punicaceae

Summary

Summary: A plant family of the order Myrtales, subclass Rosidae, class Magnoliopsida that is a small family with a single genus.

Top Publications

  1. ncbi Therapeutic applications of pomegranate (Punica granatum L.): a review
    Julie S Jurenka
    Thorne Research, PO Box 25, Dover, ID 83825, USA
    Altern Med Rev 13:128-44. 2008
  2. ncbi In vitro antiproliferative, apoptotic and antioxidant activities of punicalagin, ellagic acid and a total pomegranate tannin extract are enhanced in combination with other polyphenols as found in pomegranate juice
    Navindra P Seeram
    Center for Human Nutrition, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    J Nutr Biochem 16:360-7. 2005
  3. ncbi Antioxidant activity of Punica granatum fruits
    D Ricci
    Istituto di Botanica e Orto Botanico Pierina Scaramella, Via Bramante 28, Facoltà di Farmacia Università degli Studi di Urbino 61029, Urbino, Italy
    Fitoterapia 77:310-2. 2006
  4. ncbi Pomegranate extract improves a depressive state and bone properties in menopausal syndrome model ovariectomized mice
    Junko Mori-Okamoto
    School of Health and Social Services, Saitama Prefectural University, Saitama 343 8540, Japan
    J Ethnopharmacol 92:93-101. 2004
  5. ncbi Anti-oxidative effects of pomegranate juice (PJ) consumption by diabetic patients on serum and on macrophages
    Mira Rosenblat
    The Lipid Research Laboratory, Technion Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciences, Rambam Medical Center, 31096 Haifa, Israel
    Atherosclerosis 187:363-71. 2006
  6. ncbi Punica granatum: heuristic treatment for diabetes mellitus
    Sarah Rachel Katz
    Rimonest Ltd, Haifa, Israel
    J Med Food 10:213-7. 2007
  7. ncbi Antimicrobial activity of pomegranate (Punica granatum L.) fruit peels
    N S Al-Zoreky
    Department of Food Science and Nutrition, College of Agricultural and Food Sciences, P O Box 420, King Faisal University, Al Ahsa 31982, Saudi Arabia
    Int J Food Microbiol 134:244-8. 2009
  8. ncbi Synergic interaction between pomegranate extract and antibiotics against Staphylococcus aureus
    L C Braga
    Departamento de Biologia Geral, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Brazil
    Can J Microbiol 51:541-7. 2005
  9. ncbi Anti-diabetic action of Punica granatum flower extract: activation of PPAR-gamma and identification of an active component
    Tom H W Huang
    Herbal Medicines Research and Education Centre, The University of Sydney, NSW 2006 Australia
    Toxicol Appl Pharmacol 207:160-9. 2005
  10. ncbi Pomegranate juice, total pomegranate ellagitannins, and punicalagin suppress inflammatory cell signaling in colon cancer cells
    Lynn S Adams
    Center for Human Nutrition, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    J Agric Food Chem 54:980-5. 2006

Detail Information

Publications201 found, 100 shown here

  1. ncbi Therapeutic applications of pomegranate (Punica granatum L.): a review
    Julie S Jurenka
    Thorne Research, PO Box 25, Dover, ID 83825, USA
    Altern Med Rev 13:128-44. 2008
    ..Other potential applications include infant brain ischemia, male infertility, Alzheimer's disease, arthritis, and obesity...
  2. ncbi In vitro antiproliferative, apoptotic and antioxidant activities of punicalagin, ellagic acid and a total pomegranate tannin extract are enhanced in combination with other polyphenols as found in pomegranate juice
    Navindra P Seeram
    Center for Human Nutrition, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    J Nutr Biochem 16:360-7. 2005
    ..The superior bioactivity of PJ compared to its purified polyphenols illustrated the multifactorial effects and chemical synergy of the action of multiple compounds compared to single purified active ingredients...
  3. ncbi Antioxidant activity of Punica granatum fruits
    D Ricci
    Istituto di Botanica e Orto Botanico Pierina Scaramella, Via Bramante 28, Facoltà di Farmacia Università degli Studi di Urbino 61029, Urbino, Italy
    Fitoterapia 77:310-2. 2006
    ..Arils, juice and rinds of Punica granatum fruits and their aqueous and ethyl acetate extracts displayed good antioxidant activity...
  4. ncbi Pomegranate extract improves a depressive state and bone properties in menopausal syndrome model ovariectomized mice
    Junko Mori-Okamoto
    School of Health and Social Services, Saitama Prefectural University, Saitama 343 8540, Japan
    J Ethnopharmacol 92:93-101. 2004
    ..These changes suggest that the pomegranate extract inhibits ovariectomy-stimulated bone turnover. It is thus conceivable that pomegranate is clinically effective on a depressive state and bone loss in menopausal syndrome in women...
  5. ncbi Anti-oxidative effects of pomegranate juice (PJ) consumption by diabetic patients on serum and on macrophages
    Mira Rosenblat
    The Lipid Research Laboratory, Technion Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciences, Rambam Medical Center, 31096 Haifa, Israel
    Atherosclerosis 187:363-71. 2006
    ....
  6. ncbi Punica granatum: heuristic treatment for diabetes mellitus
    Sarah Rachel Katz
    Rimonest Ltd, Haifa, Israel
    J Med Food 10:213-7. 2007
    ..Pomegranate fractions and their active compounds hold potential and are worthy of further investigations as safe and effective medical treatments for diabetes mellitus and its pathological consequences...
  7. ncbi Antimicrobial activity of pomegranate (Punica granatum L.) fruit peels
    N S Al-Zoreky
    Department of Food Science and Nutrition, College of Agricultural and Food Sciences, P O Box 420, King Faisal University, Al Ahsa 31982, Saudi Arabia
    Int J Food Microbiol 134:244-8. 2009
    ..Phytochemical analyses revealed the presence of active inhibitors in peels, including phenolics and flavonoids. The activity of WME was related to its higher content (262.5 mg/g) of total phenolics...
  8. ncbi Synergic interaction between pomegranate extract and antibiotics against Staphylococcus aureus
    L C Braga
    Departamento de Biologia Geral, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Brazil
    Can J Microbiol 51:541-7. 2005
    ..aureus resistant to PGME was low and they did not survive. In conclusion, PGME dramatically enhanced the activity of all antibiotics tested, and thus, offers an alternative for the extension of the useful lifetime of these antibiotics...
  9. ncbi Anti-diabetic action of Punica granatum flower extract: activation of PPAR-gamma and identification of an active component
    Tom H W Huang
    Herbal Medicines Research and Education Centre, The University of Sydney, NSW 2006 Australia
    Toxicol Appl Pharmacol 207:160-9. 2005
    ..Thus, our findings indicate that PPAR-gamma is a molecular target for PGF extract and its prominent component gallic acid, and provide a better understanding of the potential mechanism of the anti-diabetic action of PGF...
  10. ncbi Pomegranate juice, total pomegranate ellagitannins, and punicalagin suppress inflammatory cell signaling in colon cancer cells
    Lynn S Adams
    Center for Human Nutrition, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    J Agric Food Chem 54:980-5. 2006
    ..Therefore, the polyphenolic phytochemicals in the pomegranate can play an important role in the modulation of inflammatory cell signaling in colon cancer cells...
  11. ncbi Absorption, metabolism, and antioxidant effects of pomegranate (Punica granatum l.) polyphenols after ingestion of a standardized extract in healthy human volunteers
    Susanne U Mertens-Talcott
    Pharmaceutics Department, University of Florida, Gainesville, Florida 32610, USA
    J Agric Food Chem 54:8956-61. 2006
    ..Overall, this study demonstrated the absorbability of EA from a pomegranate extract high in ellagitannin content and its ex vivo antioxidant effects...
  12. ncbi The potent in vitro antioxidant ellagitannins from pomegranate juice are metabolised into bioavailable but poor antioxidant hydroxy-6H-dibenzopyran-6-one derivatives by the colonic microflora of healthy humans
    Begoña Cerdá
    Research Group on Quality, Safety and Bioactivity of Plant Foods, Department Food Science and Technology, CEBAS CSIC, 164, 30100, Espinardo Murcia, Spain
    Eur J Nutr 43:205-20. 2004
    ..The most potent in vitro antioxidant polyphenol from this juice is the ellagitannin punicalagin. However, the bioavailability of ellagitannins, including punicalagin, has not been previously described in humans...
  13. ncbi Ellagitannin-rich pomegranate extract inhibits angiogenesis in prostate cancer in vitro and in vivo
    Maryam R Sartippour
    Center for Human Nutrition, Los Angeles, CA 90095 1742, USA
    Int J Oncol 32:475-80. 2008
    ..Further studies in humans are needed to confirm that angiogenesis can be inhibited by an ellagitannin-rich pomegranate extract administered orally as a dietary supplement...
  14. ncbi Pomegranate juice (PJ) consumption antioxidative properties on mouse macrophages, but not PJ beneficial effects on macrophage cholesterol and triglyceride metabolism, are mediated via PJ-induced stimulation of macrophage PON2
    Mira Rosenblat
    The Lipid Research Laboratory, Technion Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciences, Rambam Medical Center, Haifa 31096, Israel
    Atherosclerosis 212:86-92. 2010
    ..To examine whether the beneficial effects of PJ consumption by mice on their macrophages are mediated via PJ-induced increment in serum paraoxonase 1 (PON1) activity and/or in macrophage PON2 expression...
  15. ncbi Antidiabetic effect of Punica granatum flowers: effect on hyperlipidemia, pancreatic cells lipid peroxidation and antioxidant enzymes in experimental diabetes
    Priyanka Bagri
    Department of Pharmacognosy and Phytochemistry, Pharmacognosy and Pharmaceutical Research Laboratory, Faculty of Pharmacy, Jamia Hamdard Hamdard University, New Delhi 110062, India
    Food Chem Toxicol 47:50-4. 2009
    ....
  16. ncbi Antimicrobial activity of six pomegranate (Punica granatum L.) varieties and their relation to some of their pomological and phytonutrient characteristics
    Ahmet D Duman
    Department of Food Engineering, University of Kahramanmaras Sutcu Imam, Kahramanmaras, Turkey
    Molecules 14:1808-17. 2009
    ..The MIC values for active pomegranate extracts ranged between 30 and >90 microg/mL. The results obtained appeared to confirm the antimicrobial potential of the Punica granatum varieties...
  17. ncbi Pomegranate juice ellagitannin metabolites are present in human plasma and some persist in urine for up to 48 hours
    Navindra P Seeram
    Departments of Biomathematics and Human Genetics, University of California, Los Angeles, CA, USA
    J Nutr 136:2481-5. 2006
    ..Whether genetic polymorphisms in EA-metabolizing enzymes (e.g., catechol-O-methyl transferase and glucuronosyl transferase) are related to variations in response to PJ remains to be established...
  18. ncbi Prostate cancer prevention through pomegranate fruit
    Arshi Malik
    Department of Dermatology, University of Wisconsin, Madison 53706, USA
    Cell Cycle 5:371-3. 2006
    ....
  19. ncbi Pomegranate juice: a heart-healthy fruit juice
    Arpita Basu
    Department of Nutritional Sciences, 301 Human Environmental Sciences, Oklahoma State University, Stillwater, Oklahoma 74078 6141, USA
    Nutr Rev 67:49-56. 2009
    ..Thus, the potential cardioprotective benefits of pomegranate juice deserve further clinical investigation, and evidence to date suggests it may be prudent to include this fruit juice in a heart-healthy diet...
  20. pmc Pomegranate polyphenols down-regulate expression of androgen-synthesizing genes in human prostate cancer cells overexpressing the androgen receptor
    Mee Young Hong
    Center for Human Nutrition, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA
    J Nutr Biochem 19:848-55. 2008
    ....
  21. ncbi Breast cancer chemopreventive properties of pomegranate (Punica granatum) fruit extracts in a mouse mammary organ culture
    R Mehta
    Department of Surgical Oncology, College of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA
    Eur J Cancer Prev 13:345-8. 2004
    ..The results highlight enhanced breast cancer preventive potential both for the purified compound peak B and for pomegranate seed oil, both greater than that previously reported for pomegranate fermented juice polyphenols...
  22. ncbi Potent antifungal activity of extracts and pure compound isolated from pomegranate peels and synergism with fluconazole against Candida albicans
    Eliana Harue Endo
    Programa de Pós Graduação em Ciências Farmacêuticas, Universidade Estadual de Maringa, Av Colombo, 5790, 87020 900 Maringa, PR, Brazil
    Res Microbiol 161:534-40. 2010
    ....
  23. ncbi Antioxidant properties of peel and pulp hydro extract in ten Persian pomegranate cultivars
    M Hajimahmoodi
    Department of Drug and Food Control, Faculty of Pharmacy, Medical Sciences University of Tehran, Postal Box 14155 6451, Tehran, Iran
    Pak J Biol Sci 11:1600-4. 2008
    ..The peel extract of sweet white peel cultivar appeared to have more potential as a health supplement rich in natural antioxidants compared to the pulp and peel extracts of other pomegranate cultivars...
  24. ncbi In vitro activity of Brazilian medicinal plants, naturally occurring naphthoquinones and their analogues, against methicillin-resistant Staphylococcus aureus
    T B Machado
    Núleo de Pesquisas de Productos Naturais, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
    Int J Antimicrob Agents 21:279-84. 2003
    ..The results indicate that these natural products can be effective potential candidates for the development of new strategies to treat MRSA infections...
  25. ncbi Pomegranate juice decreases amyloid load and improves behavior in a mouse model of Alzheimer's disease
    Richard E Hartman
    Department of Psychology, Loma Linda University, Loma Linda, CA 92354, USA
    Neurobiol Dis 24:506-15. 2006
    ..These results suggest that further studies to validate and determine the mechanism of these effects, as well as whether substances in PJ may be useful in AD, should be considered...
  26. ncbi Chondroprotective effects of pomegranate juice on monoiodoacetate-induced osteoarthritis of the knee joint of mice
    Mahsa Hadipour-Jahromy
    Department of Pharmacology, Tehran Medical Branch, Islamic Azad University, Tehran, Iran
    Phytother Res 24:182-5. 2010
    ..No cell proliferation or inflammatory cells were detected in the synovial fluid. The effectiveness of pomegranate juice in improving histopathological damage is emphasized and its chondroprotective effect in vivo highlighted...
  27. pmc Pomegranate fruit juice for chemoprevention and chemotherapy of prostate cancer
    Arshi Malik
    Department of Dermatology, University of Wisconsin, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 102:14813-8. 2005
    ..We suggest that pomegranate juice may have cancer-chemopreventive as well as cancer-chemotherapeutic effects against prostate cancer in humans...
  28. ncbi Flavonoids from Punica granatum--potential antiperoxidative agents
    S Sudheesh
    Department of Biochemistry, University of Kerala, Thiruvananthapuram, 695581 India
    Fitoterapia 76:181-6. 2005
    ..Concentrations of glutathione in the tissues were also increased...
  29. pmc Pomegranate extract inhibits the interleukin-1β-induced activation of MKK-3, p38α-MAPK and transcription factor RUNX-2 in human osteoarthritis chondrocytes
    Zafar Rasheed
    Department of Medicine, Division of Rheumatology, MetroHealth Medical Center Case Western Reserve University, 2500 Metro Health Drive, Cleveland, OH 44109, USA
    Arthritis Res Ther 12:R195. 2010
    ..In this study we determined the effect of a standardized pomegranate extract (PE) on the IL-1β-induced activation of MKK3/6, p38-MAPK isoforms and the activation of transcription factor RUNX-2 in primary human OA chondrocytes...
  30. pmc Consumption of hydrolyzable tannins-rich pomegranate extract suppresses inflammation and joint damage in rheumatoid arthritis
    Meenakshi Shukla
    Division of Rheumatic Diseases, Department of Medicine, Case Western Reserve University University Hospitals of Cleveland, Cleveland, Ohio, USA
    Nutrition 24:733-43. 2008
    ..The present study was designed to evaluate a standardized preparation of POMx using collagen-induced arthritis (CIA) in mice, a widely used animal model of rheumatoid arthritis...
  31. ncbi Assessment of the genotoxic risk of Punica granatum L. (Punicaceae) whole fruit extracts
    Angel Sánchez-Lamar
    Departamento de Biologia Vegetal, Laboratorio de Toxicología Genética, Facultad de Biologia, Universidad de La Habana, Calle 25 No 455, e I y J, Vedado, C Habana, Cuba
    J Ethnopharmacol 115:416-22. 2008
    Punica granatum L. (Punicaceae) whole fruit extracts, have been used in Cuban traditional medicine as an effective drug for the treatment of respiratory diseases. This species showed interesting anti-viral activity, e.g...
  32. ncbi Antiplasmodial activity of Punica granatum L. fruit rind
    Mario dell'Agli
    Department of Pharmacological Sciences, University of Camerino, Italy
    J Ethnopharmacol 125:279-85. 2009
    Sun-dried rind of the immature fruit of Punica granatum L. (Punicaceae) (Pg) is presently used as a herbal formulation (OMARIA) in Orissa, India, for the therapy and prophylaxis of malaria...
  33. ncbi Pomegranate extract inhibits Staphylococcus aureus growth and subsequent enterotoxin production
    L C Braga
    Departamento de Biologia Geral, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
    J Ethnopharmacol 96:335-9. 2005
    In Brazil, pomegranate (Punica granatum L. (Punicaceae)) is widely used as a phytotherapeutic agent. This study evaluates the effect of pomegranate extract on Staphylococcus aureus FRI 722 growth and subsequent enterotoxin production...
  34. pmc Punica granatum L. extract inhibits IL-1beta-induced expression of matrix metalloproteinases by inhibiting the activation of MAP kinases and NF-kappaB in human chondrocytes in vitro
    Salahuddin Ahmed
    Division of Rheumatic Diseases, Department of Medicine, Case Western University, Cleveland, OH 44106, USA
    J Nutr 135:2096-102. 2005
    ..Taken together, these novel results indicate that PFE or compounds derived from it may inhibit cartilage degradation in OA and may also be a useful nutritive supplement for maintaining joint integrity and function...
  35. ncbi Bioavailability of ellagic acid in human plasma after consumption of ellagitannins from pomegranate (Punica granatum L.) juice
    Navindra P Seeram
    Center for Human Nutrition, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Clin Chim Acta 348:63-8. 2004
    ..We conducted in vivo studies whereby a human subject consumed pomegranate juice (PJ) (180 ml) containing EA (25 mg) and ETs (318 mg, as punicalagins, the major fruit ellagitannin)...
  36. ncbi Pomegranate as a cosmeceutical source: pomegranate fractions promote proliferation and procollagen synthesis and inhibit matrix metalloproteinase-1 production in human skin cells
    Muhammad Nadeem Aslam
    Department of Pathology, The University of Michigan Medical School, 1301 Catherine Road Box 0602, Ann Arbor, MI 48109, USA
    J Ethnopharmacol 103:311-8. 2006
    ....
  37. ncbi Pomegranate fruit extract modulates UV-B-mediated phosphorylation of mitogen-activated protein kinases and activation of nuclear factor kappa B in normal human epidermal keratinocytes paragraph sign
    Farrukh Afaq
    Department of Dermatology, University of Wisconsin, 1300 University Avenue, Madison, WI 53706, USA
    Photochem Photobiol 81:38-45. 2005
    ....
  38. ncbi Anthocyanin- and hydrolyzable tannin-rich pomegranate fruit extract modulates MAPK and NF-kappaB pathways and inhibits skin tumorigenesis in CD-1 mice
    Farrukh Afaq
    Department of Dermatology, University of Wisconsin, Madison, WI 53706, USA
    Int J Cancer 113:423-33. 2005
    ..Thus, an in-depth study to define active agent(s) in PFE capable of affording antitumor-promoting effect is warranted...
  39. pmc Pomegranate juice and extracts provide similar levels of plasma and urinary ellagitannin metabolites in human subjects
    Navindra P Seeram
    Center for Human Nutrition, David Geffen School of Medicine, Los Angeles California, USA
    J Med Food 11:390-4. 2008
    ..This study demonstrates that ellagitannin metabolites, delivered from pomegranate fruits, as PJ, POMxl, and POMxp, reach equivalent levels with a delay in time of maximum concentration of POMxp compared to PJ and POMxl...
  40. ncbi Studies on the toxicity of Punica granatum L. (Punicaceae) whole fruit extracts
    Alexis Vidal
    Department of Biochemistry, Faculty of Biology, University of Havana, Havana, Cuba
    J Ethnopharmacol 89:295-300. 2003
    ..b>Punicaceae), used in Cuban traditional medicine a.o. for the treatment of respiratory diseases...
  41. ncbi Inhibitory effect of an ellagic acid-rich pomegranate extract on tyrosinase activity and ultraviolet-induced pigmentation
    Mineka Yoshimura
    Research and Development Division, Kikkoman Corporation, Noda City, Chiba, Japan
    Biosci Biotechnol Biochem 69:2368-73. 2005
    ..PE, when taken orally, may be used as an effective whitening agent for the skin...
  42. pmc Antimicrobial activities of pomegranate rind extracts: enhancement by addition of metal salts and vitamin C
    Erin M McCarrell
    School of Life Sciences, Kingston University, Kingston upon Thames, UK
    BMC Complement Altern Med 8:64. 2008
    ..The aim of this study was to determine the antimicrobial activities of combinations of pomegranate rind extracts (PRE) with a range of metals salts with the added stabiliser vitamin C...
  43. ncbi Macrophage paraoxonase 2 (PON2) expression is up-regulated by pomegranate juice phenolic anti-oxidants via PPAR gamma and AP-1 pathway activation
    Maayan Shiner
    Lipid Research Laboratory, Technion Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciences and Rambam Medical Center, Haifa 31096, Israel
    Atherosclerosis 195:313-21. 2007
    ....
  44. ncbi The application of polyamines by pressure or immersion as a tool to maintain functional properties in stored pomegranate arils
    Seyed Hossein Mirdehghan
    Department of Food Technology, Department of Applied Biology, EPSO, University Miguel Hernandez, ctra Beniel Km 3 2, 03312 Orihuela, Alicante, Spain
    J Agric Food Chem 55:755-60. 2007
    ..Moreover, Spd showed the best results on increasing TAA through maintenance of total phenolic compounds...
  45. ncbi In vitro studies on the binding, antioxidant, and cytotoxic actions of punicalagin
    Anand P Kulkarni
    Fruit and Vegetable Technology Department, Central Food Technological Research Institute, Mysore 570 020, India
    J Agric Food Chem 55:1491-500. 2007
    ....
  46. ncbi Protective effects of standardized pomegranate (Punica granatum L.) polyphenolic extract in ultraviolet-irradiated human skin fibroblasts
    Lisbeth A Pacheco-Palencia
    Department of Nutrition and Food Science, Texas A and M University, College Station, Texas 77843, USA
    J Agric Food Chem 56:8434-41. 2008
    ..9 to 8.6 muM Trolox equivalents/mL). Results from this study demonstrate the protective effects of PE against UVA- and UVB-induced cell damage and the potential use of pomegranate polyphenolics in topical applications...
  47. ncbi Selected fruits reduce azoxymethane (AOM)-induced aberrant crypt foci (ACF) in Fisher 344 male rats
    J Boateng
    Nutritional Biochemistry and Carcinogenesis Laboratory, Department of Food and Animal Sciences, Alabama A and M University, Normal, AL 35762, United States
    Food Chem Toxicol 45:725-32. 2007
    ..05) higher in the rats fed fruits and fruit juices compared with the control. Our findings suggest that among the fruits and fruit juices, BLU and POJ contributed to significant (P<0.05) reductions in the formation of AOM-induced ACF...
  48. ncbi Consumption of wonderful variety pomegranate juice and extract by diabetic patients increases paraoxonase 1 association with high-density lipoprotein and stimulates its catalytic activities
    Wasseem Rock
    Internal Medicine C Department, Ha Emek Medical Center, Afula, Israel
    J Agric Food Chem 56:8704-13. 2008
    ..These beneficial effects of pomegranate consumption on serum PON1 stability and activity could lead to retardation of atherosclerosis development in diabetic patients...
  49. ncbi Removal of phenolic compounds in pomegranate juices using ultrafiltration and laccase-ultrafiltration combinations
    Neslihan Alper
    Ankara Provincial Control Laboratory, Ankara, Turkey
    Nahrung 48:184-7. 2004
    ..We decided in this study that laccase treatment can not be applied due to the loss of natural red color and unwanted dark brownish color formation in pomegranate juice...
  50. ncbi Cytoprotective effect of preparations from various parts of Punica granatum L. fruits in oxidatively injured mammalian cells in comparison with their antioxidant capacity in cell free systems
    Piero Sestili
    Istituto di Farmacologia e Farmacognosia, Universita degli Studi di Urbino Carlo Bo, Urbino, Italy
    Pharmacol Res 56:18-26. 2007
    ..Based on these results, the development and evaluation of rinds-only based derivatives for antiatherogenic preventive purposes in humans should be encouraged...
  51. ncbi Evaluation of antioxidant activity and preventing DNA damage effect of pomegranate extracts by chemiluminescence method
    Shanshan Guo
    Department of Food Chemistry and Molecular Biology, College of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, China
    J Agric Food Chem 55:3134-40. 2007
    ..Also, the statistical analysis indicated that there were significant differences (at P < 0.05) among the extracts of the different varieties and parts in each system...
  52. ncbi Oral consumption of pomegranate fruit extract inhibits growth and progression of primary lung tumors in mice
    Naghma Khan
    Department of Dermatology and Biostatistics and Medical Informatics, University of Wisconsin Paul P Carbone Comprehensive Cancer Center, University of Wisconsin Madison, Madison, Wisconsin, USA
    Cancer Res 67:3475-82. 2007
    ..Thus, our data show that PFE significantly inhibits lung tumorigenesis in A/J mice and merits investigation as a chemopreventive agent for human lung cancer...
  53. ncbi Safety and antioxidant activity of a pomegranate ellagitannin-enriched polyphenol dietary supplement in overweight individuals with increased waist size
    David Heber
    Center for Human Nutrition, University of California, Los Angeles, CA 90095, USA
    J Agric Food Chem 55:10050-4. 2007
    ..These studies demonstrate the safety of a pomegranate ellagitannin-enriched polyphenol dietary supplement in humans and provide evidence of antioxidant activity in humans...
  54. ncbi Ellagic acid, pomegranate and prostate cancer -- a mini review
    Carolyn Bell
    School of Pharmacy, Medical Biology Centre, Queens University of Belfast, 97 Lisburn Road, Belfast, BT9 7BL, UK
    J Pharm Pharmacol 60:139-44. 2008
    ..In this mini review the effects of pomegranate extracts and ellagic acid on the proliferation of prostate cancer cells and their future potential are discussed...
  55. ncbi Pomegranate peel extract prevents liver fibrosis in biliary-obstructed rats
    Hale Z Toklu
    Department of Pharmacology, School of Pharmacy, Marmara University, Istanbul, Turkey
    J Pharm Pharmacol 59:1287-95. 2007
    ..It therefore seems likely that PPE, with its antioxidant and antifibrotic properties, may be of potential therapeutic value in protecting the liver from fibrosis and oxidative injury due to biliary obstruction...
  56. ncbi Antioxidant activity, polyphenol content, and related compounds in different fruit juices and homogenates prepared from 29 different pomegranate accessions
    Revital Tzulker
    Migal Galilee Technology Center, P O Box 831, Kiryat Shmona, 11016, Israel
    J Agric Food Chem 55:9559-70. 2007
    ..Unlike the arils, the antioxidant level in the homogenates correlated significantly to the content of the four hydrolyzable tannins in which punicalagin is predominant, while no correlation was found to the level of anthocyanins...
  57. pmc Pomegranate polyphenols and resveratrol protect the neonatal brain against hypoxic-ischemic injury
    Tim West
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    Dev Neurosci 29:363-72. 2007
    ..These and other recent findings suggest that polyphenols should be further investigated as a potential treatment to decrease brain injury due to neonatal H-I...
  58. ncbi Medicinal values of fruit peels from Citrus sinensis, Punica granatum, and Musa paradisiaca with respect to alterations in tissue lipid peroxidation and serum concentration of glucose, insulin, and thyroid hormones
    Hamendra Singh Parmar
    School of Life Sciences, Devi Ahilya University, Indore, MP, India
    J Med Food 11:376-81. 2008
    ..Besides antiperoxidative activity, C. sinensis extract has antithyroidal, hypoglycemic, and insulin stimulatory properties, which suggest its potential to ameliorate both hyperthyroidism and diabetes mellitus...
  59. ncbi Antioxidant, antimalarial and antimicrobial activities of tannin-rich fractions, ellagitannins and phenolic acids from Punica granatum L
    Muntha K Reddy
    Department of Pharmacognosy, School of Pharmacy, The University of Mississippi, USA
    Planta Med 73:461-7. 2007
    ..Our results suggest a beneficial effect from the daily intake of POMx and pomegranate juice (PJ) as dietary supplements to augment the human immune system's antioxidant, antimalarial and antimicrobial capacities...
  60. ncbi Comparison of antioxidant potency of commonly consumed polyphenol-rich beverages in the United States
    Navindra P Seeram
    Center for Human Nutrition, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    J Agric Food Chem 56:1415-22. 2008
    ..Although in vitro antioxidant potency does not prove in vivo biological activity, there is also consistent clinical evidence of antioxidant potency for the most potent beverages including both PJ and red wine...
  61. ncbi Pomegranate juice may be a potential addition to anti-Behçet armamentarium: a hypothesis
    Afshin Borhani Haghighi
    Department of Neurology, Shiraz University of Medical Sciences, Shiraz, Iran
    Clin Rheumatol 26:1709-10. 2007
    ..We speculate that local or systemic administration of the pomegranate juice may be useful in the treatment of BD. Immunomodulatory, antioxidants and antibacterial characteristics of pomegranate juice may rationalize this hypothesis...
  62. ncbi Punica granatum (pomegranate) extract is active against dental plaque
    Silvana M S Menezes
    Faculty of Medicine of Juazeiro do Norte, Ceara, Brazil
    J Herb Pharmacother 6:79-92. 2006
    ..0 +/- 15.85 and distilled water, 71.9 +/- 8.68). The HAE presented also an antibacterial activity against selected microorganisms, and may be a possible alternative for the treatment of dental plaque bacteria...
  63. ncbi Punica granatum (pomegranate) and its potential for prevention and treatment of inflammation and cancer
    Ephraim P Lansky
    Punisyn Pharmaceuticals Ltd, Haifa, Israel
    J Ethnopharmacol 109:177-206. 2007
    ....
  64. ncbi Constituents of the flowers of Punica granatum
    Rufeng Wang
    Laboratory of Pharmaceutical Sciences, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing, 100084, China
    Fitoterapia 77:534-7. 2006
    ..The structure of compound 1 was determined by spectroscopic analysis. Maslinic acid exhibited antioxidant activity, evaluated by measurement of LDL susceptibility to oxidation...
  65. ncbi Pomegranate juice sugar fraction reduces macrophage oxidative state, whereas white grape juice sugar fraction increases it
    Orit Rozenberg
    The Lipid Research Laboratory, The Technion Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciences and Rambam Medical Center, Haifa, Israel
    Atherosclerosis 188:68-76. 2006
    ..These antioxidant/antiatherogenic effects could be due to the presence of unique complex sugars and/or phenolic sugars in PJ...
  66. ncbi Pomegranate juice supplementation in chronic obstructive pulmonary disease: a 5-week randomized, double-blind, placebo-controlled trial
    B Cerda
    Department of Food Science and Technology, Research Group on Quality, Safety and Bioactivity of Plant Foods, CEBAS CSIC, Murcia, Spain
    Eur J Clin Nutr 60:245-53. 2006
    ....
  67. ncbi Punica granatum (pomegranate) flower extract possesses potent antioxidant activity and abrogates Fe-NTA induced hepatotoxicity in mice
    Gurpreet Kaur
    Department of Medical Elementology and Toxicology, Faculty of Science, Jamia Hamdard, Hamdard Nagar, New Delhi 110062, India
    Food Chem Toxicol 44:984-93. 2006
    Most pomegranate (Punica granatum Linn., Punicaceae) fruit parts are known to possess enormous antioxidant activity. The present study evaluated antioxidant and hepatoprotective activity of pomegranate flowers...
  68. ncbi Maternal dietary supplementation with pomegranate juice is neuroprotective in an animal model of neonatal hypoxic-ischemic brain injury
    David J Loren
    Division of Neonatology, University of Washington, Seattle, WA 98195, USA
    Pediatr Res 57:858-64. 2005
    ..These results demonstrate that maternal dietary supplementation with pomegranate juice is neuroprotective for the neonatal brain...
  69. ncbi Beware of pomegranates bearing 40% ellagic Acid
    Ephraim Philip Lansky
    Rimonest Ltd, Haifa, Israel
    J Med Food 9:119-22. 2006
    ..The implications of this strategy may be generalized for the optimization of nutraceutical preparations from other medicinal plants as well...
  70. ncbi Photochemopreventive effect of pomegranate fruit extract on UVA-mediated activation of cellular pathways in normal human epidermal keratinocytes
    Deeba N Syed
    Department of Dermatology, University of Wisconsin, Madison, WI, USA
    Photochem Photobiol 82:398-405. 2006
    ..Our data suggest that PFE is an effective agent for ameliorating UVA-mediated damages by modulating cellular pathways and merits further evaluation as a photochemopreventive agent...
  71. ncbi Pomegranate (Punica granatum) pure chemicals show possible synergistic inhibition of human PC-3 prostate cancer cell invasion across Matrigel
    Ephraim Philip Lansky
    Rimonest Ltd, P O B 9945, Haifa, Israel
    Invest New Drugs 23:121-2. 2005
    ..When C, P, and L were equally combined at the same gross dosage (4 microg/ml) as when the compounds were tested individually, a supradditive inhibition of invasion was observed, measured by the Kruskal-Wallis non-parametric test...
  72. ncbi The inhibition of gastric mucosal injury by Punicagranatum L. (pomegranate) methanolic extract
    K B Ajaikumar
    Amala Cancer Research Centre, Amala Nagar, Thrissur 680555, Kerala, India
    J Ethnopharmacol 96:171-6. 2005
    ..All of these symptoms were found to be normal in treated groups. In general, the results of the present investigation revealed the gastroprotective activity of the extract through antioxidant mechanism...
  73. ncbi Antioxidant activity of plant extracts on the inhibition of citral off-odor formation
    Chia Pei Liang
    Department of Food Science, Rutgers University, New Brunswick, NJ 08901 8520, USA
    Mol Nutr Food Res 48:308-17. 2004
    ..Our results suggest that these plant extracts act as general antioxidants inhibiting the generation ofp-methylacetophenone regardless of the types of water-soluble phenolic compounds existing in the plant extracts...
  74. ncbi Repeated oral administration of high doses of the pomegranate ellagitannin punicalagin to rats for 37 days is not toxic
    Begoña Cerdá
    Research Group on Quality, Safety and Bioactivity of Plant Foods, Department of Food Science and Technology, CEBAS CSIC, P O Box 4195, 30080 Murcia, Spain
    J Agric Food Chem 51:3493-501. 2003
    ..However, taking into account the high punicalagin content of pomegranate-derived foodstuffs, safety evaluation should be also carried out in humans with a lower dose and during a longer period of intake...
  75. ncbi Differentiation-promoting activity of pomegranate (Punica granatum) fruit extracts in HL-60 human promyelocytic leukemia cells
    Satoru Kawaii
    Laboratory of Bio organic Chemistry, Tokyo Denki University, Saitama, Japan
    J Med Food 7:13-8. 2004
    ..The results highlight an important, previously unknown, mechanism of the cancer preventive and suppressive potential of pomegranate fermented juice and pericarp extracts...
  76. ncbi Effects of a pomegranate fruit extract rich in punicalagin on oxidation-sensitive genes and eNOS activity at sites of perturbed shear stress and atherogenesis
    Filomena de Nigris
    Department of General Pathology, School of Medicine, University of Naples, 80134 Naples, Italy
    Cardiovasc Res 73:414-23. 2007
    ..Polyphenolic antioxidants contained in the juice derived from the pomegranate contribute to the reduction of oxidative stress and atherogenesis during disturbed shear stress...
  77. ncbi Pomegranate fruit extract inhibits prosurvival pathways in human A549 lung carcinoma cells and tumor growth in athymic nude mice
    Naghma Khan
    Department of Dermatology, University of Wisconsin, Madison, WI 53706, USA
    Carcinogenesis 28:163-73. 2007
    ..2%, wt/vol) to athymic nude mice implanted with A549 cells resulted in a significant inhibition in tumor growth. Our results provide a suggestion that PFE can be a useful chemopreventive/chemotherapeutic agent against human lung cancer...
  78. ncbi Pomegranate juice consumption for 3 years by patients with carotid artery stenosis reduces common carotid intima-media thickness, blood pressure and LDL oxidation
    Michael Aviram
    The Lipid Research Laboratory, Rappaport Family Institute for Research in the Medical Sciences, Rambam Medical Center, Haifa 31096, Israel
    Clin Nutr 23:423-33. 2004
    ..The results of the present study thus suggest that PJ consumption by patients with CAS decreases carotid IMT and systolic blood pressure and these effects could be related to the potent antioxidant characteristics of PJ polyphenols...
  79. ncbi Study on wound healing activity of Punica granatum peel
    K N Chidambara Murthy
    Department of Plant Cell Biotechnology, Central Food Technological Research Institute, Mysore 570 020, Karnataka, India
    J Med Food 7:256-9. 2004
    ..High-performance liquid chromatography analysis of the extract showed the presence of gallic acid and catechin as major components...
  80. ncbi beta-Secretase (BACE1) inhibitors from pomegranate (Punica granatum) husk
    Hye Min Kwak
    School of Applied Biosciences, College of Agriculture and Life Sciences, Kyungpook National University, Daegu, Korea
    Arch Pharm Res 28:1328-32. 2005
    ..Ellagic acid and punicalagin were less inhibitory to alpha-secretase (TACE) and other serine proteases such as chymotrypsin, trypsin, and elastase, thus indicating that they were relatively specific inhibitors of BACE1...
  81. ncbi Antibacterial properties of traditionally used Indian medicinal plants
    F Aqil
    Department of Agricultural Microbiology, Aligarh Muslim University, Aligarh, India
    Methods Find Exp Clin Pharmacol 29:79-92. 2007
    ..Further, identification of active constituents in each fraction and their additive and synergistic interactions are needed to exploit them in evaluating efficacy and safety in vivo against MDR bacteria...
  82. ncbi Fungal control of pathogenic fungi isolated from wild plants in Taif Governorate, Saudia Arabia
    A M Abou-Zeid
    Biology Department, Faculty of Science, Taif University, Saudi Arabia P B
    Roum Arch Microbiol Immunol 66:90-6. 2007
    ..Coating plant stems with antagonists or with antagonist extracts reduce the severity of the disease but not prevent it in all tested pathogens...
  83. ncbi Phytotherapeutics: an evaluation of the potential of 1000 plants
    G Cravotto
    Dipartimento di Scienza e Tecnologia del Farmaco, University of Turin, Turin, Italy
    J Clin Pharm Ther 35:11-48. 2010
    ..The aim is to provide broad coverage of as many potentially useful plants as possible and then to focus on those with the greatest therapeutic potential...
  84. ncbi Traditional medicinal plants of cold desert Ladakh-used against kidney and urinary disorders
    Basant Ballabh
    Field Research Laboratory, Defence Research and Development Organisation Leh Ladakh, J and K, India
    J Ethnopharmacol 118:331-9. 2008
    ....
  85. ncbi Effective medicinal plants against enterohaemorrhagic Escherichia coli O157:H7
    Supayang Voravuthikunchai
    School of Biotechnology and Biomolecular Sciences, The University of New South Wales, Sydney 2052, Australia
    J Ethnopharmacol 94:49-54. 2004
    ..09, 0.78, and 0.19, 0.39 mg/ml, respectively. These plant species may provide alternative but bioactive medicines for the treatment of Escherichia coli O157:H7 infection...
  86. ncbi Antioxidant activity of some Jordanian medicinal plants used traditionally for treatment of diabetes
    Ahmed H Al-Mustafa
    Department of Biology, Faculty of Science, Mutah University, P O Box 7, Postal Code 61710, Mutah Al Karak, Jordan
    Pak J Biol Sci 11:351-8. 2008
    ..The antioxidant activity of these plant's extracts and their potential rule in radical scavenging agreed with their potential use by Jordanian population as a traditional anti-diabetic agents...
  87. ncbi Ability of certain plant extracts traditionally used to treat ciguatera fish poisoning to inhibit nitric oxide production in RAW 264.7 macrophages
    Shilpa Kumar-Roine
    Universite de Toulouse, UPS, UMR 152 Laboratoire de Pharmacochimie des Substances Naturelles et Pharmacophores Redox, 118 Rte de Narbonne, F 31062 Toulouse Cedex 9, France
    J Ethnopharmacol 123:369-77. 2009
    ..Many traditional remedies are commonly used in the Pacific against CFP. In this context, bioassay-guided screening was carried out to study NO inhibiting capacity of 28 selected plant extracts...
  88. ncbi Preparation and characterization of herbal creams for improvement of skin viscoelastic properties
    M S Ahshawat
    Institute of Pharmacy, Pt Ravishankar Shukla University, Raipur, Chhattisgarh 03132002, India
    Int J Cosmet Sci 30:183-93. 2008
    ..86 +/- 0.86% and 29.89 +/- 2.8%, respectively) and improved skin hydration (15.97 +/- 0.55 and 18.27 +/- 0.99%, respectively) and were found more effective compared with the control product (C7) after the 6- week study...
  89. ncbi In vitro susceptibility of Entamoeba histolytica and Giardia lamblia to plants used in Mexican traditional medicine for the treatment of gastrointestinal disorders
    Fernando Calzada
    Unidad de Investigación Médica en Farmacología de Productos Naturales, Hospital de Pediatria, 2 Piso, Centro Medico Nacional Siglo XXI, IMSS, Av Cuauhtemoc 330, Col Doctores, CP 06725, Mexico, DF, Mexico
    J Ethnopharmacol 108:367-70. 2006
    ..The results of the antiprotozoal screening support the popular uses of the studied species for the treatment of diarrhoea and dysentery in Mexican traditional medicine...
  90. ncbi A systematic screening of total antioxidants in dietary plants
    Bente L Halvorsen
    Institute for Nutrition Research, Faculty of Medicine, University of Oslo, Blindern, 0316 Oslo, Norway
    J Nutr 132:461-71. 2002
    ..Ericaceae (blueberry), Grossulariaceae (black currant), Juglandaceae (walnut), Asteraceae (sunflower seed), Punicaceae (pomegranate) and Zingiberaceae (ginger). In a Norwegian diet, fruits, berries and cereals contributed 43.6%, 27...
  91. ncbi Effect of cold stratification treatments on germination of drought tolerant shrubs seeds
    Zafer Olmez
    Artvin Faculty of Forestry, Kafkas University, Artvin 08000, Turkey
    J Environ Biol 28:447-53. 2007
    ..3% for Colutea armena for 20 days cold stratified seeds and sown under open field conditions. Furthermore, the highest GP were obtained from seeds of Cistus creticus (27.5%) and Elaeagnus angustifolia (56.2%) in control sowing...
  92. pmc Effects of fruit ellagitannin extracts, ellagic acid, and their colonic metabolite, urolithin A, on Wnt signaling
    Meenakshi Sharma
    Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Kingston, Rhode Island 02881, USA
    J Agric Food Chem 58:3965-9. 2010
    ..0 microg/mL; 63 microM), and UA (IC(50) = 9.0 microg/mL; 39 microM) inhibited Wnt signaling, suggesting that ET-rich foods have potential against colon carcinogenesis and that urolithins are relevant bioactive constituents in the colon...
  93. pmc Antibacterial Activity of Medicinal Plants Against Pathogens causing Complicated Urinary Tract Infections
    Anjana Sharma
    Bacteriology Laboratory, Department of Post Graduate Studies and Research in Biological Sciences, R D University, Jabalpur 482 001, India
    Indian J Pharm Sci 71:136-9. 2009
    ..The results support the folkloric use of these plants in the treatment of urinary tract infections by the tribals of Mahakoshal region of central India...
  94. ncbi Antidiabetic screening of commercial botanical products in 3T3-L1 adipocytes and db/db mice
    John G Babish
    Bionexus, Ithaca, New York 14850, USA
    J Med Food 13:535-47. 2010
    ....
  95. ncbi Effect of certain plant extracts on alpha-amylase activity
    D Prashanth
    Bioassay Unit, Research and Development Centre, Natural Remedies Pvt Ltd, Plot No 5B, Veerasandra Indl Area, Hosur Road, 561 229, Bangalore, India
    Fitoterapia 72:179-81. 2001
    ..P. granatum and M. indica were found to exhibit interesting alpha-amylase inhibitory activity...
  96. ncbi Extensive screening for edible herbal extracts with potent scavenging activity against superoxide anions
    Keita Saito
    New Industry Creation Hatchery Center, Tohoku University, Aramaki, Sendai, Japan
    Plant Foods Hum Nutr 63:65-70. 2008
    ..These results with such large scale screening might give useful information when choosing a potent antioxidant as a foodstuff...
  97. ncbi An ethnobotanical study of medicinal plants in Chandauli District of Uttar Pradesh, India
    Anurag Singh
    Department of Botany, Udai Pratap Autonomous College, Varanasi, UttarPradesh 221002, India
    J Ethnopharmacol 121:324-9. 2009
    ..The present paper synthesizes the first report related to the documentation and conservation of ethnomedicinal plants of Chandauli district and their socio-economic relationship with the forests and its resources...
  98. ncbi Effect of an herbal formula containing Ganoderma lucidum on reduction of herpes zoster pain: a pilot clinical trial
    Yasuyo Hijikata
    Toyodo Hijikata Clinic, Osaka 567 0031, Japan
    Am J Chin Med 33:517-23. 2005
    ....
  99. ncbi Screening of Nepalese crude drugs traditionally used to treat hyperpigmentation: in vitro tyrosinase inhibition
    A Adhikari
    The School of Pharmaceutical and Biomedical Sciences, Pokhara University, Pokhara, PO Box 427, Pokhara, Nepal
    Int J Cosmet Sci 30:353-60. 2008
    ..Further evaluation of the most potent tyrosinase inhibitors in in vivo conditions would be recommended...
  100. pmc Effect of walnut leaf, coriander and pomegranate on blood glucose and histopathology of pancreas of alloxan induced diabetic rats
    Gholamali Jelodar
    Department of Physiology, College of Veterinary Medicine, Shiraz University Shiraz, Iran
    Afr J Tradit Complement Altern Med 4:299-305. 2007
    ..05)...
  101. ncbi Studies on modulation of DNA integrity in Fenton's system by phytochemicals
    Palayyan Saraswathy Benherlal
    Agro Processing and Natural Products Division, National Institute for Interdisciplinary Science and Technology, CSIR, Thiruvananthapuram 695019, India
    Mutat Res 648:1-8. 2008
    ..Commonly consumed phytochemicals such as vitamin C and gallic acid with their high reducing power and at higher physiological concentration, could regenerate free iron for Fenton's reaction leading to DNA damage as shown here...

Research Grants15

  1. CHONDROPROTECTIVE ACTIVITY OF POMEGRANATE EXTRACT
    Tariq M Haqqi; Fiscal Year: 2010
    ..Our findings are likely to open the door for the development of novel therapeutic strategies for the treatment of OA. ..
  2. MECHANISMS OF CHONDROPROTECTION BY POMEGRANATE FRUIT EXTRACT
    Tariq M Haqqi; Fiscal Year: 2011
    ..Our findings may open new avenues regarding the use of PFE or compounds derived from it for the treatment and/or prevention of OA. ..
  3. Anti-HIV Microbicide: Cellulose Acetate Phthalate (CAP)
    A Robert Neurath; Fiscal Year: 2004
    ..The proposed research is expected to help transform this ideal into a reality. ..
  4. Occupational exposure and the developmental-basis of AD
    Nasser Zawia; Fiscal Year: 2008
    ..We further would like to examine the mechanisms associated with sensitization of animals to disease by early life exposure and how such processes respond in the event of re-exposure during adulthood. ..
  5. Neonatal exposure & neurodegeneration of the aged brain
    Nasser Zawia; Fiscal Year: 2006
    ..We would like to test this hypothesis by examining the effect of Pb exposure on DNA-methylation and determine whether these actions selectively impact genes rich in GC box elements such as APP and BACE. ..
  6. Fetal Pb-exposure and neurodegeneration in aging brains
    Nasser Zawia; Fiscal Year: 2006
    ..abstract_text> ..
  7. INTERACTION OF LEAD WITH ZINC FINGER PROTEINS
    Nasser Zawia; Fiscal Year: 2002
    ..Understanding the mechanism of lead neurotoxicity with the models and experiments hitherto proposed will shed more light on metal toxicity and broaden our knowledge of the impact of heavy metals in the environment on our health. ..
  8. Genetic and molecular characterization of kidney cancer
    Allan Pantuck; Fiscal Year: 2005
    ..abstract_text> ..
  9. Arginase and Nitric Oxide in Atherosclerosis
    Louis Ignarro; Fiscal Year: 2004
    ..The feasibility of this approach is borne out by the extensive preliminary data that support the central hypothesis. ..
  10. THE UCLA CLINICAL NUTRITION RESEARCH UNIT
    David Heber; Fiscal Year: 2006
    ..The UCLA CNRU is serving as a regional and national resource at the cutting edge of nutrition and cancer prevention research...
  11. Cancer Chemoprevention by Pomegranate Fruit Extract
    Farrukh Afaq; Fiscal Year: 2006
    ..HEALTH RELEVANCE: This proposal intends to define a novel photochemo- preventive agent against skin cancer for its possible use in humans. ..
  12. UCLA TRAINING PROGRAM IN NUTRITION AND OBESITY
    David Heber; Fiscal Year: 2007
    ..abstract_text> ..
  13. Monocyte / Macrophage TLR4 Expression and Signaling: A Link between Obesity and C
    Brian McFarlin; Fiscal Year: 2008
    ..The primary purpose of this investigation is to determine if obesity status alters TLR4 signaling and/or inflammatory cytokine production in blood monocyte and adipose tissue macrophage. [unreadable] [unreadable] [unreadable]..
  14. REGULATION OF EXPRESSION OF NO SYNTHASE
    Louis Ignarro; Fiscal Year: 2002
    ..The proposed research represents a continuing long-term effort to elucidate the biological factors influencing the vascular and related actions of NO in health and disease. ..
  15. CYTOSTATIC ROLE OF THE ARGININE-NITRIC OXIDE PATHWAY
    Louis Ignarro; Fiscal Year: 2001
    ..The proposed research should advance our understanding of the biological role of NO synthase in regulating cell proliferation. ..