piper nigrum

Summary

Summary: A plant species in the PIPERACEAE plant family. It is a common spice on foods and is used medicinally to increase gastrointestinal assimilation of other supplements and drugs. PIPERINE is a key component. Black pepper is picked unripe and heaped for a few days to ferment. White Pepper is the ripe fruit dehulled by maceration in water.

Top Publications

  1. doi A rapid method for isolation of piperine from the fruits of Piper nigrum Linn
    Niranjan Kanaki
    Department of Phytochemistry and Pharmacognosy, B V Patel Pharmaceutical Education and Research Development Centre, Thaltej Gandhinagar Highway, Thaltej, Ahmedabad, 380 054, Gujarat, India
    J Nat Med 62:281-3. 2008
  2. ncbi Antioxidant efficacy of black pepper (Piper nigrum L.) and piperine in rats with high fat diet induced oxidative stress
    R S Vijayakumar
    Department of Biochemistry, Annamalai University, Annamalai Nagar, Tamilnadu, India
    Redox Rep 9:105-10. 2004
  3. ncbi Amides from Piper nigrum L. with dissimilar effects on melanocyte proliferation in-vitro
    Zhixiu Lin
    Department of Pharmacy, King s College London, 150 Stamford Street, London SE1 9NN, UK
    J Pharm Pharmacol 59:529-36. 2007
  4. doi Endophytic bacterial flora in root and stem tissues of black pepper (Piper nigrum L.) genotype: isolation, identification and evaluation against Phytophthora capsici
    R Aravind
    Indian Institute of Spices Research, Calicut, Kerala, India
    Lett Appl Microbiol 48:58-64. 2009
  5. doi Piperine, a piperidine alkaloid from Piper nigrum re-sensitizes P-gp, MRP1 and BCRP dependent multidrug resistant cancer cells
    Sen Li
    College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300071, People s Republic of China
    Phytomedicine 19:83-7. 2011
  6. doi In vitro investigation of the potential immunomodulatory and anti-cancer activities of black pepper (Piper nigrum) and cardamom (Elettaria cardamomum)
    Amin F Majdalawieh
    Department of Biology and Chemistry, Faculty of Arts and Sciences, American University of Sharjah, Sharjah, United Arab Emirates
    J Med Food 13:371-81. 2010
  7. doi Pellitorine, a potential anti-cancer lead compound against HL6 and MCT-7 cell lines and microbial transformation of piperine from Piper Nigrum
    Gwendoline Cheng Lian Ee
    Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, Selangor, Malaysia
    Molecules 15:2398-404. 2010
  8. ncbi Inhibitory effects of black pepper (Piper nigrum) extracts and compounds on human tumor cell proliferation, cyclooxygenase enzymes, lipid peroxidation and nuclear transcription factor-kappa-B
    Yunbao Liu
    Bioactive Natural Products and Phytoceuticals, Department of Horticulture and National Food Safety and Toxicology Center, Michigan State University, East Lansing, Michigan 48824, USA
    Nat Prod Commun 5:1253-7. 2010
  9. pmc Antibacterial activity of natural spices on multiple drug resistant Escherichia coli isolated from drinking water, Bangladesh
    Shahedur Rahman
    Department of Biotechnology and Genetic Engineering, Islamic University, Kushtia, Bangladesh
    Ann Clin Microbiol Antimicrob 10:10. 2011
  10. ncbi ACAT inhibition of alkamides identified in the fruits of Piper nigrum
    Mun Chual Rho
    Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology, 52 Eoundong, Yusong gu, Daejon 305 333, Republic of Korea
    Phytochemistry 68:899-903. 2007

Research Grants

  1. Clinical Assessment of Herb-Drug Interactions
    Bill Gurley; Fiscal Year: 2003
  2. Clinical Assessment of Herb-Drug Interactions
    Bill Gurley; Fiscal Year: 2004
  3. Clinical Assessment of Herb-Drug Interactions
    Bill Gurley; Fiscal Year: 2005

Scientific Experts

Detail Information

Publications138 found, 100 shown here

  1. doi A rapid method for isolation of piperine from the fruits of Piper nigrum Linn
    Niranjan Kanaki
    Department of Phytochemistry and Pharmacognosy, B V Patel Pharmaceutical Education and Research Development Centre, Thaltej Gandhinagar Highway, Thaltej, Ahmedabad, 380 054, Gujarat, India
    J Nat Med 62:281-3. 2008
    A simple, rapid and efficient method has been developed for the isolation of piperine from the fruits of Piper nigrum. The method involves extraction of the fruit powder with glacial acetic acid, from which piperine is partitioned into ..
  2. ncbi Antioxidant efficacy of black pepper (Piper nigrum L.) and piperine in rats with high fat diet induced oxidative stress
    R S Vijayakumar
    Department of Biochemistry, Annamalai University, Annamalai Nagar, Tamilnadu, India
    Redox Rep 9:105-10. 2004
    The present study was aimed to explore the effect of black pepper (Piper nigrum L.) on tissue lipid peroxidation, enzymic and non-enzymic antioxidants in rats fed a high-fat diet...
  3. ncbi Amides from Piper nigrum L. with dissimilar effects on melanocyte proliferation in-vitro
    Zhixiu Lin
    Department of Pharmacy, King s College London, 150 Stamford Street, London SE1 9NN, UK
    J Pharm Pharmacol 59:529-36. 2007
    ..b>Piper nigrum L...
  4. doi Endophytic bacterial flora in root and stem tissues of black pepper (Piper nigrum L.) genotype: isolation, identification and evaluation against Phytophthora capsici
    R Aravind
    Indian Institute of Spices Research, Calicut, Kerala, India
    Lett Appl Microbiol 48:58-64. 2009
    To isolate and identify black pepper (Piper nigrum L) associated endophytic bacteria antagonistic to Phytophthora capsici causing foot rot disease.
  5. doi Piperine, a piperidine alkaloid from Piper nigrum re-sensitizes P-gp, MRP1 and BCRP dependent multidrug resistant cancer cells
    Sen Li
    College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300071, People s Republic of China
    Phytomedicine 19:83-7. 2011
    ..These results suggest that piperine can reverse MDR by multiple mechanisms and it may be a promising lead compound for future studies...
  6. doi In vitro investigation of the potential immunomodulatory and anti-cancer activities of black pepper (Piper nigrum) and cardamom (Elettaria cardamomum)
    Amin F Majdalawieh
    Department of Biology and Chemistry, Faculty of Arts and Sciences, American University of Sharjah, Sharjah, United Arab Emirates
    J Med Food 13:371-81. 2010
    ..We anticipate that black pepper and cardamom constituents can be used as potential therapeutic tools to regulate inflammatory responses and prevent/attenuate carcinogenesis...
  7. doi Pellitorine, a potential anti-cancer lead compound against HL6 and MCT-7 cell lines and microbial transformation of piperine from Piper Nigrum
    Gwendoline Cheng Lian Ee
    Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, Selangor, Malaysia
    Molecules 15:2398-404. 2010
    Pellitorine (1), which was isolated from the roots of Piper nigrum, showed strong cytotoxic activities against HL60 and MCT-7 cell lines...
  8. ncbi Inhibitory effects of black pepper (Piper nigrum) extracts and compounds on human tumor cell proliferation, cyclooxygenase enzymes, lipid peroxidation and nuclear transcription factor-kappa-B
    Yunbao Liu
    Bioactive Natural Products and Phytoceuticals, Department of Horticulture and National Food Safety and Toxicology Center, Michigan State University, East Lansing, Michigan 48824, USA
    Nat Prod Commun 5:1253-7. 2010
    Black pepper (Piper nigrum) and hot pepper (Capsicum spp.) are widely used in traditional medicines. Although hot Capsicum spp...
  9. pmc Antibacterial activity of natural spices on multiple drug resistant Escherichia coli isolated from drinking water, Bangladesh
    Shahedur Rahman
    Department of Biotechnology and Genetic Engineering, Islamic University, Kushtia, Bangladesh
    Ann Clin Microbiol Antimicrob 10:10. 2011
    ..The present work aimed to find out the antimicrobial activity of natural spices on multi-drug resistant Escherichia coli isolates...
  10. ncbi ACAT inhibition of alkamides identified in the fruits of Piper nigrum
    Mun Chual Rho
    Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology, 52 Eoundong, Yusong gu, Daejon 305 333, Republic of Korea
    Phytochemistry 68:899-903. 2007
    In this study, via a bioactivity-guided fractionation of MeOH extracts of the fruits of Piper nigrum, alkamide (5) and five previously-identified alkamides were isolated...
  11. doi Chemistry and in vitro antioxidant activity of volatile oil and oleoresins of black pepper (Piper nigrum)
    I P S Kapoor
    Chemistry Department, DDU Gorakhpur University, Gorakhpur, India
    J Agric Food Chem 57:5358-64. 2009
    Essential oil and oleoresins (ethanol and ethyl acetate) of Piper nigrum were extracted by using Clevenger and Soxhlet apparatus, respectively...
  12. ncbi Alkamides from the fruits of Piper longum and Piper nigrum displaying potent cell adhesion inhibition
    Seung Woong Lee
    Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 305 806, Republic of Korea
    Bioorg Med Chem Lett 18:4544-6. 2008
    ..Their compounds 3-5, 7, and 8 inhibited potently the direct binding between sICAM-1 and LFA-1 of THP-1 cells in a dose-dependent manner, with IC(50) values of 10.7, 8.8, 13.4, 13.5, and 6.0 microg/mL, respectively...
  13. ncbi Melanogenesis stimulation in murine B16 melanoma cells by Piper nigrum leaf extract and its lignan constituents
    Hideaki Matsuda
    School of Pharmaceutical Sciences, Kinki University, Higashiosaka, Osaka, Japan
    Biol Pharm Bull 27:1611-6. 2004
    A methanolic extract from the leaves of Piper nigrum L. showed a significant stimulatory effect on melanogenesis in cultured murine B16 melanoma cells...
  14. ncbi Nigramides A-S, dimeric amide alkaloids from the roots of Piper nigrum
    Kun Wei
    Faculty of Pharmaceutical Sciences, Toho University, Miyama 2 2 1, Funabashi, Chiba 274 8510, Japan
    J Org Chem 70:1164-76. 2005
    ..amide alkaloids possessing a cyclobutane ring, nigramides P-S (17-20), have been isolated from the roots of Piper nigrum. Their structures were elucidated on the basis of their spectroscopic data...
  15. ncbi Protective effects of Piper nigrum and Vinca rosea in alloxan induced diabetic rats
    M Kaleem
    Department of Biochemistry, Faculty of Life Sciences, AMU, Aligarh 202 002
    Indian J Physiol Pharmacol 49:65-71. 2005
    In the present study aqueous extract of Piper nigrum seeds and Vinca rosea flowers were administered orally to alloxan induced diabetic rats once a day for 4 weeks...
  16. ncbi Mechanism-based inhibition of human liver microsomal cytochrome P450 2D6 (CYP2D6) by alkamides of Piper nigrum
    - Subehan
    Institute of Natural Medicine, University of Toyama, Toyama, Japan
    Planta Med 72:527-32. 2006
    Nineteen alkamides isolated from Piper nigrum L. were tested for their mechanism-based inhibition on human liver microsomal dextromethorphan O-demethylation activity, a prototype marker for cytochrome P450 2D6 (CYP2D6)...
  17. ncbi The effect of a synergistic concentration of a Piper nigrum extract used in conjunction with pyrethrum upon gene expression in Drosophila melanogaster
    H R Jensen
    Department of Biology, University of Ottawa, Center for Advanced Research in Environmental Genomics, Ottawa, Ontario, Canada
    Insect Mol Biol 15:329-39. 2006
    An ethyl acetate extract of Piper nigrum L. (Piperaceae) peppercorns was tested as a synergist for the botanical insecticide pyrethrum. A high synergist ratio of 11...
  18. ncbi Effect of food seasoning spices mixture on biomarkers of oxidative stress in tissues of fructose-fed insulin-resistant rats
    R Suganthi
    Department of Biochemistry, Faculty of Science, Annamalai University, Annamalai Nagar, Tamil Nadu, India
    J Med Food 10:149-53. 2007
    ..The positive effect of SM on the oxidant-antioxidant balance could be attributed to the active constituents of the different spices present in the mixture...
  19. ncbi Biochemical properties of polysaccharides from black pepper
    Hyug Chun
    Graduate School of Biotechnology, Korea University, Sungbuk Ku, Seoul
    Biol Pharm Bull 25:1203-8. 2002
    The purified polysaccharides from Piper nigrum were prepared as follows: a hot water extract of pepper seeds was fractionated by ultrafiltration with a 5-kDa-membrane cartridge...
  20. ncbi Insecticidal amides from fruits of Piper nigrum Linn
    Bina S Siddiqui
    HEJ Research Institute of Chemistry, International Centre for Chemical Sciences, University of Karachi, Karachi 75270, Pakistan
    Nat Prod Res 19:143-50. 2005
    The petroleum ether and ethyl acetate fractions of dried ground seeds of Piper nigrum Linn...
  21. ncbi Antibacterial constituents from the berries of Piper nigrum
    S Venkat Reddy
    Natural Product Laboratory, Indian Institute of Chemical Technology, Hyderabad 500 007, India
    Phytomedicine 11:697-700. 2004
    b>Piper nigrum finds an extensive application in antibacterial preparations belonging to Ayurvedic system of medicine. A bioguided extraction and fractionation of the petroleum ether extract of the berries of P...
  22. ncbi Efficacy of piperine, an alkaloidal constituent from Piper nigrum on erythrocyte antioxidant status in high fat diet and antithyroid drug induced hyperlipidemic rats
    Ramasamy Subramaniam Vijayakumar
    Department of Biochemistry, Annamalai University, Annamalainagar 608 002, Tamilnadu, India
    Cell Biochem Funct 24:491-8. 2006
    ..Thus, our results indicate that piperine supplementation markedly protects erythrocytes from oxidative stress by improving the antioxidant status in HFD fed antithyroid drug treated rats...
  23. ncbi Repellent activity of essential oils against cockroaches (Dictyoptera: Blattidae, Blattellidae, and Blaberidae) in Thailand
    Usavadee Thavara
    National Institute of Health, Department of Medical Sciences, Ministry of Public Health, Nonthaburi, Thailand
    Southeast Asian J Trop Med Public Health 38:663-73. 2007
    ..Mansf., Citrus hystrix DC., Curcuma longa L., Litsea cubeba (Lour.) Pers., Piper nigrum L., Psidium guajava L...
  24. ncbi Piperine lowers the serum concentrations of thyroid hormones, glucose and hepatic 5'D activity in adult male mice
    S Panda
    School of Life Sciences, Devi Ahilya University, Indore, India
    Horm Metab Res 35:523-6. 2003
    Piperine, the main alkaloid of Piper nigrum fruits, was evaluated for its thyroid hormone and glucose regulatory efficacy in adult male Swiss albino mice. Its daily oral administration (2...
  25. ncbi Potential use of Piper nigrum ethanol extract against pyrethroid-resistant Aedes aegypti larvae
    Naomi Kato Simas
    Nucleo de Pesquisas de Produtos Naturais, Centro de Ciencias da Saude, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ
    Rev Soc Bras Med Trop 40:405-7. 2007
    Fractionation of Piper nigrum ethanol extract, biomonitored by assays on pyrethroid-resistant Aedes aegypti larvae yielded isolation of the larvicidal amides piperolein-A and piperine. Comparing LC50 values, the ethanol extract (0...
  26. ncbi CYP3A4 inhibitory activity of new bisalkaloids, dipiperamides D and E, and cognates from white pepper
    Sachiko Tsukamoto
    Faculty of Pharmaceutical Sciences, Kanazawa University, 13 1 Takara machi, Kanazawa 920 0934, Japan
    Bioorg Med Chem 10:2981-5. 2002
    ..E, were isolated as inhibitors of a drug metabolizing enzyme cytochrome P450 (CYP) 3A4 from the white pepper, Piper nigrum. Their structures were elucidated by spectroscopic methods...
  27. ncbi Testosterone 5alpha-reductase inhibitory active constituents of Piper nigrum leaf
    Noriko Hirata
    School of Pharmaceutical Sciences, Kinki University, 3 4 1 Kowakae, Higashiosaka, Osaka 577 8502, Japan
    Biol Pharm Bull 30:2402-5. 2007
    Previously we reported that Piper nigrum leaf extract showed a potent stimulation effect on melanogenesis and that (-)-cubebin (1) and (-)-3,4-dimethoxy-3,4-desmethylenedioxycubebin (2) were isolated as active constituents...
  28. ncbi Cobalt(II)-catalyzed intermolecular Diels-Alder reaction of piperine
    Kun Wei
    Faculty of Pharmaceutical Sciences, Toho University, Funabashi, Chiba
    Org Lett 7:2833-5. 2005
    ..For elucidation of the distinction, different cobalt-catalyzed mechanisms were proposed for the Diels-Alder dimerization of piperine...
  29. pmc Pungent agents from Szechuan peppers excite sensory neurons by inhibiting two-pore potassium channels
    Diana M Bautista
    Department of Physiology, University of California, San Francisco, 600 16th St, San Francisco, California 94143 2140, USA
    Nat Neurosci 11:772-9. 2008
    ....
  30. ncbi Effect of spices on lipid metabolism in 1,2-dimethylhydrazine-induced rat colon carcinogenesis
    N Nalini
    Department of Biochemistry, Annamalai University, Annamalainagar, Tamilnadu, India
    J Med Food 9:237-45. 2006
    ..We investigated the effect of red chilli (Capsicum annum L.), cumin (Cuminum cyminum L.), and black pepper (Piper nigrum L.) on colon cancer induced in rats by a colon-specific carcinogen, 1,2-dimethylhydrazine (DMH)...
  31. ncbi Antioxidant activity of commonly consumed plant foods of India: contribution of their phenolic content
    Rita Saxena
    Division of Endocrinology and Metabolism, National Institute of Nutrition, Hyderabad, India
    Int J Food Sci Nutr 58:250-60. 2007
    ..86 and r2 =74%, respectively) and dehusked legumes (r=-0.65 and r2 = 42.2%, respectively). The results suggest that phenolics may contribute significantly to the AOA of some plant foods, such as spices and dehusked legumes...
  32. ncbi Effects of fragrance inhalation on sympathetic activity in normal adults
    Shinichiro Haze
    Product Development Center, Shiseido Co, Ltd, Hayabuchi, Yokohama, Japan
    Jpn J Pharmacol 90:247-53. 2002
    ..06), while fragrance inhalation of rose oil caused a 30% decrease in adrenaline concentration (P<0.01). Our results indicate that fragrance inhalation of essential oils may modulate sympathetic activity in normal adults...
  33. ncbi Fumigant toxicity of essential oils from some common spices against pulse beetle, Callosobruchus chinensis (Coleoptera: Bruchidae)
    Mukesh Kumar Chaubey
    Department of Zoology, Deen Dayal Upadhyay Gorakhpur University, UP, India
    J Oleo Sci 57:171-9. 2008
    ..seven common spices, Anethum graveolens, Cuminum cyminum, Illicium verum, Myristica fragrans, Nigella sativa, Piper nigrum and Trachyspermum ammi was isolated and its insecticidal, oviposition, egg hatching and developmental ..
  34. ncbi Chemical compositions and antioxidant properties of essential oils from nine species of Turkish plants obtained by supercritical carbon dioxide extraction and steam distillation
    Ummihan Topal
    Department of Applied Chemistry and Biochemistry, Kumamoto University, Kumamoto, Japan
    Int J Food Sci Nutr 59:619-34. 2008
    ..Rosmarinus officinalis L., Cuminum cyminum L., Piper nigrum L., Lavandula stoechas spp., Foeniculum vulgare, Pimpinella anisum L...
  35. ncbi Binding of bioactive phytochemical piperine with human serum albumin: a spectrofluorometric study
    Dodda Venkatanna Suresh
    Department of Biochemistry and Nutrition, Central Food Technological Research Institute, Mysore 570 020, Karnataka, India
    Biopolymers 86:265-75. 2007
    Piperine, the bioactive alkaloid compound of the spice black pepper (Piper nigrum) exhibits a wide range of beneficial physiological and pharmacological activities...
  36. ncbi UV irradiation affects melanocyte stimulatory activity and protein binding of piperine
    Amala Soumyanath
    Department of Pharmacy, King s College London, Franklin Wilkins Building, 150 Stamford Street, London SE1 9NN, UK
    Photochem Photobiol 82:1541-8. 2006
    Piperine, the major alkaloid of black pepper (Piper nigrum L.; Piperaceae), stimulates melanocyte proliferation and dendrite formation in vitro. This property renders it a potential treatment for the skin depigmentation disorder vitiligo...
  37. ncbi Analysis of Piperaceae germplasm by HPLC and LCMS: a method for isolating and identifying unsaturated amides from Piper spp extracts
    Ian M Scott
    Biology Department, University of Ottawa, Ottawa, Ontario, K1N 6N5, Canada
    J Agric Food Chem 53:1907-13. 2005
    ..This allows for a rapid and accurate measure of unsaturated amides, or piperamides, in black pepper, Piper nigrum L., and in wild species from Central America...
  38. ncbi [Control in vitro tick (Boophilus microplus; Acari: Ixodidae) through plant extracts]
    Victor Alvarez
    Ministerio de Agricultura y Ganaderia, Servicio Nacional de Salud Animal, San Jose, Costa Rica
    Rev Biol Trop 56:291-302. 2008
    ..The species that produced the highest mortality were Zizigium aromaticum, Morus alba, Piper nigrum and the mixture of Allium sativum- Z. aromaticum (all non-polar); on oviposition: M. alba, P...
  39. ncbi Stability-indicating reversed-phase liquid chromatographic methods for the determination of aconitine and piperine in a polyherbal formulation
    Pallavi Rai
    The Maharaja Sayajirao University of Baroda, Pharmacy Department, Quality Assurance Laboratory, Centre of Relevance and Excellence in Novel Drug Delivery Systems, G H Patel building, Donor s Plaza, Fatehgunj, Vadodara, Gujarat, India
    J AOAC Int 92:1044-54. 2009
    ..of aconitine (ACN) and piperine (PIN) in Mahamrutynjaya rasa, an herbal dosage form containing Aconitum ferox, Piper nigrum, and Piper longum in combination...
  40. ncbi Piperine modulates permeability characteristics of intestine by inducing alterations in membrane dynamics: influence on brush border membrane fluidity, ultrastructure and enzyme kinetics
    A Khajuria
    Manitoba Institute of Cell Biology, Winnipeg, Canada
    Phytomedicine 9:224-31. 2002
    Piperine (1-Piperoyl piperidine) is a major alkaloid of Piper nigrum Linn. and Piper longum Linn. It is shown to possess bioavailability-enhancing activity with various structurally and therapeutically diverse drugs...
  41. ncbi Effects of piperine on gastric acid secretion in albino rats
    I M Ononiwu
    Department of Pharmacology, College of Health Sciences, University of Port Harcourt, Rivers State, Nigeria
    Afr J Med Med Sci 31:293-5. 2002
    Piperine, the pungent principle in Piper nigrum and Piper guinensis was studied for its effect on gastric acid secretion in white albino rats...
  42. ncbi Cytoprotective and immunomodulating properties of piperine on murine splenocytes: an in vitro study
    Neelima Pathak
    Industrial Toxicology Research Centre, Mahatma Gandhi Marg, P Box 80, Lucknow 226001, India
    Eur J Pharmacol 576:160-70. 2007
    Piper longum Linn. and Piper nigrum Linn. are conventionally used as immuno-enhancers in Indian system of traditional medicine. The underlying mechanism remains unknown...
  43. ncbi Screening for acetylcholinesterase inhibitory activity in plants used in Thai traditional rejuvenating and neurotonic remedies
    Kornkanok Ingkaninan
    Department of Pharmaceutical Chemistry and Pharmacognosy, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok 65000, Thailand
    J Ethnopharmacol 89:261-4. 2003
    ..At the same concentration, four extracts, i.e. stems of Piper interruptum Opiz., seeds of Piper nigrum L., rootbarks of Butea superba Roxb. and roots of Cassia fistula L...
  44. ncbi Isolation and amplification of genomic DNA from recalcitrant dried berries of black pepper (Piper nigrum L.)--a medicinal spice
    K Dhanya
    Division of Crop Improvement and Biotechnology, Indian Institute of Spices Research, Calicut, Kerala, 673012, India
    Mol Biotechnol 37:165-8. 2007
    ..The protocol has trade implication as it will help in the PCR characterization of traded black peppers from different countries...
  45. ncbi Effect of piperine on the inhibition of nitric oxide (NO) and TNF-alpha production
    C R Pradeep
    Amala Cancer Research Centre, Thrissur, Kerala, India
    Immunopharmacol Immunotoxicol 25:337-46. 2003
    Effect of piperine which is an alkaloid present in plants such as Piper nigrum and Piper longum on the production of nitric oxide (NO) and tumor necrosis factor-alpha (TNF-alpha) level was analyzed using in vitro as well as in vivo ..
  46. ncbi Comparative study of Rhodiola preparations on behavioral despair of rats
    A Panossian
    Swedish Herbal Institute Research and Development, Spårvägen 2, SE 432 96 Askloster, Sweden
    Phytomedicine 15:84-91. 2008
    ..RPE cannot provide predictable therapeutic effect due to herb-herb interaction. Moreover, concomitant treatment of RPE with other drugs should also be excluded due to drug-piperine interaction...
  47. doi Piperine, the main alkaloid of Thai black pepper, protects against neurodegeneration and cognitive impairment in animal model of cognitive deficit like condition of Alzheimer's disease
    Pennapa Chonpathompikunlert
    Department of Physiology and Graduate School, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
    Food Chem Toxicol 48:798-802. 2010
    ..Based on this information, the effect of piperine, a main active alkaloid in fruit of Piper nigrum, on memory performance and neurodegeneration in animal model of Alzheimer's disease have been investigated...
  48. ncbi In vivo effect of piperine on serum and tissue glycoprotein levels in benzo(a)pyrene induced lung carcinogenesis in Swiss albino mice
    K Selvendiran
    Department of Medical Biochemistry, Dr ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai, India
    Pulm Pharmacol Ther 19:107-11. 2006
    ..Piperine is a pure, pungent alkaloid constituent of black and long peppers (Piper nigrum and Piper longum), that acts as an antioxidant and anticancer agent by its numerous macromolecules associated ..
  49. ncbi Cloning, DNA sequence, and expression of Aeromonas caviae WS7b chitinase gene
    Amarila Malik
    South East Asian Regional Center for Tropical Biology SEAMEO BIOTROP, Jl Raya Tajur Km 6, Bogor, Indonesia
    Mol Biotechnol 23:1-10. 2003
    ..The ability of the chitinase cloned in E. coli to hydrolyze chitin was less than that of the enzyme in its indigenous host...
  50. ncbi Adsorption and removal kinetics of phosphonate from water using natural adsorbents
    R Anil Kumar
    Department of Science and Humanities, National Institute of Technology Calicut, Kozhikode, Kerala, India
    Water Environ Res 82:62-8. 2010
    ..phosphonate is a fungicide used for the control of Phytophthora capsici, which is prevalent in black pepper (Piper nigrum L.). Batch adsorption kinetic experiments were conducted on the adsorption of phosphonate onto the adsorbents...
  51. ncbi Evidence that the nonstructural protein of Tomato spotted wilt virus is the avirulence determinant in the interaction with resistant pepper carrying the TSW gene
    P Margaria
    Istituto di Virologia Vegetale, Sez di Torino, CNR, Strada delle Cacce 73, Torino 10135, Italy
    Mol Plant Microbe Interact 20:547-58. 2007
    ..Analysis of another RB strain phenotype allowed us to conclude that local necrotic response is not sufficient for resistance in Capsicum spp. carrying the Tsw gene...
  52. ncbi Phytochemical studies on the seed extract of Piper nigrum Linn
    Munawwer Rasheed
    H E J Research Institute of Chemistry, International Centre for Chemical Sciences, University of Karachi, Karachi 75270, Pakistan
    Nat Prod Res 19:703-12. 2005
    The petroleum ether extract of dried ground seeds of Piper nigrum Linn...
  53. ncbi Protection of stored maize against Sitophilus zeamais (Motsch.) by use of essential oils of spices from Cameroon
    L S Ngamo
    Faculty of Sciences, Department of Biological Sciences, , P.O. Box 454, , Cameroon
    Meded Rijksuniv Gent Fak Landbouwkd Toegep Biol Wet 66:473-8. 2001
    ..Lamiaceae) 74% after 4 days after ingestion. Piper nigrum (L.) (Piperaceae) killing more than 96% of weevil 48 hours after the contact...
  54. ncbi Molecular target of piperine in the inhibition of lipid droplet accumulation in macrophages
    Daisuke Matsuda
    Graduate School of Pharmacy, Kitasato University, Shirokane, Tokyo, Japan
    Biol Pharm Bull 31:1063-6. 2008
    An alkaloid piperine isolated from the Piper Nigrum was found to inhibit lipid droplet accumulation in mouse macrophages, and especially inhibited cholesteryl ester (CE) synthesis (IC50: 25 microM)...
  55. ncbi Piperine, the potential functional food for mood and cognitive disorders
    Jintanaporn Wattanathorn
    Department of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
    Food Chem Toxicol 46:3106-10. 2008
    The effect of piperine, the main alkaloid from piper nigrum, on the central nervous system is not clearly known until now...
  56. pmc Studies on effect of piperine on oral bioavailability of ampicillin and norfloxacin
    Kunchithapatham Janakiraman
    Kunchithapatham Janakiraman, Selection Grade Lecturer, Department of Pharmacy, Annamalai University, Annamalainagar, Tamil Nadu, India
    Afr J Tradit Complement Altern Med 5:257-62. 2008
    ..These two drugs have low oral bioavailability. Co-administration of Piperine (20mg/kg), an alkaloid from Piper nigrum L. enhanced oral bioavailability of Ampicillin and Norfloxacin in animal model...
  57. ncbi [Potential allelopathic effects of Piper nigrum, Mangifera indica and Clausena lansium]
    Guijun Yan
    College of Environment and Plant Protection, South China University of Tropical Agriculture, Danzhou, China
    Ying Yong Sheng Tai Xue Bao 17:1633-6. 2006
    With Piper nigrum, Mangifera indica and Clausena lansium as the donators, this paper studied their potential allelopathic effects on the germination and growth of Zea mays, Glycine max, Cucurbita moschata, Arachis hypogaea, Raphanus ..
  58. doi Microwave-assisted synthesis of N-isobutyl-4,5-epoxy-2(E)-decenamide
    Neeraj Gupta
    Department of Chemistry and Centre of Advanced Studies in Chemistry, Panjab University, Chandigarh 160014, India
    Nat Prod Res 27:548-53. 2013
    ..of a naturally occurring amide alkaloid, N-isobutyl-4,5-epoxy-2(E)-decenamide isolated from the roots of Piper nigrum has been described involving a total of nine steps...
  59. pmc GABAA receptor modulation by piperine and a non-TRPV1 activating derivative
    Sophia Khom
    Department of Pharmacology and Toxicology, University of Vienna, Althanstraße 14, A 1090 Wien, Austria
    Biochem Pharmacol 85:1827-36. 2013
    ....
  60. ncbi Antioxidant activity of a salt-spice-herbal mixture against free radical induction
    Kavithalakshmi S Natarajan
    ALMPG Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai 600113, India
    J Ethnopharmacol 105:76-83. 2006
    A combination of spices (Piper nigrum, Piper longum and Zingiber officinale), herbs (Cyperus rotundus and Plumbago zeylanica) and salts make up Amrita Bindu...
  61. pmc Chemical composition and fatty acid content of some spices and herbs under Saudi Arabia conditions
    Fahad Mohammed Al-Jasass
    General Directorate of Research Grants, King Abdulaziz City for Science and Technology, P O Box 6086, Riyadh 11442, Saudi Arabia
    ScientificWorldJournal 2012:859892. 2012
    ..The differences in the results obtained are due to environmental factors, production areas, cultivars used to produce seeds and also due to the different methods used to prepare these local spices...
  62. pmc In vitro antibacterial and antibiotic-potentiation activities of four edible plants against multidrug-resistant gram-negative species
    Jaures A K Noumedem
    Department of Biochemistry, Faculty of Science, University of Dschang, Dschang, Cameroon
    BMC Complement Altern Med 13:190. 2013
    ....
  63. ncbi Element analysis and biological studies on ten oriental spices using XRF and Ames test
    Barakat A Al-Bataina
    Physics Department, Yarmouk University, Irbid, Jordan
    J Trace Elem Med Biol 17:85-90. 2003
    ..tinctorius), caraway (Carum carvi), Sicilian sumac (Rhus coriaria), aniseed (Anisum vulgare), black pepper (Piper nigrum), cardamom (Elettaria cardamomum), cumin (Cuminum cyminum) and nigella (Nigella sativum)...
  64. doi Structural and sensory characterization of key pungent and tingling compounds from black pepper (Piper nigrum L.)
    Corinna Dawid
    Chair for Food Chemistry and Molecular Sensory Science, Technische Universitat Munchen, Lise Meitner Strasse 34, D 85354 Freising, Germany
    J Agric Food Chem 60:2884-95. 2012
    ..pungent and tingling oral impression imparted by black pepper, an ethanol extract prepared from black pepper (Piper nigrum L.) was screened for its key sensory-active nonvolatiles by application of taste dilution analysis (TDA)...
  65. doi Microsatellite based analysis of genetic diversity of popular black pepper genotypes in South India
    Nisha Joy
    Plant Molecular Biology Lab, Rajiv Gandhi Centre for Biotechnology, Poojappura, Thiruvananthapuram 695014, India
    Genetica 139:1033-43. 2011
    ..The study was first to portray the precise genetic relatedness among the major indigenous genotypes of black pepper...
  66. doi Antioxidant and anti-atherogenic activities of three Piper species on atherogenic diet fed hamsters
    Gabriel A Agbor
    Institute of Medical Research and Medicinal Plants Studies, PO Box 6163, Yaounde, Cameroon
    Exp Toxicol Pathol 64:387-91. 2012
    ..aims at evaluating the antioxidant and anti-atherosclerotic activities of three Piper species (Piper guineense, Piper nigrum and Piper umbellatum) on atherogenic diet fed hamsters...
  67. doi Identification of an miRNA candidate reflects the possible significance of transcribed microsatellites in the hairpin precursors of black pepper
    Nisha Joy
    Plant Molecular Biology, Rajiv Gandhi Centre for Biotechnology, Thycaud P O, Poojappura, Thiruvananthapuram, 695 014 Kerala, India
    Funct Integr Genomics 12:387-95. 2012
    ..genes, we carried out a preliminary analysis to verify the presence of SSRs in the pri-miRNAs of black pepper (Piper nigrum L.). We isolated a (CT) dinucleotide SSR bearing transcript using SMART strategy...
  68. doi Protein tyrosine phosphatase 1B inhibitory activity of Indonesian herbal medicines and constituents of Cinnamomum burmannii and Zingiber aromaticum
    Azis Saifudin
    Institute of Natural Medicine, University of Toyama, Toyama, Japan
    J Nat Med 67:264-70. 2013
    ..leaf, Blumea balsamifera, Cinnamomum burmannii, Cymbopogon nardus, Melaleuca leucadendra, Phyllanthus niruri, Piper nigrum, Syzygium aromaticum, and Sy...
  69. ncbi Effect of some medicinal plant extracts on the oxidative stress status in Alzheimer's disease induced in rats
    K Mahdy
    Department of Medical Biochemistry, National Research Center, Cairo University, Cairo, Egypt
    Eur Rev Med Pharmacol Sci 16:31-42. 2012
    ..The present study aims to investigate the effect of Salvia triloba and Piper nigrum plant extracts on the oxidative stress status in Alzheimer's disease induced in rats.
  70. pmc High-throughput sequencing of black pepper root transcriptome
    Sheila M C Gordo
    Genetics and Molecular Biology Laboratory, COASTAL STUDIES INSTITUTE, Bragança Campus, Universidade Federal do Para, PA, Brazil
    BMC Plant Biol 12:168. 2012
    Black pepper (Piper nigrum L.) is one of the most popular spices in the world. It is used in cooking and the preservation of food and even has medicinal properties...
  71. pmc In vivo effect of some home spices extracts on the toxoplasma gondii tachyzoites
    Najia A Al-Zanbagi
    Biology Department, Science College, King Abdulaziz University, Jeddah, Saudi Arabia
    J Family Community Med 16:59-65. 2009
    ..The anti-toxoplasmic activity of water and ethanol extracts as well as the oil of some home spices (Piper nigrum, Capsicum frutescens, Cinnamomum cassia and Curcuma longa), were evaluated in murine models of intraperitoneal ..
  72. ncbi Evaluation of the effect of piperine per se on blood glucose level in alloxan-induced diabetic mice
    Shubham Atal
    Department of Pharmacology, M G M Medical College, Indore, M P 452001, India corrected
    Acta Pol Pharm 69:965-9. 2012
    ..Piperine, the chief alkaloid present in Piper nigrum (black pepper), has a wide array of uses in alternative and complementary therapies...
  73. doi Influence of extraction solvents on antioxidant activity and the content of bioactive compounds in non-pungent peppers
    Haejin Bae
    Vegetable and Fruit Improvement Center, Department of Horticultural Sciences, Texas A and M University, College Station, TX, USA
    Plant Foods Hum Nutr 67:120-8. 2012
    ....
  74. ncbi Pharmacokinetic herb-drug interactions (part 2): drug interactions involving popular botanical dietary supplements and their clinical relevance
    Bill J Gurley
    Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, College of Pharmacy, Little Rock, AR 72205, USA
    Planta Med 78:1490-514. 2012
    ..g., Hydrastis canadensis, Piper nigrum, Schisandra chinensis) or function as ligands for orphan nuclear receptors (e.g., Hypericum perforatum)...
  75. doi Piperine inhibits PMA-induced cyclooxygenase-2 expression through downregulating NF-κB, C/EBP and AP-1 signaling pathways in murine macrophages
    Hyung Gyun Kim
    Department of Toxicology, College of Pharmacy, Chungnam National University, Daejeon, Republic of Korea
    Food Chem Toxicol 50:2342-8. 2012
    Piperine is a major component of black (Piper nigrum Linn) and long (Piper longum Linn) peppers, and is widely used as a traditional food and medicine...
  76. ncbi Analysis of the blackening of green pepper (Piper nigrum Linnaeus) berries
    Fenglin Gu
    Spice and Beverage Research Institute, CATAS, Wanning, Hainan 571533, China
    Food Chem 138:797-801. 2013
    ..activity, reduced weight percentage after sun drying, and the changes in colour and appearance of green pepper (Piper nigrum Linnaeus) berries after blanching and sun drying...
  77. pmc HPLC-based activity profiling: discovery of piperine as a positive GABA(A) receptor modulator targeting a benzodiazepine-independent binding site
    Janine Zaugg
    Institute of Pharmaceutical Biology, University of Basel, Klingelbergstrasse 50, 4056 Basel, Switzerland
    J Nat Prod 73:185-91. 2010
    ..An ethyl acetate extract of black pepper fruits [Piper nigrum L...
  78. ncbi Tissue distribution & elimination of capsaicin, piperine & curcumin following oral intake in rats
    D Suresh
    Department of Biochemistry and Nutrition, Central Food Technological Research Institute CSIR, Mysore, India
    Indian J Med Res 131:682-91. 2010
    ..bioactive compounds present in spices--turmeric (Curcuma longa), red pepper (Capsicum annuum) and black pepper (Piper nigrum) respectively, have a considerable portion of structural homology...
  79. ncbi Neuroprotective effect of piperine on primarily cultured hippocampal neurons
    Min Fu
    Medical College, Tsinghua University, China
    Biol Pharm Bull 33:598-603. 2010
    ..These data suggest that the neuroprotective effects of PIP might be associated with suppression of synchronization of neuronal networks, presynaptic glutamic acid release, and Ca(2+) overloading...
  80. doi The plant alkaloid piperine as a potential inhibitor of ethidium bromide efflux in Mycobacterium smegmatis
    Jing Jin
    Key Laboratory of Zoonosis Research, Ministry of Education, Institute of Zoonosis, College of Animal Science and Veterinary Medicine, Jilin University, Changchun 130062, PR China
    J Med Microbiol 60:223-9. 2011
    Piperine, a major plant alkaloid found in black pepper (Piper nigrum) and long pepper (Piper longum), has shown potential for inhibiting the efflux pump (EP) of Staphylococcus aureus...
  81. ncbi High-frequency plant regeneration through cyclic secondary somatic embryogenesis in black pepper (Piper nigrum L.)
    R Ramakrishnan Nair
    Indian Institute of Spices Research, Calicut, 673012, Kerala, India
    Plant Cell Rep 24:699-707. 2006
    A high-frequency plantlet regeneration protocol was developed for black pepper (Piper nigrum L.) through cyclic secondary somatic embryogenesis...
  82. ncbi Characterisation of Phytophthora capsici isolates from black pepper in Vietnam
    Nguyen V Truong
    School of Agriculture and Forestry, Hue University, 102 Phung Hung Street, Hue City, Viet Nam
    Fungal Biol 114:160-70. 2010
    Phytophthora foot rot of black pepper caused by Phytophthora capsici is a major disease of black pepper (Piper nigrum) throughout Vietnam. To understand the population structure of P. capsici, a large collection of P...
  83. ncbi Identifying sequences potentially related to resistance response of Piper tuberculatum to Fusarium solani f. sp. piperis by suppression subtractive hybridization
    Soelange Bezerra Nascimento
    Laboratorio de Biologia Molecular, Universidade Federal do Para, Belem PA, Brazil
    Protein Pept Lett 16:1429-34. 2009
    ..sp. piperis, causal agent of Fusarium disease in black pepper (Piper nigrum L.). In this work we aimed to study the interaction between P. tuberculatum and F. solani f. sp...
  84. ncbi [Allelopathy of decomposing pepper stalk on pepper growth]
    Yongxia Hou
    College of Horticulture, Shenyang Agricultural University, Shenyang 110161, China
    Ying Yong Sheng Tai Xue Bao 17:699-702. 2006
    ..The allelopathic effects of decomposed pepper stalk on the physiological indices of pepper root activity ranged from 0.0163 to 0.6507, which was significantly higher than that of plant growth index...
  85. ncbi Histamine release inhibitory activity of Piper nigrum leaf
    Noriko Hirata
    School of Pharmacy, Kinki University, 3 4 1 Kowakae, Higashiosaka, Osaka 577 8502, Japan
    Biol Pharm Bull 31:1973-6. 2008
    Oral administration of a methanolic extract of Piper nigrum leaf (PN-ext, 50, 200 and 500 mg/kg) showed a potent dose-dependent inhibition of dinitrofluorobenzene (DNFB)-induced cutaneous reaction at 1 h [immediate phase response (IPR)] ..
  86. doi Inhibition of lipopolysaccharide-induced inflammatory responses by piperine
    Gi Sang Bae
    Department of Herbology, School of Oriental Medicine, Wonkwang University, Iksan, 540 749 Jeonbuk, South Korea
    Eur J Pharmacol 642:154-62. 2010
    Piperine, a main component of Piper longum Linn. and Piper nigrum Linn., is a plant alkaloid with a long history of medical use. Piperine exhibits anti-inflammatory activity; however, the underlying mechanism remains unknown...
  87. doi Immunomodulatory role of piperine in cadmium induced thymic atrophy and splenomegaly in mice
    Neelima Pathak
    Indian Institute of Toxicology Research, Mahatma Gandhi Marg, P Box 80, Lucknow 226001, Uttar Pradesh, India
    Environ Toxicol Pharmacol 28:52-60. 2009
    ..Piperine, major alkaloid of Piper longum Linn. and Piper nigrum Linn. with a long history of medicinal value, has shown anti-apoptotic activity in vitro...
  88. doi Mediation of cholino-piperine like receptors by extracts of Piper nigrum induces melanin dispersion in Rana tigerina tadpole melanophores
    Mohammed Sajid
    Postgraduate Department of Biotechnology, Saifia College of Science, Bhopal, India
    J Recept Signal Transduct Res 31:286-90. 2011
    The present study was carried out to determine the effects of lyophilized dried fruit extracts of Piper nigrum and pure piperine on the tadpole melanophores of frog Rana tigerina which offer excellent in vitro opportunities for studying ..
  89. doi Effect of enzyme activity and frozen storage on jalapeño pepper volatiles by selected ion flow tube-mass spectrometry
    Carolina Azcarate
    Dept of Food Science and Technology, The Ohio State Univ, 2015 Fyffe Rd, Columbus, Ohio 43210, USA
    J Food Sci 75:C710-21. 2010
    ..The compounds (E,Z)-2,6-nonadienal, n-propyl aldehyde, 2-isobutyl-3-methoxypyrazine, and a mixture of terpenes decreased in unblanched and blanched frozen samples, while nonanal and methylbutanal increased only in unblanched samples...
  90. doi The effect of chemical treatment on reduction of aflatoxins and ochratoxin A in black and white pepper during washing
    M Jalili
    Centre of Excellence for Food Safety Research, Department of Food Technology, Faculty of Food Science and Technology, Universiti Putra Malaysia, Serdang, Selangor, Malaysia
    Food Addit Contam Part A Chem Anal Control Expo Risk Assess 28:485-93. 2011
    ..5% ± 2.7% using benzoic acid and 54.5% ± 2.7% using sodium hydroxide. There was no significant difference between black and white peppers (p < 0.05)...
  91. ncbi Liquid chromatographic method for determination of piperine in rat plasma: application to pharmacokinetics
    Sunil Bajad
    Pharmacology Division, Regional Research Laboratory, Canal Road, Jammu 180 001, India
    J Chromatogr B Analyt Technol Biomed Life Sci 776:245-9. 2002
    Piperine, a major alkaloid of Piper longum and Piper nigrum has been reported to have several pharmacological/toxicological effects...
  92. ncbi Characterization and control of endophytic bacterial contaminants in in vitro cultures of Piper spp., Taxus baccata subsp. wallichiana, and Withania somnifera
    Anjali A Kulkarni
    Institute of Bioinformatics and Biotechnology, University of Pune, India
    Can J Microbiol 53:63-74. 2007
    ..The five endophytic bacteria associated with Piper nigrum and Piper colubrinum, four endophytic bacteria associated with Taxus baccata subsp...
  93. ncbi Effect of storage on the essential oil composition of Piper nigrum L. fruits of different ripening states
    Anne Orav
    Institute of Chemistry, Faculty of Science, Tallinn Technical University, Ehitajate tee 5, Tallinn 19086, Estonia
    J Agric Food Chem 52:2582-6. 2004
    ..Differently from other pepper samples, 1 year storage of green pepper corn raised the oil amount more than twice of both drying methods...
  94. pmc Effect of trikatu pretreatment on the pharmacokinetics of pefloxacin administered orally in mountain Gaddi goats
    Madhukar S Dama
    Department of Pharmacology and Toxicology, College of Veterinary and Animal Sciences, CSK Himachal Pradesh Agricultural University, Palampur 176 062, Himachal Pradesh, India
    J Vet Sci 9:25-9. 2008
    ..21 mg/kg is required to be administered at 8 h intervals. For practical purposes in goats this would mean a priming dose of 6 mg/kg and a maintenance dose of 2 mg/kg given by the oral route, to be repeated at 8 h intervals...
  95. ncbi Larvicidal activity of isobutylamides identified in Piper nigrum fruits against three mosquito species
    Il Kwon Park
    School of Agricultural Biotechnology, Seoul National University, Suwon 441 744, Republic of Korea
    J Agric Food Chem 50:1866-70. 2002
    The insecticidal activity of materials derived from the fruits of Piper nigrum against third instar larvae of Culex pipiens pallens, Aedes aegypti, and A...
  96. ncbi Antimutagenic effects of piperine on cyclophosphamide-induced chromosome aberrations in rat bone marrow cells
    Sareeya Wongpa
    Toxicology Graduate Programme, Faculty of Science, Mahidol University, Bangkok, Thailand
    Asian Pac J Cancer Prev 8:623-7. 2007
    Piperine is a major pungent substance and active component of black pepper (Piper nigrum Linn.) and long pepper (Piper longum Linn.). Both plants are used worldwide as household spices and condiments...
  97. doi Two new amides with cytotoxic activity from the fruits of Piper longum
    Priyanka Mishra
    Department of Biotechnology, Amity Institute of Biotechnology, Amity University, Noida, India
    J Asian Nat Prod Res 13:143-8. 2011
    ..The structures were elucidated on the basis of spectroscopic evidences. All these compounds inhibited cell proliferation of human leukemia, HL-60 cell lines, and displayed major apoptosis-inducing effects...
  98. ncbi Larvicidal potential of ethanolic extracts of dried fruits of three species of peppercorns against different instars of an indian strain of dengue fever mosquito, Aedes aegypti L. (Diptera: Culicidae)
    Sarita Kumar
    Department of Zoology, Acharya Narendra Dev College University of Delhi, Kalka Ji, New Delhi, 110019, India
    Parasitol Res 107:901-7. 2010
    ..Black pepper, Piper nigrum, and White pepper, Piper nigrum against the different instars of field-collected Indian strain of dengue fever ..
  99. doi Method development and validation for determination of thiosultap sodium, thiocyclam, and nereistoxin in pepper matrix
    C Ferrer
    Community Reference Laboratory DG SANCO for Residues of Pesticides in Fruits and Vegetables, Pesticide Residue Research Group, Department of Hydrogeology and Analytical Chemistry, University of Almeria, 04120 La Cañada de San Urbano, Almeria, Spain
    Anal Bioanal Chem 398:2299-306. 2010
    ..Stability studies of thiosultap sodium in water were performed by evaluating a 100-μg∙l(-1) solution of this compound in water. It was analyzed over 7 days, after which more than 80% degradation of thiosultap sodium could be observed...
  100. ncbi Effects of a nutritional supplement on periodontal status
    C A Munoz
    Center for Dental Research, Loma Linda University, School of Dentistry, Loma Linda, California, USA
    Compend Contin Educ Dent 22:425-8, 430, 432 passim; quiz 440. 2001
    ..The results of the present study suggest that a multi-vitamin nutritional supplement might be a beneficial adjunct to the required established periodontal treatment...
  101. ncbi Detection of Tobacco mosaic virus and Tomato mosaic virus in pepper and tomato by multiplex RT-PCR
    S Kumar
    Department of Studies in Biotechnology, University of Mysore, Manasagangotri, Mysore, 570006 Karnataka, India
    Lett Appl Microbiol 53:359-63. 2011
    ..In this study, we use the multiplex PCR technique to detect dual infection of these two viruses...

Research Grants3

  1. Clinical Assessment of Herb-Drug Interactions
    Bill Gurley; Fiscal Year: 2003
    ..e. CYPIA2, CYP2D6 and CYP3A4); and (3) whether prolonged herb use can modulate P-gp-mediated drug absorption and elimination. ..
  2. Clinical Assessment of Herb-Drug Interactions
    Bill Gurley; Fiscal Year: 2004
    ..e. CYPIA2, CYP2D6 and CYP3A4); and (3) whether prolonged herb use can modulate P-gp-mediated drug absorption and elimination. ..
  3. Clinical Assessment of Herb-Drug Interactions
    Bill Gurley; Fiscal Year: 2005
    ..e. CYPIA2, CYP2D6 and CYP3A4); and (3) whether prolonged herb use can modulate P-gp-mediated drug absorption and elimination. ..