedex, France
    Arch Biochem Biophys 422:71-80. 2004
    Cinnamate 4-hydroxylase (C4H, EC 1.14.13.11) complete cDNA was cloned from the leaves of Ruta graveolens, a psoralen producing plant. The recombinant enzyme (classified CYP73A32) was expressed in Saccharomyces cerevisiae...
  22. ncbi Antiandrogenic activity of Ruta graveolens L in male Albino rats with emphasis on sexual and aggressive behavior
    Nabil Azar Khouri
    Department of Anatomy, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan
    Neuro Endocrinol Lett 26:823-9. 2005
    The Ruta graveolens L. is currently used by the Jordanian population systemically for its antispasmodic, diuretic, sedative, and analgesic effects and externally for its antirheumatic effect.
  23. ncbi Neuropharmacological profile of an ethanol extract of Ruta chalepensis L. in mice
    M E Gonzalez-Trujano
    Direccion de Investigaciones en Neurociencias del Instituto Nacional de Psiquiatria Ramon de la Fuente, Calz Mexico Xochimilco 101, Col Sn Lorenzo Huipulco, 14370 Mexico, D F, Mexico
    J Ethnopharmacol 106:129-35. 2006
    The effects of an ethanol extract of the aerial parts of Ruta chalepensis on the central nervous system (CNS) and LD(50) determination were studied in mice...
  24. ncbi Ruta 6 selectively induces cell death in brain cancer cells but proliferation in normal peripheral blood lymphocytes: A novel treatment for human brain cancer
    Sen Pathak
    Department of Molecular Genetics, M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Oncol 23:975-82. 2003
    ..We investigated the brain cancer cell-killing activity of a homeopathic medicine, Ruta, isolated from a plant, Ruta graveolens...
  25. ncbi Combinatorial synthesis by nature: volatile organic sulfur-containing constituents of Ruta chalepensis L
    Sina Escher
    Firmenich SA, Corporate R and D Division, P O Box 239, CH 1211 Geneva 8
    Chem Biodivers 3:943-57. 2006
    ..new natural fragrance and flavor ingredients prompted us to examine a solvent extract of sulfurous-sweaty smelling Ruta chalepensis L. (Rutaceae) plant material more closely...
  26. ncbi Phytochemical studies on Ruta chalepensis (Lam.) Lamarck
    Keriman Günaydin
    Department of Chemistry, Faculty of Liberal Arts and Sciences, Mustafa Kemal University, 31024, Hatay, Turkey
    Nat Prod Res 19:203-10. 2005
    b>Ruta chalepensis is a rich source of important secondary metabolites such as furanocoumarins and alkaloids. Besides, it is a medicinal plant and still used in traditional medicine...
  27. ncbi Inhibitory effects of Ruta graveolens L. extract on guinea pig liver aldehyde oxidase
    Saieed Pirouzpanah
    School of Health and Nutrition, Tabriz University of Medical Sciences, Iran
    Chem Pharm Bull (Tokyo) 54:9-13. 2006
    b>Ruta graveolens L. is a flavonoid-containing medicinal plant with various biological properties. In the present study, the effects of R. graveolens extract on aldehyde oxidase, a molybdenum hydroxylase, are investigated...
  28. ncbi Medicinal plant use in the Bredasdorp/Elim region of the Southern Overberg in the Western Cape Province of South Africa
    T S A Thring
    Department of Biodiversity and Conservation Biology, University of the Western Cape, Private Bag X17, Bellville 7535, South Africa
    J Ethnopharmacol 103:261-75. 2006
    ..A more structured questionnaire was used to determine which plants were most popular for particular ailments. It was found that Artemisia afra and Ruta graveolens were the most popular.
  29. ncbi Preliminary observations on experimental Ruta graveolens toxicosis in Nubian goats
    S E I el Agraa
    Department of Veterinary Medicine, Pharmacology and Toxicology, University of Khartoum, PO Box 32, Khartoum North, Sudan
    Trop Anim Health Prod 34:271-81. 2002
    We present the first reported study of Ruta graveolens toxicity in 7-8-month-old Nubian goats. Oral administration of 5 g/kg bw per day of R...
  30. ncbi Rue the herb: Ruta graveolens--associated phytophototoxicity
    Kimberly Eickhorst
    Department of Dermatology, St Luke s Roosevelt Hospital, New York, NY, USA
    Dermatitis 18:52-5. 2007
    We describe an unusual case of phytophototoxicity induced by an herbal plant, Ruta graveolens, from the Rutaceae family. This common herb, also called rue, can be found throughout rural settings in the United States...
  31. ncbi Ethnoveterinary medicines used to treat endoparasites and stomach problems in pigs and pets in British Columbia, Canada
    Cheryl Lans
    BCICS, University of Victoria, British Columbia V8W 2Y2, Canada
    Vet Parasitol 148:325-40. 2007
    ..Ranunculaceae), Juglans nigra L. (Juglandaceae), Olea europaea L. (Oleaceae) and Ruta graveolens L. (Rutaceae)). Stomach problems were treated with: Achillea millefolium L. (Asteraceae), Aloe vera (L...
  32. ncbi Comparative study of the assay of Artemia salina L. and the estimate of the medium lethal dose (LD50 value) in mice, to determine oral acute toxicity of plant extracts
    A Logarto Parra
    Drug Research and Development Center CIDEM, Biologic Research Department, Ciudad de La Habana, Cuba
    Phytomedicine 8:395-400. 2001
    ..Plantaginaceae); Plectranthus amboinicus (Lour.) Spreng. (Lamiaceae); Ruta graveolens L. (Rutaceae); Senna alata (L.) Roxb. (Fabaceae); Stachytarpheta jamaicensis (L...
  33. ncbi The ecological aspect of ethnobotany and ethnopharmacology of population in Bosnia and Herzegovina
    Sulejman S Redzić
    Center of Ecology and Natural Resources, Faculty of Science University of Sarajevo, Sarajevo, Bosnia and Herzegovina
    Coll Antropol 31:869-90. 2007
    ..asclepiadea, Helichrysum italicum, Lycopodium clavatum, Marrubium vulgare, Nepeta cataria, Populus tremula, Ruta graveolens, Tamus communis, Teucrium montanum, T. chamaedrys, and endemic plants Gentiana lutea subsp...
  34. ncbi Compounds from Ageratum conyzoides: isolation, structural elucidation and insecticidal activity
    Márcio D Moreira
    Departamento de Biologia Animal, Universidade Federal de Vicosa, Vicosa, MG 36571 000, Brazil
    Pest Manag Sci 63:615-21. 2007
    ..Coleoptera: Bostrichidae). The plant species used were: basil (Ocimum selloi Benth.), rue (Ruta graveolens L.), lion's ear (Leonotis nepetaefolia L.), Jimson weed (Datura stramonium L...
  35. ncbi An acridone-producing novel multifunctional type III polyketide synthase from Huperzia serrata
    Kiyofumi Wanibuchi
    School of Pharmaceutical Sciences and the COE 21 Program, University of Shizuoka, Japan
    FEBS J 274:1073-82. 2007
    ..Interestingly, Hu. serrata polyketide synthase 1 lacks most of the consensus active site sequences with acridone synthase from Ruta graveolens (Rutaceae).
  36. ncbi Effects of ephedrine and phenylephrine on uterine and placental circulations and fetal outcome following fetal hypoxaemia and epidural-induced hypotension in a sheep model
    T Erkinaro
    Department of Anaesthesiology, University Hospital of Oulu, PO Box 21, FIN 90029 OYS, Finland
    Br J Anaesth 93:825-32. 2004
    ..We hypothesized that ephedrine and phenylephrine, administered for maternal hypotension following fetal hypoxaemia, are equal in respect of fetal outcome...
  37. ncbi Phylogenetic relationships of Ruteae (Rutaceae): new evidence from the chloroplast genome and comparisons with non-molecular data
    Gabriele Salvo
    Institute of Systematic Botany, University of Zurich, Zollikerstrasse 107, Ch 8008 Zurich, Switzerland
    Mol Phylogenet Evol 49:736-48. 2008
    ..The phylogenetic analyses determined that Haplophyllum and Ruta form reciprocally exclusive monophyletic groups and that Dictamnus is not closely related to the other genera of ..
  38. ncbi Evaluation of antileishmanial, cytotoxic and antioxidant activities of essential oils extracted from plants issued from the leishmaniasis-endemic region of Sned (Tunisia)
    S Ben Hadj Ahmed
    Departement de Biologie, Faculté des Sciences de Gafsa, Campus Universitaire Zarroug Gafsa 2112, Gafsa, Tunisia
    Nat Prod Res 25:1195-201. 2011
    ..62% and camphor at 13.82%) is significantly active against both L. major and L. infantum, whereas Ruta chalepensis EO (rich on 2-undecanone at 84.28%) is only active against L. infantum...
  39. ncbi Molluscicidal activity of some Moroccan medicinal plants
    M Hmamouchi
    Unité de recherche Substances Naturelles, Faculte de Medecine et de Pharmacie, Rabat, B P 6203, Rabat Institut, Maroc
    Fitoterapia 71:308-14. 2000
    ..activity, ethyl acetate extract from Origanum compactum and hexane extracts from both Chenopodium ambrosioides and Ruta chalepensis were the most active (LC(90)=2.00, 2.23 and 2...
  40. ncbi Transvaginal Doppler-guided uterine artery occlusion for the treatment of symptomatic fibroids: summary results from two pilot studies
    George A Vilos
    Department of Obstetrics and Gynecology, St Joseph s Health Care, London, ON
    J Obstet Gynaecol Can 32:149-54. 2010
    ..To evaluate the feasibility, safety, and short-term efficacy of bilateral uterine artery occlusion, using a transvaginal Doppler-guided vascular clamp as a minimally invasive therapy for symptomatic uterine leiomyomas...
  41. ncbi [Toxic hepatitis due to the use of Ruta herbal medicine]
    Elena Rabaev
    Department of Family Medicine, Dimona Dalet Clalit Health Services, Beer Sheba, Israel
    Harefuah 150:235-6, 305. 2011
    ..In this case report, we present an example of toxic hepatitis due to use of Ruta herbal medicine, an unfamiliar side effect of the common herbal medicine Ruta.
  42. ncbi Purification and properties of acridone synthase from cell suspension cultures of Ruta graveolens L
    A Baumert
    , Halle Saale, Bundesrepublik Deutschland
    Z Naturforsch C 49:26-32. 1994
    Acridone synthase has been purified from cell suspension cultures of Ruta graveolens using a combination of gel filtration and ion exchange chromatography...
  43. pmc Ruta graveolens L. toxicity in Vampirolepis nana infected mice
    R B Freire
    Department of Environmental Technology, Universidade tecnológica Federal do Paraná, Campus Medianeira, Avenida Brasil 4232, Medianeira, PR, 85884000, Brazil
    Indian J Pharmacol 42:345-50. 2010
    To determine possible toxic effects of Ruta graveolens hydroalcoholic extract in gastrointestinal parasitic infection.
  44. ncbi Oxidative profile in patients with colon cancer: effects of Ruta chalepensis L
    R Acquaviva
    Department of Biochemistry, Medical Chemistry and Molecular Biology, University of Catania, Catania, Italy
    Eur Rev Med Pharmacol Sci 15:181-91. 2011
    To verify the involvement of free radicals in tumor progression and to investigate the effects of an ethanolic extract of Ruta Chalepensis L. and of rutin in blood of patients with colon cancer.
  45. ncbi Deletion analysis of the Escherichia coli rho-dependent transcription terminator trp t'
    F Zalatan
    Department of Biology, University of Rochester, New York 14642
    J Biol Chem 268:17051-6. 1993
    ..that together appear to be important for full transcription termination efficiency in vitro and are similar to the rutA and rutB sequence elements in the lambda tR1 rho-dependent terminator previously described by Chen and Richardson (..
  46. ncbi Inhibition of chemically induced carcinogenesis by drugs used in homeopathic medicine
    K B Hari Kumar
    Amala Cancer Research Centre, Amala Nagar, Thrissur, Kerala State, India
    Asian Pac J Cancer Prev 8:98-102. 2007
    ..We have used Ruta, Hydrastis, Lycopodium and Thuja, which are commonly employed in homeopathy for treating cancer...
  47. ncbi Herbal infusions used for induced abortion
    Carmen Ciganda
    Toxicology Department, Clinical Hospital, Faculty of Medicine, Montevideo, Uruguay
    J Toxicol Clin Toxicol 41:235-9. 2003
    ..The species most frequently involved were ruda (Ruta chalepensis/graveolens), cola de quirquincho (Lycopodium saururus), parsley (Petroselinum hortense), and an over-..
  48. ncbi 'Translation is not enough': using the Global Person Generated Index (GPGI) to assess individual quality of life in Bangladesh, Thailand, and Ethiopia
    Laura Camfield
    Wellbeing in Developing Countries ESRC Research Group, University of Bath, Bath BA2 7AY, UK
    Qual Life Res 16:1039-51. 2007
    ..The GPGI is based on the widely used Patient Generated Index (Ruta, Camfield, & Martin, (2004) Quality of Life Research, 13, 1545...
  49. ncbi Blood flow to the scarred gravid uterus at 22-24 weeks of gestation
    K Flo
    Women s Health and Perinatology Research Group, Department of Clinical Medicine, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway Department of Obstetrics and Gynaecology, University Hospital of North Norway, Tromsø, Norway
    BJOG 121:210-5. 2014
    ....
  50. ncbi A coumarin-specific prenyltransferase catalyzes the crucial biosynthetic reaction for furanocoumarin formation in parsley
    Fazeelat Karamat
    Laboratoire Agronomie et Environnement Nancy Colmar, UMR 1121, Université de Lorraine, 2 Avenue de la Forêt de Haye TSA 40602, 54518, Vandoeuvre les Nancy, France Laboratoire Agronomie et Environnement Nancy Colmar, UMR 1121, INRA, 2 Avenue de la Forêt de Haye TSA 40602, 54518, Vandoeuvre les Nancy, France
    Plant J 77:627-38. 2014
    ..Introduction of this PcPT into the coumarin-producing plant Ruta graveolens showed increased consumption of endogenous umbelliferone...
  51. ncbi Clastogenic potential of Ruta graveolens extract and a homeopathic preparation in mouse bone marrow cells
    Korengath C Preethi
    Department of Biochemistry, Amala Cancer Research Centre, Kerala, India
    Asian Pac J Cancer Prev 9:763-9. 2008
    b>Ruta graveolens belonging to family Rutaceae has long been traditionally used as a medicinal plant as well as a flavoring agent in food. However, very little data are available on the toxicity of the plant...
  52. ncbi Monodimensional (GC-FID and GC-MS) and comprehensive two-dimensional gas chromatography for the assessment of volatiles and fatty acids from Ruta chalepensis aerial parts
    Laura Tedone
    Dipartimento di Scienze del Farmaco e dei Prodotti per la Salute, Universita degli Studi di Messina, Viale Annunziata, 98168, Messina, Italy
    Phytochem Anal 25:468-75. 2014
    b>Ruta chalepensis L. (Rutaceae) is widespread in the Mediterranean area. This plant has a solid tradition in ethnomedicine because of its various biological activities. Based on previous reports, the main volatile constituents of R...
  53. ncbi Anti-Trypanosoma cruzi activity of 10 medicinal plants used in northeast Mexico
    Zinnia Judith Molina-Garza
    Universidad Autonoma de Nuevo Leon, UANL, Facultad de Ciencias Biologicas, Laboratorio de Patología Molecular, Ave Universidad s n, Cd Universitaria, 66451 San Nicolás de los Garza, NL, Mexico
    Acta Trop 136:14-8. 2014
    ..citratus, Eryngium heterophyllum, Haematoxylum brasiletto, Lippia graveolens, Marrubium vulgare, Persea americana, Ruta chalepensis and Schinus molle...
  54. pmc 4-Phenoxybutoxy-substituted heterocycles--a structure-activity relationship study of blockers of the lymphocyte potassium channel Kv1.3
    Silke B Bodendiek
    Department of Pharmacology, University of California, Davis, Genome and Biomedical Sciences Facility, 451 Health Sciences Drive, Davis, CA 95616, USA
    Eur J Med Chem 44:1838-52. 2009
    ..Using 5-methoxypsoralen (5-MOP, 1), a compound isolated from Ruta graveolens, as a template we previously synthesized 5-(4-phenoxybutoxy)psoralen (PAP-1, 2) which inhibits Kv1...
  55. ncbi Optimal management of a multispecies shorebird flyway under sea-level rise
    Takuya Iwamura
    Department of Biology and Department of Environmental Earth System Science, 473 Via Ortega, Stanford University, Stanford, CA 94305, U S A Australian Research Council Centre of Excellence for Environmental Decisions, School of Biological Sciences, The University of Queensland, St Lucia, Queensland, 4072, Australia
    Conserv Biol 28:1710-20. 2014
    ..With the rapid ongoing loss of coastal wetlands globally, our method provides insight into efficient conservation planning for migratory species...
  56. ncbi Antinociceptive, anti-inflammatory and antipyretic activities of the leaf methanol extract of Ruta graveolens L. (Rutaceae) in mice and rats
    Firdows Loonat
    Discipline of Pharmacology, School of Pharmacy, University of the Western Cape, Private Bag X17, Bellville 7535, South Africa
    Afr J Tradit Complement Altern Med 11:173-81. 2014
    b>Ruta graveolens has been used to treat toothache, earache, rheumatism and fever with little scientific evidence corroborating these uses.
  57. ncbi The role of NO and cGMP in antispasmodic activity of Ruta chalepensis leaf extract on rat ileum
    A A Moazedi
    Department of Biology, School of Science, Shahid Chamran University, Ahwaz, Iran
    Pak J Biol Sci 13:83-7. 2010
    The aim of present study was to investigate the effect of hydroalcoholic extract of Ruta chalepensis (Rutaceae) leaves on rat ileum contractility and possible mechanism(s) involved...
  58. ncbi Long-term outcome from uterine fibroid embolization with tris-acryl gelatin microspheres: results of a multicenter study
    James B Spies
    Department of Radiology, Georgetown University Hospital, 3800 Reservoir Rd NW, CG 201, Washington, DC 20007 2197, USA
    J Vasc Interv Radiol 18:203-7. 2007
    ..To determine the long-term outcome of uterine fibroid therapy (UFE) using tris-acryl gelatin microspheres (TAGM)...
  59. ncbi Chemical constituents of Asplenium ruta-muraria L
    Peihong Fan
    Department of Natural Product Chemistry, School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China
    Nat Prod Res 26:1413-8. 2012
    A phytochemical study of Asplenium ruta-muraria L...
  60. pmc A previously undescribed pathway for pyrimidine catabolism
    Kevin D Loh
    Department of Plant and Microbial Biology, 111 Koshland Hall, University of California, Berkeley, CA 94720 3102, USA
    Proc Natl Acad Sci U S A 103:5114-9. 2006
    ..We propose that the genes of this operon be named rutA-G for pyrimidine utilization...
  61. ncbi From traditional European medicine to discovery of new drug candidates for the treatment of dementia and Alzheimer's disease: acetylcholinesterase inhibitors
    P Russo
    Laboratory of Systems Approaches and Non Communicable Diseases, IRCCS San Raffaele Pisana, Via di Valcannuta, 247, I 00166 Roma, Italia
    Curr Med Chem 20:976-83. 2013
    ..Starting from Galanthamine, properties of Melissa species, Salvia officinalis, Arnica chamissonis and Ruta graveolens are discussed to point to the role of these plants as potential sources for the development of ..
  62. ncbi In vitro susceptibility of Entamoeba histolytica and Giardia lamblia to plants used in Mexican traditional medicine for the treatment of gastrointestinal disorders
    Fernando Calzada
    Unidad de Investigación Médica en Farmacología de Productos Naturales, Hospital de Pediatria, 2 Piso, Centro Medico Nacional Siglo XXI, IMSS, Av Cuauhtemoc 330, Col Doctores, CP 06725, Mexico, DF, Mexico
    J Ethnopharmacol 108:367-70. 2006
    ..Dorstenia contrajerva, Senna villosa and Ruta chalepensis were the most active toward Giardia lamblia with IC50 < 38 microg/ml...
  63. ncbi Inhibition of hepatitis C virus replication by chalepin and pseudane IX isolated from Ruta angustifolia leaves
    Tutik Sri Wahyuni
    Division of Microbiology, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan Department of Pharmacognocy and Phytochemistry, Faculty of Pharmacy, Airlangga University, Jl Dharmawangsa Dalam, Surabaya 60286, Indonesia
    Fitoterapia 99:276-83. 2014
    ..In this study, we examined extracts, their subfractions and isolated compounds of Ruta angustifolia leaves for antiviral activities against HCV in cell culture...
  64. pmc Plant ethnoveterinary practices in two pyrenean territories of catalonia (iberian peninsula) and in two areas of the balearic islands and comparison with ethnobotanical uses in human medicine
    Esperança Carrió
    Laboratori de Botànica, Facultat de Farmacia, Universitat de Barcelona, Av Joan XXIII s n, 08028 Barcelona, Catalonia, Spain
    Evid Based Complement Alternat Med 2012:896295. 2012
    ..officinalis (15), Ranunculus parnassifolius (14), Meum athamanticum (13), Olea europaea (13), Quercus ilex (12), Ruta chalepensis (12), Sambucus nigra (10) and Thymus vulgaris (10)...
  65. ncbi Repellent activity of plant-derived compounds against Amblyomma cajennense (Acari: Ixodidae) nymphs
    Sara Fernandes Soares
    Centro de Parasitologia Veterinária, Escola de Veterinaria, Universidade Federal de Goias UFG, Campus II Samambaia, Caixa Postal 131, 74001 970 Goiania, GO, Brazil
    Vet Parasitol 167:67-73. 2010
    ..Cymbopogon nardus, Spiranthera odoratissima, Chenopodium ambrosioides, Ageratum conyzoides, Mentha pulegium, Ruta graveolens, and Memora nodosa were studied. Among these the extract of C...
  66. ncbi Iron deficiency and fatigue in adolescent females with heavy menstrual bleeding
    W Wang
    College of Medicine, The Ohio State University, Columbus, OH, USA
    Haemophilia 19:225-30. 2013
    ..To evaluate the degree and effects of menstrual blood loss, we utilized the Ruta Menorrhagia Severity Score. We investigated the symptoms of fatigue using the Fatigue Severity Scale...
  67. ncbi Composition and anti-oxidant, anti-cancer and anti-inflammatory activities of Artemisia herba-alba, Ruta chalpensis L. and Peganum harmala L
    Daycem Khlifi
    Universite de Toulouse, Laboratoire des Interactions Moleculaires et Reactivite Chimique et Photochimique, UMR CNRS 5623, Universite Paul Sabatier, 118 route de Narbonne, F 31062 Toulouse, France
    Food Chem Toxicol 55:202-8. 2013
    In this study, biological activities of methanolic extracts from Artemisia herba-alba, Ruta chalpensis L. and Peganum harmala L. plants, collected in Centre of Tunisia, were investigated...
  68. ncbi An improved assay for the detection of alterations in bacterial DNA supercoiling in vivo
    M Abu Mraheil
    Pharmaceutical Biology and Microbiology, University of Hamburg, Germany
    Pharmazie 68:541-8. 2013
    ....
  69. ncbi Bioactivity against Bursaphelenchus xylophilus: Nematotoxics from essential oils, essential oils fractions and decoction waters
    Jorge M S Faria
    Universidade de Lisboa, Faculdade de Ciencias de Lisboa, DBV, IBB, Centro de Biotecnologia Vegetal, C2, Campo Grande, 1749 016 Lisboa, Portugal
    Phytochemistry 94:220-8. 2013
    ..Twenty EOs showed corrected mortalities ⩾96% at 2 μL/mL. These were further tested at lower concentrations. Ruta graveolens, Satureja montana and Thymbra capitata EOs showed lethal concentrations (LC100)<0.4μL/mL...
  70. ncbi [Transformation of the names of certain herbs by linguistic transfer - colchicum, wormseed, soybean, nandina and wijnruit]
    Masao Uchibayashi
    Yakushigaku Zasshi 39:350-4. 2004
    ..and soybeans, (4) from the Japanese plant nanten to the genus Nandina, and (5) from the Dutch term wijnruit (wine-ruta) to hen-ruda in Japanese...
  71. ncbi Field trials on the repellent activity of four plant products against mainly Mansonia population in western Ethiopia
    Mamuye Hadis
    Ethiopian Health and Nutrition Research Institute, PO Box 1242, Addis Ababa, Ethiopia
    Phytother Res 17:202-5. 2003
    The repellent activity of essential oils of lemon eucalyptus (Eucalyptus maculata citrodion), rue (Ruta chalepensis), oleoresin of pyrethrum (Chrysanthemum cinerariaefolium) and neem (Azadiracta indica) have been field tested as 40%, 50% ..
  72. ncbi Furanocoumarin biosynthesis in Ammi majus L. Cloning of bergaptol O-methyltransferase
    Marc Hehmann
    Institut fur Pharmazeutische Biologie, Philipps Universitat Marburg, Germany
    Eur J Biochem 271:932-40. 2004
    ..had been reported to methylate bergaptol to bergapten and xanthotoxol to xanthotoxin, from induced cell cultures of Ruta graveolens, Petroselinum crispum and Ammi majus...
  73. ncbi Furanocoumarins: novel topoisomerase I inhibitors from Ruta graveolens L
    Renuka Diwan
    Department of Botany, University of Pune, Pune 411007, Maharashtra, India
    Bioorg Med Chem 17:7052-5. 2009
    Topoisomerase I inhibitors from Ruta graveolens are reported for the first time. Potent topoisomerase I inhibitory activity from in vitro culture extracts R. graveolens were observed...
  74. ncbi Evaluating companion planting and non-host masking odors for protecting roses from the Japanese beetle (Coleoptera: Scarabaeidae)
    D W Held
    Department of Entomology, University of Kentucky, Lexington, KY 40546 0091, USA
    J Econ Entomol 96:81-7. 2003
    ..Three reputedly effective companion species, rue (Ruta graveolens L.), zonal geranium (Pelargonium x hortorum Bailey), and garlic chives (Allium scheonparum L...
  75. ncbi Perinatal toxicology of Ruta chalepensis (Rutaceae) in mice
    R Zeichen de Sa
    Departamento de Farmacologia, Instituto Nacional de Medicamentos, Administración Nacional de Medicamentos, Alimentos y Tecnología Médica, Buenos Aires, Argentina
    J Ethnopharmacol 69:93-8. 2000
    Dried leaf infusions of Ruta chalepensis L. (Rutaceae), 'rue', 'ruda', were found to cause perinatal changes in mice, at daily doses of 0.16, 0.80 and 1.60 g/kg, administered p.o. from 1 to 14 days post coitum...
  76. ncbi Oral administration of alkaloid fraction from Ruta graveolens inhibits oxidative stress and inflammation in hypercholesterolemic rabbits
    M Ratheesh
    Department of Biochemistry, University of Kerala, Thiruvananthapuram, India
    Pharm Biol 51:1552-8. 2013
    The anti-atherogenic effect of alkaloid fraction from Ruta graveolens Linn (Rutaceae) extract is suspected to be related to its activities of antioxidation and anti-inflammation.
  77. ncbi Induction of apoptosis of tumor cells by some potentiated homeopathic drugs: implications on mechanism of action
    Korengath Preethi
    Amala Cancer Research Centre, Thrissur, Kerala, India
    Integr Cancer Ther 11:172-82. 2012
    ..Earlier studies indicated that homoeopathic medicines are cytotoxic to tumor cells and reduced animal tumors. However, the mechanism of homoeopathic medicines at the cellular level is not known...
  78. pmc CYP98A22, a phenolic ester 3'-hydroxylase specialized in the synthesis of chlorogenic acid, as a new tool for enhancing the furanocoumarin concentration in Ruta graveolens
    Fazeelat Karamat
    Université de Lorraine UMR 1121, Agronomie et Environnement Nancy Colmar, ENSAIA 2 avenue de la forêt de Haye, 54505 Vandœuvre Lès Nancy, France
    BMC Plant Biol 12:152. 2012
    ..with proven therapeutic properties and are produced in only a small number of medicinal plant species such as Ruta graveolens. In vivo, these molecules play a protective role against phytophageous insect attack...
  79. ncbi Chemical composition and antimicrobial activity of the essential oils from four Ruta species growing in Algeria
    Farah Haddouchi
    Laboratory of Natural Products, Department of Biology, Faculty of Sciences, Abou Bekr Belkaid University, B P 119, Tlemcen 13000, Algeria
    Food Chem 141:253-8. 2013
    ..of this research is to study the antibacterial and antifungal effects of four traditional plants essential oils, Ruta angustifolia, Ruta chalepensis, Ruta graveolens and Ruta tuberculata, against standard bacterial and fungal strains...
  80. ncbi Effect of polyamines on shoot multiplication and furanocoumarin production in Ruta graveolens cultures
    Renuka Diwan
    Department of Botany, University of Pune, India
    Nat Prod Commun 7:895-8. 2012
    ..furanocoumarin production was investigated by exogenous addition, at different concentrations, to shoot cultures of Ruta graveolens at different phases of growth...
  81. ncbi Anti-inflammatory effect of quinoline alkaloid skimmianine isolated from Ruta graveolens L
    M Ratheesh
    Department of Biochemistry, Kerala University, Trivandrum, India
    Inflamm Res 62:367-76. 2013
    The present study evaluates the anti-inflammatory effect of the quinoline alkaloid skimmianine (SKM), isolated from Ruta graveolens L., against carrageenan-induced acute inflammation.
  82. ncbi [Effects of ruta SSP on the activity of the smooth gastrointestinal muscle isolated of rat]
    Carlota A Grigorjev
    Cátedra de Farmacología General Escuela Práctica Facultad de Ciencias Médicas Universidad Nacional de Córdoba Santa Rosa 1085, 5000 Cordoba, Argentina
    Rev Fac Cien Med Univ Nac Cordoba 67:77-80. 2010
    b>Ruta graveolens L. and Ruta chalepensis L. are plants used in folkloric medicine as antispasmodics, digestive and for intestinal gases...
  83. ncbi Unusual pseudosubstrate specificity of a novel 3,5-dimethoxyphenol O-methyltransferase cloned from Ruta graveolens L
    Laura Burga
    Institut fur Pharmazeutische Biologie, Philipps Universitat Marburg, Deutschhausstrasse 17A, D 35037 Marburg, Germany
    Arch Biochem Biophys 440:54-64. 2005
    A cDNA was cloned from Ruta graveolens cells encoding a novel O-methyltransferase (OMT) with high similarity to orcinol or chavicol/eugenol OMTs, but containing a serine-rich N-terminus and a 13 amino acid insertion between motifs IV and ..
  84. ncbi Molecular authentication of the medicinal herb Ruta graveolens (Rutaceae) and an adulterant using nuclear and chloroplast DNA markers
    F Al-Qurainy
    Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, Saudi Arabia
    Genet Mol Res 10:2806-16. 2011
    ..b>Ruta graveolens, sold as a dried medicinal herb, can be adulterated with Euphorbia dracunculoides...
  85. ncbi Floral ontogeny of Ruteae (Rutaceae) and its systematic implications
    L Wei
    State Key Laboratory of Systematic and Evolutionary Botany, Institute of Botany, Chinese Academy of Sciences, Xiangshan, Beijing, China
    Plant Biol (Stuttg) 14:190-7. 2012
    Floral development was investigated in Ruta graveolens and Psilopeganum sinense, representing two genera in the tribe Ruteae. Special attention was paid to the sequence of initiation of organ whorls in the androecium and gynoecium...
  86. ncbi Accumulation of biologically active furanocoumarins in agitated cultures of Ruta graveolens L. and Ruta graveolens ssp. divaricata (Tenore) Gams
    H Ekiert
    Chair and Department of Pharmaceutical Botany, Collegium Medicum, Jagiellonian University, 9 Medyczna Street, 30 688 Krakow, Poland
    Pharmazie 60:623-6. 2005
    ..xanthotoxin, isopimpinellin, imperatorin) and their biogenetic precursor, umbelliferone, in agitated cultures of Ruta graveolens L. and Ruta graveolens ssp. divaricata (Tenore) Gams during 6-week growth cycles...
  87. pmc Ruta graveolens extract induces DNA damage pathways and blocks Akt activation to inhibit cancer cell proliferation and survival
    Khalda Fadlalla
    Department of Pathobiology, Center for Cancer Research, Tuskegee, AL 36088, USA
    Anticancer Res 31:233-41. 2011
    b>Ruta graveolens is a medicinal herb that has been used for centuries against various ailments. This study examined the anticancer properties of the herb using cancer cell lines.
  88. ncbi Temporary uterine artery occlusion for treatment of menorrhagia and uterine fibroids using an incisionless Doppler-guided transvaginal clamp: case report
    G A Vilos
    Department of Obstetrics and Gynecology, University of Western Ontario, St Joseph s Health Care, London, Ontario, Canada
    Hum Reprod 21:269-71. 2006
    ..Menorrhagia symptoms were tracked with the Ruta Menorrhagia Severity Scale. Uterine and fibroid volumes were measured by analysis of magnetic resonance images...
  89. ncbi Quality of life in women with bleeding disorders
    S Von Mackensen
    Institute for Medical Psychology and Policlinics, Centre of Psychosocial Medicine, University Medical Centre of Hamburg Eppendorf, Hamburg, Germany
    Haemophilia 17:33-7. 2011
    ..instruments are available for the adequate assessment of the impact of menorrhagia on HRQOL, namely the Ruta Menorrhagia Severity Scale, the menorrhagia multi-attribute utility scale and the Menorrhagia Impact Questionnaire...
  90. ncbi Aliphatic ketones from Ruta chalepensis (Rutaceae) induce paralysis on root knot nematodes
    Nikoletta G Ntalli
    Department of Pharmaceutical Chemistry and Technology, University of Cagliari, Cagliari, Italy
    J Agric Food Chem 59:7098-103. 2011
    This paper reports on the use of Ruta chalepensis L. extracts as a potential nematicide against root knot nematodes Meloidogyne incognita and Meloidogyne javanica . The essential oil (REO) and methanol extract (RME) of R...
  91. ncbi Evaluation of antimicrobial activity of selected plant extracts by rapid XTT colorimetry and bacterial enumeration
    Amal G Al-Bakri
    Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, University of Jordan, Amman 11942, Jordan
    J Microbiol Methods 68:19-25. 2007
    ..The plant extracts of Hypericum triquetrifolium, Ballota undulata, Ruta chalepensis, Ononis natrix, Paronychia argentea and Marrubium vulgare had shown promising antimicrobial activity...
  92. ncbi Mutagenicity testing of rutacridone epoxide and rutacridone, alkaloids in Ruta graveolens L., using the Salmonella/microsome assay
    H Paulini
    Institut fúr Botanik und Pharmazeutische Biologie der Universität Erlangen Nürnberg, FRG
    Mutagenesis 4:45-50. 1989
    ..Evidence is presented that rutacridone is metabolized by rat liver enzymes to the corresponding epoxide as the ultimate mutagen...
  93. ncbi Tracing the temporal and spatial origins of island endemics in the Mediterranean region: a case study from the citrus family (Ruta L., Rutaceae)
    Gabriele Salvo
    Institute of Systematic Botany, University of Zurich, Zurich, Switzerland
    Syst Biol 59:705-22. 2010
    ..including the Mediterranean basin and Macaronesia) provides the geographic backdrop for the diversification of Ruta L., the type genus of Rutaceae (citrus family)...
  94. ncbi High-resolution gas-chromatographic analysis of the secondary metabolites obtained by subcritical-fluid extraction from Colombian rue (Ruta graveolens L.)
    E E Stashenko
    Phytochemistry and Chromatography Laboratory, School of Chemistry, Industrial University of Santander, A A 678, Bucaramanga, Colombia
    J Biochem Biophys Methods 43:379-90. 2000
    ..Extractor, was used to isolate secondary metabolites from leaves, flowers, stems and roots of Colombian rue (Ruta graveolens L.)...
  95. ncbi Intracranial cysticercosis: an effective treatment with alternative medicines
    P Banerji
    PBH Research Foundation, 10 3 1 Elgin Road, Calcutta 700 020, West Bengal, India
    In Vivo 15:181-4. 2001
    The purpose of this study was to demonstrate the cysticidal activities of Ruta graveolens and calcium phosphate in fractional dilutions as a completely new approach for the treatment of neurocysticercosis in humans...
  96. ncbi Water-soluble glycosides from Ruta graveolens
    C C Chen
    National Research Institute of Chinese Medicine, NO 155 1, Sec 2, Li Nung Street, Peitou, Taipei, Taiwan, Republic of China
    J Nat Prod 64:990-2. 2001
    An EtOH extract of the dried aerial parts of Ruta graveolens was suspended in water and then partitioned with EtOAc...
  97. ncbi Biological effects of rutin on the survival of Escherichia coli AB1157 and on the electrophoretic mobility of plasmid PUC 9.1 DNA
    Luciana C Bernardo
    Universidade do Estado do Rio de Janeiro, Instituto de Biologia Roberto Alcantara Gomes, Departamento de Biofisica e Biometria, RJ, Brazil
    Cell Mol Biol (Noisy-le-grand) 48:517-20. 2002
    The use of natural products as medicines is growing in the world. The rutin, a compound isolated from Ruta graveolens, is a flavonoid, which has been suggested to have antioxidant properties and to reduce the triacylglycerol levels...
  98. ncbi A new dicoumarinyl ether and two rare furocoumarins from Ruta montana
    Z Kabouche
    Université Mentouri Constantine, Faculte des Sciences, Laboratoire d Obtention de Substances Thérapeutiques L O S T, Campus Chaabet Ersas, Constantine 25000, Algerie
    Fitoterapia 74:194-6. 2003
    A new dicoumarinyl ether, rutamontine and two rare furocoumarins, heraclenol and isopimpinellin, were isolated from Ruta montana...
  99. ncbi Accumulation of biologically active furanocoumarins in Ruta graveolens ssp. divaricata (Tenore) Gams in vitro culture
    H Ekiert
    Department of Pharmaceutical Botany, Collegium Medicum, Jagiellonian University, Krakow, Poland
    Pharmazie 60:66-8. 2005
    ..dynamics of accumulation of five linear furanocoumarins and umbelliferone in stationary liquid cultures of Ruta graveolens ssp. divaricata (Tenore) Gams during 6-week growth cycles...
  100. ncbi Conjugate additions of o-iodoanilines and methyl anthranilates to acetylenic sulfones. A new route to quinolones including first syntheses of two alkaloids from the medicinal herb Ruta chalepensis
    Thomas G Back
    Department of Chemistry, University of Calgary, Calgary, Alberta, Canada T2N 1N4
    J Org Chem 68:2223-33. 2003
    ..The resulting 2-substituted 4-quinolones included the naturally occurring medicinal compounds 1 and 2 and the O-methyl derivative 3...
  101. ncbi Protection against murine endotoxemia by treatment with Ruta chalepensis L., a plant with anti-inflammatory properties
    Liliana Iauk
    Department of Microbiological and Gynaecological Sciences, Section of Microbiology, University of Catania, Via Androne 81, Catania 95124, Italy
    J Ethnopharmacol 90:267-72. 2004
    The anti-inflammatory effect of the extract of Ruta Chalepensis L. (Rutaceae) on the course of lethal endotoxemia in BALB/c mice was studied. When administered by gavage as 1 g/kg per day starting 14 or 7 days prior to injection of 0...

Research Grants3

  1. GENETIC STUDIES OF GLUTAMINE SYNTHETASE IN BACTERIA
    SYDNEY GOVONS KUSTU; Fiscal Year: 2010
    ..and biochemical approaches to identify the intermediates of the Rut pathway and the enzymatic activities of the RutA-RutF proteins. We will study the DNA binding and transcriptional repression activities of RutR in vitro...
  2. Small Molecule Kv1.3 Blockers as New Therapeutics for Multiple Sclerosis
    Heike Wulff; Fiscal Year: 2007
    ..Following up on anecdotal reports from the late 1980s that tea prepared from Ruta graveolens, the common rue, had beneficial effects in MS, we discovered that Ruta contained a small molecule called ..
  3. Structural Analysis of Voltage-gated Potassium Channels
    ROBERT BLAUSTEIN; Fiscal Year: 2006
    ..abstract_text> ..