piper nigrum

Summary

Summary: A plant species in the PIPERACEAE plant family. It is a common spice on foods and is used medicinally to increase gastrointestinal assimilation of other supplements and drugs. PIPERINE is a key component. Black pepper is picked unripe and heaped for a few days to ferment. White Pepper is the ripe fruit dehulled by maceration in water.

Top Publications

  1. ncbi A rapid method for isolation of piperine from the fruits of Piper nigrum Linn
    Niranjan Kanaki
    Department of Phytochemistry and Pharmacognosy, B V Patel Pharmaceutical Education and Research Development Centre, Thaltej Gandhinagar Highway, Thaltej, Ahmedabad, 380 054, Gujarat, India
    J Nat Med 62:281-3. 2008
  2. ncbi Antioxidant efficacy of black pepper (Piper nigrum L.) and piperine in rats with high fat diet induced oxidative stress
    R S Vijayakumar
    Department of Biochemistry, Annamalai University, Annamalai Nagar, Tamilnadu, India
    Redox Rep 9:105-10. 2004
  3. ncbi Amides from Piper nigrum L. with dissimilar effects on melanocyte proliferation in-vitro
    Zhixiu Lin
    Department of Pharmacy, King s College London, 150 Stamford Street, London SE1 9NN, UK
    J Pharm Pharmacol 59:529-36. 2007
  4. ncbi Endophytic bacterial flora in root and stem tissues of black pepper (Piper nigrum L.) genotype: isolation, identification and evaluation against Phytophthora capsici
    R Aravind
    Indian Institute of Spices Research, Calicut, Kerala, India
    Lett Appl Microbiol 48:58-64. 2009
  5. ncbi Piperine, a piperidine alkaloid from Piper nigrum re-sensitizes P-gp, MRP1 and BCRP dependent multidrug resistant cancer cells
    Sen Li
    College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300071, People s Republic of China
    Phytomedicine 19:83-7. 2011
  6. ncbi In vitro investigation of the potential immunomodulatory and anti-cancer activities of black pepper (Piper nigrum) and cardamom (Elettaria cardamomum)
    Amin F Majdalawieh
    Department of Biology and Chemistry, Faculty of Arts and Sciences, American University of Sharjah, Sharjah, United Arab Emirates
    J Med Food 13:371-81. 2010
  7. ncbi Pellitorine, a potential anti-cancer lead compound against HL6 and MCT-7 cell lines and microbial transformation of piperine from Piper Nigrum
    Gwendoline Cheng Lian Ee
    Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, Selangor, Malaysia
    Molecules 15:2398-404. 2010
  8. ncbi Inhibitory effects of black pepper (Piper nigrum) extracts and compounds on human tumor cell proliferation, cyclooxygenase enzymes, lipid peroxidation and nuclear transcription factor-kappa-B
    Yunbao Liu
    Bioactive Natural Products and Phytoceuticals, Department of Horticulture and National Food Safety and Toxicology Center, Michigan State University, East Lansing, Michigan 48824, USA
    Nat Prod Commun 5:1253-7. 2010
  9. pmc Antibacterial activity of natural spices on multiple drug resistant Escherichia coli isolated from drinking water, Bangladesh
    Shahedur Rahman
    Department of Biotechnology and Genetic Engineering, Islamic University, Kushtia, Bangladesh
    Ann Clin Microbiol Antimicrob 10:10. 2011
  10. ncbi Chemistry and in vitro antioxidant activity of volatile oil and oleoresins of black pepper (Piper nigrum)
    I P S Kapoor
    Chemistry Department, DDU Gorakhpur University, Gorakhpur, India
    J Agric Food Chem 57:5358-64. 2009

Research Grants

  1. Clinical Assessment of Herb-Drug Interactions
    Bill Gurley; Fiscal Year: 2005

Detail Information

Publications155 found, 100 shown here

  1. ncbi A rapid method for isolation of piperine from the fruits of Piper nigrum Linn
    Niranjan Kanaki
    Department of Phytochemistry and Pharmacognosy, B V Patel Pharmaceutical Education and Research Development Centre, Thaltej Gandhinagar Highway, Thaltej, Ahmedabad, 380 054, Gujarat, India
    J Nat Med 62:281-3. 2008
    A simple, rapid and efficient method has been developed for the isolation of piperine from the fruits of Piper nigrum. The method involves extraction of the fruit powder with glacial acetic acid, from which piperine is partitioned into ..
  2. ncbi Antioxidant efficacy of black pepper (Piper nigrum L.) and piperine in rats with high fat diet induced oxidative stress
    R S Vijayakumar
    Department of Biochemistry, Annamalai University, Annamalai Nagar, Tamilnadu, India
    Redox Rep 9:105-10. 2004
    The present study was aimed to explore the effect of black pepper (Piper nigrum L.) on tissue lipid peroxidation, enzymic and non-enzymic antioxidants in rats fed a high-fat diet...
  3. ncbi Amides from Piper nigrum L. with dissimilar effects on melanocyte proliferation in-vitro
    Zhixiu Lin
    Department of Pharmacy, King s College London, 150 Stamford Street, London SE1 9NN, UK
    J Pharm Pharmacol 59:529-36. 2007
    ..b>Piper nigrum L...
  4. ncbi Endophytic bacterial flora in root and stem tissues of black pepper (Piper nigrum L.) genotype: isolation, identification and evaluation against Phytophthora capsici
    R Aravind
    Indian Institute of Spices Research, Calicut, Kerala, India
    Lett Appl Microbiol 48:58-64. 2009
    To isolate and identify black pepper (Piper nigrum L) associated endophytic bacteria antagonistic to Phytophthora capsici causing foot rot disease.
  5. ncbi Piperine, a piperidine alkaloid from Piper nigrum re-sensitizes P-gp, MRP1 and BCRP dependent multidrug resistant cancer cells
    Sen Li
    College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300071, People s Republic of China
    Phytomedicine 19:83-7. 2011
    ..These results suggest that piperine can reverse MDR by multiple mechanisms and it may be a promising lead compound for future studies...
  6. ncbi In vitro investigation of the potential immunomodulatory and anti-cancer activities of black pepper (Piper nigrum) and cardamom (Elettaria cardamomum)
    Amin F Majdalawieh
    Department of Biology and Chemistry, Faculty of Arts and Sciences, American University of Sharjah, Sharjah, United Arab Emirates
    J Med Food 13:371-81. 2010
    ..We anticipate that black pepper and cardamom constituents can be used as potential therapeutic tools to regulate inflammatory responses and prevent/attenuate carcinogenesis...
  7. ncbi Pellitorine, a potential anti-cancer lead compound against HL6 and MCT-7 cell lines and microbial transformation of piperine from Piper Nigrum
    Gwendoline Cheng Lian Ee
    Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, Selangor, Malaysia
    Molecules 15:2398-404. 2010
    Pellitorine (1), which was isolated from the roots of Piper nigrum, showed strong cytotoxic activities against HL60 and MCT-7 cell lines...
  8. ncbi Inhibitory effects of black pepper (Piper nigrum) extracts and compounds on human tumor cell proliferation, cyclooxygenase enzymes, lipid peroxidation and nuclear transcription factor-kappa-B
    Yunbao Liu
    Bioactive Natural Products and Phytoceuticals, Department of Horticulture and National Food Safety and Toxicology Center, Michigan State University, East Lansing, Michigan 48824, USA
    Nat Prod Commun 5:1253-7. 2010
    Black pepper (Piper nigrum) and hot pepper (Capsicum spp.) are widely used in traditional medicines. Although hot Capsicum spp...
  9. pmc Antibacterial activity of natural spices on multiple drug resistant Escherichia coli isolated from drinking water, Bangladesh
    Shahedur Rahman
    Department of Biotechnology and Genetic Engineering, Islamic University, Kushtia, Bangladesh
    Ann Clin Microbiol Antimicrob 10:10. 2011
    ..The present work aimed to find out the antimicrobial activity of natural spices on multi-drug resistant Escherichia coli isolates...
  10. ncbi Chemistry and in vitro antioxidant activity of volatile oil and oleoresins of black pepper (Piper nigrum)
    I P S Kapoor
    Chemistry Department, DDU Gorakhpur University, Gorakhpur, India
    J Agric Food Chem 57:5358-64. 2009
    Essential oil and oleoresins (ethanol and ethyl acetate) of Piper nigrum were extracted by using Clevenger and Soxhlet apparatus, respectively...
  11. ncbi ACAT inhibition of alkamides identified in the fruits of Piper nigrum
    Mun Chual Rho
    Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology, 52 Eoundong, Yusong gu, Daejon 305 333, Republic of Korea
    Phytochemistry 68:899-903. 2007
    In this study, via a bioactivity-guided fractionation of MeOH extracts of the fruits of Piper nigrum, alkamide (5) and five previously-identified alkamides were isolated...
  12. ncbi Alkamides from the fruits of Piper longum and Piper nigrum displaying potent cell adhesion inhibition
    Seung Woong Lee
    Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 305 806, Republic of Korea
    Bioorg Med Chem Lett 18:4544-6. 2008
    ..Their compounds 3-5, 7, and 8 inhibited potently the direct binding between sICAM-1 and LFA-1 of THP-1 cells in a dose-dependent manner, with IC(50) values of 10.7, 8.8, 13.4, 13.5, and 6.0 microg/mL, respectively...
  13. ncbi Melanogenesis stimulation in murine B16 melanoma cells by Piper nigrum leaf extract and its lignan constituents
    Hideaki Matsuda
    School of Pharmaceutical Sciences, Kinki University, Higashiosaka, Osaka, Japan
    Biol Pharm Bull 27:1611-6. 2004
    A methanolic extract from the leaves of Piper nigrum L. showed a significant stimulatory effect on melanogenesis in cultured murine B16 melanoma cells...
  14. ncbi Nigramides A-S, dimeric amide alkaloids from the roots of Piper nigrum
    Kun Wei
    Faculty of Pharmaceutical Sciences, Toho University, Miyama 2 2 1, Funabashi, Chiba 274 8510, Japan
    J Org Chem 70:1164-76. 2005
    ..amide alkaloids possessing a cyclobutane ring, nigramides P-S (17-20), have been isolated from the roots of Piper nigrum. Their structures were elucidated on the basis of their spectroscopic data...
  15. ncbi Protective effects of Piper nigrum and Vinca rosea in alloxan induced diabetic rats
    M Kaleem
    Department of Biochemistry, Faculty of Life Sciences, AMU, Aligarh 202 002
    Indian J Physiol Pharmacol 49:65-71. 2005
    In the present study aqueous extract of Piper nigrum seeds and Vinca rosea flowers were administered orally to alloxan induced diabetic rats once a day for 4 weeks...
  16. ncbi The effect of a synergistic concentration of a Piper nigrum extract used in conjunction with pyrethrum upon gene expression in Drosophila melanogaster
    H R Jensen
    Department of Biology, University of Ottawa, Center for Advanced Research in Environmental Genomics, Ottawa, Ontario, Canada
    Insect Mol Biol 15:329-39. 2006
    An ethyl acetate extract of Piper nigrum L. (Piperaceae) peppercorns was tested as a synergist for the botanical insecticide pyrethrum. A high synergist ratio of 11...
  17. ncbi Mechanism-based inhibition of human liver microsomal cytochrome P450 2D6 (CYP2D6) by alkamides of Piper nigrum
    - Subehan
    Institute of Natural Medicine, University of Toyama, Toyama, Japan
    Planta Med 72:527-32. 2006
    Nineteen alkamides isolated from Piper nigrum L. were tested for their mechanism-based inhibition on human liver microsomal dextromethorphan O-demethylation activity, a prototype marker for cytochrome P450 2D6 (CYP2D6)...
  18. ncbi Repellent activity of essential oils against cockroaches (Dictyoptera: Blattidae, Blattellidae, and Blaberidae) in Thailand
    Usavadee Thavara
    National Institute of Health, Department of Medical Sciences, Ministry of Public Health, Nonthaburi, Thailand
    Southeast Asian J Trop Med Public Health 38:663-73. 2007
    ..Mansf., Citrus hystrix DC., Curcuma longa L., Litsea cubeba (Lour.) Pers., Piper nigrum L., Psidium guajava L...
  19. ncbi Antibacterial constituents from the berries of Piper nigrum
    S Venkat Reddy
    Natural Product Laboratory, Indian Institute of Chemical Technology, Hyderabad 500 007, India
    Phytomedicine 11:697-700. 2004
    b>Piper nigrum finds an extensive application in antibacterial preparations belonging to Ayurvedic system of medicine. A bioguided extraction and fractionation of the petroleum ether extract of the berries of P...
  20. ncbi Efficacy of piperine, an alkaloidal constituent from Piper nigrum on erythrocyte antioxidant status in high fat diet and antithyroid drug induced hyperlipidemic rats
    Ramasamy Subramaniam Vijayakumar
    Department of Biochemistry, Annamalai University, Annamalainagar 608 002, Tamilnadu, India
    Cell Biochem Funct 24:491-8. 2006
    ..Thus, our results indicate that piperine supplementation markedly protects erythrocytes from oxidative stress by improving the antioxidant status in HFD fed antithyroid drug treated rats...
  21. ncbi Effect of food seasoning spices mixture on biomarkers of oxidative stress in tissues of fructose-fed insulin-resistant rats
    R Suganthi
    Department of Biochemistry, Faculty of Science, Annamalai University, Annamalai Nagar, Tamil Nadu, India
    J Med Food 10:149-53. 2007
    ..The positive effect of SM on the oxidant-antioxidant balance could be attributed to the active constituents of the different spices present in the mixture...
  22. ncbi Potential use of Piper nigrum ethanol extract against pyrethroid-resistant Aedes aegypti larvae
    Naomi Kato Simas
    Nucleo de Pesquisas de Produtos Naturais, Centro de Ciencias da Saude, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ
    Rev Soc Bras Med Trop 40:405-7. 2007
    Fractionation of Piper nigrum ethanol extract, biomonitored by assays on pyrethroid-resistant Aedes aegypti larvae yielded isolation of the larvicidal amides piperolein-A and piperine. Comparing LC50 values, the ethanol extract (0...
  23. ncbi CYP3A4 inhibitory activity of new bisalkaloids, dipiperamides D and E, and cognates from white pepper
    Sachiko Tsukamoto
    Faculty of Pharmaceutical Sciences, Kanazawa University, 13 1 Takara machi, Kanazawa 920 0934, Japan
    Bioorg Med Chem 10:2981-5. 2002
    ..E, were isolated as inhibitors of a drug metabolizing enzyme cytochrome P450 (CYP) 3A4 from the white pepper, Piper nigrum. Their structures were elucidated by spectroscopic methods...
  24. ncbi Insecticidal amides from fruits of Piper nigrum Linn
    Bina S Siddiqui
    HEJ Research Institute of Chemistry, International Centre for Chemical Sciences, University of Karachi, Karachi 75270, Pakistan
    Nat Prod Res 19:143-50. 2005
    The petroleum ether and ethyl acetate fractions of dried ground seeds of Piper nigrum Linn...
  25. ncbi Piperine lowers the serum concentrations of thyroid hormones, glucose and hepatic 5'D activity in adult male mice
    S Panda
    School of Life Sciences, Devi Ahilya University, Indore, India
    Horm Metab Res 35:523-6. 2003
    Piperine, the main alkaloid of Piper nigrum fruits, was evaluated for its thyroid hormone and glucose regulatory efficacy in adult male Swiss albino mice. Its daily oral administration (2...
  26. ncbi Testosterone 5alpha-reductase inhibitory active constituents of Piper nigrum leaf
    Noriko Hirata
    School of Pharmaceutical Sciences, Kinki University, 3 4 1 Kowakae, Higashiosaka, Osaka 577 8502, Japan
    Biol Pharm Bull 30:2402-5. 2007
    Previously we reported that Piper nigrum leaf extract showed a potent stimulation effect on melanogenesis and that (-)-cubebin (1) and (-)-3,4-dimethoxy-3,4-desmethylenedioxycubebin (2) were isolated as active constituents...
  27. pmc Pungent agents from Szechuan peppers excite sensory neurons by inhibiting two-pore potassium channels
    Diana M Bautista
    Department of Physiology, University of California, San Francisco, 600 16th St, San Francisco, California 94143 2140, USA
    Nat Neurosci 11:772-9. 2008
    ....
  28. ncbi Effect of spices on lipid metabolism in 1,2-dimethylhydrazine-induced rat colon carcinogenesis
    N Nalini
    Department of Biochemistry, Annamalai University, Annamalainagar, Tamilnadu, India
    J Med Food 9:237-45. 2006
    ..We investigated the effect of red chilli (Capsicum annum L.), cumin (Cuminum cyminum L.), and black pepper (Piper nigrum L.) on colon cancer induced in rats by a colon-specific carcinogen, 1,2-dimethylhydrazine (DMH)...
  29. ncbi Antioxidant activity of commonly consumed plant foods of India: contribution of their phenolic content
    Rita Saxena
    Division of Endocrinology and Metabolism, National Institute of Nutrition, Hyderabad, India
    Int J Food Sci Nutr 58:250-60. 2007
    ..86 and r2 =74%, respectively) and dehusked legumes (r=-0.65 and r2 = 42.2%, respectively). The results suggest that phenolics may contribute significantly to the AOA of some plant foods, such as spices and dehusked legumes...
  30. ncbi Chemical compositions and antioxidant properties of essential oils from nine species of Turkish plants obtained by supercritical carbon dioxide extraction and steam distillation
    Ummihan Topal
    Department of Applied Chemistry and Biochemistry, Kumamoto University, Kumamoto, Japan
    Int J Food Sci Nutr 59:619-34. 2008
    ..Rosmarinus officinalis L., Cuminum cyminum L., Piper nigrum L., Lavandula stoechas spp., Foeniculum vulgare, Pimpinella anisum L...
  31. ncbi UV irradiation affects melanocyte stimulatory activity and protein binding of piperine
    Amala Soumyanath
    Department of Pharmacy, King s College London, Franklin Wilkins Building, 150 Stamford Street, London SE1 9NN, UK
    Photochem Photobiol 82:1541-8. 2006
    Piperine, the major alkaloid of black pepper (Piper nigrum L.; Piperaceae), stimulates melanocyte proliferation and dendrite formation in vitro. This property renders it a potential treatment for the skin depigmentation disorder vitiligo...
  32. ncbi Analysis of Piperaceae germplasm by HPLC and LCMS: a method for isolating and identifying unsaturated amides from Piper spp extracts
    Ian M Scott
    Biology Department, University of Ottawa, Ottawa, Ontario, K1N 6N5, Canada
    J Agric Food Chem 53:1907-13. 2005
    ..This allows for a rapid and accurate measure of unsaturated amides, or piperamides, in black pepper, Piper nigrum L., and in wild species from Central America...
  33. ncbi [Control in vitro tick (Boophilus microplus; Acari: Ixodidae) through plant extracts]
    Victor Alvarez
    Ministerio de Agricultura y Ganaderia, Servicio Nacional de Salud Animal, San Jose, Costa Rica
    Rev Biol Trop 56:291-302. 2008
    ..The species that produced the highest mortality were Zizigium aromaticum, Morus alba, Piper nigrum and the mixture of Allium sativum- Z. aromaticum (all non-polar); on oviposition: M. alba, P...
  34. ncbi Stability-indicating reversed-phase liquid chromatographic methods for the determination of aconitine and piperine in a polyherbal formulation
    Pallavi Rai
    The Maharaja Sayajirao University of Baroda, Pharmacy Department, Quality Assurance Laboratory, Centre of Relevance and Excellence in Novel Drug Delivery Systems, G H Patel building, Donor s Plaza, Fatehgunj, Vadodara, Gujarat, India
    J AOAC Int 92:1044-54. 2009
    ..of aconitine (ACN) and piperine (PIN) in Mahamrutynjaya rasa, an herbal dosage form containing Aconitum ferox, Piper nigrum, and Piper longum in combination...
  35. ncbi Effects of piperine on gastric acid secretion in albino rats
    I M Ononiwu
    Department of Pharmacology, College of Health Sciences, University of Port Harcourt, Rivers State, Nigeria
    Afr J Med Med Sci 31:293-5. 2002
    Piperine, the pungent principle in Piper nigrum and Piper guinensis was studied for its effect on gastric acid secretion in white albino rats...
  36. ncbi Cytoprotective and immunomodulating properties of piperine on murine splenocytes: an in vitro study
    Neelima Pathak
    Industrial Toxicology Research Centre, Mahatma Gandhi Marg, P Box 80, Lucknow 226001, India
    Eur J Pharmacol 576:160-70. 2007
    Piper longum Linn. and Piper nigrum Linn. are conventionally used as immuno-enhancers in Indian system of traditional medicine. The underlying mechanism remains unknown...
  37. ncbi Screening for acetylcholinesterase inhibitory activity in plants used in Thai traditional rejuvenating and neurotonic remedies
    Kornkanok Ingkaninan
    Department of Pharmaceutical Chemistry and Pharmacognosy, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok 65000, Thailand
    J Ethnopharmacol 89:261-4. 2003
    ..At the same concentration, four extracts, i.e. stems of Piper interruptum Opiz., seeds of Piper nigrum L., rootbarks of Butea superba Roxb. and roots of Cassia fistula L...
  38. ncbi Comparative study of Rhodiola preparations on behavioral despair of rats
    A Panossian
    Swedish Herbal Institute Research and Development, Spårvägen 2, SE 432 96 Askloster, Sweden
    Phytomedicine 15:84-91. 2008
    ..RPE cannot provide predictable therapeutic effect due to herb-herb interaction. Moreover, concomitant treatment of RPE with other drugs should also be excluded due to drug-piperine interaction...
  39. ncbi Cloning, DNA sequence, and expression of Aeromonas caviae WS7b chitinase gene
    Amarila Malik
    South East Asian Regional Center for Tropical Biology SEAMEO BIOTROP, Jl Raya Tajur Km 6, Bogor, Indonesia
    Mol Biotechnol 23:1-10. 2003
    ..The ability of the chitinase cloned in E. coli to hydrolyze chitin was less than that of the enzyme in its indigenous host...
  40. ncbi Adsorption and removal kinetics of phosphonate from water using natural adsorbents
    R Anil Kumar
    Department of Science and Humanities, National Institute of Technology Calicut, Kozhikode, Kerala, India
    Water Environ Res 82:62-8. 2010
    ..phosphonate is a fungicide used for the control of Phytophthora capsici, which is prevalent in black pepper (Piper nigrum L.). Batch adsorption kinetic experiments were conducted on the adsorption of phosphonate onto the adsorbents...
  41. ncbi Phytochemical studies on the seed extract of Piper nigrum Linn
    Munawwer Rasheed
    H E J Research Institute of Chemistry, International Centre for Chemical Sciences, University of Karachi, Karachi 75270, Pakistan
    Nat Prod Res 19:703-12. 2005
    The petroleum ether extract of dried ground seeds of Piper nigrum Linn...
  42. ncbi Protection of stored maize against Sitophilus zeamais (Motsch.) by use of essential oils of spices from Cameroon
    L S Ngamo
    Faculty of Sciences, Department of Biological Sciences, , P.O. Box 454, , Cameroon
    Meded Rijksuniv Gent Fak Landbouwkd Toegep Biol Wet 66:473-8. 2001
    ..Lamiaceae) 74% after 4 days after ingestion. Piper nigrum (L.) (Piperaceae) killing more than 96% of weevil 48 hours after the contact...
  43. ncbi Piperine, the potential functional food for mood and cognitive disorders
    Jintanaporn Wattanathorn
    Department of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
    Food Chem Toxicol 46:3106-10. 2008
    The effect of piperine, the main alkaloid from piper nigrum, on the central nervous system is not clearly known until now...
  44. ncbi Molecular target of piperine in the inhibition of lipid droplet accumulation in macrophages
    Daisuke Matsuda
    Graduate School of Pharmacy, Kitasato University, Shirokane, Tokyo, Japan
    Biol Pharm Bull 31:1063-6. 2008
    An alkaloid piperine isolated from the Piper Nigrum was found to inhibit lipid droplet accumulation in mouse macrophages, and especially inhibited cholesteryl ester (CE) synthesis (IC50: 25 microM)...
  45. pmc Studies on effect of piperine on oral bioavailability of ampicillin and norfloxacin
    Kunchithapatham Janakiraman
    Kunchithapatham Janakiraman, Selection Grade Lecturer, Department of Pharmacy, Annamalai University, Annamalainagar, Tamil Nadu, India
    Afr J Tradit Complement Altern Med 5:257-62. 2008
    ..These two drugs have low oral bioavailability. Co-administration of Piperine (20mg/kg), an alkaloid from Piper nigrum L. enhanced oral bioavailability of Ampicillin and Norfloxacin in animal model...
  46. ncbi [Potential allelopathic effects of Piper nigrum, Mangifera indica and Clausena lansium]
    Guijun Yan
    College of Environment and Plant Protection, South China University of Tropical Agriculture, Danzhou, China
    Ying Yong Sheng Tai Xue Bao 17:1633-6. 2006
    With Piper nigrum, Mangifera indica and Clausena lansium as the donators, this paper studied their potential allelopathic effects on the germination and growth of Zea mays, Glycine max, Cucurbita moschata, Arachis hypogaea, Raphanus ..
  47. ncbi Herb-drug interactions: a literature review
    Zeping Hu
    Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore
    Drugs 65:1239-82. 2005
    ..Piperine from black (Piper nigrum Linn) and long (P...
  48. ncbi Effects of fragrance inhalation on sympathetic activity in normal adults
    Shinichiro Haze
    Product Development Center, Shiseido Co, Ltd, Hayabuchi, Yokohama, Japan
    Jpn J Pharmacol 90:247-53. 2002
    ..06), while fragrance inhalation of rose oil caused a 30% decrease in adrenaline concentration (P<0.01). Our results indicate that fragrance inhalation of essential oils may modulate sympathetic activity in normal adults...
  49. ncbi Piperine modulates permeability characteristics of intestine by inducing alterations in membrane dynamics: influence on brush border membrane fluidity, ultrastructure and enzyme kinetics
    A Khajuria
    Manitoba Institute of Cell Biology, Winnipeg, Canada
    Phytomedicine 9:224-31. 2002
    Piperine (1-Piperoyl piperidine) is a major alkaloid of Piper nigrum Linn. and Piper longum Linn. It is shown to possess bioavailability-enhancing activity with various structurally and therapeutically diverse drugs...
  50. ncbi In vivo effect of piperine on serum and tissue glycoprotein levels in benzo(a)pyrene induced lung carcinogenesis in Swiss albino mice
    K Selvendiran
    Department of Medical Biochemistry, Dr ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai, India
    Pulm Pharmacol Ther 19:107-11. 2006
    ..Piperine is a pure, pungent alkaloid constituent of black and long peppers (Piper nigrum and Piper longum), that acts as an antioxidant and anticancer agent by its numerous macromolecules associated ..
  51. ncbi A new natural product and insecticidal amides from seeds of Piper nigrum Linn
    Bina S Siddiqui
    International Centre for Chemical Sciences, HEJ Research Institute of Chemistry, University of Karachi, Karachi, Pakistan
    Nat Prod Res 22:1107-11. 2008
    Studies on the petroleum ether soluble and insoluble fraction of ethanol extract of dried ground seeds of Piper nigrum resulted in the isolation and structure elucidation of 1 new and 11 known compounds which include 3 hitherto unreported ..
  52. ncbi Efficacy and safety of topical Trikatu preparation in, relieving mosquito bite reactions: a randomized controlled trial
    Ratree Maenthaisong
    Clinical Pharmacy Research Unit, Department of Clinical Pharmacy, Faculty of Pharmacy, Mahasarakham University, Mahasarakham, Thailand
    Complement Ther Med 22:34-9. 2014
    Trikatu is composed of dried fruits of Piper nigrum L and Piper retrofractum Vahl, and dried rhizomes of Zingiber officinale R...
  53. pmc Piper nigrum leaf and stem assisted green synthesis of silver nanoparticles and evaluation of its antibacterial activity against agricultural plant pathogens
    Kanniah Paulkumar
    Environmental Nanotechnology Division, Sri Paramakalyani Centre for Environmental Sciences, Manonmaniam Sundaranar University, Alwarkurichi, Tamil Nadu 627412, India
    ScientificWorldJournal 2014:829894. 2014
    ..In the present investigation, the silver nanoparticles were synthesized by using the leaf and stem extract of Piper nigrum. The synthesized nanoparticle was characterized by UV-vis spectroscopy, X-ray diffraction (XRD), scanning ..
  54. ncbi Piperine reverses high fat diet-induced hepatic steatosis and insulin resistance in mice
    Seoyoon Choi
    Department of Food and Nutrition, Yonsei University, 50 Yonsei ro, Seodaemun gu, Seoul 120 749, Republic of Korea
    Food Chem 141:3627-35. 2013
    ..Administration of piperine appeared to reverse preexisting HFD-induced hepatic steatosis and insulin resistance, probably by activation of adiponectin-AMPK signalling in mice...
  55. ncbi Fumigant toxicity of essential oils from some common spices against pulse beetle, Callosobruchus chinensis (Coleoptera: Bruchidae)
    Mukesh Kumar Chaubey
    Department of Zoology, Deen Dayal Upadhyay Gorakhpur University, UP, India
    J Oleo Sci 57:171-9. 2008
    ..seven common spices, Anethum graveolens, Cuminum cyminum, Illicium verum, Myristica fragrans, Nigella sativa, Piper nigrum and Trachyspermum ammi was isolated and its insecticidal, oviposition, egg hatching and developmental ..
  56. ncbi Isolation and amplification of genomic DNA from recalcitrant dried berries of black pepper (Piper nigrum L.)--a medicinal spice
    K Dhanya
    Division of Crop Improvement and Biotechnology, Indian Institute of Spices Research, Calicut, Kerala, 673012, India
    Mol Biotechnol 37:165-8. 2007
    ..The protocol has trade implication as it will help in the PCR characterization of traded black peppers from different countries...
  57. ncbi Piperine inhibits IL-β induced expression of inflammatory mediators in human osteoarthritis chondrocyte
    Xiaozhou Ying
    Department of Orthopaedic Surgery, the Second Affiliated Hospital of Wenzhou Medical College, Wenzhou, China
    Int Immunopharmacol 17:293-9. 2013
    Black pepper (Piper nigrum) is a common remedy in Traditional Chinese Medicine and possesses diverse biological activities including anti-inflammatory properties...
  58. pmc Medico - botanical study of Yercaud hills in the eastern Ghats of Tamil Nadu, India
    M Parthipan
    Department of Botany, School of Life Sciences, Bharathiar University, Coimbatore 641046, India
    Anc Sci Life 30:104-9. 2011
    ..R. Br., Justisia adhatoda L., Ocimum sanctum L., Phyllanthes amarus Schum. & Thonn., Piper nigrum L., Solanum nigrum L., Tinospora cordifolia (Thunb.) Miers, Tridax procumbens L...
  59. ncbi Piperine, the main alkaloid of Thai black pepper, protects against neurodegeneration and cognitive impairment in animal model of cognitive deficit like condition of Alzheimer's disease
    Pennapa Chonpathompikunlert
    Department of Physiology and Graduate School, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
    Food Chem Toxicol 48:798-802. 2010
    ..Based on this information, the effect of piperine, a main active alkaloid in fruit of Piper nigrum, on memory performance and neurodegeneration in animal model of Alzheimer's disease have been investigated...
  60. ncbi Effect of piperine on the inhibition of nitric oxide (NO) and TNF-alpha production
    C R Pradeep
    Amala Cancer Research Centre, Thrissur, Kerala, India
    Immunopharmacol Immunotoxicol 25:337-46. 2003
    Effect of piperine which is an alkaloid present in plants such as Piper nigrum and Piper longum on the production of nitric oxide (NO) and tumor necrosis factor-alpha (TNF-alpha) level was analyzed using in vitro as well as in vivo ..
  61. ncbi Potential mechanisms of hypocholesterolaemic effect of Thai spices/dietary extracts
    Acharaporn Duangjai
    Department of Pharmacy Practice and Center of Excellence for Innovation in Chemistry, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok 65000, Thailand
    Nat Prod Res 25:341-52. 2011
    ..Merr., Zingiber officinale, Morus alba L., Camellia sinensis (L.) Kuntze, Piper nigrum L., Alpinia galanga (L.) Willd., Curcuma zedoaria Rose, Bacopa monnieri (L.) Wettst...
  62. ncbi Protective effects of piperine against copper-ascorbate induced toxic injury to goat cardiac mitochondria in vitro
    Mousumi Dutta
    Department of Physiology, Oxidative Stress and Free Radical Biology Laboratory, University of Calcutta, University College of Science and Technology, 92, APC Road, Kolkata 700 009, India
    Food Funct 5:2252-67. 2014
    Piperine, the main alkaloid of black pepper, Piper nigrum Linn., is an important Indian spice used in traditional food and medicine in India...
  63. ncbi Studies on the effects of phosphine on Salmonella enterica serotype Enteritidis in culture medium and in black pepper (Piper nigrum)
    M F P M Castro
    Grupo Especial de Engenharia e Pós Colheita, Instituto de Tecnologia de Alimentos ITAL, Avenida Brasil 2880, Jardim Brasil, Campinas, Sao Paulo, CEP 13070 178, CP 139, Brazil
    J Food Prot 74:665-71. 2011
    ..phosphine on Salmonella enterica serotype Enteritidis inoculated in culture medium and in black pepper grains (Piper nigrum), as well as on the reduction of the microbial load of the dried and moisturized product, was verified...
  64. ncbi Safety assessment of Zanthoxylum alatum Roxb. essential oil, its antifungal, antiaflatoxin, antioxidant activity and efficacy as antimicrobial in preservation of Piper nigrum L. fruits
    Bhanu Prakash
    Laboratory of Herbal Pesticides, Centre of Advanced Study in Botany, Banaras Hindu University, Varanasi 221005, India
    Int J Food Microbiol 153:183-91. 2012
    ..27% and 86.33% protection respectively at 1.25 μl/ml and 2.5 μl/ml against fungi infesting Piper nigrum L. fruits demonstrating its practical efficacy as a plant based antimicrobial for post harvest application.
  65. ncbi Inhibition of monoamine oxidase by derivatives of piperine, an alkaloid from the pepper plant Piper nigrum, for possible use in Parkinson's disease
    Osamah B Al-Baghdadi
    Neurotherapeutics Emphasis Group, Department of Pharmaceutical Sciences, Northeast Ohio Medical University, College of Pharmacy, Rootstown, OH 44272, USA
    Bioorg Med Chem Lett 22:7183-8. 2012
    ..Piperine is an alkaloid from the source plant of both black and white pepper grains, Piper nigrum. Piperine has been shown to have a wide range of activity, including MAO inhibitory activity...
  66. ncbi Synergistic larvicidal effect and morphological alterations induced by ethanolic extracts of Annona muricata and Piper nigrum against the dengue fever vector Aedes aegypti
    Adelia Grzybowski
    Department of Pharmacy Coordination for Graduation on Pharmaceutical Sciences, Federal University of Paraná UFPR, Curitiba, PR, Brazil
    Pest Manag Sci 69:589-601. 2013
    Phytopesticide combinations of different botanical sources are seldom reported. Annona muricata seed and Piper nigrum fruit ethanolic extracts enriched in acetogenins and piperamides, respectively, were synergistically used as larvicides ..
  67. ncbi Antioxidant activity of Piper nigrum L. essential oil extracted by supercritical CO₂ extraction and hydro-distillation
    Hossein Bagheri
    Department of Food Technology, Faculty of Food Science and Technology, Universiti Putra Malaysia, UPM, Serdang, 43400 Selangor, Malaysia Electronic address
    Talanta 121:220-8. 2014
    The aim of this study was to optimize the antioxidant activity of Piper nigrum L. essential oil extracted using the supercritical carbon dioxide (SC-CO₂) technique...
  68. ncbi Oral supplementation of piperine leads to altered phase II enzymes and reduced DNA damage and DNA-protein cross links in Benzo(a)pyrene induced experimental lung carcinogenesis
    Karuppaiyah Selvendiran
    Department of Medical Biochemistry, Dr ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai, India
    Mol Cell Biochem 268:141-7. 2005
    ..Piperine is a pure, pungent alkaloid constituent of black and long peppers (piper nigrum and piper longum), which is a most common spice used throughout the world...
  69. ncbi Binding of bioactive phytochemical piperine with human serum albumin: a spectrofluorometric study
    Dodda Venkatanna Suresh
    Department of Biochemistry and Nutrition, Central Food Technological Research Institute, Mysore 570 020, Karnataka, India
    Biopolymers 86:265-75. 2007
    Piperine, the bioactive alkaloid compound of the spice black pepper (Piper nigrum) exhibits a wide range of beneficial physiological and pharmacological activities...
  70. ncbi Biochemical properties of polysaccharides from black pepper
    Hyug Chun
    Graduate School of Biotechnology, Korea University, Sungbuk Ku, Seoul
    Biol Pharm Bull 25:1203-8. 2002
    The purified polysaccharides from Piper nigrum were prepared as follows: a hot water extract of pepper seeds was fractionated by ultrafiltration with a 5-kDa-membrane cartridge...
  71. ncbi Botanical insecticides for controlling agricultural pests: piperamides and the Colorado Potato Beetle Leptinotarsa decemlineata say (Coleoptera: Chrysomelidae)
    I M Scott
    Biology Department, University of Ottawa, Ottawa, Ontario, Canada
    Arch Insect Biochem Physiol 54:212-25. 2003
    The efficacy of extracts from two Piperaceae species, Piper nigrum L. and P. tuberculatum Jacq. were evaluated using larvae and adults of the Colorado Potato Beetle Leptinotarsa decemlineata (Say)...
  72. ncbi Evidence that the nonstructural protein of Tomato spotted wilt virus is the avirulence determinant in the interaction with resistant pepper carrying the TSW gene
    P Margaria
    Istituto di Virologia Vegetale, Sez di Torino, CNR, Strada delle Cacce 73, Torino 10135, Italy
    Mol Plant Microbe Interact 20:547-58. 2007
    ..Analysis of another RB strain phenotype allowed us to conclude that local necrotic response is not sufficient for resistance in Capsicum spp. carrying the Tsw gene...
  73. ncbi Cobalt(II)-catalyzed intermolecular Diels-Alder reaction of piperine
    Kun Wei
    Faculty of Pharmaceutical Sciences, Toho University, Funabashi, Chiba
    Org Lett 7:2833-5. 2005
    ..For elucidation of the distinction, different cobalt-catalyzed mechanisms were proposed for the Diels-Alder dimerization of piperine...
  74. ncbi Effect of co-administration of piperine on pharmacokinetics of beta-lactam antibiotics in rats
    A R Hiwale
    Research and Development Division of Hindustan Antibiotics Limited, Pimperi, Pune 411 018, India
    Indian J Exp Biol 40:277-81. 2002
    Co-administration of piperine, an alkaloid isolated from Piper nigrum L. enhanced bioavailability of beta lactam antibiotics, amoxycillin trihydrate and cefotaxime sodium significantly in rats...
  75. pmc GABAA receptor modulation by piperine and a non-TRPV1 activating derivative
    Sophia Khom
    Department of Pharmacology and Toxicology, University of Vienna, Althanstraße 14, A 1090 Wien, Austria
    Biochem Pharmacol 85:1827-36. 2013
    ....
  76. ncbi Microwave-assisted synthesis of N-isobutyl-4,5-epoxy-2(E)-decenamide
    Neeraj Gupta
    Department of Chemistry and Centre of Advanced Studies in Chemistry, Panjab University, Chandigarh 160014, India
    Nat Prod Res 27:548-53. 2013
    ..of a naturally occurring amide alkaloid, N-isobutyl-4,5-epoxy-2(E)-decenamide isolated from the roots of Piper nigrum has been described involving a total of nine steps...
  77. ncbi Antioxidant activity of a salt-spice-herbal mixture against free radical induction
    Kavithalakshmi S Natarajan
    ALMPG Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai 600113, India
    J Ethnopharmacol 105:76-83. 2006
    A combination of spices (Piper nigrum, Piper longum and Zingiber officinale), herbs (Cyperus rotundus and Plumbago zeylanica) and salts make up Amrita Bindu...
  78. pmc Chemical composition and fatty acid content of some spices and herbs under Saudi Arabia conditions
    Fahad Mohammed Al-Jasass
    General Directorate of Research Grants, King Abdulaziz City for Science and Technology, P O Box 6086, Riyadh 11442, Saudi Arabia
    ScientificWorldJournal 2012:859892. 2012
    ..The differences in the results obtained are due to environmental factors, production areas, cultivars used to produce seeds and also due to the different methods used to prepare these local spices...
  79. ncbi Element analysis and biological studies on ten oriental spices using XRF and Ames test
    Barakat A Al-Bataina
    Physics Department, Yarmouk University, Irbid, Jordan
    J Trace Elem Med Biol 17:85-90. 2003
    ..tinctorius), caraway (Carum carvi), Sicilian sumac (Rhus coriaria), aniseed (Anisum vulgare), black pepper (Piper nigrum), cardamom (Elettaria cardamomum), cumin (Cuminum cyminum) and nigella (Nigella sativum)...
  80. pmc In vitro antibacterial and antibiotic-potentiation activities of four edible plants against multidrug-resistant gram-negative species
    Jaures A K Noumedem
    Department of Biochemistry, Faculty of Science, University of Dschang, Dschang, Cameroon
    BMC Complement Altern Med 13:190. 2013
    ....
  81. ncbi Microsatellite based analysis of genetic diversity of popular black pepper genotypes in South India
    Nisha Joy
    Plant Molecular Biology Lab, Rajiv Gandhi Centre for Biotechnology, Poojappura, Thiruvananthapuram 695014, India
    Genetica 139:1033-43. 2011
    ..The study was first to portray the precise genetic relatedness among the major indigenous genotypes of black pepper...
  82. ncbi Effect of some medicinal plant extracts on the oxidative stress status in Alzheimer's disease induced in rats
    K Mahdy
    Department of Medical Biochemistry, National Research Center, Cairo University, Cairo, Egypt
    Eur Rev Med Pharmacol Sci 16:31-42. 2012
    ..The present study aims to investigate the effect of Salvia triloba and Piper nigrum plant extracts on the oxidative stress status in Alzheimer's disease induced in rats.
  83. ncbi Protein tyrosine phosphatase 1B inhibitory activity of Indonesian herbal medicines and constituents of Cinnamomum burmannii and Zingiber aromaticum
    Azis Saifudin
    Institute of Natural Medicine, University of Toyama, Toyama, Japan
    J Nat Med 67:264-70. 2013
    ..leaf, Blumea balsamifera, Cinnamomum burmannii, Cymbopogon nardus, Melaleuca leucadendra, Phyllanthus niruri, Piper nigrum, Syzygium aromaticum, and Sy...
  84. ncbi Piperine inhibits PMA-induced cyclooxygenase-2 expression through downregulating NF-κB, C/EBP and AP-1 signaling pathways in murine macrophages
    Hyung Gyun Kim
    Department of Toxicology, College of Pharmacy, Chungnam National University, Daejeon, Republic of Korea
    Food Chem Toxicol 50:2342-8. 2012
    Piperine is a major component of black (Piper nigrum Linn) and long (Piper longum Linn) peppers, and is widely used as a traditional food and medicine...
  85. ncbi Influence of extraction solvents on antioxidant activity and the content of bioactive compounds in non-pungent peppers
    Haejin Bae
    Vegetable and Fruit Improvement Center, Department of Horticultural Sciences, Texas A and M University, College Station, TX, USA
    Plant Foods Hum Nutr 67:120-8. 2012
    ....
  86. ncbi Identification of an miRNA candidate reflects the possible significance of transcribed microsatellites in the hairpin precursors of black pepper
    Nisha Joy
    Plant Molecular Biology, Rajiv Gandhi Centre for Biotechnology, Thycaud P O, Poojappura, Thiruvananthapuram, 695 014 Kerala, India
    Funct Integr Genomics 12:387-95. 2012
    ..genes, we carried out a preliminary analysis to verify the presence of SSRs in the pri-miRNAs of black pepper (Piper nigrum L.). We isolated a (CT) dinucleotide SSR bearing transcript using SMART strategy...
  87. ncbi Pharmacokinetic herb-drug interactions (part 2): drug interactions involving popular botanical dietary supplements and their clinical relevance
    Bill J Gurley
    Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, College of Pharmacy, Little Rock, AR 72205, USA
    Planta Med 78:1490-514. 2012
    ..g., Hydrastis canadensis, Piper nigrum, Schisandra chinensis) or function as ligands for orphan nuclear receptors (e.g., Hypericum perforatum)...
  88. ncbi Structural and sensory characterization of key pungent and tingling compounds from black pepper (Piper nigrum L.)
    Corinna Dawid
    Chair for Food Chemistry and Molecular Sensory Science, Technische Universitat Munchen, Lise Meitner Strasse 34, D 85354 Freising, Germany
    J Agric Food Chem 60:2884-95. 2012
    ..pungent and tingling oral impression imparted by black pepper, an ethanol extract prepared from black pepper (Piper nigrum L.) was screened for its key sensory-active nonvolatiles by application of taste dilution analysis (TDA)...
  89. pmc High-throughput sequencing of black pepper root transcriptome
    Sheila M C Gordo
    Genetics and Molecular Biology Laboratory, COASTAL STUDIES INSTITUTE, Bragança Campus, Universidade Federal do Para, PA, Brazil
    BMC Plant Biol 12:168. 2012
    Black pepper (Piper nigrum L.) is one of the most popular spices in the world. It is used in cooking and the preservation of food and even has medicinal properties...
  90. pmc In vivo effect of some home spices extracts on the toxoplasma gondii tachyzoites
    Najia A Al-Zanbagi
    Biology Department, Science College, King Abdulaziz University, Jeddah, Saudi Arabia
    J Family Community Med 16:59-65. 2009
    ..The anti-toxoplasmic activity of water and ethanol extracts as well as the oil of some home spices (Piper nigrum, Capsicum frutescens, Cinnamomum cassia and Curcuma longa), were evaluated in murine models of intraperitoneal ..
  91. ncbi Antioxidant and anti-atherogenic activities of three Piper species on atherogenic diet fed hamsters
    Gabriel A Agbor
    Institute of Medical Research and Medicinal Plants Studies, PO Box 6163, Yaounde, Cameroon
    Exp Toxicol Pathol 64:387-91. 2012
    ..aims at evaluating the antioxidant and anti-atherosclerotic activities of three Piper species (Piper guineense, Piper nigrum and Piper umbellatum) on atherogenic diet fed hamsters...
  92. ncbi Analysis of the blackening of green pepper (Piper nigrum Linnaeus) berries
    Fenglin Gu
    Spice and Beverage Research Institute, CATAS, Wanning, Hainan 571533, China
    Food Chem 138:797-801. 2013
    ..activity, reduced weight percentage after sun drying, and the changes in colour and appearance of green pepper (Piper nigrum Linnaeus) berries after blanching and sun drying...
  93. ncbi Evaluation of the effect of piperine per se on blood glucose level in alloxan-induced diabetic mice
    Shubham Atal
    Department of Pharmacology, M G M Medical College, Indore, M P 452001, India corrected
    Acta Pol Pharm 69:965-9. 2012
    ..Piperine, the chief alkaloid present in Piper nigrum (black pepper), has a wide array of uses in alternative and complementary therapies...
  94. ncbi Inhibition of lipopolysaccharide-induced inflammatory responses by piperine
    Gi Sang Bae
    Department of Herbology, School of Oriental Medicine, Wonkwang University, Iksan, 540 749 Jeonbuk, South Korea
    Eur J Pharmacol 642:154-62. 2010
    Piperine, a main component of Piper longum Linn. and Piper nigrum Linn., is a plant alkaloid with a long history of medical use. Piperine exhibits anti-inflammatory activity; however, the underlying mechanism remains unknown...
  95. ncbi Characterisation of Phytophthora capsici isolates from black pepper in Vietnam
    Nguyen V Truong
    School of Agriculture and Forestry, Hue University, 102 Phung Hung Street, Hue City, Viet Nam
    Fungal Biol 114:160-70. 2010
    Phytophthora foot rot of black pepper caused by Phytophthora capsici is a major disease of black pepper (Piper nigrum) throughout Vietnam. To understand the population structure of P. capsici, a large collection of P...
  96. ncbi Neuroprotective effect of piperine on primarily cultured hippocampal neurons
    Min Fu
    Medical College, Tsinghua University, China
    Biol Pharm Bull 33:598-603. 2010
    ..These data suggest that the neuroprotective effects of PIP might be associated with suppression of synchronization of neuronal networks, presynaptic glutamic acid release, and Ca(2+) overloading...
  97. ncbi Effect of storage on the essential oil composition of Piper nigrum L. fruits of different ripening states
    Anne Orav
    Institute of Chemistry, Faculty of Science, Tallinn Technical University, Ehitajate tee 5, Tallinn 19086, Estonia
    J Agric Food Chem 52:2582-6. 2004
    ..Differently from other pepper samples, 1 year storage of green pepper corn raised the oil amount more than twice of both drying methods...
  98. ncbi Effect of enzyme activity and frozen storage on jalapeño pepper volatiles by selected ion flow tube-mass spectrometry
    Carolina Azcarate
    Dept of Food Science and Technology, The Ohio State Univ, 2015 Fyffe Rd, Columbus, Ohio 43210, USA
    J Food Sci 75:C710-21. 2010
    ..The compounds (E,Z)-2,6-nonadienal, n-propyl aldehyde, 2-isobutyl-3-methoxypyrazine, and a mixture of terpenes decreased in unblanched and blanched frozen samples, while nonanal and methylbutanal increased only in unblanched samples...
  99. ncbi Mediation of cholino-piperine like receptors by extracts of Piper nigrum induces melanin dispersion in Rana tigerina tadpole melanophores
    Mohammed Sajid
    Postgraduate Department of Biotechnology, Saifia College of Science, Bhopal, India
    J Recept Signal Transduct Res 31:286-90. 2011
    The present study was carried out to determine the effects of lyophilized dried fruit extracts of Piper nigrum and pure piperine on the tadpole melanophores of frog Rana tigerina which offer excellent in vitro opportunities for studying ..
  100. ncbi Tissue distribution & elimination of capsaicin, piperine & curcumin following oral intake in rats
    D Suresh
    Department of Biochemistry and Nutrition, Central Food Technological Research Institute CSIR, Mysore, India
    Indian J Med Res 131:682-91. 2010
    ..bioactive compounds present in spices--turmeric (Curcuma longa), red pepper (Capsicum annuum) and black pepper (Piper nigrum) respectively, have a considerable portion of structural homology...
  101. doi Immunomodulatory role of piperine in cadmium induced thymic atrophy and splenomegaly in mice
    Neelima Pathak
    Indian Institute of Toxicology Research, Mahatma Gandhi Marg, P Box 80, Lucknow 226001, Uttar Pradesh, India
    Environ Toxicol Pharmacol 28:52-60. 2009
    ..Piperine, major alkaloid of Piper longum Linn. and Piper nigrum Linn. with a long history of medicinal value, has shown anti-apoptotic activity in vitro...

Research Grants1

  1. Clinical Assessment of Herb-Drug Interactions
    Bill Gurley; Fiscal Year: 2005
    ..e. CYPIA2, CYP2D6 and CYP3A4); and (3) whether prolonged herb use can modulate P-gp-mediated drug absorption and elimination. ..